locus-tag	class	description
GE021_RS00010	COG0592	DNA-directed DNA polymerase activity
GE021_RS00025	COG0012	GTP binding
GE021_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GE021_RS00040	COG2244	polysaccharide biosynthetic process
GE021_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GE021_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GE021_RS00080	COG0531	amino acid
GE021_RS00210	COG1792	Involved in formation and maintenance of cell shape
GE021_RS00220	COG3942	CHAP domain
GE021_RS00235	COG0416	fatty acid biosynthetic process
GE021_RS00240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GE021_RS00250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GE021_RS00255	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GE021_RS00265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GE021_RS00270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GE021_RS00280	COG3942	CHAP domain
GE021_RS00285	COG0151	Belongs to the GarS family
GE021_RS00290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GE021_RS00300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GE021_RS00315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GE021_RS00330	COG1454	alcohol dehydrogenase
GE021_RS00330	COG1012	belongs to the aldehyde dehydrogenase family
GE021_RS00335	COG1064	alcohol dehydrogenase
GE021_RS00355	COG0051	transcription antitermination factor activity, RNA binding
GE021_RS00455	COG0200	Binds to the 23S rRNA
GE021_RS00460	COG0201	protein transport
GE021_RS00480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GE021_RS00590	COG0582	viral genome integration into host DNA
GE021_RS00625	COG1674	ftsk spoiiie
GE021_RS00670	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
GE021_RS00685	COG1271	oxidase subunit
GE021_RS00690	COG1294	oxidase, subunit
GE021_RS00695	COG4988	ABC transporter
GE021_RS00700	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GE021_RS00705	COG0142	geranyltranstransferase activity
GE021_RS00720	COG1121	(ABC) transporter
GE021_RS00725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GE021_RS00795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE021_RS00795	COG4499	WXG100 protein secretion system (Wss), protein YukC
GE021_RS00815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GE021_RS00820	COG1459	type II secretion system
GE021_RS00825	COG4537	Required for transformation and DNA binding
GE021_RS00850	COG2890	protein-(glutamine-N5) methyltransferase activity
GE021_RS00870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GE021_RS00875	COG1363	Peptidase, m42
GE021_RS00885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GE021_RS00890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GE021_RS00900	COG1428	Deoxynucleoside kinase
GE021_RS00905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GE021_RS00950	COG2031	fatty acid transporter
GE021_RS00960	COG0183	Belongs to the thiolase family
GE021_RS00965	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GE021_RS00980	COG0251	oxidation-reduction process
GE021_RS00995	COG1269	ATP hydrolysis coupled proton transport
GE021_RS01000	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GE021_RS01010	COG1527	subunit (C
GE021_RS01015	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
GE021_RS01050	COG1744	ABC transporter substrate-binding protein PnrA-like
GE021_RS01055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GE021_RS01060	COG1349	DNA-binding transcription factor activity
GE021_RS01065	COG2390	Transcriptional regulator
GE021_RS01075	COG1447	Phosphotransferase system cellobiose-specific component IIA
GE021_RS01080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE021_RS01085	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE021_RS01090	COG1882	Formate acetyltransferase
GE021_RS01100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GE021_RS01100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GE021_RS01100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GE021_RS01105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GE021_RS01110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GE021_RS01115	COG1882	Formate acetyltransferase
GE021_RS01120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GE021_RS01140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GE021_RS01170	COG2205	protein histidine kinase activity
GE021_RS01185	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GE021_RS01190	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GE021_RS01195	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GE021_RS01240	COG2207	Transcriptional regulator
GE021_RS01250	COG1175	transmembrane transport
GE021_RS01255	COG0395	ABC-type sugar transport system, permease component
GE021_RS01270	COG2017	converts alpha-aldose to the beta-anomer
GE021_RS01275	COG1609	Transcriptional regulator
GE021_RS01280	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GE021_RS01285	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GE021_RS01290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GE021_RS01320	COG3620	sequence-specific DNA binding
GE021_RS01370	COG1674	ftsk spoiiie
GE021_RS01375	COG2946	Replication initiation factor
GE021_RS01420	COG4115	mRNA cleavage
GE021_RS01440	COG0433	COG0433 Predicted ATPase
GE021_RS01490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GE021_RS01495	COG0512	Glutamine amidotransferase of anthranilate synthase
GE021_RS01500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GE021_RS01525	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GE021_RS01530	COG1609	Transcriptional regulator
GE021_RS01535	COG2190	(PTS) system
GE021_RS01535	COG1263	PTS System
GE021_RS01535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE021_RS01550	COG1363	Peptidase, m42
GE021_RS01590	COG3842	ATPase activity
GE021_RS01600	COG1523	belongs to the glycosyl hydrolase 13 family
GE021_RS01615	COG1862	Preprotein translocase
GE021_RS01625	COG4589	Belongs to the CDS family
GE021_RS01655	COG1846	Transcriptional regulator
GE021_RS01700	COG1126	abc transporter atp-binding protein
GE021_RS01725	COG3037	sugar-specific permease SgaT UlaA
GE021_RS01730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GE021_RS01745	COG1045	serine acetyltransferase
GE021_RS01760	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GE021_RS01775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GE021_RS01795	COG1476	TRANSCRIPTIONal
GE021_RS01800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GE021_RS01885	COG0351	phosphomethylpyrimidine kinase
GE021_RS01890	COG4720	Psort location CytoplasmicMembrane, score
GE021_RS01900	COG0668	transmembrane transport
GE021_RS01910	COG3343	RNA polymerase activity
GE021_RS01925	COG3279	Response regulator of the LytR AlgR family
GE021_RS01935	COG1346	cytolysis
GE021_RS01990	COG0765	amino acid transport
GE021_RS02015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GE021_RS02025	COG0719	Fe-S assembly protein
GE021_RS02030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GE021_RS02045	COG1686	Belongs to the peptidase S11 family
GE021_RS02050	COG1686	Belongs to the peptidase S11 family
GE021_RS02055	COG4166	transmembrane transport
GE021_RS02060	COG0601	transmembrane transport
GE021_RS02065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE021_RS02070	COG0444	Belongs to the ABC transporter superfamily
GE021_RS02135	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GE021_RS02140	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GE021_RS02145	COG1534	Rna-binding protein
GE021_RS02155	COG1713	HD superfamily hydrolase involved in NAD metabolism
GE021_RS02165	COG0799	negative regulation of ribosome biogenesis
GE021_RS02170	COG2226	methyltransferase
GE021_RS02175	COG1323	Belongs to the UPF0348 family
GE021_RS02180	COG0789	Transcriptional regulator
GE021_RS02190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE021_RS02195	COG1464	Belongs to the NlpA lipoprotein family
GE021_RS02215	COG1114	Component of the transport system for branched-chain amino acids
GE021_RS02225	COG0569	domain protein
GE021_RS02230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GE021_RS02240	COG1704	LemA family
GE021_RS02245	COG0501	Belongs to the peptidase M48B family
GE021_RS02255	COG0745	RESPONSE REGULATOR receiver
GE021_RS02260	COG5002	protein histidine kinase activity
GE021_RS02265	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GE021_RS02275	COG1484	DNA-dependent DNA replication
GE021_RS02285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GE021_RS02305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GE021_RS02325	COG1254	Belongs to the acylphosphatase family
GE021_RS02335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GE021_RS02390	COG1187	pseudouridine synthase activity
GE021_RS02415	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GE021_RS02420	COG0671	phosphoesterase, PA-phosphatase related
GE021_RS02425	COG1242	4 iron, 4 sulfur cluster binding
GE021_RS02430	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GE021_RS02435	COG1253	flavin adenine dinucleotide binding
GE021_RS02440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GE021_RS02455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE021_RS02460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE021_RS02465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GE021_RS02470	COG1120	ATPase activity
GE021_RS02480	COG2244	polysaccharide biosynthetic process
GE021_RS02515	COG0470	DNA polymerase III
GE021_RS02520	COG1774	PSP1 C-terminal conserved region
GE021_RS02550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GE021_RS02555	COG1393	Belongs to the ArsC family
GE021_RS02570	COG1609	Transcriptional regulator
GE021_RS02575	COG0561	phosphatase activity
GE021_RS02580	COG0708	Exodeoxyribonuclease III
GE021_RS02595	COG1620	l-lactate permease
GE021_RS02600	COG1304	FMN binding
GE021_RS02645	COG1114	Component of the transport system for branched-chain amino acids
GE021_RS02665	COG1028	Short-chain dehydrogenase reductase Sdr
GE021_RS02680	COG0673	inositol 2-dehydrogenase activity
GE021_RS02705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GE021_RS02800	COG1702	phosphate starvation-inducible protein PhoH
GE021_RS02805	COG1573	uracil-dna glycosylase
GE021_RS02815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GE021_RS02845	COG1396	sequence-specific DNA binding
GE021_RS02860	COG1131	(ABC) transporter
GE021_RS02880	COG0433	COG0433 Predicted ATPase
GE021_RS02885	COG2814	Major facilitator Superfamily
GE021_RS02900	COG0557	exoribonuclease II activity
GE021_RS02910	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GE021_RS02920	COG0463	Glycosyl transferase, family 2
GE021_RS02925	COG0346	lactoylglutathione lyase activity
GE021_RS02930	COG0778	Nitroreductase
GE021_RS02940	COG1609	Transcriptional regulator
GE021_RS02955	COG0438	transferase activity, transferring glycosyl groups
GE021_RS02990	COG2376	Dihydroxyacetone kinase
GE021_RS03000	COG2376	Dihydroxyacetone kinase
GE021_RS03005	COG1461	Dihydroxyacetone kinase
GE021_RS03010	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GE021_RS03015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GE021_RS03025	COG0745	RESPONSE REGULATOR receiver
GE021_RS03030	COG5002	protein histidine kinase activity
GE021_RS03035	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GE021_RS03045	COG1196	nuclear chromosome segregation
GE021_RS03055	COG0561	phosphatase activity
GE021_RS03060	COG0561	phosphatase activity
GE021_RS03065	COG0552	protein localization to endoplasmic reticulum
GE021_RS03070	COG0477	Major facilitator Superfamily
GE021_RS03075	COG3711	transcriptional antiterminator
GE021_RS03080	COG2190	(PTS) system
GE021_RS03080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE021_RS03080	COG1263	PTS System
GE021_RS03090	COG3689	TIGRFAM TIGR03943 family protein
GE021_RS03095	COG0701	Predicted permease
GE021_RS03125	COG2183	response to ionizing radiation
GE021_RS03185	COG4443	Transcriptional Coactivator p15 (PC4)
GE021_RS03190	COG2801	Transposase and inactivated derivatives
GE021_RS03215	COG2801	Transposase and inactivated derivatives
GE021_RS03220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GE021_RS03250	COG0386	Belongs to the glutathione peroxidase family
GE021_RS03255	COG1164	Oligoendopeptidase f
GE021_RS03265	COG0772	Belongs to the SEDS family
GE021_RS03310	COG1215	transferase activity, transferring glycosyl groups
GE021_RS03330	COG2348	transferase activity, transferring amino-acyl groups
GE021_RS03340	COG1078	dGTPase activity
GE021_RS03375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GE021_RS03380	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GE021_RS03385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GE021_RS03395	COG2884	Cell division ATP-binding protein ftsE
GE021_RS03400	COG2177	Part of the ABC transporter FtsEX involved in
GE021_RS03410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GE021_RS03410	COG1199	ATP-dependent helicase activity
GE021_RS03415	COG0436	Aminotransferase
GE021_RS03420	COG0017	Asparaginyl-tRNA synthetase
GE021_RS03455	COG2188	Transcriptional regulator
GE021_RS03460	COG2222	sugar isomerase
GE021_RS03485	COG3715	PTS system
GE021_RS03490	COG3716	PTS system mannose fructose sorbose family IID component
GE021_RS03505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GE021_RS03510	COG2153	protein acetylation
GE021_RS03525	COG0716	FMN binding
GE021_RS03535	COG0038	chloride channel
GE021_RS03605	COG0772	Belongs to the SEDS family
GE021_RS03670	COG1131	(ABC) transporter
GE021_RS03690	COG4708	membrane
GE021_RS03700	COG1597	lipid kinase activity
GE021_RS03705	COG1523	belongs to the glycosyl hydrolase 13 family
GE021_RS03710	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GE021_RS03715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GE021_RS03720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GE021_RS03725	COG0297	glycogen (starch) synthase activity
GE021_RS03800	COG2801	Transposase and inactivated derivatives
GE021_RS03835	COG0436	Aminotransferase
GE021_RS03840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE021_RS03850	COG1970	mechanosensitive ion channel activity
GE021_RS03855	COG0358	DNA primase activity
GE021_RS03860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GE021_RS03865	COG2151	metal-sulfur cluster biosynthetic enzyme
GE021_RS03935	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GE021_RS03955	COG0860	N-Acetylmuramoyl-L-alanine amidase
GE021_RS04000	COG1368	sulfuric ester hydrolase activity
GE021_RS04005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GE021_RS04025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GE021_RS04030	COG0285	dihydrofolate synthase activity
GE021_RS04040	COG1104	cysteine desulfurase activity
GE021_RS04065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GE021_RS04070	COG0583	DNA-binding transcription factor activity
GE021_RS04080	COG0564	pseudouridine synthase activity
GE021_RS04120	COG1136	(ABC) transporter
GE021_RS04125	COG0577	efflux transmembrane transporter activity
GE021_RS04135	COG0584	glycerophosphoryl diester phosphodiesterase
GE021_RS04145	COG1837	Belongs to the UPF0109 family
GE021_RS04175	COG1349	DNA-binding transcription factor activity
GE021_RS04180	COG1105	Belongs to the carbohydrate kinase PfkB family
GE021_RS04185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GE021_RS04185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GE021_RS04185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GE021_RS04190	COG1388	LysM domain
GE021_RS04190	COG1705	Flagellar rod assembly protein muramidase FlgJ
GE021_RS04195	COG1705	Flagellar rod assembly protein muramidase FlgJ
GE021_RS04195	COG1388	LysM domain
GE021_RS04220	COG0488	(ABC) transporter
GE021_RS04225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GE021_RS04230	COG0242	peptide deformylase activity
GE021_RS04235	COG0737	Belongs to the 5'-nucleotidase family
GE021_RS04240	COG1132	(ABC) transporter
GE021_RS04245	COG1132	(ABC) transporter
GE021_RS04285	COG3425	synthase
GE021_RS04295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GE021_RS04440	COG0270	DNA (cytosine-5-)-methyltransferase activity
GE021_RS04485	COG0582	viral genome integration into host DNA
GE021_RS04520	COG0740	serine-type endopeptidase activity
GE021_RS04675	COG3715	PTS system
GE021_RS04680	COG3716	PTS system mannose fructose sorbose family IID component
GE021_RS04690	COG2207	Transcriptional regulator
GE021_RS04690	COG4753	response regulator
GE021_RS04695	COG1840	ABC-type Fe3 transport system, periplasmic component
GE021_RS04710	COG1011	Hydrolase
GE021_RS04715	COG1012	belongs to the aldehyde dehydrogenase family
GE021_RS04730	COG0028	Belongs to the TPP enzyme family
GE021_RS04740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GE021_RS04770	COG0398	Pfam SNARE associated Golgi protein
GE021_RS04780	COG1131	(ABC) transporter
GE021_RS04785	COG1725	Transcriptional regulator
GE021_RS04800	COG0469	pyruvate kinase activity
GE021_RS04820	COG2824	Alkylphosphonate utilization operon protein PhnA
GE021_RS04825	COG0765	amino acid transport
GE021_RS04830	COG1126	abc transporter atp-binding protein
GE021_RS04835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE021_RS04845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GE021_RS04850	COG1115	amino acid carrier protein
GE021_RS04860	COG2261	transglycosylase associated protein
GE021_RS04900	COG4591	ABC-type transport system involved in lipoprotein release permease component
GE021_RS04900	COG1136	(ABC) transporter
GE021_RS04930	COG0196	riboflavin kinase activity
GE021_RS04945	COG0483	inositol monophosphate 1-phosphatase activity
GE021_RS04950	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GE021_RS04950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GE021_RS04960	COG0573	inorganic phosphate transmembrane transporter activity
GE021_RS04965	COG0581	inorganic phosphate transmembrane transporter activity
GE021_RS04980	COG0704	Plays a role in the regulation of phosphate uptake
GE021_RS04995	COG0745	RESPONSE REGULATOR receiver
GE021_RS05000	COG5002	protein histidine kinase activity
GE021_RS05015	COG2813	Specifically methylates the guanine in position
GE021_RS05020	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GE021_RS05035	COG1744	ABC transporter substrate-binding protein PnrA-like
GE021_RS05055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GE021_RS05060	COG4684	Psort location CytoplasmicMembrane, score
GE021_RS05065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GE021_RS05070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GE021_RS05075	COG0095	Lipoate-protein ligase
GE021_RS05085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE021_RS05120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GE021_RS05125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GE021_RS05125	COG1328	CTP reductase activity
GE021_RS05130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GE021_RS05145	COG0488	(ABC) transporter
GE021_RS05165	COG1272	protein, Hemolysin III
GE021_RS05185	COG0758	DNA mediated transformation
GE021_RS05190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GE021_RS05220	COG0511	ligase activity, forming carbon-carbon bonds
GE021_RS05225	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GE021_RS05245	COG2851	Citrate transporter
GE021_RS05255	COG0511	ligase activity, forming carbon-carbon bonds
GE021_RS05260	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
GE021_RS05290	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
GE021_RS05295	COG2267	carboxylic ester hydrolase activity
GE021_RS05300	COG0392	lysyltransferase activity
GE021_RS05300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GE021_RS05315	COG1136	(ABC) transporter
GE021_RS05320	COG0577	efflux transmembrane transporter activity
GE021_RS05325	COG0745	RESPONSE REGULATOR receiver
GE021_RS05330	COG5002	protein histidine kinase activity
GE021_RS05340	COG1252	NADH dehydrogenase
GE021_RS05345	COG0142	geranyltranstransferase activity
GE021_RS05350	COG4939	FMN-binding domain protein
GE021_RS05390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GE021_RS05400	COG2188	Transcriptional regulator
GE021_RS05440	COG1396	sequence-specific DNA binding
GE021_RS05460	COG0803	Belongs to the bacterial solute-binding protein 9 family
GE021_RS05475	COG0803	Belongs to the bacterial solute-binding protein 9 family
GE021_RS05490	COG0346	lactoylglutathione lyase activity
GE021_RS05495	COG3764	Sortase (surface protein transpeptidase)
GE021_RS05540	COG2890	protein-(glutamine-N5) methyltransferase activity
GE021_RS05565	COG2233	PERMEase
GE021_RS05580	COG1174	glycine betaine transport
GE021_RS05595	COG4221	oxidoreductase activity
GE021_RS05600	COG0280	phosphate acetyltransferase
GE021_RS05605	COG0564	pseudouridine synthase activity
GE021_RS05615	COG2357	RelA SpoT domain protein
GE021_RS05630	COG1104	cysteine desulfurase activity
GE021_RS05650	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GE021_RS05660	COG0628	permease
GE021_RS05670	COG2207	Transcriptional regulator
GE021_RS05685	COG1177	transmembrane transport
GE021_RS05690	COG1176	ABC-type spermidine putrescine transport system, permease component I
GE021_RS05705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GE021_RS05720	COG0302	gtp cyclohydrolase
GE021_RS05725	COG0285	dihydrofolate synthase activity
GE021_RS05760	COG0539	negative regulation of cytoplasmic translation
GE021_RS05780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GE021_RS05795	COG0187	DNA topoisomerase II activity
GE021_RS05815	COG0765	amino acid transport
GE021_RS05820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE021_RS05930	COG4974	Belongs to the 'phage' integrase family
GE021_RS05940	COG1396	sequence-specific DNA binding
GE021_RS05955	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE021_RS05955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE021_RS05965	COG3711	transcriptional antiterminator
GE021_RS05970	COG3684	Belongs to the aldolase LacD family
GE021_RS05975	COG1105	Belongs to the carbohydrate kinase PfkB family
GE021_RS05980	COG0698	ribose 5-phosphate isomerase
GE021_RS05985	COG0698	ribose 5-phosphate isomerase
GE021_RS05990	COG1349	DNA-binding transcription factor activity
GE021_RS05995	COG3843	relaxase mobilization nuclease domain protein
GE021_RS06080	COG4443	Transcriptional Coactivator p15 (PC4)
GE021_RS06085	COG1475	DNA binding
GE021_RS06235	COG0270	DNA (cytosine-5-)-methyltransferase activity
GE021_RS06270	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GE021_RS06275	COG1518	maintenance of DNA repeat elements
GE021_RS06290	COG0647	UMP catabolic process
GE021_RS06300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GE021_RS06320	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GE021_RS06325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GE021_RS06330	COG3442	glutamine amidotransferase
GE021_RS06335	COG0095	Lipoate-protein ligase
GE021_RS06355	COG0508	dehydrogenase complex catalyzes the overall conversion of
GE021_RS06360	COG0508	dehydrogenase complex catalyzes the overall conversion of
GE021_RS06360	COG0022	dehydrogenase e1 component
GE021_RS06365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GE021_RS06370	COG0488	(ABC) transporter
GE021_RS06390	COG1122	ATPase activity
GE021_RS06410	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GE021_RS06420	COG0457	Tetratricopeptide repeat
GE021_RS06425	COG0628	permease
GE021_RS06430	COG1051	belongs to the nudix hydrolase family
GE021_RS06435	COG2706	6-phosphogluconolactonase activity
GE021_RS06445	COG1088	dTDP-glucose 4,6-dehydratase activity
GE021_RS06455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GE021_RS06460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GE021_RS06475	COG2384	SAM-dependent methyltransferase
GE021_RS06480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GE021_RS06495	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GE021_RS06495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GE021_RS06500	COG0300	oxidoreductase activity
GE021_RS06510	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GE021_RS06515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GE021_RS06565	COG0058	SHG alpha-glucan phosphorylase activity
GE021_RS06570	COG1640	4-alpha-glucanotransferase
GE021_RS06575	COG1609	Transcriptional regulator
GE021_RS06580	COG2182	Extracellular solute-binding protein
GE021_RS06585	COG1175	transmembrane transport
GE021_RS06590	COG3833	ABC-type maltose transport systems, permease component
GE021_RS06595	COG1609	Transcriptional regulator
GE021_RS06610	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GE021_RS06620	COG1696	Membrane protein involved in D-alanine export
GE021_RS06635	COG0556	nucleotide-excision repair
GE021_RS06640	COG0765	amino acid transport
GE021_RS06645	COG1126	abc transporter atp-binding protein
GE021_RS06660	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE021_RS06670	COG1447	Phosphotransferase system cellobiose-specific component IIA
GE021_RS06680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GE021_RS06680	COG3711	transcriptional antiterminator
GE021_RS06690	COG2723	6-phospho-beta-galactosidase activity
GE021_RS06720	COG2309	aminopeptidase activity
GE021_RS06730	COG1187	pseudouridine synthase activity
GE021_RS06740	COG2814	Major facilitator Superfamily
GE021_RS06765	COG1464	Belongs to the NlpA lipoprotein family
GE021_RS06790	COG1940	carbohydrate kinase activity
GE021_RS06795	COG1447	Phosphotransferase system cellobiose-specific component IIA
GE021_RS06810	COG3328	transposase activity
GE021_RS06815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE021_RS06845	COG1316	TRANSCRIPTIONal
GE021_RS06870	COG4109	DRTGG domain
GE021_RS06880	COG2186	Transcriptional regulator
GE021_RS06905	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GE021_RS06905	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GE021_RS06915	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GE021_RS06935	COG0513	Belongs to the DEAD box helicase family
GE021_RS06940	COG0726	polysaccharide deacetylase
GE021_RS06945	COG1012	belongs to the aldehyde dehydrogenase family
GE021_RS06960	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GE021_RS06965	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GE021_RS06970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GE021_RS06990	COG1476	TRANSCRIPTIONal
GE021_RS07005	COG4122	O-methyltransferase activity
GE021_RS07010	COG2223	nitrite transmembrane transporter activity
GE021_RS07020	COG0546	phosphoglycolate phosphatase activity
GE021_RS07050	COG1187	pseudouridine synthase activity
GE021_RS07085	COG0658	competence protein
GE021_RS07085	COG2333	competence protein COMEC
GE021_RS07090	COG1555	photosystem II stabilization
GE021_RS07090	COG1596	polysaccharide export
GE021_RS07095	COG0204	Acyl-transferase
GE021_RS07100	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GE021_RS07115	COG0513	Belongs to the DEAD box helicase family
GE021_RS07125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GE021_RS07145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GE021_RS07160	COG0768	penicillin binding
GE021_RS07165	COG2116	formate transmembrane transporter activity
GE021_RS07175	COG1827	regulation of RNA biosynthetic process
GE021_RS07195	COG2217	Heavy metal translocating P-type atpase
GE021_RS07220	COG2755	lipolytic protein G-D-S-L family
GE021_RS07240	COG0497	DNA recombination
GE021_RS07245	COG1438	arginine binding
GE021_RS07250	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GE021_RS07270	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GE021_RS07280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GE021_RS07295	COG1378	Sugar-specific transcriptional regulator TrmB
GE021_RS07320	COG0765	amino acid transport
GE021_RS07330	COG4703	Protein of unknown function (DUF1797)
GE021_RS07335	COG0542	response to heat
GE021_RS07355	COG3599	regulation of cell shape
GE021_RS07375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GE021_RS07425	COG1940	carbohydrate kinase activity
GE021_RS07435	COG0783	Belongs to the Dps family
GE021_RS07445	COG1132	(ABC) transporter
GE021_RS07450	COG1132	(ABC) transporter
GE021_RS07460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GE021_RS07465	COG4470	Protein conserved in bacteria
GE021_RS07470	COG1879	ABC-type sugar transport system periplasmic component
GE021_RS07480	COG1172	Belongs to the binding-protein-dependent transport system permease family
GE021_RS07490	COG1869	D-ribose catabolic process
GE021_RS07495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GE021_RS07500	COG1609	Transcriptional regulator
GE021_RS07505	COG3480	Lon protease (S16) C-terminal proteolytic domain
GE021_RS07515	COG0742	ribosomal rna small subunit methyltransferase
GE021_RS07530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GE021_RS07535	COG1288	antiporter activity
GE021_RS07545	COG0454	-acetyltransferase
GE021_RS07550	COG2235	arginine
GE021_RS07575	COG2972	Histidine kinase
GE021_RS07590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GE021_RS07595	COG0785	Cytochrome C biogenesis protein
GE021_RS07600	COG0673	inositol 2-dehydrogenase activity
GE021_RS07640	COG0346	lactoylglutathione lyase activity
GE021_RS07660	COG0534	Mate efflux family protein
GE021_RS07700	COG1605	Chorismate mutase
GE021_RS07700	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GE021_RS07715	COG3250	beta-galactosidase activity
GE021_RS07720	COG2207	Transcriptional regulator
GE021_RS07720	COG4753	response regulator
GE021_RS07725	COG2972	Histidine kinase
GE021_RS07740	COG0395	ABC-type sugar transport system, permease component
GE021_RS07745	COG1175	transmembrane transport
GE021_RS07765	COG2723	6-phospho-beta-galactosidase activity
GE021_RS07770	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GE021_RS07785	COG0383	alpha-mannosidase activity
GE021_RS07885	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GE021_RS07890	COG1739	Uncharacterized protein family UPF0029
GE021_RS07900	COG1098	S1 RNA binding domain
GE021_RS07910	COG2197	response regulator
GE021_RS07915	COG4585	Histidine kinase
GE021_RS07925	COG0515	serine threonine protein kinase
GE021_RS07925	COG2815	serine threonine protein kinase
GE021_RS07935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GE021_RS07935	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GE021_RS07945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GE021_RS07965	COG0183	Belongs to the thiolase family
GE021_RS07980	COG0116	Belongs to the methyltransferase superfamily
GE021_RS08005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE021_RS08010	COG3579	cysteine-type endopeptidase activity
GE021_RS08020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GE021_RS08025	COG1113	amino acid transport
GE021_RS08040	COG1126	abc transporter atp-binding protein
GE021_RS08045	COG0765	amino acid transport
GE021_RS08055	COG0513	Belongs to the DEAD box helicase family
GE021_RS08065	COG0768	penicillin binding
GE021_RS08100	COG1131	(ABC) transporter
GE021_RS08125	COG0446	pyridine nucleotide-disulphide oxidoreductase
GE021_RS08130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GE021_RS08165	COG1755	Isoprenylcysteine carboxyl methyltransferase
GE021_RS08190	COG0641	radical SAM
GE021_RS08210	COG3119	arylsulfatase activity
GE021_RS08220	COG3715	PTS system
GE021_RS08225	COG0366	Alpha amylase catalytic
GE021_RS08240	COG2801	Transposase and inactivated derivatives
GE021_RS08270	COG1283	sodium-dependent phosphate transmembrane transporter activity
GE021_RS08295	COG0561	phosphatase activity
GE021_RS08300	COG2860	membrane
GE021_RS08315	COG1105	Belongs to the carbohydrate kinase PfkB family
GE021_RS08355	COG2217	Heavy metal translocating P-type atpase
GE021_RS08395	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GE021_RS08400	COG0195	Participates in both transcription termination and antitermination
GE021_RS08425	COG4473	ABC transporter
GE021_RS08430	COG1131	(ABC) transporter
GE021_RS08435	COG0537	adenosine 5'-monophosphoramidase activity
GE021_RS08450	COG1316	TRANSCRIPTIONal
GE021_RS08455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GE021_RS08460	COG0802	atpase or kinase
GE021_RS08465	COG2252	PERMEase
GE021_RS08470	COG0561	phosphatase activity
GE021_RS08480	COG3715	PTS system
GE021_RS08485	COG3716	PTS system mannose fructose sorbose family IID component
GE021_RS08540	COG1484	DNA-dependent DNA replication
GE021_RS08550	COG4804	nuclease activity
GE021_RS08580	COG5002	protein histidine kinase activity
GE021_RS08615	COG3344	reverse transcriptase
GE021_RS08635	COG1484	DNA-dependent DNA replication
GE021_RS08675	COG0439	Biotin carboxylase
GE021_RS08690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GE021_RS08695	COG1028	Short-chain dehydrogenase reductase Sdr
GE021_RS08700	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GE021_RS08725	COG1024	Enoyl-CoA hydratase
GE021_RS08730	COG0484	heat shock protein binding
GE021_RS08735	COG0443	Heat shock 70 kDa protein
GE021_RS08745	COG1420	regulation of RNA biosynthetic process
GE021_RS08760	COG0588	phosphoglycerate mutase activity
GE021_RS08775	COG2261	transglycosylase associated protein
GE021_RS08780	COG0697	spore germination
GE021_RS08800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GE021_RS08800	COG0574	Belongs to the PEP-utilizing enzyme family
GE021_RS08805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GE021_RS08810	COG0517	IMP dehydrogenase activity
GE021_RS08815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GE021_RS08820	COG1335	isochorismatase
GE021_RS08830	COG0436	Aminotransferase
GE021_RS08840	COG0561	phosphatase activity
GE021_RS08845	COG0252	asparaginase activity
GE021_RS08850	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GE021_RS08855	COG1129	ABC transporter
GE021_RS08870	COG1132	(ABC) transporter
GE021_RS08875	COG4988	ABC transporter
GE021_RS08880	COG1120	ATPase activity
GE021_RS08905	COG1388	LysM domain
GE021_RS08905	COG3942	CHAP domain
GE021_RS08925	COG1482	cell wall glycoprotein biosynthetic process
GE021_RS08930	COG1940	carbohydrate kinase activity
GE021_RS08940	COG1263	PTS System
GE021_RS08940	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE021_RS08940	COG2190	(PTS) system
GE021_RS08945	COG1621	beta-fructofuranosidase activity
GE021_RS08950	COG1609	Transcriptional regulator
GE021_RS08970	COG2131	deaminase
GE021_RS08975	COG0006	proline dipeptidase activity
GE021_RS09020	COG1194	a g-specific adenine glycosylase
GE021_RS09025	COG3118	belongs to the thioredoxin family
GE021_RS09030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GE021_RS09055	COG0681	Belongs to the peptidase S26 family
GE021_RS09060	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GE021_RS09075	COG1882	Formate acetyltransferase
GE021_RS09085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GE021_RS09100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GE021_RS09145	COG0789	Transcriptional regulator
GE021_RS09160	COG2081	HI0933 family
GE021_RS09195	COG1214	PFAM Peptidase M22, glycoprotease
GE021_RS09210	COG4608	Belongs to the ABC transporter superfamily
GE021_RS09215	COG0444	Belongs to the ABC transporter superfamily
GE021_RS09220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE021_RS09225	COG0601	transmembrane transport
GE021_RS09230	COG4166	transmembrane transport
GE021_RS09235	COG0174	glutamine synthetase
GE021_RS09240	COG0789	Transcriptional regulator
GE021_RS09260	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GE021_RS09290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GE021_RS09305	COG1564	THIamine pyrophosphokinase
GE021_RS09325	COG2814	Major facilitator Superfamily
GE021_RS09335	COG1288	antiporter activity
GE021_RS09340	COG0549	Belongs to the carbamate kinase family
GE021_RS09345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GE021_RS09355	COG0784	Response regulator, receiver
GE021_RS09375	COG0084	hydrolase, TatD family'
GE021_RS09385	COG2814	Major facilitator Superfamily
GE021_RS09390	COG1335	isochorismatase
GE021_RS09400	COG2190	(PTS) system
GE021_RS09400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE021_RS09400	COG1263	PTS System
GE021_RS09460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GE021_RS09480	COG0673	inositol 2-dehydrogenase activity
GE021_RS09485	COG4409	exo-alpha-(2->6)-sialidase activity
GE021_RS09495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GE021_RS09500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GE021_RS09505	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GE021_RS09570	COG0542	response to heat
GE021_RS09665	COG0270	DNA (cytosine-5-)-methyltransferase activity
GE021_RS09750	COG0756	dUTP diphosphatase activity
GE021_RS09765	COG1132	(ABC) transporter
GE021_RS09770	COG1132	(ABC) transporter
GE021_RS09780	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GE021_RS09785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GE021_RS09790	COG0705	Rhomboid family
GE021_RS09790	COG0457	Tetratricopeptide repeat
GE021_RS09795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GE021_RS09835	COG1234	tRNA 3'-trailer cleavage
GE021_RS09840	COG1268	BioY protein
GE021_RS09850	COG0343	queuine tRNA-ribosyltransferase activity
GE021_RS09875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GE021_RS09875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GE021_RS09885	COG3448	diguanylate cyclase activity
GE021_RS09885	COG4175	Glycine betaine
GE021_RS09890	COG1597	lipid kinase activity
GE021_RS09920	COG3775	system Galactitol-specific IIC component
GE021_RS09925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GE021_RS09940	COG1609	Transcriptional regulator
GE021_RS09950	COG3623	hexulose-6-phosphate isomerase
GE021_RS09975	COG0495	leucyl-tRNA aminoacylation
GE021_RS10000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE021_RS10015	COG0564	pseudouridine synthase activity
GE021_RS10030	COG0494	nUDIX hydrolase
GE021_RS10055	COG0542	response to heat
GE021_RS10060	COG4463	regulation of RNA biosynthetic process
GE021_RS10110	COG0346	lactoylglutathione lyase activity
GE021_RS10115	COG0346	lactoylglutathione lyase activity
GE021_RS10120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GE021_RS10130	COG0450	alkyl hydroperoxide reductase
GE021_RS10145	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GE021_RS10160	COG3404	Formiminotransferase-cyclodeaminase
GE021_RS10175	COG0531	amino acid
GE021_RS10220	COG3590	peptidase
GE021_RS10225	COG0366	Alpha amylase catalytic
GE021_RS10230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE021_RS10230	COG1263	PTS System
GE021_RS10235	COG2188	Transcriptional regulator
GE021_RS10250	COG0602	queuosine metabolic process
GE021_RS10270	COG1328	CTP reductase activity
GE021_RS10425	COG1783	phage Terminase large subunit
GE021_RS10555	COG4472	Bacterial protein of unknown function (DUF965)
GE021_RS10560	COG1393	Belongs to the ArsC family
GE021_RS10580	COG0519	Catalyzes the synthesis of GMP from XMP
GE021_RS10600	COG0582	viral genome integration into host DNA
GE021_RS10605	COG3645	SOS response
GE021_RS10760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GE021_RS10765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GE021_RS10770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GE021_RS10880	COG1511	domain protein
GE021_RS10890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GE021_RS10900	COG0305	Participates in initiation and elongation during chromosome replication
GE021_RS10935	COG1760	l-serine dehydratase
GE021_RS10940	COG1760	l-serine dehydratase
GE021_RS10950	COG0741	lytic transglycosylase activity
GE021_RS10970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GE021_RS10980	COG0612	Peptidase, M16
GE021_RS10985	COG0612	Peptidase, M16
GE021_RS11005	COG0516	GMP reductase activity
GE021_RS11005	COG0517	IMP dehydrogenase activity
GE021_RS11015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GE021_RS11020	COG0488	(ABC) transporter
GE021_RS11025	COG4485	Bacterial membrane protein, YfhO
GE021_RS11055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain