locus-tag	class	description
SAIN_RS00010	COG0592	DNA-directed DNA polymerase activity
SAIN_RS00025	COG0012	GTP binding
SAIN_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
SAIN_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SAIN_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SAIN_RS00055	COG0037	tRNA processing
SAIN_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SAIN_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SAIN_RS00180	COG1792	Involved in formation and maintenance of cell shape
SAIN_RS00190	COG3942	CHAP domain
SAIN_RS00195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SAIN_RS00200	COG0436	Aminotransferase
SAIN_RS00205	COG1381	Involved in DNA repair and RecF pathway recombination
SAIN_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAIN_RS00220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SAIN_RS00235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SAIN_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SAIN_RS00250	COG3942	CHAP domain
SAIN_RS00255	COG0151	Belongs to the GarS family
SAIN_RS00260	COG1683	Conserved Protein
SAIN_RS00265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SAIN_RS00290	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SAIN_RS00295	COG2376	Dihydroxyacetone kinase
SAIN_RS00305	COG2376	Dihydroxyacetone kinase
SAIN_RS00310	COG1461	Dihydroxyacetone kinase
SAIN_RS00315	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SAIN_RS00320	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAIN_RS00340	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAIN_RS00350	COG3716	PTS system mannose fructose sorbose family IID component
SAIN_RS00360	COG2222	sugar isomerase
SAIN_RS00365	COG3684	Belongs to the aldolase LacD family
SAIN_RS00370	COG2017	converts alpha-aldose to the beta-anomer
SAIN_RS00375	COG2255	four-way junction helicase activity
SAIN_RS00385	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SAIN_RS00400	COG1454	alcohol dehydrogenase
SAIN_RS00400	COG1012	belongs to the aldehyde dehydrogenase family
SAIN_RS00405	COG1454	alcohol dehydrogenase
SAIN_RS00410	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SAIN_RS00420	COG1175	transmembrane transport
SAIN_RS00425	COG0395	ABC-type sugar transport system, permease component
SAIN_RS00440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAIN_RS00460	COG1269	ATP hydrolysis coupled proton transport
SAIN_RS00465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAIN_RS00475	COG1527	subunit (C
SAIN_RS00480	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SAIN_RS00490	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SAIN_RS00495	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SAIN_RS00500	COG1394	ATPase activity, coupled to movement of substances
SAIN_RS00515	COG1309	transcriptional regulator
SAIN_RS00520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SAIN_RS00540	COG3759	membrane
SAIN_RS00545	COG1914	H( )-stimulated, divalent metal cation uptake system
SAIN_RS00570	COG1846	Transcriptional regulator
SAIN_RS00575	COG1121	(ABC) transporter
SAIN_RS00580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SAIN_RS00585	COG0803	Belongs to the bacterial solute-binding protein 9 family
SAIN_RS00585	COG3443	Belongs to the bacterial solute-binding protein 9 family
SAIN_RS00595	COG2217	Heavy metal translocating P-type atpase
SAIN_RS00605	COG0564	pseudouridine synthase activity
SAIN_RS00610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAIN_RS00745	COG4115	mRNA cleavage
SAIN_RS00775	COG0789	Transcriptional regulator
SAIN_RS00780	COG2081	HI0933 family
SAIN_RS00790	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SAIN_RS00795	COG0584	glycerophosphoryl diester phosphodiesterase
SAIN_RS00800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SAIN_RS00810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SAIN_RS00825	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SAIN_RS00845	COG1304	FMN binding
SAIN_RS00855	COG3425	synthase
SAIN_RS00870	COG1882	Formate acetyltransferase
SAIN_RS00875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SAIN_RS00890	COG0756	dUTP diphosphatase activity
SAIN_RS00900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SAIN_RS00905	COG2171	N-acyltransferase activity
SAIN_RS00910	COG1473	amidohydrolase
SAIN_RS00915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SAIN_RS00925	COG2226	methyltransferase
SAIN_RS00930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SAIN_RS00940	COG0085	RNA polymerase activity
SAIN_RS00945	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SAIN_RS00950	COG0126	phosphoglycerate kinase activity
SAIN_RS00960	COG0789	Transcriptional regulator
SAIN_RS00965	COG0174	glutamine synthetase
SAIN_RS00975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SAIN_RS00980	COG1459	type II secretion system
SAIN_RS00985	COG4537	Required for transformation and DNA binding
SAIN_RS01015	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SAIN_RS01035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SAIN_RS01040	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
SAIN_RS01050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SAIN_RS01055	COG4589	Belongs to the CDS family
SAIN_RS01060	COG0750	zinc metalloprotease
SAIN_RS01065	COG0442	prolyl-tRNA aminoacylation
SAIN_RS01075	COG0285	dihydrofolate synthase activity
SAIN_RS01085	COG1363	Peptidase, m42
SAIN_RS01095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAIN_RS01100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAIN_RS01115	COG4585	Histidine kinase
SAIN_RS01120	COG2197	response regulator
SAIN_RS01140	COG3715	PTS system
SAIN_RS01145	COG3716	PTS system mannose fructose sorbose family IID component
SAIN_RS01155	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SAIN_RS01160	COG0459	protein refolding
SAIN_RS01175	COG1428	Deoxynucleoside kinase
SAIN_RS01180	COG1418	mRNA catabolic process
SAIN_RS01195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SAIN_RS01215	COG2264	protein methyltransferase activity
SAIN_RS01220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SAIN_RS01230	COG1490	D-aminoacyl-tRNA deacylase activity
SAIN_RS01255	COG3590	peptidase
SAIN_RS01260	COG4988	ABC transporter
SAIN_RS01265	COG1132	(ABC) transporter
SAIN_RS01300	COG0527	aspartate kinase activity
SAIN_RS01305	COG1024	Enoyl-CoA hydratase
SAIN_RS01315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SAIN_RS01325	COG2070	2-Nitropropane dioxygenase
SAIN_RS01330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SAIN_RS01340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SAIN_RS01350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SAIN_RS01355	COG0439	Biotin carboxylase
SAIN_RS01360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SAIN_RS01365	COG0825	malonyl-CoA metabolic process
SAIN_RS01370	COG0586	Pfam SNARE associated Golgi protein
SAIN_RS01375	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SAIN_RS01385	COG3716	PTS system mannose fructose sorbose family IID component
SAIN_RS01390	COG3715	PTS system
SAIN_RS01400	COG0561	phosphatase activity
SAIN_RS01410	COG2252	PERMEase
SAIN_RS01415	COG0802	atpase or kinase
SAIN_RS01425	COG1316	TRANSCRIPTIONal
SAIN_RS01435	COG0537	adenosine 5'-monophosphoramidase activity
SAIN_RS01440	COG1131	(ABC) transporter
SAIN_RS01450	COG0510	thiamine kinase activity
SAIN_RS01455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SAIN_RS01465	COG0779	Required for maturation of 30S ribosomal subunits
SAIN_RS01470	COG0195	Participates in both transcription termination and antitermination
SAIN_RS01475	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SAIN_RS01490	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SAIN_RS01510	COG0656	L-ascorbic acid biosynthetic process
SAIN_RS01530	COG0752	glycyl-tRNA synthetase alpha subunit
SAIN_RS01535	COG0751	glycine-tRNA ligase activity
SAIN_RS01550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SAIN_RS01565	COG0275	rRNA processing
SAIN_RS01575	COG0768	penicillin binding
SAIN_RS01580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAIN_RS01585	COG4166	transmembrane transport
SAIN_RS01595	COG0191	fructose-bisphosphate aldolase activity
SAIN_RS01620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SAIN_RS01630	COG1461	Dihydroxyacetone kinase
SAIN_RS01635	COG1131	(ABC) transporter
SAIN_RS01640	COG0842	Transport permease protein
SAIN_RS01645	COG4585	Histidine kinase
SAIN_RS01650	COG2197	response regulator
SAIN_RS01665	COG1126	abc transporter atp-binding protein
SAIN_RS01670	COG0765	amino acid transport
SAIN_RS01680	COG1968	undecaprenyl-diphosphatase activity
SAIN_RS01690	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SAIN_RS01695	COG4862	establishment of competence for transformation
SAIN_RS01700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SAIN_RS01710	COG0719	Fe-S assembly protein
SAIN_RS01715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SAIN_RS01725	COG1686	Belongs to the peptidase S11 family
SAIN_RS01730	COG0513	Belongs to the DEAD box helicase family
SAIN_RS01740	COG1126	abc transporter atp-binding protein
SAIN_RS01750	COG0492	ferredoxin-NADP+ reductase activity
SAIN_RS01755	COG1113	amino acid transport
SAIN_RS01760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SAIN_RS01765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SAIN_RS01770	COG3579	cysteine-type endopeptidase activity
SAIN_RS01775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SAIN_RS01780	COG3331	DNA recombination
SAIN_RS01785	COG4474	Belongs to the UPF0398 family
SAIN_RS01840	COG0551	DNA topoisomerase type I activity
SAIN_RS01840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAIN_RS01915	COG1598	PFAM Uncharacterised protein family UPF0150
SAIN_RS01935	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAIN_RS01940	COG1192	Involved in chromosome partitioning
SAIN_RS01990	COG3599	regulation of cell shape
SAIN_RS01995	COG0116	Belongs to the methyltransferase superfamily
SAIN_RS02005	COG0450	alkyl hydroperoxide reductase
SAIN_RS02010	COG3634	alkyl hydroperoxide reductase activity
SAIN_RS02020	COG1418	mRNA catabolic process
SAIN_RS02025	COG0194	GDP metabolic process
SAIN_RS02030	COG1758	RNA polymerase activity
SAIN_RS02035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SAIN_RS02040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SAIN_RS02045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SAIN_RS02045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SAIN_RS02050	COG0631	protein serine/threonine phosphatase activity
SAIN_RS02055	COG0515	serine threonine protein kinase
SAIN_RS02055	COG2815	serine threonine protein kinase
SAIN_RS02080	COG1185	polyribonucleotide nucleotidyltransferase activity
SAIN_RS02090	COG3557	Belongs to the UPF0374 family
SAIN_RS02095	COG2137	regulation of response to DNA damage stimulus
SAIN_RS02105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SAIN_RS02115	COG2070	2-Nitropropane dioxygenase
SAIN_RS02135	COG0519	Catalyzes the synthesis of GMP from XMP
SAIN_RS02145	COG0525	valine-tRNA ligase activity
SAIN_RS02160	COG1739	Uncharacterized protein family UPF0029
SAIN_RS02165	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SAIN_RS02170	COG1040	competence protein
SAIN_RS02180	COG0742	ribosomal rna small subunit methyltransferase
SAIN_RS02185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SAIN_RS02190	COG3480	Lon protease (S16) C-terminal proteolytic domain
SAIN_RS02195	COG4470	Protein conserved in bacteria
SAIN_RS02200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SAIN_RS02210	COG0133	tryptophan synthase activity
SAIN_RS02215	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SAIN_RS02235	COG1187	pseudouridine synthase activity
SAIN_RS02240	COG1217	gtp-binding protein TYPA
SAIN_RS02250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SAIN_RS02255	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SAIN_RS02260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SAIN_RS02270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SAIN_RS02275	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SAIN_RS02280	COG1799	cell septum assembly
SAIN_RS02295	COG3599	regulation of cell shape
SAIN_RS02300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SAIN_RS02305	COG1846	Transcriptional regulator
SAIN_RS02315	COG0628	permease
SAIN_RS02325	COG1253	flavin adenine dinucleotide binding
SAIN_RS02330	COG2188	Transcriptional regulator
SAIN_RS02350	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SAIN_RS02375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SAIN_RS02380	COG2244	polysaccharide biosynthetic process
SAIN_RS02385	COG0626	cystathionine gamma-synthase activity
SAIN_RS02390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SAIN_RS02395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAIN_RS02400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SAIN_RS02405	COG0740	serine-type endopeptidase activity
SAIN_RS02440	COG0517	IMP dehydrogenase activity
SAIN_RS02445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SAIN_RS02450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SAIN_RS02455	COG0470	DNA polymerase III
SAIN_RS02460	COG4467	Involved in initiation control of chromosome replication
SAIN_RS02470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SAIN_RS02475	COG1393	Belongs to the ArsC family
SAIN_RS02480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SAIN_RS02485	COG0708	Exodeoxyribonuclease III
SAIN_RS02495	COG0640	Transcriptional regulator
SAIN_RS02520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAIN_RS02520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAIN_RS02530	COG0745	RESPONSE REGULATOR receiver
SAIN_RS02535	COG0642	Histidine kinase
SAIN_RS02545	COG1136	(ABC) transporter
SAIN_RS02550	COG0577	efflux transmembrane transporter activity
SAIN_RS02575	COG1136	(ABC) transporter
SAIN_RS02580	COG0577	efflux transmembrane transporter activity
SAIN_RS02585	COG0531	amino acid
SAIN_RS02590	COG0456	acetyltransferase
SAIN_RS02620	COG1028	Short-chain dehydrogenase reductase Sdr
SAIN_RS02640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SAIN_RS02655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SAIN_RS02665	COG0488	(ABC) transporter
SAIN_RS02680	COG1983	PspC domain protein
SAIN_RS02685	COG1674	ftsk spoiiie
SAIN_RS02685	COG0697	spore germination
SAIN_RS02690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAIN_RS02705	COG0081	regulation of translation
SAIN_RS02710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SAIN_RS02715	COG0372	Belongs to the citrate synthase family
SAIN_RS02720	COG0538	isocitrate dehydrogenase activity
SAIN_RS02725	COG0528	UMP kinase activity
SAIN_RS02730	COG0233	cytoplasmic translational termination
SAIN_RS02735	COG2996	Protein conserved in bacteria
SAIN_RS02745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SAIN_RS02755	COG2274	protein secretion by the type I secretion system
SAIN_RS02760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SAIN_RS02770	COG3290	protein histidine kinase activity
SAIN_RS02785	COG2801	Transposase and inactivated derivatives
SAIN_RS02845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SAIN_RS02850	COG0549	Belongs to the carbamate kinase family
SAIN_RS02855	COG1288	antiporter activity
SAIN_RS02860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAIN_RS02865	COG2801	Transposase and inactivated derivatives
SAIN_RS02875	COG1438	arginine binding
SAIN_RS02880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SAIN_RS02885	COG0363	glucosamine-6-phosphate deaminase activity
SAIN_RS02905	COG2723	6-phospho-beta-galactosidase activity
SAIN_RS02915	COG4095	Psort location CytoplasmicMembrane, score
SAIN_RS02925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAIN_RS02925	COG3711	transcriptional antiterminator
SAIN_RS02930	COG1447	Phosphotransferase system cellobiose-specific component IIA
SAIN_RS02940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAIN_RS02955	COG4122	O-methyltransferase activity
SAIN_RS02960	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SAIN_RS02970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SAIN_RS02980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SAIN_RS02995	COG2348	transferase activity, transferring amino-acyl groups
SAIN_RS03000	COG2348	transferase activity, transferring amino-acyl groups
SAIN_RS03010	COG1078	dGTPase activity
SAIN_RS03040	COG0561	phosphatase activity
SAIN_RS03045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SAIN_RS03050	COG2884	Cell division ATP-binding protein ftsE
SAIN_RS03055	COG2177	Part of the ABC transporter FtsEX involved in
SAIN_RS03065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SAIN_RS03065	COG1199	ATP-dependent helicase activity
SAIN_RS03075	COG0772	Belongs to the SEDS family
SAIN_RS03080	COG0693	protein deglycase activity
SAIN_RS03090	COG0187	DNA topoisomerase II activity
SAIN_RS03095	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SAIN_RS03115	COG2706	6-phosphogluconolactonase activity
SAIN_RS03120	COG0745	RESPONSE REGULATOR receiver
SAIN_RS03125	COG3850	Histidine kinase
SAIN_RS03125	COG5002	protein histidine kinase activity
SAIN_RS03130	COG0628	permease
SAIN_RS03140	COG0028	Belongs to the TPP enzyme family
SAIN_RS03145	COG3527	Alpha-acetolactate decarboxylase
SAIN_RS03150	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SAIN_RS03165	COG3842	ATPase activity
SAIN_RS03175	COG4443	Transcriptional Coactivator p15 (PC4)
SAIN_RS03180	COG4152	abc transporter atp-binding protein
SAIN_RS03185	COG1668	transmembrane transport
SAIN_RS03190	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SAIN_RS03195	COG1074	ATP-dependent DNA helicase activity
SAIN_RS03200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SAIN_RS03205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SAIN_RS03210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SAIN_RS03215	COG0297	glycogen (starch) synthase activity
SAIN_RS03220	COG0058	SHG alpha-glucan phosphorylase activity
SAIN_RS03230	COG0356	it plays a direct role in the translocation of protons across the membrane
SAIN_RS03235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SAIN_RS03240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SAIN_RS03245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SAIN_RS03250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SAIN_RS03270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAIN_RS03290	COG1132	(ABC) transporter
SAIN_RS03310	COG1346	cytolysis
SAIN_RS03315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAIN_RS03320	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SAIN_RS03330	COG2384	SAM-dependent methyltransferase
SAIN_RS03335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SAIN_RS03340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SAIN_RS03355	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SAIN_RS03365	COG1088	dTDP-glucose 4,6-dehydratase activity
SAIN_RS03370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SAIN_RS03380	COG0463	Glycosyl transferase, family 2
SAIN_RS03405	COG0463	Glycosyl transferase, family 2
SAIN_RS03410	COG1091	dTDP-4-dehydrorhamnose reductase activity
SAIN_RS03450	COG0006	proline dipeptidase activity
SAIN_RS03455	COG1609	Transcriptional regulator
SAIN_RS03465	COG0438	transferase activity, transferring glycosyl groups
SAIN_RS03475	COG0745	RESPONSE REGULATOR receiver
SAIN_RS03480	COG5002	protein histidine kinase activity
SAIN_RS03485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SAIN_RS03495	COG0571	ribonuclease III activity
SAIN_RS03500	COG1196	nuclear chromosome segregation
SAIN_RS03505	COG0561	phosphatase activity
SAIN_RS03510	COG0561	phosphatase activity
SAIN_RS03515	COG0552	protein localization to endoplasmic reticulum
SAIN_RS03520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SAIN_RS03525	COG0477	Major facilitator Superfamily
SAIN_RS03530	COG3689	TIGRFAM TIGR03943 family protein
SAIN_RS03535	COG0701	Predicted permease
SAIN_RS03540	COG2183	response to ionizing radiation
SAIN_RS03545	COG3091	SprT-like family
SAIN_RS03560	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SAIN_RS03565	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SAIN_RS03590	COG0826	peptidase U32
SAIN_RS03615	COG0488	(ABC) transporter
SAIN_RS03630	COG3442	glutamine amidotransferase
SAIN_RS03635	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SAIN_RS03640	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SAIN_RS03650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAIN_RS03655	COG0560	Phosphoserine phosphatase
SAIN_RS03680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SAIN_RS03690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SAIN_RS03700	COG0346	lactoylglutathione lyase activity
SAIN_RS03705	COG0726	polysaccharide deacetylase
SAIN_RS03715	COG0673	inositol 2-dehydrogenase activity
SAIN_RS03720	COG0572	uridine kinase
SAIN_RS03730	COG2195	Cleaves the N-terminal amino acid of tripeptides
SAIN_RS03735	COG0561	phosphatase activity
SAIN_RS03740	COG0481	GTPase activity
SAIN_RS03750	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SAIN_RS03755	COG3842	ATPase activity
SAIN_RS03760	COG1176	ABC-type spermidine putrescine transport system, permease component I
SAIN_RS03765	COG1177	transmembrane transport
SAIN_RS03780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAIN_RS03780	COG0574	Belongs to the PEP-utilizing enzyme family
SAIN_RS03785	COG0517	IMP dehydrogenase activity
SAIN_RS03790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SAIN_RS03795	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SAIN_RS03800	COG1104	cysteine desulfurase activity
SAIN_RS03805	COG0301	tRNA thio-modification
SAIN_RS03810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SAIN_RS03820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SAIN_RS03830	COG0425	Belongs to the sulfur carrier protein TusA family
SAIN_RS03830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SAIN_RS03835	COG0446	pyridine nucleotide-disulphide oxidoreductase
SAIN_RS03850	COG1937	Protein conserved in bacteria
SAIN_RS03860	COG0583	DNA-binding transcription factor activity
SAIN_RS03870	COG0564	pseudouridine synthase activity
SAIN_RS03885	COG2824	Alkylphosphonate utilization operon protein PhnA
SAIN_RS03905	COG0038	chloride channel
SAIN_RS03910	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SAIN_RS03915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SAIN_RS03930	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SAIN_RS03935	COG1388	LysM domain
SAIN_RS03935	COG1705	Flagellar rod assembly protein muramidase FlgJ
SAIN_RS03945	COG1132	(ABC) transporter
SAIN_RS03950	COG0488	(ABC) transporter
SAIN_RS03970	COG0556	nucleotide-excision repair
SAIN_RS03980	COG1131	(ABC) transporter
SAIN_RS03990	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SAIN_RS04000	COG0647	UMP catabolic process
SAIN_RS04020	COG1660	Displays ATPase and GTPase activities
SAIN_RS04025	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SAIN_RS04030	COG1481	regulation of sporulation
SAIN_RS04035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SAIN_RS04045	COG0540	Belongs to the ATCase OTCase family
SAIN_RS04050	COG0505	Belongs to the CarA family
SAIN_RS04055	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SAIN_RS04060	COG2814	Major facilitator Superfamily
SAIN_RS04095	COG0543	2 iron, 2 sulfur cluster binding
SAIN_RS04100	COG0167	dihydroorotate dehydrogenase activity
SAIN_RS04155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAIN_RS04155	COG0551	DNA topoisomerase type I activity
SAIN_RS04230	COG1598	PFAM Uncharacterised protein family UPF0150
SAIN_RS04250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAIN_RS04255	COG1192	Involved in chromosome partitioning
SAIN_RS04305	COG0284	orotidine-5'-phosphate decarboxylase activity
SAIN_RS04315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SAIN_RS04330	COG4479	Belongs to the UPF0346 family
SAIN_RS04335	COG1702	phosphate starvation-inducible protein PhoH
SAIN_RS04350	COG0686	Belongs to the AlaDH PNT family
SAIN_RS04375	COG1132	(ABC) transporter
SAIN_RS04380	COG1132	(ABC) transporter
SAIN_RS04385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SAIN_RS04390	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SAIN_RS04395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SAIN_RS04425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SAIN_RS04430	COG0237	dephospho-CoA kinase activity
SAIN_RS04435	COG2814	Major facilitator Superfamily
SAIN_RS04445	COG0557	exoribonuclease II activity
SAIN_RS04455	COG2801	Transposase and inactivated derivatives
SAIN_RS04465	COG1555	photosystem II stabilization
SAIN_RS04470	COG0658	competence protein
SAIN_RS04470	COG2333	competence protein COMEC
SAIN_RS04485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SAIN_RS04490	COG1051	belongs to the nudix hydrolase family
SAIN_RS04495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SAIN_RS04500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SAIN_RS04505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SAIN_RS04515	COG4109	DRTGG domain
SAIN_RS04520	COG0024	Methionine aminopeptidase
SAIN_RS04530	COG1846	Transcriptional regulator
SAIN_RS04540	COG2246	polysaccharide biosynthetic process
SAIN_RS04545	COG4708	membrane
SAIN_RS04550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SAIN_RS04555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SAIN_RS04560	COG1597	lipid kinase activity
SAIN_RS04565	COG1523	belongs to the glycosyl hydrolase 13 family
SAIN_RS04570	COG0228	four-way junction DNA binding
SAIN_RS04575	COG1837	Belongs to the UPF0109 family
SAIN_RS04580	COG1827	regulation of RNA biosynthetic process
SAIN_RS04595	COG3142	Participates in the control of copper homeostasis
SAIN_RS04600	COG2315	Protein conserved in bacteria
SAIN_RS04605	COG1132	(ABC) transporter
SAIN_RS04610	COG1132	(ABC) transporter
SAIN_RS04615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SAIN_RS04625	COG1518	maintenance of DNA repeat elements
SAIN_RS04650	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SAIN_RS04655	COG1970	mechanosensitive ion channel activity
SAIN_RS04660	COG0358	DNA primase activity
SAIN_RS04665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SAIN_RS04670	COG2151	metal-sulfur cluster biosynthetic enzyme
SAIN_RS04675	COG1114	Component of the transport system for branched-chain amino acids
SAIN_RS04680	COG0785	Cytochrome C biogenesis protein
SAIN_RS04685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SAIN_RS04690	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAIN_RS04690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAIN_RS04700	COG2972	Histidine kinase
SAIN_RS04715	COG4555	ABC transporter
SAIN_RS04720	COG1053	succinate dehydrogenase
SAIN_RS04720	COG3976	FMN-binding domain protein
SAIN_RS04720	COG0431	NADPH-dependent FMN reductase
SAIN_RS04740	COG2205	protein histidine kinase activity
SAIN_RS04745	COG0745	RESPONSE REGULATOR receiver
SAIN_RS04775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAIN_RS04780	COG2233	PERMEase
SAIN_RS04785	COG0534	Mate efflux family protein
SAIN_RS04790	COG1942	4-Oxalocrotonate Tautomerase
SAIN_RS04795	COG1435	thymidine kinase activity
SAIN_RS04800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SAIN_RS04805	COG2890	protein-(glutamine-N5) methyltransferase activity
SAIN_RS04815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SAIN_RS04825	COG0741	lytic transglycosylase activity
SAIN_RS04840	COG2188	Transcriptional regulator
SAIN_RS04850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SAIN_RS04860	COG4974	Belongs to the 'phage' integrase family
SAIN_RS04865	COG1028	Short-chain dehydrogenase reductase Sdr
SAIN_RS04870	COG0095	Lipoate-protein ligase
SAIN_RS04875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAIN_RS04880	COG0508	dehydrogenase complex catalyzes the overall conversion of
SAIN_RS04885	COG0022	dehydrogenase e1 component
SAIN_RS04890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SAIN_RS04910	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SAIN_RS04915	COG0135	phosphoribosylanthranilate isomerase activity
SAIN_RS04920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAIN_RS04925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SAIN_RS04930	COG0758	DNA mediated transformation
SAIN_RS04935	COG0110	maltose O-acetyltransferase activity
SAIN_RS04940	COG3711	transcriptional antiterminator
SAIN_RS04950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SAIN_RS04955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SAIN_RS04960	COG1960	acyl-CoA dehydrogenase activity
SAIN_RS04965	COG0583	DNA-binding transcription factor activity
SAIN_RS04970	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SAIN_RS04980	COG1024	Enoyl-CoA hydratase
SAIN_RS04985	COG0183	Belongs to the thiolase family
SAIN_RS04990	COG1250	3-hydroxyacyl-CoA dehydrogenase
SAIN_RS04995	COG1960	acyl-CoA dehydrogenase activity
SAIN_RS05000	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAIN_RS05005	COG3764	Sortase (surface protein transpeptidase)
SAIN_RS05010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAIN_RS05015	COG0039	L-malate dehydrogenase activity
SAIN_RS05030	COG0539	negative regulation of cytoplasmic translation
SAIN_RS05050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SAIN_RS05055	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SAIN_RS05075	COG0187	DNA topoisomerase II activity
SAIN_RS05080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SAIN_RS05085	COG0737	Belongs to the 5'-nucleotidase family
SAIN_RS05090	COG2976	Protein conserved in bacteria
SAIN_RS05095	COG2131	deaminase
SAIN_RS05100	COG1309	transcriptional regulator
SAIN_RS05145	COG2814	Major facilitator Superfamily
SAIN_RS05150	COG0017	Asparaginyl-tRNA synthetase
SAIN_RS05160	COG0436	Aminotransferase
SAIN_RS05170	COG1846	Transcriptional regulator
SAIN_RS05180	COG3022	response to hydroperoxide
SAIN_RS05190	COG1272	protein, Hemolysin III
SAIN_RS05195	COG1079	Belongs to the binding-protein-dependent transport system permease family
SAIN_RS05200	COG4603	Belongs to the binding-protein-dependent transport system permease family
SAIN_RS05205	COG3845	ABC transporter
SAIN_RS05210	COG1744	ABC transporter substrate-binding protein PnrA-like
SAIN_RS05215	COG0295	cytidine deaminase activity
SAIN_RS05220	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SAIN_RS05230	COG2813	Specifically methylates the guanine in position
SAIN_RS05235	COG1072	(Pantothenic acid kinase))
SAIN_RS05240	COG0268	Binds directly to 16S ribosomal RNA
SAIN_RS05250	COG4187	Peptidase family M20/M25/M40
SAIN_RS05260	COG5002	protein histidine kinase activity
SAIN_RS05265	COG0745	RESPONSE REGULATOR receiver
SAIN_RS05320	COG1674	ftsk spoiiie
SAIN_RS05355	COG1940	carbohydrate kinase activity
SAIN_RS05375	COG0656	L-ascorbic acid biosynthetic process
SAIN_RS05395	COG0083	homoserine kinase activity
SAIN_RS05405	COG0726	polysaccharide deacetylase
SAIN_RS05415	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SAIN_RS05420	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SAIN_RS05425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SAIN_RS05430	COG1609	Transcriptional regulator
SAIN_RS05435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SAIN_RS05435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SAIN_RS05450	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SAIN_RS05455	COG1956	GAF domain-containing protein
SAIN_RS05475	COG3443	Belongs to the bacterial solute-binding protein 9 family
SAIN_RS05475	COG0803	Belongs to the bacterial solute-binding protein 9 family
SAIN_RS05480	COG0336	Belongs to the RNA methyltransferase TrmD family
SAIN_RS05485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SAIN_RS05500	COG4974	Belongs to the 'phage' integrase family
SAIN_RS05540	COG0222	ribosome binding
SAIN_RS05545	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SAIN_RS05550	COG3708	Transcriptional regulator
SAIN_RS05550	COG2207	Transcriptional regulator
SAIN_RS05565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SAIN_RS05570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SAIN_RS05585	COG1247	-acetyltransferase
SAIN_RS05590	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SAIN_RS05600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SAIN_RS05605	COG4684	Psort location CytoplasmicMembrane, score
SAIN_RS05610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAIN_RS05625	COG0582	viral genome integration into host DNA
SAIN_RS05640	COG2801	Transposase and inactivated derivatives
SAIN_RS05700	COG0280	phosphate acetyltransferase
SAIN_RS05705	COG0564	pseudouridine synthase activity
SAIN_RS05715	COG2357	RelA SpoT domain protein
SAIN_RS05730	COG1104	cysteine desulfurase activity
SAIN_RS05745	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAIN_RS05750	COG2003	Belongs to the UPF0758 family
SAIN_RS05765	COG2801	Transposase and inactivated derivatives
SAIN_RS05770	COG0704	Plays a role in the regulation of phosphate uptake
SAIN_RS05775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAIN_RS05780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SAIN_RS05785	COG0581	inorganic phosphate transmembrane transporter activity
SAIN_RS05790	COG0573	inorganic phosphate transmembrane transporter activity
SAIN_RS05800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SAIN_RS05800	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SAIN_RS05805	COG0483	inositol monophosphate 1-phosphatase activity
SAIN_RS05810	COG4476	Belongs to the UPF0223 family
SAIN_RS05815	COG1393	Belongs to the ArsC family
SAIN_RS05820	COG0196	riboflavin kinase activity
SAIN_RS05825	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SAIN_RS05835	COG1132	(ABC) transporter
SAIN_RS05840	COG2375	cellular response to nickel ion
SAIN_RS05840	COG1132	(ABC) transporter
SAIN_RS05845	COG2378	regulation of single-species biofilm formation
SAIN_RS05855	COG0210	DNA helicase
SAIN_RS05860	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SAIN_RS05870	COG1126	abc transporter atp-binding protein
SAIN_RS05875	COG0765	amino acid transport
SAIN_RS05885	COG0469	pyruvate kinase activity
SAIN_RS05890	COG0205	6-phosphofructokinase activity
SAIN_RS05900	COG1725	Transcriptional regulator
SAIN_RS05905	COG1131	(ABC) transporter
SAIN_RS05915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SAIN_RS05915	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SAIN_RS05930	COG0300	oxidoreductase activity
SAIN_RS05950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SAIN_RS05955	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SAIN_RS05960	COG0577	efflux transmembrane transporter activity
SAIN_RS05965	COG1136	(ABC) transporter
SAIN_RS05975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SAIN_RS05980	COG1268	BioY protein
SAIN_RS05995	COG1011	Hydrolase
SAIN_RS06015	COG0072	phenylalanine-tRNA ligase activity
SAIN_RS06015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SAIN_RS06030	COG0488	(ABC) transporter
SAIN_RS06035	COG0617	tRNA 3'-terminal CCA addition
SAIN_RS06040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SAIN_RS06045	COG1307	EDD domain protein, DegV family
SAIN_RS06055	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAIN_RS06055	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SAIN_RS06055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SAIN_RS06060	COG1105	Belongs to the carbohydrate kinase PfkB family
SAIN_RS06065	COG1349	DNA-binding transcription factor activity
SAIN_RS06075	COG0492	ferredoxin-NADP+ reductase activity
SAIN_RS06080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SAIN_RS06105	COG2801	Transposase and inactivated derivatives
SAIN_RS06110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SAIN_RS06120	COG0077	Prephenate dehydratase
SAIN_RS06125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SAIN_RS06130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SAIN_RS06140	COG3679	Belongs to the UPF0342 family
SAIN_RS06145	COG0287	Prephenate dehydrogenase
SAIN_RS06155	COG0730	response to heat
SAIN_RS06160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SAIN_RS06165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SAIN_RS06170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SAIN_RS06175	COG0710	3-dehydroquinate dehydratase activity
SAIN_RS06180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SAIN_RS06185	COG1368	sulfuric ester hydrolase activity
SAIN_RS06195	COG0813	purine-nucleoside phosphorylase activity
SAIN_RS06205	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SAIN_RS06210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SAIN_RS06225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SAIN_RS06235	COG1595	DNA-templated transcription, initiation
SAIN_RS06240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SAIN_RS06245	COG0772	Belongs to the SEDS family
SAIN_RS06260	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SAIN_RS06265	COG0406	alpha-ribazole phosphatase activity
SAIN_RS06270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SAIN_RS06300	COG1882	Formate acetyltransferase
SAIN_RS06305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAIN_RS06315	COG1447	Phosphotransferase system cellobiose-specific component IIA
SAIN_RS06325	COG1349	DNA-binding transcription factor activity
SAIN_RS06330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SAIN_RS06335	COG1959	2 iron, 2 sulfur cluster binding
SAIN_RS06350	COG1136	(ABC) transporter
SAIN_RS06355	COG1309	transcriptional regulator
SAIN_RS06375	COG0716	FMN binding
SAIN_RS06380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SAIN_RS06385	COG0254	rRNA binding
SAIN_RS06405	COG1125	glycine betaine transport
SAIN_RS06410	COG1732	Glycine betaine
SAIN_RS06420	COG1573	uracil-dna glycosylase
SAIN_RS06430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAIN_RS06440	COG0322	excinuclease ABC activity
SAIN_RS06445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SAIN_RS06455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SAIN_RS06485	COG1476	TRANSCRIPTIONal
SAIN_RS06500	COG0204	Acyl-transferase
SAIN_RS06505	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SAIN_RS06510	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SAIN_RS06515	COG2827	Endonuclease containing a URI domain
SAIN_RS06520	COG3867	Arabinogalactan endo-beta-1,4-galactanase
SAIN_RS06525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAIN_RS06525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAIN_RS06530	COG1447	Phosphotransferase system cellobiose-specific component IIA
SAIN_RS06535	COG2723	6-phospho-beta-galactosidase activity
SAIN_RS06540	COG3711	transcriptional antiterminator
SAIN_RS06545	COG1755	Isoprenylcysteine carboxyl methyltransferase
SAIN_RS06555	COG3775	system Galactitol-specific IIC component
SAIN_RS06575	COG0698	ribose 5-phosphate isomerase
SAIN_RS06580	COG1349	DNA-binding transcription factor activity
SAIN_RS06590	COG0513	Belongs to the DEAD box helicase family
SAIN_RS06610	COG3620	sequence-specific DNA binding
SAIN_RS06630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SAIN_RS06635	COG1181	Belongs to the D-alanine--D-alanine ligase family
SAIN_RS06640	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SAIN_RS06645	COG0768	penicillin binding
SAIN_RS06655	COG3620	sequence-specific DNA binding
SAIN_RS06660	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
SAIN_RS06670	COG0582	viral genome integration into host DNA
SAIN_RS06675	COG0588	phosphoglycerate mutase activity
SAIN_RS06690	COG1307	EDD domain protein, DegV family
SAIN_RS06695	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SAIN_RS06700	COG4605	iron ion homeostasis
SAIN_RS06705	COG4604	ABC transporter, ATP-binding protein
SAIN_RS06710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SAIN_RS06715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SAIN_RS06720	COG0497	DNA recombination
SAIN_RS06725	COG1438	arginine binding
SAIN_RS06730	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SAIN_RS06740	COG1722	exodeoxyribonuclease VII activity
SAIN_RS06745	COG1570	exodeoxyribonuclease VII activity
SAIN_RS06755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SAIN_RS06760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SAIN_RS06765	COG0577	efflux transmembrane transporter activity
SAIN_RS06770	COG1136	(ABC) transporter
SAIN_RS06795	COG4703	Protein of unknown function (DUF1797)
SAIN_RS06800	COG0542	response to heat
SAIN_RS06815	COG0494	nUDIX hydrolase
SAIN_RS06825	COG0025	NhaP-type Na H and K H
SAIN_RS06835	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SAIN_RS06840	COG1242	4 iron, 4 sulfur cluster binding
SAIN_RS06850	COG0671	phosphoesterase, PA-phosphatase related
SAIN_RS06855	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SAIN_RS06865	COG0569	domain protein
SAIN_RS06870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SAIN_RS06885	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SAIN_RS06890	COG1187	pseudouridine synthase activity
SAIN_RS06895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SAIN_RS06900	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SAIN_RS06905	COG4974	Belongs to the 'phage' integrase family
SAIN_RS06920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SAIN_RS06925	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SAIN_RS06950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SAIN_RS06955	COG1254	Belongs to the acylphosphatase family
SAIN_RS06980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SAIN_RS06995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SAIN_RS07005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SAIN_RS07015	COG1160	GTP binding
SAIN_RS07025	COG1484	DNA-dependent DNA replication
SAIN_RS07035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SAIN_RS07050	COG2190	(PTS) system
SAIN_RS07050	COG1263	PTS System
SAIN_RS07050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAIN_RS07055	COG0745	RESPONSE REGULATOR receiver
SAIN_RS07060	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SAIN_RS07085	COG0501	Belongs to the peptidase M48B family
SAIN_RS07090	COG1704	LemA family
SAIN_RS07095	COG0357	Ribosomal RNA small subunit methyltransferase G
SAIN_RS07100	COG1442	glycosyl transferase family 8
SAIN_RS07105	COG4221	oxidoreductase activity
SAIN_RS07115	COG1122	ATPase activity
SAIN_RS07125	COG4720	Psort location CytoplasmicMembrane, score
SAIN_RS07140	COG2801	Transposase and inactivated derivatives
SAIN_RS07220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SAIN_RS07225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SAIN_RS07230	COG1464	Belongs to the NlpA lipoprotein family
SAIN_RS07235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SAIN_RS07245	COG0659	secondary active sulfate transmembrane transporter activity
SAIN_RS07250	COG1396	sequence-specific DNA binding
SAIN_RS07255	COG0217	transcriptional regulatory protein
SAIN_RS07260	COG1323	Belongs to the UPF0348 family
SAIN_RS07270	COG2226	methyltransferase
SAIN_RS07275	COG0799	negative regulation of ribosome biogenesis
SAIN_RS07280	COG1713	HD superfamily hydrolase involved in NAD metabolism
SAIN_RS07285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SAIN_RS07290	COG1534	Rna-binding protein
SAIN_RS07295	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SAIN_RS07300	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SAIN_RS07315	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAIN_RS07320	COG0154	amidase activity
SAIN_RS07325	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SAIN_RS07330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SAIN_RS07335	COG1335	isochorismatase
SAIN_RS07340	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SAIN_RS07345	COG0436	Aminotransferase
SAIN_RS07350	COG0589	response to stress
SAIN_RS07355	COG0561	phosphatase activity
SAIN_RS07360	COG0252	asparaginase activity
SAIN_RS07365	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SAIN_RS07370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SAIN_RS07375	COG0736	holo-[acyl-carrier-protein] synthase activity
SAIN_RS07380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SAIN_RS07390	COG0531	amino acid
SAIN_RS07395	COG1482	cell wall glycoprotein biosynthetic process
SAIN_RS07400	COG2188	Transcriptional regulator
SAIN_RS07405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAIN_RS07410	COG2723	6-phospho-beta-galactosidase activity
SAIN_RS07415	COG1447	Phosphotransferase system cellobiose-specific component IIA
SAIN_RS07420	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAIN_RS07425	COG1132	(ABC) transporter
SAIN_RS07440	COG0242	peptide deformylase activity
SAIN_RS07445	COG1940	carbohydrate kinase activity
SAIN_RS07450	COG1263	PTS System
SAIN_RS07450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAIN_RS07450	COG2190	(PTS) system
SAIN_RS07455	COG1621	beta-fructofuranosidase activity
SAIN_RS07460	COG1609	Transcriptional regulator
SAIN_RS07465	COG0561	phosphatase activity
SAIN_RS07470	COG4608	Belongs to the ABC transporter superfamily
SAIN_RS07475	COG0444	Belongs to the ABC transporter superfamily
SAIN_RS07480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SAIN_RS07485	COG0601	transmembrane transport
SAIN_RS07490	COG4166	transmembrane transport
SAIN_RS07495	COG4166	transmembrane transport
SAIN_RS07505	COG0504	CTP synthase activity
SAIN_RS07510	COG3343	RNA polymerase activity
SAIN_RS07515	COG0544	peptidyl-prolyl cis-trans isomerase activity
SAIN_RS07520	COG4475	Protein of unknown function (DUF436)
SAIN_RS07525	COG4720	Psort location CytoplasmicMembrane, score
SAIN_RS07530	COG0351	phosphomethylpyrimidine kinase
SAIN_RS07535	COG0101	tRNA pseudouridine synthase activity
SAIN_RS07545	COG0484	heat shock protein binding
SAIN_RS07550	COG0443	Heat shock 70 kDa protein
SAIN_RS07555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SAIN_RS07560	COG1420	regulation of RNA biosynthetic process
SAIN_RS07565	COG0588	phosphoglycerate mutase activity
SAIN_RS07570	COG0588	phosphoglycerate mutase activity
SAIN_RS07575	COG2848	UPF0210 protein
SAIN_RS07580	COG3830	Belongs to the UPF0237 family
SAIN_RS07595	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SAIN_RS07600	COG1215	transferase activity, transferring glycosyl groups
SAIN_RS07610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SAIN_RS07670	COG4974	Belongs to the 'phage' integrase family
SAIN_RS07690	COG2217	Heavy metal translocating P-type atpase
SAIN_RS07700	COG3328	transposase activity
SAIN_RS07715	COG2184	nucleotidyltransferase activity
SAIN_RS07780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SAIN_RS07785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SAIN_RS07795	COG3688	RNA-binding protein containing a PIN domain
SAIN_RS07805	COG3842	ATPase activity
SAIN_RS07815	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SAIN_RS07820	COG0215	cysteine-tRNA ligase activity
SAIN_RS07825	COG1045	serine acetyltransferase
SAIN_RS07830	COG1185	polyribonucleotide nucleotidyltransferase activity
SAIN_RS07835	COG1164	Oligoendopeptidase f
SAIN_RS07850	COG3118	belongs to the thioredoxin family
SAIN_RS07900	COG2176	DNA-directed DNA polymerase activity
SAIN_RS07905	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SAIN_RS07910	COG1523	belongs to the glycosyl hydrolase 13 family
SAIN_RS07925	COG2249	NAD(P)H dehydrogenase (quinone) activity
SAIN_RS07940	COG0561	phosphatase activity
SAIN_RS07960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SAIN_RS07965	COG0006	proline dipeptidase activity
SAIN_RS07975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SAIN_RS07990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SAIN_RS07995	COG0629	single-stranded DNA binding
SAIN_RS08040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SAIN_RS08050	COG1122	ATPase activity
SAIN_RS08075	COG5002	protein histidine kinase activity
SAIN_RS08080	COG0745	RESPONSE REGULATOR receiver
SAIN_RS08085	COG2723	6-phospho-beta-galactosidase activity
SAIN_RS08110	COG0028	Belongs to the TPP enzyme family
SAIN_RS08115	COG1876	peptidase activity
SAIN_RS08145	COG0346	lactoylglutathione lyase activity
SAIN_RS08170	COG2190	(PTS) system
SAIN_RS08170	COG1263	PTS System
SAIN_RS08170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SAIN_RS08185	COG1131	(ABC) transporter
SAIN_RS08195	COG2746	aminoglycoside 3-N-acetyltransferase activity
SAIN_RS08215	COG1447	Phosphotransferase system cellobiose-specific component IIA
SAIN_RS08220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAIN_RS08230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SAIN_RS08235	COG1940	carbohydrate kinase activity
SAIN_RS08250	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAIN_RS08250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SAIN_RS08255	COG0167	dihydroorotate dehydrogenase activity
SAIN_RS08260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SAIN_RS08270	COG0668	transmembrane transport
SAIN_RS08275	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SAIN_RS08280	COG3118	belongs to the thioredoxin family
SAIN_RS08290	COG1193	negative regulation of DNA recombination
SAIN_RS08310	COG0681	Belongs to the peptidase S26 family
SAIN_RS08320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SAIN_RS08325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SAIN_RS08330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SAIN_RS08335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SAIN_RS08360	COG1214	PFAM Peptidase M22, glycoprotease
SAIN_RS08380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SAIN_RS08385	COG0049	tRNA binding
SAIN_RS08390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SAIN_RS08400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SAIN_RS08405	COG3481	metal-dependent phosphohydrolase, HD sub domain
SAIN_RS08415	COG1564	THIamine pyrophosphokinase
SAIN_RS08425	COG1162	GTPase activity
SAIN_RS08440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SAIN_RS08460	COG0084	hydrolase, TatD family'
SAIN_RS08465	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SAIN_RS08485	COG0594	ribonuclease P activity
SAIN_RS08495	COG0166	Belongs to the GPI family
SAIN_RS08520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SAIN_RS08550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SAIN_RS08555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SAIN_RS08570	COG4463	regulation of RNA biosynthetic process
SAIN_RS08585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SAIN_RS08590	COG0052	Belongs to the universal ribosomal protein uS2 family
SAIN_RS08600	COG0203	ribosomal protein L17
SAIN_RS08605	COG0202	RNA polymerase activity
SAIN_RS08610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SAIN_RS08615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SAIN_RS08620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SAIN_RS08625	COG0563	adenylate kinase activity
SAIN_RS08630	COG0201	protein transport
SAIN_RS08635	COG0200	Binds to the 23S rRNA
SAIN_RS08640	COG1841	ribosomal large subunit assembly
SAIN_RS08645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SAIN_RS08655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SAIN_RS08660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SAIN_RS08665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SAIN_RS08670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SAIN_RS08675	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SAIN_RS08680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SAIN_RS08695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SAIN_RS08700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SAIN_RS08705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SAIN_RS08715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SAIN_RS08720	COG0089	rRNA binding
SAIN_RS08725	COG0088	Forms part of the polypeptide exit tunnel
SAIN_RS08730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SAIN_RS08735	COG0051	transcription antitermination factor activity, RNA binding
SAIN_RS08745	COG0572	uridine kinase
SAIN_RS08750	COG0343	queuine tRNA-ribosyltransferase activity
SAIN_RS08765	COG1832	CoA-binding protein
SAIN_RS08770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAIN_RS08770	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SAIN_RS08775	COG5002	protein histidine kinase activity
SAIN_RS08810	COG0438	transferase activity, transferring glycosyl groups
SAIN_RS08820	COG0562	UDP-galactopyranose mutase
SAIN_RS08840	COG1216	Glycosyl transferase, family 2
SAIN_RS08840	COG1442	glycosyl transferase family 8
SAIN_RS08845	COG1442	glycosyl transferase family 8
SAIN_RS08845	COG1216	Glycosyl transferase, family 2
SAIN_RS08875	COG3944	biosynthesis protein
SAIN_RS08880	COG4464	protein tyrosine phosphatase activity
SAIN_RS08890	COG0602	queuosine metabolic process
SAIN_RS08915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SAIN_RS08925	COG0285	dihydrofolate synthase activity
SAIN_RS08930	COG3906	Belongs to the UPF0473 family
SAIN_RS08935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SAIN_RS08940	COG4472	Bacterial protein of unknown function (DUF965)
SAIN_RS08955	COG1393	Belongs to the ArsC family
SAIN_RS08960	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SAIN_RS08965	COG1546	Belongs to the CinA family
SAIN_RS08965	COG1058	Belongs to the CinA family
SAIN_RS08975	COG0519	Catalyzes the synthesis of GMP from XMP
SAIN_RS08980	COG0632	four-way junction helicase activity
SAIN_RS08985	COG3620	sequence-specific DNA binding
SAIN_RS08990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SAIN_RS09005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SAIN_RS09010	COG1438	arginine binding
SAIN_RS09015	COG0018	arginyl-trna synthetase
SAIN_RS09020	COG1780	Probably involved in ribonucleotide reductase function
SAIN_RS09030	COG0058	SHG alpha-glucan phosphorylase activity
SAIN_RS09035	COG1640	4-alpha-glucanotransferase
SAIN_RS09040	COG2182	Extracellular solute-binding protein
SAIN_RS09045	COG1175	transmembrane transport
SAIN_RS09050	COG3833	ABC-type maltose transport systems, permease component
SAIN_RS09055	COG5521	maltodextrose utilization protein MalA
SAIN_RS09060	COG1609	Transcriptional regulator
SAIN_RS09065	COG1523	belongs to the glycosyl hydrolase 13 family
SAIN_RS09070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SAIN_RS09090	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SAIN_RS09095	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SAIN_RS09130	COG1674	ftsk spoiiie
SAIN_RS09145	COG0582	viral genome integration into host DNA
SAIN_RS09155	COG2801	Transposase and inactivated derivatives
SAIN_RS09170	COG2807	transmembrane transport
SAIN_RS09175	COG2094	Belongs to the DNA glycosylase MPG family
SAIN_RS09180	COG0561	phosphatase activity
SAIN_RS09185	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SAIN_RS09190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SAIN_RS09195	COG1696	Membrane protein involved in D-alanine export
SAIN_RS09250	COG0561	phosphatase activity
SAIN_RS09270	COG1011	Hydrolase
SAIN_RS09280	COG0305	Participates in initiation and elongation during chromosome replication
SAIN_RS09295	COG0445	tRNA wobble uridine modification
SAIN_RS09300	COG0482	sulfurtransferase activity
SAIN_RS09310	COG1760	l-serine dehydratase
SAIN_RS09315	COG1760	l-serine dehydratase
SAIN_RS09330	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SAIN_RS09335	COG1122	ATPase activity
SAIN_RS09340	COG1122	ATPase activity
SAIN_RS09345	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SAIN_RS09355	COG0612	Peptidase, M16
SAIN_RS09360	COG0612	Peptidase, M16
SAIN_RS09370	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SAIN_RS09375	COG0517	IMP dehydrogenase activity
SAIN_RS09375	COG0516	GMP reductase activity
SAIN_RS09380	COG0180	Tryptophanyl-tRNA synthetase
SAIN_RS09385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SAIN_RS09390	COG0149	triose-phosphate isomerase activity
SAIN_RS09400	COG0488	(ABC) transporter
SAIN_RS09440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SAIN_RS09445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SAIN_RS09450	COG1475	DNA binding
SAIN_RS09475	COG1368	sulfuric ester hydrolase activity