locus-tag	class	description
HG697_RS00010	COG0592	DNA-directed DNA polymerase activity
HG697_RS00025	COG0012	GTP binding
HG697_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG697_RS00040	COG2244	polysaccharide biosynthetic process
HG697_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HG697_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG697_RS00075	COG0531	amino acid
HG697_RS00260	COG3942	CHAP domain
HG697_RS00280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG697_RS00285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HG697_RS00290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG697_RS00300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG697_RS00305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG697_RS00320	COG3942	CHAP domain
HG697_RS00325	COG0151	Belongs to the GarS family
HG697_RS00330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HG697_RS00350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG697_RS00365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG697_RS00380	COG1012	belongs to the aldehyde dehydrogenase family
HG697_RS00380	COG1454	alcohol dehydrogenase
HG697_RS00385	COG1064	alcohol dehydrogenase
HG697_RS00390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HG697_RS00405	COG0051	transcription antitermination factor activity, RNA binding
HG697_RS00505	COG0200	Binds to the 23S rRNA
HG697_RS00510	COG0201	protein transport
HG697_RS00530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG697_RS00645	COG0582	viral genome integration into host DNA
HG697_RS00670	COG1395	domain, Protein
HG697_RS00695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HG697_RS00705	COG1252	NADH dehydrogenase
HG697_RS00710	COG1271	oxidase subunit
HG697_RS00715	COG1294	oxidase, subunit
HG697_RS00720	COG4988	ABC transporter
HG697_RS00725	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HG697_RS00730	COG0142	geranyltranstransferase activity
HG697_RS00745	COG1121	(ABC) transporter
HG697_RS00750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG697_RS00760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG697_RS00760	COG4499	WXG100 protein secretion system (Wss), protein YukC
HG697_RS00780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HG697_RS00785	COG1459	type II secretion system
HG697_RS00790	COG4537	Required for transformation and DNA binding
HG697_RS00795	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HG697_RS00805	COG1396	sequence-specific DNA binding
HG697_RS00810	COG1396	sequence-specific DNA binding
HG697_RS01035	COG4824	toxin secretion phage lysis holin
HG697_RS01090	COG1266	CAAX protease self-immunity
HG697_RS01100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HG697_RS01105	COG1363	Peptidase, m42
HG697_RS01115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG697_RS01120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG697_RS01130	COG1428	Deoxynucleoside kinase
HG697_RS01135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG697_RS01190	COG0251	oxidation-reduction process
HG697_RS01215	COG1744	ABC transporter substrate-binding protein PnrA-like
HG697_RS01220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HG697_RS01225	COG1349	DNA-binding transcription factor activity
HG697_RS01230	COG2390	Transcriptional regulator
HG697_RS01235	COG1447	Phosphotransferase system cellobiose-specific component IIA
HG697_RS01240	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HG697_RS01245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HG697_RS01250	COG1882	Formate acetyltransferase
HG697_RS01270	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG697_RS01295	COG3655	Transcriptional regulator
HG697_RS01360	COG1132	(ABC) transporter
HG697_RS01430	COG1122	ATPase activity
HG697_RS01455	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG697_RS01460	COG0512	Glutamine amidotransferase of anthranilate synthase
HG697_RS01465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG697_RS01480	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HG697_RS01485	COG1609	Transcriptional regulator
HG697_RS01490	COG2190	(PTS) system
HG697_RS01490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG697_RS01490	COG1263	PTS System
HG697_RS01505	COG1363	Peptidase, m42
HG697_RS01555	COG3842	ATPase activity
HG697_RS01565	COG1523	belongs to the glycosyl hydrolase 13 family
HG697_RS01580	COG1862	Preprotein translocase
HG697_RS01590	COG4589	Belongs to the CDS family
HG697_RS01615	COG1846	Transcriptional regulator
HG697_RS01645	COG3711	transcriptional antiterminator
HG697_RS01655	COG3037	sugar-specific permease SgaT UlaA
HG697_RS01660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG697_RS01675	COG1045	serine acetyltransferase
HG697_RS01690	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HG697_RS01710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG697_RS01730	COG1476	TRANSCRIPTIONal
HG697_RS01745	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HG697_RS01755	COG4974	Belongs to the 'phage' integrase family
HG697_RS01855	COG2274	protein secretion by the type I secretion system
HG697_RS01860	COG1136	(ABC) transporter
HG697_RS01865	COG0577	efflux transmembrane transporter activity
HG697_RS01910	COG3775	system Galactitol-specific IIC component
HG697_RS01915	COG3414	Phosphotransferase system galactitol-specific IIB component
HG697_RS01935	COG0561	phosphatase activity
HG697_RS01980	COG0527	aspartate kinase activity
HG697_RS01990	COG0351	phosphomethylpyrimidine kinase
HG697_RS01995	COG4720	Psort location CytoplasmicMembrane, score
HG697_RS02005	COG0668	transmembrane transport
HG697_RS02015	COG0366	Alpha amylase catalytic
HG697_RS02025	COG3343	RNA polymerase activity
HG697_RS02040	COG3279	Response regulator of the LytR AlgR family
HG697_RS02050	COG1346	cytolysis
HG697_RS02100	COG0765	amino acid transport
HG697_RS02120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG697_RS02130	COG0719	Fe-S assembly protein
HG697_RS02135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG697_RS02150	COG1686	Belongs to the peptidase S11 family
HG697_RS02155	COG1686	Belongs to the peptidase S11 family
HG697_RS02160	COG4166	transmembrane transport
HG697_RS02165	COG0601	transmembrane transport
HG697_RS02170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG697_RS02175	COG0444	Belongs to the ABC transporter superfamily
HG697_RS02230	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HG697_RS02235	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HG697_RS02240	COG1534	Rna-binding protein
HG697_RS02250	COG1713	HD superfamily hydrolase involved in NAD metabolism
HG697_RS02260	COG0799	negative regulation of ribosome biogenesis
HG697_RS02265	COG2226	methyltransferase
HG697_RS02275	COG0789	Transcriptional regulator
HG697_RS02290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG697_RS02300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG697_RS02310	COG1464	Belongs to the NlpA lipoprotein family
HG697_RS02315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG697_RS02330	COG1114	Component of the transport system for branched-chain amino acids
HG697_RS02340	COG0569	domain protein
HG697_RS02345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HG697_RS02355	COG1704	LemA family
HG697_RS02370	COG0745	RESPONSE REGULATOR receiver
HG697_RS02375	COG5002	protein histidine kinase activity
HG697_RS02380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG697_RS02390	COG1484	DNA-dependent DNA replication
HG697_RS02400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HG697_RS02420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HG697_RS02435	COG1254	Belongs to the acylphosphatase family
HG697_RS02440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HG697_RS02475	COG4175	Glycine betaine
HG697_RS02495	COG1187	pseudouridine synthase activity
HG697_RS02510	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HG697_RS02515	COG0671	phosphoesterase, PA-phosphatase related
HG697_RS02520	COG1242	4 iron, 4 sulfur cluster binding
HG697_RS02525	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HG697_RS02530	COG1253	flavin adenine dinucleotide binding
HG697_RS02535	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HG697_RS02550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG697_RS02555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG697_RS02560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HG697_RS02565	COG1120	ATPase activity
HG697_RS02575	COG2244	polysaccharide biosynthetic process
HG697_RS02615	COG0559	Belongs to the binding-protein-dependent transport system permease family
HG697_RS02625	COG0411	ABC transporter
HG697_RS02635	COG0517	IMP dehydrogenase activity
HG697_RS02645	COG0470	DNA polymerase III
HG697_RS02650	COG1774	PSP1 C-terminal conserved region
HG697_RS02675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HG697_RS02690	COG1393	Belongs to the ArsC family
HG697_RS02705	COG0708	Exodeoxyribonuclease III
HG697_RS02715	COG1620	l-lactate permease
HG697_RS02720	COG1304	FMN binding
HG697_RS02760	COG1114	Component of the transport system for branched-chain amino acids
HG697_RS02775	COG1028	Short-chain dehydrogenase reductase Sdr
HG697_RS02790	COG0673	inositol 2-dehydrogenase activity
HG697_RS02815	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG697_RS02840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HG697_RS02910	COG1702	phosphate starvation-inducible protein PhoH
HG697_RS02915	COG1573	uracil-dna glycosylase
HG697_RS02925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HG697_RS02935	COG2274	protein secretion by the type I secretion system
HG697_RS02965	COG3279	Response regulator of the LytR AlgR family
HG697_RS03030	COG1396	sequence-specific DNA binding
HG697_RS03045	COG1131	(ABC) transporter
HG697_RS03055	COG0433	COG0433 Predicted ATPase
HG697_RS03060	COG2814	Major facilitator Superfamily
HG697_RS03075	COG0557	exoribonuclease II activity
HG697_RS03080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG697_RS03090	COG0463	Glycosyl transferase, family 2
HG697_RS03100	COG0346	lactoylglutathione lyase activity
HG697_RS03105	COG0778	Nitroreductase
HG697_RS03110	COG0006	proline dipeptidase activity
HG697_RS03115	COG1609	Transcriptional regulator
HG697_RS03130	COG0438	transferase activity, transferring glycosyl groups
HG697_RS03140	COG4555	ABC transporter
HG697_RS03155	COG2376	Dihydroxyacetone kinase
HG697_RS03165	COG2376	Dihydroxyacetone kinase
HG697_RS03170	COG1461	Dihydroxyacetone kinase
HG697_RS03175	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HG697_RS03180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG697_RS03190	COG0183	Belongs to the thiolase family
HG697_RS03205	COG0765	amino acid transport
HG697_RS03210	COG0765	amino acid transport
HG697_RS03215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG697_RS03225	COG0745	RESPONSE REGULATOR receiver
HG697_RS03230	COG5002	protein histidine kinase activity
HG697_RS03235	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HG697_RS03245	COG1196	nuclear chromosome segregation
HG697_RS03265	COG0561	phosphatase activity
HG697_RS03270	COG0561	phosphatase activity
HG697_RS03275	COG0552	protein localization to endoplasmic reticulum
HG697_RS03280	COG0477	Major facilitator Superfamily
HG697_RS03285	COG3711	transcriptional antiterminator
HG697_RS03290	COG1263	PTS System
HG697_RS03290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG697_RS03290	COG2190	(PTS) system
HG697_RS03300	COG3689	TIGRFAM TIGR03943 family protein
HG697_RS03305	COG0701	Predicted permease
HG697_RS03320	COG0745	RESPONSE REGULATOR receiver
HG697_RS03325	COG5002	protein histidine kinase activity
HG697_RS03330	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HG697_RS03335	COG0573	inorganic phosphate transmembrane transporter activity
HG697_RS03345	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG697_RS03350	COG0704	Plays a role in the regulation of phosphate uptake
HG697_RS03365	COG2183	response to ionizing radiation
HG697_RS03415	COG4443	Transcriptional Coactivator p15 (PC4)
HG697_RS03455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HG697_RS03490	COG0386	Belongs to the glutathione peroxidase family
HG697_RS03495	COG1164	Oligoendopeptidase f
HG697_RS03505	COG0772	Belongs to the SEDS family
HG697_RS03510	COG1191	sigma factor activity
HG697_RS03585	COG1078	dGTPase activity
HG697_RS03605	COG1609	Transcriptional regulator
HG697_RS03615	COG3716	PTS system mannose fructose sorbose family IID component
HG697_RS03620	COG3715	PTS system
HG697_RS03625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG697_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
HG697_RS03660	COG5492	domain, Protein
HG697_RS03680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG697_RS03685	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HG697_RS03690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HG697_RS03700	COG2884	Cell division ATP-binding protein ftsE
HG697_RS03705	COG2177	Part of the ABC transporter FtsEX involved in
HG697_RS03715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HG697_RS03715	COG1199	ATP-dependent helicase activity
HG697_RS03720	COG0436	Aminotransferase
HG697_RS03725	COG0017	Asparaginyl-tRNA synthetase
HG697_RS03760	COG2188	Transcriptional regulator
HG697_RS03765	COG2222	sugar isomerase
HG697_RS03785	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG697_RS03785	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG697_RS03790	COG3715	PTS system
HG697_RS03795	COG3716	PTS system mannose fructose sorbose family IID component
HG697_RS03815	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HG697_RS03820	COG2153	protein acetylation
HG697_RS03825	COG0625	glutathione transferase activity
HG697_RS03835	COG0716	FMN binding
HG697_RS03845	COG0038	chloride channel
HG697_RS03860	COG0772	Belongs to the SEDS family
HG697_RS03880	COG0560	Phosphoserine phosphatase
HG697_RS03925	COG1131	(ABC) transporter
HG697_RS03945	COG4708	membrane
HG697_RS03955	COG1597	lipid kinase activity
HG697_RS03960	COG1523	belongs to the glycosyl hydrolase 13 family
HG697_RS03965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HG697_RS03970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG697_RS03975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HG697_RS04065	COG0577	efflux transmembrane transporter activity
HG697_RS04075	COG2321	neutral zinc metallopeptidase
HG697_RS04090	COG0436	Aminotransferase
HG697_RS04105	COG1970	mechanosensitive ion channel activity
HG697_RS04110	COG0358	DNA primase activity
HG697_RS04115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG697_RS04120	COG2151	metal-sulfur cluster biosynthetic enzyme
HG697_RS04135	COG1216	Glycosyl transferase, family 2
HG697_RS04135	COG1442	glycosyl transferase family 8
HG697_RS04165	COG1216	Glycosyl transferase, family 2
HG697_RS04225	COG1368	sulfuric ester hydrolase activity
HG697_RS04230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HG697_RS04250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG697_RS04255	COG0285	dihydrofolate synthase activity
HG697_RS04265	COG1104	cysteine desulfurase activity
HG697_RS04295	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG697_RS04300	COG0583	DNA-binding transcription factor activity
HG697_RS04310	COG0564	pseudouridine synthase activity
HG697_RS04345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG697_RS04350	COG1136	(ABC) transporter
HG697_RS04355	COG0577	efflux transmembrane transporter activity
HG697_RS04365	COG0584	glycerophosphoryl diester phosphodiesterase
HG697_RS04375	COG1837	Belongs to the UPF0109 family
HG697_RS04425	COG1349	DNA-binding transcription factor activity
HG697_RS04430	COG1105	Belongs to the carbohydrate kinase PfkB family
HG697_RS04435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HG697_RS04435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HG697_RS04435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG697_RS04440	COG1388	LysM domain
HG697_RS04440	COG1705	Flagellar rod assembly protein muramidase FlgJ
HG697_RS04445	COG1388	LysM domain
HG697_RS04445	COG1705	Flagellar rod assembly protein muramidase FlgJ
HG697_RS04470	COG0488	(ABC) transporter
HG697_RS04480	COG1132	(ABC) transporter
HG697_RS04485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG697_RS04490	COG0242	peptide deformylase activity
HG697_RS04495	COG0737	Belongs to the 5'-nucleotidase family
HG697_RS04540	COG1686	Belongs to the peptidase S11 family
HG697_RS04545	COG0726	polysaccharide deacetylase
HG697_RS04560	COG0285	dihydrofolate synthase activity
HG697_RS04565	COG0302	gtp cyclohydrolase
HG697_RS04595	COG1176	ABC-type spermidine putrescine transport system, permease component I
HG697_RS04600	COG1177	transmembrane transport
HG697_RS04610	COG4565	transcriptional regulatory protein
HG697_RS04615	COG3290	protein histidine kinase activity
HG697_RS04620	COG3493	citrate carrier protein
HG697_RS04630	COG0038	chloride channel
HG697_RS04635	COG4977	sequence-specific DNA binding
HG697_RS04635	COG1917	Cupin 2, conserved barrel domain protein
HG697_RS04645	COG0628	permease
HG697_RS04655	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HG697_RS04675	COG1104	cysteine desulfurase activity
HG697_RS04690	COG2357	RelA SpoT domain protein
HG697_RS04700	COG0564	pseudouridine synthase activity
HG697_RS04705	COG0280	phosphate acetyltransferase
HG697_RS04710	COG4221	oxidoreductase activity
HG697_RS04725	COG1174	glycine betaine transport
HG697_RS04740	COG2233	PERMEase
HG697_RS04750	COG1942	4-Oxalocrotonate Tautomerase
HG697_RS04765	COG2890	protein-(glutamine-N5) methyltransferase activity
HG697_RS04770	COG0009	L-threonylcarbamoyladenylate synthase
HG697_RS04795	COG1132	(ABC) transporter
HG697_RS04800	COG1132	(ABC) transporter
HG697_RS04810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HG697_RS04825	COG3764	Sortase (surface protein transpeptidase)
HG697_RS04830	COG0346	lactoylglutathione lyase activity
HG697_RS04865	COG1136	(ABC) transporter
HG697_RS04870	COG0577	efflux transmembrane transporter activity
HG697_RS04875	COG0745	RESPONSE REGULATOR receiver
HG697_RS04880	COG2205	protein histidine kinase activity
HG697_RS04885	COG3942	CHAP domain
HG697_RS04885	COG1705	Flagellar rod assembly protein muramidase FlgJ
HG697_RS04910	COG0803	Belongs to the bacterial solute-binding protein 9 family
HG697_RS04930	COG1122	ATPase activity
HG697_RS04940	COG0601	transmembrane transport
HG697_RS04975	COG2188	Transcriptional regulator
HG697_RS04985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HG697_RS05005	COG0673	inositol 2-dehydrogenase activity
HG697_RS05010	COG5002	protein histidine kinase activity
HG697_RS05015	COG0662	Cupin 2, conserved barrel domain protein
HG697_RS05050	COG5002	protein histidine kinase activity
HG697_RS05055	COG0745	RESPONSE REGULATOR receiver
HG697_RS05060	COG0577	efflux transmembrane transporter activity
HG697_RS05065	COG1136	(ABC) transporter
HG697_RS05080	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HG697_RS05115	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HG697_RS05120	COG0511	ligase activity, forming carbon-carbon bonds
HG697_RS05130	COG2851	Citrate transporter
HG697_RS05150	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HG697_RS05155	COG0511	ligase activity, forming carbon-carbon bonds
HG697_RS05200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG697_RS05205	COG0758	DNA mediated transformation
HG697_RS05225	COG1396	sequence-specific DNA binding
HG697_RS05235	COG1272	protein, Hemolysin III
HG697_RS05255	COG0488	(ABC) transporter
HG697_RS05275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG697_RS05280	COG1328	CTP reductase activity
HG697_RS05280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG697_RS05285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG697_RS05290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG697_RS05345	COG0095	Lipoate-protein ligase
HG697_RS05355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HG697_RS05360	COG4684	Psort location CytoplasmicMembrane, score
HG697_RS05365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG697_RS05385	COG1744	ABC transporter substrate-binding protein PnrA-like
HG697_RS05400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HG697_RS05405	COG2813	Specifically methylates the guanine in position
HG697_RS05420	COG5002	protein histidine kinase activity
HG697_RS05425	COG0745	RESPONSE REGULATOR receiver
HG697_RS05435	COG0704	Plays a role in the regulation of phosphate uptake
HG697_RS05450	COG0581	inorganic phosphate transmembrane transporter activity
HG697_RS05455	COG0573	inorganic phosphate transmembrane transporter activity
HG697_RS05465	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HG697_RS05465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG697_RS05470	COG0483	inositol monophosphate 1-phosphatase activity
HG697_RS05485	COG0196	riboflavin kinase activity
HG697_RS05515	COG1136	(ABC) transporter
HG697_RS05515	COG4591	ABC-type transport system involved in lipoprotein release permease component
HG697_RS05555	COG2261	transglycosylase associated protein
HG697_RS05570	COG1115	amino acid carrier protein
HG697_RS05575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HG697_RS05585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG697_RS05590	COG1126	abc transporter atp-binding protein
HG697_RS05595	COG0765	amino acid transport
HG697_RS05600	COG2824	Alkylphosphonate utilization operon protein PhnA
HG697_RS05615	COG0469	pyruvate kinase activity
HG697_RS05630	COG1725	Transcriptional regulator
HG697_RS05635	COG1131	(ABC) transporter
HG697_RS05645	COG0398	Pfam SNARE associated Golgi protein
HG697_RS05670	COG0539	negative regulation of cytoplasmic translation
HG697_RS05690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG697_RS05710	COG0187	DNA topoisomerase II activity
HG697_RS05730	COG0765	amino acid transport
HG697_RS05745	COG2801	Transposase and inactivated derivatives
HG697_RS05785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG697_RS05810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG697_RS05820	COG0028	Belongs to the TPP enzyme family
HG697_RS05825	COG0028	Belongs to the TPP enzyme family
HG697_RS05835	COG0028	Belongs to the TPP enzyme family
HG697_RS05850	COG1012	belongs to the aldehyde dehydrogenase family
HG697_RS05855	COG1011	Hydrolase
HG697_RS05865	COG0701	Predicted permease
HG697_RS05880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG697_RS05895	COG4753	response regulator
HG697_RS05895	COG2207	Transcriptional regulator
HG697_RS05900	COG2972	Histidine kinase
HG697_RS05905	COG3716	PTS system mannose fructose sorbose family IID component
HG697_RS05910	COG3715	PTS system
HG697_RS05970	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HG697_RS05975	COG1518	maintenance of DNA repeat elements
HG697_RS05990	COG0647	UMP catabolic process
HG697_RS06000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG697_RS06020	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HG697_RS06025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG697_RS06030	COG3442	glutamine amidotransferase
HG697_RS06035	COG0095	Lipoate-protein ligase
HG697_RS06045	COG1695	Transcriptional regulator
HG697_RS06055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG697_RS06060	COG0022	dehydrogenase e1 component
HG697_RS06060	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG697_RS06065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HG697_RS06070	COG0488	(ABC) transporter
HG697_RS06090	COG1122	ATPase activity
HG697_RS06120	COG3700	Belongs to the class B bacterial acid phosphatase family
HG697_RS06140	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HG697_RS06145	COG0457	Tetratricopeptide repeat
HG697_RS06150	COG0628	permease
HG697_RS06155	COG1051	belongs to the nudix hydrolase family
HG697_RS06175	COG1088	dTDP-glucose 4,6-dehydratase activity
HG697_RS06185	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HG697_RS06190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG697_RS06205	COG2384	SAM-dependent methyltransferase
HG697_RS06210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG697_RS06225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG697_RS06225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG697_RS06230	COG0300	oxidoreductase activity
HG697_RS06245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HG697_RS06290	COG0431	NADPH-dependent FMN reductase
HG697_RS06295	COG0058	SHG alpha-glucan phosphorylase activity
HG697_RS06300	COG1640	4-alpha-glucanotransferase
HG697_RS06305	COG1609	Transcriptional regulator
HG697_RS06315	COG2182	Extracellular solute-binding protein
HG697_RS06325	COG3833	ABC-type maltose transport systems, permease component
HG697_RS06350	COG0366	Alpha amylase catalytic
HG697_RS06355	COG2182	Extracellular solute-binding protein
HG697_RS06360	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HG697_RS06370	COG1696	Membrane protein involved in D-alanine export
HG697_RS06390	COG0765	amino acid transport
HG697_RS06395	COG1126	abc transporter atp-binding protein
HG697_RS06420	COG2309	aminopeptidase activity
HG697_RS06435	COG1187	pseudouridine synthase activity
HG697_RS06445	COG2814	Major facilitator Superfamily
HG697_RS06455	COG0390	transport system, permease component
HG697_RS06460	COG4619	ABC transporter
HG697_RS06530	COG0534	Mate efflux family protein
HG697_RS06535	COG1129	ABC transporter
HG697_RS06550	COG1132	(ABC) transporter
HG697_RS06560	COG1309	transcriptional regulator
HG697_RS06575	COG4581	dead DEAH box helicase
HG697_RS06615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG697_RS06615	COG0551	DNA topoisomerase type I activity
HG697_RS06690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HG697_RS06720	COG4109	DRTGG domain
HG697_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
HG697_RS06760	COG0800	Aldolase
HG697_RS06765	COG2186	Transcriptional regulator
HG697_RS06770	COG3250	beta-galactosidase activity
HG697_RS06780	COG2211	Major facilitator Superfamily
HG697_RS06800	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HG697_RS06800	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HG697_RS06810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HG697_RS06815	COG1956	GAF domain-containing protein
HG697_RS06835	COG0513	Belongs to the DEAD box helicase family
HG697_RS06840	COG0726	polysaccharide deacetylase
HG697_RS06860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HG697_RS06865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG697_RS06870	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG697_RS06890	COG1476	TRANSCRIPTIONal
HG697_RS06910	COG4122	O-methyltransferase activity
HG697_RS06915	COG2223	nitrite transmembrane transporter activity
HG697_RS06930	COG0431	NADPH-dependent FMN reductase
HG697_RS06950	COG1187	pseudouridine synthase activity
HG697_RS06985	COG2333	competence protein COMEC
HG697_RS06985	COG0658	competence protein
HG697_RS06990	COG1555	photosystem II stabilization
HG697_RS06990	COG1596	polysaccharide export
HG697_RS06995	COG0204	Acyl-transferase
HG697_RS07000	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HG697_RS07015	COG0513	Belongs to the DEAD box helicase family
HG697_RS07020	COG1464	Belongs to the NlpA lipoprotein family
HG697_RS07030	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HG697_RS07050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HG697_RS07065	COG0768	penicillin binding
HG697_RS07070	COG2116	formate transmembrane transporter activity
HG697_RS07080	COG1827	regulation of RNA biosynthetic process
HG697_RS07100	COG2217	Heavy metal translocating P-type atpase
HG697_RS07125	COG2755	lipolytic protein G-D-S-L family
HG697_RS07140	COG0497	DNA recombination
HG697_RS07145	COG1438	arginine binding
HG697_RS07150	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HG697_RS07180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG697_RS07210	COG0765	amino acid transport
HG697_RS07215	COG4703	Protein of unknown function (DUF1797)
HG697_RS07220	COG0542	response to heat
HG697_RS07225	COG1051	belongs to the nudix hydrolase family
HG697_RS07240	COG3599	regulation of cell shape
HG697_RS07260	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG697_RS07270	COG0849	cell division
HG697_RS07305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG697_RS07310	COG1940	carbohydrate kinase activity
HG697_RS07320	COG0783	Belongs to the Dps family
HG697_RS07330	COG1132	(ABC) transporter
HG697_RS07335	COG1132	(ABC) transporter
HG697_RS07345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HG697_RS07350	COG4470	Protein conserved in bacteria
HG697_RS07365	COG1879	ABC-type sugar transport system periplasmic component
HG697_RS07370	COG1172	Belongs to the binding-protein-dependent transport system permease family
HG697_RS07380	COG1869	D-ribose catabolic process
HG697_RS07385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG697_RS07390	COG1609	Transcriptional regulator
HG697_RS07395	COG3480	Lon protease (S16) C-terminal proteolytic domain
HG697_RS07405	COG0742	ribosomal rna small subunit methyltransferase
HG697_RS07415	COG0549	Belongs to the carbamate kinase family
HG697_RS07425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG697_RS07430	COG1288	antiporter activity
HG697_RS07440	COG0454	-acetyltransferase
HG697_RS07445	COG2235	arginine
HG697_RS07450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG697_RS07470	COG2972	Histidine kinase
HG697_RS07485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG697_RS07490	COG0785	Cytochrome C biogenesis protein
HG697_RS07500	COG0673	inositol 2-dehydrogenase activity
HG697_RS07505	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HG697_RS07510	COG1518	maintenance of DNA repeat elements
HG697_RS07540	COG5433	transposase activity
HG697_RS07560	COG0346	lactoylglutathione lyase activity
HG697_RS07635	COG0433	COG0433 Predicted ATPase
HG697_RS07670	COG3620	sequence-specific DNA binding
HG697_RS07685	COG1674	ftsk spoiiie
HG697_RS07765	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HG697_RS07765	COG1605	Chorismate mutase
HG697_RS07800	COG3250	beta-galactosidase activity
HG697_RS07805	COG4753	response regulator
HG697_RS07805	COG2207	Transcriptional regulator
HG697_RS07810	COG2972	Histidine kinase
HG697_RS07825	COG0395	ABC-type sugar transport system, permease component
HG697_RS07830	COG1175	transmembrane transport
HG697_RS07835	COG1940	carbohydrate kinase activity
HG697_RS07850	COG2723	6-phospho-beta-galactosidase activity
HG697_RS07855	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HG697_RS07870	COG0383	alpha-mannosidase activity
HG697_RS07890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG697_RS07900	COG2070	2-Nitropropane dioxygenase
HG697_RS08010	COG1040	competence protein
HG697_RS08015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HG697_RS08020	COG1739	Uncharacterized protein family UPF0029
HG697_RS08030	COG1098	S1 RNA binding domain
HG697_RS08040	COG2197	response regulator
HG697_RS08045	COG4585	Histidine kinase
HG697_RS08055	COG2815	serine threonine protein kinase
HG697_RS08055	COG0515	serine threonine protein kinase
HG697_RS08065	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG697_RS08065	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG697_RS08075	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HG697_RS08095	COG0583	DNA-binding transcription factor activity
HG697_RS08100	COG0183	Belongs to the thiolase family
HG697_RS08105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HG697_RS08135	COG0116	Belongs to the methyltransferase superfamily
HG697_RS08160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG697_RS08165	COG3579	cysteine-type endopeptidase activity
HG697_RS08175	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HG697_RS08180	COG1113	amino acid transport
HG697_RS08185	COG0492	ferredoxin-NADP+ reductase activity
HG697_RS08195	COG1126	abc transporter atp-binding protein
HG697_RS08200	COG0765	amino acid transport
HG697_RS08210	COG0513	Belongs to the DEAD box helicase family
HG697_RS08220	COG0768	penicillin binding
HG697_RS08250	COG1131	(ABC) transporter
HG697_RS08275	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG697_RS08280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG697_RS08315	COG1755	Isoprenylcysteine carboxyl methyltransferase
HG697_RS08320	COG0656	L-ascorbic acid biosynthetic process
HG697_RS08330	COG1283	sodium-dependent phosphate transmembrane transporter activity
HG697_RS08350	COG0561	phosphatase activity
HG697_RS08355	COG2860	membrane
HG697_RS08365	COG1105	Belongs to the carbohydrate kinase PfkB family
HG697_RS08395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG697_RS08415	COG2217	Heavy metal translocating P-type atpase
HG697_RS08445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HG697_RS08450	COG0195	Participates in both transcription termination and antitermination
HG697_RS08475	COG4473	ABC transporter
HG697_RS08480	COG1131	(ABC) transporter
HG697_RS08485	COG0537	adenosine 5'-monophosphoramidase activity
HG697_RS08495	COG1316	TRANSCRIPTIONal
HG697_RS08500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG697_RS08505	COG0802	atpase or kinase
HG697_RS08510	COG2252	PERMEase
HG697_RS08515	COG0561	phosphatase activity
HG697_RS08525	COG3715	PTS system
HG697_RS08530	COG3716	PTS system mannose fructose sorbose family IID component
HG697_RS08560	COG0439	Biotin carboxylase
HG697_RS08575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG697_RS08580	COG1028	Short-chain dehydrogenase reductase Sdr
HG697_RS08585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG697_RS08590	COG2070	2-Nitropropane dioxygenase
HG697_RS08610	COG1024	Enoyl-CoA hydratase
HG697_RS08615	COG0484	heat shock protein binding
HG697_RS08635	COG1420	regulation of RNA biosynthetic process
HG697_RS08655	COG0588	phosphoglycerate mutase activity
HG697_RS08660	COG2261	transglycosylase associated protein
HG697_RS08685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG697_RS08685	COG0574	Belongs to the PEP-utilizing enzyme family
HG697_RS08690	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HG697_RS08695	COG0517	IMP dehydrogenase activity
HG697_RS08705	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG697_RS08715	COG1937	Protein conserved in bacteria
HG697_RS08720	COG1335	isochorismatase
HG697_RS08730	COG0436	Aminotransferase
HG697_RS08740	COG0561	phosphatase activity
HG697_RS08745	COG0252	asparaginase activity
HG697_RS08750	COG4989	oxidoreductase activity
HG697_RS08755	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HG697_RS08760	COG1129	ABC transporter
HG697_RS08775	COG1132	(ABC) transporter
HG697_RS08780	COG4988	ABC transporter
HG697_RS08785	COG1120	ATPase activity
HG697_RS08810	COG1388	LysM domain
HG697_RS08810	COG3942	CHAP domain
HG697_RS08830	COG1482	cell wall glycoprotein biosynthetic process
HG697_RS08835	COG1940	carbohydrate kinase activity
HG697_RS08840	COG2190	(PTS) system
HG697_RS08840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG697_RS08840	COG1263	PTS System
HG697_RS08845	COG1621	beta-fructofuranosidase activity
HG697_RS08850	COG1609	Transcriptional regulator
HG697_RS08870	COG2131	deaminase
HG697_RS08875	COG0006	proline dipeptidase activity
HG697_RS08915	COG1194	a g-specific adenine glycosylase
HG697_RS08925	COG3118	belongs to the thioredoxin family
HG697_RS08930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG697_RS08955	COG0681	Belongs to the peptidase S26 family
HG697_RS08960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HG697_RS08975	COG1882	Formate acetyltransferase
HG697_RS08980	COG2153	protein acetylation
HG697_RS08990	COG1653	transport
HG697_RS09000	COG0395	ABC-type sugar transport system, permease component
HG697_RS09005	COG4209	transmembrane transport
HG697_RS09015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HG697_RS09030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HG697_RS09060	COG0789	Transcriptional regulator
HG697_RS09075	COG2081	HI0933 family
HG697_RS09110	COG1214	PFAM Peptidase M22, glycoprotease
HG697_RS09125	COG4608	Belongs to the ABC transporter superfamily
HG697_RS09130	COG0444	Belongs to the ABC transporter superfamily
HG697_RS09135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HG697_RS09140	COG0601	transmembrane transport
HG697_RS09145	COG4166	transmembrane transport
HG697_RS09150	COG0174	glutamine synthetase
HG697_RS09155	COG0789	Transcriptional regulator
HG697_RS09170	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HG697_RS09200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG697_RS09215	COG1564	THIamine pyrophosphokinase
HG697_RS09240	COG0084	hydrolase, TatD family'
HG697_RS09245	COG1335	isochorismatase
HG697_RS09260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG697_RS09275	COG0395	ABC-type sugar transport system, permease component
HG697_RS09280	COG1175	transmembrane transport
HG697_RS09305	COG1847	R3H domain protein
HG697_RS09370	COG0756	dUTP diphosphatase activity
HG697_RS09380	COG1132	(ABC) transporter
HG697_RS09385	COG1132	(ABC) transporter
HG697_RS09400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HG697_RS09410	COG0457	Tetratricopeptide repeat
HG697_RS09410	COG0705	Rhomboid family
HG697_RS09415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HG697_RS09455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG697_RS09485	COG1234	tRNA 3'-trailer cleavage
HG697_RS09490	COG1268	BioY protein
HG697_RS09515	COG1832	CoA-binding protein
HG697_RS09520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG697_RS09520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG697_RS09530	COG4175	Glycine betaine
HG697_RS09530	COG3448	diguanylate cyclase activity
HG697_RS09535	COG1597	lipid kinase activity
HG697_RS09555	COG3623	hexulose-6-phosphate isomerase
HG697_RS09660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG697_RS09675	COG0564	pseudouridine synthase activity
HG697_RS09705	COG0542	response to heat
HG697_RS09710	COG4463	regulation of RNA biosynthetic process
HG697_RS09740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HG697_RS09765	COG0450	alkyl hydroperoxide reductase
HG697_RS09780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HG697_RS09790	COG3404	Formiminotransferase-cyclodeaminase
HG697_RS09805	COG0531	amino acid
HG697_RS09835	COG3590	peptidase
HG697_RS09840	COG0366	Alpha amylase catalytic
HG697_RS09845	COG1263	PTS System
HG697_RS09845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG697_RS09850	COG2188	Transcriptional regulator
HG697_RS09870	COG0602	queuosine metabolic process
HG697_RS09910	COG4472	Bacterial protein of unknown function (DUF965)
HG697_RS09915	COG1393	Belongs to the ArsC family
HG697_RS09940	COG0519	Catalyzes the synthesis of GMP from XMP
HG697_RS09950	COG2814	Major facilitator Superfamily
HG697_RS09985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HG697_RS09990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HG697_RS09995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HG697_RS10080	COG1511	domain protein
HG697_RS10220	COG0582	viral genome integration into host DNA
HG697_RS10225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG697_RS10230	COG5433	transposase activity
HG697_RS10245	COG0305	Participates in initiation and elongation during chromosome replication
HG697_RS10270	COG2095	MarC family integral membrane protein
HG697_RS10280	COG1760	l-serine dehydratase
HG697_RS10285	COG1760	l-serine dehydratase
HG697_RS10295	COG0741	lytic transglycosylase activity
HG697_RS10315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG697_RS10325	COG0612	Peptidase, M16
HG697_RS10350	COG0517	IMP dehydrogenase activity
HG697_RS10350	COG0516	GMP reductase activity
HG697_RS10360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HG697_RS10365	COG0488	(ABC) transporter
HG697_RS10400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain