locus-tag	class	description
I6H73_RS00010	COG1121	(ABC) transporter
I6H73_RS00015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H73_RS00025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H73_RS00025	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6H73_RS00045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H73_RS00050	COG1459	type II secretion system
I6H73_RS00055	COG4537	Required for transformation and DNA binding
I6H73_RS00060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H73_RS00070	COG1396	sequence-specific DNA binding
I6H73_RS00075	COG1396	sequence-specific DNA binding
I6H73_RS00310	COG4824	toxin secretion phage lysis holin
I6H73_RS00365	COG1266	CAAX protease self-immunity
I6H73_RS00375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H73_RS00380	COG1363	Peptidase, m42
I6H73_RS00390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H73_RS00395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H73_RS00410	COG1428	Deoxynucleoside kinase
I6H73_RS00415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H73_RS00450	COG4509	Sortase family
I6H73_RS00500	COG0251	oxidation-reduction process
I6H73_RS00525	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H73_RS00530	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H73_RS00535	COG1349	DNA-binding transcription factor activity
I6H73_RS00540	COG2390	Transcriptional regulator
I6H73_RS00545	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6H73_RS00550	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H73_RS00555	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H73_RS00560	COG1882	Formate acetyltransferase
I6H73_RS00575	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6H73_RS00600	COG3655	Transcriptional regulator
I6H73_RS00615	COG0488	(ABC) transporter
I6H73_RS00665	COG1132	(ABC) transporter
I6H73_RS00700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H73_RS00705	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H73_RS00710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H73_RS00725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H73_RS00730	COG1609	Transcriptional regulator
I6H73_RS00735	COG2190	(PTS) system
I6H73_RS00735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H73_RS00735	COG1263	PTS System
I6H73_RS00750	COG1363	Peptidase, m42
I6H73_RS00800	COG3842	ATPase activity
I6H73_RS00810	COG1523	belongs to the glycosyl hydrolase 13 family
I6H73_RS00825	COG1862	Preprotein translocase
I6H73_RS00835	COG4589	Belongs to the CDS family
I6H73_RS00860	COG1846	Transcriptional regulator
I6H73_RS00895	COG1126	abc transporter atp-binding protein
I6H73_RS00905	COG3711	transcriptional antiterminator
I6H73_RS00920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H73_RS00935	COG1045	serine acetyltransferase
I6H73_RS00950	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6H73_RS00970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H73_RS00990	COG1476	TRANSCRIPTIONal
I6H73_RS01000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H73_RS01020	COG3942	CHAP domain
I6H73_RS01020	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H73_RS01035	COG0433	COG0433 Predicted ATPase
I6H73_RS01070	COG4115	mRNA cleavage
I6H73_RS01100	COG3620	sequence-specific DNA binding
I6H73_RS01120	COG3620	sequence-specific DNA binding
I6H73_RS01170	COG3414	Phosphotransferase system galactitol-specific IIB component
I6H73_RS01190	COG0561	phosphatase activity
I6H73_RS01235	COG0527	aspartate kinase activity
I6H73_RS01245	COG0351	phosphomethylpyrimidine kinase
I6H73_RS01250	COG4720	Psort location CytoplasmicMembrane, score
I6H73_RS01260	COG0668	transmembrane transport
I6H73_RS01265	COG0366	Alpha amylase catalytic
I6H73_RS01270	COG0366	Alpha amylase catalytic
I6H73_RS01280	COG3343	RNA polymerase activity
I6H73_RS01295	COG3279	Response regulator of the LytR AlgR family
I6H73_RS01305	COG1346	cytolysis
I6H73_RS01355	COG0765	amino acid transport
I6H73_RS01375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H73_RS01385	COG0719	Fe-S assembly protein
I6H73_RS01390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H73_RS01405	COG1686	Belongs to the peptidase S11 family
I6H73_RS01415	COG1686	Belongs to the peptidase S11 family
I6H73_RS01420	COG4166	transmembrane transport
I6H73_RS01425	COG0601	transmembrane transport
I6H73_RS01430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H73_RS01435	COG0444	Belongs to the ABC transporter superfamily
I6H73_RS01490	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6H73_RS01495	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H73_RS01500	COG1534	Rna-binding protein
I6H73_RS01510	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H73_RS01520	COG0799	negative regulation of ribosome biogenesis
I6H73_RS01525	COG2226	methyltransferase
I6H73_RS01530	COG1323	Belongs to the UPF0348 family
I6H73_RS01535	COG0789	Transcriptional regulator
I6H73_RS01550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H73_RS01560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H73_RS01570	COG1464	Belongs to the NlpA lipoprotein family
I6H73_RS01590	COG1114	Component of the transport system for branched-chain amino acids
I6H73_RS01600	COG0569	domain protein
I6H73_RS01605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H73_RS01615	COG1704	LemA family
I6H73_RS01630	COG0745	RESPONSE REGULATOR receiver
I6H73_RS01635	COG5002	protein histidine kinase activity
I6H73_RS01640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H73_RS01650	COG1484	DNA-dependent DNA replication
I6H73_RS01660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H73_RS01680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H73_RS01695	COG1254	Belongs to the acylphosphatase family
I6H73_RS01700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H73_RS01735	COG4175	Glycine betaine
I6H73_RS01755	COG1187	pseudouridine synthase activity
I6H73_RS01770	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6H73_RS01775	COG0671	phosphoesterase, PA-phosphatase related
I6H73_RS01780	COG1242	4 iron, 4 sulfur cluster binding
I6H73_RS01785	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H73_RS01790	COG1253	flavin adenine dinucleotide binding
I6H73_RS01795	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H73_RS01810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H73_RS01815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H73_RS01820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H73_RS01825	COG1120	ATPase activity
I6H73_RS01835	COG2244	polysaccharide biosynthetic process
I6H73_RS01875	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H73_RS01885	COG0411	ABC transporter
I6H73_RS01895	COG0517	IMP dehydrogenase activity
I6H73_RS01905	COG0470	DNA polymerase III
I6H73_RS01910	COG1774	PSP1 C-terminal conserved region
I6H73_RS01935	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6H73_RS01950	COG1393	Belongs to the ArsC family
I6H73_RS01965	COG0708	Exodeoxyribonuclease III
I6H73_RS01975	COG1620	l-lactate permease
I6H73_RS01980	COG1304	FMN binding
I6H73_RS02020	COG1114	Component of the transport system for branched-chain amino acids
I6H73_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
I6H73_RS02050	COG0673	inositol 2-dehydrogenase activity
I6H73_RS02075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H73_RS02100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H73_RS02165	COG1702	phosphate starvation-inducible protein PhoH
I6H73_RS02170	COG1573	uracil-dna glycosylase
I6H73_RS02180	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H73_RS02250	COG1131	(ABC) transporter
I6H73_RS02260	COG0433	COG0433 Predicted ATPase
I6H73_RS02265	COG2814	Major facilitator Superfamily
I6H73_RS02280	COG0557	exoribonuclease II activity
I6H73_RS02285	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H73_RS02295	COG0463	Glycosyl transferase, family 2
I6H73_RS02305	COG0346	lactoylglutathione lyase activity
I6H73_RS02310	COG0778	Nitroreductase
I6H73_RS02315	COG0006	proline dipeptidase activity
I6H73_RS02320	COG1609	Transcriptional regulator
I6H73_RS02335	COG0438	transferase activity, transferring glycosyl groups
I6H73_RS02345	COG4555	ABC transporter
I6H73_RS02360	COG2376	Dihydroxyacetone kinase
I6H73_RS02370	COG2376	Dihydroxyacetone kinase
I6H73_RS02375	COG1461	Dihydroxyacetone kinase
I6H73_RS02380	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6H73_RS02385	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H73_RS02395	COG0183	Belongs to the thiolase family
I6H73_RS02410	COG0765	amino acid transport
I6H73_RS02415	COG0765	amino acid transport
I6H73_RS02420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H73_RS02430	COG0745	RESPONSE REGULATOR receiver
I6H73_RS02435	COG5002	protein histidine kinase activity
I6H73_RS02440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H73_RS02450	COG1196	nuclear chromosome segregation
I6H73_RS02470	COG0561	phosphatase activity
I6H73_RS02475	COG0561	phosphatase activity
I6H73_RS02480	COG0552	protein localization to endoplasmic reticulum
I6H73_RS02485	COG0477	Major facilitator Superfamily
I6H73_RS02490	COG3711	transcriptional antiterminator
I6H73_RS02495	COG2190	(PTS) system
I6H73_RS02495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H73_RS02495	COG1263	PTS System
I6H73_RS02505	COG3689	TIGRFAM TIGR03943 family protein
I6H73_RS02510	COG0701	Predicted permease
I6H73_RS02525	COG0745	RESPONSE REGULATOR receiver
I6H73_RS02530	COG5002	protein histidine kinase activity
I6H73_RS02535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H73_RS02540	COG0573	inorganic phosphate transmembrane transporter activity
I6H73_RS02550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H73_RS02555	COG0704	Plays a role in the regulation of phosphate uptake
I6H73_RS02570	COG2183	response to ionizing radiation
I6H73_RS02615	COG0826	peptidase U32
I6H73_RS02620	COG4443	Transcriptional Coactivator p15 (PC4)
I6H73_RS02635	COG0004	ammonium transporteR
I6H73_RS02640	COG0582	viral genome integration into host DNA
I6H73_RS02650	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H73_RS02650	COG3942	CHAP domain
I6H73_RS02670	COG0433	COG0433 Predicted ATPase
I6H73_RS02720	COG1674	ftsk spoiiie
I6H73_RS02740	COG3620	sequence-specific DNA binding
I6H73_RS02760	COG3620	sequence-specific DNA binding
I6H73_RS02765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H73_RS02815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H73_RS02845	COG0386	Belongs to the glutathione peroxidase family
I6H73_RS02850	COG1164	Oligoendopeptidase f
I6H73_RS02860	COG0772	Belongs to the SEDS family
I6H73_RS02865	COG1191	sigma factor activity
I6H73_RS02935	COG1078	dGTPase activity
I6H73_RS02955	COG1609	Transcriptional regulator
I6H73_RS02965	COG3716	PTS system mannose fructose sorbose family IID component
I6H73_RS02970	COG3715	PTS system
I6H73_RS02975	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H73_RS02990	COG1028	Short-chain dehydrogenase reductase Sdr
I6H73_RS03010	COG5492	domain, Protein
I6H73_RS03030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H73_RS03035	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6H73_RS03040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H73_RS03050	COG2884	Cell division ATP-binding protein ftsE
I6H73_RS03055	COG2177	Part of the ABC transporter FtsEX involved in
I6H73_RS03065	COG1199	ATP-dependent helicase activity
I6H73_RS03065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H73_RS03070	COG0436	Aminotransferase
I6H73_RS03075	COG0017	Asparaginyl-tRNA synthetase
I6H73_RS03150	COG3723	Recombinational DNA repair protein, rece pathway
I6H73_RS03230	COG1475	DNA binding
I6H73_RS03255	COG2369	cell adhesion
I6H73_RS03415	COG2188	Transcriptional regulator
I6H73_RS03420	COG2222	sugar isomerase
I6H73_RS03445	COG3715	PTS system
I6H73_RS03450	COG3716	PTS system mannose fructose sorbose family IID component
I6H73_RS03470	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H73_RS03475	COG2153	protein acetylation
I6H73_RS03480	COG0625	glutathione transferase activity
I6H73_RS03490	COG0716	FMN binding
I6H73_RS03500	COG0038	chloride channel
I6H73_RS03515	COG0772	Belongs to the SEDS family
I6H73_RS03535	COG0560	Phosphoserine phosphatase
I6H73_RS03580	COG1131	(ABC) transporter
I6H73_RS03600	COG4708	membrane
I6H73_RS03610	COG1597	lipid kinase activity
I6H73_RS03615	COG1523	belongs to the glycosyl hydrolase 13 family
I6H73_RS03620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H73_RS03625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H73_RS03630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H73_RS03720	COG0577	efflux transmembrane transporter activity
I6H73_RS03725	COG1136	(ABC) transporter
I6H73_RS03730	COG2321	neutral zinc metallopeptidase
I6H73_RS03745	COG0436	Aminotransferase
I6H73_RS03760	COG1970	mechanosensitive ion channel activity
I6H73_RS03765	COG0358	DNA primase activity
I6H73_RS03770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H73_RS03775	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H73_RS03790	COG1216	Glycosyl transferase, family 2
I6H73_RS03790	COG1442	glycosyl transferase family 8
I6H73_RS03815	COG0463	Glycosyl transferase, family 2
I6H73_RS03830	COG0438	transferase activity, transferring glycosyl groups
I6H73_RS03835	COG1368	sulfuric ester hydrolase activity
I6H73_RS03840	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H73_RS03890	COG1368	sulfuric ester hydrolase activity
I6H73_RS03895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6H73_RS03915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H73_RS03920	COG0285	dihydrofolate synthase activity
I6H73_RS03930	COG1104	cysteine desulfurase activity
I6H73_RS03960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H73_RS04150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H73_RS04265	COG0583	DNA-binding transcription factor activity
I6H73_RS04275	COG0564	pseudouridine synthase activity
I6H73_RS04310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H73_RS04315	COG1136	(ABC) transporter
I6H73_RS04320	COG0577	efflux transmembrane transporter activity
I6H73_RS04330	COG0584	glycerophosphoryl diester phosphodiesterase
I6H73_RS04340	COG1837	Belongs to the UPF0109 family
I6H73_RS04375	COG1349	DNA-binding transcription factor activity
I6H73_RS04380	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H73_RS04385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H73_RS04385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H73_RS04385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H73_RS04390	COG1388	LysM domain
I6H73_RS04390	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H73_RS04395	COG1388	LysM domain
I6H73_RS04395	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H73_RS04420	COG0488	(ABC) transporter
I6H73_RS04430	COG1132	(ABC) transporter
I6H73_RS04435	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H73_RS04440	COG0242	peptide deformylase activity
I6H73_RS04445	COG0737	Belongs to the 5'-nucleotidase family
I6H73_RS04450	COG2357	RelA SpoT domain protein
I6H73_RS04455	COG0745	RESPONSE REGULATOR receiver
I6H73_RS04510	COG3425	synthase
I6H73_RS04520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H73_RS04575	COG1686	Belongs to the peptidase S11 family
I6H73_RS04580	COG0726	polysaccharide deacetylase
I6H73_RS04595	COG0285	dihydrofolate synthase activity
I6H73_RS04600	COG0302	gtp cyclohydrolase
I6H73_RS04630	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H73_RS04635	COG1177	transmembrane transport
I6H73_RS04645	COG4565	transcriptional regulatory protein
I6H73_RS04650	COG3290	protein histidine kinase activity
I6H73_RS04655	COG3493	citrate carrier protein
I6H73_RS04665	COG0038	chloride channel
I6H73_RS04670	COG4977	sequence-specific DNA binding
I6H73_RS04670	COG1917	Cupin 2, conserved barrel domain protein
I6H73_RS04680	COG0628	permease
I6H73_RS04690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6H73_RS04710	COG1104	cysteine desulfurase activity
I6H73_RS04725	COG2357	RelA SpoT domain protein
I6H73_RS04735	COG0564	pseudouridine synthase activity
I6H73_RS04740	COG0280	phosphate acetyltransferase
I6H73_RS04745	COG4221	oxidoreductase activity
I6H73_RS04760	COG1174	glycine betaine transport
I6H73_RS04775	COG2233	PERMEase
I6H73_RS04800	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H73_RS04805	COG0009	L-threonylcarbamoyladenylate synthase
I6H73_RS04830	COG1132	(ABC) transporter
I6H73_RS04835	COG1132	(ABC) transporter
I6H73_RS04845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H73_RS04860	COG3764	Sortase (surface protein transpeptidase)
I6H73_RS04865	COG0346	lactoylglutathione lyase activity
I6H73_RS04905	COG1136	(ABC) transporter
I6H73_RS04910	COG0577	efflux transmembrane transporter activity
I6H73_RS04915	COG0745	RESPONSE REGULATOR receiver
I6H73_RS04920	COG2205	protein histidine kinase activity
I6H73_RS04925	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H73_RS04925	COG3942	CHAP domain
I6H73_RS04945	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H73_RS04965	COG1122	ATPase activity
I6H73_RS04975	COG0601	transmembrane transport
I6H73_RS05020	COG2188	Transcriptional regulator
I6H73_RS05030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H73_RS05050	COG0673	inositol 2-dehydrogenase activity
I6H73_RS05060	COG5002	protein histidine kinase activity
I6H73_RS05065	COG0662	Cupin 2, conserved barrel domain protein
I6H73_RS05095	COG4939	FMN-binding domain protein
I6H73_RS05100	COG0142	geranyltranstransferase activity
I6H73_RS05105	COG1252	NADH dehydrogenase
I6H73_RS05115	COG5002	protein histidine kinase activity
I6H73_RS05120	COG0745	RESPONSE REGULATOR receiver
I6H73_RS05125	COG0577	efflux transmembrane transporter activity
I6H73_RS05130	COG1136	(ABC) transporter
I6H73_RS05145	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6H73_RS05180	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6H73_RS05185	COG0511	ligase activity, forming carbon-carbon bonds
I6H73_RS05195	COG2851	Citrate transporter
I6H73_RS05215	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6H73_RS05220	COG0511	ligase activity, forming carbon-carbon bonds
I6H73_RS05270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H73_RS05275	COG0758	DNA mediated transformation
I6H73_RS05310	COG1396	sequence-specific DNA binding
I6H73_RS05320	COG1272	protein, Hemolysin III
I6H73_RS05340	COG0488	(ABC) transporter
I6H73_RS05360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H73_RS05365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H73_RS05365	COG1328	CTP reductase activity
I6H73_RS05370	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H73_RS05375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H73_RS05430	COG0095	Lipoate-protein ligase
I6H73_RS05440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H73_RS05445	COG4684	Psort location CytoplasmicMembrane, score
I6H73_RS05450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H73_RS05455	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H73_RS05460	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H73_RS05465	COG3845	ABC transporter
I6H73_RS05470	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H73_RS05485	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6H73_RS05490	COG2813	Specifically methylates the guanine in position
I6H73_RS05505	COG5002	protein histidine kinase activity
I6H73_RS05510	COG0745	RESPONSE REGULATOR receiver
I6H73_RS05520	COG0704	Plays a role in the regulation of phosphate uptake
I6H73_RS05535	COG0581	inorganic phosphate transmembrane transporter activity
I6H73_RS05540	COG0573	inorganic phosphate transmembrane transporter activity
I6H73_RS05550	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6H73_RS05550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H73_RS05555	COG0483	inositol monophosphate 1-phosphatase activity
I6H73_RS05570	COG0196	riboflavin kinase activity
I6H73_RS05600	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H73_RS05600	COG1136	(ABC) transporter
I6H73_RS05640	COG2261	transglycosylase associated protein
I6H73_RS05650	COG1115	amino acid carrier protein
I6H73_RS05655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H73_RS05665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H73_RS05670	COG1126	abc transporter atp-binding protein
I6H73_RS05675	COG0765	amino acid transport
I6H73_RS05680	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H73_RS05695	COG0469	pyruvate kinase activity
I6H73_RS05710	COG1725	Transcriptional regulator
I6H73_RS05715	COG1131	(ABC) transporter
I6H73_RS05725	COG0398	Pfam SNARE associated Golgi protein
I6H73_RS05750	COG0539	negative regulation of cytoplasmic translation
I6H73_RS05770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H73_RS05785	COG0187	DNA topoisomerase II activity
I6H73_RS05805	COG0765	amino acid transport
I6H73_RS05860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6H73_RS05890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H73_RS05900	COG0028	Belongs to the TPP enzyme family
I6H73_RS05925	COG1012	belongs to the aldehyde dehydrogenase family
I6H73_RS05930	COG1011	Hydrolase
I6H73_RS05945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H73_RS05965	COG2972	Histidine kinase
I6H73_RS05970	COG3716	PTS system mannose fructose sorbose family IID component
I6H73_RS05975	COG3715	PTS system
I6H73_RS06035	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6H73_RS06040	COG1518	maintenance of DNA repeat elements
I6H73_RS06055	COG0647	UMP catabolic process
I6H73_RS06065	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H73_RS06085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6H73_RS06090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H73_RS06095	COG3442	glutamine amidotransferase
I6H73_RS06100	COG0095	Lipoate-protein ligase
I6H73_RS06110	COG1695	Transcriptional regulator
I6H73_RS06120	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H73_RS06125	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H73_RS06125	COG0022	dehydrogenase e1 component
I6H73_RS06130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6H73_RS06135	COG0488	(ABC) transporter
I6H73_RS06155	COG1122	ATPase activity
I6H73_RS06185	COG3700	Belongs to the class B bacterial acid phosphatase family
I6H73_RS06205	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6H73_RS06210	COG0457	Tetratricopeptide repeat
I6H73_RS06215	COG0628	permease
I6H73_RS06220	COG1051	belongs to the nudix hydrolase family
I6H73_RS06240	COG1088	dTDP-glucose 4,6-dehydratase activity
I6H73_RS06250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6H73_RS06255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H73_RS06270	COG2384	SAM-dependent methyltransferase
I6H73_RS06275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H73_RS06290	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H73_RS06290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H73_RS06295	COG0300	oxidoreductase activity
I6H73_RS06310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H73_RS06335	COG0572	uridine kinase
I6H73_RS06340	COG1054	Belongs to the UPF0176 family
I6H73_RS06350	COG0431	NADPH-dependent FMN reductase
I6H73_RS06355	COG0058	SHG alpha-glucan phosphorylase activity
I6H73_RS06360	COG1640	4-alpha-glucanotransferase
I6H73_RS06365	COG1609	Transcriptional regulator
I6H73_RS06375	COG2182	Extracellular solute-binding protein
I6H73_RS06385	COG3833	ABC-type maltose transport systems, permease component
I6H73_RS06405	COG1175	transmembrane transport
I6H73_RS06410	COG0366	Alpha amylase catalytic
I6H73_RS06415	COG2182	Extracellular solute-binding protein
I6H73_RS06420	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6H73_RS06430	COG1696	Membrane protein involved in D-alanine export
I6H73_RS06450	COG0765	amino acid transport
I6H73_RS06455	COG1126	abc transporter atp-binding protein
I6H73_RS06465	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H73_RS06475	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6H73_RS06485	COG3711	transcriptional antiterminator
I6H73_RS06485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H73_RS06495	COG2723	6-phospho-beta-galactosidase activity
I6H73_RS06520	COG2309	aminopeptidase activity
I6H73_RS06530	COG1187	pseudouridine synthase activity
I6H73_RS06540	COG2814	Major facilitator Superfamily
I6H73_RS06550	COG0390	transport system, permease component
I6H73_RS06555	COG4619	ABC transporter
I6H73_RS06570	COG1464	Belongs to the NlpA lipoprotein family
I6H73_RS06635	COG4109	DRTGG domain
I6H73_RS06660	COG1028	Short-chain dehydrogenase reductase Sdr
I6H73_RS06675	COG0800	Aldolase
I6H73_RS06680	COG2186	Transcriptional regulator
I6H73_RS06685	COG3250	beta-galactosidase activity
I6H73_RS06695	COG2211	Major facilitator Superfamily
I6H73_RS06715	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6H73_RS06715	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6H73_RS06725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H73_RS06730	COG1956	GAF domain-containing protein
I6H73_RS06750	COG0513	Belongs to the DEAD box helicase family
I6H73_RS06755	COG0726	polysaccharide deacetylase
I6H73_RS06775	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H73_RS06780	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H73_RS06785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H73_RS06805	COG1476	TRANSCRIPTIONal
I6H73_RS06830	COG4122	O-methyltransferase activity
I6H73_RS06835	COG2223	nitrite transmembrane transporter activity
I6H73_RS06850	COG0431	NADPH-dependent FMN reductase
I6H73_RS06870	COG1187	pseudouridine synthase activity
I6H73_RS06905	COG2333	competence protein COMEC
I6H73_RS06905	COG0658	competence protein
I6H73_RS06930	COG1388	LysM domain
I6H73_RS06930	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H73_RS06995	COG0740	serine-type endopeptidase activity
I6H73_RS07000	COG4695	Portal protein
I6H73_RS07035	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6H73_RS07055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H73_RS07105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H73_RS07105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H73_RS07150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H73_RS07175	COG0640	Transcriptional regulator
I6H73_RS07220	COG1555	photosystem II stabilization
I6H73_RS07220	COG1596	polysaccharide export
I6H73_RS07225	COG0204	Acyl-transferase
I6H73_RS07230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H73_RS07245	COG0513	Belongs to the DEAD box helicase family
I6H73_RS07250	COG1464	Belongs to the NlpA lipoprotein family
I6H73_RS07260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H73_RS07280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H73_RS07295	COG0768	penicillin binding
I6H73_RS07300	COG2116	formate transmembrane transporter activity
I6H73_RS07310	COG1827	regulation of RNA biosynthetic process
I6H73_RS07330	COG2217	Heavy metal translocating P-type atpase
I6H73_RS07355	COG2755	lipolytic protein G-D-S-L family
I6H73_RS07375	COG0497	DNA recombination
I6H73_RS07380	COG1438	arginine binding
I6H73_RS07385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6H73_RS07405	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H73_RS07415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H73_RS07420	COG0415	Belongs to the DNA photolyase family
I6H73_RS07445	COG0765	amino acid transport
I6H73_RS07450	COG4703	Protein of unknown function (DUF1797)
I6H73_RS07455	COG0542	response to heat
I6H73_RS07475	COG3599	regulation of cell shape
I6H73_RS07495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H73_RS07540	COG1217	gtp-binding protein TYPA
I6H73_RS07545	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H73_RS07550	COG1940	carbohydrate kinase activity
I6H73_RS07560	COG0783	Belongs to the Dps family
I6H73_RS07575	COG1132	(ABC) transporter
I6H73_RS07580	COG1132	(ABC) transporter
I6H73_RS07590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H73_RS07595	COG4470	Protein conserved in bacteria
I6H73_RS07615	COG1869	D-ribose catabolic process
I6H73_RS07620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H73_RS07625	COG1609	Transcriptional regulator
I6H73_RS07630	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6H73_RS07640	COG0742	ribosomal rna small subunit methyltransferase
I6H73_RS07650	COG0549	Belongs to the carbamate kinase family
I6H73_RS07660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H73_RS07665	COG1288	antiporter activity
I6H73_RS07675	COG0454	-acetyltransferase
I6H73_RS07680	COG2235	arginine
I6H73_RS07685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H73_RS07705	COG2972	Histidine kinase
I6H73_RS07720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H73_RS07725	COG0785	Cytochrome C biogenesis protein
I6H73_RS07735	COG0673	inositol 2-dehydrogenase activity
I6H73_RS07760	COG0346	lactoylglutathione lyase activity
I6H73_RS07780	COG0534	Mate efflux family protein
I6H73_RS07790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6H73_RS07790	COG1605	Chorismate mutase
I6H73_RS07830	COG3250	beta-galactosidase activity
I6H73_RS07835	COG4753	response regulator
I6H73_RS07835	COG2207	Transcriptional regulator
I6H73_RS07840	COG2972	Histidine kinase
I6H73_RS07850	COG1653	transport
I6H73_RS07855	COG0395	ABC-type sugar transport system, permease component
I6H73_RS07860	COG1175	transmembrane transport
I6H73_RS07865	COG1940	carbohydrate kinase activity
I6H73_RS07880	COG2723	6-phospho-beta-galactosidase activity
I6H73_RS07885	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6H73_RS07900	COG0383	alpha-mannosidase activity
I6H73_RS07920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H73_RS07930	COG2070	2-Nitropropane dioxygenase
I6H73_RS07935	COG0183	Belongs to the thiolase family
I6H73_RS07940	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H73_RS07940	COG1024	Enoyl-CoA hydratase
I6H73_RS08040	COG1040	competence protein
I6H73_RS08045	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6H73_RS08050	COG1739	Uncharacterized protein family UPF0029
I6H73_RS08060	COG1098	S1 RNA binding domain
I6H73_RS08070	COG2197	response regulator
I6H73_RS08075	COG4585	Histidine kinase
I6H73_RS08085	COG0515	serine threonine protein kinase
I6H73_RS08085	COG2815	serine threonine protein kinase
I6H73_RS08095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H73_RS08095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H73_RS08105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H73_RS08125	COG0583	DNA-binding transcription factor activity
I6H73_RS08130	COG0183	Belongs to the thiolase family
I6H73_RS08135	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6H73_RS08165	COG0116	Belongs to the methyltransferase superfamily
I6H73_RS08190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H73_RS08195	COG3579	cysteine-type endopeptidase activity
I6H73_RS08205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H73_RS08210	COG1113	amino acid transport
I6H73_RS08215	COG0492	ferredoxin-NADP+ reductase activity
I6H73_RS08225	COG1126	abc transporter atp-binding protein
I6H73_RS08230	COG0765	amino acid transport
I6H73_RS08240	COG0513	Belongs to the DEAD box helicase family
I6H73_RS08250	COG0768	penicillin binding
I6H73_RS08280	COG1131	(ABC) transporter
I6H73_RS08305	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H73_RS08310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H73_RS08345	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6H73_RS08350	COG0656	L-ascorbic acid biosynthetic process
I6H73_RS08360	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H73_RS08380	COG0561	phosphatase activity
I6H73_RS08385	COG2860	membrane
I6H73_RS08395	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H73_RS08420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H73_RS08435	COG2217	Heavy metal translocating P-type atpase
I6H73_RS08465	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H73_RS08470	COG0195	Participates in both transcription termination and antitermination
I6H73_RS08495	COG4473	ABC transporter
I6H73_RS08500	COG1131	(ABC) transporter
I6H73_RS08505	COG0537	adenosine 5'-monophosphoramidase activity
I6H73_RS08515	COG1316	TRANSCRIPTIONal
I6H73_RS08520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H73_RS08525	COG0802	atpase or kinase
I6H73_RS08530	COG2252	PERMEase
I6H73_RS08535	COG0561	phosphatase activity
I6H73_RS08545	COG3715	PTS system
I6H73_RS08550	COG3716	PTS system mannose fructose sorbose family IID component
I6H73_RS08580	COG0439	Biotin carboxylase
I6H73_RS08595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H73_RS08600	COG1028	Short-chain dehydrogenase reductase Sdr
I6H73_RS08605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H73_RS08610	COG2070	2-Nitropropane dioxygenase
I6H73_RS08630	COG1024	Enoyl-CoA hydratase
I6H73_RS08635	COG0484	heat shock protein binding
I6H73_RS08655	COG1420	regulation of RNA biosynthetic process
I6H73_RS08670	COG0588	phosphoglycerate mutase activity
I6H73_RS08675	COG2261	transglycosylase associated protein
I6H73_RS08680	COG0697	spore germination
I6H73_RS08700	COG0574	Belongs to the PEP-utilizing enzyme family
I6H73_RS08700	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H73_RS08705	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H73_RS08710	COG0517	IMP dehydrogenase activity
I6H73_RS08720	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H73_RS08730	COG1937	Protein conserved in bacteria
I6H73_RS08735	COG1335	isochorismatase
I6H73_RS08745	COG0436	Aminotransferase
I6H73_RS08755	COG0561	phosphatase activity
I6H73_RS08760	COG0252	asparaginase activity
I6H73_RS08765	COG4989	oxidoreductase activity
I6H73_RS08770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H73_RS08775	COG1129	ABC transporter
I6H73_RS08790	COG1132	(ABC) transporter
I6H73_RS08795	COG4988	ABC transporter
I6H73_RS08800	COG1120	ATPase activity
I6H73_RS08825	COG3942	CHAP domain
I6H73_RS08825	COG1388	LysM domain
I6H73_RS08845	COG1482	cell wall glycoprotein biosynthetic process
I6H73_RS08850	COG1940	carbohydrate kinase activity
I6H73_RS08855	COG1263	PTS System
I6H73_RS08855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H73_RS08855	COG2190	(PTS) system
I6H73_RS08860	COG1621	beta-fructofuranosidase activity
I6H73_RS08865	COG1609	Transcriptional regulator
I6H73_RS08885	COG2131	deaminase
I6H73_RS08890	COG0006	proline dipeptidase activity
I6H73_RS08930	COG1194	a g-specific adenine glycosylase
I6H73_RS08935	COG3118	belongs to the thioredoxin family
I6H73_RS08940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H73_RS08965	COG0681	Belongs to the peptidase S26 family
I6H73_RS08970	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H73_RS08985	COG1882	Formate acetyltransferase
I6H73_RS08990	COG2153	protein acetylation
I6H73_RS09000	COG1653	transport
I6H73_RS09010	COG0395	ABC-type sugar transport system, permease component
I6H73_RS09015	COG4209	transmembrane transport
I6H73_RS09025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H73_RS09040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H73_RS09070	COG0789	Transcriptional regulator
I6H73_RS09085	COG2081	HI0933 family
I6H73_RS09120	COG1214	PFAM Peptidase M22, glycoprotease
I6H73_RS09125	COG5503	Protein of unknown function (DUF1447)
I6H73_RS09135	COG4608	Belongs to the ABC transporter superfamily
I6H73_RS09140	COG0444	Belongs to the ABC transporter superfamily
I6H73_RS09145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H73_RS09150	COG0601	transmembrane transport
I6H73_RS09155	COG4166	transmembrane transport
I6H73_RS09160	COG0174	glutamine synthetase
I6H73_RS09165	COG0789	Transcriptional regulator
I6H73_RS09180	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6H73_RS09210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H73_RS09225	COG1564	THIamine pyrophosphokinase
I6H73_RS09250	COG0084	hydrolase, TatD family'
I6H73_RS09255	COG1335	isochorismatase
I6H73_RS09270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H73_RS09285	COG0395	ABC-type sugar transport system, permease component
I6H73_RS09290	COG1175	transmembrane transport
I6H73_RS09310	COG1847	R3H domain protein
I6H73_RS09375	COG0756	dUTP diphosphatase activity
I6H73_RS09385	COG1132	(ABC) transporter
I6H73_RS09390	COG1132	(ABC) transporter
I6H73_RS09405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H73_RS09415	COG0705	Rhomboid family
I6H73_RS09415	COG0457	Tetratricopeptide repeat
I6H73_RS09420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H73_RS09455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H73_RS09570	COG0740	serine-type endopeptidase activity
I6H73_RS09600	COG0582	viral genome integration into host DNA
I6H73_RS09665	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6H73_RS09695	COG0305	Participates in initiation and elongation during chromosome replication
I6H73_RS09725	COG1396	sequence-specific DNA binding
I6H73_RS09740	COG0582	viral genome integration into host DNA
I6H73_RS09760	COG4869	propanediol catabolic process
I6H73_RS09765	COG1012	belongs to the aldehyde dehydrogenase family
I6H73_RS09765	COG1454	alcohol dehydrogenase
I6H73_RS09775	COG4766	ethanolamine catabolic process
I6H73_RS09780	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6H73_RS09810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H73_RS09815	COG1882	Formate acetyltransferase
I6H73_RS09820	COG1454	alcohol dehydrogenase
I6H73_RS09820	COG1012	belongs to the aldehyde dehydrogenase family
I6H73_RS09825	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6H73_RS09830	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6H73_RS09850	COG4978	Transcriptional regulator
I6H73_RS09850	COG0789	Transcriptional regulator
I6H73_RS09870	COG1234	tRNA 3'-trailer cleavage
I6H73_RS09875	COG1268	BioY protein
I6H73_RS09900	COG1832	CoA-binding protein
I6H73_RS09905	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H73_RS09905	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H73_RS09915	COG4175	Glycine betaine
I6H73_RS09915	COG3448	diguanylate cyclase activity
I6H73_RS09920	COG1597	lipid kinase activity
I6H73_RS09940	COG3623	hexulose-6-phosphate isomerase
I6H73_RS09990	COG1132	(ABC) transporter
I6H73_RS09995	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6H73_RS10045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H73_RS10060	COG0564	pseudouridine synthase activity
I6H73_RS10075	COG1051	belongs to the nudix hydrolase family
I6H73_RS10090	COG0542	response to heat
I6H73_RS10095	COG4463	regulation of RNA biosynthetic process
I6H73_RS10120	COG0450	alkyl hydroperoxide reductase
I6H73_RS10135	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6H73_RS10145	COG3404	Formiminotransferase-cyclodeaminase
I6H73_RS10160	COG0531	amino acid
I6H73_RS10190	COG3590	peptidase
I6H73_RS10195	COG0366	Alpha amylase catalytic
I6H73_RS10200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H73_RS10200	COG1263	PTS System
I6H73_RS10205	COG2188	Transcriptional regulator
I6H73_RS10210	COG1733	regulation of RNA biosynthetic process
I6H73_RS10215	COG2514	catechol 2,3-dioxygenase activity
I6H73_RS10225	COG0602	queuosine metabolic process
I6H73_RS10265	COG4472	Bacterial protein of unknown function (DUF965)
I6H73_RS10270	COG1393	Belongs to the ArsC family
I6H73_RS10290	COG0519	Catalyzes the synthesis of GMP from XMP
I6H73_RS10300	COG2814	Major facilitator Superfamily
I6H73_RS10310	COG0582	viral genome integration into host DNA
I6H73_RS10445	COG0488	(ABC) transporter
I6H73_RS10450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H73_RS10455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H73_RS10460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H73_RS10565	COG1511	domain protein
I6H73_RS10650	COG0582	viral genome integration into host DNA
I6H73_RS10655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H73_RS10670	COG0305	Participates in initiation and elongation during chromosome replication
I6H73_RS10695	COG2095	MarC family integral membrane protein
I6H73_RS10705	COG1760	l-serine dehydratase
I6H73_RS10710	COG1760	l-serine dehydratase
I6H73_RS10720	COG0741	lytic transglycosylase activity
I6H73_RS10740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H73_RS10750	COG0612	Peptidase, M16
I6H73_RS10775	COG0517	IMP dehydrogenase activity
I6H73_RS10775	COG0516	GMP reductase activity
I6H73_RS10785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H73_RS10790	COG0488	(ABC) transporter
I6H73_RS10825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H73_RS10840	COG0592	DNA-directed DNA polymerase activity
I6H73_RS10855	COG0012	GTP binding
I6H73_RS10865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H73_RS10870	COG2244	polysaccharide biosynthetic process
I6H73_RS10875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H73_RS10900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H73_RS10905	COG0531	amino acid
I6H73_RS11090	COG3942	CHAP domain
I6H73_RS11110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H73_RS11115	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H73_RS11120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H73_RS11130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H73_RS11135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H73_RS11150	COG3942	CHAP domain
I6H73_RS11155	COG0151	Belongs to the GarS family
I6H73_RS11160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H73_RS11180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H73_RS11200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H73_RS11215	COG1012	belongs to the aldehyde dehydrogenase family
I6H73_RS11215	COG1454	alcohol dehydrogenase
I6H73_RS11220	COG1064	alcohol dehydrogenase
I6H73_RS11225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H73_RS11245	COG0051	transcription antitermination factor activity, RNA binding
I6H73_RS11345	COG0200	Binds to the 23S rRNA
I6H73_RS11350	COG0201	protein transport
I6H73_RS11370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H73_RS11480	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6H73_RS11490	COG1252	NADH dehydrogenase
I6H73_RS11495	COG1271	oxidase subunit
I6H73_RS11500	COG1294	oxidase, subunit
I6H73_RS11505	COG4988	ABC transporter
I6H73_RS11510	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H73_RS11515	COG0142	geranyltranstransferase activity