locus-tag	class	description
I6K87_RS00005	COG0708	Exodeoxyribonuclease III
I6K87_RS00030	COG4720	Psort location CytoplasmicMembrane, score
I6K87_RS00040	COG1122	ATPase activity
I6K87_RS00050	COG4221	oxidoreductase activity
I6K87_RS00055	COG1442	glycosyl transferase family 8
I6K87_RS00060	COG0357	Ribosomal RNA small subunit methyltransferase G
I6K87_RS00065	COG1704	LemA family
I6K87_RS00070	COG0501	Belongs to the peptidase M48B family
I6K87_RS00100	COG1131	(ABC) transporter
I6K87_RS00110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6K87_RS00115	COG0745	RESPONSE REGULATOR receiver
I6K87_RS00120	COG1263	PTS System
I6K87_RS00120	COG2190	(PTS) system
I6K87_RS00120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K87_RS00135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6K87_RS00145	COG1484	DNA-dependent DNA replication
I6K87_RS00155	COG1160	GTP binding
I6K87_RS00165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6K87_RS00175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K87_RS00190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K87_RS00210	COG1254	Belongs to the acylphosphatase family
I6K87_RS00215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K87_RS00240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6K87_RS00245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6K87_RS00260	COG4974	Belongs to the 'phage' integrase family
I6K87_RS00265	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6K87_RS00270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6K87_RS00275	COG1187	pseudouridine synthase activity
I6K87_RS00280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6K87_RS00295	COG2211	Major facilitator Superfamily
I6K87_RS00315	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6K87_RS00320	COG0671	phosphoesterase, PA-phosphatase related
I6K87_RS00330	COG1242	4 iron, 4 sulfur cluster binding
I6K87_RS00335	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K87_RS00345	COG0025	NhaP-type Na H and K H
I6K87_RS00355	COG0494	nUDIX hydrolase
I6K87_RS00370	COG0542	response to heat
I6K87_RS00375	COG4703	Protein of unknown function (DUF1797)
I6K87_RS00400	COG1136	(ABC) transporter
I6K87_RS00405	COG0577	efflux transmembrane transporter activity
I6K87_RS00410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6K87_RS00415	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K87_RS00425	COG1570	exodeoxyribonuclease VII activity
I6K87_RS00430	COG1722	exodeoxyribonuclease VII activity
I6K87_RS00440	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6K87_RS00445	COG1438	arginine binding
I6K87_RS00450	COG0497	DNA recombination
I6K87_RS00455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K87_RS00460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K87_RS00465	COG4604	ABC transporter, ATP-binding protein
I6K87_RS00470	COG4605	iron ion homeostasis
I6K87_RS00475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K87_RS00480	COG1307	EDD domain protein, DegV family
I6K87_RS00495	COG0588	phosphoglycerate mutase activity
I6K87_RS00500	COG0582	viral genome integration into host DNA
I6K87_RS00585	COG0768	penicillin binding
I6K87_RS00590	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6K87_RS00595	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K87_RS00600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K87_RS00625	COG3620	sequence-specific DNA binding
I6K87_RS00655	COG0513	Belongs to the DEAD box helicase family
I6K87_RS00665	COG1349	DNA-binding transcription factor activity
I6K87_RS00670	COG0698	ribose 5-phosphate isomerase
I6K87_RS00690	COG3775	system Galactitol-specific IIC component
I6K87_RS00700	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6K87_RS00705	COG3711	transcriptional antiterminator
I6K87_RS00715	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K87_RS00720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K87_RS00720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K87_RS00725	COG3867	Arabinogalactan endo-beta-1,4-galactanase
I6K87_RS00730	COG2827	Endonuclease containing a URI domain
I6K87_RS00735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6K87_RS00740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K87_RS00745	COG0204	Acyl-transferase
I6K87_RS00760	COG1476	TRANSCRIPTIONal
I6K87_RS00775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K87_RS00785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K87_RS00795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K87_RS00800	COG0322	excinuclease ABC activity
I6K87_RS00810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K87_RS00820	COG1573	uracil-dna glycosylase
I6K87_RS00830	COG1732	Glycine betaine
I6K87_RS00835	COG1125	glycine betaine transport
I6K87_RS00860	COG0254	rRNA binding
I6K87_RS00865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6K87_RS00870	COG0716	FMN binding
I6K87_RS00890	COG1309	transcriptional regulator
I6K87_RS00895	COG1136	(ABC) transporter
I6K87_RS00910	COG1959	2 iron, 2 sulfur cluster binding
I6K87_RS00915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K87_RS00920	COG1349	DNA-binding transcription factor activity
I6K87_RS00930	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K87_RS00940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K87_RS00945	COG1882	Formate acetyltransferase
I6K87_RS00985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K87_RS00990	COG0406	alpha-ribazole phosphatase activity
I6K87_RS00995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K87_RS01010	COG0772	Belongs to the SEDS family
I6K87_RS01015	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6K87_RS01030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6K87_RS01045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6K87_RS01060	COG0813	purine-nucleoside phosphorylase activity
I6K87_RS01070	COG1368	sulfuric ester hydrolase activity
I6K87_RS01075	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6K87_RS01080	COG0710	3-dehydroquinate dehydratase activity
I6K87_RS01085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6K87_RS01090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6K87_RS01095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6K87_RS01100	COG0730	response to heat
I6K87_RS01110	COG0287	Prephenate dehydrogenase
I6K87_RS01115	COG3679	Belongs to the UPF0342 family
I6K87_RS01125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6K87_RS01130	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6K87_RS01135	COG0077	Prephenate dehydratase
I6K87_RS01145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6K87_RS01165	COG1484	DNA-dependent DNA replication
I6K87_RS01200	COG1129	ABC transporter
I6K87_RS01205	COG1132	(ABC) transporter
I6K87_RS01205	COG2375	cellular response to nickel ion
I6K87_RS01210	COG1132	(ABC) transporter
I6K87_RS01300	COG0551	DNA topoisomerase type I activity
I6K87_RS01300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K87_RS01340	COG1309	transcriptional regulator
I6K87_RS01355	COG1129	ABC transporter
I6K87_RS01360	COG1132	(ABC) transporter
I6K87_RS01360	COG2375	cellular response to nickel ion
I6K87_RS01365	COG1132	(ABC) transporter
I6K87_RS01400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K87_RS01405	COG0492	ferredoxin-NADP+ reductase activity
I6K87_RS01415	COG1349	DNA-binding transcription factor activity
I6K87_RS01420	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K87_RS01425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K87_RS01425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K87_RS01425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K87_RS01435	COG1307	EDD domain protein, DegV family
I6K87_RS01440	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6K87_RS01445	COG0617	tRNA 3'-terminal CCA addition
I6K87_RS01450	COG0488	(ABC) transporter
I6K87_RS01465	COG0072	phenylalanine-tRNA ligase activity
I6K87_RS01465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K87_RS01480	COG1268	BioY protein
I6K87_RS01630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K87_RS01630	COG0551	DNA topoisomerase type I activity
I6K87_RS01670	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K87_RS01685	COG0640	Transcriptional regulator
I6K87_RS01695	COG1725	Transcriptional regulator
I6K87_RS01700	COG0842	Transport permease protein
I6K87_RS01700	COG1129	ABC transporter
I6K87_RS01720	COG1674	ftsk spoiiie
I6K87_RS01730	COG2946	Replication initiation factor
I6K87_RS01760	COG0789	Transcriptional regulator
I6K87_RS01775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6K87_RS01800	COG4974	Belongs to the 'phage' integrase family
I6K87_RS01825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K87_RS01835	COG1136	(ABC) transporter
I6K87_RS01840	COG0577	efflux transmembrane transporter activity
I6K87_RS01850	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6K87_RS01855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K87_RS01875	COG0300	oxidoreductase activity
I6K87_RS01890	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6K87_RS01890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K87_RS01900	COG1131	(ABC) transporter
I6K87_RS01905	COG1725	Transcriptional regulator
I6K87_RS01915	COG0205	6-phosphofructokinase activity
I6K87_RS01920	COG0469	pyruvate kinase activity
I6K87_RS01930	COG0765	amino acid transport
I6K87_RS01935	COG1126	abc transporter atp-binding protein
I6K87_RS01945	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6K87_RS01950	COG0210	DNA helicase
I6K87_RS01955	COG1051	belongs to the nudix hydrolase family
I6K87_RS01960	COG2378	regulation of single-species biofilm formation
I6K87_RS01965	COG1132	(ABC) transporter
I6K87_RS01965	COG2375	cellular response to nickel ion
I6K87_RS01970	COG1132	(ABC) transporter
I6K87_RS01985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6K87_RS01990	COG0196	riboflavin kinase activity
I6K87_RS01995	COG1393	Belongs to the ArsC family
I6K87_RS02000	COG4476	Belongs to the UPF0223 family
I6K87_RS02005	COG0483	inositol monophosphate 1-phosphatase activity
I6K87_RS02010	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6K87_RS02010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6K87_RS02020	COG0573	inorganic phosphate transmembrane transporter activity
I6K87_RS02025	COG0581	inorganic phosphate transmembrane transporter activity
I6K87_RS02030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K87_RS02035	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K87_RS02040	COG0704	Plays a role in the regulation of phosphate uptake
I6K87_RS02045	COG2003	Belongs to the UPF0758 family
I6K87_RS02050	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K87_RS02065	COG1104	cysteine desulfurase activity
I6K87_RS02070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K87_RS02080	COG2357	RelA SpoT domain protein
I6K87_RS02090	COG0564	pseudouridine synthase activity
I6K87_RS02095	COG0280	phosphate acetyltransferase
I6K87_RS02110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K87_RS02115	COG4684	Psort location CytoplasmicMembrane, score
I6K87_RS02120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K87_RS02130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6K87_RS02150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K87_RS02155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K87_RS02165	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6K87_RS02170	COG0222	ribosome binding
I6K87_RS02175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6K87_RS02180	COG0336	Belongs to the RNA methyltransferase TrmD family
I6K87_RS02190	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K87_RS02190	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K87_RS02205	COG1956	GAF domain-containing protein
I6K87_RS02210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K87_RS02225	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6K87_RS02225	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6K87_RS02230	COG1609	Transcriptional regulator
I6K87_RS02235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6K87_RS02245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K87_RS02245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K87_RS02255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6K87_RS02265	COG0726	polysaccharide deacetylase
I6K87_RS02275	COG0083	homoserine kinase activity
I6K87_RS02305	COG1940	carbohydrate kinase activity
I6K87_RS02330	COG0745	RESPONSE REGULATOR receiver
I6K87_RS02335	COG5002	protein histidine kinase activity
I6K87_RS02345	COG4187	Peptidase family M20/M25/M40
I6K87_RS02355	COG0268	Binds directly to 16S ribosomal RNA
I6K87_RS02360	COG1072	(Pantothenic acid kinase))
I6K87_RS02365	COG2813	Specifically methylates the guanine in position
I6K87_RS02375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6K87_RS02380	COG0295	cytidine deaminase activity
I6K87_RS02385	COG1744	ABC transporter substrate-binding protein PnrA-like
I6K87_RS02390	COG3845	ABC transporter
I6K87_RS02395	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6K87_RS02400	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6K87_RS02405	COG1272	protein, Hemolysin III
I6K87_RS02415	COG3022	response to hydroperoxide
I6K87_RS02425	COG1846	Transcriptional regulator
I6K87_RS02435	COG0436	Aminotransferase
I6K87_RS02445	COG0017	Asparaginyl-tRNA synthetase
I6K87_RS02450	COG2814	Major facilitator Superfamily
I6K87_RS02500	COG1309	transcriptional regulator
I6K87_RS02505	COG2131	deaminase
I6K87_RS02515	COG0737	Belongs to the 5'-nucleotidase family
I6K87_RS02520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6K87_RS02525	COG0187	DNA topoisomerase II activity
I6K87_RS02545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K87_RS02550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K87_RS02570	COG0539	negative regulation of cytoplasmic translation
I6K87_RS02585	COG0039	L-malate dehydrogenase activity
I6K87_RS02590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K87_RS02595	COG3764	Sortase (surface protein transpeptidase)
I6K87_RS02600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K87_RS02605	COG1960	acyl-CoA dehydrogenase activity
I6K87_RS02610	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K87_RS02615	COG0183	Belongs to the thiolase family
I6K87_RS02620	COG1024	Enoyl-CoA hydratase
I6K87_RS02630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K87_RS02635	COG0583	DNA-binding transcription factor activity
I6K87_RS02640	COG1960	acyl-CoA dehydrogenase activity
I6K87_RS02645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K87_RS02650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6K87_RS02660	COG3711	transcriptional antiterminator
I6K87_RS02665	COG0110	maltose O-acetyltransferase activity
I6K87_RS02670	COG0758	DNA mediated transformation
I6K87_RS02675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K87_RS02680	COG0135	phosphoribosylanthranilate isomerase activity
I6K87_RS02685	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6K87_RS02705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6K87_RS02710	COG0022	dehydrogenase e1 component
I6K87_RS02715	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K87_RS02720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K87_RS02725	COG0095	Lipoate-protein ligase
I6K87_RS02730	COG4974	Belongs to the 'phage' integrase family
I6K87_RS02735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K87_RS02745	COG2188	Transcriptional regulator
I6K87_RS02770	COG0741	lytic transglycosylase activity
I6K87_RS02780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6K87_RS02790	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K87_RS02795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6K87_RS02800	COG1435	thymidine kinase activity
I6K87_RS02805	COG1942	4-Oxalocrotonate Tautomerase
I6K87_RS02810	COG0534	Mate efflux family protein
I6K87_RS02815	COG2233	PERMEase
I6K87_RS02820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6K87_RS02830	COG0038	chloride channel
I6K87_RS02850	COG0745	RESPONSE REGULATOR receiver
I6K87_RS02855	COG2205	protein histidine kinase activity
I6K87_RS02875	COG0431	NADPH-dependent FMN reductase
I6K87_RS02875	COG1053	succinate dehydrogenase
I6K87_RS02875	COG3976	FMN-binding domain protein
I6K87_RS02885	COG4555	ABC transporter
I6K87_RS02900	COG2972	Histidine kinase
I6K87_RS02905	COG2207	Transcriptional regulator
I6K87_RS02905	COG4753	response regulator
I6K87_RS02910	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6K87_RS02910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6K87_RS02915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K87_RS02920	COG0785	Cytochrome C biogenesis protein
I6K87_RS02925	COG1114	Component of the transport system for branched-chain amino acids
I6K87_RS02930	COG2151	metal-sulfur cluster biosynthetic enzyme
I6K87_RS02935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K87_RS02940	COG0358	DNA primase activity
I6K87_RS02945	COG1970	mechanosensitive ion channel activity
I6K87_RS02950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K87_RS02965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K87_RS02970	COG1132	(ABC) transporter
I6K87_RS02975	COG1132	(ABC) transporter
I6K87_RS02980	COG2315	Protein conserved in bacteria
I6K87_RS02985	COG3142	Participates in the control of copper homeostasis
I6K87_RS03000	COG1827	regulation of RNA biosynthetic process
I6K87_RS03010	COG1837	Belongs to the UPF0109 family
I6K87_RS03015	COG0228	four-way junction DNA binding
I6K87_RS03020	COG1523	belongs to the glycosyl hydrolase 13 family
I6K87_RS03025	COG1597	lipid kinase activity
I6K87_RS03030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6K87_RS03035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K87_RS03040	COG4708	membrane
I6K87_RS03045	COG2246	polysaccharide biosynthetic process
I6K87_RS03055	COG1846	Transcriptional regulator
I6K87_RS03065	COG0024	Methionine aminopeptidase
I6K87_RS03070	COG4109	DRTGG domain
I6K87_RS03080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6K87_RS03085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6K87_RS03090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6K87_RS03095	COG1051	belongs to the nudix hydrolase family
I6K87_RS03100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6K87_RS03120	COG2333	competence protein COMEC
I6K87_RS03120	COG0658	competence protein
I6K87_RS03125	COG1555	photosystem II stabilization
I6K87_RS03135	COG0557	exoribonuclease II activity
I6K87_RS03145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6K87_RS03150	COG2814	Major facilitator Superfamily
I6K87_RS03155	COG0237	dephospho-CoA kinase activity
I6K87_RS03160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6K87_RS03185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6K87_RS03190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K87_RS03195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6K87_RS03200	COG1132	(ABC) transporter
I6K87_RS03205	COG1132	(ABC) transporter
I6K87_RS03225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K87_RS03230	COG0686	Belongs to the AlaDH PNT family
I6K87_RS03250	COG1702	phosphate starvation-inducible protein PhoH
I6K87_RS03255	COG4479	Belongs to the UPF0346 family
I6K87_RS03270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6K87_RS03280	COG0284	orotidine-5'-phosphate decarboxylase activity
I6K87_RS03285	COG0167	dihydroorotate dehydrogenase activity
I6K87_RS03290	COG0543	2 iron, 2 sulfur cluster binding
I6K87_RS03320	COG2814	Major facilitator Superfamily
I6K87_RS03340	COG3843	relaxase mobilization nuclease domain protein
I6K87_RS03445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6K87_RS03450	COG0505	Belongs to the CarA family
I6K87_RS03455	COG0540	Belongs to the ATCase OTCase family
I6K87_RS03465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6K87_RS03470	COG1481	regulation of sporulation
I6K87_RS03475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6K87_RS03480	COG1660	Displays ATPase and GTPase activities
I6K87_RS03500	COG0647	UMP catabolic process
I6K87_RS03510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K87_RS03520	COG1131	(ABC) transporter
I6K87_RS03535	COG0556	nucleotide-excision repair
I6K87_RS03555	COG0488	(ABC) transporter
I6K87_RS03560	COG1132	(ABC) transporter
I6K87_RS03570	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6K87_RS03570	COG1388	LysM domain
I6K87_RS03575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6K87_RS03590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K87_RS03595	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6K87_RS03600	COG0038	chloride channel
I6K87_RS03625	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K87_RS03630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K87_RS03635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6K87_RS03640	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6K87_RS03645	COG0564	pseudouridine synthase activity
I6K87_RS03655	COG0583	DNA-binding transcription factor activity
I6K87_RS03660	COG1937	Protein conserved in bacteria
I6K87_RS03670	COG1054	Belongs to the UPF0176 family
I6K87_RS03675	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K87_RS03680	COG0425	Belongs to the sulfur carrier protein TusA family
I6K87_RS03680	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K87_RS03750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6K87_RS03760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6K87_RS03765	COG0301	tRNA thio-modification
I6K87_RS03770	COG1104	cysteine desulfurase activity
I6K87_RS03775	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6K87_RS03780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6K87_RS03785	COG0517	IMP dehydrogenase activity
I6K87_RS03790	COG0574	Belongs to the PEP-utilizing enzyme family
I6K87_RS03790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K87_RS03805	COG1177	transmembrane transport
I6K87_RS03810	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K87_RS03815	COG3842	ATPase activity
I6K87_RS03820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K87_RS03830	COG0481	GTPase activity
I6K87_RS03835	COG0561	phosphatase activity
I6K87_RS03840	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K87_RS03850	COG0572	uridine kinase
I6K87_RS03855	COG0673	inositol 2-dehydrogenase activity
I6K87_RS03865	COG0726	polysaccharide deacetylase
I6K87_RS03870	COG0346	lactoylglutathione lyase activity
I6K87_RS03880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6K87_RS03890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6K87_RS03915	COG0560	Phosphoserine phosphatase
I6K87_RS03920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K87_RS03930	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6K87_RS03935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K87_RS03940	COG3442	glutamine amidotransferase
I6K87_RS03945	COG2814	Major facilitator Superfamily
I6K87_RS03960	COG0488	(ABC) transporter
I6K87_RS03985	COG0826	peptidase U32
I6K87_RS04010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6K87_RS04015	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6K87_RS04030	COG3091	SprT-like family
I6K87_RS04065	COG0701	Predicted permease
I6K87_RS04070	COG3689	TIGRFAM TIGR03943 family protein
I6K87_RS04075	COG0477	Major facilitator Superfamily
I6K87_RS04080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K87_RS04090	COG0552	protein localization to endoplasmic reticulum
I6K87_RS04095	COG0561	phosphatase activity
I6K87_RS04100	COG0561	phosphatase activity
I6K87_RS04105	COG1196	nuclear chromosome segregation
I6K87_RS04110	COG0571	ribonuclease III activity
I6K87_RS04125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K87_RS04130	COG5002	protein histidine kinase activity
I6K87_RS04135	COG0745	RESPONSE REGULATOR receiver
I6K87_RS04145	COG0438	transferase activity, transferring glycosyl groups
I6K87_RS04155	COG1609	Transcriptional regulator
I6K87_RS04160	COG0006	proline dipeptidase activity
I6K87_RS04165	COG1368	sulfuric ester hydrolase activity
I6K87_RS04200	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6K87_RS04205	COG0463	Glycosyl transferase, family 2
I6K87_RS04220	COG1216	Glycosyl transferase, family 2
I6K87_RS04220	COG1442	glycosyl transferase family 8
I6K87_RS04235	COG0463	Glycosyl transferase, family 2
I6K87_RS04240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6K87_RS04245	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K87_RS04250	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K87_RS04260	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K87_RS04270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6K87_RS04275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K87_RS04280	COG2384	SAM-dependent methyltransferase
I6K87_RS04290	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6K87_RS04295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6K87_RS04300	COG1346	cytolysis
I6K87_RS04325	COG1132	(ABC) transporter
I6K87_RS04345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6K87_RS04365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6K87_RS04370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6K87_RS04375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6K87_RS04380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6K87_RS04385	COG0356	it plays a direct role in the translocation of protons across the membrane
I6K87_RS04395	COG0058	SHG alpha-glucan phosphorylase activity
I6K87_RS04400	COG0297	glycogen (starch) synthase activity
I6K87_RS04405	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6K87_RS04410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6K87_RS04415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6K87_RS04420	COG1074	ATP-dependent DNA helicase activity
I6K87_RS04425	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6K87_RS04430	COG1668	transmembrane transport
I6K87_RS04435	COG4152	abc transporter atp-binding protein
I6K87_RS04440	COG4443	Transcriptional Coactivator p15 (PC4)
I6K87_RS04450	COG1129	ABC transporter
I6K87_RS04465	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6K87_RS04470	COG3527	Alpha-acetolactate decarboxylase
I6K87_RS04475	COG0028	Belongs to the TPP enzyme family
I6K87_RS04485	COG0628	permease
I6K87_RS04490	COG3850	Histidine kinase
I6K87_RS04490	COG5002	protein histidine kinase activity
I6K87_RS04495	COG0745	RESPONSE REGULATOR receiver
I6K87_RS04500	COG2706	6-phosphogluconolactonase activity
I6K87_RS04505	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6K87_RS04510	COG0187	DNA topoisomerase II activity
I6K87_RS04525	COG0772	Belongs to the SEDS family
I6K87_RS04535	COG1199	ATP-dependent helicase activity
I6K87_RS04535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K87_RS04545	COG2177	Part of the ABC transporter FtsEX involved in
I6K87_RS04550	COG2884	Cell division ATP-binding protein ftsE
I6K87_RS04560	COG0561	phosphatase activity
I6K87_RS04595	COG1078	dGTPase activity
I6K87_RS04605	COG2348	transferase activity, transferring amino-acyl groups
I6K87_RS04625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K87_RS04635	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6K87_RS04645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K87_RS04650	COG4122	O-methyltransferase activity
I6K87_RS04670	COG2723	6-phospho-beta-galactosidase activity
I6K87_RS04685	COG0363	glucosamine-6-phosphate deaminase activity
I6K87_RS04690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6K87_RS04695	COG1438	arginine binding
I6K87_RS04700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K87_RS04705	COG1288	antiporter activity
I6K87_RS04710	COG0549	Belongs to the carbamate kinase family
I6K87_RS04715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K87_RS04745	COG2274	protein secretion by the type I secretion system
I6K87_RS04750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K87_RS04755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K87_RS04760	COG1466	dna polymerase III delta subunit
I6K87_RS04765	COG2996	Protein conserved in bacteria
I6K87_RS04770	COG0233	cytoplasmic translational termination
I6K87_RS04775	COG0528	UMP kinase activity
I6K87_RS04780	COG0538	isocitrate dehydrogenase activity
I6K87_RS04785	COG0372	Belongs to the citrate synthase family
I6K87_RS04790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K87_RS04795	COG0081	regulation of translation
I6K87_RS04810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K87_RS04815	COG1674	ftsk spoiiie
I6K87_RS04815	COG0697	spore germination
I6K87_RS04820	COG1983	PspC domain protein
I6K87_RS04830	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K87_RS04835	COG0488	(ABC) transporter
I6K87_RS04845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K87_RS04860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6K87_RS04885	COG1028	Short-chain dehydrogenase reductase Sdr
I6K87_RS04920	COG0531	amino acid
I6K87_RS04925	COG0577	efflux transmembrane transporter activity
I6K87_RS04930	COG1136	(ABC) transporter
I6K87_RS04955	COG0577	efflux transmembrane transporter activity
I6K87_RS04960	COG1136	(ABC) transporter
I6K87_RS04975	COG0745	RESPONSE REGULATOR receiver
I6K87_RS04985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K87_RS04985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K87_RS04995	COG1393	Belongs to the ArsC family
I6K87_RS05000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K87_RS05010	COG4467	Involved in initiation control of chromosome replication
I6K87_RS05015	COG0470	DNA polymerase III
I6K87_RS05020	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K87_RS05025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6K87_RS05030	COG0517	IMP dehydrogenase activity
I6K87_RS05045	COG4177	L-phenylalanine transmembrane transporter activity
I6K87_RS05065	COG0740	serine-type endopeptidase activity
I6K87_RS05070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6K87_RS05075	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K87_RS05080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K87_RS05085	COG0626	cystathionine gamma-synthase activity
I6K87_RS05090	COG2244	polysaccharide biosynthetic process
I6K87_RS05095	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K87_RS05120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K87_RS05130	COG0366	Alpha amylase catalytic
I6K87_RS05135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K87_RS05135	COG1263	PTS System
I6K87_RS05140	COG2188	Transcriptional regulator
I6K87_RS05145	COG1253	flavin adenine dinucleotide binding
I6K87_RS05155	COG0628	permease
I6K87_RS05165	COG1846	Transcriptional regulator
I6K87_RS05170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6K87_RS05175	COG3599	regulation of cell shape
I6K87_RS05190	COG1799	cell septum assembly
I6K87_RS05195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K87_RS05200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K87_RS05210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K87_RS05215	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6K87_RS05220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6K87_RS05230	COG1217	gtp-binding protein TYPA
I6K87_RS05235	COG1187	pseudouridine synthase activity
I6K87_RS05270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6K87_RS05275	COG4470	Protein conserved in bacteria
I6K87_RS05290	COG1674	ftsk spoiiie
I6K87_RS05300	COG2946	Replication initiation factor
I6K87_RS05330	COG0741	lytic transglycosylase activity
I6K87_RS05330	COG0791	NLP P60 protein
I6K87_RS05380	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6K87_RS05385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6K87_RS05390	COG0742	ribosomal rna small subunit methyltransferase
I6K87_RS05400	COG1040	competence protein
I6K87_RS05405	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6K87_RS05410	COG1739	Uncharacterized protein family UPF0029
I6K87_RS05425	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6K87_RS05430	COG0525	valine-tRNA ligase activity
I6K87_RS05440	COG0519	Catalyzes the synthesis of GMP from XMP
I6K87_RS05460	COG2070	2-Nitropropane dioxygenase
I6K87_RS05470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6K87_RS05475	COG2137	regulation of response to DNA damage stimulus
I6K87_RS05480	COG3557	Belongs to the UPF0374 family
I6K87_RS05490	COG1185	polyribonucleotide nucleotidyltransferase activity
I6K87_RS05505	COG4585	Histidine kinase
I6K87_RS05515	COG0515	serine threonine protein kinase
I6K87_RS05515	COG2815	serine threonine protein kinase
I6K87_RS05520	COG0631	protein serine/threonine phosphatase activity
I6K87_RS05525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6K87_RS05525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6K87_RS05530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6K87_RS05535	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K87_RS05540	COG1758	RNA polymerase activity
I6K87_RS05545	COG0194	GDP metabolic process
I6K87_RS05550	COG1418	mRNA catabolic process
I6K87_RS05560	COG3634	alkyl hydroperoxide reductase activity
I6K87_RS05565	COG0450	alkyl hydroperoxide reductase
I6K87_RS05575	COG0116	Belongs to the methyltransferase superfamily
I6K87_RS05585	COG3599	regulation of cell shape
I6K87_RS05590	COG4474	Belongs to the UPF0398 family
I6K87_RS05595	COG3331	DNA recombination
I6K87_RS05600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K87_RS05605	COG3579	cysteine-type endopeptidase activity
I6K87_RS05610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6K87_RS05615	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6K87_RS05620	COG1113	amino acid transport
I6K87_RS05625	COG0492	ferredoxin-NADP+ reductase activity
I6K87_RS05635	COG1126	abc transporter atp-binding protein
I6K87_RS05645	COG0513	Belongs to the DEAD box helicase family
I6K87_RS05650	COG1686	Belongs to the peptidase S11 family
I6K87_RS05660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K87_RS05665	COG0719	Fe-S assembly protein
I6K87_RS05675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K87_RS05680	COG4862	establishment of competence for transformation
I6K87_RS05700	COG1567	CRISPR-associated RAMP protein, Csm4 family
I6K87_RS05705	COG1337	RAMP superfamily
I6K87_RS05725	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6K87_RS05735	COG1968	undecaprenyl-diphosphatase activity
I6K87_RS05745	COG0765	amino acid transport
I6K87_RS05750	COG1126	abc transporter atp-binding protein
I6K87_RS05765	COG2197	response regulator
I6K87_RS05770	COG4585	Histidine kinase
I6K87_RS05780	COG1131	(ABC) transporter
I6K87_RS05785	COG1461	Dihydroxyacetone kinase
I6K87_RS05795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6K87_RS05820	COG0191	fructose-bisphosphate aldolase activity
I6K87_RS05830	COG4166	transmembrane transport
I6K87_RS05840	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K87_RS05845	COG0768	penicillin binding
I6K87_RS05855	COG0275	rRNA processing
I6K87_RS05865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K87_RS05880	COG0751	glycine-tRNA ligase activity
I6K87_RS05885	COG0752	glycyl-tRNA synthetase alpha subunit
I6K87_RS05910	COG0656	L-ascorbic acid biosynthetic process
I6K87_RS05925	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6K87_RS05930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6K87_RS05945	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6K87_RS05950	COG0195	Participates in both transcription termination and antitermination
I6K87_RS05955	COG0779	Required for maturation of 30S ribosomal subunits
I6K87_RS05965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6K87_RS05970	COG0510	thiamine kinase activity
I6K87_RS05980	COG1131	(ABC) transporter
I6K87_RS05985	COG0537	adenosine 5'-monophosphoramidase activity
I6K87_RS05995	COG1316	TRANSCRIPTIONal
I6K87_RS06005	COG0802	atpase or kinase
I6K87_RS06010	COG2252	PERMEase
I6K87_RS06020	COG0561	phosphatase activity
I6K87_RS06030	COG3715	PTS system
I6K87_RS06035	COG3716	PTS system mannose fructose sorbose family IID component
I6K87_RS06050	COG0586	Pfam SNARE associated Golgi protein
I6K87_RS06055	COG0825	malonyl-CoA metabolic process
I6K87_RS06060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6K87_RS06065	COG0439	Biotin carboxylase
I6K87_RS06070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6K87_RS06080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K87_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
I6K87_RS06090	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K87_RS06095	COG2070	2-Nitropropane dioxygenase
I6K87_RS06105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6K87_RS06115	COG1024	Enoyl-CoA hydratase
I6K87_RS06120	COG0527	aspartate kinase activity
I6K87_RS06155	COG1132	(ABC) transporter
I6K87_RS06160	COG4988	ABC transporter
I6K87_RS06165	COG3590	peptidase
I6K87_RS06190	COG1490	D-aminoacyl-tRNA deacylase activity
I6K87_RS06205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K87_RS06220	COG1051	belongs to the nudix hydrolase family
I6K87_RS06230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K87_RS06245	COG1418	mRNA catabolic process
I6K87_RS06250	COG1428	Deoxynucleoside kinase
I6K87_RS06265	COG0459	protein refolding
I6K87_RS06270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6K87_RS06280	COG3716	PTS system mannose fructose sorbose family IID component
I6K87_RS06285	COG3715	PTS system
I6K87_RS06305	COG2197	response regulator
I6K87_RS06310	COG4585	Histidine kinase
I6K87_RS06325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K87_RS06330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K87_RS06340	COG1363	Peptidase, m42
I6K87_RS06350	COG0285	dihydrofolate synthase activity
I6K87_RS06360	COG0442	prolyl-tRNA aminoacylation
I6K87_RS06365	COG0750	zinc metalloprotease
I6K87_RS06370	COG4589	Belongs to the CDS family
I6K87_RS06375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K87_RS06385	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
I6K87_RS06390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K87_RS06410	COG3623	hexulose-6-phosphate isomerase
I6K87_RS06420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K87_RS06430	COG3037	sugar-specific permease SgaT UlaA
I6K87_RS06445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K87_RS06475	COG4537	Required for transformation and DNA binding
I6K87_RS06480	COG1459	type II secretion system
I6K87_RS06485	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K87_RS06495	COG0174	glutamine synthetase
I6K87_RS06500	COG0789	Transcriptional regulator
I6K87_RS06520	COG0126	phosphoglycerate kinase activity
I6K87_RS06525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6K87_RS06530	COG0085	RNA polymerase activity
I6K87_RS06540	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6K87_RS06545	COG2226	methyltransferase
I6K87_RS06555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K87_RS06560	COG1473	amidohydrolase
I6K87_RS06565	COG2171	N-acyltransferase activity
I6K87_RS06570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K87_RS06580	COG0756	dUTP diphosphatase activity
I6K87_RS06595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K87_RS06600	COG1882	Formate acetyltransferase
I6K87_RS06615	COG3425	synthase
I6K87_RS06625	COG1304	FMN binding
I6K87_RS06645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K87_RS06660	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K87_RS06670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6K87_RS06675	COG0584	glycerophosphoryl diester phosphodiesterase
I6K87_RS06680	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K87_RS06690	COG2081	HI0933 family
I6K87_RS06695	COG0789	Transcriptional regulator
I6K87_RS06725	COG4115	mRNA cleavage
I6K87_RS06860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6K87_RS06865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K87_RS06870	COG0564	pseudouridine synthase activity
I6K87_RS06890	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K87_RS06890	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6K87_RS06895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K87_RS06900	COG1121	(ABC) transporter
I6K87_RS06905	COG1846	Transcriptional regulator
I6K87_RS06935	COG1914	H( )-stimulated, divalent metal cation uptake system
I6K87_RS06940	COG3759	membrane
I6K87_RS06950	COG0131	Imidazoleglycerol-phosphate dehydratase
I6K87_RS06950	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K87_RS06965	COG1309	transcriptional regulator
I6K87_RS06980	COG1394	ATPase activity, coupled to movement of substances
I6K87_RS06985	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I6K87_RS06990	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I6K87_RS07005	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
I6K87_RS07010	COG1527	subunit (C
I6K87_RS07020	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6K87_RS07025	COG1269	ATP hydrolysis coupled proton transport
I6K87_RS07045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K87_RS07060	COG0395	ABC-type sugar transport system, permease component
I6K87_RS07065	COG1175	transmembrane transport
I6K87_RS07075	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6K87_RS07085	COG1454	alcohol dehydrogenase
I6K87_RS07090	COG1454	alcohol dehydrogenase
I6K87_RS07090	COG1012	belongs to the aldehyde dehydrogenase family
I6K87_RS07105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K87_RS07115	COG2255	four-way junction helicase activity
I6K87_RS07125	COG3684	Belongs to the aldolase LacD family
I6K87_RS07130	COG2222	sugar isomerase
I6K87_RS07140	COG3716	PTS system mannose fructose sorbose family IID component
I6K87_RS07150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K87_RS07170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K87_RS07175	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6K87_RS07180	COG1461	Dihydroxyacetone kinase
I6K87_RS07185	COG2376	Dihydroxyacetone kinase
I6K87_RS07195	COG2376	Dihydroxyacetone kinase
I6K87_RS07200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K87_RS07225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K87_RS07230	COG1683	Conserved Protein
I6K87_RS07235	COG0151	Belongs to the GarS family
I6K87_RS07240	COG3942	CHAP domain
I6K87_RS07255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K87_RS07260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6K87_RS07270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6K87_RS07275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6K87_RS07280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K87_RS07290	COG1381	Involved in DNA repair and RecF pathway recombination
I6K87_RS07295	COG0436	Aminotransferase
I6K87_RS07300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K87_RS07305	COG3942	CHAP domain
I6K87_RS07315	COG1792	Involved in formation and maintenance of cell shape
I6K87_RS07435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K87_RS07440	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6K87_RS07445	COG0037	tRNA processing
I6K87_RS07460	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K87_RS07465	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K87_RS07470	COG0193	aminoacyl-tRNA hydrolase activity
I6K87_RS07475	COG0012	GTP binding
I6K87_RS07490	COG0592	DNA-directed DNA polymerase activity
I6K87_RS07500	COG1475	DNA binding
I6K87_RS07505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K87_RS07510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6K87_RS07550	COG0488	(ABC) transporter
I6K87_RS07560	COG0149	triose-phosphate isomerase activity
I6K87_RS07565	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K87_RS07570	COG0180	Tryptophanyl-tRNA synthetase
I6K87_RS07575	COG0517	IMP dehydrogenase activity
I6K87_RS07575	COG0516	GMP reductase activity
I6K87_RS07580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6K87_RS07590	COG0612	Peptidase, M16
I6K87_RS07595	COG0612	Peptidase, M16
I6K87_RS07605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K87_RS07610	COG1122	ATPase activity
I6K87_RS07615	COG1122	ATPase activity
I6K87_RS07620	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6K87_RS07635	COG1760	l-serine dehydratase
I6K87_RS07640	COG1760	l-serine dehydratase
I6K87_RS07650	COG0482	sulfurtransferase activity
I6K87_RS07655	COG0445	tRNA wobble uridine modification
I6K87_RS07670	COG0305	Participates in initiation and elongation during chromosome replication
I6K87_RS07680	COG1011	Hydrolase
I6K87_RS07700	COG0561	phosphatase activity
I6K87_RS07765	COG1696	Membrane protein involved in D-alanine export
I6K87_RS07770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K87_RS07775	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6K87_RS07780	COG0561	phosphatase activity
I6K87_RS07785	COG2094	Belongs to the DNA glycosylase MPG family
I6K87_RS07790	COG2807	transmembrane transport
I6K87_RS07825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6K87_RS07830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6K87_RS07835	COG0124	histidyl-tRNA synthetase
I6K87_RS07850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6K87_RS07855	COG1523	belongs to the glycosyl hydrolase 13 family
I6K87_RS07860	COG1609	Transcriptional regulator
I6K87_RS07865	COG5521	maltodextrose utilization protein MalA
I6K87_RS07870	COG3833	ABC-type maltose transport systems, permease component
I6K87_RS07875	COG1175	transmembrane transport
I6K87_RS07880	COG2182	Extracellular solute-binding protein
I6K87_RS07885	COG1640	4-alpha-glucanotransferase
I6K87_RS07890	COG0058	SHG alpha-glucan phosphorylase activity
I6K87_RS07900	COG1780	Probably involved in ribonucleotide reductase function
I6K87_RS07905	COG0018	arginyl-trna synthetase
I6K87_RS07910	COG1438	arginine binding
I6K87_RS07915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6K87_RS07930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6K87_RS07935	COG0632	four-way junction helicase activity
I6K87_RS07940	COG2818	Glycosylase
I6K87_RS07950	COG1058	Belongs to the CinA family
I6K87_RS07950	COG1546	Belongs to the CinA family
I6K87_RS07955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6K87_RS07960	COG1393	Belongs to the ArsC family
I6K87_RS07975	COG4472	Bacterial protein of unknown function (DUF965)
I6K87_RS07980	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6K87_RS07985	COG3906	Belongs to the UPF0473 family
I6K87_RS07990	COG0285	dihydrofolate synthase activity
I6K87_RS08000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K87_RS08030	COG0602	queuosine metabolic process
I6K87_RS08040	COG4464	protein tyrosine phosphatase activity
I6K87_RS08045	COG3944	biosynthesis protein
I6K87_RS08065	COG0297	glycogen (starch) synthase activity
I6K87_RS08075	COG1216	Glycosyl transferase, family 2
I6K87_RS08075	COG1442	glycosyl transferase family 8
I6K87_RS08080	COG1216	Glycosyl transferase, family 2
I6K87_RS08080	COG1442	glycosyl transferase family 8
I6K87_RS08095	COG3274	enterobacterial common antigen metabolic process
I6K87_RS08100	COG0562	UDP-galactopyranose mutase
I6K87_RS08110	COG0438	transferase activity, transferring glycosyl groups
I6K87_RS08145	COG5002	protein histidine kinase activity
I6K87_RS08150	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K87_RS08150	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K87_RS08155	COG1832	CoA-binding protein
I6K87_RS08170	COG0343	queuine tRNA-ribosyltransferase activity
I6K87_RS08175	COG0572	uridine kinase
I6K87_RS08190	COG0051	transcription antitermination factor activity, RNA binding
I6K87_RS08195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6K87_RS08200	COG0088	Forms part of the polypeptide exit tunnel
I6K87_RS08205	COG0089	rRNA binding
I6K87_RS08210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6K87_RS08220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6K87_RS08225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6K87_RS08230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6K87_RS08235	COG0255	Belongs to the universal ribosomal protein uL29 family
I6K87_RS08245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6K87_RS08250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6K87_RS08255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6K87_RS08260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6K87_RS08265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6K87_RS08270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6K87_RS08280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6K87_RS08285	COG1841	ribosomal large subunit assembly
I6K87_RS08290	COG0200	Binds to the 23S rRNA
I6K87_RS08295	COG0201	protein transport
I6K87_RS08300	COG0563	adenylate kinase activity
I6K87_RS08305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6K87_RS08310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6K87_RS08315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6K87_RS08320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6K87_RS08325	COG0202	RNA polymerase activity
I6K87_RS08330	COG0203	ribosomal protein L17
I6K87_RS08340	COG0052	Belongs to the universal ribosomal protein uS2 family
I6K87_RS08345	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6K87_RS08355	COG4463	regulation of RNA biosynthetic process
I6K87_RS08370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K87_RS08375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6K87_RS08405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6K87_RS08420	COG1396	sequence-specific DNA binding
I6K87_RS08430	COG0166	Belongs to the GPI family
I6K87_RS08440	COG0594	ribonuclease P activity
I6K87_RS08460	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6K87_RS08465	COG0084	hydrolase, TatD family'
I6K87_RS08485	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6K87_RS08500	COG1162	GTPase activity
I6K87_RS08510	COG1564	THIamine pyrophosphokinase
I6K87_RS08520	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6K87_RS08525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6K87_RS08535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6K87_RS08540	COG0049	tRNA binding
I6K87_RS08545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6K87_RS08565	COG1214	PFAM Peptidase M22, glycoprotease
I6K87_RS08590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K87_RS08595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6K87_RS08600	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6K87_RS08615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K87_RS08620	COG0681	Belongs to the peptidase S26 family
I6K87_RS08640	COG1193	negative regulation of DNA recombination
I6K87_RS08650	COG3118	belongs to the thioredoxin family
I6K87_RS08655	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6K87_RS08660	COG0668	transmembrane transport
I6K87_RS08670	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K87_RS08675	COG0167	dihydroorotate dehydrogenase activity
I6K87_RS08680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6K87_RS08680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6K87_RS08690	COG1940	carbohydrate kinase activity
I6K87_RS08695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K87_RS08705	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K87_RS08710	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K87_RS08720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K87_RS08720	COG2190	(PTS) system
I6K87_RS08720	COG1263	PTS System
I6K87_RS08750	COG0346	lactoylglutathione lyase activity
I6K87_RS08760	COG0561	phosphatase activity
I6K87_RS08780	COG1876	peptidase activity
I6K87_RS08785	COG0028	Belongs to the TPP enzyme family
I6K87_RS08790	COG1304	FMN binding
I6K87_RS08795	COG2723	6-phospho-beta-galactosidase activity
I6K87_RS08800	COG0745	RESPONSE REGULATOR receiver
I6K87_RS08805	COG5002	protein histidine kinase activity
I6K87_RS08815	COG1131	(ABC) transporter
I6K87_RS08830	COG1122	ATPase activity
I6K87_RS08840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6K87_RS08865	COG0588	phosphoglycerate mutase activity
I6K87_RS08890	COG0629	single-stranded DNA binding
I6K87_RS08895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K87_RS08910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K87_RS08920	COG0006	proline dipeptidase activity
I6K87_RS08925	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6K87_RS08975	COG1523	belongs to the glycosyl hydrolase 13 family
I6K87_RS08980	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6K87_RS08990	COG2176	DNA-directed DNA polymerase activity
I6K87_RS09040	COG3118	belongs to the thioredoxin family
I6K87_RS09055	COG1164	Oligoendopeptidase f
I6K87_RS09060	COG1185	polyribonucleotide nucleotidyltransferase activity
I6K87_RS09065	COG1045	serine acetyltransferase
I6K87_RS09075	COG0215	cysteine-tRNA ligase activity
I6K87_RS09080	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6K87_RS09090	COG3842	ATPase activity
I6K87_RS09100	COG3688	RNA-binding protein containing a PIN domain
I6K87_RS09110	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6K87_RS09115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6K87_RS09120	COG4974	Belongs to the 'phage' integrase family
I6K87_RS09140	COG3942	CHAP domain
I6K87_RS09140	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6K87_RS09155	COG0433	COG0433 Predicted ATPase
I6K87_RS09225	COG1674	ftsk spoiiie
I6K87_RS09255	COG1396	sequence-specific DNA binding
I6K87_RS09280	COG2226	methyltransferase
I6K87_RS09300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6K87_RS09355	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K87_RS09365	COG1215	transferase activity, transferring glycosyl groups
I6K87_RS09370	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K87_RS09390	COG3830	Belongs to the UPF0237 family
I6K87_RS09395	COG2848	UPF0210 protein
I6K87_RS09400	COG0588	phosphoglycerate mutase activity
I6K87_RS09405	COG0588	phosphoglycerate mutase activity
I6K87_RS09415	COG1420	regulation of RNA biosynthetic process
I6K87_RS09420	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6K87_RS09425	COG0443	Heat shock 70 kDa protein
I6K87_RS09430	COG0484	heat shock protein binding
I6K87_RS09440	COG0101	tRNA pseudouridine synthase activity
I6K87_RS09445	COG0351	phosphomethylpyrimidine kinase
I6K87_RS09450	COG4720	Psort location CytoplasmicMembrane, score
I6K87_RS09455	COG4475	Protein of unknown function (DUF436)
I6K87_RS09460	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6K87_RS09465	COG3343	RNA polymerase activity
I6K87_RS09470	COG0504	CTP synthase activity
I6K87_RS09480	COG4166	transmembrane transport
I6K87_RS09485	COG4166	transmembrane transport
I6K87_RS09490	COG0601	transmembrane transport
I6K87_RS09495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K87_RS09500	COG0444	Belongs to the ABC transporter superfamily
I6K87_RS09505	COG4608	Belongs to the ABC transporter superfamily
I6K87_RS09510	COG0561	phosphatase activity
I6K87_RS09515	COG1609	Transcriptional regulator
I6K87_RS09520	COG1621	beta-fructofuranosidase activity
I6K87_RS09525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K87_RS09525	COG2190	(PTS) system
I6K87_RS09525	COG1263	PTS System
I6K87_RS09530	COG1940	carbohydrate kinase activity
I6K87_RS09535	COG0242	peptide deformylase activity
I6K87_RS09550	COG1132	(ABC) transporter
I6K87_RS09555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K87_RS09560	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K87_RS09565	COG2723	6-phospho-beta-galactosidase activity
I6K87_RS09570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K87_RS09575	COG2188	Transcriptional regulator
I6K87_RS09580	COG1482	cell wall glycoprotein biosynthetic process
I6K87_RS09585	COG0531	amino acid
I6K87_RS09595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K87_RS09600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K87_RS09605	COG0736	holo-[acyl-carrier-protein] synthase activity
I6K87_RS09610	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K87_RS09615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K87_RS09620	COG0252	asparaginase activity
I6K87_RS09625	COG0561	phosphatase activity
I6K87_RS09630	COG0589	response to stress
I6K87_RS09635	COG0436	Aminotransferase
I6K87_RS09640	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6K87_RS09645	COG1335	isochorismatase
I6K87_RS09650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6K87_RS09655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K87_RS09660	COG0154	amidase activity
I6K87_RS09665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6K87_RS09680	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6K87_RS09685	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6K87_RS09690	COG1534	Rna-binding protein
I6K87_RS09695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6K87_RS09700	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6K87_RS09705	COG1335	isochorismatase
I6K87_RS09710	COG0799	negative regulation of ribosome biogenesis
I6K87_RS09715	COG2226	methyltransferase
I6K87_RS09725	COG1323	Belongs to the UPF0348 family
I6K87_RS09730	COG0217	transcriptional regulatory protein
I6K87_RS09735	COG1396	sequence-specific DNA binding
I6K87_RS09750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K87_RS09755	COG1464	Belongs to the NlpA lipoprotein family
I6K87_RS09760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K87_RS09765	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K87_RS09850	COG0640	Transcriptional regulator
I6K87_RS09875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate