locus-tag	class	description
SanJ4206_RS00010	COG0592	DNA-directed DNA polymerase activity
SanJ4206_RS00025	COG0012	GTP binding
SanJ4206_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
SanJ4206_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SanJ4206_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SanJ4206_RS00060	COG0037	tRNA processing
SanJ4206_RS00065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SanJ4206_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SanJ4206_RS00195	COG1792	Involved in formation and maintenance of cell shape
SanJ4206_RS00205	COG3942	CHAP domain
SanJ4206_RS00210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SanJ4206_RS00215	COG0436	Aminotransferase
SanJ4206_RS00220	COG1381	Involved in DNA repair and RecF pathway recombination
SanJ4206_RS00230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SanJ4206_RS00235	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SanJ4206_RS00240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SanJ4206_RS00250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SanJ4206_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SanJ4206_RS00270	COG3942	CHAP domain
SanJ4206_RS00305	COG0151	Belongs to the GarS family
SanJ4206_RS00310	COG1683	Conserved Protein
SanJ4206_RS00315	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SanJ4206_RS00340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SanJ4206_RS00345	COG2376	Dihydroxyacetone kinase
SanJ4206_RS00355	COG2376	Dihydroxyacetone kinase
SanJ4206_RS00360	COG1461	Dihydroxyacetone kinase
SanJ4206_RS00365	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SanJ4206_RS00370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SanJ4206_RS00390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SanJ4206_RS00400	COG3716	PTS system mannose fructose sorbose family IID component
SanJ4206_RS00410	COG2222	sugar isomerase
SanJ4206_RS00415	COG3684	Belongs to the aldolase LacD family
SanJ4206_RS00425	COG2255	four-way junction helicase activity
SanJ4206_RS00460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SanJ4206_RS00475	COG1454	alcohol dehydrogenase
SanJ4206_RS00475	COG1012	belongs to the aldehyde dehydrogenase family
SanJ4206_RS00480	COG1454	alcohol dehydrogenase
SanJ4206_RS00490	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SanJ4206_RS00500	COG1175	transmembrane transport
SanJ4206_RS00505	COG0395	ABC-type sugar transport system, permease component
SanJ4206_RS00510	COG2731	YhcH YjgK YiaL family protein
SanJ4206_RS00520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SanJ4206_RS00540	COG1269	ATP hydrolysis coupled proton transport
SanJ4206_RS00545	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SanJ4206_RS00555	COG1527	subunit (C
SanJ4206_RS00570	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SanJ4206_RS00575	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SanJ4206_RS00580	COG1394	ATPase activity, coupled to movement of substances
SanJ4206_RS00595	COG0131	Imidazoleglycerol-phosphate dehydratase
SanJ4206_RS00595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SanJ4206_RS00605	COG3759	membrane
SanJ4206_RS00610	COG1914	H( )-stimulated, divalent metal cation uptake system
SanJ4206_RS00635	COG1846	Transcriptional regulator
SanJ4206_RS00640	COG1121	(ABC) transporter
SanJ4206_RS00645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SanJ4206_RS00650	COG3443	Belongs to the bacterial solute-binding protein 9 family
SanJ4206_RS00650	COG0803	Belongs to the bacterial solute-binding protein 9 family
SanJ4206_RS00670	COG0564	pseudouridine synthase activity
SanJ4206_RS00675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SanJ4206_RS00680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SanJ4206_RS00835	COG0789	Transcriptional regulator
SanJ4206_RS00840	COG2081	HI0933 family
SanJ4206_RS00855	COG0584	glycerophosphoryl diester phosphodiesterase
SanJ4206_RS00860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SanJ4206_RS00870	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SanJ4206_RS00885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SanJ4206_RS00905	COG1304	FMN binding
SanJ4206_RS00915	COG3425	synthase
SanJ4206_RS00930	COG1882	Formate acetyltransferase
SanJ4206_RS00935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SanJ4206_RS00955	COG0756	dUTP diphosphatase activity
SanJ4206_RS00965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SanJ4206_RS00970	COG2171	N-acyltransferase activity
SanJ4206_RS00975	COG1473	amidohydrolase
SanJ4206_RS00980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SanJ4206_RS00990	COG2226	methyltransferase
SanJ4206_RS01000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SanJ4206_RS01010	COG0085	RNA polymerase activity
SanJ4206_RS01015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SanJ4206_RS01020	COG0126	phosphoglycerate kinase activity
SanJ4206_RS01025	COG3064	Membrane
SanJ4206_RS01025	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SanJ4206_RS01030	COG3942	CHAP domain
SanJ4206_RS01040	COG0789	Transcriptional regulator
SanJ4206_RS01045	COG0174	glutamine synthetase
SanJ4206_RS01055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SanJ4206_RS01060	COG1459	type II secretion system
SanJ4206_RS01065	COG4537	Required for transformation and DNA binding
SanJ4206_RS01095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SanJ4206_RS01110	COG3037	sugar-specific permease SgaT UlaA
SanJ4206_RS01120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SanJ4206_RS01130	COG3623	hexulose-6-phosphate isomerase
SanJ4206_RS01150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SanJ4206_RS01155	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
SanJ4206_RS01165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SanJ4206_RS01170	COG4589	Belongs to the CDS family
SanJ4206_RS01175	COG0750	zinc metalloprotease
SanJ4206_RS01180	COG0442	prolyl-tRNA aminoacylation
SanJ4206_RS01190	COG0285	dihydrofolate synthase activity
SanJ4206_RS01200	COG1363	Peptidase, m42
SanJ4206_RS01210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SanJ4206_RS01215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SanJ4206_RS01230	COG4585	Histidine kinase
SanJ4206_RS01235	COG2197	response regulator
SanJ4206_RS01255	COG3715	PTS system
SanJ4206_RS01260	COG3716	PTS system mannose fructose sorbose family IID component
SanJ4206_RS01270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SanJ4206_RS01275	COG0459	protein refolding
SanJ4206_RS01285	COG1428	Deoxynucleoside kinase
SanJ4206_RS01290	COG1418	mRNA catabolic process
SanJ4206_RS01310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SanJ4206_RS01320	COG1051	belongs to the nudix hydrolase family
SanJ4206_RS01330	COG2264	protein methyltransferase activity
SanJ4206_RS01335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SanJ4206_RS01345	COG1490	D-aminoacyl-tRNA deacylase activity
SanJ4206_RS01370	COG3590	peptidase
SanJ4206_RS01375	COG4988	ABC transporter
SanJ4206_RS01380	COG1132	(ABC) transporter
SanJ4206_RS01385	COG0495	leucyl-tRNA aminoacylation
SanJ4206_RS01415	COG0527	aspartate kinase activity
SanJ4206_RS01420	COG1024	Enoyl-CoA hydratase
SanJ4206_RS01430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SanJ4206_RS01440	COG2070	2-Nitropropane dioxygenase
SanJ4206_RS01445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SanJ4206_RS01450	COG1028	Short-chain dehydrogenase reductase Sdr
SanJ4206_RS01455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SanJ4206_RS01465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SanJ4206_RS01470	COG0439	Biotin carboxylase
SanJ4206_RS01475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SanJ4206_RS01480	COG0825	malonyl-CoA metabolic process
SanJ4206_RS01485	COG0586	Pfam SNARE associated Golgi protein
SanJ4206_RS01500	COG3716	PTS system mannose fructose sorbose family IID component
SanJ4206_RS01505	COG3715	PTS system
SanJ4206_RS01515	COG0561	phosphatase activity
SanJ4206_RS01525	COG2252	PERMEase
SanJ4206_RS01530	COG0802	atpase or kinase
SanJ4206_RS01540	COG1316	TRANSCRIPTIONal
SanJ4206_RS01550	COG0537	adenosine 5'-monophosphoramidase activity
SanJ4206_RS01555	COG1131	(ABC) transporter
SanJ4206_RS01565	COG0510	thiamine kinase activity
SanJ4206_RS01570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SanJ4206_RS01580	COG0779	Required for maturation of 30S ribosomal subunits
SanJ4206_RS01585	COG0195	Participates in both transcription termination and antitermination
SanJ4206_RS01590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SanJ4206_RS01605	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SanJ4206_RS01610	COG1283	sodium-dependent phosphate transmembrane transporter activity
SanJ4206_RS01625	COG0656	L-ascorbic acid biosynthetic process
SanJ4206_RS01645	COG0752	glycyl-tRNA synthetase alpha subunit
SanJ4206_RS01650	COG0751	glycine-tRNA ligase activity
SanJ4206_RS01665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SanJ4206_RS01675	COG0275	rRNA processing
SanJ4206_RS01685	COG0768	penicillin binding
SanJ4206_RS01690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SanJ4206_RS01700	COG4166	transmembrane transport
SanJ4206_RS01710	COG0191	fructose-bisphosphate aldolase activity
SanJ4206_RS01795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SanJ4206_RS01805	COG1461	Dihydroxyacetone kinase
SanJ4206_RS01810	COG1131	(ABC) transporter
SanJ4206_RS01820	COG4585	Histidine kinase
SanJ4206_RS01825	COG2197	response regulator
SanJ4206_RS01840	COG1126	abc transporter atp-binding protein
SanJ4206_RS01845	COG0765	amino acid transport
SanJ4206_RS01855	COG1968	undecaprenyl-diphosphatase activity
SanJ4206_RS01860	COG4862	establishment of competence for transformation
SanJ4206_RS01865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SanJ4206_RS01875	COG0719	Fe-S assembly protein
SanJ4206_RS01880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SanJ4206_RS01890	COG1686	Belongs to the peptidase S11 family
SanJ4206_RS01895	COG0513	Belongs to the DEAD box helicase family
SanJ4206_RS01905	COG1126	abc transporter atp-binding protein
SanJ4206_RS01915	COG0492	ferredoxin-NADP+ reductase activity
SanJ4206_RS01920	COG1113	amino acid transport
SanJ4206_RS01925	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SanJ4206_RS01930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SanJ4206_RS01935	COG3579	cysteine-type endopeptidase activity
SanJ4206_RS01940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SanJ4206_RS01945	COG3331	DNA recombination
SanJ4206_RS01950	COG4474	Belongs to the UPF0398 family
SanJ4206_RS01955	COG3599	regulation of cell shape
SanJ4206_RS01965	COG0116	Belongs to the methyltransferase superfamily
SanJ4206_RS01975	COG0450	alkyl hydroperoxide reductase
SanJ4206_RS01980	COG3634	alkyl hydroperoxide reductase activity
SanJ4206_RS01990	COG1418	mRNA catabolic process
SanJ4206_RS01995	COG0194	GDP metabolic process
SanJ4206_RS02000	COG1758	RNA polymerase activity
SanJ4206_RS02005	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SanJ4206_RS02010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SanJ4206_RS02015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SanJ4206_RS02015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SanJ4206_RS02020	COG0631	protein serine/threonine phosphatase activity
SanJ4206_RS02025	COG0515	serine threonine protein kinase
SanJ4206_RS02025	COG2815	serine threonine protein kinase
SanJ4206_RS02035	COG4585	Histidine kinase
SanJ4206_RS02050	COG1185	polyribonucleotide nucleotidyltransferase activity
SanJ4206_RS02060	COG3557	Belongs to the UPF0374 family
SanJ4206_RS02065	COG2137	regulation of response to DNA damage stimulus
SanJ4206_RS02070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SanJ4206_RS02080	COG2070	2-Nitropropane dioxygenase
SanJ4206_RS02100	COG0519	Catalyzes the synthesis of GMP from XMP
SanJ4206_RS02110	COG0525	valine-tRNA ligase activity
SanJ4206_RS02135	COG1739	Uncharacterized protein family UPF0029
SanJ4206_RS02140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SanJ4206_RS02145	COG1040	competence protein
SanJ4206_RS02155	COG0742	ribosomal rna small subunit methyltransferase
SanJ4206_RS02160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SanJ4206_RS02165	COG3480	Lon protease (S16) C-terminal proteolytic domain
SanJ4206_RS02170	COG4470	Protein conserved in bacteria
SanJ4206_RS02175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SanJ4206_RS02215	COG1187	pseudouridine synthase activity
SanJ4206_RS02220	COG1217	gtp-binding protein TYPA
SanJ4206_RS02230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SanJ4206_RS02235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SanJ4206_RS02240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SanJ4206_RS02250	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SanJ4206_RS02255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SanJ4206_RS02260	COG1799	cell septum assembly
SanJ4206_RS02275	COG3599	regulation of cell shape
SanJ4206_RS02280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SanJ4206_RS02285	COG1846	Transcriptional regulator
SanJ4206_RS02295	COG0628	permease
SanJ4206_RS02305	COG1253	flavin adenine dinucleotide binding
SanJ4206_RS02310	COG2188	Transcriptional regulator
SanJ4206_RS02315	COG1263	PTS System
SanJ4206_RS02315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SanJ4206_RS02320	COG0366	Alpha amylase catalytic
SanJ4206_RS02330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SanJ4206_RS02355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SanJ4206_RS02360	COG2244	polysaccharide biosynthetic process
SanJ4206_RS02365	COG0626	cystathionine gamma-synthase activity
SanJ4206_RS02370	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SanJ4206_RS02375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SanJ4206_RS02385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SanJ4206_RS02390	COG0740	serine-type endopeptidase activity
SanJ4206_RS02410	COG4177	L-phenylalanine transmembrane transporter activity
SanJ4206_RS02425	COG0517	IMP dehydrogenase activity
SanJ4206_RS02430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SanJ4206_RS02435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SanJ4206_RS02440	COG0470	DNA polymerase III
SanJ4206_RS02445	COG4467	Involved in initiation control of chromosome replication
SanJ4206_RS02455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SanJ4206_RS02460	COG1393	Belongs to the ArsC family
SanJ4206_RS02465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SanJ4206_RS02470	COG0708	Exodeoxyribonuclease III
SanJ4206_RS02480	COG0640	Transcriptional regulator
SanJ4206_RS02505	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SanJ4206_RS02505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SanJ4206_RS02515	COG0745	RESPONSE REGULATOR receiver
SanJ4206_RS02520	COG0642	Histidine kinase
SanJ4206_RS02530	COG1136	(ABC) transporter
SanJ4206_RS02535	COG0577	efflux transmembrane transporter activity
SanJ4206_RS02560	COG1136	(ABC) transporter
SanJ4206_RS02565	COG0577	efflux transmembrane transporter activity
SanJ4206_RS02570	COG0531	amino acid
SanJ4206_RS02605	COG0740	serine-type endopeptidase activity
SanJ4206_RS02655	COG3620	sequence-specific DNA binding
SanJ4206_RS02660	COG0582	viral genome integration into host DNA
SanJ4206_RS02670	COG1028	Short-chain dehydrogenase reductase Sdr
SanJ4206_RS02695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SanJ4206_RS02710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SanJ4206_RS02715	COG0488	(ABC) transporter
SanJ4206_RS02720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SanJ4206_RS02730	COG1983	PspC domain protein
SanJ4206_RS02735	COG1674	ftsk spoiiie
SanJ4206_RS02735	COG0697	spore germination
SanJ4206_RS02740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SanJ4206_RS02755	COG0081	regulation of translation
SanJ4206_RS02760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SanJ4206_RS02765	COG0372	Belongs to the citrate synthase family
SanJ4206_RS02770	COG0538	isocitrate dehydrogenase activity
SanJ4206_RS02775	COG0528	UMP kinase activity
SanJ4206_RS02780	COG0233	cytoplasmic translational termination
SanJ4206_RS02785	COG2996	Protein conserved in bacteria
SanJ4206_RS02790	COG1466	dna polymerase III delta subunit
SanJ4206_RS02795	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SanJ4206_RS02800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SanJ4206_RS02805	COG2274	protein secretion by the type I secretion system
SanJ4206_RS02840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SanJ4206_RS02845	COG0549	Belongs to the carbamate kinase family
SanJ4206_RS02850	COG1288	antiporter activity
SanJ4206_RS02855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SanJ4206_RS02865	COG1438	arginine binding
SanJ4206_RS02870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SanJ4206_RS02875	COG0363	glucosamine-6-phosphate deaminase activity
SanJ4206_RS02900	COG4122	O-methyltransferase activity
SanJ4206_RS02905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SanJ4206_RS02915	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SanJ4206_RS02925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SanJ4206_RS02945	COG2348	transferase activity, transferring amino-acyl groups
SanJ4206_RS02955	COG1078	dGTPase activity
SanJ4206_RS02990	COG0561	phosphatase activity
SanJ4206_RS03000	COG2884	Cell division ATP-binding protein ftsE
SanJ4206_RS03005	COG2177	Part of the ABC transporter FtsEX involved in
SanJ4206_RS03015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SanJ4206_RS03015	COG1199	ATP-dependent helicase activity
SanJ4206_RS03025	COG0772	Belongs to the SEDS family
SanJ4206_RS03040	COG0187	DNA topoisomerase II activity
SanJ4206_RS03045	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SanJ4206_RS03055	COG2706	6-phosphogluconolactonase activity
SanJ4206_RS03065	COG0745	RESPONSE REGULATOR receiver
SanJ4206_RS03070	COG3850	Histidine kinase
SanJ4206_RS03070	COG5002	protein histidine kinase activity
SanJ4206_RS03075	COG0628	permease
SanJ4206_RS03085	COG0028	Belongs to the TPP enzyme family
SanJ4206_RS03090	COG3527	Alpha-acetolactate decarboxylase
SanJ4206_RS03095	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SanJ4206_RS03110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SanJ4206_RS03120	COG4443	Transcriptional Coactivator p15 (PC4)
SanJ4206_RS03125	COG4152	abc transporter atp-binding protein
SanJ4206_RS03130	COG1668	transmembrane transport
SanJ4206_RS03135	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SanJ4206_RS03140	COG1074	ATP-dependent DNA helicase activity
SanJ4206_RS03185	COG0741	lytic transglycosylase activity
SanJ4206_RS03185	COG0791	NLP P60 protein
SanJ4206_RS03215	COG2946	Replication initiation factor
SanJ4206_RS03220	COG1674	ftsk spoiiie
SanJ4206_RS03235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SanJ4206_RS03240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SanJ4206_RS03245	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SanJ4206_RS03250	COG0297	glycogen (starch) synthase activity
SanJ4206_RS03255	COG0058	SHG alpha-glucan phosphorylase activity
SanJ4206_RS03265	COG0356	it plays a direct role in the translocation of protons across the membrane
SanJ4206_RS03270	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SanJ4206_RS03275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SanJ4206_RS03280	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SanJ4206_RS03285	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SanJ4206_RS03305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SanJ4206_RS03325	COG1132	(ABC) transporter
SanJ4206_RS03330	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SanJ4206_RS03350	COG1346	cytolysis
SanJ4206_RS03355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SanJ4206_RS03360	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SanJ4206_RS03370	COG2384	SAM-dependent methyltransferase
SanJ4206_RS03375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SanJ4206_RS03380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SanJ4206_RS03385	COG0494	nUDIX hydrolase
SanJ4206_RS03395	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SanJ4206_RS03405	COG1088	dTDP-glucose 4,6-dehydratase activity
SanJ4206_RS03410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SanJ4206_RS03420	COG0463	Glycosyl transferase, family 2
SanJ4206_RS03435	COG1091	dTDP-4-dehydrorhamnose reductase activity
SanJ4206_RS03445	COG1215	transferase activity, transferring glycosyl groups
SanJ4206_RS03450	COG1216	Glycosyl transferase, family 2
SanJ4206_RS03450	COG1442	glycosyl transferase family 8
SanJ4206_RS03455	COG0463	Glycosyl transferase, family 2
SanJ4206_RS03470	COG1442	glycosyl transferase family 8
SanJ4206_RS03470	COG1216	Glycosyl transferase, family 2
SanJ4206_RS03510	COG1368	sulfuric ester hydrolase activity
SanJ4206_RS03515	COG0006	proline dipeptidase activity
SanJ4206_RS03520	COG1609	Transcriptional regulator
SanJ4206_RS03530	COG0438	transferase activity, transferring glycosyl groups
SanJ4206_RS03540	COG0745	RESPONSE REGULATOR receiver
SanJ4206_RS03545	COG5002	protein histidine kinase activity
SanJ4206_RS03550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SanJ4206_RS03560	COG0571	ribonuclease III activity
SanJ4206_RS03565	COG1196	nuclear chromosome segregation
SanJ4206_RS03570	COG0561	phosphatase activity
SanJ4206_RS03575	COG0561	phosphatase activity
SanJ4206_RS03580	COG0552	protein localization to endoplasmic reticulum
SanJ4206_RS03585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SanJ4206_RS03590	COG0477	Major facilitator Superfamily
SanJ4206_RS03595	COG3689	TIGRFAM TIGR03943 family protein
SanJ4206_RS03600	COG0701	Predicted permease
SanJ4206_RS03630	COG2183	response to ionizing radiation
SanJ4206_RS03635	COG3091	SprT-like family
SanJ4206_RS03650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SanJ4206_RS03655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SanJ4206_RS03680	COG0826	peptidase U32
SanJ4206_RS03705	COG0488	(ABC) transporter
SanJ4206_RS03715	COG3442	glutamine amidotransferase
SanJ4206_RS03720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SanJ4206_RS03725	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SanJ4206_RS03735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SanJ4206_RS03740	COG0560	Phosphoserine phosphatase
SanJ4206_RS03765	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SanJ4206_RS03775	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SanJ4206_RS03785	COG0346	lactoylglutathione lyase activity
SanJ4206_RS03790	COG0726	polysaccharide deacetylase
SanJ4206_RS03800	COG0673	inositol 2-dehydrogenase activity
SanJ4206_RS03805	COG0572	uridine kinase
SanJ4206_RS03815	COG2195	Cleaves the N-terminal amino acid of tripeptides
SanJ4206_RS03820	COG0561	phosphatase activity
SanJ4206_RS03825	COG0481	GTPase activity
SanJ4206_RS03835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SanJ4206_RS03840	COG3842	ATPase activity
SanJ4206_RS03845	COG1176	ABC-type spermidine putrescine transport system, permease component I
SanJ4206_RS03850	COG1177	transmembrane transport
SanJ4206_RS03865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SanJ4206_RS03865	COG0574	Belongs to the PEP-utilizing enzyme family
SanJ4206_RS03870	COG0517	IMP dehydrogenase activity
SanJ4206_RS03875	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SanJ4206_RS03880	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SanJ4206_RS03885	COG1104	cysteine desulfurase activity
SanJ4206_RS03890	COG0301	tRNA thio-modification
SanJ4206_RS03895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SanJ4206_RS03905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SanJ4206_RS03915	COG0425	Belongs to the sulfur carrier protein TusA family
SanJ4206_RS03915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SanJ4206_RS03920	COG0446	pyridine nucleotide-disulphide oxidoreductase
SanJ4206_RS03925	COG1054	Belongs to the UPF0176 family
SanJ4206_RS03935	COG1937	Protein conserved in bacteria
SanJ4206_RS03940	COG0583	DNA-binding transcription factor activity
SanJ4206_RS03950	COG0564	pseudouridine synthase activity
SanJ4206_RS03955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SanJ4206_RS03960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SanJ4206_RS03965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SanJ4206_RS03970	COG2824	Alkylphosphonate utilization operon protein PhnA
SanJ4206_RS03995	COG0038	chloride channel
SanJ4206_RS04000	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SanJ4206_RS04005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SanJ4206_RS04020	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SanJ4206_RS04025	COG1705	Flagellar rod assembly protein muramidase FlgJ
SanJ4206_RS04025	COG1388	LysM domain
SanJ4206_RS04035	COG1132	(ABC) transporter
SanJ4206_RS04040	COG0488	(ABC) transporter
SanJ4206_RS04060	COG0556	nucleotide-excision repair
SanJ4206_RS04075	COG1131	(ABC) transporter
SanJ4206_RS04085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SanJ4206_RS04095	COG0647	UMP catabolic process
SanJ4206_RS04115	COG1660	Displays ATPase and GTPase activities
SanJ4206_RS04120	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SanJ4206_RS04125	COG1481	regulation of sporulation
SanJ4206_RS04130	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SanJ4206_RS04140	COG0540	Belongs to the ATCase OTCase family
SanJ4206_RS04145	COG0505	Belongs to the CarA family
SanJ4206_RS04150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SanJ4206_RS04155	COG2814	Major facilitator Superfamily
SanJ4206_RS04160	COG0583	DNA-binding transcription factor activity
SanJ4206_RS04180	COG0543	2 iron, 2 sulfur cluster binding
SanJ4206_RS04185	COG0167	dihydroorotate dehydrogenase activity
SanJ4206_RS04190	COG0284	orotidine-5'-phosphate decarboxylase activity
SanJ4206_RS04200	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SanJ4206_RS04215	COG4479	Belongs to the UPF0346 family
SanJ4206_RS04220	COG1702	phosphate starvation-inducible protein PhoH
SanJ4206_RS04240	COG0686	Belongs to the AlaDH PNT family
SanJ4206_RS04245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SanJ4206_RS04265	COG1132	(ABC) transporter
SanJ4206_RS04270	COG1132	(ABC) transporter
SanJ4206_RS04275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SanJ4206_RS04280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SanJ4206_RS04285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SanJ4206_RS04310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SanJ4206_RS04315	COG0237	dephospho-CoA kinase activity
SanJ4206_RS04320	COG2814	Major facilitator Superfamily
SanJ4206_RS04325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SanJ4206_RS04335	COG0557	exoribonuclease II activity
SanJ4206_RS04350	COG0658	competence protein
SanJ4206_RS04350	COG2333	competence protein COMEC
SanJ4206_RS04365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SanJ4206_RS04370	COG1051	belongs to the nudix hydrolase family
SanJ4206_RS04375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SanJ4206_RS04380	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SanJ4206_RS04385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SanJ4206_RS04395	COG4109	DRTGG domain
SanJ4206_RS04400	COG0024	Methionine aminopeptidase
SanJ4206_RS04410	COG1846	Transcriptional regulator
SanJ4206_RS04420	COG2246	polysaccharide biosynthetic process
SanJ4206_RS04425	COG4708	membrane
SanJ4206_RS04435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SanJ4206_RS04440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SanJ4206_RS04445	COG1597	lipid kinase activity
SanJ4206_RS04450	COG1523	belongs to the glycosyl hydrolase 13 family
SanJ4206_RS04455	COG0228	four-way junction DNA binding
SanJ4206_RS04460	COG1837	Belongs to the UPF0109 family
SanJ4206_RS04465	COG1827	regulation of RNA biosynthetic process
SanJ4206_RS04480	COG3142	Participates in the control of copper homeostasis
SanJ4206_RS04485	COG2315	Protein conserved in bacteria
SanJ4206_RS04490	COG1132	(ABC) transporter
SanJ4206_RS04495	COG1132	(ABC) transporter
SanJ4206_RS04500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SanJ4206_RS04515	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SanJ4206_RS04520	COG1970	mechanosensitive ion channel activity
SanJ4206_RS04525	COG0358	DNA primase activity
SanJ4206_RS04530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SanJ4206_RS04535	COG2151	metal-sulfur cluster biosynthetic enzyme
SanJ4206_RS04540	COG1114	Component of the transport system for branched-chain amino acids
SanJ4206_RS04545	COG0785	Cytochrome C biogenesis protein
SanJ4206_RS04550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SanJ4206_RS04555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SanJ4206_RS04555	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SanJ4206_RS04560	COG2197	response regulator
SanJ4206_RS04565	COG2972	Histidine kinase
SanJ4206_RS04580	COG4555	ABC transporter
SanJ4206_RS04585	COG0431	NADPH-dependent FMN reductase
SanJ4206_RS04585	COG1053	succinate dehydrogenase
SanJ4206_RS04585	COG3976	FMN-binding domain protein
SanJ4206_RS04605	COG0038	chloride channel
SanJ4206_RS04615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SanJ4206_RS04620	COG2233	PERMEase
SanJ4206_RS04625	COG0534	Mate efflux family protein
SanJ4206_RS04630	COG1942	4-Oxalocrotonate Tautomerase
SanJ4206_RS04635	COG1435	thymidine kinase activity
SanJ4206_RS04645	COG2890	protein-(glutamine-N5) methyltransferase activity
SanJ4206_RS04655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SanJ4206_RS04665	COG0741	lytic transglycosylase activity
SanJ4206_RS04690	COG2188	Transcriptional regulator
SanJ4206_RS04700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SanJ4206_RS04705	COG4974	Belongs to the 'phage' integrase family
SanJ4206_RS04710	COG0095	Lipoate-protein ligase
SanJ4206_RS04715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SanJ4206_RS04720	COG0508	dehydrogenase complex catalyzes the overall conversion of
SanJ4206_RS04725	COG0022	dehydrogenase e1 component
SanJ4206_RS04730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SanJ4206_RS04750	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SanJ4206_RS04755	COG0135	phosphoribosylanthranilate isomerase activity
SanJ4206_RS04760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SanJ4206_RS04765	COG0758	DNA mediated transformation
SanJ4206_RS04770	COG0110	maltose O-acetyltransferase activity
SanJ4206_RS04775	COG3711	transcriptional antiterminator
SanJ4206_RS04780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SanJ4206_RS04785	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SanJ4206_RS04790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SanJ4206_RS04795	COG1960	acyl-CoA dehydrogenase activity
SanJ4206_RS04800	COG0583	DNA-binding transcription factor activity
SanJ4206_RS04805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SanJ4206_RS04815	COG1024	Enoyl-CoA hydratase
SanJ4206_RS04820	COG0183	Belongs to the thiolase family
SanJ4206_RS04825	COG1250	3-hydroxyacyl-CoA dehydrogenase
SanJ4206_RS04830	COG1960	acyl-CoA dehydrogenase activity
SanJ4206_RS04835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SanJ4206_RS04840	COG3764	Sortase (surface protein transpeptidase)
SanJ4206_RS04845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SanJ4206_RS04850	COG0039	L-malate dehydrogenase activity
SanJ4206_RS04865	COG0539	negative regulation of cytoplasmic translation
SanJ4206_RS04885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SanJ4206_RS04890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SanJ4206_RS04910	COG0187	DNA topoisomerase II activity
SanJ4206_RS04915	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SanJ4206_RS04920	COG0737	Belongs to the 5'-nucleotidase family
SanJ4206_RS04930	COG2131	deaminase
SanJ4206_RS04935	COG1309	transcriptional regulator
SanJ4206_RS04980	COG2814	Major facilitator Superfamily
SanJ4206_RS04985	COG0017	Asparaginyl-tRNA synthetase
SanJ4206_RS04995	COG0436	Aminotransferase
SanJ4206_RS05005	COG1846	Transcriptional regulator
SanJ4206_RS05015	COG3022	response to hydroperoxide
SanJ4206_RS05025	COG1272	protein, Hemolysin III
SanJ4206_RS05030	COG1079	Belongs to the binding-protein-dependent transport system permease family
SanJ4206_RS05035	COG4603	Belongs to the binding-protein-dependent transport system permease family
SanJ4206_RS05040	COG3845	ABC transporter
SanJ4206_RS05045	COG1744	ABC transporter substrate-binding protein PnrA-like
SanJ4206_RS05050	COG0295	cytidine deaminase activity
SanJ4206_RS05055	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SanJ4206_RS05065	COG2813	Specifically methylates the guanine in position
SanJ4206_RS05070	COG1072	(Pantothenic acid kinase))
SanJ4206_RS05075	COG0268	Binds directly to 16S ribosomal RNA
SanJ4206_RS05085	COG4187	Peptidase family M20/M25/M40
SanJ4206_RS05095	COG5002	protein histidine kinase activity
SanJ4206_RS05100	COG0745	RESPONSE REGULATOR receiver
SanJ4206_RS05150	COG1674	ftsk spoiiie
SanJ4206_RS05185	COG1940	carbohydrate kinase activity
SanJ4206_RS05220	COG0083	homoserine kinase activity
SanJ4206_RS05230	COG0726	polysaccharide deacetylase
SanJ4206_RS05240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SanJ4206_RS05250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SanJ4206_RS05250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SanJ4206_RS05260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SanJ4206_RS05265	COG1609	Transcriptional regulator
SanJ4206_RS05270	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SanJ4206_RS05270	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SanJ4206_RS05280	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SanJ4206_RS05285	COG1956	GAF domain-containing protein
SanJ4206_RS05295	COG3443	Belongs to the bacterial solute-binding protein 9 family
SanJ4206_RS05295	COG0803	Belongs to the bacterial solute-binding protein 9 family
SanJ4206_RS05300	COG0336	Belongs to the RNA methyltransferase TrmD family
SanJ4206_RS05305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SanJ4206_RS05320	COG0222	ribosome binding
SanJ4206_RS05325	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SanJ4206_RS05330	COG2207	Transcriptional regulator
SanJ4206_RS05330	COG3708	Transcriptional regulator
SanJ4206_RS05345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SanJ4206_RS05350	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SanJ4206_RS05370	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SanJ4206_RS05380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SanJ4206_RS05385	COG4684	Psort location CytoplasmicMembrane, score
SanJ4206_RS05390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SanJ4206_RS05405	COG0280	phosphate acetyltransferase
SanJ4206_RS05410	COG0564	pseudouridine synthase activity
SanJ4206_RS05420	COG2357	RelA SpoT domain protein
SanJ4206_RS05430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SanJ4206_RS05435	COG1104	cysteine desulfurase activity
SanJ4206_RS05450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SanJ4206_RS05455	COG2003	Belongs to the UPF0758 family
SanJ4206_RS05460	COG0704	Plays a role in the regulation of phosphate uptake
SanJ4206_RS05465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SanJ4206_RS05470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SanJ4206_RS05475	COG0581	inorganic phosphate transmembrane transporter activity
SanJ4206_RS05480	COG0573	inorganic phosphate transmembrane transporter activity
SanJ4206_RS05490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SanJ4206_RS05490	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SanJ4206_RS05495	COG0483	inositol monophosphate 1-phosphatase activity
SanJ4206_RS05500	COG4476	Belongs to the UPF0223 family
SanJ4206_RS05505	COG1393	Belongs to the ArsC family
SanJ4206_RS05510	COG0196	riboflavin kinase activity
SanJ4206_RS05515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SanJ4206_RS05525	COG1132	(ABC) transporter
SanJ4206_RS05530	COG1132	(ABC) transporter
SanJ4206_RS05530	COG2375	cellular response to nickel ion
SanJ4206_RS05535	COG2378	regulation of single-species biofilm formation
SanJ4206_RS05540	COG1051	belongs to the nudix hydrolase family
SanJ4206_RS05545	COG0210	DNA helicase
SanJ4206_RS05550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SanJ4206_RS05560	COG1126	abc transporter atp-binding protein
SanJ4206_RS05565	COG0765	amino acid transport
SanJ4206_RS05575	COG0469	pyruvate kinase activity
SanJ4206_RS05580	COG0205	6-phosphofructokinase activity
SanJ4206_RS05590	COG1725	Transcriptional regulator
SanJ4206_RS05595	COG1131	(ABC) transporter
SanJ4206_RS05605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SanJ4206_RS05605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SanJ4206_RS05620	COG0300	oxidoreductase activity
SanJ4206_RS05640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SanJ4206_RS05645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SanJ4206_RS05655	COG0577	efflux transmembrane transporter activity
SanJ4206_RS05660	COG1136	(ABC) transporter
SanJ4206_RS05670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SanJ4206_RS05675	COG1268	BioY protein
SanJ4206_RS05690	COG0072	phenylalanine-tRNA ligase activity
SanJ4206_RS05690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SanJ4206_RS05705	COG0488	(ABC) transporter
SanJ4206_RS05710	COG0617	tRNA 3'-terminal CCA addition
SanJ4206_RS05715	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SanJ4206_RS05720	COG1307	EDD domain protein, DegV family
SanJ4206_RS05730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SanJ4206_RS05730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SanJ4206_RS05730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SanJ4206_RS05735	COG1105	Belongs to the carbohydrate kinase PfkB family
SanJ4206_RS05740	COG1349	DNA-binding transcription factor activity
SanJ4206_RS05750	COG0492	ferredoxin-NADP+ reductase activity
SanJ4206_RS05755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SanJ4206_RS05785	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SanJ4206_RS05800	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SanJ4206_RS05850	COG2378	regulation of single-species biofilm formation
SanJ4206_RS05880	COG3421	Type III restriction
SanJ4206_RS05885	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SanJ4206_RS05910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SanJ4206_RS05910	COG0551	DNA topoisomerase type I activity
SanJ4206_RS06000	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SanJ4206_RS06040	COG1132	(ABC) transporter
SanJ4206_RS06045	COG1132	(ABC) transporter
SanJ4206_RS06050	COG4977	sequence-specific DNA binding
SanJ4206_RS06050	COG1917	Cupin 2, conserved barrel domain protein
SanJ4206_RS06070	COG0464	growth
SanJ4206_RS06090	COG0551	DNA topoisomerase type I activity
SanJ4206_RS06090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SanJ4206_RS06185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SanJ4206_RS06200	COG1484	DNA-dependent DNA replication
SanJ4206_RS06220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SanJ4206_RS06230	COG0077	Prephenate dehydratase
SanJ4206_RS06235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SanJ4206_RS06240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SanJ4206_RS06250	COG3679	Belongs to the UPF0342 family
SanJ4206_RS06255	COG0287	Prephenate dehydrogenase
SanJ4206_RS06265	COG0730	response to heat
SanJ4206_RS06270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SanJ4206_RS06275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SanJ4206_RS06280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SanJ4206_RS06285	COG0710	3-dehydroquinate dehydratase activity
SanJ4206_RS06290	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SanJ4206_RS06295	COG1368	sulfuric ester hydrolase activity
SanJ4206_RS06305	COG0813	purine-nucleoside phosphorylase activity
SanJ4206_RS06320	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SanJ4206_RS06335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SanJ4206_RS06355	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SanJ4206_RS06360	COG0772	Belongs to the SEDS family
SanJ4206_RS06375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SanJ4206_RS06380	COG0406	alpha-ribazole phosphatase activity
SanJ4206_RS06385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SanJ4206_RS06410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SanJ4206_RS06410	COG0456	acetyltransferase
SanJ4206_RS06425	COG1882	Formate acetyltransferase
SanJ4206_RS06430	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SanJ4206_RS06440	COG1447	Phosphotransferase system cellobiose-specific component IIA
SanJ4206_RS06450	COG1349	DNA-binding transcription factor activity
SanJ4206_RS06455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SanJ4206_RS06465	COG1959	2 iron, 2 sulfur cluster binding
SanJ4206_RS06480	COG1136	(ABC) transporter
SanJ4206_RS06485	COG1309	transcriptional regulator
SanJ4206_RS06510	COG1518	maintenance of DNA repeat elements
SanJ4206_RS06515	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SanJ4206_RS06525	COG0716	FMN binding
SanJ4206_RS06530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SanJ4206_RS06535	COG0254	rRNA binding
SanJ4206_RS06560	COG1125	glycine betaine transport
SanJ4206_RS06565	COG1732	Glycine betaine
SanJ4206_RS06575	COG1573	uracil-dna glycosylase
SanJ4206_RS06585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SanJ4206_RS06595	COG0322	excinuclease ABC activity
SanJ4206_RS06600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SanJ4206_RS06610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SanJ4206_RS06620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SanJ4206_RS06635	COG1476	TRANSCRIPTIONal
SanJ4206_RS06650	COG0204	Acyl-transferase
SanJ4206_RS06655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SanJ4206_RS06660	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SanJ4206_RS06665	COG2827	Endonuclease containing a URI domain
SanJ4206_RS06675	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SanJ4206_RS06675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SanJ4206_RS06680	COG1447	Phosphotransferase system cellobiose-specific component IIA
SanJ4206_RS06690	COG3711	transcriptional antiterminator
SanJ4206_RS06695	COG1755	Isoprenylcysteine carboxyl methyltransferase
SanJ4206_RS06705	COG3775	system Galactitol-specific IIC component
SanJ4206_RS06725	COG0698	ribose 5-phosphate isomerase
SanJ4206_RS06730	COG1349	DNA-binding transcription factor activity
SanJ4206_RS06740	COG0513	Belongs to the DEAD box helicase family
SanJ4206_RS06765	COG3620	sequence-specific DNA binding
SanJ4206_RS06810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SanJ4206_RS06815	COG1181	Belongs to the D-alanine--D-alanine ligase family
SanJ4206_RS06820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SanJ4206_RS06825	COG0768	penicillin binding
SanJ4206_RS06830	COG0588	phosphoglycerate mutase activity
SanJ4206_RS06845	COG1307	EDD domain protein, DegV family
SanJ4206_RS06850	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SanJ4206_RS06865	COG4605	iron ion homeostasis
SanJ4206_RS06870	COG4604	ABC transporter, ATP-binding protein
SanJ4206_RS06875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SanJ4206_RS06880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SanJ4206_RS06885	COG0497	DNA recombination
SanJ4206_RS06890	COG1438	arginine binding
SanJ4206_RS06895	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SanJ4206_RS06905	COG1722	exodeoxyribonuclease VII activity
SanJ4206_RS06910	COG1570	exodeoxyribonuclease VII activity
SanJ4206_RS06920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SanJ4206_RS06925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SanJ4206_RS06930	COG0577	efflux transmembrane transporter activity
SanJ4206_RS06935	COG1136	(ABC) transporter
SanJ4206_RS06960	COG4703	Protein of unknown function (DUF1797)
SanJ4206_RS06965	COG0542	response to heat
SanJ4206_RS06980	COG0494	nUDIX hydrolase
SanJ4206_RS06990	COG0025	NhaP-type Na H and K H
SanJ4206_RS07000	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SanJ4206_RS07005	COG1242	4 iron, 4 sulfur cluster binding
SanJ4206_RS07015	COG0671	phosphoesterase, PA-phosphatase related
SanJ4206_RS07020	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SanJ4206_RS07030	COG0569	domain protein
SanJ4206_RS07035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SanJ4206_RS07050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SanJ4206_RS07055	COG1187	pseudouridine synthase activity
SanJ4206_RS07060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SanJ4206_RS07065	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SanJ4206_RS07070	COG4974	Belongs to the 'phage' integrase family
SanJ4206_RS07085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SanJ4206_RS07090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SanJ4206_RS07115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SanJ4206_RS07120	COG1254	Belongs to the acylphosphatase family
SanJ4206_RS07145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SanJ4206_RS07160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SanJ4206_RS07170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SanJ4206_RS07180	COG1160	GTP binding
SanJ4206_RS07190	COG1484	DNA-dependent DNA replication
SanJ4206_RS07200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SanJ4206_RS07215	COG2190	(PTS) system
SanJ4206_RS07215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SanJ4206_RS07215	COG1263	PTS System
SanJ4206_RS07220	COG0745	RESPONSE REGULATOR receiver
SanJ4206_RS07225	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SanJ4206_RS07230	COG1309	transcriptional regulator
SanJ4206_RS07235	COG1131	(ABC) transporter
SanJ4206_RS07265	COG0501	Belongs to the peptidase M48B family
SanJ4206_RS07270	COG1704	LemA family
SanJ4206_RS07275	COG0357	Ribosomal RNA small subunit methyltransferase G
SanJ4206_RS07280	COG1442	glycosyl transferase family 8
SanJ4206_RS07285	COG4221	oxidoreductase activity
SanJ4206_RS07295	COG1122	ATPase activity
SanJ4206_RS07325	COG4720	Psort location CytoplasmicMembrane, score
SanJ4206_RS07420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SanJ4206_RS07425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SanJ4206_RS07430	COG1464	Belongs to the NlpA lipoprotein family
SanJ4206_RS07435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SanJ4206_RS07445	COG1396	sequence-specific DNA binding
SanJ4206_RS07455	COG1323	Belongs to the UPF0348 family
SanJ4206_RS07465	COG2226	methyltransferase
SanJ4206_RS07470	COG0799	negative regulation of ribosome biogenesis
SanJ4206_RS07475	COG1335	isochorismatase
SanJ4206_RS07480	COG1713	HD superfamily hydrolase involved in NAD metabolism
SanJ4206_RS07485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SanJ4206_RS07490	COG1534	Rna-binding protein
SanJ4206_RS07495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SanJ4206_RS07500	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SanJ4206_RS07515	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SanJ4206_RS07520	COG0154	amidase activity
SanJ4206_RS07525	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SanJ4206_RS07530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SanJ4206_RS07535	COG1335	isochorismatase
SanJ4206_RS07540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SanJ4206_RS07545	COG0436	Aminotransferase
SanJ4206_RS07550	COG0589	response to stress
SanJ4206_RS07560	COG0561	phosphatase activity
SanJ4206_RS07565	COG0252	asparaginase activity
SanJ4206_RS07570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SanJ4206_RS07575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SanJ4206_RS07580	COG0736	holo-[acyl-carrier-protein] synthase activity
SanJ4206_RS07585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SanJ4206_RS07590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SanJ4206_RS07600	COG0531	amino acid
SanJ4206_RS07605	COG1482	cell wall glycoprotein biosynthetic process
SanJ4206_RS07610	COG2188	Transcriptional regulator
SanJ4206_RS07615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SanJ4206_RS07620	COG2723	6-phospho-beta-galactosidase activity
SanJ4206_RS07625	COG1447	Phosphotransferase system cellobiose-specific component IIA
SanJ4206_RS07630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SanJ4206_RS07635	COG1132	(ABC) transporter
SanJ4206_RS07650	COG0242	peptide deformylase activity
SanJ4206_RS07655	COG1940	carbohydrate kinase activity
SanJ4206_RS07660	COG1263	PTS System
SanJ4206_RS07660	COG2190	(PTS) system
SanJ4206_RS07660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SanJ4206_RS07665	COG1621	beta-fructofuranosidase activity
SanJ4206_RS07670	COG1609	Transcriptional regulator
SanJ4206_RS07680	COG4608	Belongs to the ABC transporter superfamily
SanJ4206_RS07685	COG0444	Belongs to the ABC transporter superfamily
SanJ4206_RS07690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SanJ4206_RS07695	COG0601	transmembrane transport
SanJ4206_RS07700	COG4166	transmembrane transport
SanJ4206_RS07705	COG4166	transmembrane transport
SanJ4206_RS07715	COG0504	CTP synthase activity
SanJ4206_RS07725	COG0544	peptidyl-prolyl cis-trans isomerase activity
SanJ4206_RS07730	COG4475	Protein of unknown function (DUF436)
SanJ4206_RS07735	COG4720	Psort location CytoplasmicMembrane, score
SanJ4206_RS07740	COG0351	phosphomethylpyrimidine kinase
SanJ4206_RS07745	COG0101	tRNA pseudouridine synthase activity
SanJ4206_RS07755	COG0484	heat shock protein binding
SanJ4206_RS07765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SanJ4206_RS07770	COG1420	regulation of RNA biosynthetic process
SanJ4206_RS07775	COG0588	phosphoglycerate mutase activity
SanJ4206_RS07780	COG0588	phosphoglycerate mutase activity
SanJ4206_RS07785	COG2848	UPF0210 protein
SanJ4206_RS07790	COG3830	Belongs to the UPF0237 family
SanJ4206_RS07855	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SanJ4206_RS07915	COG4974	Belongs to the 'phage' integrase family
SanJ4206_RS07920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SanJ4206_RS07925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SanJ4206_RS07935	COG3688	RNA-binding protein containing a PIN domain
SanJ4206_RS07945	COG3842	ATPase activity
SanJ4206_RS07955	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SanJ4206_RS07960	COG0215	cysteine-tRNA ligase activity
SanJ4206_RS07970	COG1045	serine acetyltransferase
SanJ4206_RS07975	COG1185	polyribonucleotide nucleotidyltransferase activity
SanJ4206_RS07980	COG1164	Oligoendopeptidase f
SanJ4206_RS08010	COG3344	reverse transcriptase
SanJ4206_RS08035	COG2801	Transposase and inactivated derivatives
SanJ4206_RS08045	COG1187	pseudouridine synthase activity
SanJ4206_RS08115	COG2176	DNA-directed DNA polymerase activity
SanJ4206_RS08125	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SanJ4206_RS08145	COG1609	Transcriptional regulator
SanJ4206_RS08170	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SanJ4206_RS08175	COG0006	proline dipeptidase activity
SanJ4206_RS08185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SanJ4206_RS08200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SanJ4206_RS08205	COG0629	single-stranded DNA binding
SanJ4206_RS08230	COG0588	phosphoglycerate mutase activity
SanJ4206_RS08235	COG0588	phosphoglycerate mutase activity
SanJ4206_RS08255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SanJ4206_RS08265	COG1122	ATPase activity
SanJ4206_RS08290	COG5002	protein histidine kinase activity
SanJ4206_RS08295	COG0745	RESPONSE REGULATOR receiver
SanJ4206_RS08300	COG2723	6-phospho-beta-galactosidase activity
SanJ4206_RS08305	COG1304	FMN binding
SanJ4206_RS08310	COG0028	Belongs to the TPP enzyme family
SanJ4206_RS08315	COG1876	peptidase activity
SanJ4206_RS08335	COG0561	phosphatase activity
SanJ4206_RS08345	COG0346	lactoylglutathione lyase activity
SanJ4206_RS08375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SanJ4206_RS08375	COG1263	PTS System
SanJ4206_RS08375	COG2190	(PTS) system
SanJ4206_RS08385	COG1447	Phosphotransferase system cellobiose-specific component IIA
SanJ4206_RS08390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SanJ4206_RS08400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SanJ4206_RS08405	COG1940	carbohydrate kinase activity
SanJ4206_RS08415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SanJ4206_RS08415	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SanJ4206_RS08420	COG0167	dihydroorotate dehydrogenase activity
SanJ4206_RS08425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SanJ4206_RS08435	COG0668	transmembrane transport
SanJ4206_RS08440	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SanJ4206_RS08445	COG3118	belongs to the thioredoxin family
SanJ4206_RS08455	COG1193	negative regulation of DNA recombination
SanJ4206_RS08475	COG0681	Belongs to the peptidase S26 family
SanJ4206_RS08485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SanJ4206_RS08500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SanJ4206_RS08510	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SanJ4206_RS08515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SanJ4206_RS08530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SanJ4206_RS08540	COG1214	PFAM Peptidase M22, glycoprotease
SanJ4206_RS08560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SanJ4206_RS08565	COG0049	tRNA binding
SanJ4206_RS08570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SanJ4206_RS08585	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SanJ4206_RS08590	COG3481	metal-dependent phosphohydrolase, HD sub domain
SanJ4206_RS08600	COG1564	THIamine pyrophosphokinase
SanJ4206_RS08610	COG1162	GTPase activity
SanJ4206_RS08625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SanJ4206_RS08645	COG0084	hydrolase, TatD family'
SanJ4206_RS08650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SanJ4206_RS08670	COG0594	ribonuclease P activity
SanJ4206_RS08680	COG0166	Belongs to the GPI family
SanJ4206_RS08690	COG1396	sequence-specific DNA binding
SanJ4206_RS08705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SanJ4206_RS08735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SanJ4206_RS08740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SanJ4206_RS08755	COG4463	regulation of RNA biosynthetic process
SanJ4206_RS08770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SanJ4206_RS08775	COG0052	Belongs to the universal ribosomal protein uS2 family
SanJ4206_RS08790	COG0203	ribosomal protein L17
SanJ4206_RS08795	COG0202	RNA polymerase activity
SanJ4206_RS08800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SanJ4206_RS08805	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SanJ4206_RS08810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SanJ4206_RS08815	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SanJ4206_RS08820	COG0563	adenylate kinase activity
SanJ4206_RS08825	COG0201	protein transport
SanJ4206_RS08830	COG0200	Binds to the 23S rRNA
SanJ4206_RS08835	COG1841	ribosomal large subunit assembly
SanJ4206_RS08840	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SanJ4206_RS08850	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SanJ4206_RS08855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SanJ4206_RS08860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SanJ4206_RS08865	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SanJ4206_RS08870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SanJ4206_RS08875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SanJ4206_RS08885	COG0255	Belongs to the universal ribosomal protein uL29 family
SanJ4206_RS08890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SanJ4206_RS08895	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SanJ4206_RS08900	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SanJ4206_RS08910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SanJ4206_RS08915	COG0089	rRNA binding
SanJ4206_RS08920	COG0088	Forms part of the polypeptide exit tunnel
SanJ4206_RS08925	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SanJ4206_RS08930	COG0051	transcription antitermination factor activity, RNA binding
SanJ4206_RS08935	COG0343	queuine tRNA-ribosyltransferase activity
SanJ4206_RS08950	COG0572	uridine kinase
SanJ4206_RS08955	COG1832	CoA-binding protein
SanJ4206_RS09000	COG1832	CoA-binding protein
SanJ4206_RS09005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SanJ4206_RS09005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SanJ4206_RS09015	COG5002	protein histidine kinase activity
SanJ4206_RS09050	COG2801	Transposase and inactivated derivatives
SanJ4206_RS09055	COG4750	Nucleotidyl transferase
SanJ4206_RS09080	COG3475	LICD family
SanJ4206_RS09100	COG0438	transferase activity, transferring glycosyl groups
SanJ4206_RS09130	COG3944	biosynthesis protein
SanJ4206_RS09135	COG4464	protein tyrosine phosphatase activity
SanJ4206_RS09145	COG0602	queuosine metabolic process
SanJ4206_RS09175	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SanJ4206_RS09185	COG0285	dihydrofolate synthase activity
SanJ4206_RS09190	COG3906	Belongs to the UPF0473 family
SanJ4206_RS09195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SanJ4206_RS09200	COG4472	Bacterial protein of unknown function (DUF965)
SanJ4206_RS09215	COG1393	Belongs to the ArsC family
SanJ4206_RS09220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SanJ4206_RS09225	COG1546	Belongs to the CinA family
SanJ4206_RS09225	COG1058	Belongs to the CinA family
SanJ4206_RS09245	COG2818	Glycosylase
SanJ4206_RS09250	COG0632	four-way junction helicase activity
SanJ4206_RS09255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SanJ4206_RS09260	COG0582	viral genome integration into host DNA
SanJ4206_RS09360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SanJ4206_RS09365	COG1438	arginine binding
SanJ4206_RS09370	COG0018	arginyl-trna synthetase
SanJ4206_RS09375	COG1780	Probably involved in ribonucleotide reductase function
SanJ4206_RS09385	COG0058	SHG alpha-glucan phosphorylase activity
SanJ4206_RS09390	COG1640	4-alpha-glucanotransferase
SanJ4206_RS09400	COG2182	Extracellular solute-binding protein
SanJ4206_RS09405	COG1175	transmembrane transport
SanJ4206_RS09410	COG3833	ABC-type maltose transport systems, permease component
SanJ4206_RS09415	COG5521	maltodextrose utilization protein MalA
SanJ4206_RS09420	COG1609	Transcriptional regulator
SanJ4206_RS09425	COG1523	belongs to the glycosyl hydrolase 13 family
SanJ4206_RS09430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SanJ4206_RS09445	COG0124	histidyl-tRNA synthetase
SanJ4206_RS09450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SanJ4206_RS09455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SanJ4206_RS09490	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SanJ4206_RS09520	COG2807	transmembrane transport
SanJ4206_RS09525	COG2094	Belongs to the DNA glycosylase MPG family
SanJ4206_RS09530	COG0561	phosphatase activity
SanJ4206_RS09535	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SanJ4206_RS09540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SanJ4206_RS09545	COG1696	Membrane protein involved in D-alanine export
SanJ4206_RS09610	COG0561	phosphatase activity
SanJ4206_RS09630	COG1011	Hydrolase
SanJ4206_RS09640	COG0305	Participates in initiation and elongation during chromosome replication
SanJ4206_RS09655	COG0445	tRNA wobble uridine modification
SanJ4206_RS09660	COG0482	sulfurtransferase activity
SanJ4206_RS09670	COG1760	l-serine dehydratase
SanJ4206_RS09675	COG1760	l-serine dehydratase
SanJ4206_RS09690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SanJ4206_RS09695	COG1122	ATPase activity
SanJ4206_RS09700	COG1122	ATPase activity
SanJ4206_RS09705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SanJ4206_RS09715	COG0612	Peptidase, M16
SanJ4206_RS09720	COG0612	Peptidase, M16
SanJ4206_RS09730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SanJ4206_RS09735	COG0516	GMP reductase activity
SanJ4206_RS09735	COG0517	IMP dehydrogenase activity
SanJ4206_RS09740	COG0180	Tryptophanyl-tRNA synthetase
SanJ4206_RS09745	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SanJ4206_RS09750	COG0149	triose-phosphate isomerase activity
SanJ4206_RS09760	COG0488	(ABC) transporter
SanJ4206_RS09805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SanJ4206_RS09810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SanJ4206_RS09815	COG1475	DNA binding