locus-tag	class	description
H7678_RS00010	COG0592	DNA-directed DNA polymerase activity
H7678_RS00025	COG0012	GTP binding
H7678_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H7678_RS00040	COG2244	polysaccharide biosynthetic process
H7678_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H7678_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H7678_RS00075	COG0531	amino acid
H7678_RS00255	COG3942	CHAP domain
H7678_RS00275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H7678_RS00280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H7678_RS00285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H7678_RS00295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H7678_RS00300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H7678_RS00315	COG3942	CHAP domain
H7678_RS00320	COG0151	Belongs to the GarS family
H7678_RS00330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H7678_RS00350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H7678_RS00365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H7678_RS00380	COG1012	belongs to the aldehyde dehydrogenase family
H7678_RS00380	COG1454	alcohol dehydrogenase
H7678_RS00385	COG1064	alcohol dehydrogenase
H7678_RS00390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H7678_RS00405	COG0051	transcription antitermination factor activity, RNA binding
H7678_RS00505	COG0200	Binds to the 23S rRNA
H7678_RS00510	COG0201	protein transport
H7678_RS00530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H7678_RS00640	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H7678_RS00650	COG1252	NADH dehydrogenase
H7678_RS00655	COG1271	oxidase subunit
H7678_RS00660	COG1294	oxidase, subunit
H7678_RS00665	COG4988	ABC transporter
H7678_RS00670	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H7678_RS00675	COG0142	geranyltranstransferase activity
H7678_RS00690	COG1121	(ABC) transporter
H7678_RS00695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H7678_RS00705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7678_RS00705	COG4499	WXG100 protein secretion system (Wss), protein YukC
H7678_RS00725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H7678_RS00730	COG1459	type II secretion system
H7678_RS00735	COG4537	Required for transformation and DNA binding
H7678_RS00775	COG1266	CAAX protease self-immunity
H7678_RS00785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H7678_RS00790	COG1363	Peptidase, m42
H7678_RS00800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7678_RS00805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H7678_RS00830	COG4120	Belongs to the binding-protein-dependent transport system permease family
H7678_RS00845	COG1428	Deoxynucleoside kinase
H7678_RS00850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H7678_RS00920	COG0251	oxidation-reduction process
H7678_RS00945	COG1744	ABC transporter substrate-binding protein PnrA-like
H7678_RS00950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7678_RS00955	COG1349	DNA-binding transcription factor activity
H7678_RS00960	COG2390	Transcriptional regulator
H7678_RS00965	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7678_RS00970	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7678_RS00975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7678_RS00980	COG1882	Formate acetyltransferase
H7678_RS01000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H7678_RS01025	COG3655	Transcriptional regulator
H7678_RS01040	COG0488	(ABC) transporter
H7678_RS01090	COG1132	(ABC) transporter
H7678_RS01155	COG0582	viral genome integration into host DNA
H7678_RS01170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H7678_RS01175	COG0512	Glutamine amidotransferase of anthranilate synthase
H7678_RS01180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H7678_RS01210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H7678_RS01215	COG1609	Transcriptional regulator
H7678_RS01220	COG1263	PTS System
H7678_RS01220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7678_RS01220	COG2190	(PTS) system
H7678_RS01235	COG1363	Peptidase, m42
H7678_RS01265	COG0737	Belongs to the 5'-nucleotidase family
H7678_RS01290	COG3842	ATPase activity
H7678_RS01300	COG1523	belongs to the glycosyl hydrolase 13 family
H7678_RS01315	COG1862	Preprotein translocase
H7678_RS01325	COG4589	Belongs to the CDS family
H7678_RS01350	COG1846	Transcriptional regulator
H7678_RS01380	COG3711	transcriptional antiterminator
H7678_RS01395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H7678_RS01410	COG1045	serine acetyltransferase
H7678_RS01425	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H7678_RS01445	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7678_RS01465	COG1476	TRANSCRIPTIONal
H7678_RS01475	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H7678_RS01485	COG4974	Belongs to the 'phage' integrase family
H7678_RS01570	COG3775	system Galactitol-specific IIC component
H7678_RS01575	COG3414	Phosphotransferase system galactitol-specific IIB component
H7678_RS01595	COG0561	phosphatase activity
H7678_RS01635	COG0527	aspartate kinase activity
H7678_RS01645	COG0351	phosphomethylpyrimidine kinase
H7678_RS01650	COG4720	Psort location CytoplasmicMembrane, score
H7678_RS01660	COG0668	transmembrane transport
H7678_RS01670	COG0366	Alpha amylase catalytic
H7678_RS01680	COG3343	RNA polymerase activity
H7678_RS01695	COG3279	Response regulator of the LytR AlgR family
H7678_RS01705	COG1346	cytolysis
H7678_RS01755	COG0765	amino acid transport
H7678_RS01775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H7678_RS01785	COG0719	Fe-S assembly protein
H7678_RS01790	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H7678_RS01805	COG1686	Belongs to the peptidase S11 family
H7678_RS01810	COG1686	Belongs to the peptidase S11 family
H7678_RS01815	COG4166	transmembrane transport
H7678_RS01820	COG0601	transmembrane transport
H7678_RS01825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7678_RS01830	COG0444	Belongs to the ABC transporter superfamily
H7678_RS01885	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H7678_RS01890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H7678_RS01895	COG1534	Rna-binding protein
H7678_RS01905	COG1713	HD superfamily hydrolase involved in NAD metabolism
H7678_RS01915	COG0799	negative regulation of ribosome biogenesis
H7678_RS01920	COG2226	methyltransferase
H7678_RS01930	COG0789	Transcriptional regulator
H7678_RS01945	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H7678_RS01955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7678_RS01965	COG1464	Belongs to the NlpA lipoprotein family
H7678_RS01970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7678_RS01985	COG1114	Component of the transport system for branched-chain amino acids
H7678_RS01995	COG0569	domain protein
H7678_RS02000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H7678_RS02010	COG1704	LemA family
H7678_RS02025	COG0745	RESPONSE REGULATOR receiver
H7678_RS02030	COG5002	protein histidine kinase activity
H7678_RS02035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7678_RS02045	COG1484	DNA-dependent DNA replication
H7678_RS02055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H7678_RS02075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H7678_RS02090	COG1254	Belongs to the acylphosphatase family
H7678_RS02095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H7678_RS02130	COG4175	Glycine betaine
H7678_RS02150	COG1187	pseudouridine synthase activity
H7678_RS02165	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
H7678_RS02170	COG0671	phosphoesterase, PA-phosphatase related
H7678_RS02175	COG1242	4 iron, 4 sulfur cluster binding
H7678_RS02180	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H7678_RS02185	COG1253	flavin adenine dinucleotide binding
H7678_RS02190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H7678_RS02195	COG5433	transposase activity
H7678_RS02210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7678_RS02215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H7678_RS02220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H7678_RS02225	COG1120	ATPase activity
H7678_RS02235	COG2244	polysaccharide biosynthetic process
H7678_RS02275	COG0559	Belongs to the binding-protein-dependent transport system permease family
H7678_RS02285	COG0411	ABC transporter
H7678_RS02295	COG0517	IMP dehydrogenase activity
H7678_RS02305	COG0470	DNA polymerase III
H7678_RS02310	COG1774	PSP1 C-terminal conserved region
H7678_RS02335	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H7678_RS02350	COG1393	Belongs to the ArsC family
H7678_RS02365	COG1609	Transcriptional regulator
H7678_RS02370	COG0561	phosphatase activity
H7678_RS02375	COG0708	Exodeoxyribonuclease III
H7678_RS02385	COG1620	l-lactate permease
H7678_RS02390	COG1304	FMN binding
H7678_RS02430	COG1114	Component of the transport system for branched-chain amino acids
H7678_RS02445	COG1028	Short-chain dehydrogenase reductase Sdr
H7678_RS02460	COG0673	inositol 2-dehydrogenase activity
H7678_RS02485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H7678_RS02510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H7678_RS02575	COG1702	phosphate starvation-inducible protein PhoH
H7678_RS02580	COG1573	uracil-dna glycosylase
H7678_RS02590	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H7678_RS02635	COG3279	Response regulator of the LytR AlgR family
H7678_RS02655	COG2274	protein secretion by the type I secretion system
H7678_RS02710	COG1396	sequence-specific DNA binding
H7678_RS02725	COG1131	(ABC) transporter
H7678_RS02735	COG0433	COG0433 Predicted ATPase
H7678_RS02740	COG2814	Major facilitator Superfamily
H7678_RS02755	COG0557	exoribonuclease II activity
H7678_RS02760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H7678_RS02775	COG0463	Glycosyl transferase, family 2
H7678_RS02785	COG0346	lactoylglutathione lyase activity
H7678_RS02790	COG0778	Nitroreductase
H7678_RS02795	COG0006	proline dipeptidase activity
H7678_RS02800	COG1609	Transcriptional regulator
H7678_RS02815	COG0438	transferase activity, transferring glycosyl groups
H7678_RS02825	COG4555	ABC transporter
H7678_RS02840	COG2376	Dihydroxyacetone kinase
H7678_RS02850	COG2376	Dihydroxyacetone kinase
H7678_RS02855	COG1461	Dihydroxyacetone kinase
H7678_RS02860	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H7678_RS02865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7678_RS02875	COG0183	Belongs to the thiolase family
H7678_RS02880	COG0318	PFAM AMP-dependent synthetase and ligase
H7678_RS02890	COG0765	amino acid transport
H7678_RS02895	COG0765	amino acid transport
H7678_RS02900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7678_RS02910	COG0745	RESPONSE REGULATOR receiver
H7678_RS02915	COG5002	protein histidine kinase activity
H7678_RS02920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H7678_RS02930	COG1196	nuclear chromosome segregation
H7678_RS02950	COG5433	transposase activity
H7678_RS02955	COG0561	phosphatase activity
H7678_RS02960	COG0561	phosphatase activity
H7678_RS02965	COG0552	protein localization to endoplasmic reticulum
H7678_RS02970	COG3689	TIGRFAM TIGR03943 family protein
H7678_RS02975	COG0701	Predicted permease
H7678_RS02990	COG0745	RESPONSE REGULATOR receiver
H7678_RS02995	COG5002	protein histidine kinase activity
H7678_RS03000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H7678_RS03005	COG0573	inorganic phosphate transmembrane transporter activity
H7678_RS03015	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H7678_RS03020	COG0704	Plays a role in the regulation of phosphate uptake
H7678_RS03030	COG2183	response to ionizing radiation
H7678_RS03075	COG0826	peptidase U32
H7678_RS03080	COG4443	Transcriptional Coactivator p15 (PC4)
H7678_RS03095	COG0004	ammonium transporteR
H7678_RS03100	COG0582	viral genome integration into host DNA
H7678_RS03110	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7678_RS03110	COG3942	CHAP domain
H7678_RS03130	COG0433	COG0433 Predicted ATPase
H7678_RS03180	COG1674	ftsk spoiiie
H7678_RS03200	COG3620	sequence-specific DNA binding
H7678_RS03220	COG3620	sequence-specific DNA binding
H7678_RS03225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H7678_RS03275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H7678_RS03305	COG0386	Belongs to the glutathione peroxidase family
H7678_RS03310	COG1164	Oligoendopeptidase f
H7678_RS03320	COG0772	Belongs to the SEDS family
H7678_RS03325	COG1191	sigma factor activity
H7678_RS03400	COG1078	dGTPase activity
H7678_RS03420	COG1609	Transcriptional regulator
H7678_RS03430	COG3716	PTS system mannose fructose sorbose family IID component
H7678_RS03435	COG3715	PTS system
H7678_RS03440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7678_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
H7678_RS03475	COG5492	domain, Protein
H7678_RS03495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H7678_RS03500	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H7678_RS03505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H7678_RS03515	COG2884	Cell division ATP-binding protein ftsE
H7678_RS03520	COG2177	Part of the ABC transporter FtsEX involved in
H7678_RS03530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H7678_RS03530	COG1199	ATP-dependent helicase activity
H7678_RS03535	COG0436	Aminotransferase
H7678_RS03540	COG0017	Asparaginyl-tRNA synthetase
H7678_RS03580	COG2188	Transcriptional regulator
H7678_RS03585	COG2222	sugar isomerase
H7678_RS03610	COG3715	PTS system
H7678_RS03615	COG3716	PTS system mannose fructose sorbose family IID component
H7678_RS03635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H7678_RS03640	COG2153	protein acetylation
H7678_RS03645	COG0625	glutathione transferase activity
H7678_RS03655	COG0716	FMN binding
H7678_RS03665	COG0038	chloride channel
H7678_RS03680	COG0772	Belongs to the SEDS family
H7678_RS03700	COG0560	Phosphoserine phosphatase
H7678_RS03745	COG1131	(ABC) transporter
H7678_RS03765	COG4708	membrane
H7678_RS03775	COG1597	lipid kinase activity
H7678_RS03780	COG1523	belongs to the glycosyl hydrolase 13 family
H7678_RS03785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
H7678_RS03790	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7678_RS03795	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
H7678_RS03885	COG0577	efflux transmembrane transporter activity
H7678_RS03895	COG2321	neutral zinc metallopeptidase
H7678_RS03910	COG0436	Aminotransferase
H7678_RS03925	COG1970	mechanosensitive ion channel activity
H7678_RS03930	COG0358	DNA primase activity
H7678_RS03935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H7678_RS03940	COG2151	metal-sulfur cluster biosynthetic enzyme
H7678_RS03955	COG1442	glycosyl transferase family 8
H7678_RS03955	COG1216	Glycosyl transferase, family 2
H7678_RS03995	COG0463	Glycosyl transferase, family 2
H7678_RS04010	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H7678_RS04060	COG1368	sulfuric ester hydrolase activity
H7678_RS04065	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H7678_RS04085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7678_RS04090	COG0285	dihydrofolate synthase activity
H7678_RS04100	COG1104	cysteine desulfurase activity
H7678_RS04130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H7678_RS04135	COG0583	DNA-binding transcription factor activity
H7678_RS04145	COG0564	pseudouridine synthase activity
H7678_RS04180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H7678_RS04185	COG1136	(ABC) transporter
H7678_RS04190	COG0577	efflux transmembrane transporter activity
H7678_RS04200	COG0584	glycerophosphoryl diester phosphodiesterase
H7678_RS04210	COG1837	Belongs to the UPF0109 family
H7678_RS04245	COG1349	DNA-binding transcription factor activity
H7678_RS04250	COG1105	Belongs to the carbohydrate kinase PfkB family
H7678_RS04255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7678_RS04255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7678_RS04255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H7678_RS04260	COG1388	LysM domain
H7678_RS04260	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7678_RS04265	COG1388	LysM domain
H7678_RS04265	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7678_RS04290	COG0488	(ABC) transporter
H7678_RS04300	COG1132	(ABC) transporter
H7678_RS04305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H7678_RS04310	COG0242	peptide deformylase activity
H7678_RS04315	COG0737	Belongs to the 5'-nucleotidase family
H7678_RS04325	COG1132	(ABC) transporter
H7678_RS04330	COG1132	(ABC) transporter
H7678_RS04380	COG3425	synthase
H7678_RS04390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7678_RS04450	COG0270	DNA (cytosine-5-)-methyltransferase activity
H7678_RS04610	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7678_RS04620	COG1131	(ABC) transporter
H7678_RS04625	COG0842	Transport permease protein
H7678_RS04640	COG2217	Heavy metal translocating P-type atpase
H7678_RS04645	COG0640	Transcriptional regulator
H7678_RS04660	COG0860	N-Acetylmuramoyl-L-alanine amidase
H7678_RS04660	COG1388	LysM domain
H7678_RS04700	COG2217	Heavy metal translocating P-type atpase
H7678_RS04705	COG2217	Heavy metal translocating P-type atpase
H7678_RS04750	COG3843	relaxase mobilization nuclease domain protein
H7678_RS04755	COG1396	sequence-specific DNA binding
H7678_RS04765	COG4974	Belongs to the 'phage' integrase family
H7678_RS04775	COG1686	Belongs to the peptidase S11 family
H7678_RS04780	COG0726	polysaccharide deacetylase
H7678_RS04795	COG0285	dihydrofolate synthase activity
H7678_RS04800	COG0302	gtp cyclohydrolase
H7678_RS04830	COG1176	ABC-type spermidine putrescine transport system, permease component I
H7678_RS04835	COG1177	transmembrane transport
H7678_RS04865	COG0038	chloride channel
H7678_RS04870	COG4977	sequence-specific DNA binding
H7678_RS04870	COG1917	Cupin 2, conserved barrel domain protein
H7678_RS04880	COG0628	permease
H7678_RS04890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H7678_RS04910	COG1104	cysteine desulfurase activity
H7678_RS04925	COG2357	RelA SpoT domain protein
H7678_RS04935	COG0564	pseudouridine synthase activity
H7678_RS04940	COG0280	phosphate acetyltransferase
H7678_RS04960	COG1174	glycine betaine transport
H7678_RS04975	COG2233	PERMEase
H7678_RS05000	COG2890	protein-(glutamine-N5) methyltransferase activity
H7678_RS05005	COG0009	L-threonylcarbamoyladenylate synthase
H7678_RS05030	COG1132	(ABC) transporter
H7678_RS05035	COG1132	(ABC) transporter
H7678_RS05045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H7678_RS05060	COG3764	Sortase (surface protein transpeptidase)
H7678_RS05065	COG0346	lactoylglutathione lyase activity
H7678_RS05105	COG1136	(ABC) transporter
H7678_RS05110	COG0577	efflux transmembrane transporter activity
H7678_RS05115	COG0745	RESPONSE REGULATOR receiver
H7678_RS05120	COG2205	protein histidine kinase activity
H7678_RS05125	COG1705	Flagellar rod assembly protein muramidase FlgJ
H7678_RS05125	COG3942	CHAP domain
H7678_RS05145	COG5433	transposase activity
H7678_RS05150	COG0803	Belongs to the bacterial solute-binding protein 9 family
H7678_RS05170	COG1122	ATPase activity
H7678_RS05180	COG0601	transmembrane transport
H7678_RS05225	COG2188	Transcriptional regulator
H7678_RS05235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H7678_RS05260	COG0673	inositol 2-dehydrogenase activity
H7678_RS05265	COG0745	RESPONSE REGULATOR receiver
H7678_RS05270	COG5002	protein histidine kinase activity
H7678_RS05275	COG0662	Cupin 2, conserved barrel domain protein
H7678_RS05305	COG4939	FMN-binding domain protein
H7678_RS05310	COG0142	geranyltranstransferase activity
H7678_RS05315	COG1252	NADH dehydrogenase
H7678_RS05325	COG5002	protein histidine kinase activity
H7678_RS05330	COG0745	RESPONSE REGULATOR receiver
H7678_RS05335	COG0577	efflux transmembrane transporter activity
H7678_RS05340	COG1136	(ABC) transporter
H7678_RS05355	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
H7678_RS05400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7678_RS05405	COG0758	DNA mediated transformation
H7678_RS05435	COG1272	protein, Hemolysin III
H7678_RS05455	COG0488	(ABC) transporter
H7678_RS05475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H7678_RS05480	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H7678_RS05480	COG1328	CTP reductase activity
H7678_RS05485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H7678_RS05490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H7678_RS05550	COG0095	Lipoate-protein ligase
H7678_RS05560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H7678_RS05565	COG4684	Psort location CytoplasmicMembrane, score
H7678_RS05570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7678_RS05575	COG1079	Belongs to the binding-protein-dependent transport system permease family
H7678_RS05580	COG4603	Belongs to the binding-protein-dependent transport system permease family
H7678_RS05585	COG3845	ABC transporter
H7678_RS05590	COG1744	ABC transporter substrate-binding protein PnrA-like
H7678_RS05605	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
H7678_RS05610	COG2813	Specifically methylates the guanine in position
H7678_RS05625	COG5002	protein histidine kinase activity
H7678_RS05630	COG0745	RESPONSE REGULATOR receiver
H7678_RS05640	COG0704	Plays a role in the regulation of phosphate uptake
H7678_RS05655	COG0581	inorganic phosphate transmembrane transporter activity
H7678_RS05660	COG0573	inorganic phosphate transmembrane transporter activity
H7678_RS05670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7678_RS05670	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
H7678_RS05675	COG0483	inositol monophosphate 1-phosphatase activity
H7678_RS05690	COG0196	riboflavin kinase activity
H7678_RS05720	COG4591	ABC-type transport system involved in lipoprotein release permease component
H7678_RS05720	COG1136	(ABC) transporter
H7678_RS05760	COG2261	transglycosylase associated protein
H7678_RS05770	COG1115	amino acid carrier protein
H7678_RS05775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H7678_RS05785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H7678_RS05790	COG1126	abc transporter atp-binding protein
H7678_RS05795	COG0765	amino acid transport
H7678_RS05800	COG2824	Alkylphosphonate utilization operon protein PhnA
H7678_RS05815	COG0469	pyruvate kinase activity
H7678_RS05830	COG1725	Transcriptional regulator
H7678_RS05835	COG1131	(ABC) transporter
H7678_RS05845	COG0398	Pfam SNARE associated Golgi protein
H7678_RS05865	COG0539	negative regulation of cytoplasmic translation
H7678_RS05885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H7678_RS05900	COG0187	DNA topoisomerase II activity
H7678_RS05920	COG0765	amino acid transport
H7678_RS05975	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H7678_RS06000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7678_RS06010	COG0028	Belongs to the TPP enzyme family
H7678_RS06020	COG0028	Belongs to the TPP enzyme family
H7678_RS06035	COG1012	belongs to the aldehyde dehydrogenase family
H7678_RS06040	COG1011	Hydrolase
H7678_RS06050	COG0701	Predicted permease
H7678_RS06075	COG4753	response regulator
H7678_RS06075	COG2207	Transcriptional regulator
H7678_RS06080	COG2972	Histidine kinase
H7678_RS06085	COG3716	PTS system mannose fructose sorbose family IID component
H7678_RS06090	COG3715	PTS system
H7678_RS06150	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H7678_RS06155	COG1518	maintenance of DNA repeat elements
H7678_RS06170	COG0647	UMP catabolic process
H7678_RS06180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H7678_RS06200	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H7678_RS06205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7678_RS06210	COG3442	glutamine amidotransferase
H7678_RS06215	COG0095	Lipoate-protein ligase
H7678_RS06225	COG1695	Transcriptional regulator
H7678_RS06235	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7678_RS06240	COG0022	dehydrogenase e1 component
H7678_RS06240	COG0508	dehydrogenase complex catalyzes the overall conversion of
H7678_RS06245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H7678_RS06250	COG0488	(ABC) transporter
H7678_RS06270	COG1122	ATPase activity
H7678_RS06300	COG3700	Belongs to the class B bacterial acid phosphatase family
H7678_RS06320	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H7678_RS06325	COG0457	Tetratricopeptide repeat
H7678_RS06330	COG0628	permease
H7678_RS06335	COG1051	belongs to the nudix hydrolase family
H7678_RS06355	COG1088	dTDP-glucose 4,6-dehydratase activity
H7678_RS06365	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H7678_RS06370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H7678_RS06385	COG2384	SAM-dependent methyltransferase
H7678_RS06390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H7678_RS06405	COG5433	transposase activity
H7678_RS06410	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H7678_RS06410	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H7678_RS06415	COG0300	oxidoreductase activity
H7678_RS06430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H7678_RS06455	COG0572	uridine kinase
H7678_RS06460	COG1054	Belongs to the UPF0176 family
H7678_RS06470	COG0431	NADPH-dependent FMN reductase
H7678_RS06475	COG0058	SHG alpha-glucan phosphorylase activity
H7678_RS06480	COG1640	4-alpha-glucanotransferase
H7678_RS06485	COG1609	Transcriptional regulator
H7678_RS06495	COG2182	Extracellular solute-binding protein
H7678_RS06505	COG3833	ABC-type maltose transport systems, permease component
H7678_RS06520	COG3833	ABC-type maltose transport systems, permease component
H7678_RS06530	COG0366	Alpha amylase catalytic
H7678_RS06535	COG2182	Extracellular solute-binding protein
H7678_RS06540	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H7678_RS06550	COG1696	Membrane protein involved in D-alanine export
H7678_RS06570	COG0765	amino acid transport
H7678_RS06575	COG1126	abc transporter atp-binding protein
H7678_RS06585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H7678_RS06595	COG1447	Phosphotransferase system cellobiose-specific component IIA
H7678_RS06605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7678_RS06605	COG3711	transcriptional antiterminator
H7678_RS06615	COG2723	6-phospho-beta-galactosidase activity
H7678_RS06640	COG2309	aminopeptidase activity
H7678_RS06650	COG1187	pseudouridine synthase activity
H7678_RS06660	COG2814	Major facilitator Superfamily
H7678_RS06670	COG0390	transport system, permease component
H7678_RS06675	COG4619	ABC transporter
H7678_RS06690	COG1464	Belongs to the NlpA lipoprotein family
H7678_RS06740	COG0534	Mate efflux family protein
H7678_RS06745	COG1129	ABC transporter
H7678_RS06760	COG1132	(ABC) transporter
H7678_RS06765	COG1132	(ABC) transporter
H7678_RS06765	COG2375	cellular response to nickel ion
H7678_RS06770	COG1309	transcriptional regulator
H7678_RS06785	COG4581	dead DEAH box helicase
H7678_RS06820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H7678_RS06820	COG0551	DNA topoisomerase type I activity
H7678_RS06955	COG1725	Transcriptional regulator
H7678_RS07055	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H7678_RS07085	COG4109	DRTGG domain
H7678_RS07110	COG1028	Short-chain dehydrogenase reductase Sdr
H7678_RS07115	COG1312	Catalyzes the dehydration of D-mannonate
H7678_RS07125	COG0800	Aldolase
H7678_RS07130	COG2186	Transcriptional regulator
H7678_RS07135	COG3250	beta-galactosidase activity
H7678_RS07145	COG2211	Major facilitator Superfamily
H7678_RS07165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H7678_RS07165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H7678_RS07175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H7678_RS07180	COG1956	GAF domain-containing protein
H7678_RS07200	COG0513	Belongs to the DEAD box helicase family
H7678_RS07205	COG0726	polysaccharide deacetylase
H7678_RS07225	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H7678_RS07230	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7678_RS07235	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H7678_RS07255	COG1476	TRANSCRIPTIONal
H7678_RS07280	COG4122	O-methyltransferase activity
H7678_RS07285	COG2223	nitrite transmembrane transporter activity
H7678_RS07300	COG0431	NADPH-dependent FMN reductase
H7678_RS07320	COG1187	pseudouridine synthase activity
H7678_RS07355	COG2333	competence protein COMEC
H7678_RS07355	COG0658	competence protein
H7678_RS07360	COG1596	polysaccharide export
H7678_RS07360	COG1555	photosystem II stabilization
H7678_RS07365	COG0204	Acyl-transferase
H7678_RS07370	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H7678_RS07385	COG0513	Belongs to the DEAD box helicase family
H7678_RS07390	COG1464	Belongs to the NlpA lipoprotein family
H7678_RS07400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H7678_RS07420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H7678_RS07435	COG0768	penicillin binding
H7678_RS07440	COG2116	formate transmembrane transporter activity
H7678_RS07450	COG1827	regulation of RNA biosynthetic process
H7678_RS07470	COG2217	Heavy metal translocating P-type atpase
H7678_RS07495	COG2755	lipolytic protein G-D-S-L family
H7678_RS07515	COG0497	DNA recombination
H7678_RS07520	COG1438	arginine binding
H7678_RS07525	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
H7678_RS07545	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H7678_RS07555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H7678_RS07560	COG0415	Belongs to the DNA photolyase family
H7678_RS07585	COG0765	amino acid transport
H7678_RS07590	COG4703	Protein of unknown function (DUF1797)
H7678_RS07595	COG0542	response to heat
H7678_RS07615	COG3599	regulation of cell shape
H7678_RS07635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H7678_RS07680	COG1217	gtp-binding protein TYPA
H7678_RS07685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H7678_RS07690	COG1940	carbohydrate kinase activity
H7678_RS07700	COG0783	Belongs to the Dps family
H7678_RS07710	COG1132	(ABC) transporter
H7678_RS07715	COG1132	(ABC) transporter
H7678_RS07725	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H7678_RS07730	COG4470	Protein conserved in bacteria
H7678_RS07750	COG1129	ABC transporter
H7678_RS07755	COG1869	D-ribose catabolic process
H7678_RS07760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H7678_RS07765	COG1609	Transcriptional regulator
H7678_RS07770	COG3480	Lon protease (S16) C-terminal proteolytic domain
H7678_RS07780	COG0742	ribosomal rna small subunit methyltransferase
H7678_RS07790	COG0549	Belongs to the carbamate kinase family
H7678_RS07800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H7678_RS07805	COG1288	antiporter activity
H7678_RS07815	COG0454	-acetyltransferase
H7678_RS07820	COG2235	arginine
H7678_RS07825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H7678_RS07845	COG2972	Histidine kinase
H7678_RS07860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7678_RS07865	COG0785	Cytochrome C biogenesis protein
H7678_RS07875	COG0673	inositol 2-dehydrogenase activity
H7678_RS07880	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H7678_RS07885	COG1518	maintenance of DNA repeat elements
H7678_RS07930	COG0346	lactoylglutathione lyase activity
H7678_RS07950	COG0534	Mate efflux family protein
H7678_RS07960	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H7678_RS07960	COG1605	Chorismate mutase
H7678_RS08000	COG3250	beta-galactosidase activity
H7678_RS08005	COG2207	Transcriptional regulator
H7678_RS08005	COG4753	response regulator
H7678_RS08010	COG2972	Histidine kinase
H7678_RS08020	COG1653	transport
H7678_RS08025	COG0395	ABC-type sugar transport system, permease component
H7678_RS08030	COG1175	transmembrane transport
H7678_RS08035	COG1940	carbohydrate kinase activity
H7678_RS08050	COG2723	6-phospho-beta-galactosidase activity
H7678_RS08055	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H7678_RS08070	COG0383	alpha-mannosidase activity
H7678_RS08085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H7678_RS08095	COG2070	2-Nitropropane dioxygenase
H7678_RS08100	COG0183	Belongs to the thiolase family
H7678_RS08105	COG1024	Enoyl-CoA hydratase
H7678_RS08105	COG1250	3-hydroxyacyl-CoA dehydrogenase
H7678_RS08205	COG1040	competence protein
H7678_RS08210	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H7678_RS08215	COG1739	Uncharacterized protein family UPF0029
H7678_RS08225	COG1098	S1 RNA binding domain
H7678_RS08235	COG2197	response regulator
H7678_RS08240	COG4585	Histidine kinase
H7678_RS08250	COG2815	serine threonine protein kinase
H7678_RS08250	COG0515	serine threonine protein kinase
H7678_RS08260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H7678_RS08260	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H7678_RS08270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H7678_RS08295	COG0183	Belongs to the thiolase family
H7678_RS08300	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H7678_RS08330	COG0116	Belongs to the methyltransferase superfamily
H7678_RS08355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7678_RS08360	COG3579	cysteine-type endopeptidase activity
H7678_RS08370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H7678_RS08375	COG1113	amino acid transport
H7678_RS08380	COG0492	ferredoxin-NADP+ reductase activity
H7678_RS08390	COG1126	abc transporter atp-binding protein
H7678_RS08395	COG0765	amino acid transport
H7678_RS08405	COG0513	Belongs to the DEAD box helicase family
H7678_RS08415	COG0768	penicillin binding
H7678_RS08445	COG1131	(ABC) transporter
H7678_RS08470	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7678_RS08475	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7678_RS08510	COG1755	Isoprenylcysteine carboxyl methyltransferase
H7678_RS08515	COG0656	L-ascorbic acid biosynthetic process
H7678_RS08525	COG1283	sodium-dependent phosphate transmembrane transporter activity
H7678_RS08545	COG0561	phosphatase activity
H7678_RS08550	COG2860	membrane
H7678_RS08560	COG1105	Belongs to the carbohydrate kinase PfkB family
H7678_RS08585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7678_RS08600	COG2217	Heavy metal translocating P-type atpase
H7678_RS08620	COG4509	Sortase family
H7678_RS08640	COG0662	Cupin 2, conserved barrel domain protein
H7678_RS08640	COG2207	Transcriptional regulator
H7678_RS08670	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H7678_RS08675	COG0195	Participates in both transcription termination and antitermination
H7678_RS08700	COG4473	ABC transporter
H7678_RS08705	COG1131	(ABC) transporter
H7678_RS08710	COG0537	adenosine 5'-monophosphoramidase activity
H7678_RS08720	COG1316	TRANSCRIPTIONal
H7678_RS08725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H7678_RS08730	COG0802	atpase or kinase
H7678_RS08735	COG2252	PERMEase
H7678_RS08740	COG0561	phosphatase activity
H7678_RS08750	COG3715	PTS system
H7678_RS08755	COG3716	PTS system mannose fructose sorbose family IID component
H7678_RS08785	COG0439	Biotin carboxylase
H7678_RS08800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H7678_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
H7678_RS08810	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H7678_RS08815	COG2070	2-Nitropropane dioxygenase
H7678_RS08835	COG1024	Enoyl-CoA hydratase
H7678_RS08840	COG0484	heat shock protein binding
H7678_RS08860	COG1420	regulation of RNA biosynthetic process
H7678_RS08875	COG0588	phosphoglycerate mutase activity
H7678_RS08880	COG2261	transglycosylase associated protein
H7678_RS08905	COG0574	Belongs to the PEP-utilizing enzyme family
H7678_RS08905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H7678_RS08910	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H7678_RS08915	COG0517	IMP dehydrogenase activity
H7678_RS08925	COG0446	pyridine nucleotide-disulphide oxidoreductase
H7678_RS08935	COG1937	Protein conserved in bacteria
H7678_RS08940	COG1335	isochorismatase
H7678_RS08950	COG0436	Aminotransferase
H7678_RS08960	COG0561	phosphatase activity
H7678_RS08965	COG0252	asparaginase activity
H7678_RS08970	COG4989	oxidoreductase activity
H7678_RS08975	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H7678_RS08980	COG1129	ABC transporter
H7678_RS08995	COG1132	(ABC) transporter
H7678_RS09000	COG4988	ABC transporter
H7678_RS09005	COG1120	ATPase activity
H7678_RS09030	COG3942	CHAP domain
H7678_RS09030	COG1388	LysM domain
H7678_RS09055	COG1482	cell wall glycoprotein biosynthetic process
H7678_RS09060	COG1940	carbohydrate kinase activity
H7678_RS09065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7678_RS09065	COG2190	(PTS) system
H7678_RS09065	COG1263	PTS System
H7678_RS09070	COG1621	beta-fructofuranosidase activity
H7678_RS09075	COG1609	Transcriptional regulator
H7678_RS09095	COG2131	deaminase
H7678_RS09100	COG0006	proline dipeptidase activity
H7678_RS09135	COG1194	a g-specific adenine glycosylase
H7678_RS09140	COG3118	belongs to the thioredoxin family
H7678_RS09145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H7678_RS09170	COG0681	Belongs to the peptidase S26 family
H7678_RS09175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H7678_RS09190	COG1882	Formate acetyltransferase
H7678_RS09195	COG2153	protein acetylation
H7678_RS09205	COG1653	transport
H7678_RS09220	COG4209	transmembrane transport
H7678_RS09230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H7678_RS09245	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H7678_RS09275	COG0789	Transcriptional regulator
H7678_RS09290	COG2081	HI0933 family
H7678_RS09315	COG1214	PFAM Peptidase M22, glycoprotease
H7678_RS09320	COG5503	Protein of unknown function (DUF1447)
H7678_RS09330	COG4608	Belongs to the ABC transporter superfamily
H7678_RS09335	COG0444	Belongs to the ABC transporter superfamily
H7678_RS09340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H7678_RS09345	COG0601	transmembrane transport
H7678_RS09350	COG4166	transmembrane transport
H7678_RS09355	COG0174	glutamine synthetase
H7678_RS09360	COG0789	Transcriptional regulator
H7678_RS09375	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H7678_RS09405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H7678_RS09420	COG1564	THIamine pyrophosphokinase
H7678_RS09445	COG0084	hydrolase, TatD family'
H7678_RS09450	COG1335	isochorismatase
H7678_RS09465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H7678_RS09480	COG0395	ABC-type sugar transport system, permease component
H7678_RS09485	COG1175	transmembrane transport
H7678_RS09505	COG1847	R3H domain protein
H7678_RS09570	COG0756	dUTP diphosphatase activity
H7678_RS09580	COG1132	(ABC) transporter
H7678_RS09585	COG1132	(ABC) transporter
H7678_RS09600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H7678_RS09610	COG0457	Tetratricopeptide repeat
H7678_RS09610	COG0705	Rhomboid family
H7678_RS09615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H7678_RS09645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H7678_RS09675	COG1234	tRNA 3'-trailer cleavage
H7678_RS09680	COG1268	BioY protein
H7678_RS09705	COG1832	CoA-binding protein
H7678_RS09710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7678_RS09710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H7678_RS09720	COG3448	diguanylate cyclase activity
H7678_RS09720	COG4175	Glycine betaine
H7678_RS09725	COG1597	lipid kinase activity
H7678_RS09745	COG3623	hexulose-6-phosphate isomerase
H7678_RS09755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H7678_RS09790	COG1132	(ABC) transporter
H7678_RS09795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H7678_RS09845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H7678_RS09860	COG0564	pseudouridine synthase activity
H7678_RS09890	COG0542	response to heat
H7678_RS09895	COG4463	regulation of RNA biosynthetic process
H7678_RS09930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H7678_RS09955	COG0450	alkyl hydroperoxide reductase
H7678_RS09970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H7678_RS09980	COG3404	Formiminotransferase-cyclodeaminase
H7678_RS09995	COG0531	amino acid
H7678_RS10015	COG5433	transposase activity
H7678_RS10030	COG3590	peptidase
H7678_RS10035	COG0366	Alpha amylase catalytic
H7678_RS10040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H7678_RS10040	COG1263	PTS System
H7678_RS10045	COG2188	Transcriptional regulator
H7678_RS10055	COG2514	catechol 2,3-dioxygenase activity
H7678_RS10065	COG0602	queuosine metabolic process
H7678_RS10105	COG4472	Bacterial protein of unknown function (DUF965)
H7678_RS10110	COG1393	Belongs to the ArsC family
H7678_RS10130	COG0519	Catalyzes the synthesis of GMP from XMP
H7678_RS10140	COG2814	Major facilitator Superfamily
H7678_RS10170	COG0488	(ABC) transporter
H7678_RS10175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7678_RS10180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7678_RS10185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7678_RS10265	COG1511	domain protein
H7678_RS10405	COG0582	viral genome integration into host DNA
H7678_RS10410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H7678_RS10425	COG0305	Participates in initiation and elongation during chromosome replication
H7678_RS10440	COG5433	transposase activity
H7678_RS10455	COG2095	MarC family integral membrane protein
H7678_RS10465	COG1760	l-serine dehydratase
H7678_RS10470	COG1760	l-serine dehydratase
H7678_RS10480	COG0741	lytic transglycosylase activity
H7678_RS10500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H7678_RS10510	COG0612	Peptidase, M16
H7678_RS10535	COG0516	GMP reductase activity
H7678_RS10535	COG0517	IMP dehydrogenase activity
H7678_RS10545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H7678_RS10550	COG0488	(ABC) transporter
H7678_RS10585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain