locus-tag	class	description
SA27298_RS00010	COG0592	DNA-directed DNA polymerase activity
SA27298_RS00025	COG0012	GTP binding
SA27298_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
SA27298_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SA27298_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SA27298_RS00055	COG0037	tRNA processing
SA27298_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SA27298_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SA27298_RS00185	COG1792	Involved in formation and maintenance of cell shape
SA27298_RS00195	COG3942	CHAP domain
SA27298_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SA27298_RS00205	COG0436	Aminotransferase
SA27298_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
SA27298_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SA27298_RS00225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SA27298_RS00240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SA27298_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SA27298_RS00260	COG3942	CHAP domain
SA27298_RS00265	COG0151	Belongs to the GarS family
SA27298_RS00270	COG1683	Conserved Protein
SA27298_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SA27298_RS00315	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SA27298_RS00320	COG2376	Dihydroxyacetone kinase
SA27298_RS00330	COG2376	Dihydroxyacetone kinase
SA27298_RS00335	COG1461	Dihydroxyacetone kinase
SA27298_RS00340	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SA27298_RS00345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SA27298_RS00360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA27298_RS00370	COG3716	PTS system mannose fructose sorbose family IID component
SA27298_RS00380	COG2222	sugar isomerase
SA27298_RS00385	COG3684	Belongs to the aldolase LacD family
SA27298_RS00395	COG2255	four-way junction helicase activity
SA27298_RS00405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SA27298_RS00420	COG1012	belongs to the aldehyde dehydrogenase family
SA27298_RS00420	COG1454	alcohol dehydrogenase
SA27298_RS00425	COG1454	alcohol dehydrogenase
SA27298_RS00435	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SA27298_RS00445	COG1175	transmembrane transport
SA27298_RS00450	COG0395	ABC-type sugar transport system, permease component
SA27298_RS00465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SA27298_RS00485	COG1269	ATP hydrolysis coupled proton transport
SA27298_RS00490	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SA27298_RS00500	COG1527	subunit (C
SA27298_RS00505	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
SA27298_RS00515	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SA27298_RS00520	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SA27298_RS00525	COG1394	ATPase activity, coupled to movement of substances
SA27298_RS00530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SA27298_RS00550	COG3759	membrane
SA27298_RS00555	COG1914	H( )-stimulated, divalent metal cation uptake system
SA27298_RS00580	COG1846	Transcriptional regulator
SA27298_RS00585	COG1121	(ABC) transporter
SA27298_RS00590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SA27298_RS00595	COG0803	Belongs to the bacterial solute-binding protein 9 family
SA27298_RS00595	COG3443	Belongs to the bacterial solute-binding protein 9 family
SA27298_RS00615	COG0564	pseudouridine synthase activity
SA27298_RS00620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SA27298_RS00625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SA27298_RS00780	COG0789	Transcriptional regulator
SA27298_RS00785	COG2081	HI0933 family
SA27298_RS00795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SA27298_RS00800	COG0584	glycerophosphoryl diester phosphodiesterase
SA27298_RS00805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SA27298_RS00810	COG0582	viral genome integration into host DNA
SA27298_RS00870	COG2936	dipeptidyl-peptidase activity
SA27298_RS00875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SA27298_RS00890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SA27298_RS00910	COG1304	FMN binding
SA27298_RS00920	COG3425	synthase
SA27298_RS00935	COG1882	Formate acetyltransferase
SA27298_RS00940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SA27298_RS00945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SA27298_RS00950	COG0681	Belongs to the peptidase S26 family
SA27298_RS00970	COG1193	negative regulation of DNA recombination
SA27298_RS00980	COG3118	belongs to the thioredoxin family
SA27298_RS00985	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SA27298_RS00990	COG0668	transmembrane transport
SA27298_RS01000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SA27298_RS01005	COG0167	dihydroorotate dehydrogenase activity
SA27298_RS01010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SA27298_RS01010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SA27298_RS01050	COG1940	carbohydrate kinase activity
SA27298_RS01055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SA27298_RS01065	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SA27298_RS01070	COG1447	Phosphotransferase system cellobiose-specific component IIA
SA27298_RS01075	COG1263	PTS System
SA27298_RS01075	COG2190	(PTS) system
SA27298_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA27298_RS01105	COG0346	lactoylglutathione lyase activity
SA27298_RS01115	COG0561	phosphatase activity
SA27298_RS01140	COG1876	peptidase activity
SA27298_RS01145	COG0028	Belongs to the TPP enzyme family
SA27298_RS01150	COG1304	FMN binding
SA27298_RS01155	COG2723	6-phospho-beta-galactosidase activity
SA27298_RS01160	COG0745	RESPONSE REGULATOR receiver
SA27298_RS01165	COG5002	protein histidine kinase activity
SA27298_RS01190	COG1122	ATPase activity
SA27298_RS01225	COG0588	phosphoglycerate mutase activity
SA27298_RS01250	COG0629	single-stranded DNA binding
SA27298_RS01255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SA27298_RS01270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SA27298_RS01280	COG0006	proline dipeptidase activity
SA27298_RS01285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SA27298_RS01330	COG0527	aspartate kinase activity
SA27298_RS01335	COG1024	Enoyl-CoA hydratase
SA27298_RS01345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SA27298_RS01355	COG2070	2-Nitropropane dioxygenase
SA27298_RS01360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SA27298_RS01370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SA27298_RS01380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SA27298_RS01385	COG0439	Biotin carboxylase
SA27298_RS01390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SA27298_RS01395	COG0825	malonyl-CoA metabolic process
SA27298_RS01400	COG0586	Pfam SNARE associated Golgi protein
SA27298_RS01415	COG3716	PTS system mannose fructose sorbose family IID component
SA27298_RS01420	COG3715	PTS system
SA27298_RS01430	COG0561	phosphatase activity
SA27298_RS01440	COG2252	PERMEase
SA27298_RS01445	COG0802	atpase or kinase
SA27298_RS01455	COG1316	TRANSCRIPTIONal
SA27298_RS01465	COG0537	adenosine 5'-monophosphoramidase activity
SA27298_RS01470	COG1131	(ABC) transporter
SA27298_RS01480	COG0510	thiamine kinase activity
SA27298_RS01485	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SA27298_RS01495	COG0779	Required for maturation of 30S ribosomal subunits
SA27298_RS01500	COG0195	Participates in both transcription termination and antitermination
SA27298_RS01505	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SA27298_RS01520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SA27298_RS01525	COG1283	sodium-dependent phosphate transmembrane transporter activity
SA27298_RS01540	COG0656	L-ascorbic acid biosynthetic process
SA27298_RS01570	COG0752	glycyl-tRNA synthetase alpha subunit
SA27298_RS01575	COG0751	glycine-tRNA ligase activity
SA27298_RS01590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SA27298_RS01600	COG0275	rRNA processing
SA27298_RS01610	COG0768	penicillin binding
SA27298_RS01615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SA27298_RS01620	COG4166	transmembrane transport
SA27298_RS01630	COG0191	fructose-bisphosphate aldolase activity
SA27298_RS01655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SA27298_RS01665	COG1461	Dihydroxyacetone kinase
SA27298_RS01715	COG1131	(ABC) transporter
SA27298_RS01745	COG1126	abc transporter atp-binding protein
SA27298_RS01750	COG0765	amino acid transport
SA27298_RS01760	COG1968	undecaprenyl-diphosphatase activity
SA27298_RS01765	COG4862	establishment of competence for transformation
SA27298_RS01770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SA27298_RS01780	COG0719	Fe-S assembly protein
SA27298_RS01785	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SA27298_RS01795	COG1686	Belongs to the peptidase S11 family
SA27298_RS01800	COG0513	Belongs to the DEAD box helicase family
SA27298_RS01810	COG1126	abc transporter atp-binding protein
SA27298_RS01820	COG0492	ferredoxin-NADP+ reductase activity
SA27298_RS01825	COG1113	amino acid transport
SA27298_RS01830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SA27298_RS01835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SA27298_RS01840	COG3579	cysteine-type endopeptidase activity
SA27298_RS01845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SA27298_RS01850	COG3331	DNA recombination
SA27298_RS01855	COG4474	Belongs to the UPF0398 family
SA27298_RS01860	COG3599	regulation of cell shape
SA27298_RS01870	COG0116	Belongs to the methyltransferase superfamily
SA27298_RS01880	COG0450	alkyl hydroperoxide reductase
SA27298_RS01885	COG3634	alkyl hydroperoxide reductase activity
SA27298_RS01895	COG1418	mRNA catabolic process
SA27298_RS01900	COG0194	GDP metabolic process
SA27298_RS01905	COG1758	RNA polymerase activity
SA27298_RS01910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SA27298_RS01915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SA27298_RS01920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SA27298_RS01920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SA27298_RS01925	COG0631	protein serine/threonine phosphatase activity
SA27298_RS01930	COG2815	serine threonine protein kinase
SA27298_RS01930	COG0515	serine threonine protein kinase
SA27298_RS01955	COG1185	polyribonucleotide nucleotidyltransferase activity
SA27298_RS01965	COG3557	Belongs to the UPF0374 family
SA27298_RS01970	COG2137	regulation of response to DNA damage stimulus
SA27298_RS01975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SA27298_RS01985	COG2070	2-Nitropropane dioxygenase
SA27298_RS02005	COG0519	Catalyzes the synthesis of GMP from XMP
SA27298_RS02035	COG1739	Uncharacterized protein family UPF0029
SA27298_RS02040	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SA27298_RS02045	COG1040	competence protein
SA27298_RS02055	COG0742	ribosomal rna small subunit methyltransferase
SA27298_RS02060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SA27298_RS02065	COG3480	Lon protease (S16) C-terminal proteolytic domain
SA27298_RS02070	COG4470	Protein conserved in bacteria
SA27298_RS02075	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SA27298_RS02085	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SA27298_RS02105	COG1187	pseudouridine synthase activity
SA27298_RS02110	COG1217	gtp-binding protein TYPA
SA27298_RS02120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SA27298_RS02125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SA27298_RS02130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SA27298_RS02145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SA27298_RS02150	COG1799	cell septum assembly
SA27298_RS02165	COG3599	regulation of cell shape
SA27298_RS02170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SA27298_RS02175	COG1846	Transcriptional regulator
SA27298_RS02185	COG0628	permease
SA27298_RS02195	COG1253	flavin adenine dinucleotide binding
SA27298_RS02200	COG2188	Transcriptional regulator
SA27298_RS02205	COG1263	PTS System
SA27298_RS02205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA27298_RS02210	COG0366	Alpha amylase catalytic
SA27298_RS02220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SA27298_RS02245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SA27298_RS02250	COG2244	polysaccharide biosynthetic process
SA27298_RS02255	COG0626	cystathionine gamma-synthase activity
SA27298_RS02260	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SA27298_RS02265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SA27298_RS02270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SA27298_RS02275	COG0740	serine-type endopeptidase activity
SA27298_RS02295	COG4177	L-phenylalanine transmembrane transporter activity
SA27298_RS02310	COG0517	IMP dehydrogenase activity
SA27298_RS02315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SA27298_RS02320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SA27298_RS02325	COG0470	DNA polymerase III
SA27298_RS02330	COG4467	Involved in initiation control of chromosome replication
SA27298_RS02340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SA27298_RS02345	COG1393	Belongs to the ArsC family
SA27298_RS02350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SA27298_RS02355	COG0708	Exodeoxyribonuclease III
SA27298_RS02370	COG0640	Transcriptional regulator
SA27298_RS02395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SA27298_RS02395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SA27298_RS02405	COG0745	RESPONSE REGULATOR receiver
SA27298_RS02410	COG0642	Histidine kinase
SA27298_RS02420	COG1136	(ABC) transporter
SA27298_RS02425	COG0577	efflux transmembrane transporter activity
SA27298_RS02450	COG1136	(ABC) transporter
SA27298_RS02455	COG0577	efflux transmembrane transporter activity
SA27298_RS02460	COG0531	amino acid
SA27298_RS02490	COG1028	Short-chain dehydrogenase reductase Sdr
SA27298_RS02505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SA27298_RS02520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SA27298_RS02530	COG0488	(ABC) transporter
SA27298_RS02535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SA27298_RS02540	COG1983	PspC domain protein
SA27298_RS02545	COG0697	spore germination
SA27298_RS02545	COG1674	ftsk spoiiie
SA27298_RS02550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SA27298_RS02565	COG0081	regulation of translation
SA27298_RS02570	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SA27298_RS02575	COG0372	Belongs to the citrate synthase family
SA27298_RS02580	COG0538	isocitrate dehydrogenase activity
SA27298_RS02585	COG0528	UMP kinase activity
SA27298_RS02590	COG0233	cytoplasmic translational termination
SA27298_RS02595	COG2996	Protein conserved in bacteria
SA27298_RS02600	COG1466	dna polymerase III delta subunit
SA27298_RS02605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SA27298_RS02610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SA27298_RS02615	COG2274	protein secretion by the type I secretion system
SA27298_RS02650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SA27298_RS02655	COG0549	Belongs to the carbamate kinase family
SA27298_RS02660	COG1288	antiporter activity
SA27298_RS02665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SA27298_RS02670	COG1438	arginine binding
SA27298_RS02675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SA27298_RS02680	COG0363	glucosamine-6-phosphate deaminase activity
SA27298_RS02705	COG4122	O-methyltransferase activity
SA27298_RS02710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SA27298_RS02720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SA27298_RS02730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SA27298_RS02740	COG2274	protein secretion by the type I secretion system
SA27298_RS02745	COG2348	transferase activity, transferring amino-acyl groups
SA27298_RS02750	COG2348	transferase activity, transferring amino-acyl groups
SA27298_RS02760	COG1078	dGTPase activity
SA27298_RS02785	COG0561	phosphatase activity
SA27298_RS02795	COG2884	Cell division ATP-binding protein ftsE
SA27298_RS02800	COG2177	Part of the ABC transporter FtsEX involved in
SA27298_RS02810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SA27298_RS02810	COG1199	ATP-dependent helicase activity
SA27298_RS02820	COG0772	Belongs to the SEDS family
SA27298_RS02825	COG0693	protein deglycase activity
SA27298_RS02835	COG0187	DNA topoisomerase II activity
SA27298_RS02840	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SA27298_RS02845	COG2706	6-phosphogluconolactonase activity
SA27298_RS02850	COG0745	RESPONSE REGULATOR receiver
SA27298_RS02855	COG3850	Histidine kinase
SA27298_RS02855	COG5002	protein histidine kinase activity
SA27298_RS02860	COG0628	permease
SA27298_RS02870	COG0028	Belongs to the TPP enzyme family
SA27298_RS02875	COG3527	Alpha-acetolactate decarboxylase
SA27298_RS02880	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SA27298_RS02895	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SA27298_RS02905	COG4443	Transcriptional Coactivator p15 (PC4)
SA27298_RS02910	COG4152	abc transporter atp-binding protein
SA27298_RS02915	COG1668	transmembrane transport
SA27298_RS02920	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SA27298_RS02925	COG1074	ATP-dependent DNA helicase activity
SA27298_RS02930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SA27298_RS02935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SA27298_RS02940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SA27298_RS02945	COG0297	glycogen (starch) synthase activity
SA27298_RS02950	COG0058	SHG alpha-glucan phosphorylase activity
SA27298_RS02960	COG0356	it plays a direct role in the translocation of protons across the membrane
SA27298_RS02965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SA27298_RS02970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SA27298_RS02975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SA27298_RS02980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SA27298_RS03000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SA27298_RS03020	COG1132	(ABC) transporter
SA27298_RS03045	COG1346	cytolysis
SA27298_RS03050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SA27298_RS03065	COG2384	SAM-dependent methyltransferase
SA27298_RS03070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SA27298_RS03075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SA27298_RS03080	COG1051	belongs to the nudix hydrolase family
SA27298_RS03090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SA27298_RS03100	COG1088	dTDP-glucose 4,6-dehydratase activity
SA27298_RS03105	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SA27298_RS03110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SA27298_RS03115	COG0463	Glycosyl transferase, family 2
SA27298_RS03140	COG0463	Glycosyl transferase, family 2
SA27298_RS03145	COG1091	dTDP-4-dehydrorhamnose reductase activity
SA27298_RS03180	COG1368	sulfuric ester hydrolase activity
SA27298_RS03185	COG0006	proline dipeptidase activity
SA27298_RS03190	COG1609	Transcriptional regulator
SA27298_RS03200	COG0438	transferase activity, transferring glycosyl groups
SA27298_RS03210	COG0745	RESPONSE REGULATOR receiver
SA27298_RS03215	COG5002	protein histidine kinase activity
SA27298_RS03220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SA27298_RS03230	COG0571	ribonuclease III activity
SA27298_RS03235	COG1196	nuclear chromosome segregation
SA27298_RS03240	COG0561	phosphatase activity
SA27298_RS03245	COG0561	phosphatase activity
SA27298_RS03250	COG0552	protein localization to endoplasmic reticulum
SA27298_RS03255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SA27298_RS03260	COG0477	Major facilitator Superfamily
SA27298_RS03265	COG3689	TIGRFAM TIGR03943 family protein
SA27298_RS03270	COG0701	Predicted permease
SA27298_RS03280	COG2183	response to ionizing radiation
SA27298_RS03285	COG3091	SprT-like family
SA27298_RS03300	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SA27298_RS03305	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SA27298_RS03330	COG0826	peptidase U32
SA27298_RS03355	COG0488	(ABC) transporter
SA27298_RS03365	COG2814	Major facilitator Superfamily
SA27298_RS03370	COG3442	glutamine amidotransferase
SA27298_RS03375	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SA27298_RS03380	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SA27298_RS03390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SA27298_RS03395	COG0560	Phosphoserine phosphatase
SA27298_RS03420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SA27298_RS03430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SA27298_RS03440	COG0346	lactoylglutathione lyase activity
SA27298_RS03445	COG0726	polysaccharide deacetylase
SA27298_RS03460	COG0572	uridine kinase
SA27298_RS03470	COG2195	Cleaves the N-terminal amino acid of tripeptides
SA27298_RS03475	COG0561	phosphatase activity
SA27298_RS03480	COG0481	GTPase activity
SA27298_RS03490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SA27298_RS03495	COG3842	ATPase activity
SA27298_RS03500	COG1176	ABC-type spermidine putrescine transport system, permease component I
SA27298_RS03505	COG1177	transmembrane transport
SA27298_RS03520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SA27298_RS03520	COG0574	Belongs to the PEP-utilizing enzyme family
SA27298_RS03525	COG0517	IMP dehydrogenase activity
SA27298_RS03530	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SA27298_RS03535	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SA27298_RS03540	COG1104	cysteine desulfurase activity
SA27298_RS03545	COG0301	tRNA thio-modification
SA27298_RS03550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SA27298_RS03560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SA27298_RS03575	COG0425	Belongs to the sulfur carrier protein TusA family
SA27298_RS03575	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SA27298_RS03580	COG0446	pyridine nucleotide-disulphide oxidoreductase
SA27298_RS03595	COG1937	Protein conserved in bacteria
SA27298_RS03600	COG0583	DNA-binding transcription factor activity
SA27298_RS03610	COG0564	pseudouridine synthase activity
SA27298_RS03615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SA27298_RS03620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SA27298_RS03625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SA27298_RS03630	COG2824	Alkylphosphonate utilization operon protein PhnA
SA27298_RS03670	COG0038	chloride channel
SA27298_RS03675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SA27298_RS03680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SA27298_RS03695	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SA27298_RS03700	COG1388	LysM domain
SA27298_RS03700	COG1705	Flagellar rod assembly protein muramidase FlgJ
SA27298_RS03710	COG1132	(ABC) transporter
SA27298_RS03715	COG0488	(ABC) transporter
SA27298_RS03735	COG0556	nucleotide-excision repair
SA27298_RS03745	COG1131	(ABC) transporter
SA27298_RS03755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SA27298_RS03765	COG1051	belongs to the nudix hydrolase family
SA27298_RS03770	COG0647	UMP catabolic process
SA27298_RS03790	COG1660	Displays ATPase and GTPase activities
SA27298_RS03795	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SA27298_RS03800	COG1481	regulation of sporulation
SA27298_RS03805	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SA27298_RS03815	COG0540	Belongs to the ATCase OTCase family
SA27298_RS03820	COG0505	Belongs to the CarA family
SA27298_RS03825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SA27298_RS03830	COG1940	carbohydrate kinase activity
SA27298_RS03865	COG1674	ftsk spoiiie
SA27298_RS03920	COG0745	RESPONSE REGULATOR receiver
SA27298_RS03925	COG5002	protein histidine kinase activity
SA27298_RS03935	COG4187	Peptidase family M20/M25/M40
SA27298_RS03945	COG0268	Binds directly to 16S ribosomal RNA
SA27298_RS03950	COG1072	(Pantothenic acid kinase))
SA27298_RS03955	COG2813	Specifically methylates the guanine in position
SA27298_RS03965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SA27298_RS03970	COG0295	cytidine deaminase activity
SA27298_RS03975	COG1744	ABC transporter substrate-binding protein PnrA-like
SA27298_RS03980	COG3845	ABC transporter
SA27298_RS03985	COG4603	Belongs to the binding-protein-dependent transport system permease family
SA27298_RS03990	COG1079	Belongs to the binding-protein-dependent transport system permease family
SA27298_RS03995	COG1272	protein, Hemolysin III
SA27298_RS04005	COG3022	response to hydroperoxide
SA27298_RS04015	COG1846	Transcriptional regulator
SA27298_RS04025	COG0436	Aminotransferase
SA27298_RS04035	COG0017	Asparaginyl-tRNA synthetase
SA27298_RS04040	COG2814	Major facilitator Superfamily
SA27298_RS04090	COG2131	deaminase
SA27298_RS04100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SA27298_RS04105	COG0187	DNA topoisomerase II activity
SA27298_RS04125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SA27298_RS04130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SA27298_RS04150	COG0539	negative regulation of cytoplasmic translation
SA27298_RS04165	COG0039	L-malate dehydrogenase activity
SA27298_RS04170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SA27298_RS04175	COG3764	Sortase (surface protein transpeptidase)
SA27298_RS04180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SA27298_RS04185	COG1960	acyl-CoA dehydrogenase activity
SA27298_RS04190	COG1250	3-hydroxyacyl-CoA dehydrogenase
SA27298_RS04195	COG0183	Belongs to the thiolase family
SA27298_RS04200	COG1024	Enoyl-CoA hydratase
SA27298_RS04210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SA27298_RS04215	COG0583	DNA-binding transcription factor activity
SA27298_RS04220	COG1960	acyl-CoA dehydrogenase activity
SA27298_RS04225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SA27298_RS04230	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SA27298_RS04235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SA27298_RS04240	COG3711	transcriptional antiterminator
SA27298_RS04245	COG0110	maltose O-acetyltransferase activity
SA27298_RS04250	COG0758	DNA mediated transformation
SA27298_RS04255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SA27298_RS04260	COG0135	phosphoribosylanthranilate isomerase activity
SA27298_RS04265	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SA27298_RS04285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SA27298_RS04290	COG0022	dehydrogenase e1 component
SA27298_RS04295	COG0508	dehydrogenase complex catalyzes the overall conversion of
SA27298_RS04300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SA27298_RS04305	COG0095	Lipoate-protein ligase
SA27298_RS04310	COG1028	Short-chain dehydrogenase reductase Sdr
SA27298_RS04315	COG4974	Belongs to the 'phage' integrase family
SA27298_RS04320	COG1136	(ABC) transporter
SA27298_RS04325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SA27298_RS04335	COG2188	Transcriptional regulator
SA27298_RS04400	COG0741	lytic transglycosylase activity
SA27298_RS04410	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SA27298_RS04420	COG2890	protein-(glutamine-N5) methyltransferase activity
SA27298_RS04430	COG1435	thymidine kinase activity
SA27298_RS04435	COG1942	4-Oxalocrotonate Tautomerase
SA27298_RS04440	COG0534	Mate efflux family protein
SA27298_RS04445	COG2233	PERMEase
SA27298_RS04450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SA27298_RS04480	COG0745	RESPONSE REGULATOR receiver
SA27298_RS04485	COG2205	protein histidine kinase activity
SA27298_RS04505	COG1053	succinate dehydrogenase
SA27298_RS04505	COG0431	NADPH-dependent FMN reductase
SA27298_RS04505	COG3976	FMN-binding domain protein
SA27298_RS04510	COG4555	ABC transporter
SA27298_RS04525	COG2972	Histidine kinase
SA27298_RS04530	COG2207	Transcriptional regulator
SA27298_RS04530	COG4753	response regulator
SA27298_RS04535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SA27298_RS04535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SA27298_RS04540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SA27298_RS04545	COG0785	Cytochrome C biogenesis protein
SA27298_RS04550	COG1114	Component of the transport system for branched-chain amino acids
SA27298_RS04555	COG2151	metal-sulfur cluster biosynthetic enzyme
SA27298_RS04560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SA27298_RS04565	COG0358	DNA primase activity
SA27298_RS04570	COG1970	mechanosensitive ion channel activity
SA27298_RS04575	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SA27298_RS04590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SA27298_RS04595	COG1132	(ABC) transporter
SA27298_RS04600	COG1132	(ABC) transporter
SA27298_RS04605	COG2315	Protein conserved in bacteria
SA27298_RS04610	COG3142	Participates in the control of copper homeostasis
SA27298_RS04625	COG1827	regulation of RNA biosynthetic process
SA27298_RS04630	COG1837	Belongs to the UPF0109 family
SA27298_RS04635	COG0228	four-way junction DNA binding
SA27298_RS04640	COG1523	belongs to the glycosyl hydrolase 13 family
SA27298_RS04645	COG1597	lipid kinase activity
SA27298_RS04650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SA27298_RS04655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SA27298_RS04660	COG4708	membrane
SA27298_RS04665	COG2246	polysaccharide biosynthetic process
SA27298_RS04675	COG1846	Transcriptional regulator
SA27298_RS04680	COG2207	Transcriptional regulator
SA27298_RS04685	COG2273	Hydrolase Family 16
SA27298_RS04695	COG0395	ABC-type sugar transport system, permease component
SA27298_RS04725	COG0024	Methionine aminopeptidase
SA27298_RS04730	COG4109	DRTGG domain
SA27298_RS04740	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SA27298_RS04745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SA27298_RS04750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SA27298_RS04755	COG1051	belongs to the nudix hydrolase family
SA27298_RS04760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SA27298_RS04775	COG0658	competence protein
SA27298_RS04775	COG2333	competence protein COMEC
SA27298_RS04780	COG1555	photosystem II stabilization
SA27298_RS04790	COG0557	exoribonuclease II activity
SA27298_RS04800	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SA27298_RS04805	COG2814	Major facilitator Superfamily
SA27298_RS04810	COG0237	dephospho-CoA kinase activity
SA27298_RS04815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SA27298_RS04840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SA27298_RS04845	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SA27298_RS04850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SA27298_RS04855	COG1132	(ABC) transporter
SA27298_RS04860	COG1132	(ABC) transporter
SA27298_RS04875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SA27298_RS04880	COG0686	Belongs to the AlaDH PNT family
SA27298_RS04895	COG1702	phosphate starvation-inducible protein PhoH
SA27298_RS04900	COG4479	Belongs to the UPF0346 family
SA27298_RS04915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SA27298_RS04925	COG0284	orotidine-5'-phosphate decarboxylase activity
SA27298_RS04930	COG0167	dihydroorotate dehydrogenase activity
SA27298_RS04935	COG0543	2 iron, 2 sulfur cluster binding
SA27298_RS04965	COG0583	DNA-binding transcription factor activity
SA27298_RS04970	COG2814	Major facilitator Superfamily
SA27298_RS04975	COG0583	DNA-binding transcription factor activity
SA27298_RS04985	COG0656	L-ascorbic acid biosynthetic process
SA27298_RS05005	COG0083	homoserine kinase activity
SA27298_RS05015	COG0726	polysaccharide deacetylase
SA27298_RS05025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SA27298_RS05035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SA27298_RS05040	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SA27298_RS05045	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SA27298_RS05050	COG0366	Alpha amylase catalytic
SA27298_RS05055	COG0395	ABC-type sugar transport system, permease component
SA27298_RS05060	COG1175	transmembrane transport
SA27298_RS05065	COG1653	transport
SA27298_RS05070	COG3345	alpha-galactosidase
SA27298_RS05075	COG2207	Transcriptional regulator
SA27298_RS05080	COG1609	Transcriptional regulator
SA27298_RS05085	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SA27298_RS05085	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SA27298_RS05100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SA27298_RS05105	COG1956	GAF domain-containing protein
SA27298_RS05120	COG3443	Belongs to the bacterial solute-binding protein 9 family
SA27298_RS05120	COG0803	Belongs to the bacterial solute-binding protein 9 family
SA27298_RS05125	COG0336	Belongs to the RNA methyltransferase TrmD family
SA27298_RS05130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SA27298_RS05150	COG0222	ribosome binding
SA27298_RS05155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SA27298_RS05160	COG3708	Transcriptional regulator
SA27298_RS05160	COG2207	Transcriptional regulator
SA27298_RS05170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SA27298_RS05175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SA27298_RS05190	COG1247	-acetyltransferase
SA27298_RS05195	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SA27298_RS05205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SA27298_RS05210	COG4684	Psort location CytoplasmicMembrane, score
SA27298_RS05215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SA27298_RS05230	COG0280	phosphate acetyltransferase
SA27298_RS05235	COG0564	pseudouridine synthase activity
SA27298_RS05240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SA27298_RS05245	COG2357	RelA SpoT domain protein
SA27298_RS05255	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SA27298_RS05260	COG1104	cysteine desulfurase activity
SA27298_RS05275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SA27298_RS05280	COG2003	Belongs to the UPF0758 family
SA27298_RS05285	COG0704	Plays a role in the regulation of phosphate uptake
SA27298_RS05290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SA27298_RS05295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SA27298_RS05300	COG0581	inorganic phosphate transmembrane transporter activity
SA27298_RS05305	COG0573	inorganic phosphate transmembrane transporter activity
SA27298_RS05315	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SA27298_RS05315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SA27298_RS05320	COG0483	inositol monophosphate 1-phosphatase activity
SA27298_RS05325	COG4476	Belongs to the UPF0223 family
SA27298_RS05330	COG1393	Belongs to the ArsC family
SA27298_RS05335	COG0196	riboflavin kinase activity
SA27298_RS05340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SA27298_RS05350	COG1132	(ABC) transporter
SA27298_RS05355	COG2375	cellular response to nickel ion
SA27298_RS05355	COG1132	(ABC) transporter
SA27298_RS05360	COG2378	regulation of single-species biofilm formation
SA27298_RS05370	COG0210	DNA helicase
SA27298_RS05375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SA27298_RS05385	COG1126	abc transporter atp-binding protein
SA27298_RS05390	COG0765	amino acid transport
SA27298_RS05400	COG0469	pyruvate kinase activity
SA27298_RS05405	COG0205	6-phosphofructokinase activity
SA27298_RS05415	COG1725	Transcriptional regulator
SA27298_RS05420	COG1131	(ABC) transporter
SA27298_RS05430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SA27298_RS05430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SA27298_RS05445	COG0300	oxidoreductase activity
SA27298_RS05465	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SA27298_RS05470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SA27298_RS05480	COG0577	efflux transmembrane transporter activity
SA27298_RS05485	COG1136	(ABC) transporter
SA27298_RS05495	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SA27298_RS05500	COG1268	BioY protein
SA27298_RS05515	COG1011	Hydrolase
SA27298_RS05525	COG2723	6-phospho-beta-galactosidase activity
SA27298_RS05530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA27298_RS05530	COG1263	PTS System
SA27298_RS05530	COG2190	(PTS) system
SA27298_RS05555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SA27298_RS05555	COG0072	phenylalanine-tRNA ligase activity
SA27298_RS05570	COG0488	(ABC) transporter
SA27298_RS05575	COG0617	tRNA 3'-terminal CCA addition
SA27298_RS05580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SA27298_RS05585	COG1307	EDD domain protein, DegV family
SA27298_RS05595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SA27298_RS05595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SA27298_RS05595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SA27298_RS05600	COG1105	Belongs to the carbohydrate kinase PfkB family
SA27298_RS05605	COG1349	DNA-binding transcription factor activity
SA27298_RS05615	COG0492	ferredoxin-NADP+ reductase activity
SA27298_RS05620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SA27298_RS05665	COG0842	Transport permease protein
SA27298_RS05665	COG1129	ABC transporter
SA27298_RS05670	COG1725	Transcriptional regulator
SA27298_RS05685	COG0556	nucleotide-excision repair
SA27298_RS05725	COG0551	DNA topoisomerase type I activity
SA27298_RS05725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SA27298_RS05790	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SA27298_RS05870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SA27298_RS05895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SA27298_RS05905	COG0077	Prephenate dehydratase
SA27298_RS05910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SA27298_RS05915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SA27298_RS05925	COG3679	Belongs to the UPF0342 family
SA27298_RS05930	COG0287	Prephenate dehydrogenase
SA27298_RS05940	COG0730	response to heat
SA27298_RS05945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SA27298_RS05950	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SA27298_RS05955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SA27298_RS05960	COG0710	3-dehydroquinate dehydratase activity
SA27298_RS05965	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SA27298_RS05970	COG1368	sulfuric ester hydrolase activity
SA27298_RS05980	COG0813	purine-nucleoside phosphorylase activity
SA27298_RS05990	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SA27298_RS05995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SA27298_RS06010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SA27298_RS06020	COG1595	DNA-templated transcription, initiation
SA27298_RS06025	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SA27298_RS06030	COG0772	Belongs to the SEDS family
SA27298_RS06045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SA27298_RS06050	COG0406	alpha-ribazole phosphatase activity
SA27298_RS06055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SA27298_RS06095	COG1882	Formate acetyltransferase
SA27298_RS06100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SA27298_RS06110	COG1447	Phosphotransferase system cellobiose-specific component IIA
SA27298_RS06120	COG1349	DNA-binding transcription factor activity
SA27298_RS06125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SA27298_RS06130	COG1959	2 iron, 2 sulfur cluster binding
SA27298_RS06145	COG1136	(ABC) transporter
SA27298_RS06150	COG1309	transcriptional regulator
SA27298_RS06175	COG1518	maintenance of DNA repeat elements
SA27298_RS06180	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SA27298_RS06190	COG0716	FMN binding
SA27298_RS06195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SA27298_RS06200	COG0254	rRNA binding
SA27298_RS06215	COG1063	alcohol dehydrogenase
SA27298_RS06220	COG1125	glycine betaine transport
SA27298_RS06225	COG1732	Glycine betaine
SA27298_RS06235	COG1573	uracil-dna glycosylase
SA27298_RS06245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SA27298_RS06255	COG0322	excinuclease ABC activity
SA27298_RS06260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SA27298_RS06270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SA27298_RS06280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SA27298_RS06295	COG1476	TRANSCRIPTIONal
SA27298_RS06310	COG0204	Acyl-transferase
SA27298_RS06315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SA27298_RS06320	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SA27298_RS06325	COG2827	Endonuclease containing a URI domain
SA27298_RS06330	COG3867	Arabinogalactan endo-beta-1,4-galactanase
SA27298_RS06335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SA27298_RS06335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SA27298_RS06340	COG1447	Phosphotransferase system cellobiose-specific component IIA
SA27298_RS06345	COG2723	6-phospho-beta-galactosidase activity
SA27298_RS06350	COG3711	transcriptional antiterminator
SA27298_RS06355	COG1755	Isoprenylcysteine carboxyl methyltransferase
SA27298_RS06365	COG3775	system Galactitol-specific IIC component
SA27298_RS06385	COG0698	ribose 5-phosphate isomerase
SA27298_RS06390	COG1349	DNA-binding transcription factor activity
SA27298_RS06400	COG0513	Belongs to the DEAD box helicase family
SA27298_RS06420	COG3620	sequence-specific DNA binding
SA27298_RS06440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SA27298_RS06445	COG1181	Belongs to the D-alanine--D-alanine ligase family
SA27298_RS06450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SA27298_RS06455	COG0768	penicillin binding
SA27298_RS06460	COG0588	phosphoglycerate mutase activity
SA27298_RS06475	COG1307	EDD domain protein, DegV family
SA27298_RS06480	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SA27298_RS06485	COG4605	iron ion homeostasis
SA27298_RS06490	COG4604	ABC transporter, ATP-binding protein
SA27298_RS06495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SA27298_RS06500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SA27298_RS06505	COG0497	DNA recombination
SA27298_RS06510	COG1438	arginine binding
SA27298_RS06515	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SA27298_RS06525	COG1722	exodeoxyribonuclease VII activity
SA27298_RS06530	COG1570	exodeoxyribonuclease VII activity
SA27298_RS06545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SA27298_RS06550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SA27298_RS06555	COG0577	efflux transmembrane transporter activity
SA27298_RS06560	COG1136	(ABC) transporter
SA27298_RS06590	COG4703	Protein of unknown function (DUF1797)
SA27298_RS06595	COG0542	response to heat
SA27298_RS06610	COG0494	nUDIX hydrolase
SA27298_RS06620	COG0025	NhaP-type Na H and K H
SA27298_RS06630	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SA27298_RS06635	COG1242	4 iron, 4 sulfur cluster binding
SA27298_RS06640	COG3695	enzyme binding
SA27298_RS06660	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SA27298_RS06690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SA27298_RS06695	COG1187	pseudouridine synthase activity
SA27298_RS06700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SA27298_RS06705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SA27298_RS06710	COG4974	Belongs to the 'phage' integrase family
SA27298_RS06725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SA27298_RS06730	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SA27298_RS06755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SA27298_RS06760	COG1254	Belongs to the acylphosphatase family
SA27298_RS06780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SA27298_RS06795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SA27298_RS06805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SA27298_RS06810	COG1160	GTP binding
SA27298_RS06820	COG1484	DNA-dependent DNA replication
SA27298_RS06830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SA27298_RS06845	COG2190	(PTS) system
SA27298_RS06845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA27298_RS06845	COG1263	PTS System
SA27298_RS06855	COG3843	relaxase mobilization nuclease domain protein
SA27298_RS06900	COG3942	CHAP domain
SA27298_RS06900	COG1388	LysM domain
SA27298_RS06960	COG3620	sequence-specific DNA binding
SA27298_RS06995	COG0745	RESPONSE REGULATOR receiver
SA27298_RS07000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SA27298_RS07025	COG0501	Belongs to the peptidase M48B family
SA27298_RS07030	COG1704	LemA family
SA27298_RS07035	COG0357	Ribosomal RNA small subunit methyltransferase G
SA27298_RS07040	COG1442	glycosyl transferase family 8
SA27298_RS07045	COG4221	oxidoreductase activity
SA27298_RS07055	COG1122	ATPase activity
SA27298_RS07080	COG4720	Psort location CytoplasmicMembrane, score
SA27298_RS07160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SA27298_RS07165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SA27298_RS07170	COG1464	Belongs to the NlpA lipoprotein family
SA27298_RS07175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SA27298_RS07185	COG0659	secondary active sulfate transmembrane transporter activity
SA27298_RS07190	COG1396	sequence-specific DNA binding
SA27298_RS07195	COG0217	transcriptional regulatory protein
SA27298_RS07200	COG1323	Belongs to the UPF0348 family
SA27298_RS07210	COG2226	methyltransferase
SA27298_RS07215	COG0799	negative regulation of ribosome biogenesis
SA27298_RS07220	COG1713	HD superfamily hydrolase involved in NAD metabolism
SA27298_RS07225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SA27298_RS07230	COG1534	Rna-binding protein
SA27298_RS07235	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SA27298_RS07240	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SA27298_RS07255	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SA27298_RS07260	COG0154	amidase activity
SA27298_RS07265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SA27298_RS07275	COG3843	relaxase mobilization nuclease domain protein
SA27298_RS07320	COG3942	CHAP domain
SA27298_RS07320	COG1388	LysM domain
SA27298_RS07380	COG3620	sequence-specific DNA binding
SA27298_RS07415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SA27298_RS07420	COG1335	isochorismatase
SA27298_RS07425	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SA27298_RS07430	COG0436	Aminotransferase
SA27298_RS07435	COG0589	response to stress
SA27298_RS07440	COG0561	phosphatase activity
SA27298_RS07445	COG0252	asparaginase activity
SA27298_RS07450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SA27298_RS07455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SA27298_RS07460	COG0736	holo-[acyl-carrier-protein] synthase activity
SA27298_RS07465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SA27298_RS07475	COG0531	amino acid
SA27298_RS07480	COG1482	cell wall glycoprotein biosynthetic process
SA27298_RS07485	COG2188	Transcriptional regulator
SA27298_RS07490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SA27298_RS07495	COG2723	6-phospho-beta-galactosidase activity
SA27298_RS07500	COG1447	Phosphotransferase system cellobiose-specific component IIA
SA27298_RS07505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SA27298_RS07510	COG1132	(ABC) transporter
SA27298_RS07525	COG0242	peptide deformylase activity
SA27298_RS07530	COG1940	carbohydrate kinase activity
SA27298_RS07535	COG2190	(PTS) system
SA27298_RS07535	COG1263	PTS System
SA27298_RS07535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA27298_RS07540	COG1621	beta-fructofuranosidase activity
SA27298_RS07545	COG1609	Transcriptional regulator
SA27298_RS07550	COG0561	phosphatase activity
SA27298_RS07555	COG4608	Belongs to the ABC transporter superfamily
SA27298_RS07560	COG0444	Belongs to the ABC transporter superfamily
SA27298_RS07565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SA27298_RS07570	COG0601	transmembrane transport
SA27298_RS07575	COG4166	transmembrane transport
SA27298_RS07580	COG4166	transmembrane transport
SA27298_RS07590	COG0504	CTP synthase activity
SA27298_RS07595	COG3343	RNA polymerase activity
SA27298_RS07600	COG0544	peptidyl-prolyl cis-trans isomerase activity
SA27298_RS07605	COG4475	Protein of unknown function (DUF436)
SA27298_RS07610	COG4720	Psort location CytoplasmicMembrane, score
SA27298_RS07615	COG0351	phosphomethylpyrimidine kinase
SA27298_RS07620	COG0101	tRNA pseudouridine synthase activity
SA27298_RS07630	COG0484	heat shock protein binding
SA27298_RS07640	COG0443	Heat shock 70 kDa protein
SA27298_RS07645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SA27298_RS07650	COG1420	regulation of RNA biosynthetic process
SA27298_RS07665	COG0588	phosphoglycerate mutase activity
SA27298_RS07670	COG0588	phosphoglycerate mutase activity
SA27298_RS07675	COG2848	UPF0210 protein
SA27298_RS07680	COG3830	Belongs to the UPF0237 family
SA27298_RS07700	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
SA27298_RS07705	COG1215	transferase activity, transferring glycosyl groups
SA27298_RS07715	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SA27298_RS07730	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SA27298_RS07735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SA27298_RS07755	COG3842	ATPase activity
SA27298_RS07765	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SA27298_RS07770	COG0215	cysteine-tRNA ligase activity
SA27298_RS07775	COG1045	serine acetyltransferase
SA27298_RS07780	COG1185	polyribonucleotide nucleotidyltransferase activity
SA27298_RS07785	COG1164	Oligoendopeptidase f
SA27298_RS07800	COG3118	belongs to the thioredoxin family
SA27298_RS07815	COG1187	pseudouridine synthase activity
SA27298_RS07850	COG2176	DNA-directed DNA polymerase activity
SA27298_RS07860	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SA27298_RS07865	COG1523	belongs to the glycosyl hydrolase 13 family
SA27298_RS07885	COG1609	Transcriptional regulator
SA27298_RS07890	COG0561	phosphatase activity
SA27298_RS07895	COG0495	leucyl-tRNA aminoacylation
SA27298_RS07905	COG3590	peptidase
SA27298_RS07930	COG1490	D-aminoacyl-tRNA deacylase activity
SA27298_RS07945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SA27298_RS07950	COG2264	protein methyltransferase activity
SA27298_RS07970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SA27298_RS07990	COG1418	mRNA catabolic process
SA27298_RS07995	COG1428	Deoxynucleoside kinase
SA27298_RS08010	COG0459	protein refolding
SA27298_RS08015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SA27298_RS08025	COG3716	PTS system mannose fructose sorbose family IID component
SA27298_RS08030	COG3715	PTS system
SA27298_RS08050	COG2197	response regulator
SA27298_RS08055	COG4585	Histidine kinase
SA27298_RS08070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SA27298_RS08075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SA27298_RS08085	COG1363	Peptidase, m42
SA27298_RS08095	COG0285	dihydrofolate synthase activity
SA27298_RS08105	COG0442	prolyl-tRNA aminoacylation
SA27298_RS08110	COG0750	zinc metalloprotease
SA27298_RS08115	COG4589	Belongs to the CDS family
SA27298_RS08120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SA27298_RS08130	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
SA27298_RS08135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SA27298_RS08155	COG3623	hexulose-6-phosphate isomerase
SA27298_RS08165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SA27298_RS08175	COG3037	sugar-specific permease SgaT UlaA
SA27298_RS08190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SA27298_RS08220	COG4537	Required for transformation and DNA binding
SA27298_RS08225	COG1459	type II secretion system
SA27298_RS08230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SA27298_RS08240	COG0174	glutamine synthetase
SA27298_RS08245	COG0789	Transcriptional regulator
SA27298_RS08255	COG0126	phosphoglycerate kinase activity
SA27298_RS08260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SA27298_RS08265	COG0085	RNA polymerase activity
SA27298_RS08275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SA27298_RS08280	COG0500	methyltransferase
SA27298_RS08290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SA27298_RS08295	COG1473	amidohydrolase
SA27298_RS08300	COG2171	N-acyltransferase activity
SA27298_RS08305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SA27298_RS08315	COG0756	dUTP diphosphatase activity
SA27298_RS08325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SA27298_RS08330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SA27298_RS08335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SA27298_RS08360	COG1214	PFAM Peptidase M22, glycoprotease
SA27298_RS08380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SA27298_RS08385	COG0049	tRNA binding
SA27298_RS08390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SA27298_RS08400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SA27298_RS08405	COG3481	metal-dependent phosphohydrolase, HD sub domain
SA27298_RS08415	COG1564	THIamine pyrophosphokinase
SA27298_RS08425	COG1162	GTPase activity
SA27298_RS08440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SA27298_RS08455	COG0084	hydrolase, TatD family'
SA27298_RS08460	COG0582	viral genome integration into host DNA
SA27298_RS08515	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SA27298_RS08535	COG0594	ribonuclease P activity
SA27298_RS08545	COG0166	Belongs to the GPI family
SA27298_RS08585	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SA27298_RS08605	COG2723	6-phospho-beta-galactosidase activity
SA27298_RS08610	COG1263	PTS System
SA27298_RS08610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA27298_RS08610	COG2190	(PTS) system
SA27298_RS08615	COG1263	PTS System
SA27298_RS08615	COG2190	(PTS) system
SA27298_RS08615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SA27298_RS08645	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SA27298_RS08650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SA27298_RS08665	COG4463	regulation of RNA biosynthetic process
SA27298_RS08685	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SA27298_RS08690	COG0052	Belongs to the universal ribosomal protein uS2 family
SA27298_RS08700	COG0203	ribosomal protein L17
SA27298_RS08705	COG0202	RNA polymerase activity
SA27298_RS08710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SA27298_RS08715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SA27298_RS08720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SA27298_RS08725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SA27298_RS08730	COG0563	adenylate kinase activity
SA27298_RS08735	COG0201	protein transport
SA27298_RS08740	COG0200	Binds to the 23S rRNA
SA27298_RS08745	COG1841	ribosomal large subunit assembly
SA27298_RS08750	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SA27298_RS08760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SA27298_RS08765	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SA27298_RS08770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SA27298_RS08775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SA27298_RS08780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SA27298_RS08785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SA27298_RS08795	COG0255	Belongs to the universal ribosomal protein uL29 family
SA27298_RS08800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SA27298_RS08805	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SA27298_RS08810	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SA27298_RS08820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SA27298_RS08825	COG0089	rRNA binding
SA27298_RS08830	COG0088	Forms part of the polypeptide exit tunnel
SA27298_RS08835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SA27298_RS08840	COG0051	transcription antitermination factor activity, RNA binding
SA27298_RS08855	COG0343	queuine tRNA-ribosyltransferase activity
SA27298_RS08870	COG1832	CoA-binding protein
SA27298_RS08875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SA27298_RS08875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SA27298_RS08880	COG5002	protein histidine kinase activity
SA27298_RS08900	COG0562	UDP-galactopyranose mutase
SA27298_RS08915	COG0438	transferase activity, transferring glycosyl groups
SA27298_RS08925	COG1442	glycosyl transferase family 8
SA27298_RS08925	COG1216	Glycosyl transferase, family 2
SA27298_RS08930	COG1045	serine acetyltransferase
SA27298_RS08935	COG0438	transferase activity, transferring glycosyl groups
SA27298_RS08955	COG3944	biosynthesis protein
SA27298_RS08960	COG4464	protein tyrosine phosphatase activity
SA27298_RS08970	COG0602	queuosine metabolic process
SA27298_RS09000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SA27298_RS09010	COG0285	dihydrofolate synthase activity
SA27298_RS09015	COG3906	Belongs to the UPF0473 family
SA27298_RS09020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SA27298_RS09025	COG4472	Bacterial protein of unknown function (DUF965)
SA27298_RS09040	COG1393	Belongs to the ArsC family
SA27298_RS09045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SA27298_RS09050	COG1058	Belongs to the CinA family
SA27298_RS09050	COG1546	Belongs to the CinA family
SA27298_RS09060	COG0519	Catalyzes the synthesis of GMP from XMP
SA27298_RS09065	COG0632	four-way junction helicase activity
SA27298_RS09075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SA27298_RS09090	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SA27298_RS09095	COG1438	arginine binding
SA27298_RS09100	COG0018	arginyl-trna synthetase
SA27298_RS09105	COG1780	Probably involved in ribonucleotide reductase function
SA27298_RS09115	COG0058	SHG alpha-glucan phosphorylase activity
SA27298_RS09120	COG1640	4-alpha-glucanotransferase
SA27298_RS09125	COG2182	Extracellular solute-binding protein
SA27298_RS09130	COG1175	transmembrane transport
SA27298_RS09135	COG3833	ABC-type maltose transport systems, permease component
SA27298_RS09140	COG5521	maltodextrose utilization protein MalA
SA27298_RS09145	COG1609	Transcriptional regulator
SA27298_RS09150	COG1523	belongs to the glycosyl hydrolase 13 family
SA27298_RS09155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SA27298_RS09175	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SA27298_RS09180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SA27298_RS09235	COG4974	Belongs to the 'phage' integrase family
SA27298_RS09290	COG0582	viral genome integration into host DNA
SA27298_RS09315	COG2807	transmembrane transport
SA27298_RS09320	COG2094	Belongs to the DNA glycosylase MPG family
SA27298_RS09325	COG0561	phosphatase activity
SA27298_RS09330	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SA27298_RS09335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SA27298_RS09340	COG1696	Membrane protein involved in D-alanine export
SA27298_RS09430	COG1011	Hydrolase
SA27298_RS09440	COG0305	Participates in initiation and elongation during chromosome replication
SA27298_RS09455	COG0445	tRNA wobble uridine modification
SA27298_RS09460	COG0482	sulfurtransferase activity
SA27298_RS09470	COG1760	l-serine dehydratase
SA27298_RS09475	COG1760	l-serine dehydratase
SA27298_RS09490	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SA27298_RS09495	COG1122	ATPase activity
SA27298_RS09500	COG1122	ATPase activity
SA27298_RS09505	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SA27298_RS09515	COG0612	Peptidase, M16
SA27298_RS09520	COG0612	Peptidase, M16
SA27298_RS09530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SA27298_RS09535	COG0516	GMP reductase activity
SA27298_RS09535	COG0517	IMP dehydrogenase activity
SA27298_RS09540	COG0180	Tryptophanyl-tRNA synthetase
SA27298_RS09545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SA27298_RS09550	COG0149	triose-phosphate isomerase activity
SA27298_RS09560	COG0488	(ABC) transporter
SA27298_RS09600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SA27298_RS09605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SA27298_RS09610	COG1475	DNA binding