locus-tag	class	description
GE022_RS00010	COG0592	DNA-directed DNA polymerase activity
GE022_RS00025	COG0012	GTP binding
GE022_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GE022_RS00040	COG2244	polysaccharide biosynthetic process
GE022_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GE022_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GE022_RS00075	COG0531	amino acid
GE022_RS00100	COG4372	Transposase
GE022_RS00275	COG1792	Involved in formation and maintenance of cell shape
GE022_RS00285	COG3942	CHAP domain
GE022_RS00300	COG0416	fatty acid biosynthetic process
GE022_RS00305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GE022_RS00310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GE022_RS00315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GE022_RS00325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GE022_RS00330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GE022_RS00345	COG3942	CHAP domain
GE022_RS00350	COG0151	Belongs to the GarS family
GE022_RS00355	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GE022_RS00365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GE022_RS00380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GE022_RS00395	COG1454	alcohol dehydrogenase
GE022_RS00395	COG1012	belongs to the aldehyde dehydrogenase family
GE022_RS00400	COG1064	alcohol dehydrogenase
GE022_RS00420	COG0051	transcription antitermination factor activity, RNA binding
GE022_RS00520	COG0200	Binds to the 23S rRNA
GE022_RS00525	COG0201	protein transport
GE022_RS00545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GE022_RS00695	COG1252	NADH dehydrogenase
GE022_RS00700	COG1271	oxidase subunit
GE022_RS00705	COG1294	oxidase, subunit
GE022_RS00710	COG4988	ABC transporter
GE022_RS00715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GE022_RS00720	COG0142	geranyltranstransferase activity
GE022_RS00735	COG1121	(ABC) transporter
GE022_RS00740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GE022_RS00750	COG0582	viral genome integration into host DNA
GE022_RS00770	COG3617	BRO family, N-terminal domain
GE022_RS00825	COG4499	WXG100 protein secretion system (Wss), protein YukC
GE022_RS00825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE022_RS00845	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GE022_RS00850	COG1459	type II secretion system
GE022_RS00855	COG4537	Required for transformation and DNA binding
GE022_RS00880	COG2890	protein-(glutamine-N5) methyltransferase activity
GE022_RS00905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GE022_RS00910	COG1363	Peptidase, m42
GE022_RS00920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GE022_RS00925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GE022_RS00935	COG1428	Deoxynucleoside kinase
GE022_RS00940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GE022_RS00985	COG2031	fatty acid transporter
GE022_RS00995	COG0183	Belongs to the thiolase family
GE022_RS01000	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GE022_RS01015	COG0251	oxidation-reduction process
GE022_RS01030	COG1269	ATP hydrolysis coupled proton transport
GE022_RS01035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GE022_RS01045	COG1527	subunit (C
GE022_RS01050	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
GE022_RS01080	COG1744	ABC transporter substrate-binding protein PnrA-like
GE022_RS01085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GE022_RS01090	COG1349	DNA-binding transcription factor activity
GE022_RS01095	COG2390	Transcriptional regulator
GE022_RS01100	COG1447	Phosphotransferase system cellobiose-specific component IIA
GE022_RS01105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE022_RS01110	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE022_RS01115	COG1882	Formate acetyltransferase
GE022_RS01130	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GE022_RS01155	COG3655	Transcriptional regulator
GE022_RS01165	COG2205	protein histidine kinase activity
GE022_RS01170	COG0745	RESPONSE REGULATOR receiver
GE022_RS01180	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GE022_RS01185	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GE022_RS01190	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GE022_RS01225	COG2207	Transcriptional regulator
GE022_RS01235	COG1175	transmembrane transport
GE022_RS01240	COG0395	ABC-type sugar transport system, permease component
GE022_RS01255	COG2017	converts alpha-aldose to the beta-anomer
GE022_RS01260	COG1609	Transcriptional regulator
GE022_RS01265	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GE022_RS01270	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GE022_RS01275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GE022_RS01300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GE022_RS01305	COG0512	Glutamine amidotransferase of anthranilate synthase
GE022_RS01310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GE022_RS01330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GE022_RS01335	COG1609	Transcriptional regulator
GE022_RS01340	COG1263	PTS System
GE022_RS01340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE022_RS01340	COG2190	(PTS) system
GE022_RS01350	COG1363	Peptidase, m42
GE022_RS01385	COG3842	ATPase activity
GE022_RS01395	COG1523	belongs to the glycosyl hydrolase 13 family
GE022_RS01410	COG1862	Preprotein translocase
GE022_RS01420	COG4589	Belongs to the CDS family
GE022_RS01445	COG1846	Transcriptional regulator
GE022_RS01485	COG3037	sugar-specific permease SgaT UlaA
GE022_RS01490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GE022_RS01505	COG1045	serine acetyltransferase
GE022_RS01520	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GE022_RS01535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GE022_RS01555	COG1476	TRANSCRIPTIONal
GE022_RS01560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GE022_RS01665	COG4372	Transposase
GE022_RS01710	COG0351	phosphomethylpyrimidine kinase
GE022_RS01715	COG4720	Psort location CytoplasmicMembrane, score
GE022_RS01725	COG0668	transmembrane transport
GE022_RS01730	COG0544	peptidyl-prolyl cis-trans isomerase activity
GE022_RS01735	COG3343	RNA polymerase activity
GE022_RS01750	COG3279	Response regulator of the LytR AlgR family
GE022_RS01760	COG1346	cytolysis
GE022_RS01795	COG1461	Dihydroxyacetone kinase
GE022_RS01815	COG0765	amino acid transport
GE022_RS01830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GE022_RS01840	COG0719	Fe-S assembly protein
GE022_RS01845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GE022_RS01865	COG1686	Belongs to the peptidase S11 family
GE022_RS01870	COG1686	Belongs to the peptidase S11 family
GE022_RS01875	COG4166	transmembrane transport
GE022_RS01880	COG0601	transmembrane transport
GE022_RS01885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE022_RS01890	COG0444	Belongs to the ABC transporter superfamily
GE022_RS01990	COG0383	alpha-mannosidase activity
GE022_RS02005	COG3525	Glycosyl hydrolase, family 20, catalytic domain
GE022_RS02010	COG2723	6-phospho-beta-galactosidase activity
GE022_RS02030	COG1175	transmembrane transport
GE022_RS02035	COG0395	ABC-type sugar transport system, permease component
GE022_RS02050	COG2972	Histidine kinase
GE022_RS02055	COG4753	response regulator
GE022_RS02055	COG2207	Transcriptional regulator
GE022_RS02060	COG3250	beta-galactosidase activity
GE022_RS02075	COG1605	Chorismate mutase
GE022_RS02075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GE022_RS02110	COG0534	Mate efflux family protein
GE022_RS02130	COG0346	lactoylglutathione lyase activity
GE022_RS02175	COG1518	maintenance of DNA repeat elements
GE022_RS02180	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GE022_RS02185	COG0673	inositol 2-dehydrogenase activity
GE022_RS02195	COG0785	Cytochrome C biogenesis protein
GE022_RS02200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GE022_RS02215	COG2972	Histidine kinase
GE022_RS02240	COG2235	arginine
GE022_RS02245	COG0454	-acetyltransferase
GE022_RS02255	COG1288	antiporter activity
GE022_RS02260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GE022_RS02265	COG0549	Belongs to the carbamate kinase family
GE022_RS02275	COG0742	ribosomal rna small subunit methyltransferase
GE022_RS02285	COG3480	Lon protease (S16) C-terminal proteolytic domain
GE022_RS02290	COG1609	Transcriptional regulator
GE022_RS02295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GE022_RS02300	COG1869	D-ribose catabolic process
GE022_RS02310	COG1172	Belongs to the binding-protein-dependent transport system permease family
GE022_RS02315	COG1879	ABC-type sugar transport system periplasmic component
GE022_RS02320	COG4470	Protein conserved in bacteria
GE022_RS02325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GE022_RS02335	COG1132	(ABC) transporter
GE022_RS02340	COG1132	(ABC) transporter
GE022_RS02350	COG0783	Belongs to the Dps family
GE022_RS02360	COG1940	carbohydrate kinase activity
GE022_RS02410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GE022_RS02430	COG3599	regulation of cell shape
GE022_RS02450	COG0542	response to heat
GE022_RS02455	COG4703	Protein of unknown function (DUF1797)
GE022_RS02460	COG0765	amino acid transport
GE022_RS02470	COG1918	ferrous iron import across plasma membrane
GE022_RS02485	COG1378	Sugar-specific transcriptional regulator TrmB
GE022_RS02500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GE022_RS02510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GE022_RS02530	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GE022_RS02535	COG1438	arginine binding
GE022_RS02540	COG0497	DNA recombination
GE022_RS02555	COG2755	lipolytic protein G-D-S-L family
GE022_RS02575	COG2217	Heavy metal translocating P-type atpase
GE022_RS02595	COG1827	regulation of RNA biosynthetic process
GE022_RS02605	COG2116	formate transmembrane transporter activity
GE022_RS02610	COG0768	penicillin binding
GE022_RS02625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GE022_RS02645	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GE022_RS02655	COG0513	Belongs to the DEAD box helicase family
GE022_RS02670	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GE022_RS02675	COG0204	Acyl-transferase
GE022_RS02680	COG1555	photosystem II stabilization
GE022_RS02680	COG1596	polysaccharide export
GE022_RS02685	COG0658	competence protein
GE022_RS02685	COG2333	competence protein COMEC
GE022_RS02720	COG1187	pseudouridine synthase activity
GE022_RS02750	COG0546	phosphoglycolate phosphatase activity
GE022_RS02760	COG2223	nitrite transmembrane transporter activity
GE022_RS02765	COG4122	O-methyltransferase activity
GE022_RS02780	COG1476	TRANSCRIPTIONal
GE022_RS02800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GE022_RS02805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GE022_RS02810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GE022_RS02825	COG1012	belongs to the aldehyde dehydrogenase family
GE022_RS02830	COG0726	polysaccharide deacetylase
GE022_RS02835	COG0513	Belongs to the DEAD box helicase family
GE022_RS02855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GE022_RS02865	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GE022_RS02865	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GE022_RS02890	COG2186	Transcriptional regulator
GE022_RS02900	COG4109	DRTGG domain
GE022_RS02925	COG1316	TRANSCRIPTIONal
GE022_RS02945	COG1484	DNA-dependent DNA replication
GE022_RS03085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GE022_RS03085	COG0551	DNA topoisomerase type I activity
GE022_RS03115	COG0745	RESPONSE REGULATOR receiver
GE022_RS03120	COG2205	protein histidine kinase activity
GE022_RS03175	COG1129	ABC transporter
GE022_RS03185	COG1132	(ABC) transporter
GE022_RS03190	COG0534	Mate efflux family protein
GE022_RS03230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GE022_RS03295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GE022_RS03295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GE022_RS03345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GE022_RS03395	COG4695	Portal protein
GE022_RS03400	COG0740	serine-type endopeptidase activity
GE022_RS03515	COG3620	sequence-specific DNA binding
GE022_RS03570	COG1388	LysM domain
GE022_RS03570	COG3942	CHAP domain
GE022_RS03645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GE022_RS03680	COG1464	Belongs to the NlpA lipoprotein family
GE022_RS03700	COG2814	Major facilitator Superfamily
GE022_RS03720	COG2309	aminopeptidase activity
GE022_RS03745	COG2723	6-phospho-beta-galactosidase activity
GE022_RS03755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GE022_RS03755	COG3711	transcriptional antiterminator
GE022_RS03765	COG1447	Phosphotransferase system cellobiose-specific component IIA
GE022_RS03775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE022_RS03780	COG1126	abc transporter atp-binding protein
GE022_RS03785	COG0765	amino acid transport
GE022_RS03790	COG0556	nucleotide-excision repair
GE022_RS03805	COG1696	Membrane protein involved in D-alanine export
GE022_RS03815	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GE022_RS03830	COG3833	ABC-type maltose transport systems, permease component
GE022_RS03835	COG1175	transmembrane transport
GE022_RS03840	COG2182	Extracellular solute-binding protein
GE022_RS03845	COG1609	Transcriptional regulator
GE022_RS03850	COG1640	4-alpha-glucanotransferase
GE022_RS03855	COG0058	SHG alpha-glucan phosphorylase activity
GE022_RS03900	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GE022_RS03905	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GE022_RS03915	COG0300	oxidoreductase activity
GE022_RS03920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GE022_RS03920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GE022_RS03935	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GE022_RS03940	COG2384	SAM-dependent methyltransferase
GE022_RS03955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GE022_RS03960	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GE022_RS03970	COG1088	dTDP-glucose 4,6-dehydratase activity
GE022_RS03980	COG2706	6-phosphogluconolactonase activity
GE022_RS03985	COG1051	belongs to the nudix hydrolase family
GE022_RS03990	COG0628	permease
GE022_RS03995	COG0457	Tetratricopeptide repeat
GE022_RS04000	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GE022_RS04020	COG1122	ATPase activity
GE022_RS04035	COG0488	(ABC) transporter
GE022_RS04040	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GE022_RS04045	COG0022	dehydrogenase e1 component
GE022_RS04045	COG0508	dehydrogenase complex catalyzes the overall conversion of
GE022_RS04050	COG0508	dehydrogenase complex catalyzes the overall conversion of
GE022_RS04090	COG0095	Lipoate-protein ligase
GE022_RS04095	COG3442	glutamine amidotransferase
GE022_RS04100	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GE022_RS04105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GE022_RS04125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GE022_RS04135	COG0647	UMP catabolic process
GE022_RS04175	COG3715	PTS system
GE022_RS04180	COG3716	PTS system mannose fructose sorbose family IID component
GE022_RS04185	COG2972	Histidine kinase
GE022_RS04190	COG4753	response regulator
GE022_RS04190	COG2207	Transcriptional regulator
GE022_RS04195	COG1840	ABC-type Fe3 transport system, periplasmic component
GE022_RS04210	COG1011	Hydrolase
GE022_RS04215	COG1012	belongs to the aldehyde dehydrogenase family
GE022_RS04225	COG0028	Belongs to the TPP enzyme family
GE022_RS04235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GE022_RS04260	COG0398	Pfam SNARE associated Golgi protein
GE022_RS04270	COG1131	(ABC) transporter
GE022_RS04275	COG1725	Transcriptional regulator
GE022_RS04290	COG0469	pyruvate kinase activity
GE022_RS04305	COG2824	Alkylphosphonate utilization operon protein PhnA
GE022_RS04310	COG0765	amino acid transport
GE022_RS04315	COG1126	abc transporter atp-binding protein
GE022_RS04320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE022_RS04330	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GE022_RS04335	COG1115	amino acid carrier protein
GE022_RS04345	COG2261	transglycosylase associated protein
GE022_RS04385	COG1136	(ABC) transporter
GE022_RS04385	COG4591	ABC-type transport system involved in lipoprotein release permease component
GE022_RS04415	COG0196	riboflavin kinase activity
GE022_RS04430	COG0483	inositol monophosphate 1-phosphatase activity
GE022_RS04435	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GE022_RS04435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GE022_RS04445	COG0573	inorganic phosphate transmembrane transporter activity
GE022_RS04450	COG0581	inorganic phosphate transmembrane transporter activity
GE022_RS04465	COG0704	Plays a role in the regulation of phosphate uptake
GE022_RS04475	COG0745	RESPONSE REGULATOR receiver
GE022_RS04480	COG5002	protein histidine kinase activity
GE022_RS04495	COG2813	Specifically methylates the guanine in position
GE022_RS04500	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GE022_RS04515	COG1744	ABC transporter substrate-binding protein PnrA-like
GE022_RS04540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GE022_RS04545	COG4684	Psort location CytoplasmicMembrane, score
GE022_RS04550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GE022_RS04555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GE022_RS04560	COG0095	Lipoate-protein ligase
GE022_RS04570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GE022_RS04600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GE022_RS04605	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GE022_RS04605	COG1328	CTP reductase activity
GE022_RS04610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GE022_RS04625	COG0488	(ABC) transporter
GE022_RS04645	COG1272	protein, Hemolysin III
GE022_RS04665	COG0758	DNA mediated transformation
GE022_RS04670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GE022_RS04705	COG1136	(ABC) transporter
GE022_RS04710	COG0577	efflux transmembrane transporter activity
GE022_RS04715	COG0745	RESPONSE REGULATOR receiver
GE022_RS04720	COG5002	protein histidine kinase activity
GE022_RS04730	COG1252	NADH dehydrogenase
GE022_RS04735	COG0142	geranyltranstransferase activity
GE022_RS04740	COG4939	FMN-binding domain protein
GE022_RS04770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GE022_RS04780	COG2188	Transcriptional regulator
GE022_RS04805	COG0803	Belongs to the bacterial solute-binding protein 9 family
GE022_RS04820	COG0803	Belongs to the bacterial solute-binding protein 9 family
GE022_RS04825	COG0346	lactoylglutathione lyase activity
GE022_RS04830	COG3764	Sortase (surface protein transpeptidase)
GE022_RS04880	COG2890	protein-(glutamine-N5) methyltransferase activity
GE022_RS04905	COG2233	PERMEase
GE022_RS04920	COG1174	glycine betaine transport
GE022_RS04935	COG4221	oxidoreductase activity
GE022_RS04940	COG0280	phosphate acetyltransferase
GE022_RS04945	COG0564	pseudouridine synthase activity
GE022_RS04955	COG2357	RelA SpoT domain protein
GE022_RS04970	COG1104	cysteine desulfurase activity
GE022_RS04990	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GE022_RS05000	COG0628	permease
GE022_RS05030	COG1177	transmembrane transport
GE022_RS05035	COG1176	ABC-type spermidine putrescine transport system, permease component I
GE022_RS05050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GE022_RS05065	COG0302	gtp cyclohydrolase
GE022_RS05070	COG0285	dihydrofolate synthase activity
GE022_RS05095	COG0726	polysaccharide deacetylase
GE022_RS05105	COG0539	negative regulation of cytoplasmic translation
GE022_RS05125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GE022_RS05140	COG0187	DNA topoisomerase II activity
GE022_RS05160	COG0765	amino acid transport
GE022_RS05165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE022_RS05250	COG4974	Belongs to the 'phage' integrase family
GE022_RS05260	COG1396	sequence-specific DNA binding
GE022_RS05280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE022_RS05280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GE022_RS05290	COG3711	transcriptional antiterminator
GE022_RS05295	COG3684	Belongs to the aldolase LacD family
GE022_RS05300	COG1105	Belongs to the carbohydrate kinase PfkB family
GE022_RS05305	COG0698	ribose 5-phosphate isomerase
GE022_RS05315	COG1349	DNA-binding transcription factor activity
GE022_RS05320	COG3843	relaxase mobilization nuclease domain protein
GE022_RS05345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GE022_RS05530	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GE022_RS05540	COG3425	synthase
GE022_RS05575	COG1132	(ABC) transporter
GE022_RS05580	COG1132	(ABC) transporter
GE022_RS05585	COG0737	Belongs to the 5'-nucleotidase family
GE022_RS05590	COG0242	peptide deformylase activity
GE022_RS05595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GE022_RS05600	COG0488	(ABC) transporter
GE022_RS05625	COG1705	Flagellar rod assembly protein muramidase FlgJ
GE022_RS05625	COG1388	LysM domain
GE022_RS05630	COG1388	LysM domain
GE022_RS05630	COG1705	Flagellar rod assembly protein muramidase FlgJ
GE022_RS05635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GE022_RS05635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GE022_RS05635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GE022_RS05640	COG1105	Belongs to the carbohydrate kinase PfkB family
GE022_RS05645	COG1349	DNA-binding transcription factor activity
GE022_RS05680	COG1837	Belongs to the UPF0109 family
GE022_RS05690	COG0584	glycerophosphoryl diester phosphodiesterase
GE022_RS05700	COG0577	efflux transmembrane transporter activity
GE022_RS05705	COG1136	(ABC) transporter
GE022_RS05745	COG0564	pseudouridine synthase activity
GE022_RS05755	COG0583	DNA-binding transcription factor activity
GE022_RS05760	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GE022_RS05785	COG1104	cysteine desulfurase activity
GE022_RS05795	COG0285	dihydrofolate synthase activity
GE022_RS05800	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GE022_RS05820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GE022_RS05825	COG1368	sulfuric ester hydrolase activity
GE022_RS05870	COG0860	N-Acetylmuramoyl-L-alanine amidase
GE022_RS05885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GE022_RS05900	COG1216	Glycosyl transferase, family 2
GE022_RS05955	COG2151	metal-sulfur cluster biosynthetic enzyme
GE022_RS05960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GE022_RS05965	COG0358	DNA primase activity
GE022_RS05970	COG1970	mechanosensitive ion channel activity
GE022_RS05980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE022_RS05985	COG0436	Aminotransferase
GE022_RS06025	COG2801	Transposase and inactivated derivatives
GE022_RS06105	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GE022_RS06110	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GE022_RS06115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GE022_RS06120	COG1523	belongs to the glycosyl hydrolase 13 family
GE022_RS06125	COG1597	lipid kinase activity
GE022_RS06135	COG4708	membrane
GE022_RS06155	COG1131	(ABC) transporter
GE022_RS06240	COG0038	chloride channel
GE022_RS06250	COG0716	FMN binding
GE022_RS06265	COG2153	protein acetylation
GE022_RS06270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GE022_RS06285	COG3716	PTS system mannose fructose sorbose family IID component
GE022_RS06290	COG3715	PTS system
GE022_RS06315	COG2222	sugar isomerase
GE022_RS06320	COG2188	Transcriptional regulator
GE022_RS06360	COG0017	Asparaginyl-tRNA synthetase
GE022_RS06365	COG0436	Aminotransferase
GE022_RS06370	COG1199	ATP-dependent helicase activity
GE022_RS06370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GE022_RS06380	COG2177	Part of the ABC transporter FtsEX involved in
GE022_RS06385	COG2884	Cell division ATP-binding protein ftsE
GE022_RS06395	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GE022_RS06400	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GE022_RS06405	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GE022_RS06430	COG0800	Aldolase
GE022_RS06445	COG1028	Short-chain dehydrogenase reductase Sdr
GE022_RS06450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE022_RS06450	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GE022_RS06460	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE022_RS06465	COG3715	PTS system
GE022_RS06470	COG3716	PTS system mannose fructose sorbose family IID component
GE022_RS06480	COG1609	Transcriptional regulator
GE022_RS06540	COG0741	lytic transglycosylase activity
GE022_RS06540	COG0791	NLP P60 protein
GE022_RS06570	COG2946	Replication initiation factor
GE022_RS06580	COG1674	ftsk spoiiie
GE022_RS06595	COG1078	dGTPase activity
GE022_RS06605	COG2348	transferase activity, transferring amino-acyl groups
GE022_RS06650	COG0772	Belongs to the SEDS family
GE022_RS06660	COG1164	Oligoendopeptidase f
GE022_RS06665	COG0386	Belongs to the glutathione peroxidase family
GE022_RS06690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GE022_RS06695	COG2801	Transposase and inactivated derivatives
GE022_RS06705	COG2801	Transposase and inactivated derivatives
GE022_RS06720	COG2801	Transposase and inactivated derivatives
GE022_RS06730	COG4443	Transcriptional Coactivator p15 (PC4)
GE022_RS06785	COG2183	response to ionizing radiation
GE022_RS06805	COG0701	Predicted permease
GE022_RS06810	COG3689	TIGRFAM TIGR03943 family protein
GE022_RS06820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE022_RS06820	COG1263	PTS System
GE022_RS06820	COG2190	(PTS) system
GE022_RS06825	COG3711	transcriptional antiterminator
GE022_RS06830	COG0477	Major facilitator Superfamily
GE022_RS06835	COG0552	protein localization to endoplasmic reticulum
GE022_RS06840	COG0561	phosphatase activity
GE022_RS06845	COG0561	phosphatase activity
GE022_RS06855	COG1196	nuclear chromosome segregation
GE022_RS06865	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GE022_RS06870	COG5002	protein histidine kinase activity
GE022_RS06875	COG0745	RESPONSE REGULATOR receiver
GE022_RS06890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GE022_RS06895	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GE022_RS06900	COG1461	Dihydroxyacetone kinase
GE022_RS06905	COG2376	Dihydroxyacetone kinase
GE022_RS06915	COG2376	Dihydroxyacetone kinase
GE022_RS06940	COG4555	ABC transporter
GE022_RS06950	COG0438	transferase activity, transferring glycosyl groups
GE022_RS06965	COG1609	Transcriptional regulator
GE022_RS06970	COG0006	proline dipeptidase activity
GE022_RS06975	COG0778	Nitroreductase
GE022_RS06980	COG0346	lactoylglutathione lyase activity
GE022_RS06985	COG0463	Glycosyl transferase, family 2
GE022_RS06995	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GE022_RS07000	COG0557	exoribonuclease II activity
GE022_RS07015	COG2814	Major facilitator Superfamily
GE022_RS07020	COG0433	COG0433 Predicted ATPase
GE022_RS07030	COG1131	(ABC) transporter
GE022_RS07045	COG1396	sequence-specific DNA binding
GE022_RS07085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GE022_RS07095	COG1573	uracil-dna glycosylase
GE022_RS07100	COG1702	phosphate starvation-inducible protein PhoH
GE022_RS07190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GE022_RS07215	COG0673	inositol 2-dehydrogenase activity
GE022_RS07230	COG1028	Short-chain dehydrogenase reductase Sdr
GE022_RS07255	COG1114	Component of the transport system for branched-chain amino acids
GE022_RS07295	COG1304	FMN binding
GE022_RS07310	COG0708	Exodeoxyribonuclease III
GE022_RS07315	COG0561	phosphatase activity
GE022_RS07320	COG1609	Transcriptional regulator
GE022_RS07335	COG1393	Belongs to the ArsC family
GE022_RS07375	COG1774	PSP1 C-terminal conserved region
GE022_RS07380	COG0470	DNA polymerase III
GE022_RS07415	COG2244	polysaccharide biosynthetic process
GE022_RS07425	COG1120	ATPase activity
GE022_RS07430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GE022_RS07435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE022_RS07440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GE022_RS07455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GE022_RS07460	COG1253	flavin adenine dinucleotide binding
GE022_RS07465	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GE022_RS07470	COG1242	4 iron, 4 sulfur cluster binding
GE022_RS07475	COG0671	phosphoesterase, PA-phosphatase related
GE022_RS07480	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GE022_RS07515	COG1187	pseudouridine synthase activity
GE022_RS07570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GE022_RS07580	COG1254	Belongs to the acylphosphatase family
GE022_RS07595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GE022_RS07615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GE022_RS07625	COG1484	DNA-dependent DNA replication
GE022_RS07635	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GE022_RS07640	COG5002	protein histidine kinase activity
GE022_RS07645	COG0745	RESPONSE REGULATOR receiver
GE022_RS07655	COG0501	Belongs to the peptidase M48B family
GE022_RS07660	COG1704	LemA family
GE022_RS07670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GE022_RS07675	COG0569	domain protein
GE022_RS07685	COG1114	Component of the transport system for branched-chain amino acids
GE022_RS07705	COG1464	Belongs to the NlpA lipoprotein family
GE022_RS07710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GE022_RS07720	COG0789	Transcriptional regulator
GE022_RS07725	COG1323	Belongs to the UPF0348 family
GE022_RS07730	COG2226	methyltransferase
GE022_RS07735	COG0799	negative regulation of ribosome biogenesis
GE022_RS07745	COG1713	HD superfamily hydrolase involved in NAD metabolism
GE022_RS07755	COG1534	Rna-binding protein
GE022_RS07760	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GE022_RS07765	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GE022_RS07825	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GE022_RS07830	COG1739	Uncharacterized protein family UPF0029
GE022_RS07840	COG1098	S1 RNA binding domain
GE022_RS07850	COG2197	response regulator
GE022_RS07855	COG4585	Histidine kinase
GE022_RS07865	COG2815	serine threonine protein kinase
GE022_RS07865	COG0515	serine threonine protein kinase
GE022_RS07875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GE022_RS07875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GE022_RS07885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GE022_RS07905	COG0183	Belongs to the thiolase family
GE022_RS07925	COG0116	Belongs to the methyltransferase superfamily
GE022_RS07950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE022_RS07955	COG3579	cysteine-type endopeptidase activity
GE022_RS07965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GE022_RS07970	COG1113	amino acid transport
GE022_RS07985	COG1126	abc transporter atp-binding protein
GE022_RS07990	COG0765	amino acid transport
GE022_RS08000	COG0513	Belongs to the DEAD box helicase family
GE022_RS08010	COG0768	penicillin binding
GE022_RS08045	COG1131	(ABC) transporter
GE022_RS08070	COG0446	pyridine nucleotide-disulphide oxidoreductase
GE022_RS08075	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GE022_RS08110	COG1755	Isoprenylcysteine carboxyl methyltransferase
GE022_RS08115	COG0656	L-ascorbic acid biosynthetic process
GE022_RS08145	COG0561	phosphatase activity
GE022_RS08150	COG2860	membrane
GE022_RS08165	COG1105	Belongs to the carbohydrate kinase PfkB family
GE022_RS08205	COG2217	Heavy metal translocating P-type atpase
GE022_RS08245	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GE022_RS08250	COG0195	Participates in both transcription termination and antitermination
GE022_RS08275	COG4473	ABC transporter
GE022_RS08280	COG1131	(ABC) transporter
GE022_RS08285	COG0537	adenosine 5'-monophosphoramidase activity
GE022_RS08295	COG1316	TRANSCRIPTIONal
GE022_RS08300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GE022_RS08305	COG0802	atpase or kinase
GE022_RS08310	COG2252	PERMEase
GE022_RS08315	COG0561	phosphatase activity
GE022_RS08325	COG3715	PTS system
GE022_RS08330	COG3716	PTS system mannose fructose sorbose family IID component
GE022_RS08360	COG0439	Biotin carboxylase
GE022_RS08375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GE022_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
GE022_RS08385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GE022_RS08410	COG1024	Enoyl-CoA hydratase
GE022_RS08415	COG0484	heat shock protein binding
GE022_RS08430	COG1420	regulation of RNA biosynthetic process
GE022_RS08445	COG0588	phosphoglycerate mutase activity
GE022_RS08450	COG2261	transglycosylase associated protein
GE022_RS08455	COG0697	spore germination
GE022_RS08475	COG0574	Belongs to the PEP-utilizing enzyme family
GE022_RS08475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GE022_RS08480	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GE022_RS08485	COG0517	IMP dehydrogenase activity
GE022_RS08490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GE022_RS08495	COG1335	isochorismatase
GE022_RS08505	COG0436	Aminotransferase
GE022_RS08515	COG0561	phosphatase activity
GE022_RS08520	COG0252	asparaginase activity
GE022_RS08525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GE022_RS08530	COG1129	ABC transporter
GE022_RS08545	COG1132	(ABC) transporter
GE022_RS08550	COG4988	ABC transporter
GE022_RS08555	COG1120	ATPase activity
GE022_RS08580	COG3942	CHAP domain
GE022_RS08580	COG1388	LysM domain
GE022_RS08600	COG1482	cell wall glycoprotein biosynthetic process
GE022_RS08605	COG1940	carbohydrate kinase activity
GE022_RS08615	COG1263	PTS System
GE022_RS08615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE022_RS08615	COG2190	(PTS) system
GE022_RS08620	COG1621	beta-fructofuranosidase activity
GE022_RS08625	COG1609	Transcriptional regulator
GE022_RS08645	COG2131	deaminase
GE022_RS08650	COG0006	proline dipeptidase activity
GE022_RS08695	COG1194	a g-specific adenine glycosylase
GE022_RS08700	COG3118	belongs to the thioredoxin family
GE022_RS08705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GE022_RS08730	COG0681	Belongs to the peptidase S26 family
GE022_RS08735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GE022_RS08750	COG1882	Formate acetyltransferase
GE022_RS08760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GE022_RS08775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GE022_RS08820	COG0789	Transcriptional regulator
GE022_RS08835	COG2081	HI0933 family
GE022_RS08855	COG1214	PFAM Peptidase M22, glycoprotease
GE022_RS08870	COG4608	Belongs to the ABC transporter superfamily
GE022_RS08875	COG0444	Belongs to the ABC transporter superfamily
GE022_RS08880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GE022_RS08885	COG0601	transmembrane transport
GE022_RS08890	COG4166	transmembrane transport
GE022_RS08895	COG0174	glutamine synthetase
GE022_RS08900	COG0789	Transcriptional regulator
GE022_RS08920	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GE022_RS08950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GE022_RS08965	COG1564	THIamine pyrophosphokinase
GE022_RS08980	COG2814	Major facilitator Superfamily
GE022_RS08990	COG1288	antiporter activity
GE022_RS08995	COG0549	Belongs to the carbamate kinase family
GE022_RS09000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GE022_RS09010	COG0784	Response regulator, receiver
GE022_RS09030	COG0084	hydrolase, TatD family'
GE022_RS09040	COG2814	Major facilitator Superfamily
GE022_RS09045	COG1335	isochorismatase
GE022_RS09055	COG2190	(PTS) system
GE022_RS09055	COG1263	PTS System
GE022_RS09055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GE022_RS09115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GE022_RS09135	COG0673	inositol 2-dehydrogenase activity
GE022_RS09140	COG4409	exo-alpha-(2->6)-sialidase activity
GE022_RS09150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GE022_RS09155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GE022_RS09160	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
GE022_RS09190	COG0629	single-stranded DNA binding
GE022_RS09220	COG0542	response to heat
GE022_RS09415	COG0756	dUTP diphosphatase activity
GE022_RS09425	COG1132	(ABC) transporter
GE022_RS09430	COG1132	(ABC) transporter
GE022_RS09440	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GE022_RS09445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GE022_RS09450	COG0457	Tetratricopeptide repeat
GE022_RS09450	COG0705	Rhomboid family
GE022_RS09455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GE022_RS09500	COG1234	tRNA 3'-trailer cleavage
GE022_RS09505	COG1268	BioY protein
GE022_RS09515	COG0343	queuine tRNA-ribosyltransferase activity
GE022_RS09535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GE022_RS09535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GE022_RS09545	COG3448	diguanylate cyclase activity
GE022_RS09545	COG4175	Glycine betaine
GE022_RS09550	COG1597	lipid kinase activity
GE022_RS09570	COG1070	Carbohydrate kinase
GE022_RS09580	COG3775	system Galactitol-specific IIC component
GE022_RS09585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GE022_RS09595	COG1609	Transcriptional regulator
GE022_RS09605	COG3623	hexulose-6-phosphate isomerase
GE022_RS09630	COG0495	leucyl-tRNA aminoacylation
GE022_RS09655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GE022_RS09670	COG0564	pseudouridine synthase activity
GE022_RS09685	COG0494	nUDIX hydrolase
GE022_RS09710	COG0542	response to heat
GE022_RS09715	COG4463	regulation of RNA biosynthetic process
GE022_RS09770	COG0346	lactoylglutathione lyase activity
GE022_RS09775	COG0346	lactoylglutathione lyase activity
GE022_RS09780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GE022_RS09795	COG0450	alkyl hydroperoxide reductase
GE022_RS09810	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GE022_RS09820	COG3404	Formiminotransferase-cyclodeaminase
GE022_RS09835	COG0531	amino acid
GE022_RS09870	COG3590	peptidase
GE022_RS09885	COG0602	queuosine metabolic process
GE022_RS09905	COG1328	CTP reductase activity
GE022_RS09925	COG4472	Bacterial protein of unknown function (DUF965)
GE022_RS09930	COG1393	Belongs to the ArsC family
GE022_RS09950	COG0519	Catalyzes the synthesis of GMP from XMP
GE022_RS10035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GE022_RS10040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GE022_RS10045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GE022_RS10150	COG1511	domain protein
GE022_RS10300	COG0305	Participates in initiation and elongation during chromosome replication
GE022_RS10335	COG1760	l-serine dehydratase
GE022_RS10340	COG1760	l-serine dehydratase
GE022_RS10350	COG0741	lytic transglycosylase activity
GE022_RS10370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GE022_RS10380	COG0612	Peptidase, M16
GE022_RS10385	COG0612	Peptidase, M16
GE022_RS10400	COG4485	Bacterial membrane protein, YfhO
GE022_RS10405	COG0488	(ABC) transporter
GE022_RS10410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GE022_RS10420	COG0516	GMP reductase activity
GE022_RS10420	COG0517	IMP dehydrogenase activity
GE022_RS10465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain