locus-tag	class	description
H7680_RS00010	COG0592	DNA-directed DNA polymerase activity
H7680_RS00025	COG0012	GTP binding
H7680_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7680_RS00040	COG2244	polysaccharide biosynthetic process
H7680_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H7680_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7680_RS00075	COG0531	amino acid
H7680_RS00260	COG3942	CHAP domain
H7680_RS00280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7680_RS00285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7680_RS00290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7680_RS00300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7680_RS00305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7680_RS00320	COG3942	CHAP domain
H7680_RS00325	COG0151	Belongs to the GarS family
H7680_RS00330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7680_RS00350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7680_RS00365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7680_RS00380	COG1454	alcohol dehydrogenase
H7680_RS00380	COG1012	belongs to the aldehyde dehydrogenase family
H7680_RS00385	COG1064	alcohol dehydrogenase
H7680_RS00390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7680_RS00410	COG0051	transcription antitermination factor activity, RNA binding
H7680_RS00510	COG0200	Binds to the 23S rRNA
H7680_RS00515	COG0201	protein transport
H7680_RS00535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7680_RS00645	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H7680_RS00655	COG1252	NADH dehydrogenase
H7680_RS00660	COG1271	oxidase subunit
H7680_RS00665	COG1294	oxidase, subunit
H7680_RS00670	COG4988	ABC transporter
H7680_RS00675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7680_RS00680	COG0142	geranyltranstransferase activity
H7680_RS00695	COG1121	(ABC) transporter
H7680_RS00700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7680_RS00710	COG4499	WXG100 protein secretion system (Wss), protein YukC
H7680_RS00710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7680_RS00730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7680_RS00735	COG1459	type II secretion system
H7680_RS00740	COG4537	Required for transformation and DNA binding
H7680_RS00780	COG1266	CAAX protease self-immunity
H7680_RS00790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7680_RS00795	COG1363	Peptidase, m42
H7680_RS00805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7680_RS00810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7680_RS00820	COG1428	Deoxynucleoside kinase
H7680_RS00825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7680_RS00885	COG0251	oxidation-reduction process
H7680_RS00910	COG1744	ABC transporter substrate-binding protein PnrA-like
H7680_RS00915	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7680_RS00920	COG1349	DNA-binding transcription factor activity
H7680_RS00925	COG2390	Transcriptional regulator
H7680_RS00930	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7680_RS00935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7680_RS00940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7680_RS00945	COG1882	Formate acetyltransferase
H7680_RS00960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7680_RS00985	COG3655	Transcriptional regulator
H7680_RS01000	COG0488	(ABC) transporter
H7680_RS01050	COG1132	(ABC) transporter
H7680_RS01085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7680_RS01090	COG0512	Glutamine amidotransferase of anthranilate synthase
H7680_RS01095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7680_RS01110	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7680_RS01115	COG1609	Transcriptional regulator
H7680_RS01120	COG1263	PTS System
H7680_RS01120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7680_RS01120	COG2190	(PTS) system
H7680_RS01135	COG1363	Peptidase, m42
H7680_RS01185	COG3842	ATPase activity
H7680_RS01195	COG1523	belongs to the glycosyl hydrolase 13 family
H7680_RS01210	COG1862	Preprotein translocase
H7680_RS01220	COG4589	Belongs to the CDS family
H7680_RS01245	COG1846	Transcriptional regulator
H7680_RS01280	COG1126	abc transporter atp-binding protein
H7680_RS01290	COG3711	transcriptional antiterminator
H7680_RS01305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7680_RS01320	COG1045	serine acetyltransferase
H7680_RS01335	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H7680_RS01355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7680_RS01375	COG1476	TRANSCRIPTIONal
H7680_RS01385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7680_RS01435	COG2274	protein secretion by the type I secretion system
H7680_RS01440	COG1136	(ABC) transporter
H7680_RS01445	COG0577	efflux transmembrane transporter activity
H7680_RS01490	COG3775	system Galactitol-specific IIC component
H7680_RS01495	COG3414	Phosphotransferase system galactitol-specific IIB component
H7680_RS01515	COG0561	phosphatase activity
H7680_RS01560	COG0527	aspartate kinase activity
H7680_RS01570	COG0351	phosphomethylpyrimidine kinase
H7680_RS01575	COG4720	Psort location CytoplasmicMembrane, score
H7680_RS01585	COG0668	transmembrane transport
H7680_RS01590	COG0366	Alpha amylase catalytic
H7680_RS01595	COG0366	Alpha amylase catalytic
H7680_RS01605	COG3343	RNA polymerase activity
H7680_RS01620	COG3279	Response regulator of the LytR AlgR family
H7680_RS01630	COG1346	cytolysis
H7680_RS01680	COG0765	amino acid transport
H7680_RS01700	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7680_RS01710	COG0719	Fe-S assembly protein
H7680_RS01715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7680_RS01730	COG1686	Belongs to the peptidase S11 family
H7680_RS01735	COG1686	Belongs to the peptidase S11 family
H7680_RS01740	COG4166	transmembrane transport
H7680_RS01745	COG0601	transmembrane transport
H7680_RS01750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7680_RS01755	COG0444	Belongs to the ABC transporter superfamily
H7680_RS01810	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H7680_RS01815	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7680_RS01820	COG1534	Rna-binding protein
H7680_RS01830	COG1713	HD superfamily hydrolase involved in NAD metabolism
H7680_RS01840	COG0799	negative regulation of ribosome biogenesis
H7680_RS01845	COG2226	methyltransferase
H7680_RS01855	COG0789	Transcriptional regulator
H7680_RS01890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7680_RS01900	COG1464	Belongs to the NlpA lipoprotein family
H7680_RS01920	COG1114	Component of the transport system for branched-chain amino acids
H7680_RS01930	COG0569	domain protein
H7680_RS01935	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7680_RS01945	COG1704	LemA family
H7680_RS01960	COG0745	RESPONSE REGULATOR receiver
H7680_RS01965	COG5002	protein histidine kinase activity
H7680_RS01970	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7680_RS01980	COG1484	DNA-dependent DNA replication
H7680_RS01990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7680_RS02010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7680_RS02025	COG1254	Belongs to the acylphosphatase family
H7680_RS02030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7680_RS02065	COG4175	Glycine betaine
H7680_RS02085	COG1187	pseudouridine synthase activity
H7680_RS02100	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H7680_RS02105	COG0671	phosphoesterase, PA-phosphatase related
H7680_RS02110	COG1242	4 iron, 4 sulfur cluster binding
H7680_RS02115	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H7680_RS02120	COG1253	flavin adenine dinucleotide binding
H7680_RS02125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7680_RS02140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7680_RS02145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7680_RS02150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7680_RS02155	COG1120	ATPase activity
H7680_RS02165	COG2244	polysaccharide biosynthetic process
H7680_RS02205	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7680_RS02215	COG0411	ABC transporter
H7680_RS02225	COG0517	IMP dehydrogenase activity
H7680_RS02235	COG0470	DNA polymerase III
H7680_RS02240	COG1774	PSP1 C-terminal conserved region
H7680_RS02265	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7680_RS02280	COG1393	Belongs to the ArsC family
H7680_RS02295	COG1609	Transcriptional regulator
H7680_RS02300	COG0561	phosphatase activity
H7680_RS02305	COG0708	Exodeoxyribonuclease III
H7680_RS02315	COG1620	l-lactate permease
H7680_RS02320	COG1304	FMN binding
H7680_RS02360	COG1114	Component of the transport system for branched-chain amino acids
H7680_RS02375	COG1028	Short-chain dehydrogenase reductase Sdr
H7680_RS02390	COG0673	inositol 2-dehydrogenase activity
H7680_RS02415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7680_RS02440	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7680_RS02505	COG1702	phosphate starvation-inducible protein PhoH
H7680_RS02510	COG1573	uracil-dna glycosylase
H7680_RS02520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7680_RS02570	COG3279	Response regulator of the LytR AlgR family
H7680_RS02590	COG2274	protein secretion by the type I secretion system
H7680_RS02655	COG1396	sequence-specific DNA binding
H7680_RS02670	COG1131	(ABC) transporter
H7680_RS02680	COG0433	COG0433 Predicted ATPase
H7680_RS02685	COG2814	Major facilitator Superfamily
H7680_RS02700	COG0557	exoribonuclease II activity
H7680_RS02705	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7680_RS02715	COG0463	Glycosyl transferase, family 2
H7680_RS02725	COG0346	lactoylglutathione lyase activity
H7680_RS02730	COG0778	Nitroreductase
H7680_RS02735	COG0006	proline dipeptidase activity
H7680_RS02740	COG1609	Transcriptional regulator
H7680_RS02755	COG0438	transferase activity, transferring glycosyl groups
H7680_RS02765	COG4555	ABC transporter
H7680_RS02780	COG2376	Dihydroxyacetone kinase
H7680_RS02790	COG2376	Dihydroxyacetone kinase
H7680_RS02795	COG1461	Dihydroxyacetone kinase
H7680_RS02800	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H7680_RS02805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7680_RS02830	COG0765	amino acid transport
H7680_RS02835	COG0765	amino acid transport
H7680_RS02840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7680_RS02850	COG0745	RESPONSE REGULATOR receiver
H7680_RS02855	COG5002	protein histidine kinase activity
H7680_RS02860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7680_RS02870	COG1196	nuclear chromosome segregation
H7680_RS02890	COG0561	phosphatase activity
H7680_RS02895	COG0561	phosphatase activity
H7680_RS02900	COG0552	protein localization to endoplasmic reticulum
H7680_RS02905	COG0477	Major facilitator Superfamily
H7680_RS02910	COG3711	transcriptional antiterminator
H7680_RS02915	COG2190	(PTS) system
H7680_RS02915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7680_RS02915	COG1263	PTS System
H7680_RS02925	COG3689	TIGRFAM TIGR03943 family protein
H7680_RS02930	COG0701	Predicted permease
H7680_RS02950	COG0745	RESPONSE REGULATOR receiver
H7680_RS02955	COG5002	protein histidine kinase activity
H7680_RS02960	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7680_RS02965	COG0573	inorganic phosphate transmembrane transporter activity
H7680_RS02975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7680_RS02980	COG0704	Plays a role in the regulation of phosphate uptake
H7680_RS02995	COG2183	response to ionizing radiation
H7680_RS03040	COG0826	peptidase U32
H7680_RS03045	COG4443	Transcriptional Coactivator p15 (PC4)
H7680_RS03060	COG0004	ammonium transporteR
H7680_RS03065	COG0582	viral genome integration into host DNA
H7680_RS03075	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7680_RS03075	COG3942	CHAP domain
H7680_RS03095	COG0433	COG0433 Predicted ATPase
H7680_RS03145	COG1674	ftsk spoiiie
H7680_RS03165	COG3620	sequence-specific DNA binding
H7680_RS03185	COG3620	sequence-specific DNA binding
H7680_RS03190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7680_RS03240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7680_RS03270	COG0386	Belongs to the glutathione peroxidase family
H7680_RS03275	COG1164	Oligoendopeptidase f
H7680_RS03285	COG0772	Belongs to the SEDS family
H7680_RS03290	COG1191	sigma factor activity
H7680_RS03360	COG1078	dGTPase activity
H7680_RS03380	COG1609	Transcriptional regulator
H7680_RS03390	COG3716	PTS system mannose fructose sorbose family IID component
H7680_RS03395	COG3715	PTS system
H7680_RS03400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7680_RS03415	COG1028	Short-chain dehydrogenase reductase Sdr
H7680_RS03435	COG5492	domain, Protein
H7680_RS03455	COG1396	sequence-specific DNA binding
H7680_RS03460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H7680_RS03465	COG0542	response to heat
H7680_RS03470	COG0542	response to heat
H7680_RS03485	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7680_RS03490	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H7680_RS03495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7680_RS03505	COG2884	Cell division ATP-binding protein ftsE
H7680_RS03510	COG2177	Part of the ABC transporter FtsEX involved in
H7680_RS03520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7680_RS03520	COG1199	ATP-dependent helicase activity
H7680_RS03525	COG0436	Aminotransferase
H7680_RS03530	COG0017	Asparaginyl-tRNA synthetase
H7680_RS03565	COG2188	Transcriptional regulator
H7680_RS03570	COG2222	sugar isomerase
H7680_RS03595	COG3715	PTS system
H7680_RS03600	COG3716	PTS system mannose fructose sorbose family IID component
H7680_RS03620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7680_RS03625	COG2153	protein acetylation
H7680_RS03630	COG0625	glutathione transferase activity
H7680_RS03640	COG0716	FMN binding
H7680_RS03650	COG0038	chloride channel
H7680_RS03665	COG0772	Belongs to the SEDS family
H7680_RS03685	COG0560	Phosphoserine phosphatase
H7680_RS03730	COG1131	(ABC) transporter
H7680_RS03750	COG4708	membrane
H7680_RS03760	COG1597	lipid kinase activity
H7680_RS03765	COG1523	belongs to the glycosyl hydrolase 13 family
H7680_RS03770	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7680_RS03775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7680_RS03780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7680_RS03870	COG0577	efflux transmembrane transporter activity
H7680_RS03875	COG1136	(ABC) transporter
H7680_RS03880	COG2321	neutral zinc metallopeptidase
H7680_RS03895	COG0436	Aminotransferase
H7680_RS03910	COG1970	mechanosensitive ion channel activity
H7680_RS03915	COG0358	DNA primase activity
H7680_RS03920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7680_RS03925	COG2151	metal-sulfur cluster biosynthetic enzyme
H7680_RS03940	COG1442	glycosyl transferase family 8
H7680_RS03940	COG1216	Glycosyl transferase, family 2
H7680_RS03980	COG0463	Glycosyl transferase, family 2
H7680_RS03995	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7680_RS04045	COG1368	sulfuric ester hydrolase activity
H7680_RS04050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7680_RS04070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7680_RS04075	COG0285	dihydrofolate synthase activity
H7680_RS04085	COG1104	cysteine desulfurase activity
H7680_RS04115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7680_RS04120	COG0583	DNA-binding transcription factor activity
H7680_RS04130	COG0564	pseudouridine synthase activity
H7680_RS04165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7680_RS04170	COG1136	(ABC) transporter
H7680_RS04175	COG0577	efflux transmembrane transporter activity
H7680_RS04185	COG0584	glycerophosphoryl diester phosphodiesterase
H7680_RS04195	COG1837	Belongs to the UPF0109 family
H7680_RS04245	COG1349	DNA-binding transcription factor activity
H7680_RS04250	COG1105	Belongs to the carbohydrate kinase PfkB family
H7680_RS04255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7680_RS04255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7680_RS04255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7680_RS04260	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7680_RS04260	COG1388	LysM domain
H7680_RS04265	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7680_RS04265	COG1388	LysM domain
H7680_RS04290	COG0488	(ABC) transporter
H7680_RS04300	COG1132	(ABC) transporter
H7680_RS04305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7680_RS04310	COG0242	peptide deformylase activity
H7680_RS04315	COG0737	Belongs to the 5'-nucleotidase family
H7680_RS04320	COG2357	RelA SpoT domain protein
H7680_RS04325	COG0745	RESPONSE REGULATOR receiver
H7680_RS04380	COG3425	synthase
H7680_RS04390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7680_RS04460	COG1349	DNA-binding transcription factor activity
H7680_RS04470	COG0698	ribose 5-phosphate isomerase
H7680_RS04475	COG1105	Belongs to the carbohydrate kinase PfkB family
H7680_RS04480	COG3684	Belongs to the aldolase LacD family
H7680_RS04485	COG3711	transcriptional antiterminator
H7680_RS04490	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7680_RS04495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7680_RS04495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7680_RS04500	COG2723	6-phospho-beta-galactosidase activity
H7680_RS04515	COG1396	sequence-specific DNA binding
H7680_RS04530	COG1686	Belongs to the peptidase S11 family
H7680_RS04535	COG0726	polysaccharide deacetylase
H7680_RS04550	COG0285	dihydrofolate synthase activity
H7680_RS04555	COG0302	gtp cyclohydrolase
H7680_RS04585	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7680_RS04590	COG1177	transmembrane transport
H7680_RS04600	COG4565	transcriptional regulatory protein
H7680_RS04605	COG3290	protein histidine kinase activity
H7680_RS04610	COG3493	citrate carrier protein
H7680_RS04620	COG0038	chloride channel
H7680_RS04625	COG4977	sequence-specific DNA binding
H7680_RS04625	COG1917	Cupin 2, conserved barrel domain protein
H7680_RS04635	COG0628	permease
H7680_RS04645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7680_RS04665	COG1104	cysteine desulfurase activity
H7680_RS04680	COG2357	RelA SpoT domain protein
H7680_RS04690	COG0564	pseudouridine synthase activity
H7680_RS04695	COG0280	phosphate acetyltransferase
H7680_RS04700	COG4221	oxidoreductase activity
H7680_RS04715	COG1174	glycine betaine transport
H7680_RS04730	COG2233	PERMEase
H7680_RS04755	COG2890	protein-(glutamine-N5) methyltransferase activity
H7680_RS04760	COG0009	L-threonylcarbamoyladenylate synthase
H7680_RS04785	COG1132	(ABC) transporter
H7680_RS04790	COG1132	(ABC) transporter
H7680_RS04800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7680_RS04815	COG3764	Sortase (surface protein transpeptidase)
H7680_RS04820	COG0346	lactoylglutathione lyase activity
H7680_RS04860	COG1136	(ABC) transporter
H7680_RS04865	COG0577	efflux transmembrane transporter activity
H7680_RS04870	COG0745	RESPONSE REGULATOR receiver
H7680_RS04875	COG2205	protein histidine kinase activity
H7680_RS04880	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7680_RS04880	COG3942	CHAP domain
H7680_RS04905	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7680_RS04925	COG1122	ATPase activity
H7680_RS04935	COG0601	transmembrane transport
H7680_RS04980	COG2188	Transcriptional regulator
H7680_RS04990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7680_RS05010	COG0673	inositol 2-dehydrogenase activity
H7680_RS05020	COG5002	protein histidine kinase activity
H7680_RS05025	COG0662	Cupin 2, conserved barrel domain protein
H7680_RS05055	COG4939	FMN-binding domain protein
H7680_RS05060	COG0142	geranyltranstransferase activity
H7680_RS05065	COG1252	NADH dehydrogenase
H7680_RS05075	COG5002	protein histidine kinase activity
H7680_RS05080	COG0745	RESPONSE REGULATOR receiver
H7680_RS05085	COG0577	efflux transmembrane transporter activity
H7680_RS05090	COG1136	(ABC) transporter
H7680_RS05105	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
H7680_RS05140	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H7680_RS05145	COG0511	ligase activity, forming carbon-carbon bonds
H7680_RS05155	COG2851	Citrate transporter
H7680_RS05175	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
H7680_RS05180	COG0511	ligase activity, forming carbon-carbon bonds
H7680_RS05230	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7680_RS05235	COG0758	DNA mediated transformation
H7680_RS05270	COG1396	sequence-specific DNA binding
H7680_RS05280	COG1272	protein, Hemolysin III
H7680_RS05300	COG0488	(ABC) transporter
H7680_RS05320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7680_RS05325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7680_RS05325	COG1328	CTP reductase activity
H7680_RS05330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7680_RS05335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7680_RS05390	COG0095	Lipoate-protein ligase
H7680_RS05400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7680_RS05405	COG4684	Psort location CytoplasmicMembrane, score
H7680_RS05410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7680_RS05415	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7680_RS05420	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7680_RS05425	COG3845	ABC transporter
H7680_RS05430	COG1744	ABC transporter substrate-binding protein PnrA-like
H7680_RS05445	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7680_RS05450	COG2813	Specifically methylates the guanine in position
H7680_RS05465	COG5002	protein histidine kinase activity
H7680_RS05470	COG0745	RESPONSE REGULATOR receiver
H7680_RS05480	COG0704	Plays a role in the regulation of phosphate uptake
H7680_RS05495	COG0581	inorganic phosphate transmembrane transporter activity
H7680_RS05500	COG0573	inorganic phosphate transmembrane transporter activity
H7680_RS05510	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H7680_RS05510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7680_RS05515	COG0483	inositol monophosphate 1-phosphatase activity
H7680_RS05530	COG0196	riboflavin kinase activity
H7680_RS05560	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7680_RS05560	COG1136	(ABC) transporter
H7680_RS05600	COG2261	transglycosylase associated protein
H7680_RS05610	COG1115	amino acid carrier protein
H7680_RS05615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7680_RS05625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7680_RS05630	COG1126	abc transporter atp-binding protein
H7680_RS05635	COG0765	amino acid transport
H7680_RS05640	COG2824	Alkylphosphonate utilization operon protein PhnA
H7680_RS05655	COG0469	pyruvate kinase activity
H7680_RS05670	COG1725	Transcriptional regulator
H7680_RS05675	COG1131	(ABC) transporter
H7680_RS05685	COG0398	Pfam SNARE associated Golgi protein
H7680_RS05710	COG0539	negative regulation of cytoplasmic translation
H7680_RS05730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7680_RS05745	COG0187	DNA topoisomerase II activity
H7680_RS05765	COG0765	amino acid transport
H7680_RS05780	COG2801	Transposase and inactivated derivatives
H7680_RS05820	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7680_RS05850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7680_RS05860	COG0028	Belongs to the TPP enzyme family
H7680_RS05885	COG1012	belongs to the aldehyde dehydrogenase family
H7680_RS05890	COG1011	Hydrolase
H7680_RS05905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7680_RS05925	COG2972	Histidine kinase
H7680_RS05930	COG3716	PTS system mannose fructose sorbose family IID component
H7680_RS05935	COG3715	PTS system
H7680_RS05995	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H7680_RS06000	COG1518	maintenance of DNA repeat elements
H7680_RS06015	COG0647	UMP catabolic process
H7680_RS06025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7680_RS06045	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H7680_RS06050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7680_RS06055	COG3442	glutamine amidotransferase
H7680_RS06060	COG0095	Lipoate-protein ligase
H7680_RS06070	COG1695	Transcriptional regulator
H7680_RS06080	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7680_RS06085	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7680_RS06085	COG0022	dehydrogenase e1 component
H7680_RS06090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7680_RS06095	COG0488	(ABC) transporter
H7680_RS06115	COG1122	ATPase activity
H7680_RS06145	COG3700	Belongs to the class B bacterial acid phosphatase family
H7680_RS06165	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H7680_RS06170	COG0457	Tetratricopeptide repeat
H7680_RS06175	COG0628	permease
H7680_RS06180	COG1051	belongs to the nudix hydrolase family
H7680_RS06195	COG1088	dTDP-glucose 4,6-dehydratase activity
H7680_RS06205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7680_RS06210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7680_RS06225	COG2384	SAM-dependent methyltransferase
H7680_RS06230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7680_RS06245	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7680_RS06245	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H7680_RS06250	COG0300	oxidoreductase activity
H7680_RS06265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7680_RS06290	COG0572	uridine kinase
H7680_RS06295	COG1054	Belongs to the UPF0176 family
H7680_RS06305	COG0431	NADPH-dependent FMN reductase
H7680_RS06310	COG0058	SHG alpha-glucan phosphorylase activity
H7680_RS06315	COG1640	4-alpha-glucanotransferase
H7680_RS06320	COG1609	Transcriptional regulator
H7680_RS06330	COG2182	Extracellular solute-binding protein
H7680_RS06340	COG3833	ABC-type maltose transport systems, permease component
H7680_RS06355	COG3833	ABC-type maltose transport systems, permease component
H7680_RS06365	COG0366	Alpha amylase catalytic
H7680_RS06370	COG2182	Extracellular solute-binding protein
H7680_RS06375	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H7680_RS06385	COG1696	Membrane protein involved in D-alanine export
H7680_RS06405	COG0765	amino acid transport
H7680_RS06410	COG1126	abc transporter atp-binding protein
H7680_RS06420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7680_RS06430	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7680_RS06440	COG3711	transcriptional antiterminator
H7680_RS06440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7680_RS06450	COG2723	6-phospho-beta-galactosidase activity
H7680_RS06475	COG2309	aminopeptidase activity
H7680_RS06485	COG1187	pseudouridine synthase activity
H7680_RS06495	COG2814	Major facilitator Superfamily
H7680_RS06505	COG0390	transport system, permease component
H7680_RS06510	COG4619	ABC transporter
H7680_RS06525	COG1464	Belongs to the NlpA lipoprotein family
H7680_RS06590	COG4109	DRTGG domain
H7680_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
H7680_RS06630	COG0800	Aldolase
H7680_RS06635	COG2186	Transcriptional regulator
H7680_RS06640	COG3250	beta-galactosidase activity
H7680_RS06650	COG2211	Major facilitator Superfamily
H7680_RS06670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H7680_RS06670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H7680_RS06680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7680_RS06685	COG1956	GAF domain-containing protein
H7680_RS06705	COG0513	Belongs to the DEAD box helicase family
H7680_RS06710	COG0726	polysaccharide deacetylase
H7680_RS06730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7680_RS06735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7680_RS06740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7680_RS06760	COG1476	TRANSCRIPTIONal
H7680_RS06785	COG4122	O-methyltransferase activity
H7680_RS06790	COG2223	nitrite transmembrane transporter activity
H7680_RS06805	COG0431	NADPH-dependent FMN reductase
H7680_RS06825	COG1187	pseudouridine synthase activity
H7680_RS06860	COG0658	competence protein
H7680_RS06860	COG2333	competence protein COMEC
H7680_RS06865	COG1596	polysaccharide export
H7680_RS06865	COG1555	photosystem II stabilization
H7680_RS06870	COG0204	Acyl-transferase
H7680_RS06875	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7680_RS06890	COG0513	Belongs to the DEAD box helicase family
H7680_RS06895	COG1464	Belongs to the NlpA lipoprotein family
H7680_RS06905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7680_RS06925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7680_RS06940	COG0768	penicillin binding
H7680_RS06945	COG2116	formate transmembrane transporter activity
H7680_RS06955	COG1827	regulation of RNA biosynthetic process
H7680_RS06975	COG2217	Heavy metal translocating P-type atpase
H7680_RS07000	COG2755	lipolytic protein G-D-S-L family
H7680_RS07020	COG0497	DNA recombination
H7680_RS07025	COG1438	arginine binding
H7680_RS07030	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H7680_RS07050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7680_RS07060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7680_RS07065	COG0415	Belongs to the DNA photolyase family
H7680_RS07090	COG0765	amino acid transport
H7680_RS07095	COG4703	Protein of unknown function (DUF1797)
H7680_RS07100	COG0542	response to heat
H7680_RS07120	COG3599	regulation of cell shape
H7680_RS07140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7680_RS07185	COG1217	gtp-binding protein TYPA
H7680_RS07190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7680_RS07195	COG1940	carbohydrate kinase activity
H7680_RS07205	COG0783	Belongs to the Dps family
H7680_RS07215	COG1132	(ABC) transporter
H7680_RS07220	COG1132	(ABC) transporter
H7680_RS07230	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7680_RS07235	COG4470	Protein conserved in bacteria
H7680_RS07255	COG1129	ABC transporter
H7680_RS07260	COG1869	D-ribose catabolic process
H7680_RS07265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7680_RS07270	COG1609	Transcriptional regulator
H7680_RS07275	COG3480	Lon protease (S16) C-terminal proteolytic domain
H7680_RS07285	COG0742	ribosomal rna small subunit methyltransferase
H7680_RS07295	COG0549	Belongs to the carbamate kinase family
H7680_RS07305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7680_RS07310	COG1288	antiporter activity
H7680_RS07320	COG0454	-acetyltransferase
H7680_RS07325	COG2235	arginine
H7680_RS07330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7680_RS07350	COG2972	Histidine kinase
H7680_RS07365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7680_RS07370	COG0785	Cytochrome C biogenesis protein
H7680_RS07380	COG0673	inositol 2-dehydrogenase activity
H7680_RS07385	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H7680_RS07390	COG1518	maintenance of DNA repeat elements
H7680_RS07435	COG0346	lactoylglutathione lyase activity
H7680_RS07455	COG0534	Mate efflux family protein
H7680_RS07505	COG0433	COG0433 Predicted ATPase
H7680_RS07550	COG1396	sequence-specific DNA binding
H7680_RS07565	COG1674	ftsk spoiiie
H7680_RS07645	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H7680_RS07645	COG1605	Chorismate mutase
H7680_RS07680	COG3250	beta-galactosidase activity
H7680_RS07685	COG4753	response regulator
H7680_RS07685	COG2207	Transcriptional regulator
H7680_RS07690	COG2972	Histidine kinase
H7680_RS07700	COG1653	transport
H7680_RS07705	COG0395	ABC-type sugar transport system, permease component
H7680_RS07710	COG1175	transmembrane transport
H7680_RS07730	COG2723	6-phospho-beta-galactosidase activity
H7680_RS07735	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H7680_RS07750	COG0383	alpha-mannosidase activity
H7680_RS07765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7680_RS07775	COG2070	2-Nitropropane dioxygenase
H7680_RS07780	COG0183	Belongs to the thiolase family
H7680_RS07785	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7680_RS07785	COG1024	Enoyl-CoA hydratase
H7680_RS07885	COG1040	competence protein
H7680_RS07890	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H7680_RS07895	COG1739	Uncharacterized protein family UPF0029
H7680_RS07905	COG1098	S1 RNA binding domain
H7680_RS07915	COG2197	response regulator
H7680_RS07920	COG4585	Histidine kinase
H7680_RS07930	COG2815	serine threonine protein kinase
H7680_RS07930	COG0515	serine threonine protein kinase
H7680_RS07940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7680_RS07940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7680_RS07950	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7680_RS07975	COG0183	Belongs to the thiolase family
H7680_RS07980	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7680_RS08010	COG0116	Belongs to the methyltransferase superfamily
H7680_RS08035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7680_RS08040	COG3579	cysteine-type endopeptidase activity
H7680_RS08050	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7680_RS08055	COG1113	amino acid transport
H7680_RS08060	COG0492	ferredoxin-NADP+ reductase activity
H7680_RS08070	COG1126	abc transporter atp-binding protein
H7680_RS08075	COG0765	amino acid transport
H7680_RS08085	COG0513	Belongs to the DEAD box helicase family
H7680_RS08095	COG0768	penicillin binding
H7680_RS08125	COG1131	(ABC) transporter
H7680_RS08150	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7680_RS08155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7680_RS08190	COG1755	Isoprenylcysteine carboxyl methyltransferase
H7680_RS08195	COG0656	L-ascorbic acid biosynthetic process
H7680_RS08205	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7680_RS08225	COG0561	phosphatase activity
H7680_RS08230	COG2860	membrane
H7680_RS08240	COG1105	Belongs to the carbohydrate kinase PfkB family
H7680_RS08265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7680_RS08280	COG2217	Heavy metal translocating P-type atpase
H7680_RS08310	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H7680_RS08315	COG0195	Participates in both transcription termination and antitermination
H7680_RS08340	COG4473	ABC transporter
H7680_RS08345	COG1131	(ABC) transporter
H7680_RS08350	COG0537	adenosine 5'-monophosphoramidase activity
H7680_RS08360	COG1316	TRANSCRIPTIONal
H7680_RS08365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7680_RS08370	COG0802	atpase or kinase
H7680_RS08375	COG2252	PERMEase
H7680_RS08380	COG0561	phosphatase activity
H7680_RS08390	COG3715	PTS system
H7680_RS08395	COG3716	PTS system mannose fructose sorbose family IID component
H7680_RS08425	COG0439	Biotin carboxylase
H7680_RS08440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7680_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
H7680_RS08450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7680_RS08455	COG2070	2-Nitropropane dioxygenase
H7680_RS08475	COG1024	Enoyl-CoA hydratase
H7680_RS08480	COG0484	heat shock protein binding
H7680_RS08500	COG1420	regulation of RNA biosynthetic process
H7680_RS08515	COG0588	phosphoglycerate mutase activity
H7680_RS08520	COG2261	transglycosylase associated protein
H7680_RS08545	COG0574	Belongs to the PEP-utilizing enzyme family
H7680_RS08545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7680_RS08550	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7680_RS08555	COG0517	IMP dehydrogenase activity
H7680_RS08565	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7680_RS08575	COG1937	Protein conserved in bacteria
H7680_RS08580	COG1335	isochorismatase
H7680_RS08590	COG0436	Aminotransferase
H7680_RS08600	COG0561	phosphatase activity
H7680_RS08605	COG0252	asparaginase activity
H7680_RS08610	COG4989	oxidoreductase activity
H7680_RS08615	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7680_RS08620	COG1129	ABC transporter
H7680_RS08635	COG1132	(ABC) transporter
H7680_RS08640	COG4988	ABC transporter
H7680_RS08645	COG1120	ATPase activity
H7680_RS08670	COG3942	CHAP domain
H7680_RS08670	COG1388	LysM domain
H7680_RS08690	COG1482	cell wall glycoprotein biosynthetic process
H7680_RS08695	COG1940	carbohydrate kinase activity
H7680_RS08700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7680_RS08700	COG1263	PTS System
H7680_RS08700	COG2190	(PTS) system
H7680_RS08705	COG1621	beta-fructofuranosidase activity
H7680_RS08710	COG1609	Transcriptional regulator
H7680_RS08730	COG2131	deaminase
H7680_RS08735	COG0006	proline dipeptidase activity
H7680_RS08770	COG1194	a g-specific adenine glycosylase
H7680_RS08775	COG3118	belongs to the thioredoxin family
H7680_RS08780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7680_RS08805	COG0681	Belongs to the peptidase S26 family
H7680_RS08810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7680_RS08825	COG1882	Formate acetyltransferase
H7680_RS08830	COG2153	protein acetylation
H7680_RS08840	COG1653	transport
H7680_RS08850	COG0395	ABC-type sugar transport system, permease component
H7680_RS08855	COG4209	transmembrane transport
H7680_RS08865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7680_RS08880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7680_RS08910	COG0789	Transcriptional regulator
H7680_RS08925	COG2081	HI0933 family
H7680_RS08960	COG1214	PFAM Peptidase M22, glycoprotease
H7680_RS08965	COG5503	Protein of unknown function (DUF1447)
H7680_RS08975	COG4608	Belongs to the ABC transporter superfamily
H7680_RS08980	COG0444	Belongs to the ABC transporter superfamily
H7680_RS08985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7680_RS08990	COG0601	transmembrane transport
H7680_RS08995	COG4166	transmembrane transport
H7680_RS09000	COG0174	glutamine synthetase
H7680_RS09005	COG0789	Transcriptional regulator
H7680_RS09020	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H7680_RS09050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7680_RS09065	COG1564	THIamine pyrophosphokinase
H7680_RS09090	COG0084	hydrolase, TatD family'
H7680_RS09095	COG1335	isochorismatase
H7680_RS09110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7680_RS09125	COG0395	ABC-type sugar transport system, permease component
H7680_RS09130	COG1175	transmembrane transport
H7680_RS09150	COG1847	R3H domain protein
H7680_RS09215	COG0756	dUTP diphosphatase activity
H7680_RS09225	COG1132	(ABC) transporter
H7680_RS09230	COG1132	(ABC) transporter
H7680_RS09245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7680_RS09255	COG0457	Tetratricopeptide repeat
H7680_RS09255	COG0705	Rhomboid family
H7680_RS09260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7680_RS09295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7680_RS09330	COG4869	propanediol catabolic process
H7680_RS09335	COG1012	belongs to the aldehyde dehydrogenase family
H7680_RS09335	COG1454	alcohol dehydrogenase
H7680_RS09345	COG4766	ethanolamine catabolic process
H7680_RS09350	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
H7680_RS09380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7680_RS09385	COG1882	Formate acetyltransferase
H7680_RS09390	COG1012	belongs to the aldehyde dehydrogenase family
H7680_RS09390	COG1454	alcohol dehydrogenase
H7680_RS09395	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H7680_RS09400	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
H7680_RS09420	COG4978	Transcriptional regulator
H7680_RS09420	COG0789	Transcriptional regulator
H7680_RS09440	COG1234	tRNA 3'-trailer cleavage
H7680_RS09445	COG1268	BioY protein
H7680_RS09470	COG1832	CoA-binding protein
H7680_RS09475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7680_RS09475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7680_RS09485	COG3448	diguanylate cyclase activity
H7680_RS09485	COG4175	Glycine betaine
H7680_RS09490	COG1597	lipid kinase activity
H7680_RS09510	COG3623	hexulose-6-phosphate isomerase
H7680_RS09560	COG1132	(ABC) transporter
H7680_RS09565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7680_RS09615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7680_RS09630	COG0564	pseudouridine synthase activity
H7680_RS09645	COG1051	belongs to the nudix hydrolase family
H7680_RS09660	COG0542	response to heat
H7680_RS09665	COG4463	regulation of RNA biosynthetic process
H7680_RS09690	COG0450	alkyl hydroperoxide reductase
H7680_RS09705	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7680_RS09715	COG3404	Formiminotransferase-cyclodeaminase
H7680_RS09730	COG0531	amino acid
H7680_RS09760	COG3590	peptidase
H7680_RS09765	COG0366	Alpha amylase catalytic
H7680_RS09770	COG1263	PTS System
H7680_RS09770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7680_RS09775	COG2188	Transcriptional regulator
H7680_RS09785	COG2514	catechol 2,3-dioxygenase activity
H7680_RS09795	COG0602	queuosine metabolic process
H7680_RS09835	COG4472	Bacterial protein of unknown function (DUF965)
H7680_RS09840	COG1393	Belongs to the ArsC family
H7680_RS09860	COG0519	Catalyzes the synthesis of GMP from XMP
H7680_RS09870	COG2814	Major facilitator Superfamily
H7680_RS09900	COG0488	(ABC) transporter
H7680_RS09905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7680_RS09910	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7680_RS09915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7680_RS10020	COG1511	domain protein
H7680_RS10160	COG0582	viral genome integration into host DNA
H7680_RS10165	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7680_RS10180	COG0305	Participates in initiation and elongation during chromosome replication
H7680_RS10215	COG1760	l-serine dehydratase
H7680_RS10220	COG1760	l-serine dehydratase
H7680_RS10230	COG0741	lytic transglycosylase activity
H7680_RS10250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7680_RS10260	COG0612	Peptidase, M16
H7680_RS10285	COG0517	IMP dehydrogenase activity
H7680_RS10285	COG0516	GMP reductase activity
H7680_RS10295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7680_RS10300	COG0488	(ABC) transporter
H7680_RS10335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain