locus-tag	class	description
I6J12_RS00030	COG4537	Required for transformation and DNA binding
I6J12_RS00060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6J12_RS00075	COG3037	sugar-specific permease SgaT UlaA
I6J12_RS00085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J12_RS00095	COG3623	hexulose-6-phosphate isomerase
I6J12_RS00115	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6J12_RS00120	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
I6J12_RS00130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J12_RS00135	COG4589	Belongs to the CDS family
I6J12_RS00140	COG0750	zinc metalloprotease
I6J12_RS00145	COG0442	prolyl-tRNA aminoacylation
I6J12_RS00155	COG0285	dihydrofolate synthase activity
I6J12_RS00165	COG1363	Peptidase, m42
I6J12_RS00175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J12_RS00180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J12_RS00195	COG4585	Histidine kinase
I6J12_RS00200	COG2197	response regulator
I6J12_RS00220	COG3715	PTS system
I6J12_RS00225	COG3716	PTS system mannose fructose sorbose family IID component
I6J12_RS00235	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6J12_RS00240	COG0459	protein refolding
I6J12_RS00255	COG1428	Deoxynucleoside kinase
I6J12_RS00260	COG1418	mRNA catabolic process
I6J12_RS00275	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J12_RS00285	COG1051	belongs to the nudix hydrolase family
I6J12_RS00295	COG2264	protein methyltransferase activity
I6J12_RS00300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J12_RS00315	COG1490	D-aminoacyl-tRNA deacylase activity
I6J12_RS00340	COG3590	peptidase
I6J12_RS00385	COG0527	aspartate kinase activity
I6J12_RS00390	COG1024	Enoyl-CoA hydratase
I6J12_RS00400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J12_RS00410	COG2070	2-Nitropropane dioxygenase
I6J12_RS00415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J12_RS00425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J12_RS00435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6J12_RS00440	COG0439	Biotin carboxylase
I6J12_RS00445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6J12_RS00450	COG0825	malonyl-CoA metabolic process
I6J12_RS00455	COG0586	Pfam SNARE associated Golgi protein
I6J12_RS00470	COG3716	PTS system mannose fructose sorbose family IID component
I6J12_RS00475	COG3715	PTS system
I6J12_RS00485	COG1064	alcohol dehydrogenase
I6J12_RS00490	COG0561	phosphatase activity
I6J12_RS00500	COG2252	PERMEase
I6J12_RS00505	COG0802	atpase or kinase
I6J12_RS00515	COG1316	TRANSCRIPTIONal
I6J12_RS00525	COG0537	adenosine 5'-monophosphoramidase activity
I6J12_RS00530	COG1131	(ABC) transporter
I6J12_RS00540	COG0510	thiamine kinase activity
I6J12_RS00545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J12_RS00555	COG0779	Required for maturation of 30S ribosomal subunits
I6J12_RS00560	COG0195	Participates in both transcription termination and antitermination
I6J12_RS00565	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6J12_RS00580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J12_RS00585	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J12_RS00600	COG0752	glycyl-tRNA synthetase alpha subunit
I6J12_RS00605	COG0751	glycine-tRNA ligase activity
I6J12_RS00620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J12_RS00640	COG0768	penicillin binding
I6J12_RS00645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J12_RS00650	COG4166	transmembrane transport
I6J12_RS00660	COG0191	fructose-bisphosphate aldolase activity
I6J12_RS00685	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J12_RS00695	COG1461	Dihydroxyacetone kinase
I6J12_RS00705	COG1131	(ABC) transporter
I6J12_RS00720	COG4585	Histidine kinase
I6J12_RS00760	COG1131	(ABC) transporter
I6J12_RS00785	COG1126	abc transporter atp-binding protein
I6J12_RS00790	COG0765	amino acid transport
I6J12_RS00800	COG1968	undecaprenyl-diphosphatase activity
I6J12_RS00805	COG4862	establishment of competence for transformation
I6J12_RS00810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J12_RS00820	COG0719	Fe-S assembly protein
I6J12_RS00825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J12_RS00835	COG1686	Belongs to the peptidase S11 family
I6J12_RS00840	COG0513	Belongs to the DEAD box helicase family
I6J12_RS00850	COG1126	abc transporter atp-binding protein
I6J12_RS00860	COG0492	ferredoxin-NADP+ reductase activity
I6J12_RS00865	COG1113	amino acid transport
I6J12_RS00870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J12_RS00875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6J12_RS00880	COG3579	cysteine-type endopeptidase activity
I6J12_RS00885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J12_RS00890	COG3331	DNA recombination
I6J12_RS00895	COG4474	Belongs to the UPF0398 family
I6J12_RS00900	COG3599	regulation of cell shape
I6J12_RS00910	COG0116	Belongs to the methyltransferase superfamily
I6J12_RS00920	COG0450	alkyl hydroperoxide reductase
I6J12_RS00925	COG3634	alkyl hydroperoxide reductase activity
I6J12_RS00935	COG1418	mRNA catabolic process
I6J12_RS00940	COG0194	GDP metabolic process
I6J12_RS00945	COG1758	RNA polymerase activity
I6J12_RS00950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J12_RS00955	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6J12_RS00960	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J12_RS00960	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J12_RS00965	COG0631	protein serine/threonine phosphatase activity
I6J12_RS00970	COG2815	serine threonine protein kinase
I6J12_RS00970	COG0515	serine threonine protein kinase
I6J12_RS00980	COG4585	Histidine kinase
I6J12_RS00995	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J12_RS01005	COG3557	Belongs to the UPF0374 family
I6J12_RS01010	COG2137	regulation of response to DNA damage stimulus
I6J12_RS01015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J12_RS01025	COG2070	2-Nitropropane dioxygenase
I6J12_RS01045	COG0519	Catalyzes the synthesis of GMP from XMP
I6J12_RS01055	COG0525	valine-tRNA ligase activity
I6J12_RS01095	COG1739	Uncharacterized protein family UPF0029
I6J12_RS01100	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6J12_RS01105	COG1040	competence protein
I6J12_RS01115	COG0742	ribosomal rna small subunit methyltransferase
I6J12_RS01120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J12_RS01125	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J12_RS01130	COG4470	Protein conserved in bacteria
I6J12_RS01135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J12_RS01175	COG1187	pseudouridine synthase activity
I6J12_RS01180	COG1217	gtp-binding protein TYPA
I6J12_RS01190	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6J12_RS01195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6J12_RS01200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6J12_RS01210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6J12_RS01215	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J12_RS01220	COG1799	cell septum assembly
I6J12_RS01235	COG3599	regulation of cell shape
I6J12_RS01240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6J12_RS01245	COG1846	Transcriptional regulator
I6J12_RS01255	COG0628	permease
I6J12_RS01265	COG1253	flavin adenine dinucleotide binding
I6J12_RS01270	COG2188	Transcriptional regulator
I6J12_RS01275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J12_RS01275	COG1263	PTS System
I6J12_RS01280	COG0366	Alpha amylase catalytic
I6J12_RS01290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J12_RS01315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6J12_RS01320	COG2244	polysaccharide biosynthetic process
I6J12_RS01325	COG0626	cystathionine gamma-synthase activity
I6J12_RS01330	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J12_RS01335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J12_RS01340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6J12_RS01345	COG0740	serine-type endopeptidase activity
I6J12_RS01370	COG4177	L-phenylalanine transmembrane transporter activity
I6J12_RS01385	COG0517	IMP dehydrogenase activity
I6J12_RS01390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J12_RS01400	COG0470	DNA polymerase III
I6J12_RS01405	COG4467	Involved in initiation control of chromosome replication
I6J12_RS01415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6J12_RS01420	COG1393	Belongs to the ArsC family
I6J12_RS01425	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J12_RS01430	COG0708	Exodeoxyribonuclease III
I6J12_RS01450	COG0640	Transcriptional regulator
I6J12_RS01475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J12_RS01475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J12_RS01485	COG0745	RESPONSE REGULATOR receiver
I6J12_RS01490	COG0642	Histidine kinase
I6J12_RS01500	COG1136	(ABC) transporter
I6J12_RS01505	COG0577	efflux transmembrane transporter activity
I6J12_RS01510	COG0531	amino acid
I6J12_RS01520	COG0456	acetyltransferase
I6J12_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
I6J12_RS01560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J12_RS01575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J12_RS01585	COG0488	(ABC) transporter
I6J12_RS01590	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J12_RS01600	COG1983	PspC domain protein
I6J12_RS01605	COG1674	ftsk spoiiie
I6J12_RS01605	COG0697	spore germination
I6J12_RS01610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J12_RS01625	COG0081	regulation of translation
I6J12_RS01630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J12_RS01635	COG0372	Belongs to the citrate synthase family
I6J12_RS01640	COG0538	isocitrate dehydrogenase activity
I6J12_RS01645	COG0528	UMP kinase activity
I6J12_RS01650	COG0233	cytoplasmic translational termination
I6J12_RS01655	COG2996	Protein conserved in bacteria
I6J12_RS01665	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J12_RS01685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J12_RS01695	COG3290	protein histidine kinase activity
I6J12_RS01775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J12_RS01780	COG0549	Belongs to the carbamate kinase family
I6J12_RS01785	COG1288	antiporter activity
I6J12_RS01790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J12_RS01805	COG1438	arginine binding
I6J12_RS01810	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J12_RS01815	COG0363	glucosamine-6-phosphate deaminase activity
I6J12_RS01830	COG2723	6-phospho-beta-galactosidase activity
I6J12_RS01840	COG4095	Psort location CytoplasmicMembrane, score
I6J12_RS01850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J12_RS01850	COG3711	transcriptional antiterminator
I6J12_RS01855	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J12_RS01865	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J12_RS01880	COG4122	O-methyltransferase activity
I6J12_RS01885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6J12_RS01895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J12_RS01900	COG1132	(ABC) transporter
I6J12_RS01910	COG2348	transferase activity, transferring amino-acyl groups
I6J12_RS01920	COG1078	dGTPase activity
I6J12_RS01960	COG2884	Cell division ATP-binding protein ftsE
I6J12_RS01965	COG2177	Part of the ABC transporter FtsEX involved in
I6J12_RS01975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J12_RS01975	COG1199	ATP-dependent helicase activity
I6J12_RS01985	COG0772	Belongs to the SEDS family
I6J12_RS02000	COG0187	DNA topoisomerase II activity
I6J12_RS02005	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6J12_RS02010	COG2706	6-phosphogluconolactonase activity
I6J12_RS02015	COG0745	RESPONSE REGULATOR receiver
I6J12_RS02020	COG5002	protein histidine kinase activity
I6J12_RS02020	COG3850	Histidine kinase
I6J12_RS02025	COG0628	permease
I6J12_RS02035	COG0028	Belongs to the TPP enzyme family
I6J12_RS02040	COG3527	Alpha-acetolactate decarboxylase
I6J12_RS02045	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6J12_RS02060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J12_RS02070	COG4443	Transcriptional Coactivator p15 (PC4)
I6J12_RS02075	COG4152	abc transporter atp-binding protein
I6J12_RS02080	COG1668	transmembrane transport
I6J12_RS02085	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6J12_RS02090	COG1074	ATP-dependent DNA helicase activity
I6J12_RS02095	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J12_RS02100	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6J12_RS02105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6J12_RS02110	COG0297	glycogen (starch) synthase activity
I6J12_RS02115	COG0058	SHG alpha-glucan phosphorylase activity
I6J12_RS02125	COG0356	it plays a direct role in the translocation of protons across the membrane
I6J12_RS02130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6J12_RS02135	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J12_RS02140	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6J12_RS02145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6J12_RS02165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J12_RS02185	COG1132	(ABC) transporter
I6J12_RS02210	COG1346	cytolysis
I6J12_RS02215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J12_RS02220	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6J12_RS02230	COG2384	SAM-dependent methyltransferase
I6J12_RS02235	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6J12_RS02240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J12_RS02255	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J12_RS02265	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J12_RS02270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J12_RS02280	COG0463	Glycosyl transferase, family 2
I6J12_RS02305	COG0463	Glycosyl transferase, family 2
I6J12_RS02310	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6J12_RS02360	COG1368	sulfuric ester hydrolase activity
I6J12_RS02365	COG0006	proline dipeptidase activity
I6J12_RS02370	COG1609	Transcriptional regulator
I6J12_RS02380	COG0438	transferase activity, transferring glycosyl groups
I6J12_RS02390	COG0745	RESPONSE REGULATOR receiver
I6J12_RS02395	COG5002	protein histidine kinase activity
I6J12_RS02400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J12_RS02410	COG0571	ribonuclease III activity
I6J12_RS02415	COG1196	nuclear chromosome segregation
I6J12_RS02420	COG0561	phosphatase activity
I6J12_RS02425	COG0561	phosphatase activity
I6J12_RS02430	COG0552	protein localization to endoplasmic reticulum
I6J12_RS02435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6J12_RS02440	COG0477	Major facilitator Superfamily
I6J12_RS02445	COG3689	TIGRFAM TIGR03943 family protein
I6J12_RS02450	COG0701	Predicted permease
I6J12_RS02480	COG2183	response to ionizing radiation
I6J12_RS02485	COG3091	SprT-like family
I6J12_RS02500	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6J12_RS02505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6J12_RS02530	COG0826	peptidase U32
I6J12_RS02555	COG0488	(ABC) transporter
I6J12_RS02565	COG3442	glutamine amidotransferase
I6J12_RS02570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J12_RS02575	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J12_RS02585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J12_RS02590	COG0560	Phosphoserine phosphatase
I6J12_RS02615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6J12_RS02625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J12_RS02640	COG0726	polysaccharide deacetylase
I6J12_RS02650	COG0673	inositol 2-dehydrogenase activity
I6J12_RS02655	COG0572	uridine kinase
I6J12_RS02665	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J12_RS02670	COG0561	phosphatase activity
I6J12_RS02675	COG0481	GTPase activity
I6J12_RS02685	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J12_RS02690	COG3842	ATPase activity
I6J12_RS02695	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J12_RS02700	COG1177	transmembrane transport
I6J12_RS02715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J12_RS02715	COG0574	Belongs to the PEP-utilizing enzyme family
I6J12_RS02720	COG0517	IMP dehydrogenase activity
I6J12_RS02725	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6J12_RS02730	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6J12_RS02735	COG1104	cysteine desulfurase activity
I6J12_RS02740	COG0301	tRNA thio-modification
I6J12_RS02745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6J12_RS02755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J12_RS02760	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J12_RS02775	COG1937	Protein conserved in bacteria
I6J12_RS02785	COG0583	DNA-binding transcription factor activity
I6J12_RS02795	COG0564	pseudouridine synthase activity
I6J12_RS02800	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J12_RS02810	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J12_RS02830	COG0038	chloride channel
I6J12_RS02835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J12_RS02840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J12_RS02855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6J12_RS02860	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J12_RS02860	COG1388	LysM domain
I6J12_RS02870	COG1674	ftsk spoiiie
I6J12_RS02920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J12_RS02925	COG0492	ferredoxin-NADP+ reductase activity
I6J12_RS02935	COG1349	DNA-binding transcription factor activity
I6J12_RS02940	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J12_RS02945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J12_RS02945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J12_RS02945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J12_RS02955	COG1307	EDD domain protein, DegV family
I6J12_RS02960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6J12_RS02965	COG0617	tRNA 3'-terminal CCA addition
I6J12_RS02970	COG0488	(ABC) transporter
I6J12_RS02985	COG0072	phenylalanine-tRNA ligase activity
I6J12_RS02985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J12_RS03005	COG1011	Hydrolase
I6J12_RS03020	COG1268	BioY protein
I6J12_RS03025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J12_RS03035	COG1136	(ABC) transporter
I6J12_RS03040	COG0577	efflux transmembrane transporter activity
I6J12_RS03050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6J12_RS03055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J12_RS03075	COG0300	oxidoreductase activity
I6J12_RS03090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J12_RS03090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J12_RS03100	COG1131	(ABC) transporter
I6J12_RS03105	COG1725	Transcriptional regulator
I6J12_RS03115	COG0205	6-phosphofructokinase activity
I6J12_RS03120	COG0469	pyruvate kinase activity
I6J12_RS03130	COG0765	amino acid transport
I6J12_RS03140	COG1192	Involved in chromosome partitioning
I6J12_RS03210	COG3103	Sh3 type 3 domain protein
I6J12_RS03210	COG0791	NLP P60 protein
I6J12_RS03210	COG1388	LysM domain
I6J12_RS03240	COG0551	DNA topoisomerase type I activity
I6J12_RS03240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J12_RS03295	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J12_RS03300	COG3433	isochorismatase activity
I6J12_RS03300	COG2226	methyltransferase
I6J12_RS03300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J12_RS03315	COG1309	transcriptional regulator
I6J12_RS03330	COG1129	ABC transporter
I6J12_RS03335	COG1132	(ABC) transporter
I6J12_RS03335	COG2375	cellular response to nickel ion
I6J12_RS03340	COG1132	(ABC) transporter
I6J12_RS03380	COG1126	abc transporter atp-binding protein
I6J12_RS03390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6J12_RS03395	COG0210	DNA helicase
I6J12_RS03405	COG2378	regulation of single-species biofilm formation
I6J12_RS03410	COG1132	(ABC) transporter
I6J12_RS03410	COG2375	cellular response to nickel ion
I6J12_RS03415	COG1132	(ABC) transporter
I6J12_RS03430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J12_RS03435	COG0196	riboflavin kinase activity
I6J12_RS03440	COG1393	Belongs to the ArsC family
I6J12_RS03445	COG4476	Belongs to the UPF0223 family
I6J12_RS03450	COG0483	inositol monophosphate 1-phosphatase activity
I6J12_RS03455	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J12_RS03455	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6J12_RS03465	COG0573	inorganic phosphate transmembrane transporter activity
I6J12_RS03470	COG0581	inorganic phosphate transmembrane transporter activity
I6J12_RS03475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J12_RS03480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J12_RS03485	COG0704	Plays a role in the regulation of phosphate uptake
I6J12_RS03490	COG2003	Belongs to the UPF0758 family
I6J12_RS03510	COG1104	cysteine desulfurase activity
I6J12_RS03515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J12_RS03525	COG2357	RelA SpoT domain protein
I6J12_RS03535	COG0564	pseudouridine synthase activity
I6J12_RS03540	COG0280	phosphate acetyltransferase
I6J12_RS03585	COG1132	(ABC) transporter
I6J12_RS03590	COG0488	(ABC) transporter
I6J12_RS03610	COG0556	nucleotide-excision repair
I6J12_RS03620	COG1131	(ABC) transporter
I6J12_RS03630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J12_RS03640	COG0647	UMP catabolic process
I6J12_RS03660	COG1660	Displays ATPase and GTPase activities
I6J12_RS03665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6J12_RS03670	COG1481	regulation of sporulation
I6J12_RS03680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6J12_RS03690	COG0540	Belongs to the ATCase OTCase family
I6J12_RS03695	COG0505	Belongs to the CarA family
I6J12_RS03700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6J12_RS03705	COG2814	Major facilitator Superfamily
I6J12_RS03710	COG0583	DNA-binding transcription factor activity
I6J12_RS03735	COG0543	2 iron, 2 sulfur cluster binding
I6J12_RS03740	COG0167	dihydroorotate dehydrogenase activity
I6J12_RS03745	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J12_RS03755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6J12_RS03770	COG4479	Belongs to the UPF0346 family
I6J12_RS03775	COG1702	phosphate starvation-inducible protein PhoH
I6J12_RS03795	COG0686	Belongs to the AlaDH PNT family
I6J12_RS03805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J12_RS03820	COG1132	(ABC) transporter
I6J12_RS03825	COG1132	(ABC) transporter
I6J12_RS03830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J12_RS03835	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6J12_RS03840	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6J12_RS03865	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J12_RS03870	COG0237	dephospho-CoA kinase activity
I6J12_RS03885	COG2814	Major facilitator Superfamily
I6J12_RS03890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J12_RS03900	COG0557	exoribonuclease II activity
I6J12_RS03905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J12_RS03915	COG2333	competence protein COMEC
I6J12_RS03915	COG0658	competence protein
I6J12_RS03930	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6J12_RS03935	COG1051	belongs to the nudix hydrolase family
I6J12_RS03940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6J12_RS03945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J12_RS03950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J12_RS03960	COG4109	DRTGG domain
I6J12_RS03965	COG0024	Methionine aminopeptidase
I6J12_RS03975	COG1846	Transcriptional regulator
I6J12_RS03985	COG2246	polysaccharide biosynthetic process
I6J12_RS03990	COG4708	membrane
I6J12_RS04000	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6J12_RS04005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J12_RS04010	COG1597	lipid kinase activity
I6J12_RS04015	COG1523	belongs to the glycosyl hydrolase 13 family
I6J12_RS04020	COG0228	four-way junction DNA binding
I6J12_RS04025	COG1837	Belongs to the UPF0109 family
I6J12_RS04030	COG1827	regulation of RNA biosynthetic process
I6J12_RS04045	COG3142	Participates in the control of copper homeostasis
I6J12_RS04050	COG2315	Protein conserved in bacteria
I6J12_RS04055	COG1132	(ABC) transporter
I6J12_RS04060	COG1132	(ABC) transporter
I6J12_RS04065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J12_RS04080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6J12_RS04085	COG1970	mechanosensitive ion channel activity
I6J12_RS04090	COG0358	DNA primase activity
I6J12_RS04095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J12_RS04100	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J12_RS04105	COG1114	Component of the transport system for branched-chain amino acids
I6J12_RS04110	COG0785	Cytochrome C biogenesis protein
I6J12_RS04115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J12_RS04120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J12_RS04120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J12_RS04130	COG2972	Histidine kinase
I6J12_RS04145	COG4555	ABC transporter
I6J12_RS04150	COG0431	NADPH-dependent FMN reductase
I6J12_RS04150	COG1053	succinate dehydrogenase
I6J12_RS04150	COG3976	FMN-binding domain protein
I6J12_RS04180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J12_RS04190	COG1942	4-Oxalocrotonate Tautomerase
I6J12_RS04195	COG1435	thymidine kinase activity
I6J12_RS04200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J12_RS04205	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J12_RS04215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J12_RS04225	COG0741	lytic transglycosylase activity
I6J12_RS04310	COG2188	Transcriptional regulator
I6J12_RS04320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J12_RS04325	COG1136	(ABC) transporter
I6J12_RS04325	COG0577	efflux transmembrane transporter activity
I6J12_RS04330	COG4974	Belongs to the 'phage' integrase family
I6J12_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
I6J12_RS04340	COG0095	Lipoate-protein ligase
I6J12_RS04345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J12_RS04350	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J12_RS04355	COG0022	dehydrogenase e1 component
I6J12_RS04360	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J12_RS04380	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6J12_RS04390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J12_RS04395	COG0758	DNA mediated transformation
I6J12_RS04410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J12_RS04415	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J12_RS04420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6J12_RS04425	COG1960	acyl-CoA dehydrogenase activity
I6J12_RS04430	COG0583	DNA-binding transcription factor activity
I6J12_RS04435	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6J12_RS04445	COG1024	Enoyl-CoA hydratase
I6J12_RS04455	COG0183	Belongs to the thiolase family
I6J12_RS04465	COG1960	acyl-CoA dehydrogenase activity
I6J12_RS04470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J12_RS04475	COG3764	Sortase (surface protein transpeptidase)
I6J12_RS04480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J12_RS04485	COG0039	L-malate dehydrogenase activity
I6J12_RS04500	COG0539	negative regulation of cytoplasmic translation
I6J12_RS04520	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J12_RS04525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J12_RS04550	COG0187	DNA topoisomerase II activity
I6J12_RS04555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6J12_RS04560	COG0737	Belongs to the 5'-nucleotidase family
I6J12_RS04565	COG2976	Protein conserved in bacteria
I6J12_RS04570	COG2131	deaminase
I6J12_RS04575	COG1309	transcriptional regulator
I6J12_RS04620	COG2814	Major facilitator Superfamily
I6J12_RS04625	COG0017	Asparaginyl-tRNA synthetase
I6J12_RS04635	COG0436	Aminotransferase
I6J12_RS04645	COG1846	Transcriptional regulator
I6J12_RS04650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J12_RS04655	COG3022	response to hydroperoxide
I6J12_RS04665	COG1272	protein, Hemolysin III
I6J12_RS04670	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J12_RS04675	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J12_RS04680	COG3845	ABC transporter
I6J12_RS04685	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J12_RS04690	COG0295	cytidine deaminase activity
I6J12_RS04695	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6J12_RS04705	COG2813	Specifically methylates the guanine in position
I6J12_RS04710	COG1072	(Pantothenic acid kinase))
I6J12_RS04715	COG0268	Binds directly to 16S ribosomal RNA
I6J12_RS04725	COG4187	Peptidase family M20/M25/M40
I6J12_RS04735	COG5002	protein histidine kinase activity
I6J12_RS04740	COG0745	RESPONSE REGULATOR receiver
I6J12_RS04765	COG1940	carbohydrate kinase activity
I6J12_RS04795	COG2184	nucleotidyltransferase activity
I6J12_RS04840	COG0083	homoserine kinase activity
I6J12_RS04850	COG0726	polysaccharide deacetylase
I6J12_RS04860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J12_RS04875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J12_RS04880	COG1609	Transcriptional regulator
I6J12_RS04885	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6J12_RS04885	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6J12_RS04900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J12_RS04905	COG1956	GAF domain-containing protein
I6J12_RS04920	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J12_RS04920	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6J12_RS04925	COG0336	Belongs to the RNA methyltransferase TrmD family
I6J12_RS04930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J12_RS04945	COG4974	Belongs to the 'phage' integrase family
I6J12_RS04980	COG1937	Protein conserved in bacteria
I6J12_RS04995	COG3843	relaxase mobilization nuclease domain protein
I6J12_RS05030	COG0542	response to heat
I6J12_RS05035	COG1396	sequence-specific DNA binding
I6J12_RS05100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6J12_RS05125	COG1132	(ABC) transporter
I6J12_RS05130	COG2375	cellular response to nickel ion
I6J12_RS05130	COG1132	(ABC) transporter
I6J12_RS05140	COG0601	transmembrane transport
I6J12_RS05145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J12_RS05150	COG0444	Belongs to the ABC transporter superfamily
I6J12_RS05160	COG0747	negative chemotaxis
I6J12_RS05230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J12_RS05230	COG0551	DNA topoisomerase type I activity
I6J12_RS05415	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6J12_RS05425	COG0222	ribosome binding
I6J12_RS05430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J12_RS05440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J12_RS05445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J12_RS05460	COG1247	-acetyltransferase
I6J12_RS05465	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6J12_RS05475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J12_RS05480	COG4684	Psort location CytoplasmicMembrane, score
I6J12_RS05485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J12_RS05500	COG0582	viral genome integration into host DNA
I6J12_RS05540	COG1388	LysM domain
I6J12_RS05660	COG0740	serine-type endopeptidase activity
I6J12_RS05720	COG1132	(ABC) transporter
I6J12_RS05720	COG2375	cellular response to nickel ion
I6J12_RS05725	COG1129	ABC transporter
I6J12_RS05760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J12_RS05760	COG2226	methyltransferase
I6J12_RS05760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6J12_RS05760	COG3433	isochorismatase activity
I6J12_RS05760	COG2226	methyltransferase
I6J12_RS05760	COG3433	isochorismatase activity
I6J12_RS05765	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6J12_RS05780	COG1321	iron dependent repressor
I6J12_RS05825	COG0551	DNA topoisomerase type I activity
I6J12_RS05825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J12_RS05845	COG1388	LysM domain
I6J12_RS05845	COG3103	Sh3 type 3 domain protein
I6J12_RS05845	COG0791	NLP P60 protein
I6J12_RS05915	COG1475	DNA binding
I6J12_RS05920	COG1192	Involved in chromosome partitioning
I6J12_RS05945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J12_RS05955	COG0077	Prephenate dehydratase
I6J12_RS05960	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J12_RS05965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J12_RS05975	COG3679	Belongs to the UPF0342 family
I6J12_RS05980	COG0287	Prephenate dehydrogenase
I6J12_RS05990	COG0730	response to heat
I6J12_RS05995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6J12_RS06000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J12_RS06005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J12_RS06010	COG0710	3-dehydroquinate dehydratase activity
I6J12_RS06015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J12_RS06020	COG1368	sulfuric ester hydrolase activity
I6J12_RS06030	COG0813	purine-nucleoside phosphorylase activity
I6J12_RS06040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6J12_RS06045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6J12_RS06060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J12_RS06070	COG1595	DNA-templated transcription, initiation
I6J12_RS06075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6J12_RS06080	COG0772	Belongs to the SEDS family
I6J12_RS06095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J12_RS06100	COG0406	alpha-ribazole phosphatase activity
I6J12_RS06105	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6J12_RS06145	COG1882	Formate acetyltransferase
I6J12_RS06150	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J12_RS06160	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J12_RS06170	COG1349	DNA-binding transcription factor activity
I6J12_RS06175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J12_RS06180	COG1959	2 iron, 2 sulfur cluster binding
I6J12_RS06200	COG1309	transcriptional regulator
I6J12_RS06220	COG0716	FMN binding
I6J12_RS06225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J12_RS06230	COG0254	rRNA binding
I6J12_RS06235	COG4974	Belongs to the 'phage' integrase family
I6J12_RS06295	COG1125	glycine betaine transport
I6J12_RS06300	COG1174	glycine betaine transport
I6J12_RS06310	COG1573	uracil-dna glycosylase
I6J12_RS06320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J12_RS06350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J12_RS06360	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J12_RS06370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J12_RS06385	COG1476	TRANSCRIPTIONal
I6J12_RS06400	COG0204	Acyl-transferase
I6J12_RS06405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J12_RS06410	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6J12_RS06415	COG2827	Endonuclease containing a URI domain
I6J12_RS06420	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6J12_RS06425	COG2723	6-phospho-beta-galactosidase activity
I6J12_RS06430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J12_RS06430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J12_RS06435	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J12_RS06440	COG3711	transcriptional antiterminator
I6J12_RS06455	COG3775	system Galactitol-specific IIC component
I6J12_RS06475	COG0698	ribose 5-phosphate isomerase
I6J12_RS06480	COG1349	DNA-binding transcription factor activity
I6J12_RS06490	COG0513	Belongs to the DEAD box helicase family
I6J12_RS06510	COG3620	sequence-specific DNA binding
I6J12_RS06530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J12_RS06535	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J12_RS06540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J12_RS06545	COG0768	penicillin binding
I6J12_RS06550	COG0588	phosphoglycerate mutase activity
I6J12_RS06565	COG1307	EDD domain protein, DegV family
I6J12_RS06570	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J12_RS06575	COG4605	iron ion homeostasis
I6J12_RS06580	COG4604	ABC transporter, ATP-binding protein
I6J12_RS06585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J12_RS06590	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6J12_RS06595	COG0497	DNA recombination
I6J12_RS06600	COG1438	arginine binding
I6J12_RS06605	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6J12_RS06615	COG1722	exodeoxyribonuclease VII activity
I6J12_RS06620	COG1570	exodeoxyribonuclease VII activity
I6J12_RS06630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J12_RS06635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6J12_RS06640	COG0577	efflux transmembrane transporter activity
I6J12_RS06645	COG1136	(ABC) transporter
I6J12_RS06685	COG4703	Protein of unknown function (DUF1797)
I6J12_RS06690	COG0542	response to heat
I6J12_RS06705	COG0494	nUDIX hydrolase
I6J12_RS06715	COG0025	NhaP-type Na H and K H
I6J12_RS06725	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J12_RS06730	COG1242	4 iron, 4 sulfur cluster binding
I6J12_RS06740	COG0671	phosphoesterase, PA-phosphatase related
I6J12_RS06745	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6J12_RS06755	COG0569	domain protein
I6J12_RS06775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J12_RS06780	COG1187	pseudouridine synthase activity
I6J12_RS06785	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6J12_RS06790	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6J12_RS06795	COG4974	Belongs to the 'phage' integrase family
I6J12_RS06810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6J12_RS06815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J12_RS06840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J12_RS06845	COG1254	Belongs to the acylphosphatase family
I6J12_RS06875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J12_RS06890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J12_RS06900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J12_RS06910	COG1160	GTP binding
I6J12_RS06920	COG1484	DNA-dependent DNA replication
I6J12_RS06930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J12_RS06945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J12_RS06945	COG1263	PTS System
I6J12_RS06945	COG2190	(PTS) system
I6J12_RS06950	COG0745	RESPONSE REGULATOR receiver
I6J12_RS06955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6J12_RS06970	COG0501	Belongs to the peptidase M48B family
I6J12_RS06975	COG1704	LemA family
I6J12_RS06980	COG0357	Ribosomal RNA small subunit methyltransferase G
I6J12_RS06985	COG1442	glycosyl transferase family 8
I6J12_RS06990	COG4221	oxidoreductase activity
I6J12_RS07000	COG1122	ATPase activity
I6J12_RS07030	COG4720	Psort location CytoplasmicMembrane, score
I6J12_RS07115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J12_RS07120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J12_RS07125	COG1464	Belongs to the NlpA lipoprotein family
I6J12_RS07130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J12_RS07145	COG1396	sequence-specific DNA binding
I6J12_RS07150	COG0217	transcriptional regulatory protein
I6J12_RS07155	COG1323	Belongs to the UPF0348 family
I6J12_RS07175	COG2226	methyltransferase
I6J12_RS07180	COG0799	negative regulation of ribosome biogenesis
I6J12_RS07185	COG1335	isochorismatase
I6J12_RS07190	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6J12_RS07195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J12_RS07200	COG1534	Rna-binding protein
I6J12_RS07205	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J12_RS07210	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6J12_RS07225	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J12_RS07230	COG0154	amidase activity
I6J12_RS07235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J12_RS07245	COG1335	isochorismatase
I6J12_RS07250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J12_RS07255	COG0436	Aminotransferase
I6J12_RS07260	COG0589	response to stress
I6J12_RS07265	COG0561	phosphatase activity
I6J12_RS07270	COG0252	asparaginase activity
I6J12_RS07275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J12_RS07280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J12_RS07285	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J12_RS07290	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J12_RS07300	COG0531	amino acid
I6J12_RS07305	COG1482	cell wall glycoprotein biosynthetic process
I6J12_RS07310	COG2188	Transcriptional regulator
I6J12_RS07315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J12_RS07320	COG2723	6-phospho-beta-galactosidase activity
I6J12_RS07325	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J12_RS07330	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J12_RS07335	COG1132	(ABC) transporter
I6J12_RS07350	COG0242	peptide deformylase activity
I6J12_RS07355	COG1940	carbohydrate kinase activity
I6J12_RS07360	COG2190	(PTS) system
I6J12_RS07360	COG1263	PTS System
I6J12_RS07360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J12_RS07365	COG1621	beta-fructofuranosidase activity
I6J12_RS07370	COG1609	Transcriptional regulator
I6J12_RS07375	COG0561	phosphatase activity
I6J12_RS07380	COG4608	Belongs to the ABC transporter superfamily
I6J12_RS07385	COG0444	Belongs to the ABC transporter superfamily
I6J12_RS07390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J12_RS07395	COG0601	transmembrane transport
I6J12_RS07400	COG4166	transmembrane transport
I6J12_RS07405	COG4166	transmembrane transport
I6J12_RS07415	COG0504	CTP synthase activity
I6J12_RS07420	COG3343	RNA polymerase activity
I6J12_RS07425	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6J12_RS07430	COG4475	Protein of unknown function (DUF436)
I6J12_RS07435	COG4720	Psort location CytoplasmicMembrane, score
I6J12_RS07440	COG0351	phosphomethylpyrimidine kinase
I6J12_RS07445	COG0101	tRNA pseudouridine synthase activity
I6J12_RS07455	COG0484	heat shock protein binding
I6J12_RS07465	COG0443	Heat shock 70 kDa protein
I6J12_RS07470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6J12_RS07475	COG1420	regulation of RNA biosynthetic process
I6J12_RS07480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J12_RS07485	COG3037	sugar-specific permease SgaT UlaA
I6J12_RS07495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J12_RS07500	COG0588	phosphoglycerate mutase activity
I6J12_RS07505	COG0588	phosphoglycerate mutase activity
I6J12_RS07510	COG2848	UPF0210 protein
I6J12_RS07515	COG3830	Belongs to the UPF0237 family
I6J12_RS07520	COG1609	Transcriptional regulator
I6J12_RS07535	COG3716	PTS system mannose fructose sorbose family IID component
I6J12_RS07540	COG3715	PTS system
I6J12_RS07545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J12_RS07550	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I6J12_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
I6J12_RS07585	COG5492	domain, Protein
I6J12_RS07595	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6J12_RS07690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6J12_RS07695	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J12_RS07705	COG3688	RNA-binding protein containing a PIN domain
I6J12_RS07715	COG3842	ATPase activity
I6J12_RS07725	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6J12_RS07730	COG0215	cysteine-tRNA ligase activity
I6J12_RS07740	COG1045	serine acetyltransferase
I6J12_RS07745	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J12_RS07750	COG1164	Oligoendopeptidase f
I6J12_RS07765	COG3118	belongs to the thioredoxin family
I6J12_RS07780	COG1187	pseudouridine synthase activity
I6J12_RS07815	COG0438	transferase activity, transferring glycosyl groups
I6J12_RS07850	COG0242	peptide deformylase activity
I6J12_RS07865	COG2176	DNA-directed DNA polymerase activity
I6J12_RS07875	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6J12_RS07880	COG1523	belongs to the glycosyl hydrolase 13 family
I6J12_RS07895	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J12_RS07930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J12_RS07935	COG0006	proline dipeptidase activity
I6J12_RS07945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6J12_RS07960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J12_RS07965	COG0629	single-stranded DNA binding
I6J12_RS07985	COG0588	phosphoglycerate mutase activity
I6J12_RS08010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J12_RS08020	COG1122	ATPase activity
I6J12_RS08045	COG5002	protein histidine kinase activity
I6J12_RS08050	COG0745	RESPONSE REGULATOR receiver
I6J12_RS08055	COG2723	6-phospho-beta-galactosidase activity
I6J12_RS08060	COG1304	FMN binding
I6J12_RS08065	COG0028	Belongs to the TPP enzyme family
I6J12_RS08070	COG1876	peptidase activity
I6J12_RS08090	COG3290	protein histidine kinase activity
I6J12_RS08115	COG0561	phosphatase activity
I6J12_RS08125	COG0346	lactoylglutathione lyase activity
I6J12_RS08150	COG2190	(PTS) system
I6J12_RS08150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J12_RS08150	COG1263	PTS System
I6J12_RS08155	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J12_RS08160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J12_RS08170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J12_RS08175	COG1940	carbohydrate kinase activity
I6J12_RS08210	COG0402	S-adenosylhomocysteine deaminase activity
I6J12_RS08215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J12_RS08215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6J12_RS08220	COG0167	dihydroorotate dehydrogenase activity
I6J12_RS08225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J12_RS08235	COG0668	transmembrane transport
I6J12_RS08240	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6J12_RS08295	COG3843	relaxase mobilization nuclease domain protein
I6J12_RS08345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J12_RS08345	COG0551	DNA topoisomerase type I activity
I6J12_RS08420	COG1484	DNA-dependent DNA replication
I6J12_RS08440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J12_RS08445	COG3118	belongs to the thioredoxin family
I6J12_RS08455	COG1193	negative regulation of DNA recombination
I6J12_RS08475	COG0681	Belongs to the peptidase S26 family
I6J12_RS08480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J12_RS08500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6J12_RS08505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J12_RS08530	COG1214	PFAM Peptidase M22, glycoprotease
I6J12_RS08550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J12_RS08555	COG0049	tRNA binding
I6J12_RS08560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6J12_RS08570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J12_RS08575	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6J12_RS08585	COG1564	THIamine pyrophosphokinase
I6J12_RS08595	COG1162	GTPase activity
I6J12_RS08610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6J12_RS08630	COG0084	hydrolase, TatD family'
I6J12_RS08635	COG0582	viral genome integration into host DNA
I6J12_RS08675	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6J12_RS08695	COG0594	ribonuclease P activity
I6J12_RS08705	COG0166	Belongs to the GPI family
I6J12_RS08745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6J12_RS08765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6J12_RS08770	COG0789	Transcriptional regulator
I6J12_RS08775	COG1063	alcohol dehydrogenase
I6J12_RS08790	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J12_RS08795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J12_RS08810	COG4463	regulation of RNA biosynthetic process
I6J12_RS08820	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J12_RS08825	COG0052	Belongs to the universal ribosomal protein uS2 family
I6J12_RS08835	COG0203	ribosomal protein L17
I6J12_RS08840	COG0202	RNA polymerase activity
I6J12_RS08845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J12_RS08850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J12_RS08855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6J12_RS08860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6J12_RS08865	COG0563	adenylate kinase activity
I6J12_RS08870	COG0201	protein transport
I6J12_RS08875	COG0200	Binds to the 23S rRNA
I6J12_RS08880	COG1841	ribosomal large subunit assembly
I6J12_RS08885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J12_RS08895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6J12_RS08900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6J12_RS08905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J12_RS08910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6J12_RS08915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J12_RS08920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6J12_RS08930	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J12_RS08935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6J12_RS08940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6J12_RS08945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6J12_RS08955	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6J12_RS08960	COG0089	rRNA binding
I6J12_RS08965	COG0088	Forms part of the polypeptide exit tunnel
I6J12_RS08970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6J12_RS08975	COG0051	transcription antitermination factor activity, RNA binding
I6J12_RS08990	COG0343	queuine tRNA-ribosyltransferase activity
I6J12_RS09005	COG1832	CoA-binding protein
I6J12_RS09010	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J12_RS09010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J12_RS09030	COG5002	protein histidine kinase activity
I6J12_RS09120	COG0602	queuosine metabolic process
I6J12_RS09145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J12_RS09155	COG0285	dihydrofolate synthase activity
I6J12_RS09160	COG3906	Belongs to the UPF0473 family
I6J12_RS09165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6J12_RS09170	COG4472	Bacterial protein of unknown function (DUF965)
I6J12_RS09185	COG1393	Belongs to the ArsC family
I6J12_RS09190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6J12_RS09195	COG1058	Belongs to the CinA family
I6J12_RS09195	COG1546	Belongs to the CinA family
I6J12_RS09205	COG0519	Catalyzes the synthesis of GMP from XMP
I6J12_RS09210	COG0632	four-way junction helicase activity
I6J12_RS09220	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6J12_RS09225	COG0582	viral genome integration into host DNA
I6J12_RS09235	COG1396	sequence-specific DNA binding
I6J12_RS09315	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6J12_RS09320	COG1438	arginine binding
I6J12_RS09325	COG0018	arginyl-trna synthetase
I6J12_RS09330	COG1780	Probably involved in ribonucleotide reductase function
I6J12_RS09340	COG0058	SHG alpha-glucan phosphorylase activity
I6J12_RS09345	COG1640	4-alpha-glucanotransferase
I6J12_RS09350	COG2182	Extracellular solute-binding protein
I6J12_RS09355	COG1175	transmembrane transport
I6J12_RS09360	COG3833	ABC-type maltose transport systems, permease component
I6J12_RS09365	COG5521	maltodextrose utilization protein MalA
I6J12_RS09370	COG1609	Transcriptional regulator
I6J12_RS09375	COG1523	belongs to the glycosyl hydrolase 13 family
I6J12_RS09380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J12_RS09400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6J12_RS09405	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J12_RS09465	COG0582	viral genome integration into host DNA
I6J12_RS09480	COG2807	transmembrane transport
I6J12_RS09485	COG2094	Belongs to the DNA glycosylase MPG family
I6J12_RS09490	COG0561	phosphatase activity
I6J12_RS09495	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6J12_RS09500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J12_RS09505	COG1696	Membrane protein involved in D-alanine export
I6J12_RS09565	COG0561	phosphatase activity
I6J12_RS09585	COG1011	Hydrolase
I6J12_RS09595	COG0305	Participates in initiation and elongation during chromosome replication
I6J12_RS09610	COG0445	tRNA wobble uridine modification
I6J12_RS09615	COG0482	sulfurtransferase activity
I6J12_RS09625	COG1760	l-serine dehydratase
I6J12_RS09630	COG1760	l-serine dehydratase
I6J12_RS09650	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6J12_RS09655	COG1122	ATPase activity
I6J12_RS09660	COG1122	ATPase activity
I6J12_RS09665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J12_RS09675	COG0612	Peptidase, M16
I6J12_RS09680	COG0612	Peptidase, M16
I6J12_RS09690	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J12_RS09695	COG0516	GMP reductase activity
I6J12_RS09695	COG0517	IMP dehydrogenase activity
I6J12_RS09700	COG0180	Tryptophanyl-tRNA synthetase
I6J12_RS09705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J12_RS09710	COG0149	triose-phosphate isomerase activity
I6J12_RS09720	COG0488	(ABC) transporter
I6J12_RS09760	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6J12_RS09765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J12_RS09770	COG1475	DNA binding
I6J12_RS09780	COG0592	DNA-directed DNA polymerase activity
I6J12_RS09795	COG0012	GTP binding
I6J12_RS09800	COG0193	aminoacyl-tRNA hydrolase activity
I6J12_RS09805	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J12_RS09810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J12_RS09825	COG0037	tRNA processing
I6J12_RS09830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6J12_RS09835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J12_RS09960	COG1792	Involved in formation and maintenance of cell shape
I6J12_RS09970	COG3942	CHAP domain
I6J12_RS09975	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6J12_RS09980	COG0436	Aminotransferase
I6J12_RS09985	COG1381	Involved in DNA repair and RecF pathway recombination
I6J12_RS09995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J12_RS10000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J12_RS10015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J12_RS10020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J12_RS10035	COG3942	CHAP domain
I6J12_RS10040	COG0151	Belongs to the GarS family
I6J12_RS10045	COG1683	Conserved Protein
I6J12_RS10050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J12_RS10070	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J12_RS10075	COG2376	Dihydroxyacetone kinase
I6J12_RS10085	COG2376	Dihydroxyacetone kinase
I6J12_RS10090	COG1461	Dihydroxyacetone kinase
I6J12_RS10095	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6J12_RS10100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J12_RS10120	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J12_RS10130	COG3716	PTS system mannose fructose sorbose family IID component
I6J12_RS10140	COG2222	sugar isomerase
I6J12_RS10145	COG3684	Belongs to the aldolase LacD family
I6J12_RS10160	COG2255	four-way junction helicase activity
I6J12_RS10170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J12_RS10185	COG1454	alcohol dehydrogenase
I6J12_RS10185	COG1012	belongs to the aldehyde dehydrogenase family
I6J12_RS10190	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6J12_RS10200	COG1175	transmembrane transport
I6J12_RS10205	COG0395	ABC-type sugar transport system, permease component
I6J12_RS10220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J12_RS10240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J12_RS10240	COG1263	PTS System
I6J12_RS10245	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6J12_RS10260	COG1269	ATP hydrolysis coupled proton transport
I6J12_RS10265	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6J12_RS10275	COG1527	subunit (C
I6J12_RS10280	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6J12_RS10290	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I6J12_RS10295	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I6J12_RS10300	COG1394	ATPase activity, coupled to movement of substances
I6J12_RS10305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J12_RS10325	COG3759	membrane
I6J12_RS10330	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J12_RS10355	COG1846	Transcriptional regulator
I6J12_RS10360	COG1121	(ABC) transporter
I6J12_RS10365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J12_RS10370	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6J12_RS10370	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J12_RS10390	COG0564	pseudouridine synthase activity
I6J12_RS10395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J12_RS10400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J12_RS10515	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J12_RS10515	COG3942	CHAP domain
I6J12_RS10530	COG0433	COG0433 Predicted ATPase
I6J12_RS10570	COG4115	mRNA cleavage
I6J12_RS10580	COG1674	ftsk spoiiie
I6J12_RS10615	COG1396	sequence-specific DNA binding
I6J12_RS10645	COG1132	(ABC) transporter
I6J12_RS10660	COG2081	HI0933 family
I6J12_RS10675	COG0584	glycerophosphoryl diester phosphodiesterase
I6J12_RS10695	COG1131	(ABC) transporter
I6J12_RS10705	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6J12_RS10710	COG2936	dipeptidyl-peptidase activity
I6J12_RS10715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J12_RS10740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J12_RS10760	COG1304	FMN binding
I6J12_RS10770	COG3425	synthase
I6J12_RS10785	COG1882	Formate acetyltransferase
I6J12_RS10790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J12_RS10805	COG0756	dUTP diphosphatase activity
I6J12_RS10820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J12_RS10825	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J12_RS10830	COG3775	system Galactitol-specific IIC component
I6J12_RS10840	COG0235	Class ii aldolase
I6J12_RS10845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J12_RS10850	COG2171	N-acyltransferase activity
I6J12_RS10855	COG1473	amidohydrolase
I6J12_RS10860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J12_RS10870	COG2226	methyltransferase
I6J12_RS10875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6J12_RS10895	COG1136	(ABC) transporter
I6J12_RS10895	COG0577	efflux transmembrane transporter activity
I6J12_RS10900	COG0085	RNA polymerase activity
I6J12_RS10905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6J12_RS10910	COG0126	phosphoglycerate kinase activity
I6J12_RS10920	COG0789	Transcriptional regulator
I6J12_RS10925	COG0174	glutamine synthetase
I6J12_RS10935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J12_RS10940	COG1459	type II secretion system
I6J12_RS11000	COG0629	single-stranded DNA binding
I6J12_RS11075	COG1475	DNA binding