locus-tag	class	description
LK450_RS00010	COG1263	PTS System
LK450_RS00010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK450_RS00010	COG2190	(PTS) system
LK450_RS00025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LK450_RS00035	COG1484	DNA-dependent DNA replication
LK450_RS00045	COG1160	GTP binding
LK450_RS00055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LK450_RS00065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LK450_RS00080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LK450_RS00100	COG1254	Belongs to the acylphosphatase family
LK450_RS00105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LK450_RS00130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LK450_RS00135	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LK450_RS00150	COG4974	Belongs to the 'phage' integrase family
LK450_RS00155	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LK450_RS00160	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LK450_RS00165	COG1187	pseudouridine synthase activity
LK450_RS00170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LK450_RS00200	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
LK450_RS00220	COG3695	enzyme binding
LK450_RS00225	COG1242	4 iron, 4 sulfur cluster binding
LK450_RS00230	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LK450_RS00240	COG0025	NhaP-type Na H and K H
LK450_RS00250	COG0494	nUDIX hydrolase
LK450_RS00265	COG0542	response to heat
LK450_RS00270	COG4703	Protein of unknown function (DUF1797)
LK450_RS00305	COG1136	(ABC) transporter
LK450_RS00310	COG0577	efflux transmembrane transporter activity
LK450_RS00315	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LK450_RS00320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LK450_RS00335	COG1570	exodeoxyribonuclease VII activity
LK450_RS00340	COG1722	exodeoxyribonuclease VII activity
LK450_RS00350	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
LK450_RS00355	COG1438	arginine binding
LK450_RS00360	COG0497	DNA recombination
LK450_RS00365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LK450_RS00370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LK450_RS00375	COG4604	ABC transporter, ATP-binding protein
LK450_RS00380	COG4605	iron ion homeostasis
LK450_RS00385	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LK450_RS00390	COG1307	EDD domain protein, DegV family
LK450_RS00405	COG0588	phosphoglycerate mutase activity
LK450_RS00410	COG0768	penicillin binding
LK450_RS00415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LK450_RS00420	COG1181	Belongs to the D-alanine--D-alanine ligase family
LK450_RS00425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LK450_RS00445	COG3620	sequence-specific DNA binding
LK450_RS00465	COG0513	Belongs to the DEAD box helicase family
LK450_RS00475	COG1349	DNA-binding transcription factor activity
LK450_RS00480	COG0698	ribose 5-phosphate isomerase
LK450_RS00500	COG3775	system Galactitol-specific IIC component
LK450_RS00510	COG1755	Isoprenylcysteine carboxyl methyltransferase
LK450_RS00515	COG3711	transcriptional antiterminator
LK450_RS00520	COG2723	6-phospho-beta-galactosidase activity
LK450_RS00525	COG1447	Phosphotransferase system cellobiose-specific component IIA
LK450_RS00530	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LK450_RS00530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LK450_RS00535	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LK450_RS00540	COG2827	Endonuclease containing a URI domain
LK450_RS00545	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LK450_RS00550	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LK450_RS00555	COG0204	Acyl-transferase
LK450_RS00570	COG1476	TRANSCRIPTIONal
LK450_RS00585	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LK450_RS00595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LK450_RS00605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK450_RS00610	COG0322	excinuclease ABC activity
LK450_RS00620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK450_RS00630	COG1573	uracil-dna glycosylase
LK450_RS00640	COG1732	Glycine betaine
LK450_RS00645	COG1125	glycine betaine transport
LK450_RS00650	COG1063	alcohol dehydrogenase
LK450_RS00665	COG0254	rRNA binding
LK450_RS00670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LK450_RS00675	COG0716	FMN binding
LK450_RS00685	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
LK450_RS00690	COG1518	maintenance of DNA repeat elements
LK450_RS00715	COG1309	transcriptional regulator
LK450_RS00720	COG1136	(ABC) transporter
LK450_RS00735	COG1959	2 iron, 2 sulfur cluster binding
LK450_RS00740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LK450_RS00745	COG1349	DNA-binding transcription factor activity
LK450_RS00755	COG1447	Phosphotransferase system cellobiose-specific component IIA
LK450_RS00765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LK450_RS00770	COG1882	Formate acetyltransferase
LK450_RS00810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LK450_RS00815	COG0406	alpha-ribazole phosphatase activity
LK450_RS00820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LK450_RS00835	COG0772	Belongs to the SEDS family
LK450_RS00840	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LK450_RS00845	COG1595	DNA-templated transcription, initiation
LK450_RS00855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LK450_RS00870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LK450_RS00875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LK450_RS00885	COG0813	purine-nucleoside phosphorylase activity
LK450_RS00895	COG1368	sulfuric ester hydrolase activity
LK450_RS00900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LK450_RS00905	COG0710	3-dehydroquinate dehydratase activity
LK450_RS00910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LK450_RS00915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LK450_RS00920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LK450_RS00925	COG0730	response to heat
LK450_RS00935	COG0287	Prephenate dehydrogenase
LK450_RS00940	COG3679	Belongs to the UPF0342 family
LK450_RS00950	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LK450_RS00955	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LK450_RS00960	COG0077	Prephenate dehydratase
LK450_RS00970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LK450_RS00995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LK450_RS01075	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
LK450_RS01140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LK450_RS01140	COG0551	DNA topoisomerase type I activity
LK450_RS01180	COG0556	nucleotide-excision repair
LK450_RS01195	COG1725	Transcriptional regulator
LK450_RS01200	COG0842	Transport permease protein
LK450_RS01200	COG1129	ABC transporter
LK450_RS01245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK450_RS01250	COG0492	ferredoxin-NADP+ reductase activity
LK450_RS01260	COG1349	DNA-binding transcription factor activity
LK450_RS01265	COG1105	Belongs to the carbohydrate kinase PfkB family
LK450_RS01270	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK450_RS01270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK450_RS01270	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LK450_RS01280	COG1307	EDD domain protein, DegV family
LK450_RS01285	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LK450_RS01290	COG0617	tRNA 3'-terminal CCA addition
LK450_RS01295	COG0488	(ABC) transporter
LK450_RS01310	COG0072	phenylalanine-tRNA ligase activity
LK450_RS01310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK450_RS01335	COG1263	PTS System
LK450_RS01335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK450_RS01335	COG2190	(PTS) system
LK450_RS01340	COG2723	6-phospho-beta-galactosidase activity
LK450_RS01350	COG1011	Hydrolase
LK450_RS01365	COG1268	BioY protein
LK450_RS01370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK450_RS01380	COG1136	(ABC) transporter
LK450_RS01385	COG0577	efflux transmembrane transporter activity
LK450_RS01395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LK450_RS01400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LK450_RS01420	COG0300	oxidoreductase activity
LK450_RS01435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LK450_RS01435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LK450_RS01445	COG1131	(ABC) transporter
LK450_RS01450	COG1725	Transcriptional regulator
LK450_RS01460	COG0205	6-phosphofructokinase activity
LK450_RS01465	COG0469	pyruvate kinase activity
LK450_RS01475	COG0765	amino acid transport
LK450_RS01480	COG1126	abc transporter atp-binding protein
LK450_RS01490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LK450_RS01495	COG0210	DNA helicase
LK450_RS01505	COG2378	regulation of single-species biofilm formation
LK450_RS01510	COG1132	(ABC) transporter
LK450_RS01510	COG2375	cellular response to nickel ion
LK450_RS01515	COG1132	(ABC) transporter
LK450_RS01525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LK450_RS01530	COG0196	riboflavin kinase activity
LK450_RS01535	COG1393	Belongs to the ArsC family
LK450_RS01540	COG4476	Belongs to the UPF0223 family
LK450_RS01545	COG0483	inositol monophosphate 1-phosphatase activity
LK450_RS01550	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LK450_RS01550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LK450_RS01560	COG0573	inorganic phosphate transmembrane transporter activity
LK450_RS01565	COG0581	inorganic phosphate transmembrane transporter activity
LK450_RS01570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LK450_RS01575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LK450_RS01580	COG0704	Plays a role in the regulation of phosphate uptake
LK450_RS01585	COG2003	Belongs to the UPF0758 family
LK450_RS01590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LK450_RS01605	COG1104	cysteine desulfurase activity
LK450_RS01610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LK450_RS01620	COG2357	RelA SpoT domain protein
LK450_RS01625	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LK450_RS01630	COG0564	pseudouridine synthase activity
LK450_RS01635	COG0280	phosphate acetyltransferase
LK450_RS01650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK450_RS01655	COG4684	Psort location CytoplasmicMembrane, score
LK450_RS01660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LK450_RS01670	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LK450_RS01675	COG1247	-acetyltransferase
LK450_RS01690	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LK450_RS01695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK450_RS01710	COG3708	Transcriptional regulator
LK450_RS01710	COG2207	Transcriptional regulator
LK450_RS01715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LK450_RS01720	COG0222	ribosome binding
LK450_RS01740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LK450_RS01745	COG0336	Belongs to the RNA methyltransferase TrmD family
LK450_RS01750	COG3443	Belongs to the bacterial solute-binding protein 9 family
LK450_RS01750	COG0803	Belongs to the bacterial solute-binding protein 9 family
LK450_RS01765	COG1956	GAF domain-containing protein
LK450_RS01770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LK450_RS01785	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
LK450_RS01785	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
LK450_RS01790	COG1609	Transcriptional regulator
LK450_RS01795	COG2207	Transcriptional regulator
LK450_RS01800	COG3345	alpha-galactosidase
LK450_RS01805	COG1653	transport
LK450_RS01810	COG1175	transmembrane transport
LK450_RS01815	COG0395	ABC-type sugar transport system, permease component
LK450_RS01820	COG0366	Alpha amylase catalytic
LK450_RS01825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LK450_RS01830	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LK450_RS01835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LK450_RS01845	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LK450_RS01855	COG0726	polysaccharide deacetylase
LK450_RS01865	COG0083	homoserine kinase activity
LK450_RS01885	COG0656	L-ascorbic acid biosynthetic process
LK450_RS01895	COG0583	DNA-binding transcription factor activity
LK450_RS01900	COG2814	Major facilitator Superfamily
LK450_RS01905	COG0583	DNA-binding transcription factor activity
LK450_RS01935	COG0543	2 iron, 2 sulfur cluster binding
LK450_RS01940	COG0167	dihydroorotate dehydrogenase activity
LK450_RS01945	COG0284	orotidine-5'-phosphate decarboxylase activity
LK450_RS01955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LK450_RS01970	COG4479	Belongs to the UPF0346 family
LK450_RS01975	COG1702	phosphate starvation-inducible protein PhoH
LK450_RS01990	COG0686	Belongs to the AlaDH PNT family
LK450_RS01995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LK450_RS02010	COG1132	(ABC) transporter
LK450_RS02015	COG1132	(ABC) transporter
LK450_RS02020	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LK450_RS02025	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LK450_RS02030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LK450_RS02055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LK450_RS02060	COG0237	dephospho-CoA kinase activity
LK450_RS02065	COG2814	Major facilitator Superfamily
LK450_RS02070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LK450_RS02080	COG0557	exoribonuclease II activity
LK450_RS02090	COG1555	photosystem II stabilization
LK450_RS02095	COG2333	competence protein COMEC
LK450_RS02095	COG0658	competence protein
LK450_RS02110	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LK450_RS02115	COG1051	belongs to the nudix hydrolase family
LK450_RS02120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LK450_RS02125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LK450_RS02130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LK450_RS02140	COG4109	DRTGG domain
LK450_RS02145	COG0024	Methionine aminopeptidase
LK450_RS02175	COG0395	ABC-type sugar transport system, permease component
LK450_RS02190	COG2273	Hydrolase Family 16
LK450_RS02195	COG2207	Transcriptional regulator
LK450_RS02200	COG1846	Transcriptional regulator
LK450_RS02210	COG2246	polysaccharide biosynthetic process
LK450_RS02215	COG4708	membrane
LK450_RS02220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LK450_RS02225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LK450_RS02230	COG1597	lipid kinase activity
LK450_RS02235	COG1523	belongs to the glycosyl hydrolase 13 family
LK450_RS02240	COG0228	four-way junction DNA binding
LK450_RS02245	COG1837	Belongs to the UPF0109 family
LK450_RS02250	COG1827	regulation of RNA biosynthetic process
LK450_RS02265	COG3142	Participates in the control of copper homeostasis
LK450_RS02270	COG2315	Protein conserved in bacteria
LK450_RS02275	COG1132	(ABC) transporter
LK450_RS02280	COG1132	(ABC) transporter
LK450_RS02285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LK450_RS02300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LK450_RS02305	COG1970	mechanosensitive ion channel activity
LK450_RS02310	COG0358	DNA primase activity
LK450_RS02315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LK450_RS02320	COG2151	metal-sulfur cluster biosynthetic enzyme
LK450_RS02325	COG1114	Component of the transport system for branched-chain amino acids
LK450_RS02330	COG0785	Cytochrome C biogenesis protein
LK450_RS02335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK450_RS02340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK450_RS02340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK450_RS02345	COG4753	response regulator
LK450_RS02345	COG2207	Transcriptional regulator
LK450_RS02350	COG2972	Histidine kinase
LK450_RS02365	COG4555	ABC transporter
LK450_RS02370	COG1053	succinate dehydrogenase
LK450_RS02370	COG0431	NADPH-dependent FMN reductase
LK450_RS02370	COG3976	FMN-binding domain protein
LK450_RS02390	COG2205	protein histidine kinase activity
LK450_RS02395	COG0745	RESPONSE REGULATOR receiver
LK450_RS02425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LK450_RS02430	COG2233	PERMEase
LK450_RS02435	COG0534	Mate efflux family protein
LK450_RS02440	COG1942	4-Oxalocrotonate Tautomerase
LK450_RS02445	COG1435	thymidine kinase activity
LK450_RS02455	COG2890	protein-(glutamine-N5) methyltransferase activity
LK450_RS02465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LK450_RS02475	COG0741	lytic transglycosylase activity
LK450_RS02540	COG2188	Transcriptional regulator
LK450_RS02550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LK450_RS02555	COG1136	(ABC) transporter
LK450_RS02560	COG4974	Belongs to the 'phage' integrase family
LK450_RS02565	COG1028	Short-chain dehydrogenase reductase Sdr
LK450_RS02570	COG0095	Lipoate-protein ligase
LK450_RS02575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK450_RS02580	COG0508	dehydrogenase complex catalyzes the overall conversion of
LK450_RS02585	COG0022	dehydrogenase e1 component
LK450_RS02590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LK450_RS02610	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LK450_RS02615	COG0135	phosphoribosylanthranilate isomerase activity
LK450_RS02620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LK450_RS02625	COG0758	DNA mediated transformation
LK450_RS02630	COG0110	maltose O-acetyltransferase activity
LK450_RS02635	COG3711	transcriptional antiterminator
LK450_RS02640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LK450_RS02645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LK450_RS02650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LK450_RS02655	COG1960	acyl-CoA dehydrogenase activity
LK450_RS02660	COG0583	DNA-binding transcription factor activity
LK450_RS02665	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
LK450_RS02675	COG1024	Enoyl-CoA hydratase
LK450_RS02680	COG0183	Belongs to the thiolase family
LK450_RS02685	COG1250	3-hydroxyacyl-CoA dehydrogenase
LK450_RS02690	COG1960	acyl-CoA dehydrogenase activity
LK450_RS02695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LK450_RS02700	COG3764	Sortase (surface protein transpeptidase)
LK450_RS02705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LK450_RS02710	COG0039	L-malate dehydrogenase activity
LK450_RS02725	COG0539	negative regulation of cytoplasmic translation
LK450_RS02745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LK450_RS02750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LK450_RS02770	COG0187	DNA topoisomerase II activity
LK450_RS02775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LK450_RS02785	COG2131	deaminase
LK450_RS02835	COG2814	Major facilitator Superfamily
LK450_RS02840	COG0017	Asparaginyl-tRNA synthetase
LK450_RS02850	COG0436	Aminotransferase
LK450_RS02860	COG1846	Transcriptional regulator
LK450_RS02870	COG3022	response to hydroperoxide
LK450_RS02880	COG1272	protein, Hemolysin III
LK450_RS02885	COG1079	Belongs to the binding-protein-dependent transport system permease family
LK450_RS02890	COG4603	Belongs to the binding-protein-dependent transport system permease family
LK450_RS02895	COG3845	ABC transporter
LK450_RS02900	COG1744	ABC transporter substrate-binding protein PnrA-like
LK450_RS02905	COG0295	cytidine deaminase activity
LK450_RS02910	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LK450_RS02920	COG2813	Specifically methylates the guanine in position
LK450_RS02925	COG1072	(Pantothenic acid kinase))
LK450_RS02930	COG0268	Binds directly to 16S ribosomal RNA
LK450_RS02940	COG4187	Peptidase family M20/M25/M40
LK450_RS02950	COG5002	protein histidine kinase activity
LK450_RS02955	COG0745	RESPONSE REGULATOR receiver
LK450_RS03010	COG1674	ftsk spoiiie
LK450_RS03045	COG1940	carbohydrate kinase activity
LK450_RS03050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LK450_RS03055	COG0505	Belongs to the CarA family
LK450_RS03060	COG0540	Belongs to the ATCase OTCase family
LK450_RS03070	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LK450_RS03075	COG1481	regulation of sporulation
LK450_RS03080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LK450_RS03085	COG1660	Displays ATPase and GTPase activities
LK450_RS03105	COG0647	UMP catabolic process
LK450_RS03110	COG1051	belongs to the nudix hydrolase family
LK450_RS03120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LK450_RS03130	COG1131	(ABC) transporter
LK450_RS03140	COG0556	nucleotide-excision repair
LK450_RS03160	COG0488	(ABC) transporter
LK450_RS03165	COG1132	(ABC) transporter
LK450_RS03175	COG1705	Flagellar rod assembly protein muramidase FlgJ
LK450_RS03175	COG1388	LysM domain
LK450_RS03180	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LK450_RS03195	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LK450_RS03200	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LK450_RS03205	COG0038	chloride channel
LK450_RS03245	COG2824	Alkylphosphonate utilization operon protein PhnA
LK450_RS03250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LK450_RS03255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LK450_RS03260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LK450_RS03265	COG0564	pseudouridine synthase activity
LK450_RS03275	COG0583	DNA-binding transcription factor activity
LK450_RS03280	COG1937	Protein conserved in bacteria
LK450_RS03295	COG0446	pyridine nucleotide-disulphide oxidoreductase
LK450_RS03300	COG0425	Belongs to the sulfur carrier protein TusA family
LK450_RS03300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LK450_RS03315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LK450_RS03325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LK450_RS03330	COG0301	tRNA thio-modification
LK450_RS03335	COG1104	cysteine desulfurase activity
LK450_RS03340	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
LK450_RS03345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LK450_RS03350	COG0517	IMP dehydrogenase activity
LK450_RS03355	COG0574	Belongs to the PEP-utilizing enzyme family
LK450_RS03355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LK450_RS03370	COG1177	transmembrane transport
LK450_RS03375	COG1176	ABC-type spermidine putrescine transport system, permease component I
LK450_RS03380	COG3842	ATPase activity
LK450_RS03385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LK450_RS03395	COG0481	GTPase activity
LK450_RS03400	COG0561	phosphatase activity
LK450_RS03405	COG2195	Cleaves the N-terminal amino acid of tripeptides
LK450_RS03415	COG0572	uridine kinase
LK450_RS03430	COG0726	polysaccharide deacetylase
LK450_RS03435	COG0346	lactoylglutathione lyase activity
LK450_RS03445	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LK450_RS03455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LK450_RS03480	COG0560	Phosphoserine phosphatase
LK450_RS03485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LK450_RS03495	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
LK450_RS03500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LK450_RS03505	COG3442	glutamine amidotransferase
LK450_RS03510	COG2814	Major facilitator Superfamily
LK450_RS03520	COG0488	(ABC) transporter
LK450_RS03545	COG0826	peptidase U32
LK450_RS03570	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LK450_RS03575	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LK450_RS03590	COG3091	SprT-like family
LK450_RS03595	COG2183	response to ionizing radiation
LK450_RS03605	COG0701	Predicted permease
LK450_RS03610	COG3689	TIGRFAM TIGR03943 family protein
LK450_RS03615	COG0477	Major facilitator Superfamily
LK450_RS03620	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LK450_RS03625	COG0552	protein localization to endoplasmic reticulum
LK450_RS03630	COG0561	phosphatase activity
LK450_RS03635	COG0561	phosphatase activity
LK450_RS03640	COG1196	nuclear chromosome segregation
LK450_RS03645	COG0571	ribonuclease III activity
LK450_RS03655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LK450_RS03660	COG5002	protein histidine kinase activity
LK450_RS03665	COG0745	RESPONSE REGULATOR receiver
LK450_RS03675	COG0438	transferase activity, transferring glycosyl groups
LK450_RS03685	COG1609	Transcriptional regulator
LK450_RS03690	COG0006	proline dipeptidase activity
LK450_RS03695	COG1368	sulfuric ester hydrolase activity
LK450_RS03730	COG1091	dTDP-4-dehydrorhamnose reductase activity
LK450_RS03735	COG0463	Glycosyl transferase, family 2
LK450_RS03760	COG0463	Glycosyl transferase, family 2
LK450_RS03765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LK450_RS03770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LK450_RS03775	COG1088	dTDP-glucose 4,6-dehydratase activity
LK450_RS03785	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LK450_RS03795	COG1051	belongs to the nudix hydrolase family
LK450_RS03800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LK450_RS03805	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LK450_RS03810	COG2384	SAM-dependent methyltransferase
LK450_RS03825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LK450_RS03830	COG1346	cytolysis
LK450_RS03855	COG1132	(ABC) transporter
LK450_RS03875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LK450_RS03895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LK450_RS03900	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LK450_RS03905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK450_RS03910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LK450_RS03915	COG0356	it plays a direct role in the translocation of protons across the membrane
LK450_RS03925	COG0058	SHG alpha-glucan phosphorylase activity
LK450_RS03930	COG0297	glycogen (starch) synthase activity
LK450_RS03935	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LK450_RS03940	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LK450_RS03945	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
LK450_RS03950	COG1074	ATP-dependent DNA helicase activity
LK450_RS03955	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LK450_RS03960	COG1668	transmembrane transport
LK450_RS03965	COG4152	abc transporter atp-binding protein
LK450_RS03970	COG4443	Transcriptional Coactivator p15 (PC4)
LK450_RS03980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LK450_RS03995	COG1293	RNA-binding protein homologous to eukaryotic snRNP
LK450_RS04000	COG3527	Alpha-acetolactate decarboxylase
LK450_RS04005	COG0028	Belongs to the TPP enzyme family
LK450_RS04015	COG0628	permease
LK450_RS04020	COG3850	Histidine kinase
LK450_RS04020	COG5002	protein histidine kinase activity
LK450_RS04025	COG0745	RESPONSE REGULATOR receiver
LK450_RS04030	COG2706	6-phosphogluconolactonase activity
LK450_RS04035	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LK450_RS04040	COG0187	DNA topoisomerase II activity
LK450_RS04050	COG0693	protein deglycase activity
LK450_RS04055	COG0772	Belongs to the SEDS family
LK450_RS04065	COG1199	ATP-dependent helicase activity
LK450_RS04065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LK450_RS04075	COG2177	Part of the ABC transporter FtsEX involved in
LK450_RS04080	COG2884	Cell division ATP-binding protein ftsE
LK450_RS04090	COG0561	phosphatase activity
LK450_RS04115	COG1078	dGTPase activity
LK450_RS04125	COG2348	transferase activity, transferring amino-acyl groups
LK450_RS04130	COG2348	transferase activity, transferring amino-acyl groups
LK450_RS04135	COG2274	protein secretion by the type I secretion system
LK450_RS04145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LK450_RS04155	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LK450_RS04165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LK450_RS04170	COG4122	O-methyltransferase activity
LK450_RS04195	COG0363	glucosamine-6-phosphate deaminase activity
LK450_RS04200	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LK450_RS04205	COG1438	arginine binding
LK450_RS04210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LK450_RS04215	COG1288	antiporter activity
LK450_RS04220	COG0549	Belongs to the carbamate kinase family
LK450_RS04225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LK450_RS04260	COG2274	protein secretion by the type I secretion system
LK450_RS04265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LK450_RS04270	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LK450_RS04275	COG1466	dna polymerase III delta subunit
LK450_RS04280	COG2996	Protein conserved in bacteria
LK450_RS04285	COG0233	cytoplasmic translational termination
LK450_RS04290	COG0528	UMP kinase activity
LK450_RS04295	COG0538	isocitrate dehydrogenase activity
LK450_RS04300	COG0372	Belongs to the citrate synthase family
LK450_RS04305	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LK450_RS04310	COG0081	regulation of translation
LK450_RS04325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LK450_RS04330	COG0697	spore germination
LK450_RS04330	COG1674	ftsk spoiiie
LK450_RS04335	COG1983	PspC domain protein
LK450_RS04340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LK450_RS04345	COG0488	(ABC) transporter
LK450_RS04355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LK450_RS04370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LK450_RS04385	COG1028	Short-chain dehydrogenase reductase Sdr
LK450_RS04415	COG0531	amino acid
LK450_RS04420	COG0577	efflux transmembrane transporter activity
LK450_RS04425	COG1136	(ABC) transporter
LK450_RS04450	COG0577	efflux transmembrane transporter activity
LK450_RS04455	COG1136	(ABC) transporter
LK450_RS04465	COG0642	Histidine kinase
LK450_RS04470	COG0745	RESPONSE REGULATOR receiver
LK450_RS04480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK450_RS04480	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK450_RS04505	COG0640	Transcriptional regulator
LK450_RS04520	COG0708	Exodeoxyribonuclease III
LK450_RS04525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LK450_RS04530	COG1393	Belongs to the ArsC family
LK450_RS04535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LK450_RS04545	COG4467	Involved in initiation control of chromosome replication
LK450_RS04550	COG0470	DNA polymerase III
LK450_RS04555	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LK450_RS04560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LK450_RS04565	COG0517	IMP dehydrogenase activity
LK450_RS04580	COG4177	L-phenylalanine transmembrane transporter activity
LK450_RS04600	COG0740	serine-type endopeptidase activity
LK450_RS04605	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LK450_RS04610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LK450_RS04615	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LK450_RS04620	COG0626	cystathionine gamma-synthase activity
LK450_RS04625	COG2244	polysaccharide biosynthetic process
LK450_RS04630	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LK450_RS04655	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LK450_RS04665	COG0366	Alpha amylase catalytic
LK450_RS04670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK450_RS04670	COG1263	PTS System
LK450_RS04675	COG2188	Transcriptional regulator
LK450_RS04680	COG1253	flavin adenine dinucleotide binding
LK450_RS04690	COG0628	permease
LK450_RS04700	COG1846	Transcriptional regulator
LK450_RS04705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LK450_RS04710	COG3599	regulation of cell shape
LK450_RS04725	COG1799	cell septum assembly
LK450_RS04730	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LK450_RS04745	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LK450_RS04750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LK450_RS04755	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LK450_RS04765	COG1217	gtp-binding protein TYPA
LK450_RS04770	COG1187	pseudouridine synthase activity
LK450_RS04790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LK450_RS04800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LK450_RS04805	COG4470	Protein conserved in bacteria
LK450_RS04810	COG3480	Lon protease (S16) C-terminal proteolytic domain
LK450_RS04815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LK450_RS04820	COG0742	ribosomal rna small subunit methyltransferase
LK450_RS04830	COG1040	competence protein
LK450_RS04835	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LK450_RS04840	COG1739	Uncharacterized protein family UPF0029
LK450_RS04870	COG0519	Catalyzes the synthesis of GMP from XMP
LK450_RS04890	COG2070	2-Nitropropane dioxygenase
LK450_RS04900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LK450_RS04905	COG2137	regulation of response to DNA damage stimulus
LK450_RS04910	COG3557	Belongs to the UPF0374 family
LK450_RS04920	COG1185	polyribonucleotide nucleotidyltransferase activity
LK450_RS04945	COG2815	serine threonine protein kinase
LK450_RS04945	COG0515	serine threonine protein kinase
LK450_RS04950	COG0631	protein serine/threonine phosphatase activity
LK450_RS04955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LK450_RS04955	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LK450_RS04960	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LK450_RS04965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LK450_RS04970	COG1758	RNA polymerase activity
LK450_RS04975	COG0194	GDP metabolic process
LK450_RS04980	COG1418	mRNA catabolic process
LK450_RS04990	COG3634	alkyl hydroperoxide reductase activity
LK450_RS04995	COG0450	alkyl hydroperoxide reductase
LK450_RS05005	COG0116	Belongs to the methyltransferase superfamily
LK450_RS05015	COG3599	regulation of cell shape
LK450_RS05020	COG4474	Belongs to the UPF0398 family
LK450_RS05025	COG3331	DNA recombination
LK450_RS05030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK450_RS05035	COG3579	cysteine-type endopeptidase activity
LK450_RS05040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LK450_RS05045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LK450_RS05050	COG1113	amino acid transport
LK450_RS05055	COG0492	ferredoxin-NADP+ reductase activity
LK450_RS05065	COG1126	abc transporter atp-binding protein
LK450_RS05075	COG0513	Belongs to the DEAD box helicase family
LK450_RS05080	COG1686	Belongs to the peptidase S11 family
LK450_RS05090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LK450_RS05095	COG0719	Fe-S assembly protein
LK450_RS05105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK450_RS05110	COG4862	establishment of competence for transformation
LK450_RS05115	COG1968	undecaprenyl-diphosphatase activity
LK450_RS05125	COG0765	amino acid transport
LK450_RS05130	COG1126	abc transporter atp-binding protein
LK450_RS05160	COG1131	(ABC) transporter
LK450_RS05210	COG1461	Dihydroxyacetone kinase
LK450_RS05220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LK450_RS05245	COG0191	fructose-bisphosphate aldolase activity
LK450_RS05255	COG4166	transmembrane transport
LK450_RS05260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LK450_RS05265	COG0768	penicillin binding
LK450_RS05275	COG0275	rRNA processing
LK450_RS05285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LK450_RS05300	COG0751	glycine-tRNA ligase activity
LK450_RS05305	COG0752	glycyl-tRNA synthetase alpha subunit
LK450_RS05335	COG0656	L-ascorbic acid biosynthetic process
LK450_RS05350	COG1283	sodium-dependent phosphate transmembrane transporter activity
LK450_RS05355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LK450_RS05370	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LK450_RS05375	COG0195	Participates in both transcription termination and antitermination
LK450_RS05380	COG0779	Required for maturation of 30S ribosomal subunits
LK450_RS05390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LK450_RS05395	COG0510	thiamine kinase activity
LK450_RS05405	COG1131	(ABC) transporter
LK450_RS05410	COG0537	adenosine 5'-monophosphoramidase activity
LK450_RS05420	COG1316	TRANSCRIPTIONal
LK450_RS05430	COG0802	atpase or kinase
LK450_RS05435	COG2252	PERMEase
LK450_RS05445	COG0561	phosphatase activity
LK450_RS05455	COG3715	PTS system
LK450_RS05460	COG3716	PTS system mannose fructose sorbose family IID component
LK450_RS05475	COG0586	Pfam SNARE associated Golgi protein
LK450_RS05480	COG0825	malonyl-CoA metabolic process
LK450_RS05485	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LK450_RS05490	COG0439	Biotin carboxylase
LK450_RS05495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LK450_RS05505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LK450_RS05515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LK450_RS05520	COG2070	2-Nitropropane dioxygenase
LK450_RS05530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LK450_RS05540	COG1024	Enoyl-CoA hydratase
LK450_RS05545	COG0527	aspartate kinase activity
LK450_RS05590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LK450_RS05595	COG0006	proline dipeptidase activity
LK450_RS05605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LK450_RS05620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LK450_RS05625	COG0629	single-stranded DNA binding
LK450_RS05650	COG0588	phosphoglycerate mutase activity
LK450_RS05685	COG1122	ATPase activity
LK450_RS05710	COG5002	protein histidine kinase activity
LK450_RS05715	COG0745	RESPONSE REGULATOR receiver
LK450_RS05720	COG2723	6-phospho-beta-galactosidase activity
LK450_RS05725	COG1304	FMN binding
LK450_RS05730	COG0028	Belongs to the TPP enzyme family
LK450_RS05735	COG1876	peptidase activity
LK450_RS05760	COG0561	phosphatase activity
LK450_RS05770	COG0346	lactoylglutathione lyase activity
LK450_RS05800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK450_RS05800	COG2190	(PTS) system
LK450_RS05800	COG1263	PTS System
LK450_RS05805	COG1447	Phosphotransferase system cellobiose-specific component IIA
LK450_RS05810	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LK450_RS05820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LK450_RS05825	COG1940	carbohydrate kinase activity
LK450_RS05865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK450_RS05865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LK450_RS05870	COG0167	dihydroorotate dehydrogenase activity
LK450_RS05875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LK450_RS05885	COG0668	transmembrane transport
LK450_RS05890	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LK450_RS05895	COG3118	belongs to the thioredoxin family
LK450_RS05905	COG1193	negative regulation of DNA recombination
LK450_RS05925	COG0681	Belongs to the peptidase S26 family
LK450_RS05930	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LK450_RS05935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LK450_RS05940	COG1882	Formate acetyltransferase
LK450_RS05955	COG3425	synthase
LK450_RS05965	COG1304	FMN binding
LK450_RS05985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LK450_RS06000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK450_RS06005	COG2936	dipeptidyl-peptidase activity
LK450_RS06065	COG0582	viral genome integration into host DNA
LK450_RS06070	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LK450_RS06075	COG0584	glycerophosphoryl diester phosphodiesterase
LK450_RS06080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LK450_RS06090	COG2081	HI0933 family
LK450_RS06095	COG0789	Transcriptional regulator
LK450_RS06250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LK450_RS06255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LK450_RS06260	COG0564	pseudouridine synthase activity
LK450_RS06280	COG0803	Belongs to the bacterial solute-binding protein 9 family
LK450_RS06280	COG3443	Belongs to the bacterial solute-binding protein 9 family
LK450_RS06285	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LK450_RS06290	COG1121	(ABC) transporter
LK450_RS06295	COG1846	Transcriptional regulator
LK450_RS06320	COG1914	H( )-stimulated, divalent metal cation uptake system
LK450_RS06325	COG3759	membrane
LK450_RS06345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LK450_RS06350	COG1394	ATPase activity, coupled to movement of substances
LK450_RS06355	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
LK450_RS06360	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
LK450_RS06370	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
LK450_RS06375	COG1527	subunit (C
LK450_RS06385	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LK450_RS06390	COG1269	ATP hydrolysis coupled proton transport
LK450_RS06410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LK450_RS06425	COG0395	ABC-type sugar transport system, permease component
LK450_RS06430	COG1175	transmembrane transport
LK450_RS06440	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
LK450_RS06450	COG1454	alcohol dehydrogenase
LK450_RS06455	COG1454	alcohol dehydrogenase
LK450_RS06455	COG1012	belongs to the aldehyde dehydrogenase family
LK450_RS06470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LK450_RS06480	COG2255	four-way junction helicase activity
LK450_RS06490	COG3684	Belongs to the aldolase LacD family
LK450_RS06495	COG2222	sugar isomerase
LK450_RS06505	COG3716	PTS system mannose fructose sorbose family IID component
LK450_RS06515	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK450_RS06530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LK450_RS06535	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LK450_RS06540	COG1461	Dihydroxyacetone kinase
LK450_RS06545	COG2376	Dihydroxyacetone kinase
LK450_RS06555	COG2376	Dihydroxyacetone kinase
LK450_RS06560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LK450_RS06600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LK450_RS06605	COG1683	Conserved Protein
LK450_RS06610	COG0151	Belongs to the GarS family
LK450_RS06615	COG3942	CHAP domain
LK450_RS06630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LK450_RS06635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LK450_RS06650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LK450_RS06655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK450_RS06665	COG1381	Involved in DNA repair and RecF pathway recombination
LK450_RS06670	COG0436	Aminotransferase
LK450_RS06675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LK450_RS06680	COG3942	CHAP domain
LK450_RS06690	COG1792	Involved in formation and maintenance of cell shape
LK450_RS06810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LK450_RS06815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LK450_RS06820	COG0037	tRNA processing
LK450_RS06835	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LK450_RS06840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LK450_RS06845	COG0193	aminoacyl-tRNA hydrolase activity
LK450_RS06850	COG0012	GTP binding
LK450_RS06865	COG0592	DNA-directed DNA polymerase activity
LK450_RS06875	COG1475	DNA binding
LK450_RS06880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LK450_RS06885	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LK450_RS06925	COG0488	(ABC) transporter
LK450_RS06935	COG0149	triose-phosphate isomerase activity
LK450_RS06940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LK450_RS06945	COG0180	Tryptophanyl-tRNA synthetase
LK450_RS06950	COG0516	GMP reductase activity
LK450_RS06950	COG0517	IMP dehydrogenase activity
LK450_RS06955	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LK450_RS06965	COG0612	Peptidase, M16
LK450_RS06970	COG0612	Peptidase, M16
LK450_RS06980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LK450_RS06985	COG1122	ATPase activity
LK450_RS06990	COG1122	ATPase activity
LK450_RS06995	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
LK450_RS07010	COG1760	l-serine dehydratase
LK450_RS07015	COG1760	l-serine dehydratase
LK450_RS07025	COG0482	sulfurtransferase activity
LK450_RS07030	COG0445	tRNA wobble uridine modification
LK450_RS07045	COG0305	Participates in initiation and elongation during chromosome replication
LK450_RS07055	COG1011	Hydrolase
LK450_RS07145	COG1696	Membrane protein involved in D-alanine export
LK450_RS07150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LK450_RS07155	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LK450_RS07160	COG0561	phosphatase activity
LK450_RS07165	COG2094	Belongs to the DNA glycosylase MPG family
LK450_RS07170	COG2807	transmembrane transport
LK450_RS07195	COG0582	viral genome integration into host DNA
LK450_RS07250	COG4974	Belongs to the 'phage' integrase family
LK450_RS07305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LK450_RS07310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LK450_RS07330	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LK450_RS07335	COG1523	belongs to the glycosyl hydrolase 13 family
LK450_RS07340	COG1609	Transcriptional regulator
LK450_RS07345	COG5521	maltodextrose utilization protein MalA
LK450_RS07350	COG3833	ABC-type maltose transport systems, permease component
LK450_RS07355	COG1175	transmembrane transport
LK450_RS07360	COG2182	Extracellular solute-binding protein
LK450_RS07365	COG1640	4-alpha-glucanotransferase
LK450_RS07370	COG0058	SHG alpha-glucan phosphorylase activity
LK450_RS07380	COG1780	Probably involved in ribonucleotide reductase function
LK450_RS07385	COG0018	arginyl-trna synthetase
LK450_RS07390	COG1438	arginine binding
LK450_RS07395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LK450_RS07410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LK450_RS07420	COG0632	four-way junction helicase activity
LK450_RS07425	COG0519	Catalyzes the synthesis of GMP from XMP
LK450_RS07435	COG1546	Belongs to the CinA family
LK450_RS07435	COG1058	Belongs to the CinA family
LK450_RS07440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LK450_RS07445	COG1393	Belongs to the ArsC family
LK450_RS07460	COG4472	Bacterial protein of unknown function (DUF965)
LK450_RS07465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LK450_RS07470	COG3906	Belongs to the UPF0473 family
LK450_RS07475	COG0285	dihydrofolate synthase activity
LK450_RS07485	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LK450_RS07515	COG0602	queuosine metabolic process
LK450_RS07525	COG4464	protein tyrosine phosphatase activity
LK450_RS07530	COG3944	biosynthesis protein
LK450_RS07550	COG0438	transferase activity, transferring glycosyl groups
LK450_RS07555	COG1045	serine acetyltransferase
LK450_RS07560	COG1442	glycosyl transferase family 8
LK450_RS07560	COG1216	Glycosyl transferase, family 2
LK450_RS07570	COG0438	transferase activity, transferring glycosyl groups
LK450_RS07585	COG0562	UDP-galactopyranose mutase
LK450_RS07605	COG5002	protein histidine kinase activity
LK450_RS07610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK450_RS07610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LK450_RS07615	COG1832	CoA-binding protein
LK450_RS07630	COG0343	queuine tRNA-ribosyltransferase activity
LK450_RS07645	COG0051	transcription antitermination factor activity, RNA binding
LK450_RS07650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LK450_RS07655	COG0088	Forms part of the polypeptide exit tunnel
LK450_RS07660	COG0089	rRNA binding
LK450_RS07665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LK450_RS07675	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LK450_RS07680	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LK450_RS07685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LK450_RS07690	COG0255	Belongs to the universal ribosomal protein uL29 family
LK450_RS07700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LK450_RS07705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LK450_RS07710	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LK450_RS07715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LK450_RS07720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LK450_RS07725	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LK450_RS07735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LK450_RS07740	COG1841	ribosomal large subunit assembly
LK450_RS07745	COG0200	Binds to the 23S rRNA
LK450_RS07750	COG0201	protein transport
LK450_RS07755	COG0563	adenylate kinase activity
LK450_RS07760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LK450_RS07765	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LK450_RS07770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LK450_RS07775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LK450_RS07780	COG0202	RNA polymerase activity
LK450_RS07785	COG0203	ribosomal protein L17
LK450_RS07795	COG0052	Belongs to the universal ribosomal protein uS2 family
LK450_RS07800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LK450_RS07820	COG4463	regulation of RNA biosynthetic process
LK450_RS07835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LK450_RS07840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LK450_RS07870	COG2190	(PTS) system
LK450_RS07870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK450_RS07870	COG1263	PTS System
LK450_RS07875	COG2190	(PTS) system
LK450_RS07875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK450_RS07875	COG1263	PTS System
LK450_RS07880	COG2723	6-phospho-beta-galactosidase activity
LK450_RS07900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LK450_RS07940	COG0166	Belongs to the GPI family
LK450_RS07950	COG0594	ribonuclease P activity
LK450_RS07970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
LK450_RS08025	COG0582	viral genome integration into host DNA
LK450_RS08030	COG0084	hydrolase, TatD family'
LK450_RS08045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LK450_RS08060	COG1162	GTPase activity
LK450_RS08070	COG1564	THIamine pyrophosphokinase
LK450_RS08080	COG3481	metal-dependent phosphohydrolase, HD sub domain
LK450_RS08085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LK450_RS08095	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LK450_RS08100	COG0049	tRNA binding
LK450_RS08105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LK450_RS08125	COG1214	PFAM Peptidase M22, glycoprotease
LK450_RS08150	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LK450_RS08155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LK450_RS08160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LK450_RS08170	COG0756	dUTP diphosphatase activity
LK450_RS08180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LK450_RS08185	COG2171	N-acyltransferase activity
LK450_RS08190	COG1473	amidohydrolase
LK450_RS08195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LK450_RS08205	COG0500	methyltransferase
LK450_RS08210	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LK450_RS08220	COG0085	RNA polymerase activity
LK450_RS08225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LK450_RS08230	COG0126	phosphoglycerate kinase activity
LK450_RS08240	COG0789	Transcriptional regulator
LK450_RS08245	COG0174	glutamine synthetase
LK450_RS08255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LK450_RS08260	COG1459	type II secretion system
LK450_RS08265	COG4537	Required for transformation and DNA binding
LK450_RS08295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LK450_RS08310	COG3037	sugar-specific permease SgaT UlaA
LK450_RS08320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LK450_RS08330	COG3623	hexulose-6-phosphate isomerase
LK450_RS08350	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LK450_RS08355	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
LK450_RS08365	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LK450_RS08370	COG4589	Belongs to the CDS family
LK450_RS08375	COG0750	zinc metalloprotease
LK450_RS08380	COG0442	prolyl-tRNA aminoacylation
LK450_RS08390	COG0285	dihydrofolate synthase activity
LK450_RS08400	COG1363	Peptidase, m42
LK450_RS08410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LK450_RS08415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LK450_RS08430	COG4585	Histidine kinase
LK450_RS08435	COG2197	response regulator
LK450_RS08455	COG3715	PTS system
LK450_RS08460	COG3716	PTS system mannose fructose sorbose family IID component
LK450_RS08470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LK450_RS08475	COG0459	protein refolding
LK450_RS08490	COG1428	Deoxynucleoside kinase
LK450_RS08495	COG1418	mRNA catabolic process
LK450_RS08515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LK450_RS08535	COG2264	protein methyltransferase activity
LK450_RS08540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LK450_RS08555	COG1490	D-aminoacyl-tRNA deacylase activity
LK450_RS08580	COG3590	peptidase
LK450_RS08590	COG0495	leucyl-tRNA aminoacylation
LK450_RS08595	COG0561	phosphatase activity
LK450_RS08600	COG1609	Transcriptional regulator
LK450_RS08620	COG1523	belongs to the glycosyl hydrolase 13 family
LK450_RS08625	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LK450_RS08635	COG2176	DNA-directed DNA polymerase activity
LK450_RS08670	COG1187	pseudouridine synthase activity
LK450_RS08685	COG3118	belongs to the thioredoxin family
LK450_RS08700	COG1164	Oligoendopeptidase f
LK450_RS08705	COG1185	polyribonucleotide nucleotidyltransferase activity
LK450_RS08710	COG1045	serine acetyltransferase
LK450_RS08715	COG0215	cysteine-tRNA ligase activity
LK450_RS08720	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LK450_RS08730	COG3842	ATPase activity
LK450_RS08750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LK450_RS08755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LK450_RS08770	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LK450_RS08780	COG1215	transferase activity, transferring glycosyl groups
LK450_RS08785	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LK450_RS08805	COG3830	Belongs to the UPF0237 family
LK450_RS08810	COG2848	UPF0210 protein
LK450_RS08815	COG0588	phosphoglycerate mutase activity
LK450_RS08820	COG0588	phosphoglycerate mutase activity
LK450_RS08835	COG1420	regulation of RNA biosynthetic process
LK450_RS08840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LK450_RS08845	COG0443	Heat shock 70 kDa protein
LK450_RS08855	COG0484	heat shock protein binding
LK450_RS08865	COG0101	tRNA pseudouridine synthase activity
LK450_RS08870	COG0351	phosphomethylpyrimidine kinase
LK450_RS08875	COG4720	Psort location CytoplasmicMembrane, score
LK450_RS08880	COG4475	Protein of unknown function (DUF436)
LK450_RS08885	COG0544	peptidyl-prolyl cis-trans isomerase activity
LK450_RS08890	COG3343	RNA polymerase activity
LK450_RS08895	COG0504	CTP synthase activity
LK450_RS08905	COG4166	transmembrane transport
LK450_RS08910	COG4166	transmembrane transport
LK450_RS08915	COG0601	transmembrane transport
LK450_RS08920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LK450_RS08925	COG0444	Belongs to the ABC transporter superfamily
LK450_RS08930	COG4608	Belongs to the ABC transporter superfamily
LK450_RS08935	COG0561	phosphatase activity
LK450_RS08940	COG1609	Transcriptional regulator
LK450_RS08945	COG1621	beta-fructofuranosidase activity
LK450_RS08950	COG1263	PTS System
LK450_RS08950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LK450_RS08950	COG2190	(PTS) system
LK450_RS08955	COG1940	carbohydrate kinase activity
LK450_RS08960	COG0242	peptide deformylase activity
LK450_RS08975	COG1132	(ABC) transporter
LK450_RS08980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LK450_RS08985	COG1447	Phosphotransferase system cellobiose-specific component IIA
LK450_RS08990	COG2723	6-phospho-beta-galactosidase activity
LK450_RS08995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LK450_RS09000	COG2188	Transcriptional regulator
LK450_RS09005	COG1482	cell wall glycoprotein biosynthetic process
LK450_RS09010	COG0531	amino acid
LK450_RS09020	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LK450_RS09025	COG0736	holo-[acyl-carrier-protein] synthase activity
LK450_RS09030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LK450_RS09035	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LK450_RS09040	COG0252	asparaginase activity
LK450_RS09045	COG0561	phosphatase activity
LK450_RS09050	COG0589	response to stress
LK450_RS09055	COG0436	Aminotransferase
LK450_RS09060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LK450_RS09065	COG1335	isochorismatase
LK450_RS09070	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LK450_RS09110	COG3620	sequence-specific DNA binding
LK450_RS09170	COG1388	LysM domain
LK450_RS09170	COG3942	CHAP domain
LK450_RS09215	COG3843	relaxase mobilization nuclease domain protein