locus-tag	class	description
I6H74_RS00040	COG1346	cytolysis
I6H74_RS00050	COG3279	Response regulator of the LytR AlgR family
I6H74_RS00065	COG3343	RNA polymerase activity
I6H74_RS00075	COG0366	Alpha amylase catalytic
I6H74_RS00080	COG0366	Alpha amylase catalytic
I6H74_RS00085	COG0668	transmembrane transport
I6H74_RS00095	COG4720	Psort location CytoplasmicMembrane, score
I6H74_RS00100	COG0351	phosphomethylpyrimidine kinase
I6H74_RS00110	COG0527	aspartate kinase activity
I6H74_RS00155	COG0561	phosphatase activity
I6H74_RS00175	COG3414	Phosphotransferase system galactitol-specific IIB component
I6H74_RS00180	COG3775	system Galactitol-specific IIC component
I6H74_RS00205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H74_RS00220	COG1476	TRANSCRIPTIONal
I6H74_RS00240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H74_RS00260	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6H74_RS00275	COG1045	serine acetyltransferase
I6H74_RS00290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6H74_RS00305	COG3711	transcriptional antiterminator
I6H74_RS00330	COG0431	NADPH-dependent FMN reductase
I6H74_RS00335	COG1846	Transcriptional regulator
I6H74_RS00360	COG4589	Belongs to the CDS family
I6H74_RS00370	COG1862	Preprotein translocase
I6H74_RS00385	COG1523	belongs to the glycosyl hydrolase 13 family
I6H74_RS00395	COG3842	ATPase activity
I6H74_RS00420	COG0737	Belongs to the 5'-nucleotidase family
I6H74_RS00450	COG1363	Peptidase, m42
I6H74_RS00465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H74_RS00465	COG1263	PTS System
I6H74_RS00465	COG2190	(PTS) system
I6H74_RS00470	COG1609	Transcriptional regulator
I6H74_RS00475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H74_RS00505	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H74_RS00510	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H74_RS00515	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H74_RS00595	COG1132	(ABC) transporter
I6H74_RS00645	COG0488	(ABC) transporter
I6H74_RS00660	COG3655	Transcriptional regulator
I6H74_RS00685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6H74_RS00705	COG1882	Formate acetyltransferase
I6H74_RS00710	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H74_RS00715	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H74_RS00720	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6H74_RS00725	COG2390	Transcriptional regulator
I6H74_RS00730	COG1349	DNA-binding transcription factor activity
I6H74_RS00735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H74_RS00740	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H74_RS00765	COG0251	oxidation-reduction process
I6H74_RS00840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H74_RS00845	COG1428	Deoxynucleoside kinase
I6H74_RS00860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H74_RS00865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H74_RS00875	COG1363	Peptidase, m42
I6H74_RS00880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H74_RS00890	COG1266	CAAX protease self-immunity
I6H74_RS00930	COG4537	Required for transformation and DNA binding
I6H74_RS00935	COG1459	type II secretion system
I6H74_RS00940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H74_RS00960	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6H74_RS00960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H74_RS00970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H74_RS00975	COG1121	(ABC) transporter
I6H74_RS00990	COG0142	geranyltranstransferase activity
I6H74_RS00995	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6H74_RS01000	COG4988	ABC transporter
I6H74_RS01005	COG1294	oxidase, subunit
I6H74_RS01010	COG1271	oxidase subunit
I6H74_RS01015	COG1252	NADH dehydrogenase
I6H74_RS01025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6H74_RS01130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6H74_RS01150	COG0201	protein transport
I6H74_RS01155	COG0200	Binds to the 23S rRNA
I6H74_RS01255	COG0051	transcription antitermination factor activity, RNA binding
I6H74_RS01275	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6H74_RS01280	COG1064	alcohol dehydrogenase
I6H74_RS01285	COG1454	alcohol dehydrogenase
I6H74_RS01285	COG1012	belongs to the aldehyde dehydrogenase family
I6H74_RS01300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6H74_RS01320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H74_RS01335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H74_RS01345	COG0151	Belongs to the GarS family
I6H74_RS01350	COG3942	CHAP domain
I6H74_RS01365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H74_RS01370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H74_RS01380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H74_RS01385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H74_RS01395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H74_RS01415	COG3942	CHAP domain
I6H74_RS01595	COG0531	amino acid
I6H74_RS01600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H74_RS01625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H74_RS01630	COG2244	polysaccharide biosynthetic process
I6H74_RS01635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H74_RS01645	COG0012	GTP binding
I6H74_RS01660	COG0592	DNA-directed DNA polymerase activity
I6H74_RS01675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H74_RS01710	COG0488	(ABC) transporter
I6H74_RS01715	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H74_RS01725	COG0516	GMP reductase activity
I6H74_RS01725	COG0517	IMP dehydrogenase activity
I6H74_RS01755	COG0612	Peptidase, M16
I6H74_RS01765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6H74_RS01785	COG0741	lytic transglycosylase activity
I6H74_RS01795	COG1760	l-serine dehydratase
I6H74_RS01800	COG1760	l-serine dehydratase
I6H74_RS01810	COG2095	MarC family integral membrane protein
I6H74_RS01835	COG0305	Participates in initiation and elongation during chromosome replication
I6H74_RS01850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6H74_RS01855	COG0582	viral genome integration into host DNA
I6H74_RS01935	COG1511	domain protein
I6H74_RS02020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H74_RS02025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H74_RS02030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H74_RS02035	COG0488	(ABC) transporter
I6H74_RS02065	COG2814	Major facilitator Superfamily
I6H74_RS02075	COG0519	Catalyzes the synthesis of GMP from XMP
I6H74_RS02100	COG1393	Belongs to the ArsC family
I6H74_RS02105	COG4472	Bacterial protein of unknown function (DUF965)
I6H74_RS02145	COG0602	queuosine metabolic process
I6H74_RS02160	COG1733	regulation of RNA biosynthetic process
I6H74_RS02165	COG2188	Transcriptional regulator
I6H74_RS02170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H74_RS02170	COG1263	PTS System
I6H74_RS02175	COG0366	Alpha amylase catalytic
I6H74_RS02180	COG3590	peptidase
I6H74_RS02195	COG5433	transposase activity
I6H74_RS02215	COG0531	amino acid
I6H74_RS02230	COG3404	Formiminotransferase-cyclodeaminase
I6H74_RS02240	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6H74_RS02255	COG0450	alkyl hydroperoxide reductase
I6H74_RS02280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6H74_RS02325	COG4463	regulation of RNA biosynthetic process
I6H74_RS02330	COG0542	response to heat
I6H74_RS02345	COG1051	belongs to the nudix hydrolase family
I6H74_RS02360	COG0564	pseudouridine synthase activity
I6H74_RS02375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H74_RS02445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H74_RS02455	COG3623	hexulose-6-phosphate isomerase
I6H74_RS02475	COG1597	lipid kinase activity
I6H74_RS02480	COG4175	Glycine betaine
I6H74_RS02480	COG3448	diguanylate cyclase activity
I6H74_RS02490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H74_RS02490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H74_RS02495	COG1832	CoA-binding protein
I6H74_RS02520	COG1268	BioY protein
I6H74_RS02525	COG1234	tRNA 3'-trailer cleavage
I6H74_RS02540	COG5433	transposase activity
I6H74_RS02565	COG1396	sequence-specific DNA binding
I6H74_RS02590	COG3620	sequence-specific DNA binding
I6H74_RS02660	COG3942	CHAP domain
I6H74_RS02660	COG1388	LysM domain
I6H74_RS02710	COG3843	relaxase mobilization nuclease domain protein
I6H74_RS02740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H74_RS02775	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H74_RS02780	COG0705	Rhomboid family
I6H74_RS02780	COG0457	Tetratricopeptide repeat
I6H74_RS02790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H74_RS02805	COG1132	(ABC) transporter
I6H74_RS02810	COG1132	(ABC) transporter
I6H74_RS02820	COG0756	dUTP diphosphatase activity
I6H74_RS02885	COG1847	R3H domain protein
I6H74_RS02905	COG1175	transmembrane transport
I6H74_RS02910	COG0395	ABC-type sugar transport system, permease component
I6H74_RS02925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H74_RS02940	COG1335	isochorismatase
I6H74_RS02945	COG2814	Major facilitator Superfamily
I6H74_RS02955	COG2814	Major facilitator Superfamily
I6H74_RS02960	COG0084	hydrolase, TatD family'
I6H74_RS02985	COG1564	THIamine pyrophosphokinase
I6H74_RS03000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H74_RS03030	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6H74_RS03045	COG0789	Transcriptional regulator
I6H74_RS03050	COG0174	glutamine synthetase
I6H74_RS03055	COG4166	transmembrane transport
I6H74_RS03060	COG0601	transmembrane transport
I6H74_RS03065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H74_RS03070	COG0444	Belongs to the ABC transporter superfamily
I6H74_RS03075	COG4608	Belongs to the ABC transporter superfamily
I6H74_RS03085	COG5503	Protein of unknown function (DUF1447)
I6H74_RS03090	COG1214	PFAM Peptidase M22, glycoprotease
I6H74_RS03115	COG2081	HI0933 family
I6H74_RS03120	COG5433	transposase activity
I6H74_RS03135	COG0789	Transcriptional regulator
I6H74_RS03165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H74_RS03180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H74_RS03190	COG4209	transmembrane transport
I6H74_RS03195	COG0395	ABC-type sugar transport system, permease component
I6H74_RS03205	COG1653	transport
I6H74_RS03215	COG2153	protein acetylation
I6H74_RS03220	COG1882	Formate acetyltransferase
I6H74_RS03235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H74_RS03240	COG0681	Belongs to the peptidase S26 family
I6H74_RS03265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H74_RS03270	COG3118	belongs to the thioredoxin family
I6H74_RS03280	COG1194	a g-specific adenine glycosylase
I6H74_RS03315	COG0006	proline dipeptidase activity
I6H74_RS03320	COG2131	deaminase
I6H74_RS03340	COG1609	Transcriptional regulator
I6H74_RS03345	COG1621	beta-fructofuranosidase activity
I6H74_RS03350	COG1263	PTS System
I6H74_RS03350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H74_RS03350	COG2190	(PTS) system
I6H74_RS03355	COG1940	carbohydrate kinase activity
I6H74_RS03360	COG1482	cell wall glycoprotein biosynthetic process
I6H74_RS03380	COG3942	CHAP domain
I6H74_RS03380	COG1388	LysM domain
I6H74_RS03405	COG1120	ATPase activity
I6H74_RS03410	COG4988	ABC transporter
I6H74_RS03415	COG1132	(ABC) transporter
I6H74_RS03430	COG1129	ABC transporter
I6H74_RS03435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H74_RS03440	COG4989	oxidoreductase activity
I6H74_RS03445	COG0252	asparaginase activity
I6H74_RS03450	COG0561	phosphatase activity
I6H74_RS03460	COG0436	Aminotransferase
I6H74_RS03470	COG1335	isochorismatase
I6H74_RS03475	COG1937	Protein conserved in bacteria
I6H74_RS03485	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H74_RS03495	COG0517	IMP dehydrogenase activity
I6H74_RS03500	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6H74_RS03505	COG0574	Belongs to the PEP-utilizing enzyme family
I6H74_RS03505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6H74_RS03510	COG5433	transposase activity
I6H74_RS03530	COG0697	spore germination
I6H74_RS03535	COG2261	transglycosylase associated protein
I6H74_RS03540	COG0588	phosphoglycerate mutase activity
I6H74_RS03555	COG1420	regulation of RNA biosynthetic process
I6H74_RS03575	COG0484	heat shock protein binding
I6H74_RS03580	COG1024	Enoyl-CoA hydratase
I6H74_RS03600	COG2070	2-Nitropropane dioxygenase
I6H74_RS03605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H74_RS03610	COG1028	Short-chain dehydrogenase reductase Sdr
I6H74_RS03615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H74_RS03630	COG0439	Biotin carboxylase
I6H74_RS03660	COG3716	PTS system mannose fructose sorbose family IID component
I6H74_RS03665	COG3715	PTS system
I6H74_RS03675	COG0561	phosphatase activity
I6H74_RS03680	COG2252	PERMEase
I6H74_RS03685	COG0802	atpase or kinase
I6H74_RS03690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H74_RS03695	COG1316	TRANSCRIPTIONal
I6H74_RS03705	COG0537	adenosine 5'-monophosphoramidase activity
I6H74_RS03710	COG1131	(ABC) transporter
I6H74_RS03715	COG4473	ABC transporter
I6H74_RS03740	COG0195	Participates in both transcription termination and antitermination
I6H74_RS03745	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H74_RS03775	COG0662	Cupin 2, conserved barrel domain protein
I6H74_RS03775	COG2207	Transcriptional regulator
I6H74_RS03795	COG4509	Sortase family
I6H74_RS03815	COG2217	Heavy metal translocating P-type atpase
I6H74_RS03830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H74_RS03860	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H74_RS03870	COG2860	membrane
I6H74_RS03875	COG0561	phosphatase activity
I6H74_RS03895	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6H74_RS03905	COG0656	L-ascorbic acid biosynthetic process
I6H74_RS03910	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6H74_RS03945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H74_RS03950	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H74_RS03975	COG1131	(ABC) transporter
I6H74_RS04005	COG0768	penicillin binding
I6H74_RS04015	COG0513	Belongs to the DEAD box helicase family
I6H74_RS04025	COG0765	amino acid transport
I6H74_RS04030	COG1126	abc transporter atp-binding protein
I6H74_RS04040	COG0492	ferredoxin-NADP+ reductase activity
I6H74_RS04045	COG1113	amino acid transport
I6H74_RS04050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H74_RS04060	COG3579	cysteine-type endopeptidase activity
I6H74_RS04065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H74_RS04090	COG0116	Belongs to the methyltransferase superfamily
I6H74_RS04120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6H74_RS04125	COG0183	Belongs to the thiolase family
I6H74_RS04150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H74_RS04160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H74_RS04160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H74_RS04170	COG0515	serine threonine protein kinase
I6H74_RS04170	COG2815	serine threonine protein kinase
I6H74_RS04180	COG4585	Histidine kinase
I6H74_RS04185	COG2197	response regulator
I6H74_RS04195	COG1098	S1 RNA binding domain
I6H74_RS04205	COG1739	Uncharacterized protein family UPF0029
I6H74_RS04210	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6H74_RS04215	COG1040	competence protein
I6H74_RS04305	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6H74_RS04305	COG1024	Enoyl-CoA hydratase
I6H74_RS04310	COG0183	Belongs to the thiolase family
I6H74_RS04315	COG2070	2-Nitropropane dioxygenase
I6H74_RS04325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6H74_RS04340	COG0383	alpha-mannosidase activity
I6H74_RS04355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I6H74_RS04360	COG2723	6-phospho-beta-galactosidase activity
I6H74_RS04375	COG1940	carbohydrate kinase activity
I6H74_RS04380	COG1175	transmembrane transport
I6H74_RS04385	COG0395	ABC-type sugar transport system, permease component
I6H74_RS04390	COG1653	transport
I6H74_RS04400	COG2972	Histidine kinase
I6H74_RS04405	COG2207	Transcriptional regulator
I6H74_RS04405	COG4753	response regulator
I6H74_RS04410	COG3250	beta-galactosidase activity
I6H74_RS04445	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6H74_RS04445	COG1605	Chorismate mutase
I6H74_RS04455	COG0534	Mate efflux family protein
I6H74_RS04475	COG0346	lactoylglutathione lyase activity
I6H74_RS04520	COG1518	maintenance of DNA repeat elements
I6H74_RS04525	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6H74_RS04530	COG0673	inositol 2-dehydrogenase activity
I6H74_RS04540	COG0785	Cytochrome C biogenesis protein
I6H74_RS04545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H74_RS04560	COG2972	Histidine kinase
I6H74_RS04580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H74_RS04585	COG2235	arginine
I6H74_RS04590	COG0454	-acetyltransferase
I6H74_RS04600	COG1288	antiporter activity
I6H74_RS04605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H74_RS04615	COG0549	Belongs to the carbamate kinase family
I6H74_RS04625	COG0742	ribosomal rna small subunit methyltransferase
I6H74_RS04635	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6H74_RS04640	COG1609	Transcriptional regulator
I6H74_RS04645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6H74_RS04650	COG1869	D-ribose catabolic process
I6H74_RS04660	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6H74_RS04665	COG1879	ABC-type sugar transport system periplasmic component
I6H74_RS04680	COG4470	Protein conserved in bacteria
I6H74_RS04685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6H74_RS04695	COG1132	(ABC) transporter
I6H74_RS04700	COG1132	(ABC) transporter
I6H74_RS04705	COG1131	(ABC) transporter
I6H74_RS04740	COG1078	dGTPase activity
I6H74_RS04760	COG1609	Transcriptional regulator
I6H74_RS04770	COG3716	PTS system mannose fructose sorbose family IID component
I6H74_RS04775	COG3715	PTS system
I6H74_RS04780	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H74_RS04795	COG1028	Short-chain dehydrogenase reductase Sdr
I6H74_RS04815	COG5492	domain, Protein
I6H74_RS04835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H74_RS04840	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6H74_RS04845	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6H74_RS04855	COG2884	Cell division ATP-binding protein ftsE
I6H74_RS04860	COG2177	Part of the ABC transporter FtsEX involved in
I6H74_RS04870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H74_RS04870	COG1199	ATP-dependent helicase activity
I6H74_RS04875	COG0436	Aminotransferase
I6H74_RS04880	COG0017	Asparaginyl-tRNA synthetase
I6H74_RS04915	COG2188	Transcriptional regulator
I6H74_RS04920	COG2222	sugar isomerase
I6H74_RS04945	COG3715	PTS system
I6H74_RS04950	COG3716	PTS system mannose fructose sorbose family IID component
I6H74_RS04970	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H74_RS04975	COG2153	protein acetylation
I6H74_RS04990	COG0716	FMN binding
I6H74_RS05000	COG0038	chloride channel
I6H74_RS05015	COG0772	Belongs to the SEDS family
I6H74_RS05035	COG0560	Phosphoserine phosphatase
I6H74_RS05140	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
I6H74_RS05145	COG3620	sequence-specific DNA binding
I6H74_RS05190	COG1131	(ABC) transporter
I6H74_RS05210	COG4708	membrane
I6H74_RS05220	COG1597	lipid kinase activity
I6H74_RS05225	COG1523	belongs to the glycosyl hydrolase 13 family
I6H74_RS05230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6H74_RS05235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H74_RS05240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6H74_RS05330	COG0577	efflux transmembrane transporter activity
I6H74_RS05340	COG2321	neutral zinc metallopeptidase
I6H74_RS05355	COG0436	Aminotransferase
I6H74_RS05370	COG1970	mechanosensitive ion channel activity
I6H74_RS05375	COG0358	DNA primase activity
I6H74_RS05380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H74_RS05385	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H74_RS05400	COG1216	Glycosyl transferase, family 2
I6H74_RS05400	COG1442	glycosyl transferase family 8
I6H74_RS05425	COG0463	Glycosyl transferase, family 2
I6H74_RS05440	COG0438	transferase activity, transferring glycosyl groups
I6H74_RS05445	COG1368	sulfuric ester hydrolase activity
I6H74_RS05450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H74_RS05500	COG1368	sulfuric ester hydrolase activity
I6H74_RS05505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6H74_RS05525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H74_RS05530	COG0285	dihydrofolate synthase activity
I6H74_RS05540	COG1104	cysteine desulfurase activity
I6H74_RS05570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H74_RS05575	COG0583	DNA-binding transcription factor activity
I6H74_RS05585	COG0564	pseudouridine synthase activity
I6H74_RS05620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H74_RS05625	COG1136	(ABC) transporter
I6H74_RS05630	COG0577	efflux transmembrane transporter activity
I6H74_RS05640	COG0584	glycerophosphoryl diester phosphodiesterase
I6H74_RS05650	COG1837	Belongs to the UPF0109 family
I6H74_RS05685	COG1349	DNA-binding transcription factor activity
I6H74_RS05690	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H74_RS05695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H74_RS05695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H74_RS05695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H74_RS05700	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H74_RS05700	COG1388	LysM domain
I6H74_RS05705	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H74_RS05705	COG1388	LysM domain
I6H74_RS05730	COG0488	(ABC) transporter
I6H74_RS05740	COG1132	(ABC) transporter
I6H74_RS05745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H74_RS05750	COG0242	peptide deformylase activity
I6H74_RS05755	COG0737	Belongs to the 5'-nucleotidase family
I6H74_RS05760	COG1132	(ABC) transporter
I6H74_RS05765	COG1132	(ABC) transporter
I6H74_RS05815	COG3425	synthase
I6H74_RS05825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H74_RS05885	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6H74_RS06045	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H74_RS06055	COG1131	(ABC) transporter
I6H74_RS06060	COG0842	Transport permease protein
I6H74_RS06075	COG2217	Heavy metal translocating P-type atpase
I6H74_RS06080	COG0640	Transcriptional regulator
I6H74_RS06095	COG1388	LysM domain
I6H74_RS06095	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6H74_RS06135	COG2217	Heavy metal translocating P-type atpase
I6H74_RS06140	COG2217	Heavy metal translocating P-type atpase
I6H74_RS06200	COG1396	sequence-specific DNA binding
I6H74_RS06210	COG4974	Belongs to the 'phage' integrase family
I6H74_RS06215	COG1686	Belongs to the peptidase S11 family
I6H74_RS06220	COG0726	polysaccharide deacetylase
I6H74_RS06235	COG0285	dihydrofolate synthase activity
I6H74_RS06240	COG0302	gtp cyclohydrolase
I6H74_RS06255	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6H74_RS06270	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H74_RS06275	COG1177	transmembrane transport
I6H74_RS06300	COG3493	citrate carrier protein
I6H74_RS06310	COG0038	chloride channel
I6H74_RS06315	COG4977	sequence-specific DNA binding
I6H74_RS06315	COG1917	Cupin 2, conserved barrel domain protein
I6H74_RS06325	COG0628	permease
I6H74_RS06335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6H74_RS06355	COG1104	cysteine desulfurase activity
I6H74_RS06370	COG2357	RelA SpoT domain protein
I6H74_RS06380	COG0564	pseudouridine synthase activity
I6H74_RS06385	COG0280	phosphate acetyltransferase
I6H74_RS06390	COG4221	oxidoreductase activity
I6H74_RS06405	COG1174	glycine betaine transport
I6H74_RS06420	COG2233	PERMEase
I6H74_RS06430	COG1942	4-Oxalocrotonate Tautomerase
I6H74_RS06445	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H74_RS06450	COG0009	L-threonylcarbamoyladenylate synthase
I6H74_RS06475	COG1132	(ABC) transporter
I6H74_RS06480	COG1132	(ABC) transporter
I6H74_RS06490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H74_RS06505	COG3764	Sortase (surface protein transpeptidase)
I6H74_RS06510	COG0346	lactoylglutathione lyase activity
I6H74_RS06515	COG5433	transposase activity
I6H74_RS06570	COG1136	(ABC) transporter
I6H74_RS06575	COG0577	efflux transmembrane transporter activity
I6H74_RS06580	COG0745	RESPONSE REGULATOR receiver
I6H74_RS06585	COG2205	protein histidine kinase activity
I6H74_RS06590	COG3942	CHAP domain
I6H74_RS06590	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H74_RS06610	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6H74_RS06630	COG1122	ATPase activity
I6H74_RS06640	COG0601	transmembrane transport
I6H74_RS06675	COG2188	Transcriptional regulator
I6H74_RS06685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H74_RS06700	COG0673	inositol 2-dehydrogenase activity
I6H74_RS06710	COG5002	protein histidine kinase activity
I6H74_RS06715	COG0662	Cupin 2, conserved barrel domain protein
I6H74_RS06745	COG4939	FMN-binding domain protein
I6H74_RS06750	COG0142	geranyltranstransferase activity
I6H74_RS06755	COG1252	NADH dehydrogenase
I6H74_RS06760	COG5433	transposase activity
I6H74_RS06770	COG5002	protein histidine kinase activity
I6H74_RS06775	COG0745	RESPONSE REGULATOR receiver
I6H74_RS06780	COG0577	efflux transmembrane transporter activity
I6H74_RS06785	COG1136	(ABC) transporter
I6H74_RS06800	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6H74_RS06835	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6H74_RS06840	COG0511	ligase activity, forming carbon-carbon bonds
I6H74_RS06850	COG2851	Citrate transporter
I6H74_RS06870	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6H74_RS06875	COG0511	ligase activity, forming carbon-carbon bonds
I6H74_RS06925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H74_RS06930	COG0758	DNA mediated transformation
I6H74_RS06955	COG1272	protein, Hemolysin III
I6H74_RS06975	COG0488	(ABC) transporter
I6H74_RS06995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H74_RS07000	COG1328	CTP reductase activity
I6H74_RS07000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H74_RS07005	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H74_RS07010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H74_RS07065	COG0095	Lipoate-protein ligase
I6H74_RS07075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H74_RS07080	COG4684	Psort location CytoplasmicMembrane, score
I6H74_RS07085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H74_RS07090	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H74_RS07095	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H74_RS07100	COG3845	ABC transporter
I6H74_RS07105	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H74_RS07120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6H74_RS07125	COG2813	Specifically methylates the guanine in position
I6H74_RS07140	COG5002	protein histidine kinase activity
I6H74_RS07145	COG0745	RESPONSE REGULATOR receiver
I6H74_RS07155	COG0704	Plays a role in the regulation of phosphate uptake
I6H74_RS07170	COG0581	inorganic phosphate transmembrane transporter activity
I6H74_RS07175	COG0573	inorganic phosphate transmembrane transporter activity
I6H74_RS07185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H74_RS07185	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6H74_RS07190	COG0483	inositol monophosphate 1-phosphatase activity
I6H74_RS07205	COG0196	riboflavin kinase activity
I6H74_RS07235	COG1136	(ABC) transporter
I6H74_RS07235	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6H74_RS07275	COG2261	transglycosylase associated protein
I6H74_RS07285	COG1115	amino acid carrier protein
I6H74_RS07290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H74_RS07300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H74_RS07305	COG1126	abc transporter atp-binding protein
I6H74_RS07310	COG0765	amino acid transport
I6H74_RS07315	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H74_RS07330	COG0469	pyruvate kinase activity
I6H74_RS07345	COG1725	Transcriptional regulator
I6H74_RS07350	COG1131	(ABC) transporter
I6H74_RS07360	COG0398	Pfam SNARE associated Golgi protein
I6H74_RS07385	COG0539	negative regulation of cytoplasmic translation
I6H74_RS07410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H74_RS07430	COG0187	DNA topoisomerase II activity
I6H74_RS07450	COG0765	amino acid transport
I6H74_RS07505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6H74_RS07535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H74_RS07545	COG0028	Belongs to the TPP enzyme family
I6H74_RS07550	COG0028	Belongs to the TPP enzyme family
I6H74_RS07570	COG1012	belongs to the aldehyde dehydrogenase family
I6H74_RS07575	COG1011	Hydrolase
I6H74_RS07605	COG4753	response regulator
I6H74_RS07605	COG2207	Transcriptional regulator
I6H74_RS07610	COG2972	Histidine kinase
I6H74_RS07615	COG3716	PTS system mannose fructose sorbose family IID component
I6H74_RS07620	COG3715	PTS system
I6H74_RS07655	COG1418	mRNA catabolic process
I6H74_RS07680	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6H74_RS07685	COG1518	maintenance of DNA repeat elements
I6H74_RS07700	COG0647	UMP catabolic process
I6H74_RS07710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H74_RS07730	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6H74_RS07735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H74_RS07740	COG3442	glutamine amidotransferase
I6H74_RS07745	COG0095	Lipoate-protein ligase
I6H74_RS07755	COG1695	Transcriptional regulator
I6H74_RS07770	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H74_RS07770	COG0022	dehydrogenase e1 component
I6H74_RS07775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6H74_RS07780	COG0488	(ABC) transporter
I6H74_RS07800	COG1122	ATPase activity
I6H74_RS07830	COG3700	Belongs to the class B bacterial acid phosphatase family
I6H74_RS07850	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6H74_RS07855	COG0457	Tetratricopeptide repeat
I6H74_RS07860	COG0628	permease
I6H74_RS07865	COG1051	belongs to the nudix hydrolase family
I6H74_RS07885	COG1088	dTDP-glucose 4,6-dehydratase activity
I6H74_RS07895	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6H74_RS07900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6H74_RS07915	COG2384	SAM-dependent methyltransferase
I6H74_RS07920	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H74_RS07935	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H74_RS07935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H74_RS07940	COG0300	oxidoreductase activity
I6H74_RS07955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H74_RS07985	COG1054	Belongs to the UPF0176 family
I6H74_RS07995	COG0431	NADPH-dependent FMN reductase
I6H74_RS08000	COG0058	SHG alpha-glucan phosphorylase activity
I6H74_RS08005	COG1640	4-alpha-glucanotransferase
I6H74_RS08010	COG1609	Transcriptional regulator
I6H74_RS08020	COG2182	Extracellular solute-binding protein
I6H74_RS08030	COG3833	ABC-type maltose transport systems, permease component
I6H74_RS08060	COG0366	Alpha amylase catalytic
I6H74_RS08065	COG2182	Extracellular solute-binding protein
I6H74_RS08070	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6H74_RS08080	COG1696	Membrane protein involved in D-alanine export
I6H74_RS08095	COG0556	nucleotide-excision repair
I6H74_RS08100	COG0765	amino acid transport
I6H74_RS08105	COG1126	abc transporter atp-binding protein
I6H74_RS08130	COG2309	aminopeptidase activity
I6H74_RS08140	COG1187	pseudouridine synthase activity
I6H74_RS08150	COG2814	Major facilitator Superfamily
I6H74_RS08160	COG0390	transport system, permease component
I6H74_RS08165	COG4619	ABC transporter
I6H74_RS08180	COG1464	Belongs to the NlpA lipoprotein family
I6H74_RS08240	COG4109	DRTGG domain
I6H74_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
I6H74_RS08270	COG1312	Catalyzes the dehydration of D-mannonate
I6H74_RS08280	COG0800	Aldolase
I6H74_RS08285	COG2186	Transcriptional regulator
I6H74_RS08290	COG3250	beta-galactosidase activity
I6H74_RS08300	COG2211	Major facilitator Superfamily
I6H74_RS08320	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6H74_RS08320	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6H74_RS08335	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H74_RS08340	COG1956	GAF domain-containing protein
I6H74_RS08360	COG0513	Belongs to the DEAD box helicase family
I6H74_RS08365	COG0726	polysaccharide deacetylase
I6H74_RS08385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H74_RS08390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H74_RS08395	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H74_RS08415	COG1476	TRANSCRIPTIONal
I6H74_RS08440	COG4122	O-methyltransferase activity
I6H74_RS08445	COG2223	nitrite transmembrane transporter activity
I6H74_RS08460	COG0431	NADPH-dependent FMN reductase
I6H74_RS08480	COG1187	pseudouridine synthase activity
I6H74_RS08515	COG2333	competence protein COMEC
I6H74_RS08515	COG0658	competence protein
I6H74_RS08520	COG1555	photosystem II stabilization
I6H74_RS08520	COG1596	polysaccharide export
I6H74_RS08525	COG0204	Acyl-transferase
I6H74_RS08530	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H74_RS08545	COG0513	Belongs to the DEAD box helicase family
I6H74_RS08550	COG1464	Belongs to the NlpA lipoprotein family
I6H74_RS08560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H74_RS08580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H74_RS08595	COG0768	penicillin binding
I6H74_RS08600	COG2116	formate transmembrane transporter activity
I6H74_RS08610	COG1827	regulation of RNA biosynthetic process
I6H74_RS08630	COG2217	Heavy metal translocating P-type atpase
I6H74_RS08655	COG2755	lipolytic protein G-D-S-L family
I6H74_RS08675	COG0497	DNA recombination
I6H74_RS08680	COG1438	arginine binding
I6H74_RS08685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6H74_RS08705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H74_RS08715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H74_RS08720	COG0415	Belongs to the DNA photolyase family
I6H74_RS08745	COG0765	amino acid transport
I6H74_RS08750	COG4703	Protein of unknown function (DUF1797)
I6H74_RS08755	COG0542	response to heat
I6H74_RS08760	COG1051	belongs to the nudix hydrolase family
I6H74_RS08775	COG3599	regulation of cell shape
I6H74_RS08795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H74_RS08805	COG0849	cell division
I6H74_RS08840	COG1217	gtp-binding protein TYPA
I6H74_RS08880	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H74_RS09000	COG1783	phage Terminase large subunit
I6H74_RS09125	COG3561	AntA/AntB antirepressor
I6H74_RS09150	COG3620	sequence-specific DNA binding
I6H74_RS09160	COG0582	viral genome integration into host DNA
I6H74_RS09165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H74_RS09170	COG1940	carbohydrate kinase activity
I6H74_RS09180	COG0783	Belongs to the Dps family
I6H74_RS09190	COG2197	response regulator
I6H74_RS09195	COG4585	Histidine kinase
I6H74_RS09200	COG0842	Transport permease protein
I6H74_RS09250	COG1191	sigma factor activity
I6H74_RS09255	COG0772	Belongs to the SEDS family
I6H74_RS09265	COG1164	Oligoendopeptidase f
I6H74_RS09270	COG0386	Belongs to the glutathione peroxidase family
I6H74_RS09295	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6H74_RS09345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H74_RS09350	COG3620	sequence-specific DNA binding
I6H74_RS09370	COG3620	sequence-specific DNA binding
I6H74_RS09390	COG1674	ftsk spoiiie
I6H74_RS09440	COG0433	COG0433 Predicted ATPase
I6H74_RS09460	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H74_RS09460	COG3942	CHAP domain
I6H74_RS09470	COG0582	viral genome integration into host DNA
I6H74_RS09475	COG0004	ammonium transporteR
I6H74_RS09490	COG4443	Transcriptional Coactivator p15 (PC4)
I6H74_RS09495	COG0826	peptidase U32
I6H74_RS09540	COG2183	response to ionizing radiation
I6H74_RS09550	COG0704	Plays a role in the regulation of phosphate uptake
I6H74_RS09555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H74_RS09565	COG0573	inorganic phosphate transmembrane transporter activity
I6H74_RS09570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H74_RS09575	COG5002	protein histidine kinase activity
I6H74_RS09580	COG0745	RESPONSE REGULATOR receiver
I6H74_RS09595	COG0701	Predicted permease
I6H74_RS09600	COG3689	TIGRFAM TIGR03943 family protein
I6H74_RS09605	COG0552	protein localization to endoplasmic reticulum
I6H74_RS09610	COG0561	phosphatase activity
I6H74_RS09615	COG0561	phosphatase activity
I6H74_RS09635	COG1196	nuclear chromosome segregation
I6H74_RS09655	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H74_RS09660	COG5002	protein histidine kinase activity
I6H74_RS09665	COG0745	RESPONSE REGULATOR receiver
I6H74_RS09675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H74_RS09680	COG0765	amino acid transport
I6H74_RS09685	COG0765	amino acid transport
I6H74_RS09695	COG0318	PFAM AMP-dependent synthetase and ligase
I6H74_RS09700	COG0183	Belongs to the thiolase family
I6H74_RS09710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6H74_RS09715	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6H74_RS09720	COG1461	Dihydroxyacetone kinase
I6H74_RS09725	COG2376	Dihydroxyacetone kinase
I6H74_RS09735	COG2376	Dihydroxyacetone kinase
I6H74_RS09750	COG4555	ABC transporter
I6H74_RS09760	COG0438	transferase activity, transferring glycosyl groups
I6H74_RS09775	COG1609	Transcriptional regulator
I6H74_RS09780	COG0006	proline dipeptidase activity
I6H74_RS09785	COG0778	Nitroreductase
I6H74_RS09790	COG0346	lactoylglutathione lyase activity
I6H74_RS09800	COG0463	Glycosyl transferase, family 2
I6H74_RS09815	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6H74_RS09820	COG0557	exoribonuclease II activity
I6H74_RS09835	COG2814	Major facilitator Superfamily
I6H74_RS09840	COG0433	COG0433 Predicted ATPase
I6H74_RS09850	COG1131	(ABC) transporter
I6H74_RS09865	COG1396	sequence-specific DNA binding
I6H74_RS09920	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H74_RS09930	COG1573	uracil-dna glycosylase
I6H74_RS09935	COG1702	phosphate starvation-inducible protein PhoH
I6H74_RS10005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6H74_RS10035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H74_RS10060	COG0673	inositol 2-dehydrogenase activity
I6H74_RS10075	COG1028	Short-chain dehydrogenase reductase Sdr
I6H74_RS10090	COG1114	Component of the transport system for branched-chain amino acids
I6H74_RS10130	COG1304	FMN binding
I6H74_RS10135	COG1620	l-lactate permease
I6H74_RS10145	COG0708	Exodeoxyribonuclease III
I6H74_RS10160	COG1393	Belongs to the ArsC family
I6H74_RS10175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6H74_RS10200	COG1774	PSP1 C-terminal conserved region
I6H74_RS10205	COG0470	DNA polymerase III
I6H74_RS10215	COG0517	IMP dehydrogenase activity
I6H74_RS10225	COG0411	ABC transporter
I6H74_RS10235	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6H74_RS10270	COG2244	polysaccharide biosynthetic process
I6H74_RS10280	COG1120	ATPase activity
I6H74_RS10285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H74_RS10290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H74_RS10295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H74_RS10310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H74_RS10315	COG1253	flavin adenine dinucleotide binding
I6H74_RS10320	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H74_RS10325	COG1242	4 iron, 4 sulfur cluster binding
I6H74_RS10330	COG0671	phosphoesterase, PA-phosphatase related
I6H74_RS10335	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6H74_RS10350	COG1187	pseudouridine synthase activity
I6H74_RS10370	COG4175	Glycine betaine
I6H74_RS10405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H74_RS10410	COG1254	Belongs to the acylphosphatase family
I6H74_RS10425	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H74_RS10445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6H74_RS10455	COG1484	DNA-dependent DNA replication
I6H74_RS10465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H74_RS10470	COG5002	protein histidine kinase activity
I6H74_RS10475	COG0745	RESPONSE REGULATOR receiver
I6H74_RS10490	COG1704	LemA family
I6H74_RS10500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H74_RS10505	COG0569	domain protein
I6H74_RS10515	COG1114	Component of the transport system for branched-chain amino acids
I6H74_RS10530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6H74_RS10535	COG1464	Belongs to the NlpA lipoprotein family
I6H74_RS10545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H74_RS10555	COG5433	transposase activity
I6H74_RS10560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6H74_RS10575	COG0789	Transcriptional regulator
I6H74_RS10580	COG1323	Belongs to the UPF0348 family
I6H74_RS10585	COG2226	methyltransferase
I6H74_RS10590	COG0799	negative regulation of ribosome biogenesis
I6H74_RS10600	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H74_RS10610	COG1534	Rna-binding protein
I6H74_RS10615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H74_RS10620	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6H74_RS10680	COG0444	Belongs to the ABC transporter superfamily
I6H74_RS10685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H74_RS10690	COG0601	transmembrane transport
I6H74_RS10695	COG4166	transmembrane transport
I6H74_RS10700	COG1686	Belongs to the peptidase S11 family
I6H74_RS10705	COG1686	Belongs to the peptidase S11 family
I6H74_RS10720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H74_RS10725	COG0719	Fe-S assembly protein
I6H74_RS10735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H74_RS10755	COG0765	amino acid transport