locus-tag	class	description
I6J14_RS00045	COG1131	(ABC) transporter
I6J14_RS00110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6J14_RS00130	COG1396	sequence-specific DNA binding
I6J14_RS00180	COG1674	ftsk spoiiie
I6J14_RS00230	COG0433	COG0433 Predicted ATPase
I6J14_RS00290	COG0534	Mate efflux family protein
I6J14_RS00310	COG0346	lactoylglutathione lyase activity
I6J14_RS00325	COG3586	endonuclease activity
I6J14_RS00370	COG1518	maintenance of DNA repeat elements
I6J14_RS00375	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6J14_RS00380	COG0673	inositol 2-dehydrogenase activity
I6J14_RS00390	COG0785	Cytochrome C biogenesis protein
I6J14_RS00395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J14_RS00410	COG2972	Histidine kinase
I6J14_RS00435	COG2235	arginine
I6J14_RS00450	COG1288	antiporter activity
I6J14_RS00455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J14_RS00460	COG0549	Belongs to the carbamate kinase family
I6J14_RS00470	COG0742	ribosomal rna small subunit methyltransferase
I6J14_RS00480	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J14_RS00485	COG1609	Transcriptional regulator
I6J14_RS00490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6J14_RS00495	COG1869	D-ribose catabolic process
I6J14_RS00505	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6J14_RS00510	COG1879	ABC-type sugar transport system periplasmic component
I6J14_RS00520	COG5433	transposase activity
I6J14_RS00525	COG4470	Protein conserved in bacteria
I6J14_RS00530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6J14_RS00540	COG1132	(ABC) transporter
I6J14_RS00545	COG1132	(ABC) transporter
I6J14_RS00555	COG0783	Belongs to the Dps family
I6J14_RS00565	COG1940	carbohydrate kinase activity
I6J14_RS00570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J14_RS00575	COG1217	gtp-binding protein TYPA
I6J14_RS00605	COG0849	cell division
I6J14_RS00615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J14_RS00635	COG3599	regulation of cell shape
I6J14_RS00655	COG0542	response to heat
I6J14_RS00660	COG4703	Protein of unknown function (DUF1797)
I6J14_RS00665	COG0765	amino acid transport
I6J14_RS00690	COG0415	Belongs to the DNA photolyase family
I6J14_RS00695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J14_RS00705	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J14_RS00725	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6J14_RS00730	COG1438	arginine binding
I6J14_RS00735	COG0497	DNA recombination
I6J14_RS00750	COG2755	lipolytic protein G-D-S-L family
I6J14_RS00775	COG2217	Heavy metal translocating P-type atpase
I6J14_RS00795	COG1827	regulation of RNA biosynthetic process
I6J14_RS00805	COG2116	formate transmembrane transporter activity
I6J14_RS00810	COG0768	penicillin binding
I6J14_RS00825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J14_RS00860	COG0513	Belongs to the DEAD box helicase family
I6J14_RS00875	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6J14_RS00880	COG0204	Acyl-transferase
I6J14_RS00885	COG1555	photosystem II stabilization
I6J14_RS00885	COG1596	polysaccharide export
I6J14_RS00890	COG0658	competence protein
I6J14_RS00890	COG2333	competence protein COMEC
I6J14_RS00930	COG1187	pseudouridine synthase activity
I6J14_RS00955	COG0431	NADPH-dependent FMN reductase
I6J14_RS00970	COG2223	nitrite transmembrane transporter activity
I6J14_RS00975	COG4122	O-methyltransferase activity
I6J14_RS00990	COG1476	TRANSCRIPTIONal
I6J14_RS01010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J14_RS01015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J14_RS01020	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J14_RS01040	COG0726	polysaccharide deacetylase
I6J14_RS01045	COG0513	Belongs to the DEAD box helicase family
I6J14_RS01065	COG1956	GAF domain-containing protein
I6J14_RS01070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J14_RS01100	COG2211	Major facilitator Superfamily
I6J14_RS01110	COG3250	beta-galactosidase activity
I6J14_RS01115	COG2186	Transcriptional regulator
I6J14_RS01120	COG0800	Aldolase
I6J14_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
I6J14_RS01175	COG4109	DRTGG domain
I6J14_RS01215	COG0789	Transcriptional regulator
I6J14_RS01220	COG1266	CAAX protease self-immunity
I6J14_RS01240	COG4619	ABC transporter
I6J14_RS01245	COG0390	transport system, permease component
I6J14_RS01255	COG2814	Major facilitator Superfamily
I6J14_RS01265	COG1187	pseudouridine synthase activity
I6J14_RS01275	COG2309	aminopeptidase activity
I6J14_RS01310	COG1126	abc transporter atp-binding protein
I6J14_RS01315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J14_RS01320	COG0556	nucleotide-excision repair
I6J14_RS01335	COG1696	Membrane protein involved in D-alanine export
I6J14_RS01345	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6J14_RS01350	COG2182	Extracellular solute-binding protein
I6J14_RS01370	COG3833	ABC-type maltose transport systems, permease component
I6J14_RS01385	COG3833	ABC-type maltose transport systems, permease component
I6J14_RS01395	COG2182	Extracellular solute-binding protein
I6J14_RS01400	COG1609	Transcriptional regulator
I6J14_RS01405	COG1640	4-alpha-glucanotransferase
I6J14_RS01410	COG0058	SHG alpha-glucan phosphorylase activity
I6J14_RS01415	COG0431	NADPH-dependent FMN reductase
I6J14_RS01425	COG1054	Belongs to the UPF0176 family
I6J14_RS01430	COG0572	uridine kinase
I6J14_RS01455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J14_RS01470	COG0300	oxidoreductase activity
I6J14_RS01475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J14_RS01475	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J14_RS01490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J14_RS01495	COG2384	SAM-dependent methyltransferase
I6J14_RS01510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6J14_RS01515	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J14_RS01525	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J14_RS01540	COG1051	belongs to the nudix hydrolase family
I6J14_RS01545	COG0628	permease
I6J14_RS01550	COG0457	Tetratricopeptide repeat
I6J14_RS01555	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6J14_RS01630	COG3942	CHAP domain
I6J14_RS01630	COG1388	LysM domain
I6J14_RS01675	COG3843	relaxase mobilization nuclease domain protein
I6J14_RS01705	COG1122	ATPase activity
I6J14_RS01725	COG0488	(ABC) transporter
I6J14_RS01730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J14_RS01735	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J14_RS01735	COG0022	dehydrogenase e1 component
I6J14_RS01740	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J14_RS01750	COG1695	Transcriptional regulator
I6J14_RS01760	COG0095	Lipoate-protein ligase
I6J14_RS01765	COG3442	glutamine amidotransferase
I6J14_RS01770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J14_RS01775	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J14_RS01795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J14_RS01805	COG0647	UMP catabolic process
I6J14_RS01830	COG1418	mRNA catabolic process
I6J14_RS01860	COG3715	PTS system
I6J14_RS01865	COG3716	PTS system mannose fructose sorbose family IID component
I6J14_RS01870	COG2972	Histidine kinase
I6J14_RS01875	COG2207	Transcriptional regulator
I6J14_RS01875	COG4753	response regulator
I6J14_RS01910	COG1011	Hydrolase
I6J14_RS01915	COG1012	belongs to the aldehyde dehydrogenase family
I6J14_RS01930	COG0561	phosphatase activity
I6J14_RS01950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J14_RS01980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J14_RS02035	COG0765	amino acid transport
I6J14_RS02055	COG0187	DNA topoisomerase II activity
I6J14_RS02070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J14_RS02090	COG0539	negative regulation of cytoplasmic translation
I6J14_RS02110	COG0398	Pfam SNARE associated Golgi protein
I6J14_RS02120	COG1131	(ABC) transporter
I6J14_RS02125	COG1725	Transcriptional regulator
I6J14_RS02140	COG0469	pyruvate kinase activity
I6J14_RS02155	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J14_RS02160	COG0765	amino acid transport
I6J14_RS02165	COG1126	abc transporter atp-binding protein
I6J14_RS02170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J14_RS02180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6J14_RS02185	COG1115	amino acid carrier protein
I6J14_RS02195	COG2261	transglycosylase associated protein
I6J14_RS02235	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6J14_RS02235	COG1136	(ABC) transporter
I6J14_RS02265	COG0196	riboflavin kinase activity
I6J14_RS02280	COG0483	inositol monophosphate 1-phosphatase activity
I6J14_RS02285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J14_RS02285	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6J14_RS02295	COG0573	inorganic phosphate transmembrane transporter activity
I6J14_RS02300	COG0581	inorganic phosphate transmembrane transporter activity
I6J14_RS02315	COG0704	Plays a role in the regulation of phosphate uptake
I6J14_RS02325	COG0745	RESPONSE REGULATOR receiver
I6J14_RS02330	COG5002	protein histidine kinase activity
I6J14_RS02345	COG2813	Specifically methylates the guanine in position
I6J14_RS02350	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6J14_RS02365	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J14_RS02370	COG3845	ABC transporter
I6J14_RS02375	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J14_RS02380	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J14_RS02390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J14_RS02395	COG4684	Psort location CytoplasmicMembrane, score
I6J14_RS02400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J14_RS02410	COG0095	Lipoate-protein ligase
I6J14_RS02460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J14_RS02465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J14_RS02470	COG1328	CTP reductase activity
I6J14_RS02470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J14_RS02475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J14_RS02485	COG0488	(ABC) transporter
I6J14_RS02505	COG1272	protein, Hemolysin III
I6J14_RS02525	COG0758	DNA mediated transformation
I6J14_RS02530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J14_RS02570	COG0511	ligase activity, forming carbon-carbon bonds
I6J14_RS02575	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6J14_RS02595	COG2851	Citrate transporter
I6J14_RS02605	COG0511	ligase activity, forming carbon-carbon bonds
I6J14_RS02610	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6J14_RS02640	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6J14_RS02655	COG1136	(ABC) transporter
I6J14_RS02660	COG0577	efflux transmembrane transporter activity
I6J14_RS02665	COG0745	RESPONSE REGULATOR receiver
I6J14_RS02680	COG1252	NADH dehydrogenase
I6J14_RS02685	COG0142	geranyltranstransferase activity
I6J14_RS02690	COG4939	FMN-binding domain protein
I6J14_RS02720	COG0662	Cupin 2, conserved barrel domain protein
I6J14_RS02725	COG5002	protein histidine kinase activity
I6J14_RS02735	COG1136	(ABC) transporter
I6J14_RS02740	COG0577	efflux transmembrane transporter activity
I6J14_RS02745	COG0673	inositol 2-dehydrogenase activity
I6J14_RS02765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J14_RS02775	COG2188	Transcriptional regulator
I6J14_RS02830	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6J14_RS02835	COG0346	lactoylglutathione lyase activity
I6J14_RS02840	COG3764	Sortase (surface protein transpeptidase)
I6J14_RS02855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J14_RS02865	COG1132	(ABC) transporter
I6J14_RS02870	COG1132	(ABC) transporter
I6J14_RS02895	COG0009	L-threonylcarbamoyladenylate synthase
I6J14_RS02900	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J14_RS02925	COG2233	PERMEase
I6J14_RS02940	COG1174	glycine betaine transport
I6J14_RS02955	COG4221	oxidoreductase activity
I6J14_RS02960	COG0280	phosphate acetyltransferase
I6J14_RS02965	COG0564	pseudouridine synthase activity
I6J14_RS02975	COG2357	RelA SpoT domain protein
I6J14_RS02990	COG1104	cysteine desulfurase activity
I6J14_RS03010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J14_RS03020	COG0628	permease
I6J14_RS03060	COG1177	transmembrane transport
I6J14_RS03065	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J14_RS03095	COG0302	gtp cyclohydrolase
I6J14_RS03100	COG0285	dihydrofolate synthase activity
I6J14_RS03115	COG0726	polysaccharide deacetylase
I6J14_RS03125	COG4974	Belongs to the 'phage' integrase family
I6J14_RS03135	COG1396	sequence-specific DNA binding
I6J14_RS03155	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J14_RS03155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J14_RS03160	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J14_RS03190	COG0347	Belongs to the P(II) protein family
I6J14_RS03195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J14_RS03200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J14_RS03200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J14_RS03200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J14_RS03205	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J14_RS03210	COG1737	Transcriptional regulator
I6J14_RS03225	COG3843	relaxase mobilization nuclease domain protein
I6J14_RS03240	COG4581	dead DEAH box helicase
I6J14_RS03250	COG0542	response to heat
I6J14_RS03255	COG1396	sequence-specific DNA binding
I6J14_RS03400	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6J14_RS03455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J14_RS03465	COG3425	synthase
I6J14_RS03500	COG1132	(ABC) transporter
I6J14_RS03505	COG1132	(ABC) transporter
I6J14_RS03510	COG0737	Belongs to the 5'-nucleotidase family
I6J14_RS03515	COG0242	peptide deformylase activity
I6J14_RS03520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J14_RS03525	COG1132	(ABC) transporter
I6J14_RS03535	COG0488	(ABC) transporter
I6J14_RS03560	COG1388	LysM domain
I6J14_RS03560	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J14_RS03565	COG1388	LysM domain
I6J14_RS03565	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J14_RS03570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J14_RS03570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J14_RS03570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J14_RS03575	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J14_RS03580	COG1349	DNA-binding transcription factor activity
I6J14_RS03615	COG1837	Belongs to the UPF0109 family
I6J14_RS03625	COG0584	glycerophosphoryl diester phosphodiesterase
I6J14_RS03635	COG0577	efflux transmembrane transporter activity
I6J14_RS03640	COG1136	(ABC) transporter
I6J14_RS03645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6J14_RS03680	COG0564	pseudouridine synthase activity
I6J14_RS03690	COG0583	DNA-binding transcription factor activity
I6J14_RS03695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J14_RS03735	COG2801	Transposase and inactivated derivatives
I6J14_RS03760	COG1104	cysteine desulfurase activity
I6J14_RS03775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J14_RS03795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J14_RS03800	COG1368	sulfuric ester hydrolase activity
I6J14_RS03805	COG2801	Transposase and inactivated derivatives
I6J14_RS03855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J14_RS03860	COG1368	sulfuric ester hydrolase activity
I6J14_RS03865	COG0438	transferase activity, transferring glycosyl groups
I6J14_RS03880	COG0463	Glycosyl transferase, family 2
I6J14_RS03905	COG1216	Glycosyl transferase, family 2
I6J14_RS03905	COG1442	glycosyl transferase family 8
I6J14_RS03920	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J14_RS03925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J14_RS03930	COG0358	DNA primase activity
I6J14_RS03935	COG1970	mechanosensitive ion channel activity
I6J14_RS03965	COG2321	neutral zinc metallopeptidase
I6J14_RS03970	COG1136	(ABC) transporter
I6J14_RS03975	COG0577	efflux transmembrane transporter activity
I6J14_RS04075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6J14_RS04080	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6J14_RS04085	COG1523	belongs to the glycosyl hydrolase 13 family
I6J14_RS04090	COG1597	lipid kinase activity
I6J14_RS04100	COG4708	membrane
I6J14_RS04145	COG0560	Phosphoserine phosphatase
I6J14_RS04165	COG0772	Belongs to the SEDS family
I6J14_RS04195	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J14_RS04220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6J14_RS04325	COG5484	DNA packaging
I6J14_RS04470	COG0582	viral genome integration into host DNA
I6J14_RS04480	COG0038	chloride channel
I6J14_RS04490	COG0716	FMN binding
I6J14_RS04505	COG2153	protein acetylation
I6J14_RS04510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J14_RS04520	COG2222	sugar isomerase
I6J14_RS04560	COG0017	Asparaginyl-tRNA synthetase
I6J14_RS04565	COG0436	Aminotransferase
I6J14_RS04570	COG1199	ATP-dependent helicase activity
I6J14_RS04570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J14_RS04580	COG2177	Part of the ABC transporter FtsEX involved in
I6J14_RS04585	COG2884	Cell division ATP-binding protein ftsE
I6J14_RS04595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6J14_RS04600	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6J14_RS04605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J14_RS04630	COG5492	domain, Protein
I6J14_RS04650	COG1028	Short-chain dehydrogenase reductase Sdr
I6J14_RS04665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J14_RS04670	COG3715	PTS system
I6J14_RS04675	COG3716	PTS system mannose fructose sorbose family IID component
I6J14_RS04685	COG1609	Transcriptional regulator
I6J14_RS04705	COG1078	dGTPase activity
I6J14_RS04745	COG1191	sigma factor activity
I6J14_RS04750	COG0772	Belongs to the SEDS family
I6J14_RS04760	COG1164	Oligoendopeptidase f
I6J14_RS04765	COG0386	Belongs to the glutathione peroxidase family
I6J14_RS04790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6J14_RS04815	COG0004	ammonium transporteR
I6J14_RS04830	COG4443	Transcriptional Coactivator p15 (PC4)
I6J14_RS04835	COG0826	peptidase U32
I6J14_RS04880	COG2183	response to ionizing radiation
I6J14_RS04885	COG0704	Plays a role in the regulation of phosphate uptake
I6J14_RS04890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J14_RS04900	COG0573	inorganic phosphate transmembrane transporter activity
I6J14_RS04905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6J14_RS04915	COG0745	RESPONSE REGULATOR receiver
I6J14_RS04930	COG0701	Predicted permease
I6J14_RS04935	COG3689	TIGRFAM TIGR03943 family protein
I6J14_RS04940	COG0552	protein localization to endoplasmic reticulum
I6J14_RS04945	COG0561	phosphatase activity
I6J14_RS04950	COG0561	phosphatase activity
I6J14_RS04970	COG1196	nuclear chromosome segregation
I6J14_RS04980	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J14_RS04985	COG5002	protein histidine kinase activity
I6J14_RS04990	COG0745	RESPONSE REGULATOR receiver
I6J14_RS05000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J14_RS05005	COG0765	amino acid transport
I6J14_RS05010	COG0765	amino acid transport
I6J14_RS05015	COG2801	Transposase and inactivated derivatives
I6J14_RS05030	COG0183	Belongs to the thiolase family
I6J14_RS05040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J14_RS05045	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6J14_RS05050	COG1461	Dihydroxyacetone kinase
I6J14_RS05055	COG2376	Dihydroxyacetone kinase
I6J14_RS05065	COG2376	Dihydroxyacetone kinase
I6J14_RS05080	COG4555	ABC transporter
I6J14_RS05085	COG2801	Transposase and inactivated derivatives
I6J14_RS05095	COG0438	transferase activity, transferring glycosyl groups
I6J14_RS05110	COG1609	Transcriptional regulator
I6J14_RS05115	COG0006	proline dipeptidase activity
I6J14_RS05120	COG0778	Nitroreductase
I6J14_RS05125	COG0346	lactoylglutathione lyase activity
I6J14_RS05135	COG0463	Glycosyl transferase, family 2
I6J14_RS05145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6J14_RS05150	COG0557	exoribonuclease II activity
I6J14_RS05170	COG0433	COG0433 Predicted ATPase
I6J14_RS05180	COG1131	(ABC) transporter
I6J14_RS05195	COG1396	sequence-specific DNA binding
I6J14_RS05260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6J14_RS05270	COG1573	uracil-dna glycosylase
I6J14_RS05275	COG1702	phosphate starvation-inducible protein PhoH
I6J14_RS05480	COG1783	phage Terminase large subunit
I6J14_RS05590	COG3561	AntA/AntB antirepressor
I6J14_RS05635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6J14_RS05660	COG2801	Transposase and inactivated derivatives
I6J14_RS05670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6J14_RS05680	COG0494	nUDIX hydrolase
I6J14_RS05690	COG0673	inositol 2-dehydrogenase activity
I6J14_RS05705	COG1028	Short-chain dehydrogenase reductase Sdr
I6J14_RS05715	COG0582	viral genome integration into host DNA
I6J14_RS05825	COG2801	Transposase and inactivated derivatives
I6J14_RS05830	COG1114	Component of the transport system for branched-chain amino acids
I6J14_RS05875	COG1304	FMN binding
I6J14_RS05880	COG1620	l-lactate permease
I6J14_RS05890	COG0708	Exodeoxyribonuclease III
I6J14_RS05905	COG1393	Belongs to the ArsC family
I6J14_RS05920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6J14_RS05945	COG1774	PSP1 C-terminal conserved region
I6J14_RS05950	COG0470	DNA polymerase III
I6J14_RS05960	COG0517	IMP dehydrogenase activity
I6J14_RS05980	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6J14_RS06015	COG2244	polysaccharide biosynthetic process
I6J14_RS06025	COG1120	ATPase activity
I6J14_RS06030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J14_RS06035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J14_RS06040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J14_RS06055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J14_RS06060	COG1253	flavin adenine dinucleotide binding
I6J14_RS06065	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J14_RS06070	COG1242	4 iron, 4 sulfur cluster binding
I6J14_RS06075	COG0671	phosphoesterase, PA-phosphatase related
I6J14_RS06080	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6J14_RS06095	COG1187	pseudouridine synthase activity
I6J14_RS06115	COG4175	Glycine betaine
I6J14_RS06150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J14_RS06155	COG1254	Belongs to the acylphosphatase family
I6J14_RS06170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J14_RS06190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6J14_RS06200	COG1484	DNA-dependent DNA replication
I6J14_RS06210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J14_RS06215	COG5002	protein histidine kinase activity
I6J14_RS06220	COG0745	RESPONSE REGULATOR receiver
I6J14_RS06230	COG0501	Belongs to the peptidase M48B family
I6J14_RS06235	COG1704	LemA family
I6J14_RS06245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J14_RS06250	COG0569	domain protein
I6J14_RS06260	COG1114	Component of the transport system for branched-chain amino acids
I6J14_RS06275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6J14_RS06280	COG1464	Belongs to the NlpA lipoprotein family
I6J14_RS06290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J14_RS06325	COG0789	Transcriptional regulator
I6J14_RS06330	COG1323	Belongs to the UPF0348 family
I6J14_RS06335	COG2226	methyltransferase
I6J14_RS06340	COG0799	negative regulation of ribosome biogenesis
I6J14_RS06345	COG1335	isochorismatase
I6J14_RS06350	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6J14_RS06360	COG1534	Rna-binding protein
I6J14_RS06365	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J14_RS06370	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6J14_RS06420	COG0444	Belongs to the ABC transporter superfamily
I6J14_RS06425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J14_RS06430	COG0601	transmembrane transport
I6J14_RS06435	COG4166	transmembrane transport
I6J14_RS06440	COG1686	Belongs to the peptidase S11 family
I6J14_RS06450	COG1686	Belongs to the peptidase S11 family
I6J14_RS06465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J14_RS06470	COG0719	Fe-S assembly protein
I6J14_RS06480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J14_RS06500	COG0765	amino acid transport
I6J14_RS06520	COG1266	CAAX protease self-immunity
I6J14_RS06580	COG3279	Response regulator of the LytR AlgR family
I6J14_RS06595	COG3343	RNA polymerase activity
I6J14_RS06605	COG0366	Alpha amylase catalytic
I6J14_RS06615	COG0668	transmembrane transport
I6J14_RS06625	COG4720	Psort location CytoplasmicMembrane, score
I6J14_RS06630	COG0351	phosphomethylpyrimidine kinase
I6J14_RS06640	COG0527	aspartate kinase activity
I6J14_RS06680	COG0561	phosphatase activity
I6J14_RS06700	COG3414	Phosphotransferase system galactitol-specific IIB component
I6J14_RS06705	COG3775	system Galactitol-specific IIC component
I6J14_RS06745	COG0582	viral genome integration into host DNA
I6J14_RS06755	COG3620	sequence-specific DNA binding
I6J14_RS06890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J14_RS06895	COG1476	TRANSCRIPTIONal
I6J14_RS06920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J14_RS06930	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6J14_RS06945	COG1045	serine acetyltransferase
I6J14_RS06960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6J14_RS06965	COG3037	sugar-specific permease SgaT UlaA
I6J14_RS06975	COG3711	transcriptional antiterminator
I6J14_RS07005	COG1846	Transcriptional regulator
I6J14_RS07030	COG4589	Belongs to the CDS family
I6J14_RS07040	COG1862	Preprotein translocase
I6J14_RS07055	COG1523	belongs to the glycosyl hydrolase 13 family
I6J14_RS07065	COG3842	ATPase activity
I6J14_RS07085	COG0737	Belongs to the 5'-nucleotidase family
I6J14_RS07120	COG1363	Peptidase, m42
I6J14_RS07130	COG2190	(PTS) system
I6J14_RS07130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J14_RS07130	COG1263	PTS System
I6J14_RS07135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J14_RS07165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6J14_RS07170	COG0512	Glutamine amidotransferase of anthranilate synthase
I6J14_RS07175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J14_RS07205	COG3732	PTS system glucitol sorbitol-specific
I6J14_RS07210	COG3730	PTS system glucitol sorbitol-specific
I6J14_RS07265	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6J14_RS07285	COG1882	Formate acetyltransferase
I6J14_RS07290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J14_RS07295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J14_RS07300	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J14_RS07305	COG2390	Transcriptional regulator
I6J14_RS07310	COG1349	DNA-binding transcription factor activity
I6J14_RS07315	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J14_RS07320	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J14_RS07405	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J14_RS07410	COG1428	Deoxynucleoside kinase
I6J14_RS07425	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6J14_RS07450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J14_RS07455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J14_RS07465	COG1363	Peptidase, m42
I6J14_RS07470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J14_RS07520	COG4537	Required for transformation and DNA binding
I6J14_RS07525	COG1459	type II secretion system
I6J14_RS07530	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J14_RS07550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J14_RS07550	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6J14_RS07560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J14_RS07565	COG1121	(ABC) transporter
I6J14_RS07615	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6J14_RS07720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6J14_RS07740	COG0201	protein transport
I6J14_RS07745	COG0200	Binds to the 23S rRNA
I6J14_RS07845	COG0051	transcription antitermination factor activity, RNA binding
I6J14_RS07855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6J14_RS07860	COG1064	alcohol dehydrogenase
I6J14_RS07865	COG1063	alcohol dehydrogenase
I6J14_RS07870	COG1454	alcohol dehydrogenase
I6J14_RS07870	COG1012	belongs to the aldehyde dehydrogenase family
I6J14_RS07885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J14_RS07905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J14_RS07915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J14_RS07920	COG0151	Belongs to the GarS family
I6J14_RS07925	COG3942	CHAP domain
I6J14_RS07945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J14_RS07950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J14_RS07960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J14_RS07965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J14_RS07975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J14_RS07995	COG3942	CHAP domain
I6J14_RS08180	COG0531	amino acid
I6J14_RS08190	COG5433	transposase activity
I6J14_RS08195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J14_RS08220	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J14_RS08225	COG2244	polysaccharide biosynthetic process
I6J14_RS08230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J14_RS08240	COG0012	GTP binding
I6J14_RS08255	COG0592	DNA-directed DNA polymerase activity
I6J14_RS08265	COG1475	DNA binding
I6J14_RS08270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J14_RS08300	COG0488	(ABC) transporter
I6J14_RS08305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J14_RS08325	COG2801	Transposase and inactivated derivatives
I6J14_RS08330	COG0516	GMP reductase activity
I6J14_RS08330	COG0517	IMP dehydrogenase activity
I6J14_RS08355	COG0612	Peptidase, M16
I6J14_RS08365	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J14_RS08385	COG0741	lytic transglycosylase activity
I6J14_RS08395	COG1760	l-serine dehydratase
I6J14_RS08400	COG1760	l-serine dehydratase
I6J14_RS08410	COG2095	MarC family integral membrane protein
I6J14_RS08435	COG0305	Participates in initiation and elongation during chromosome replication
I6J14_RS08445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6J14_RS08455	COG1511	domain protein
I6J14_RS08510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J14_RS08515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J14_RS08520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J14_RS08525	COG0488	(ABC) transporter
I6J14_RS08570	COG0519	Catalyzes the synthesis of GMP from XMP
I6J14_RS08590	COG1393	Belongs to the ArsC family
I6J14_RS08595	COG4472	Bacterial protein of unknown function (DUF965)
I6J14_RS08635	COG0602	queuosine metabolic process
I6J14_RS08645	COG2514	catechol 2,3-dioxygenase activity
I6J14_RS08650	COG1733	regulation of RNA biosynthetic process
I6J14_RS08655	COG2188	Transcriptional regulator
I6J14_RS08660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J14_RS08660	COG1263	PTS System
I6J14_RS08665	COG0366	Alpha amylase catalytic
I6J14_RS08670	COG3590	peptidase
I6J14_RS08700	COG0531	amino acid
I6J14_RS08715	COG3404	Formiminotransferase-cyclodeaminase
I6J14_RS08725	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6J14_RS08740	COG0450	alkyl hydroperoxide reductase
I6J14_RS08820	COG4463	regulation of RNA biosynthetic process
I6J14_RS08825	COG0542	response to heat
I6J14_RS08840	COG1051	belongs to the nudix hydrolase family
I6J14_RS08855	COG0564	pseudouridine synthase activity
I6J14_RS08870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J14_RS08910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J14_RS08920	COG3623	hexulose-6-phosphate isomerase
I6J14_RS08940	COG1597	lipid kinase activity
I6J14_RS08945	COG3448	diguanylate cyclase activity
I6J14_RS08945	COG4175	Glycine betaine
I6J14_RS08955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J14_RS08955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J14_RS08960	COG1832	CoA-binding protein
I6J14_RS08985	COG1268	BioY protein
I6J14_RS08990	COG1234	tRNA 3'-trailer cleavage
I6J14_RS09035	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J14_RS09040	COG0457	Tetratricopeptide repeat
I6J14_RS09040	COG0705	Rhomboid family
I6J14_RS09045	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J14_RS09060	COG1132	(ABC) transporter
I6J14_RS09065	COG1132	(ABC) transporter
I6J14_RS09075	COG0756	dUTP diphosphatase activity
I6J14_RS09135	COG1847	R3H domain protein
I6J14_RS09155	COG1175	transmembrane transport
I6J14_RS09160	COG0395	ABC-type sugar transport system, permease component
I6J14_RS09175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J14_RS09200	COG0084	hydrolase, TatD family'
I6J14_RS09230	COG1564	THIamine pyrophosphokinase
I6J14_RS09245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J14_RS09275	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6J14_RS09285	COG0126	phosphoglycerate kinase activity
I6J14_RS09295	COG0789	Transcriptional regulator
I6J14_RS09300	COG0174	glutamine synthetase
I6J14_RS09305	COG4166	transmembrane transport
I6J14_RS09310	COG0601	transmembrane transport
I6J14_RS09315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J14_RS09320	COG0444	Belongs to the ABC transporter superfamily
I6J14_RS09325	COG4608	Belongs to the ABC transporter superfamily
I6J14_RS09335	COG5503	Protein of unknown function (DUF1447)
I6J14_RS09340	COG1214	PFAM Peptidase M22, glycoprotease
I6J14_RS09360	COG2081	HI0933 family
I6J14_RS09375	COG0789	Transcriptional regulator
I6J14_RS09400	COG5002	protein histidine kinase activity
I6J14_RS09430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J14_RS09450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J14_RS09465	COG1882	Formate acetyltransferase
I6J14_RS09480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J14_RS09485	COG0681	Belongs to the peptidase S26 family
I6J14_RS09510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J14_RS09515	COG3118	belongs to the thioredoxin family
I6J14_RS09525	COG1194	a g-specific adenine glycosylase
I6J14_RS09575	COG0006	proline dipeptidase activity
I6J14_RS09580	COG2131	deaminase
I6J14_RS09600	COG1609	Transcriptional regulator
I6J14_RS09605	COG1621	beta-fructofuranosidase activity
I6J14_RS09610	COG1263	PTS System
I6J14_RS09610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J14_RS09610	COG2190	(PTS) system
I6J14_RS09620	COG1482	cell wall glycoprotein biosynthetic process
I6J14_RS09640	COG1388	LysM domain
I6J14_RS09640	COG3942	CHAP domain
I6J14_RS09665	COG1120	ATPase activity
I6J14_RS09670	COG4988	ABC transporter
I6J14_RS09675	COG1132	(ABC) transporter
I6J14_RS09690	COG1129	ABC transporter
I6J14_RS09695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J14_RS09700	COG4989	oxidoreductase activity
I6J14_RS09705	COG0252	asparaginase activity
I6J14_RS09715	COG0561	phosphatase activity
I6J14_RS09725	COG0436	Aminotransferase
I6J14_RS09735	COG1335	isochorismatase
I6J14_RS09740	COG1937	Protein conserved in bacteria
I6J14_RS09750	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J14_RS09760	COG0517	IMP dehydrogenase activity
I6J14_RS09765	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6J14_RS09770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6J14_RS09770	COG0574	Belongs to the PEP-utilizing enzyme family
I6J14_RS09790	COG0697	spore germination
I6J14_RS09795	COG2261	transglycosylase associated protein
I6J14_RS09800	COG0588	phosphoglycerate mutase activity
I6J14_RS09815	COG1420	regulation of RNA biosynthetic process
I6J14_RS09835	COG0484	heat shock protein binding
I6J14_RS09840	COG1024	Enoyl-CoA hydratase
I6J14_RS09860	COG2070	2-Nitropropane dioxygenase
I6J14_RS09865	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J14_RS09870	COG1028	Short-chain dehydrogenase reductase Sdr
I6J14_RS09875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J14_RS09890	COG0439	Biotin carboxylase
I6J14_RS09920	COG3716	PTS system mannose fructose sorbose family IID component
I6J14_RS09925	COG3715	PTS system
I6J14_RS09935	COG0561	phosphatase activity
I6J14_RS09940	COG2252	PERMEase
I6J14_RS09945	COG0802	atpase or kinase
I6J14_RS09950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J14_RS09955	COG1316	TRANSCRIPTIONal
I6J14_RS09965	COG0537	adenosine 5'-monophosphoramidase activity
I6J14_RS09970	COG1131	(ABC) transporter
I6J14_RS09975	COG4473	ABC transporter
I6J14_RS10005	COG0195	Participates in both transcription termination and antitermination
I6J14_RS10010	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6J14_RS10040	COG2217	Heavy metal translocating P-type atpase
I6J14_RS10090	COG2860	membrane
I6J14_RS10095	COG0561	phosphatase activity
I6J14_RS10115	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J14_RS10125	COG0656	L-ascorbic acid biosynthetic process
I6J14_RS10130	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6J14_RS10165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6J14_RS10170	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6J14_RS10195	COG1131	(ABC) transporter
I6J14_RS10230	COG0768	penicillin binding
I6J14_RS10240	COG0513	Belongs to the DEAD box helicase family
I6J14_RS10250	COG0765	amino acid transport
I6J14_RS10255	COG1126	abc transporter atp-binding protein
I6J14_RS10265	COG0492	ferredoxin-NADP+ reductase activity
I6J14_RS10270	COG1113	amino acid transport
I6J14_RS10275	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J14_RS10285	COG3579	cysteine-type endopeptidase activity
I6J14_RS10290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J14_RS10315	COG0116	Belongs to the methyltransferase superfamily
I6J14_RS10330	COG2610	gluconate transmembrane transporter activity
I6J14_RS10335	COG1028	Short-chain dehydrogenase reductase Sdr
I6J14_RS10345	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6J14_RS10350	COG0183	Belongs to the thiolase family
I6J14_RS10355	COG0583	DNA-binding transcription factor activity
I6J14_RS10375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J14_RS10385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J14_RS10385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J14_RS10395	COG0515	serine threonine protein kinase
I6J14_RS10395	COG2815	serine threonine protein kinase
I6J14_RS10405	COG4585	Histidine kinase
I6J14_RS10410	COG2197	response regulator
I6J14_RS10420	COG1098	S1 RNA binding domain
I6J14_RS10430	COG1739	Uncharacterized protein family UPF0029
I6J14_RS10435	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6J14_RS10440	COG1040	competence protein
I6J14_RS10460	COG3620	sequence-specific DNA binding
I6J14_RS10465	COG1131	(ABC) transporter
I6J14_RS10470	COG1137	ATPase activity
I6J14_RS10495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J14_RS10500	COG0601	transmembrane transport
I6J14_RS10600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6J14_RS10625	COG2186	Transcriptional regulator
I6J14_RS10630	COG2723	6-phospho-beta-galactosidase activity
I6J14_RS10665	COG1605	Chorismate mutase
I6J14_RS10665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J14_RS10675	COG0803	Belongs to the bacterial solute-binding protein 9 family