locus-tag	class	description
HHM65_RS00010	COG0592	DNA-directed DNA polymerase activity
HHM65_RS00025	COG0012	GTP binding
HHM65_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHM65_RS00040	COG2244	polysaccharide biosynthetic process
HHM65_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HHM65_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHM65_RS00075	COG0531	amino acid
HHM65_RS00260	COG3942	CHAP domain
HHM65_RS00280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HHM65_RS00285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HHM65_RS00290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HHM65_RS00300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HHM65_RS00305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHM65_RS00325	COG0151	Belongs to the GarS family
HHM65_RS00330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HHM65_RS00350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HHM65_RS00365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHM65_RS00380	COG1012	belongs to the aldehyde dehydrogenase family
HHM65_RS00380	COG1454	alcohol dehydrogenase
HHM65_RS00385	COG1064	alcohol dehydrogenase
HHM65_RS00390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HHM65_RS00405	COG0051	transcription antitermination factor activity, RNA binding
HHM65_RS00505	COG0200	Binds to the 23S rRNA
HHM65_RS00510	COG0201	protein transport
HHM65_RS00530	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHM65_RS00645	COG0582	viral genome integration into host DNA
HHM65_RS00670	COG1395	domain, Protein
HHM65_RS00695	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HHM65_RS00705	COG1252	NADH dehydrogenase
HHM65_RS00710	COG1271	oxidase subunit
HHM65_RS00715	COG1294	oxidase, subunit
HHM65_RS00720	COG4988	ABC transporter
HHM65_RS00725	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HHM65_RS00730	COG0142	geranyltranstransferase activity
HHM65_RS00745	COG1121	(ABC) transporter
HHM65_RS00750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHM65_RS00760	COG4499	WXG100 protein secretion system (Wss), protein YukC
HHM65_RS00760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHM65_RS00780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHM65_RS00785	COG1459	type II secretion system
HHM65_RS00790	COG4537	Required for transformation and DNA binding
HHM65_RS00830	COG1266	CAAX protease self-immunity
HHM65_RS00840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHM65_RS00845	COG1363	Peptidase, m42
HHM65_RS00855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHM65_RS00860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHM65_RS00870	COG1428	Deoxynucleoside kinase
HHM65_RS00875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HHM65_RS00930	COG0251	oxidation-reduction process
HHM65_RS00955	COG1744	ABC transporter substrate-binding protein PnrA-like
HHM65_RS00960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHM65_RS00965	COG1349	DNA-binding transcription factor activity
HHM65_RS00970	COG2390	Transcriptional regulator
HHM65_RS00975	COG1447	Phosphotransferase system cellobiose-specific component IIA
HHM65_RS00980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHM65_RS00985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHM65_RS00990	COG1882	Formate acetyltransferase
HHM65_RS01010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HHM65_RS01035	COG3655	Transcriptional regulator
HHM65_RS01100	COG1132	(ABC) transporter
HHM65_RS01170	COG1122	ATPase activity
HHM65_RS01195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HHM65_RS01200	COG0512	Glutamine amidotransferase of anthranilate synthase
HHM65_RS01205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHM65_RS01240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HHM65_RS01245	COG1609	Transcriptional regulator
HHM65_RS01250	COG1263	PTS System
HHM65_RS01250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM65_RS01250	COG2190	(PTS) system
HHM65_RS01265	COG1363	Peptidase, m42
HHM65_RS01315	COG3842	ATPase activity
HHM65_RS01325	COG1523	belongs to the glycosyl hydrolase 13 family
HHM65_RS01340	COG1862	Preprotein translocase
HHM65_RS01350	COG4589	Belongs to the CDS family
HHM65_RS01375	COG1846	Transcriptional regulator
HHM65_RS01405	COG3711	transcriptional antiterminator
HHM65_RS01415	COG3037	sugar-specific permease SgaT UlaA
HHM65_RS01420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHM65_RS01435	COG1045	serine acetyltransferase
HHM65_RS01450	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HHM65_RS01470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHM65_RS01490	COG1476	TRANSCRIPTIONal
HHM65_RS01505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HHM65_RS01555	COG2274	protein secretion by the type I secretion system
HHM65_RS01560	COG1136	(ABC) transporter
HHM65_RS01565	COG0577	efflux transmembrane transporter activity
HHM65_RS01610	COG3775	system Galactitol-specific IIC component
HHM65_RS01615	COG3414	Phosphotransferase system galactitol-specific IIB component
HHM65_RS01635	COG0561	phosphatase activity
HHM65_RS01680	COG0527	aspartate kinase activity
HHM65_RS01690	COG0351	phosphomethylpyrimidine kinase
HHM65_RS01695	COG4720	Psort location CytoplasmicMembrane, score
HHM65_RS01705	COG0668	transmembrane transport
HHM65_RS01715	COG0366	Alpha amylase catalytic
HHM65_RS01725	COG3343	RNA polymerase activity
HHM65_RS01740	COG3279	Response regulator of the LytR AlgR family
HHM65_RS01750	COG1346	cytolysis
HHM65_RS01800	COG0765	amino acid transport
HHM65_RS01820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHM65_RS01830	COG0719	Fe-S assembly protein
HHM65_RS01835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HHM65_RS01850	COG1686	Belongs to the peptidase S11 family
HHM65_RS01855	COG1686	Belongs to the peptidase S11 family
HHM65_RS01860	COG4166	transmembrane transport
HHM65_RS01865	COG0601	transmembrane transport
HHM65_RS01870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHM65_RS01875	COG0444	Belongs to the ABC transporter superfamily
HHM65_RS01930	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HHM65_RS01935	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HHM65_RS01940	COG1534	Rna-binding protein
HHM65_RS01950	COG1713	HD superfamily hydrolase involved in NAD metabolism
HHM65_RS01960	COG0799	negative regulation of ribosome biogenesis
HHM65_RS01965	COG2226	methyltransferase
HHM65_RS01975	COG0789	Transcriptional regulator
HHM65_RS01990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HHM65_RS02000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHM65_RS02010	COG1464	Belongs to the NlpA lipoprotein family
HHM65_RS02015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHM65_RS02030	COG1114	Component of the transport system for branched-chain amino acids
HHM65_RS02040	COG0569	domain protein
HHM65_RS02045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHM65_RS02055	COG1704	LemA family
HHM65_RS02070	COG0745	RESPONSE REGULATOR receiver
HHM65_RS02075	COG5002	protein histidine kinase activity
HHM65_RS02080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHM65_RS02090	COG1484	DNA-dependent DNA replication
HHM65_RS02100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHM65_RS02120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HHM65_RS02135	COG1254	Belongs to the acylphosphatase family
HHM65_RS02140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHM65_RS02175	COG4175	Glycine betaine
HHM65_RS02195	COG1187	pseudouridine synthase activity
HHM65_RS02210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HHM65_RS02215	COG0671	phosphoesterase, PA-phosphatase related
HHM65_RS02220	COG1242	4 iron, 4 sulfur cluster binding
HHM65_RS02225	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HHM65_RS02230	COG1253	flavin adenine dinucleotide binding
HHM65_RS02235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHM65_RS02250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHM65_RS02255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHM65_RS02260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HHM65_RS02265	COG1120	ATPase activity
HHM65_RS02275	COG2244	polysaccharide biosynthetic process
HHM65_RS02315	COG0559	Belongs to the binding-protein-dependent transport system permease family
HHM65_RS02325	COG0411	ABC transporter
HHM65_RS02335	COG0517	IMP dehydrogenase activity
HHM65_RS02345	COG0470	DNA polymerase III
HHM65_RS02350	COG1774	PSP1 C-terminal conserved region
HHM65_RS02375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HHM65_RS02390	COG1393	Belongs to the ArsC family
HHM65_RS02405	COG0708	Exodeoxyribonuclease III
HHM65_RS02415	COG1620	l-lactate permease
HHM65_RS02420	COG1304	FMN binding
HHM65_RS02460	COG1114	Component of the transport system for branched-chain amino acids
HHM65_RS02475	COG1028	Short-chain dehydrogenase reductase Sdr
HHM65_RS02490	COG0673	inositol 2-dehydrogenase activity
HHM65_RS02515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HHM65_RS02540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHM65_RS02610	COG1702	phosphate starvation-inducible protein PhoH
HHM65_RS02615	COG1573	uracil-dna glycosylase
HHM65_RS02625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HHM65_RS02635	COG2274	protein secretion by the type I secretion system
HHM65_RS02670	COG3620	sequence-specific DNA binding
HHM65_RS02695	COG3561	AntA/AntB antirepressor
HHM65_RS02840	COG5484	DNA packaging
HHM65_RS02995	COG3279	Response regulator of the LytR AlgR family
HHM65_RS03060	COG1396	sequence-specific DNA binding
HHM65_RS03075	COG1131	(ABC) transporter
HHM65_RS03085	COG0433	COG0433 Predicted ATPase
HHM65_RS03090	COG2814	Major facilitator Superfamily
HHM65_RS03105	COG0557	exoribonuclease II activity
HHM65_RS03110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HHM65_RS03120	COG0463	Glycosyl transferase, family 2
HHM65_RS03130	COG0346	lactoylglutathione lyase activity
HHM65_RS03135	COG0778	Nitroreductase
HHM65_RS03140	COG0006	proline dipeptidase activity
HHM65_RS03145	COG1609	Transcriptional regulator
HHM65_RS03160	COG0438	transferase activity, transferring glycosyl groups
HHM65_RS03170	COG4555	ABC transporter
HHM65_RS03185	COG2376	Dihydroxyacetone kinase
HHM65_RS03195	COG2376	Dihydroxyacetone kinase
HHM65_RS03200	COG1461	Dihydroxyacetone kinase
HHM65_RS03205	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HHM65_RS03210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHM65_RS03220	COG0183	Belongs to the thiolase family
HHM65_RS03235	COG0765	amino acid transport
HHM65_RS03240	COG0765	amino acid transport
HHM65_RS03245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHM65_RS03255	COG0745	RESPONSE REGULATOR receiver
HHM65_RS03260	COG5002	protein histidine kinase activity
HHM65_RS03265	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HHM65_RS03275	COG1196	nuclear chromosome segregation
HHM65_RS03295	COG0561	phosphatase activity
HHM65_RS03300	COG0561	phosphatase activity
HHM65_RS03305	COG0552	protein localization to endoplasmic reticulum
HHM65_RS03310	COG0477	Major facilitator Superfamily
HHM65_RS03315	COG3711	transcriptional antiterminator
HHM65_RS03320	COG2190	(PTS) system
HHM65_RS03320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM65_RS03320	COG1263	PTS System
HHM65_RS03330	COG3689	TIGRFAM TIGR03943 family protein
HHM65_RS03335	COG0701	Predicted permease
HHM65_RS03345	COG0745	RESPONSE REGULATOR receiver
HHM65_RS03350	COG5002	protein histidine kinase activity
HHM65_RS03355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HHM65_RS03360	COG0573	inorganic phosphate transmembrane transporter activity
HHM65_RS03370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHM65_RS03375	COG0704	Plays a role in the regulation of phosphate uptake
HHM65_RS03390	COG2183	response to ionizing radiation
HHM65_RS03445	COG4443	Transcriptional Coactivator p15 (PC4)
HHM65_RS03485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HHM65_RS03520	COG0386	Belongs to the glutathione peroxidase family
HHM65_RS03525	COG1164	Oligoendopeptidase f
HHM65_RS03535	COG0772	Belongs to the SEDS family
HHM65_RS03540	COG1191	sigma factor activity
HHM65_RS03615	COG1078	dGTPase activity
HHM65_RS03635	COG1609	Transcriptional regulator
HHM65_RS03645	COG3716	PTS system mannose fructose sorbose family IID component
HHM65_RS03650	COG3715	PTS system
HHM65_RS03655	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM65_RS03670	COG1028	Short-chain dehydrogenase reductase Sdr
HHM65_RS03690	COG5492	domain, Protein
HHM65_RS03710	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHM65_RS03715	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HHM65_RS03720	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHM65_RS03730	COG2884	Cell division ATP-binding protein ftsE
HHM65_RS03735	COG2177	Part of the ABC transporter FtsEX involved in
HHM65_RS03745	COG1199	ATP-dependent helicase activity
HHM65_RS03745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HHM65_RS03750	COG0436	Aminotransferase
HHM65_RS03755	COG0017	Asparaginyl-tRNA synthetase
HHM65_RS03790	COG2188	Transcriptional regulator
HHM65_RS03795	COG2222	sugar isomerase
HHM65_RS03815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHM65_RS03815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM65_RS03820	COG3715	PTS system
HHM65_RS03825	COG3716	PTS system mannose fructose sorbose family IID component
HHM65_RS03845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HHM65_RS03850	COG2153	protein acetylation
HHM65_RS03855	COG0625	glutathione transferase activity
HHM65_RS03865	COG0716	FMN binding
HHM65_RS03875	COG0038	chloride channel
HHM65_RS03890	COG0772	Belongs to the SEDS family
HHM65_RS03910	COG0560	Phosphoserine phosphatase
HHM65_RS03955	COG1131	(ABC) transporter
HHM65_RS03975	COG4708	membrane
HHM65_RS03985	COG1597	lipid kinase activity
HHM65_RS03990	COG1523	belongs to the glycosyl hydrolase 13 family
HHM65_RS03995	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HHM65_RS04000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HHM65_RS04005	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HHM65_RS04095	COG0577	efflux transmembrane transporter activity
HHM65_RS04105	COG2321	neutral zinc metallopeptidase
HHM65_RS04120	COG0436	Aminotransferase
HHM65_RS04135	COG1970	mechanosensitive ion channel activity
HHM65_RS04140	COG0358	DNA primase activity
HHM65_RS04145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHM65_RS04150	COG2151	metal-sulfur cluster biosynthetic enzyme
HHM65_RS04165	COG1442	glycosyl transferase family 8
HHM65_RS04165	COG1216	Glycosyl transferase, family 2
HHM65_RS04195	COG1216	Glycosyl transferase, family 2
HHM65_RS04255	COG1368	sulfuric ester hydrolase activity
HHM65_RS04260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HHM65_RS04280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHM65_RS04285	COG0285	dihydrofolate synthase activity
HHM65_RS04295	COG1104	cysteine desulfurase activity
HHM65_RS04325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HHM65_RS04330	COG0583	DNA-binding transcription factor activity
HHM65_RS04340	COG0564	pseudouridine synthase activity
HHM65_RS04375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHM65_RS04380	COG1136	(ABC) transporter
HHM65_RS04385	COG0577	efflux transmembrane transporter activity
HHM65_RS04395	COG0584	glycerophosphoryl diester phosphodiesterase
HHM65_RS04405	COG1837	Belongs to the UPF0109 family
HHM65_RS04455	COG1349	DNA-binding transcription factor activity
HHM65_RS04460	COG1105	Belongs to the carbohydrate kinase PfkB family
HHM65_RS04465	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHM65_RS04465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHM65_RS04465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHM65_RS04470	COG1388	LysM domain
HHM65_RS04470	COG1705	Flagellar rod assembly protein muramidase FlgJ
HHM65_RS04475	COG1705	Flagellar rod assembly protein muramidase FlgJ
HHM65_RS04475	COG1388	LysM domain
HHM65_RS04500	COG0488	(ABC) transporter
HHM65_RS04510	COG1132	(ABC) transporter
HHM65_RS04515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HHM65_RS04520	COG0242	peptide deformylase activity
HHM65_RS04525	COG0737	Belongs to the 5'-nucleotidase family
HHM65_RS04535	COG1132	(ABC) transporter
HHM65_RS04540	COG1132	(ABC) transporter
HHM65_RS04590	COG3425	synthase
HHM65_RS04600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHM65_RS04655	COG1686	Belongs to the peptidase S11 family
HHM65_RS04660	COG0726	polysaccharide deacetylase
HHM65_RS04675	COG0285	dihydrofolate synthase activity
HHM65_RS04680	COG0302	gtp cyclohydrolase
HHM65_RS04710	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHM65_RS04715	COG1177	transmembrane transport
HHM65_RS04725	COG4565	transcriptional regulatory protein
HHM65_RS04730	COG3290	protein histidine kinase activity
HHM65_RS04735	COG3493	citrate carrier protein
HHM65_RS04745	COG0038	chloride channel
HHM65_RS04750	COG4977	sequence-specific DNA binding
HHM65_RS04750	COG1917	Cupin 2, conserved barrel domain protein
HHM65_RS04760	COG0628	permease
HHM65_RS04770	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HHM65_RS04790	COG1104	cysteine desulfurase activity
HHM65_RS04805	COG2357	RelA SpoT domain protein
HHM65_RS04815	COG0564	pseudouridine synthase activity
HHM65_RS04820	COG0280	phosphate acetyltransferase
HHM65_RS04825	COG4221	oxidoreductase activity
HHM65_RS04840	COG1174	glycine betaine transport
HHM65_RS04855	COG2233	PERMEase
HHM65_RS04880	COG2890	protein-(glutamine-N5) methyltransferase activity
HHM65_RS04885	COG0009	L-threonylcarbamoyladenylate synthase
HHM65_RS04910	COG1132	(ABC) transporter
HHM65_RS04915	COG1132	(ABC) transporter
HHM65_RS04925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHM65_RS04940	COG3764	Sortase (surface protein transpeptidase)
HHM65_RS04945	COG0346	lactoylglutathione lyase activity
HHM65_RS04980	COG1136	(ABC) transporter
HHM65_RS04985	COG0577	efflux transmembrane transporter activity
HHM65_RS04990	COG0745	RESPONSE REGULATOR receiver
HHM65_RS04995	COG2205	protein histidine kinase activity
HHM65_RS05000	COG1705	Flagellar rod assembly protein muramidase FlgJ
HHM65_RS05000	COG3942	CHAP domain
HHM65_RS05025	COG0803	Belongs to the bacterial solute-binding protein 9 family
HHM65_RS05045	COG1122	ATPase activity
HHM65_RS05055	COG0601	transmembrane transport
HHM65_RS05090	COG2188	Transcriptional regulator
HHM65_RS05100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHM65_RS05125	COG0673	inositol 2-dehydrogenase activity
HHM65_RS05130	COG5002	protein histidine kinase activity
HHM65_RS05135	COG0662	Cupin 2, conserved barrel domain protein
HHM65_RS05170	COG5002	protein histidine kinase activity
HHM65_RS05175	COG0745	RESPONSE REGULATOR receiver
HHM65_RS05180	COG0577	efflux transmembrane transporter activity
HHM65_RS05185	COG1136	(ABC) transporter
HHM65_RS05200	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HHM65_RS05235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HHM65_RS05240	COG0511	ligase activity, forming carbon-carbon bonds
HHM65_RS05250	COG2851	Citrate transporter
HHM65_RS05270	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HHM65_RS05275	COG0511	ligase activity, forming carbon-carbon bonds
HHM65_RS05320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHM65_RS05325	COG0758	DNA mediated transformation
HHM65_RS05345	COG1396	sequence-specific DNA binding
HHM65_RS05355	COG1272	protein, Hemolysin III
HHM65_RS05375	COG0488	(ABC) transporter
HHM65_RS05395	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHM65_RS05400	COG1328	CTP reductase activity
HHM65_RS05400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHM65_RS05405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHM65_RS05410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHM65_RS05465	COG0095	Lipoate-protein ligase
HHM65_RS05475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHM65_RS05480	COG4684	Psort location CytoplasmicMembrane, score
HHM65_RS05485	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHM65_RS05505	COG1744	ABC transporter substrate-binding protein PnrA-like
HHM65_RS05520	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HHM65_RS05525	COG2813	Specifically methylates the guanine in position
HHM65_RS05540	COG5002	protein histidine kinase activity
HHM65_RS05545	COG0745	RESPONSE REGULATOR receiver
HHM65_RS05555	COG0704	Plays a role in the regulation of phosphate uptake
HHM65_RS05570	COG0581	inorganic phosphate transmembrane transporter activity
HHM65_RS05575	COG0573	inorganic phosphate transmembrane transporter activity
HHM65_RS05585	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHM65_RS05585	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HHM65_RS05590	COG0483	inositol monophosphate 1-phosphatase activity
HHM65_RS05605	COG0196	riboflavin kinase activity
HHM65_RS05635	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHM65_RS05635	COG1136	(ABC) transporter
HHM65_RS05675	COG2261	transglycosylase associated protein
HHM65_RS05690	COG1115	amino acid carrier protein
HHM65_RS05695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HHM65_RS05705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHM65_RS05710	COG1126	abc transporter atp-binding protein
HHM65_RS05715	COG0765	amino acid transport
HHM65_RS05720	COG2824	Alkylphosphonate utilization operon protein PhnA
HHM65_RS05735	COG0469	pyruvate kinase activity
HHM65_RS05750	COG1725	Transcriptional regulator
HHM65_RS05755	COG1131	(ABC) transporter
HHM65_RS05765	COG0398	Pfam SNARE associated Golgi protein
HHM65_RS05790	COG0539	negative regulation of cytoplasmic translation
HHM65_RS05810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHM65_RS05830	COG0187	DNA topoisomerase II activity
HHM65_RS05850	COG0765	amino acid transport
HHM65_RS05865	COG2801	Transposase and inactivated derivatives
HHM65_RS05905	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HHM65_RS05930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHM65_RS05940	COG0028	Belongs to the TPP enzyme family
HHM65_RS05945	COG0028	Belongs to the TPP enzyme family
HHM65_RS05955	COG0028	Belongs to the TPP enzyme family
HHM65_RS05970	COG1012	belongs to the aldehyde dehydrogenase family
HHM65_RS05975	COG1011	Hydrolase
HHM65_RS05985	COG0701	Predicted permease
HHM65_RS06000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHM65_RS06015	COG2207	Transcriptional regulator
HHM65_RS06015	COG4753	response regulator
HHM65_RS06020	COG2972	Histidine kinase
HHM65_RS06025	COG3716	PTS system mannose fructose sorbose family IID component
HHM65_RS06030	COG3715	PTS system
HHM65_RS06095	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HHM65_RS06100	COG1518	maintenance of DNA repeat elements
HHM65_RS06115	COG0647	UMP catabolic process
HHM65_RS06125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHM65_RS06145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HHM65_RS06150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHM65_RS06155	COG3442	glutamine amidotransferase
HHM65_RS06160	COG0095	Lipoate-protein ligase
HHM65_RS06170	COG1695	Transcriptional regulator
HHM65_RS06180	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHM65_RS06185	COG0022	dehydrogenase e1 component
HHM65_RS06185	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHM65_RS06190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHM65_RS06195	COG0488	(ABC) transporter
HHM65_RS06215	COG1122	ATPase activity
HHM65_RS06245	COG3700	Belongs to the class B bacterial acid phosphatase family
HHM65_RS06265	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HHM65_RS06270	COG0457	Tetratricopeptide repeat
HHM65_RS06275	COG0628	permease
HHM65_RS06280	COG1051	belongs to the nudix hydrolase family
HHM65_RS06295	COG1088	dTDP-glucose 4,6-dehydratase activity
HHM65_RS06305	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HHM65_RS06310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHM65_RS06325	COG2384	SAM-dependent methyltransferase
HHM65_RS06330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHM65_RS06345	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHM65_RS06345	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HHM65_RS06350	COG0300	oxidoreductase activity
HHM65_RS06365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHM65_RS06410	COG0431	NADPH-dependent FMN reductase
HHM65_RS06415	COG0058	SHG alpha-glucan phosphorylase activity
HHM65_RS06420	COG1640	4-alpha-glucanotransferase
HHM65_RS06425	COG1609	Transcriptional regulator
HHM65_RS06435	COG2182	Extracellular solute-binding protein
HHM65_RS06445	COG3833	ABC-type maltose transport systems, permease component
HHM65_RS06470	COG0366	Alpha amylase catalytic
HHM65_RS06475	COG2182	Extracellular solute-binding protein
HHM65_RS06480	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HHM65_RS06490	COG1696	Membrane protein involved in D-alanine export
HHM65_RS06510	COG5433	transposase activity
HHM65_RS06515	COG0765	amino acid transport
HHM65_RS06520	COG1126	abc transporter atp-binding protein
HHM65_RS06545	COG2309	aminopeptidase activity
HHM65_RS06560	COG1187	pseudouridine synthase activity
HHM65_RS06570	COG2814	Major facilitator Superfamily
HHM65_RS06580	COG0390	transport system, permease component
HHM65_RS06585	COG4619	ABC transporter
HHM65_RS06655	COG0534	Mate efflux family protein
HHM65_RS06660	COG1129	ABC transporter
HHM65_RS06675	COG1132	(ABC) transporter
HHM65_RS06685	COG1309	transcriptional regulator
HHM65_RS06760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHM65_RS06760	COG0551	DNA topoisomerase type I activity
HHM65_RS06860	COG1129	ABC transporter
HHM65_RS06865	COG1132	(ABC) transporter
HHM65_RS06870	COG1132	(ABC) transporter
HHM65_RS06910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHM65_RS06940	COG4109	DRTGG domain
HHM65_RS06970	COG1028	Short-chain dehydrogenase reductase Sdr
HHM65_RS06985	COG0800	Aldolase
HHM65_RS06990	COG2186	Transcriptional regulator
HHM65_RS06995	COG3250	beta-galactosidase activity
HHM65_RS07005	COG2211	Major facilitator Superfamily
HHM65_RS07025	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HHM65_RS07025	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HHM65_RS07035	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHM65_RS07040	COG1956	GAF domain-containing protein
HHM65_RS07060	COG0513	Belongs to the DEAD box helicase family
HHM65_RS07065	COG0726	polysaccharide deacetylase
HHM65_RS07085	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHM65_RS07090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHM65_RS07095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHM65_RS07115	COG1476	TRANSCRIPTIONal
HHM65_RS07135	COG4122	O-methyltransferase activity
HHM65_RS07140	COG2223	nitrite transmembrane transporter activity
HHM65_RS07155	COG0431	NADPH-dependent FMN reductase
HHM65_RS07175	COG1187	pseudouridine synthase activity
HHM65_RS07210	COG0658	competence protein
HHM65_RS07210	COG2333	competence protein COMEC
HHM65_RS07215	COG1555	photosystem II stabilization
HHM65_RS07215	COG1596	polysaccharide export
HHM65_RS07220	COG0204	Acyl-transferase
HHM65_RS07225	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HHM65_RS07240	COG0513	Belongs to the DEAD box helicase family
HHM65_RS07245	COG1464	Belongs to the NlpA lipoprotein family
HHM65_RS07255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHM65_RS07275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHM65_RS07290	COG0768	penicillin binding
HHM65_RS07295	COG2116	formate transmembrane transporter activity
HHM65_RS07305	COG1827	regulation of RNA biosynthetic process
HHM65_RS07325	COG2217	Heavy metal translocating P-type atpase
HHM65_RS07350	COG2755	lipolytic protein G-D-S-L family
HHM65_RS07365	COG0497	DNA recombination
HHM65_RS07370	COG1438	arginine binding
HHM65_RS07375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HHM65_RS07405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHM65_RS07435	COG0765	amino acid transport
HHM65_RS07440	COG4703	Protein of unknown function (DUF1797)
HHM65_RS07445	COG0542	response to heat
HHM65_RS07450	COG1051	belongs to the nudix hydrolase family
HHM65_RS07465	COG3599	regulation of cell shape
HHM65_RS07485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HHM65_RS07495	COG0849	cell division
HHM65_RS07530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHM65_RS07535	COG1940	carbohydrate kinase activity
HHM65_RS07545	COG0783	Belongs to the Dps family
HHM65_RS07555	COG1132	(ABC) transporter
HHM65_RS07560	COG1132	(ABC) transporter
HHM65_RS07570	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HHM65_RS07575	COG4470	Protein conserved in bacteria
HHM65_RS07590	COG1879	ABC-type sugar transport system periplasmic component
HHM65_RS07595	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHM65_RS07605	COG1869	D-ribose catabolic process
HHM65_RS07610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHM65_RS07615	COG1609	Transcriptional regulator
HHM65_RS07620	COG3480	Lon protease (S16) C-terminal proteolytic domain
HHM65_RS07630	COG0742	ribosomal rna small subunit methyltransferase
HHM65_RS07640	COG0549	Belongs to the carbamate kinase family
HHM65_RS07650	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHM65_RS07655	COG1288	antiporter activity
HHM65_RS07665	COG0454	-acetyltransferase
HHM65_RS07670	COG2235	arginine
HHM65_RS07675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHM65_RS07695	COG2972	Histidine kinase
HHM65_RS07710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHM65_RS07715	COG0785	Cytochrome C biogenesis protein
HHM65_RS07725	COG0673	inositol 2-dehydrogenase activity
HHM65_RS07730	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HHM65_RS07735	COG1518	maintenance of DNA repeat elements
HHM65_RS07765	COG5433	transposase activity
HHM65_RS07785	COG0346	lactoylglutathione lyase activity
HHM65_RS07855	COG0433	COG0433 Predicted ATPase
HHM65_RS07900	COG1396	sequence-specific DNA binding
HHM65_RS07915	COG1674	ftsk spoiiie
HHM65_RS07955	COG1396	sequence-specific DNA binding
HHM65_RS07995	COG1605	Chorismate mutase
HHM65_RS07995	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HHM65_RS08030	COG3250	beta-galactosidase activity
HHM65_RS08035	COG2207	Transcriptional regulator
HHM65_RS08035	COG4753	response regulator
HHM65_RS08040	COG2972	Histidine kinase
HHM65_RS08055	COG0395	ABC-type sugar transport system, permease component
HHM65_RS08060	COG1175	transmembrane transport
HHM65_RS08080	COG2723	6-phospho-beta-galactosidase activity
HHM65_RS08085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HHM65_RS08100	COG0383	alpha-mannosidase activity
HHM65_RS08120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHM65_RS08130	COG2070	2-Nitropropane dioxygenase
HHM65_RS08140	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHM65_RS08140	COG1024	Enoyl-CoA hydratase
HHM65_RS08240	COG1040	competence protein
HHM65_RS08245	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HHM65_RS08250	COG1739	Uncharacterized protein family UPF0029
HHM65_RS08260	COG1098	S1 RNA binding domain
HHM65_RS08270	COG2197	response regulator
HHM65_RS08275	COG4585	Histidine kinase
HHM65_RS08285	COG2815	serine threonine protein kinase
HHM65_RS08285	COG0515	serine threonine protein kinase
HHM65_RS08295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHM65_RS08295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHM65_RS08305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHM65_RS08325	COG0583	DNA-binding transcription factor activity
HHM65_RS08330	COG0183	Belongs to the thiolase family
HHM65_RS08335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HHM65_RS08365	COG0116	Belongs to the methyltransferase superfamily
HHM65_RS08385	COG5433	transposase activity
HHM65_RS08395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHM65_RS08400	COG3579	cysteine-type endopeptidase activity
HHM65_RS08410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HHM65_RS08415	COG1113	amino acid transport
HHM65_RS08420	COG0492	ferredoxin-NADP+ reductase activity
HHM65_RS08430	COG1126	abc transporter atp-binding protein
HHM65_RS08435	COG0765	amino acid transport
HHM65_RS08445	COG0513	Belongs to the DEAD box helicase family
HHM65_RS08455	COG0768	penicillin binding
HHM65_RS08485	COG1131	(ABC) transporter
HHM65_RS08510	COG0446	pyridine nucleotide-disulphide oxidoreductase
HHM65_RS08515	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHM65_RS08550	COG1755	Isoprenylcysteine carboxyl methyltransferase
HHM65_RS08555	COG0656	L-ascorbic acid biosynthetic process
HHM65_RS08565	COG1283	sodium-dependent phosphate transmembrane transporter activity
HHM65_RS08585	COG0561	phosphatase activity
HHM65_RS08590	COG2860	membrane
HHM65_RS08600	COG1105	Belongs to the carbohydrate kinase PfkB family
HHM65_RS08630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHM65_RS08650	COG2217	Heavy metal translocating P-type atpase
HHM65_RS08680	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HHM65_RS08685	COG0195	Participates in both transcription termination and antitermination
HHM65_RS08710	COG4473	ABC transporter
HHM65_RS08715	COG1131	(ABC) transporter
HHM65_RS08720	COG0537	adenosine 5'-monophosphoramidase activity
HHM65_RS08730	COG1316	TRANSCRIPTIONal
HHM65_RS08735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHM65_RS08740	COG0802	atpase or kinase
HHM65_RS08745	COG2252	PERMEase
HHM65_RS08750	COG0561	phosphatase activity
HHM65_RS08760	COG3715	PTS system
HHM65_RS08765	COG3716	PTS system mannose fructose sorbose family IID component
HHM65_RS08795	COG0439	Biotin carboxylase
HHM65_RS08810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HHM65_RS08815	COG1028	Short-chain dehydrogenase reductase Sdr
HHM65_RS08820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HHM65_RS08825	COG2070	2-Nitropropane dioxygenase
HHM65_RS08845	COG1024	Enoyl-CoA hydratase
HHM65_RS08850	COG0484	heat shock protein binding
HHM65_RS08870	COG1420	regulation of RNA biosynthetic process
HHM65_RS08890	COG0588	phosphoglycerate mutase activity
HHM65_RS08895	COG2261	transglycosylase associated protein
HHM65_RS08920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHM65_RS08920	COG0574	Belongs to the PEP-utilizing enzyme family
HHM65_RS08925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HHM65_RS08930	COG0517	IMP dehydrogenase activity
HHM65_RS08940	COG0446	pyridine nucleotide-disulphide oxidoreductase
HHM65_RS08950	COG1937	Protein conserved in bacteria
HHM65_RS08955	COG1335	isochorismatase
HHM65_RS08965	COG0436	Aminotransferase
HHM65_RS08975	COG0561	phosphatase activity
HHM65_RS08980	COG0252	asparaginase activity
HHM65_RS08985	COG4989	oxidoreductase activity
HHM65_RS08990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HHM65_RS08995	COG1129	ABC transporter
HHM65_RS09010	COG1132	(ABC) transporter
HHM65_RS09015	COG4988	ABC transporter
HHM65_RS09020	COG1120	ATPase activity
HHM65_RS09045	COG3942	CHAP domain
HHM65_RS09045	COG1388	LysM domain
HHM65_RS09065	COG1482	cell wall glycoprotein biosynthetic process
HHM65_RS09070	COG1940	carbohydrate kinase activity
HHM65_RS09075	COG2190	(PTS) system
HHM65_RS09075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM65_RS09075	COG1263	PTS System
HHM65_RS09080	COG1621	beta-fructofuranosidase activity
HHM65_RS09085	COG1609	Transcriptional regulator
HHM65_RS09105	COG2131	deaminase
HHM65_RS09110	COG0006	proline dipeptidase activity
HHM65_RS09150	COG1194	a g-specific adenine glycosylase
HHM65_RS09160	COG3118	belongs to the thioredoxin family
HHM65_RS09165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHM65_RS09190	COG0681	Belongs to the peptidase S26 family
HHM65_RS09195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHM65_RS09210	COG1882	Formate acetyltransferase
HHM65_RS09215	COG2153	protein acetylation
HHM65_RS09225	COG1653	transport
HHM65_RS09235	COG0395	ABC-type sugar transport system, permease component
HHM65_RS09240	COG4209	transmembrane transport
HHM65_RS09250	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HHM65_RS09265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHM65_RS09295	COG0789	Transcriptional regulator
HHM65_RS09310	COG2081	HI0933 family
HHM65_RS09345	COG1214	PFAM Peptidase M22, glycoprotease
HHM65_RS09360	COG4608	Belongs to the ABC transporter superfamily
HHM65_RS09365	COG0444	Belongs to the ABC transporter superfamily
HHM65_RS09370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHM65_RS09375	COG0601	transmembrane transport
HHM65_RS09380	COG4166	transmembrane transport
HHM65_RS09385	COG0174	glutamine synthetase
HHM65_RS09390	COG0789	Transcriptional regulator
HHM65_RS09405	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HHM65_RS09435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHM65_RS09450	COG1564	THIamine pyrophosphokinase
HHM65_RS09475	COG0084	hydrolase, TatD family'
HHM65_RS09485	COG1335	isochorismatase
HHM65_RS09500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHM65_RS09515	COG0395	ABC-type sugar transport system, permease component
HHM65_RS09520	COG1175	transmembrane transport
HHM65_RS09545	COG1847	R3H domain protein
HHM65_RS09610	COG0756	dUTP diphosphatase activity
HHM65_RS09620	COG1132	(ABC) transporter
HHM65_RS09625	COG1132	(ABC) transporter
HHM65_RS09640	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HHM65_RS09650	COG0705	Rhomboid family
HHM65_RS09650	COG0457	Tetratricopeptide repeat
HHM65_RS09655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HHM65_RS09695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHM65_RS09725	COG1234	tRNA 3'-trailer cleavage
HHM65_RS09730	COG1268	BioY protein
HHM65_RS09755	COG1832	CoA-binding protein
HHM65_RS09760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHM65_RS09760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHM65_RS09770	COG3448	diguanylate cyclase activity
HHM65_RS09770	COG4175	Glycine betaine
HHM65_RS09775	COG1597	lipid kinase activity
HHM65_RS09795	COG3623	hexulose-6-phosphate isomerase
HHM65_RS09845	COG1132	(ABC) transporter
HHM65_RS09850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HHM65_RS09900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHM65_RS09915	COG0564	pseudouridine synthase activity
HHM65_RS09945	COG0542	response to heat
HHM65_RS09950	COG4463	regulation of RNA biosynthetic process
HHM65_RS09980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHM65_RS10000	COG4974	Belongs to the 'phage' integrase family
HHM65_RS10055	COG0305	Participates in initiation and elongation during chromosome replication
HHM65_RS10120	COG0582	viral genome integration into host DNA
HHM65_RS10245	COG0450	alkyl hydroperoxide reductase
HHM65_RS10260	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HHM65_RS10270	COG3404	Formiminotransferase-cyclodeaminase
HHM65_RS10285	COG0531	amino acid
HHM65_RS10315	COG3590	peptidase
HHM65_RS10320	COG0366	Alpha amylase catalytic
HHM65_RS10325	COG1263	PTS System
HHM65_RS10325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM65_RS10330	COG2188	Transcriptional regulator
HHM65_RS10350	COG0602	queuosine metabolic process
HHM65_RS10390	COG4472	Bacterial protein of unknown function (DUF965)
HHM65_RS10395	COG1393	Belongs to the ArsC family
HHM65_RS10420	COG0519	Catalyzes the synthesis of GMP from XMP
HHM65_RS10430	COG2814	Major facilitator Superfamily
HHM65_RS10465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHM65_RS10470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHM65_RS10475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHM65_RS10560	COG1511	domain protein
HHM65_RS10700	COG0582	viral genome integration into host DNA
HHM65_RS10705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHM65_RS10710	COG5433	transposase activity
HHM65_RS10725	COG0305	Participates in initiation and elongation during chromosome replication
HHM65_RS10750	COG2095	MarC family integral membrane protein
HHM65_RS10760	COG1760	l-serine dehydratase
HHM65_RS10765	COG1760	l-serine dehydratase
HHM65_RS10775	COG0741	lytic transglycosylase activity
HHM65_RS10795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHM65_RS10805	COG0612	Peptidase, M16
HHM65_RS10830	COG0517	IMP dehydrogenase activity
HHM65_RS10830	COG0516	GMP reductase activity
HHM65_RS10840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHM65_RS10845	COG0488	(ABC) transporter
HHM65_RS10880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain