locus-tag	class	description
HHM65_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HHM65_RS00025	ENOG4105C3G	gtp-binding protein
HHM65_RS00035	ENOG4108JA2	transcriptioN-repair coupling factor
HHM65_RS00045	ENOG41082I2	s4 domain protein
HHM65_RS00070	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HHM65_RS00075	ENOG4105CUB	amino acid
HHM65_RS00260	ENOG41068JE	domain protein
HHM65_RS00280	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HHM65_RS00285	ENOG4105C8V	SAICAR synthetase
HHM65_RS00290	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HHM65_RS00295	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HHM65_RS00300	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HHM65_RS00305	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HHM65_RS00325	ENOG4105C12	Phosphoribosylglycinamide synthetase
HHM65_RS00330	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HHM65_RS00335	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HHM65_RS00350	ENOG4105C83	adenylosuccinate lyase
HHM65_RS00365	ENOG4105KJF	protein tyrosine phosphatase
HHM65_RS00380	ENOG4105C0A	alcohol dehydrogenase
HHM65_RS00390	ENOG4107QID	Threonine synthase
HHM65_RS00405	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HHM65_RS00505	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HHM65_RS00510	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HHM65_RS00530	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHM65_RS00645	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
HHM65_RS00670	ENOG41067QW	Transcriptional regulator
HHM65_RS00695	ENOG4108XXK	NUDIX hydrolase
HHM65_RS00705	ENOG4105CEP	NADH dehydrogenase
HHM65_RS00710	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HHM65_RS00715	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HHM65_RS00720	ENOG4108JJ9	ABC, transporter
HHM65_RS00725	ENOG4108JJ8	(ABC) transporter
HHM65_RS00730	ENOG4105EAH	synthase
HHM65_RS00745	ENOG4105FDK	ABC transporter
HHM65_RS00760	ENOG4105BZ4	penicillin-binding protein
HHM65_RS00790	ENOG4106855	Competence protein
HHM65_RS00830	ENOG4108TYN	CAAX amino terminal protease family protein
HHM65_RS00840	ENOG4105II7	pyrroline-5-carboxylate reductase
HHM65_RS00845	ENOG4105CN9	Peptidase m42 family protein
HHM65_RS00860	ENOG4108VDD	TRNA binding domain protein
HHM65_RS00870	ENOG4105ZMH	deoxynucleoside kinase
HHM65_RS00875	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HHM65_RS00930	ENOG4105KME	endoribonuclease L-psp
HHM65_RS00955	ENOG4105DIH	basic membrane
HHM65_RS00960	ENOG4105F1A	Pyruvate formate-lyase
HHM65_RS00965	ENOG4105N2W	Transcriptional regulator
HHM65_RS00970	ENOG4107RHR	regulatoR
HHM65_RS00975	ENOG4105VCP	PTS System
HHM65_RS00980	ENOG4105VZJ	PTS System
HHM65_RS00985	ENOG4105CK1	PTS System
HHM65_RS01010	ENOG4108W5N	phosphatidylglycerophosphatase a
HHM65_RS01035	ENOG4105VMP	Transcriptional regulator
HHM65_RS01050	ENOG4105C5H	ABC transporter
HHM65_RS01100	ENOG4105BZ1	(ABC) transporter
HHM65_RS01110	ENOG41075D4	Aminoglycoside 6-adenylyltransferase
HHM65_RS01170	ENOG4108JJB	ABC transporter
HHM65_RS01195	ENOG4105D1H	recombination factor protein RarA
HHM65_RS01200	ENOG4105DDQ	anthranilate synthase
HHM65_RS01205	ENOG4105CRQ	synthase (Component I)
HHM65_RS01210	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HHM65_RS01240	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HHM65_RS01245	ENOG4105FKQ	transcriptional regulator
HHM65_RS01250	ENOG4105CI1	PTS System
HHM65_RS01265	ENOG4105DER	m42 family
HHM65_RS01315	ENOG4108IJ9	(ABC) transporter
HHM65_RS01325	ENOG4108IUM	Glycogen debranching enzyme
HHM65_RS01340	ENOG4105VIE	preprotein translocase, subunit YajC
HHM65_RS01350	ENOG4105KNE	Phosphatidate cytidylyltransferase
HHM65_RS01405	ENOG4105ETD	TRANSCRIPTIONal
HHM65_RS01415	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
HHM65_RS01420	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HHM65_RS01435	ENOG4105D7W	serine acetyltransferase
HHM65_RS01450	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HHM65_RS01470	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HHM65_RS01480	ENOG4105EPR	degv family
HHM65_RS01490	ENOG4105VZ8	Transcriptional regulator
HHM65_RS01505	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HHM65_RS01555	ENOG4108JJA	ABC, transporter
HHM65_RS01575	ENOG4107ZHV	Transcriptional regulator
HHM65_RS01610	ENOG4105DT3	PTS system, galactitol-specific IIc component
HHM65_RS01615	ENOG4105K18	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)
HHM65_RS01635	ENOG410667J	hydrolase
HHM65_RS01680	ENOG4105CFH	Aspartokinase
HHM65_RS01690	ENOG4105DWF	phosphomethylpyrimidine kinase
HHM65_RS01695	ENOG4105PUK	Membrane
HHM65_RS01705	ENOG4105D8X	mechanosensitive ion channel
HHM65_RS01725	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
HHM65_RS01740	ENOG4105DY9	regulatoR
HHM65_RS01750	ENOG41067MG	lrgb family
HHM65_RS01765	ENOG4105D2N	Aldolase
HHM65_RS01795	ENOG4108JEH	abc transporter atp-binding protein
HHM65_RS01800	ENOG4105E5Q	amino acid AbC transporter
HHM65_RS01820	ENOG4105ESV	Glycosyl transferase, family 4
HHM65_RS01830	ENOG4105JRK	feS assembly protein SufD
HHM65_RS01835	ENOG4105C9B	Cysteine desulfurase
HHM65_RS01840	ENOG4108UNV	SUF system FeS assembly protein, NifU family
HHM65_RS01860	ENOG4105DIB	Oligopeptide-binding protein
HHM65_RS01865	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HHM65_RS01870	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HHM65_RS01875	ENOG4105C3U	ABC transporter
HHM65_RS01880	ENOG4108JQ7	(ABC) transporter
HHM65_RS01930	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
HHM65_RS01935	ENOG4105CQW	ribosome biogenesis GTPase YqeH
HHM65_RS01940	ENOG410812S	Rna-binding protein
HHM65_RS01950	ENOG4108WF2	Metal Dependent Phosphohydrolase
HHM65_RS01960	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HHM65_RS01965	ENOG4105DXX	methyltransferase
HHM65_RS01975	ENOG4107TXC	Transcriptional regulator
HHM65_RS01990	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HHM65_RS02005	ENOG4105D01	(LipO)protein
HHM65_RS02010	ENOG4105D01	(LipO)protein
HHM65_RS02015	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HHM65_RS02025	ENOG4108UMI	ABC transporter, permease
HHM65_RS02030	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HHM65_RS02040	ENOG4107ZYR	domain protein
HHM65_RS02055	ENOG4108V0P	LemA family
HHM65_RS02070	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HHM65_RS02075	ENOG4105GR3	Histidine kinase
HHM65_RS02080	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HHM65_RS02100	ENOG4105C0D	helicase
HHM65_RS02140	ENOG4108RWN	rrna methyltransferase
HHM65_RS02175	ENOG4108IJ7	Glycine betaine
HHM65_RS02195	ENOG4105FE9	pseudouridine synthase
HHM65_RS02210	ENOG4108SAX	Membrane
HHM65_RS02215	ENOG410841Q	phosphoesterase PA-phosphatase related protein
HHM65_RS02220	ENOG4105N5T	Radical SAM Protein
HHM65_RS02235	ENOG4105F1A	Pyruvate formate-lyase
HHM65_RS02250	ENOG4105EHG	Permease protein
HHM65_RS02255	ENOG4105DQ5	transport system permease protein
HHM65_RS02265	ENOG4105E0A	ABC, transporter
HHM65_RS02310	ENOG4105CP9	extracellular ligand-binding receptor
HHM65_RS02315	ENOG4105C32	Amino acid ABC transporter (Permease)
HHM65_RS02320	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HHM65_RS02325	ENOG4105C0Z	ABC transporter
HHM65_RS02330	ENOG4108IV0	ABC, transporter
HHM65_RS02335	ENOG41080XP	Cbs domain
HHM65_RS02345	ENOG4105FA2	dna polymerase iii
HHM65_RS02350	ENOG4105MA4	psp1 domain protein
HHM65_RS02360	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HHM65_RS02375	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HHM65_RS02385	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HHM65_RS02390	ENOG41080E8	Transcriptional regulator, Spx MgsR family
HHM65_RS02405	ENOG4105CGK	Exodeoxyribonuclease III
HHM65_RS02460	ENOG4105CWM	branched-chain amino acid transport system II carrier protein
HHM65_RS02475	ENOG4105CHR	reductase
HHM65_RS02495	ENOG4105CXY	transporter
HHM65_RS02515	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HHM65_RS02530	ENOG4105DIK	(ABC) transporter
HHM65_RS02535	ENOG4105CC5	ABC transporter
HHM65_RS02540	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HHM65_RS02545	ENOG4105CNU	cell division protein FtsK
HHM65_RS02610	ENOG4105C9A	Phoh family
HHM65_RS02615	ENOG4108RG0	uracil-dna glycosylase
HHM65_RS02625	ENOG4107YR5	Diacylglycerol kinase
HHM65_RS02635	ENOG4108JJA	ABC, transporter
HHM65_RS02670	ENOG41067QW	Transcriptional regulator
HHM65_RS02695	ENOG4105XB7	anti-repressor protein
HHM65_RS02995	ENOG4108WCX	response regulator
HHM65_RS03060	ENOG4105WT3	Transcriptional regulator
HHM65_RS03075	ENOG4105DA5	(ABC) transporter
HHM65_RS03085	ENOG4105D7A	ATP-binding protein
HHM65_RS03090	ENOG4105C6X	Major Facilitator
HHM65_RS03105	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HHM65_RS03110	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HHM65_RS03120	ENOG4105CKK	Glycosyl transferase, family 2
HHM65_RS03130	ENOG4108UYE	Lactoylglutathione lyase
HHM65_RS03135	ENOG4108RCM	Nitroreductase
HHM65_RS03140	ENOG4105DC7	peptidase M24
HHM65_RS03145	ENOG4105ETE	Transcriptional regulator (LacI family
HHM65_RS03155	ENOG4105W2C	Glycosyl transferase
HHM65_RS03160	ENOG4105BZF	Glycosyl transferase (Group 1
HHM65_RS03170	ENOG4108IUW	ABC transporter
HHM65_RS03185	ENOG4105CMT	Dihydroxyacetone kinase
HHM65_RS03195	ENOG4105CMT	Dihydroxyacetone kinase
HHM65_RS03200	ENOG4108UTZ	Dihydroxyacetone kinase
HHM65_RS03205	ENOG4105VDH	Dihydroxyacetone kinase
HHM65_RS03210	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HHM65_RS03235	ENOG4105DRP	amino acid AbC transporter
HHM65_RS03240	ENOG4105EAD	ABC transporter
HHM65_RS03245	ENOG4107RP9	extracellular solute-binding protein, family 3
HHM65_RS03255	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HHM65_RS03260	ENOG4105BZU	Histidine kinase
HHM65_RS03265	ENOG4105Q2H	domain protein
HHM65_RS03275	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HHM65_RS03295	ENOG4108HCJ	Hydrolase
HHM65_RS03300	ENOG410667J	hydrolase
HHM65_RS03305	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HHM65_RS03310	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HHM65_RS03315	ENOG4105CID	antiterminator
HHM65_RS03320	ENOG4105C5Y	PTS System
HHM65_RS03330	ENOG4108NNR	transporter substrate-binding protein
HHM65_RS03335	ENOG4108PJD	permease
HHM65_RS03345	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HHM65_RS03350	ENOG4105BZU	Histidine kinase
HHM65_RS03355	ENOG4107S17	Phosphate-binding protein
HHM65_RS03360	ENOG4105C8U	phosphate abc transporter
HHM65_RS03370	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HHM65_RS03375	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HHM65_RS03440	ENOG4105CFP	Peptidase U32
HHM65_RS03445	ENOG4105VEM	Conserved domain protein
HHM65_RS03455	ENOG4107T5J	pyridine nucleotide-disulfide oxidoreductase
HHM65_RS03485	ENOG4108Z66	YbaK ebsC protein
HHM65_RS03520	ENOG4108V06	Glutathione peroxidase
HHM65_RS03525	ENOG4105DPN	Oligoendopeptidase f
HHM65_RS03535	ENOG4105CNI	cell division protein FtsW
HHM65_RS03540	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HHM65_RS03615	ENOG4105DCI	Phosphohydrolase
HHM65_RS03635	ENOG4108M60	Transcriptional regulator
HHM65_RS03645	ENOG4105F3R	pts system mannose fructose sorbose family iid
HHM65_RS03650	ENOG4105ETZ	PTS System
HHM65_RS03655	ENOG4108RG5	PTS system N-acetylgalactosamine-specific transporter subunit IIB
HHM65_RS03660	ENOG4105EP8	Glycosyl Hydrolase Family 88
HHM65_RS03690	ENOG4106AM8	polysaccharide lyase family 8
HHM65_RS03710	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HHM65_RS03715	ENOG4105DMC	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3
HHM65_RS03720	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HHM65_RS03730	ENOG4105CAK	Cell division ATP-binding protein ftsE
HHM65_RS03735	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HHM65_RS03745	ENOG4105DVT	helicase
HHM65_RS03750	ENOG4105CHM	Aminotransferase
HHM65_RS03755	ENOG4105C5S	asparaginyl-tRNA synthetase
HHM65_RS03775	ENOG4105CIE	May be required for sporulation (By similarity)
HHM65_RS03790	ENOG4105FDP	GntR family transcriptional regulator
HHM65_RS03795	ENOG4105E70	isomerase
HHM65_RS03815	ENOG4105DAS	pts system
HHM65_RS03820	ENOG4105ETZ	PTS System
HHM65_RS03825	ENOG4105F3R	pts system mannose fructose sorbose family iid
HHM65_RS03845	ENOG4105SFS	phosphoesterase RecJ domain protein
HHM65_RS03850	ENOG4107YB6	acetyltransferase, (GNAT) family
HHM65_RS03875	ENOG4107R4J	Chloride channel
HHM65_RS03910	ENOG4105EAC	phosphoserine phosphatase
HHM65_RS03955	ENOG4105CJ1	ABC, transporter
HHM65_RS03975	ENOG410807C	QueT transporter
HHM65_RS03980	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HHM65_RS03985	ENOG4105CBD	Diacylglycerol kinase
HHM65_RS03990	ENOG4108IUM	Glycogen debranching enzyme
HHM65_RS03995	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HHM65_RS04015	ENOG4105ZA1	atp synthase
HHM65_RS04020	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
HHM65_RS04050	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HHM65_RS04070	ENOG4105ZT7	DNA-entry nuclease
HHM65_RS04075	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HHM65_RS04080	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HHM65_RS04095	ENOG4105I2S	Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity)
HHM65_RS04105	ENOG4105CGZ	zinc metallopeptidase
HHM65_RS04125	ENOG4106PMH	Extracellular solute-binding protein family 3
HHM65_RS04135	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HHM65_RS04140	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HHM65_RS04145	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HHM65_RS04150	ENOG4105VG1	fes assembly suf system protein
HHM65_RS04155	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HHM65_RS04175	ENOG4105EY8	ABC transporter
HHM65_RS04195	ENOG4106N3V	dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83)
HHM65_RS04260	ENOG4105DR4	Methyltransferase
HHM65_RS04270	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HHM65_RS04280	ENOG4105DC8	reductase
HHM65_RS04285	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HHM65_RS04295	ENOG4105C3J	Cysteine desulfurase
HHM65_RS04325	ENOG4105K46	50S ribosomal protein l27
HHM65_RS04330	ENOG4105CMU	LysR family (Transcriptional regulator
HHM65_RS04340	ENOG4105C34	Pseudouridine synthase
HHM65_RS04375	ENOG4107X8C	Efflux transporter RND family MFP subunit
HHM65_RS04380	ENOG4105C19	ABC transporter
HHM65_RS04385	ENOG4107RBB	ABC transporter, permease
HHM65_RS04395	ENOG4106MZZ	glycerophosphoryl diester phosphodiesterase
HHM65_RS04405	ENOG4105VB6	UPF0109 protein
HHM65_RS04455	ENOG4105E98	transcriptional regulator DeoR family
HHM65_RS04460	ENOG4105DE4	1-phosphofructokinase
HHM65_RS04465	ENOG4105DM4	PTS System
HHM65_RS04470	ENOG4107X35	defense response to bacterium
HHM65_RS04490	ENOG4105EPR	degv family
HHM65_RS04500	ENOG4105C5H	ABC transporter
HHM65_RS04510	ENOG4105BZ1	(ABC) transporter
HHM65_RS04515	ENOG4105D82	Glutamate dehydrogenase
HHM65_RS04520	ENOG4107YDN	peptide deformylase
HHM65_RS04525	ENOG4105CGH	5'-nucleotidase
HHM65_RS04535	ENOG4105BZ1	(ABC) transporter
HHM65_RS04540	ENOG4105BZ1	(ABC) transporter
HHM65_RS04590	ENOG4105F99	Hydroxymethylglutaryl-CoA synthase
HHM65_RS04600	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
HHM65_RS04615	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HHM65_RS04660	ENOG4107BJW	polysaccharide deacetylase
HHM65_RS04665	ENOG4105D6E	homoserine dehydrogenase
HHM65_RS04675	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HHM65_RS04710	ENOG4105F38	ABC transporter, permease
HHM65_RS04715	ENOG4105D38	putrescine abc transporter
HHM65_RS04720	ENOG4108HM4	ABC transporter
HHM65_RS04725	ENOG4108MRH	transcriptional regulatory protein
HHM65_RS04745	ENOG4105CMQ	Chloride channel
HHM65_RS04750	ENOG4105E7U	AraC family transcriptional regulator
HHM65_RS04790	ENOG4105C3J	Cysteine desulfurase
HHM65_RS04815	ENOG4105EMS	pseudouridine synthase
HHM65_RS04820	ENOG4108IJ2	phosphate acetyltransferase
HHM65_RS04825	ENOG4105EMU	Dehydrogenase
HHM65_RS04840	ENOG4105E90	ABC transporter
HHM65_RS04880	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HHM65_RS04885	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HHM65_RS04910	ENOG4105BZ1	(ABC) transporter
HHM65_RS04915	ENOG4105BZ1	(ABC) transporter
HHM65_RS04925	ENOG4105NAE	bifunctional deaminase-reductase domain protein
HHM65_RS04940	ENOG4108Z6X	(sortase) family
HHM65_RS04945	ENOG4108YZK	glyoxalase bleomycin resistance protein dioxygenase
HHM65_RS04980	ENOG4105C19	ABC transporter
HHM65_RS04985	ENOG4107RBB	ABC transporter, permease
HHM65_RS04990	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HHM65_RS05000	ENOG4108S4A	n-acetylmuramoyl-l-alanine amidase
HHM65_RS05025	ENOG4105DSE	periplasmic solute binding protein
HHM65_RS05045	ENOG4108JJB	ABC transporter
HHM65_RS05100	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHM65_RS05125	ENOG4105D9R	oxidoreductase
HHM65_RS05135	ENOG4108VK3	Cupin 2 Conserved Barrel Domain Protein
HHM65_RS05170	ENOG4105EWM	Histidine kinase
HHM65_RS05180	ENOG4108HVR	ABC transporter, permease
HHM65_RS05185	ENOG4105C19	ABC transporter
HHM65_RS05200	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
HHM65_RS05205	ENOG4107QSA	Oxaloacetate decarboxylase
HHM65_RS05235	ENOG4105D9Q	decarboxylase (Beta subunit)
HHM65_RS05240	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
HHM65_RS05250	ENOG4105D4T	Citrate transporter
HHM65_RS05270	ENOG4105D9Q	decarboxylase (Beta subunit)
HHM65_RS05275	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
HHM65_RS05285	ENOG4107QSA	Oxaloacetate decarboxylase
HHM65_RS05320	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HHM65_RS05325	ENOG4105C79	DNA protecting protein DprA
HHM65_RS05345	ENOG4105WT3	Transcriptional regulator
HHM65_RS05355	ENOG4108UT2	hemolysin iii
HHM65_RS05375	ENOG4105C5H	ABC transporter
HHM65_RS05400	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HHM65_RS05405	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HHM65_RS05410	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HHM65_RS05465	ENOG4105JGI	Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity)
HHM65_RS05475	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HHM65_RS05480	ENOG4105FH5	Membrane
HHM65_RS05495	ENOG4105UIB	(ABC) transporter
HHM65_RS05500	ENOG4108JQ9	ABC transporter
HHM65_RS05505	ENOG4105DIH	basic membrane
HHM65_RS05520	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HHM65_RS05525	ENOG4107Y49	methyltransferase
HHM65_RS05540	ENOG4105US7	Histidine kinase
HHM65_RS05545	ENOG4108STX	response regulator
HHM65_RS05555	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HHM65_RS05570	ENOG4105E2Z	phosphate ABC transporter (Permease
HHM65_RS05575	ENOG4105C8U	phosphate abc transporter
HHM65_RS05585	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HHM65_RS05590	ENOG4105ECY	inositol monophosphatase
HHM65_RS05600	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
HHM65_RS05605	ENOG4105DTN	riboflavin biosynthesis protein ribF
HHM65_RS05635	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HHM65_RS05675	ENOG4107BMA	Transglycosylase associated protein
HHM65_RS05685	ENOG4105C4R	Atp-dependent dna helicase
HHM65_RS05690	ENOG4105BZG	amino acid carrier protein
HHM65_RS05705	ENOG4106TNF	Periplasmic binding protein
HHM65_RS05710	ENOG4105CDA	abc transporter atp-binding protein
HHM65_RS05715	ENOG4105E5Q	amino acid AbC transporter
HHM65_RS05720	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HHM65_RS05735	ENOG4105CA9	Pyruvate kinase
HHM65_RS05750	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
HHM65_RS05755	ENOG4105CZV	ABC transporter
HHM65_RS05790	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HHM65_RS05810	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HHM65_RS05830	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HHM65_RS05850	ENOG4105E5Q	amino acid AbC transporter
HHM65_RS05855	ENOG4105E89	ABC transporter
HHM65_RS05865	ENOG4105DQ6	Transposase
HHM65_RS05875	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HHM65_RS05905	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
HHM65_RS05930	ENOG4107QSE	Dipeptidase
HHM65_RS05940	ENOG4105C7K	acetolactate synthase
HHM65_RS05945	ENOG4105C7K	acetolactate synthase
HHM65_RS05970	ENOG4105C26	Dehydrogenase
HHM65_RS05985	ENOG4107S21	permease
HHM65_RS06000	ENOG4107URF	beta-phospho-glucomutase
HHM65_RS06015	ENOG4107VQW	regulatoR
HHM65_RS06020	ENOG4105C2F	Histidine kinase
HHM65_RS06025	ENOG4105F3R	pts system mannose fructose sorbose family iid
HHM65_RS06030	ENOG4105ETZ	PTS System
HHM65_RS06115	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HHM65_RS06125	ENOG4105CSA	Coproporphyrinogen iii oxidase
HHM65_RS06145	ENOG4105C8B	TIGR00159 family
HHM65_RS06150	ENOG4105DMS	mur ligase
HHM65_RS06155	ENOG4105F1K	Glutamine amidotransferase
HHM65_RS06160	ENOG4105DF9	Lipoate-protein, ligase
HHM65_RS06170	ENOG4105U3E	Transcriptional regulator
HHM65_RS06175	ENOG4107QN2	dihydrolipoyl dehydrogenase
HHM65_RS06185	ENOG4105CPP	Dehydrogenase, E1 component
HHM65_RS06190	ENOG4107RUY	(E1 component), alpha subunit
HHM65_RS06195	ENOG4105C5H	ABC transporter
HHM65_RS06205	ENOG4107UWA	esterase
HHM65_RS06215	ENOG4108JJB	ABC transporter
HHM65_RS06245	ENOG4105F0S	class B acid phosphatase
HHM65_RS06270	ENOG41068YB	TPR repeat-containing protein
HHM65_RS06295	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HHM65_RS06305	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
HHM65_RS06310	ENOG4107VFR	oxidoreductase
HHM65_RS06330	ENOG4105CSM	endonuclease III
HHM65_RS06345	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HHM65_RS06350	ENOG4108IXY	short-chain dehydrogenase reductase
HHM65_RS06365	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HHM65_RS06385	ENOG4108RXX	maleylacetoacetate isomerase
HHM65_RS06400	ENOG4105C72	UPF0176 protein
HHM65_RS06410	ENOG4108YYH	Nadph-dependent fmn reductase
HHM65_RS06415	ENOG4108IUN	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
HHM65_RS06420	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
HHM65_RS06425	ENOG4105FKQ	transcriptional regulator
HHM65_RS06435	ENOG4107FKK	extracellular solute-binding protein family 1
HHM65_RS06445	ENOG4105EG2	ABC transporter, permease
HHM65_RS06450	ENOG4105ETE	Transcriptional regulator (LacI family
HHM65_RS06470	ENOG4108IUK	alpha amylase, catalytic
HHM65_RS06475	ENOG4107FKK	extracellular solute-binding protein family 1
HHM65_RS06480	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
HHM65_RS06490	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HHM65_RS06510	ENOG410600T	transposase
HHM65_RS06515	ENOG4105DRP	amino acid AbC transporter
HHM65_RS06520	ENOG4105CDA	abc transporter atp-binding protein
HHM65_RS06545	ENOG4105C88	aminopeptidase
HHM65_RS06570	ENOG4107RGD	Major Facilitator superfamily
HHM65_RS06580	ENOG4105C4B	ABC transporter, permease
HHM65_RS06585	ENOG41083J0	(ABC) transporter
HHM65_RS06660	ENOG4108JJB	ABC transporter
HHM65_RS06675	ENOG4105BZ1	(ABC) transporter
HHM65_RS06685	ENOG4105YA8	Transcriptional regulator
HHM65_RS06760	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HHM65_RS06860	ENOG4108JJB	ABC transporter
HHM65_RS06865	ENOG4105BZ1	(ABC) transporter
HHM65_RS06870	ENOG4105BZ1	(ABC) transporter
HHM65_RS06910	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HHM65_RS06915	ENOG4108RCF	TRANSCRIPTIONal
HHM65_RS06960	ENOG4105D17	glycoside hydrolase, family 3 domain protein
HHM65_RS06970	ENOG4105DMW	Dehydrogenase reductase
HHM65_RS06985	ENOG4108UHU	Aldolase
HHM65_RS06990	ENOG4107YCY	Transcriptional regulator
HHM65_RS06995	ENOG4105CNT	hydrolase family 2
HHM65_RS07005	ENOG4105CT4	transporter
HHM65_RS07025	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HHM65_RS07035	ENOG4105C6E	dna polymerase iii
HHM65_RS07040	ENOG4108ZGC	gaf domain protein
HHM65_RS07060	ENOG4105FDU	atp-dependent rna helicase
HHM65_RS07065	ENOG4108ZJ4	polysaccharide deacetylase
HHM65_RS07070	ENOG4105C26	Dehydrogenase
HHM65_RS07075	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HHM65_RS07080	ENOG4105KRI	phosphocarrier protein (HPr
HHM65_RS07085	ENOG4105WAZ	(Glutaredoxin-like protein) NrdH
HHM65_RS07090	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HHM65_RS07095	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HHM65_RS07115	ENOG4105VZ8	Transcriptional regulator
HHM65_RS07155	ENOG4108YYH	Nadph-dependent fmn reductase
HHM65_RS07210	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HHM65_RS07215	ENOG4105KQC	Competence protein
HHM65_RS07220	ENOG4105F6E	Acyl-transferase
HHM65_RS07225	ENOG41060K3	Methyltransferase
HHM65_RS07240	ENOG4105C1J	atp-dependent rna helicase
HHM65_RS07245	ENOG4105D01	(LipO)protein
HHM65_RS07250	ENOG4108UMI	ABC transporter, permease
HHM65_RS07255	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HHM65_RS07260	ENOG4105KWG	Pfam:DUF1696
HHM65_RS07275	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HHM65_RS07290	ENOG4107RF6	penicillin-binding protein
HHM65_RS07295	ENOG4105TMB	Formate nitrite transporter
HHM65_RS07300	ENOG4105RNB	
HHM65_RS07325	ENOG4105C59	p-type ATPase
HHM65_RS07350	ENOG41090WU	lipolytic protein G-D-S-L family
HHM65_RS07355	ENOG4108RCR	degv family
HHM65_RS07365	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HHM65_RS07370	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
HHM65_RS07375	ENOG4105DX0	Hemolysin A
HHM65_RS07410	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HHM65_RS07435	ENOG4105E5Q	amino acid AbC transporter
HHM65_RS07440	ENOG4107IN1	Protein of unknown function (DUF1797)
HHM65_RS07445	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HHM65_RS07450	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HHM65_RS07465	ENOG4105MMF	Cell division protein DIVIVA
HHM65_RS07485	ENOG4105DFA	alanine racemase domain protein
HHM65_RS07495	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HHM65_RS07525	ENOG4105CI3	gtp-binding protein typa
HHM65_RS07530	ENOG4107YZP	Rhodanese domain protein
HHM65_RS07535	ENOG4105DKQ	ROK family
HHM65_RS07545	ENOG4105HUF	DNA protection during starvation protein
HHM65_RS07555	ENOG4105BZ1	(ABC) transporter
HHM65_RS07560	ENOG4105BZ1	(ABC) transporter
HHM65_RS07570	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HHM65_RS07575	ENOG4105MMD	transcriptional regulator
HHM65_RS07590	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HHM65_RS07595	ENOG4105CNN	ABC, transporter
HHM65_RS07605	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
HHM65_RS07610	ENOG4108RVA	ribokinase
HHM65_RS07615	ENOG4105ETE	Transcriptional regulator (LacI family
HHM65_RS07620	ENOG41063PX	domain protein
HHM65_RS07630	ENOG4106H78	methyltransferase
HHM65_RS07640	ENOG4105C5B	carbamate kinase
HHM65_RS07650	ENOG4107QSE	Dipeptidase
HHM65_RS07655	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
HHM65_RS07670	ENOG4105CEU	Arginine dihydrolase
HHM65_RS07675	ENOG4105IJS	Transcriptional regulator
HHM65_RS07695	ENOG4105C2F	Histidine kinase
HHM65_RS07710	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHM65_RS07715	ENOG4107QIV	Cytochrome c biogenesis protein
HHM65_RS07730	ENOG4105KCF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
HHM65_RS07735	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HHM65_RS07765	ENOG410600T	transposase
HHM65_RS07785	ENOG4105HRU	Glyoxalase Bleomycin resistance protein (Dioxygenase
HHM65_RS07900	ENOG4108IMY	Transcriptional regulator
HHM65_RS07915	ENOG4106BHR	ftsk SpoIIIE family protein
HHM65_RS07955	ENOG4108IMY	Transcriptional regulator
HHM65_RS07990	ENOG4105ECQ	AraC Family Transcriptional Regulator
HHM65_RS07995	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HHM65_RS08030	ENOG4105CNT	hydrolase family 2
HHM65_RS08035	ENOG4105EQD	regulatoR
HHM65_RS08040	ENOG4105C2F	Histidine kinase
HHM65_RS08055	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HHM65_RS08080	ENOG4105CS2	ec 3.2.1.21
HHM65_RS08085	ENOG4105CPE	K01197 hyaluronoglucosaminidase EC 3.2.1.35
HHM65_RS08100	ENOG4105C8I	hydrolase, family 38
HHM65_RS08120	ENOG4105DEN	Luciferase family
HHM65_RS08140	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HHM65_RS08240	ENOG41081UC	Inherit from COG: Competence protein
HHM65_RS08250	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HHM65_RS08270	ENOG4105WH1	Two component transcriptional regulator luxr family
HHM65_RS08275	ENOG4105ENE	Histidine kinase
HHM65_RS08285	ENOG4105D9P	serine threonine protein kinase
HHM65_RS08295	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HHM65_RS08305	ENOG4105C25	Primosomal protein n'
HHM65_RS08325	ENOG4105CMU	LysR family (Transcriptional regulator
HHM65_RS08335	ENOG4107QP7	CoA-transferase subunit A
HHM65_RS08360	ENOG41070VT	
HHM65_RS08365	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HHM65_RS08385	ENOG410600T	transposase
HHM65_RS08395	ENOG4105BZ4	penicillin-binding protein
HHM65_RS08400	ENOG4105CTZ	aminopeptidase c
HHM65_RS08410	ENOG4105DAP	Nicotinate phosphoribosyltransferase
HHM65_RS08415	ENOG4105C85	amino acid
HHM65_RS08420	ENOG4105C3M	thioredoxin reductase
HHM65_RS08430	ENOG4105CDA	abc transporter atp-binding protein
HHM65_RS08435	ENOG4108HW4	amino acid AbC transporter
HHM65_RS08445	ENOG4105C1J	atp-dependent rna helicase
HHM65_RS08455	ENOG4105CJN	penicillin-binding protein
HHM65_RS08510	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HHM65_RS08515	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HHM65_RS08520	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HHM65_RS08550	ENOG4108WWS	isoprenylcysteine carboxyl methyltransferase
HHM65_RS08560	ENOG4105CE4	GlcNAc 6-P deacetylase
HHM65_RS08585	ENOG410667J	hydrolase
HHM65_RS08590	ENOG4105EN6	Membrane
HHM65_RS08600	ENOG4105DE4	1-phosphofructokinase
HHM65_RS08630	ENOG41082GB	PTS system galactitol-specific transporter subunit IIA
HHM65_RS08650	ENOG4105C59	p-type ATPase
HHM65_RS08655	ENOG4105NA0	Transcriptional regulator
HHM65_RS08680	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
HHM65_RS08685	ENOG4105CHV	Transcription elongation factor NusA
HHM65_RS08720	ENOG4105K59	histidine triad (HIT) protein
HHM65_RS08730	ENOG4108KGH	TRANSCRIPTIONal
HHM65_RS08735	ENOG4108MK9	spermidine N(1)-acetyltransferase
HHM65_RS08740	ENOG4105K8N	protein family UPF0079, ATPase
HHM65_RS08745	ENOG4105C7N	Xanthine uracil vitamin C permease
HHM65_RS08750	ENOG4108KP7	hydrolase
HHM65_RS08760	ENOG4105ETZ	PTS System
HHM65_RS08765	ENOG4105F3R	pts system mannose fructose sorbose family iid
HHM65_RS08780	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HHM65_RS08795	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HHM65_RS08810	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HHM65_RS08815	ENOG4105CHR	reductase
HHM65_RS08820	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HHM65_RS08825	ENOG4105EA8	2-Nitropropane dioxygenase
HHM65_RS08845	ENOG4105CGU	Enoyl-CoA hydratase
HHM65_RS08850	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HHM65_RS08890	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HHM65_RS08895	ENOG4107BMA	Transglycosylase associated protein
HHM65_RS08920	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HHM65_RS08925	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HHM65_RS08940	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HHM65_RS08950	ENOG4105VPX	protein, conserved in bacteria
HHM65_RS08965	ENOG4105CHM	Aminotransferase
HHM65_RS08980	ENOG4107RB3	L-asparaginase
HHM65_RS08985	ENOG4107RGM	aldo keto reductase
HHM65_RS08990	ENOG4105CB5	ATP-dependent DNA helicase recG
HHM65_RS08995	ENOG4108JJB	ABC transporter
HHM65_RS09010	ENOG4105BZ1	(ABC) transporter
HHM65_RS09015	ENOG4108JJ9	ABC, transporter
HHM65_RS09020	ENOG4105E0A	ABC, transporter
HHM65_RS09045	ENOG41068JE	domain protein
HHM65_RS09065	ENOG4105DG6	mannose-6-phosphate isomerase
HHM65_RS09070	ENOG4105EVU	fructokinase
HHM65_RS09075	ENOG4105C5Y	PTS System
HHM65_RS09085	ENOG4105ETE	Transcriptional regulator (LacI family
HHM65_RS09105	ENOG4108UK2	deaminase
HHM65_RS09110	ENOG4105DC7	peptidase M24
HHM65_RS09115	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HHM65_RS09150	ENOG4105CEN	a g-specific adenine glycosylase
HHM65_RS09160	ENOG4105K63	Thioredoxin
HHM65_RS09165	ENOG4107QN2	dihydrolipoyl dehydrogenase
HHM65_RS09190	ENOG4105C3F	Signal peptidase i
HHM65_RS09195	ENOG4105C7H	Helicase, RecD TraA family
HHM65_RS09210	ENOG4105C6N	Formate acetyltransferase
HHM65_RS09215	ENOG4107YB6	acetyltransferase, (GNAT) family
HHM65_RS09225	ENOG4105XN3	extracellular solute-binding protein family 1
HHM65_RS09235	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HHM65_RS09250	ENOG4107S1E	Beta-lactamase
HHM65_RS09265	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HHM65_RS09295	ENOG4107TXC	Transcriptional regulator
HHM65_RS09300	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HHM65_RS09310	ENOG4105CBX	hi0933 family
HHM65_RS09345	ENOG41072GX	Peptidase M22 Glycoprotease
HHM65_RS09360	ENOG4108JQ7	(ABC) transporter
HHM65_RS09370	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HHM65_RS09375	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HHM65_RS09380	ENOG4108J59	Extracellular solute-binding protein, family 5
HHM65_RS09385	ENOG4105C5F	glutamine synthetase
HHM65_RS09390	ENOG4105KV4	Transcriptional regulator
HHM65_RS09405	ENOG4105CUR	5'-nucleotidase, lipoprotein e(p4) family
HHM65_RS09410	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HHM65_RS09420	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HHM65_RS09435	ENOG4105DFT	pur operon repressor
HHM65_RS09440	ENOG4105EQI	Metal Dependent Phosphohydrolase
HHM65_RS09450	ENOG4105FJ0	thiamine
HHM65_RS09455	ENOG4105DJV	ribulose-phosphate 3-epimerase
HHM65_RS09475	ENOG4105F8V	Hydrolase, tatD family
HHM65_RS09485	ENOG4105D3W	isochorismatase
HHM65_RS09515	ENOG4105DRS	transport system, permease
HHM65_RS09520	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HHM65_RS09610	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HHM65_RS09615	ENOG4105WPN	DNA integration recombination invertion protein
HHM65_RS09620	ENOG4105BZ1	(ABC) transporter
HHM65_RS09625	ENOG4105BZ1	(ABC) transporter
HHM65_RS09640	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HHM65_RS09650	ENOG4107ZXI	Rhomboid family
HHM65_RS09655	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HHM65_RS09695	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHM65_RS09725	ENOG4108RQ5	Beta-lactamase domain-containing protein
HHM65_RS09730	ENOG41080Y5	BioY family
HHM65_RS09755	ENOG4105K4P	CoA-binding domain protein
HHM65_RS09760	ENOG4105C2M	dna polymerase I
HHM65_RS09770	ENOG4108IJ7	Glycine betaine
HHM65_RS09775	ENOG4105CBD	Diacylglycerol kinase
HHM65_RS09795	ENOG41064BZ	L-xylulose 5-phosphate 3-epimerase
HHM65_RS09845	ENOG4105BZ1	(ABC) transporter
HHM65_RS09850	ENOG4105CUZ	uba thif-type nad fad binding protein
HHM65_RS09900	ENOG4105BZ4	penicillin-binding protein
HHM65_RS09915	ENOG4108YBP	pseudouridine synthase
HHM65_RS09945	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HHM65_RS09980	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HHM65_RS10000	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HHM65_RS10055	ENOG4105CDU	Replicative dna helicase
HHM65_RS10245	ENOG4105D3R	alkyl hydroperoxide reductase
HHM65_RS10260	ENOG4105CGP	Urocanate hydratase
HHM65_RS10265	ENOG4105CCS	Glutamate formiminotransferase
HHM65_RS10270	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
HHM65_RS10285	ENOG4107R7I	amino acid
HHM65_RS10305	ENOG4105CE9	30S ribosomal protein S2
HHM65_RS10315	ENOG4105C9K	Endothelin-converting enzyme 1
HHM65_RS10320	ENOG4105CG3	alpha amylase, catalytic region
HHM65_RS10325	ENOG4105C5Y	PTS System
HHM65_RS10330	ENOG4107414	GntR family transcriptional regulator
HHM65_RS10350	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HHM65_RS10360	ENOG4105EP9	oxidoreductase
HHM65_RS10370	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HHM65_RS10390	ENOG4105VBH	UPF0297 protein
HHM65_RS10395	ENOG410888K	transcriptional regulator, Spx
HHM65_RS10420	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HHM65_RS10430	ENOG4105D94	Major Facilitator Superfamily
HHM65_RS10450	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
HHM65_RS10465	ENOG4108JYZ	YitT family
HHM65_RS10475	ENOG4107AYK	membrAne
HHM65_RS10560	ENOG4105ECB	domain protein
HHM65_RS10700	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
HHM65_RS10705	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HHM65_RS10710	ENOG410600T	transposase
HHM65_RS10725	ENOG4105CDU	Replicative dna helicase
HHM65_RS10750	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HHM65_RS10765	ENOG4105EJQ	L-serine dehydratase
HHM65_RS10775	ENOG4106770	Is able to cleave peptidoglycan (By similarity)
HHM65_RS10795	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HHM65_RS10830	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HHM65_RS10845	ENOG4105C5H	ABC transporter
HHM65_RS10880	ENOG4105C0H	protease