locus-tag	class	description
HHM66_RS00010	COG0592	DNA-directed DNA polymerase activity
HHM66_RS00025	COG0012	GTP binding
HHM66_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHM66_RS00040	COG2244	polysaccharide biosynthetic process
HHM66_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HHM66_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHM66_RS00075	COG0531	amino acid
HHM66_RS00265	COG3942	CHAP domain
HHM66_RS00285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HHM66_RS00290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HHM66_RS00295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HHM66_RS00305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HHM66_RS00310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHM66_RS00330	COG0151	Belongs to the GarS family
HHM66_RS00335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HHM66_RS00355	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HHM66_RS00370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHM66_RS00385	COG1454	alcohol dehydrogenase
HHM66_RS00385	COG1012	belongs to the aldehyde dehydrogenase family
HHM66_RS00390	COG1064	alcohol dehydrogenase
HHM66_RS00395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HHM66_RS00410	COG0051	transcription antitermination factor activity, RNA binding
HHM66_RS00510	COG0200	Binds to the 23S rRNA
HHM66_RS00515	COG0201	protein transport
HHM66_RS00535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHM66_RS00650	COG0582	viral genome integration into host DNA
HHM66_RS00675	COG1395	domain, Protein
HHM66_RS00700	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HHM66_RS00710	COG1252	NADH dehydrogenase
HHM66_RS00715	COG1271	oxidase subunit
HHM66_RS00720	COG1294	oxidase, subunit
HHM66_RS00725	COG4988	ABC transporter
HHM66_RS00730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HHM66_RS00735	COG0142	geranyltranstransferase activity
HHM66_RS00750	COG1121	(ABC) transporter
HHM66_RS00755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHM66_RS00765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHM66_RS00765	COG4499	WXG100 protein secretion system (Wss), protein YukC
HHM66_RS00785	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HHM66_RS00790	COG1459	type II secretion system
HHM66_RS00795	COG4537	Required for transformation and DNA binding
HHM66_RS00835	COG1266	CAAX protease self-immunity
HHM66_RS00845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HHM66_RS00850	COG1363	Peptidase, m42
HHM66_RS00860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHM66_RS00865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHM66_RS00875	COG1428	Deoxynucleoside kinase
HHM66_RS00880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HHM66_RS00935	COG0251	oxidation-reduction process
HHM66_RS00960	COG1744	ABC transporter substrate-binding protein PnrA-like
HHM66_RS00965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHM66_RS00970	COG1349	DNA-binding transcription factor activity
HHM66_RS00975	COG2390	Transcriptional regulator
HHM66_RS00980	COG1447	Phosphotransferase system cellobiose-specific component IIA
HHM66_RS00985	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHM66_RS00990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HHM66_RS00995	COG1882	Formate acetyltransferase
HHM66_RS01010	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HHM66_RS01035	COG3655	Transcriptional regulator
HHM66_RS01100	COG1132	(ABC) transporter
HHM66_RS01195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HHM66_RS01200	COG0512	Glutamine amidotransferase of anthranilate synthase
HHM66_RS01205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HHM66_RS01240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HHM66_RS01245	COG1609	Transcriptional regulator
HHM66_RS01250	COG1263	PTS System
HHM66_RS01250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM66_RS01250	COG2190	(PTS) system
HHM66_RS01265	COG1363	Peptidase, m42
HHM66_RS01315	COG3842	ATPase activity
HHM66_RS01325	COG1523	belongs to the glycosyl hydrolase 13 family
HHM66_RS01340	COG1862	Preprotein translocase
HHM66_RS01350	COG4589	Belongs to the CDS family
HHM66_RS01375	COG1846	Transcriptional regulator
HHM66_RS01405	COG3711	transcriptional antiterminator
HHM66_RS01415	COG3037	sugar-specific permease SgaT UlaA
HHM66_RS01420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHM66_RS01435	COG1045	serine acetyltransferase
HHM66_RS01450	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HHM66_RS01470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHM66_RS01490	COG1476	TRANSCRIPTIONal
HHM66_RS01505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HHM66_RS01555	COG2274	protein secretion by the type I secretion system
HHM66_RS01560	COG1136	(ABC) transporter
HHM66_RS01565	COG0577	efflux transmembrane transporter activity
HHM66_RS01610	COG3775	system Galactitol-specific IIC component
HHM66_RS01615	COG3414	Phosphotransferase system galactitol-specific IIB component
HHM66_RS01635	COG0561	phosphatase activity
HHM66_RS01680	COG0527	aspartate kinase activity
HHM66_RS01690	COG0351	phosphomethylpyrimidine kinase
HHM66_RS01695	COG4720	Psort location CytoplasmicMembrane, score
HHM66_RS01705	COG0668	transmembrane transport
HHM66_RS01715	COG0366	Alpha amylase catalytic
HHM66_RS01725	COG3343	RNA polymerase activity
HHM66_RS01740	COG3279	Response regulator of the LytR AlgR family
HHM66_RS01750	COG1346	cytolysis
HHM66_RS01800	COG0765	amino acid transport
HHM66_RS01820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHM66_RS01830	COG0719	Fe-S assembly protein
HHM66_RS01835	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HHM66_RS01850	COG1686	Belongs to the peptidase S11 family
HHM66_RS01855	COG1686	Belongs to the peptidase S11 family
HHM66_RS01860	COG4166	transmembrane transport
HHM66_RS01865	COG0601	transmembrane transport
HHM66_RS01870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHM66_RS01875	COG0444	Belongs to the ABC transporter superfamily
HHM66_RS01930	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HHM66_RS01935	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HHM66_RS01940	COG1534	Rna-binding protein
HHM66_RS01950	COG1713	HD superfamily hydrolase involved in NAD metabolism
HHM66_RS01960	COG0799	negative regulation of ribosome biogenesis
HHM66_RS01965	COG2226	methyltransferase
HHM66_RS01975	COG0789	Transcriptional regulator
HHM66_RS01990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HHM66_RS02000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHM66_RS02010	COG1464	Belongs to the NlpA lipoprotein family
HHM66_RS02015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHM66_RS02030	COG1114	Component of the transport system for branched-chain amino acids
HHM66_RS02040	COG0569	domain protein
HHM66_RS02045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHM66_RS02055	COG1704	LemA family
HHM66_RS02070	COG0745	RESPONSE REGULATOR receiver
HHM66_RS02075	COG5002	protein histidine kinase activity
HHM66_RS02080	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHM66_RS02090	COG1484	DNA-dependent DNA replication
HHM66_RS02100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HHM66_RS02120	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HHM66_RS02135	COG1254	Belongs to the acylphosphatase family
HHM66_RS02140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHM66_RS02175	COG4175	Glycine betaine
HHM66_RS02195	COG1187	pseudouridine synthase activity
HHM66_RS02210	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HHM66_RS02215	COG0671	phosphoesterase, PA-phosphatase related
HHM66_RS02220	COG1242	4 iron, 4 sulfur cluster binding
HHM66_RS02225	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HHM66_RS02230	COG1253	flavin adenine dinucleotide binding
HHM66_RS02235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HHM66_RS02250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHM66_RS02255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHM66_RS02260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HHM66_RS02265	COG1120	ATPase activity
HHM66_RS02275	COG2244	polysaccharide biosynthetic process
HHM66_RS02315	COG0559	Belongs to the binding-protein-dependent transport system permease family
HHM66_RS02325	COG0411	ABC transporter
HHM66_RS02335	COG0517	IMP dehydrogenase activity
HHM66_RS02345	COG0470	DNA polymerase III
HHM66_RS02350	COG1774	PSP1 C-terminal conserved region
HHM66_RS02375	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HHM66_RS02390	COG1393	Belongs to the ArsC family
HHM66_RS02405	COG0708	Exodeoxyribonuclease III
HHM66_RS02415	COG1620	l-lactate permease
HHM66_RS02420	COG1304	FMN binding
HHM66_RS02460	COG1114	Component of the transport system for branched-chain amino acids
HHM66_RS02475	COG1028	Short-chain dehydrogenase reductase Sdr
HHM66_RS02490	COG0673	inositol 2-dehydrogenase activity
HHM66_RS02515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HHM66_RS02540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHM66_RS02610	COG1702	phosphate starvation-inducible protein PhoH
HHM66_RS02615	COG1573	uracil-dna glycosylase
HHM66_RS02625	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HHM66_RS02635	COG2274	protein secretion by the type I secretion system
HHM66_RS02665	COG3279	Response regulator of the LytR AlgR family
HHM66_RS02730	COG1396	sequence-specific DNA binding
HHM66_RS02745	COG1131	(ABC) transporter
HHM66_RS02755	COG0433	COG0433 Predicted ATPase
HHM66_RS02760	COG2814	Major facilitator Superfamily
HHM66_RS02775	COG0557	exoribonuclease II activity
HHM66_RS02780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HHM66_RS02790	COG0463	Glycosyl transferase, family 2
HHM66_RS02800	COG0346	lactoylglutathione lyase activity
HHM66_RS02805	COG0778	Nitroreductase
HHM66_RS02810	COG0006	proline dipeptidase activity
HHM66_RS02815	COG1609	Transcriptional regulator
HHM66_RS02830	COG0438	transferase activity, transferring glycosyl groups
HHM66_RS02840	COG4555	ABC transporter
HHM66_RS02855	COG2376	Dihydroxyacetone kinase
HHM66_RS02865	COG2376	Dihydroxyacetone kinase
HHM66_RS02870	COG1461	Dihydroxyacetone kinase
HHM66_RS02875	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HHM66_RS02880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHM66_RS02890	COG0183	Belongs to the thiolase family
HHM66_RS02905	COG0765	amino acid transport
HHM66_RS02910	COG0765	amino acid transport
HHM66_RS02915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHM66_RS02925	COG0745	RESPONSE REGULATOR receiver
HHM66_RS02930	COG5002	protein histidine kinase activity
HHM66_RS02935	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HHM66_RS02945	COG1196	nuclear chromosome segregation
HHM66_RS02965	COG0561	phosphatase activity
HHM66_RS02970	COG0561	phosphatase activity
HHM66_RS02975	COG0552	protein localization to endoplasmic reticulum
HHM66_RS02980	COG0477	Major facilitator Superfamily
HHM66_RS02985	COG3711	transcriptional antiterminator
HHM66_RS02990	COG1263	PTS System
HHM66_RS02990	COG2190	(PTS) system
HHM66_RS02990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM66_RS03000	COG3689	TIGRFAM TIGR03943 family protein
HHM66_RS03005	COG0701	Predicted permease
HHM66_RS03015	COG0745	RESPONSE REGULATOR receiver
HHM66_RS03020	COG5002	protein histidine kinase activity
HHM66_RS03025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HHM66_RS03030	COG0573	inorganic phosphate transmembrane transporter activity
HHM66_RS03040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHM66_RS03045	COG0704	Plays a role in the regulation of phosphate uptake
HHM66_RS03060	COG2183	response to ionizing radiation
HHM66_RS03110	COG4443	Transcriptional Coactivator p15 (PC4)
HHM66_RS03150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HHM66_RS03185	COG0386	Belongs to the glutathione peroxidase family
HHM66_RS03190	COG1164	Oligoendopeptidase f
HHM66_RS03200	COG0772	Belongs to the SEDS family
HHM66_RS03205	COG1191	sigma factor activity
HHM66_RS03280	COG1078	dGTPase activity
HHM66_RS03300	COG1609	Transcriptional regulator
HHM66_RS03310	COG3716	PTS system mannose fructose sorbose family IID component
HHM66_RS03315	COG3715	PTS system
HHM66_RS03320	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM66_RS03335	COG1028	Short-chain dehydrogenase reductase Sdr
HHM66_RS03355	COG5492	domain, Protein
HHM66_RS03375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHM66_RS03380	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HHM66_RS03385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHM66_RS03395	COG2884	Cell division ATP-binding protein ftsE
HHM66_RS03400	COG2177	Part of the ABC transporter FtsEX involved in
HHM66_RS03410	COG1199	ATP-dependent helicase activity
HHM66_RS03410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HHM66_RS03415	COG0436	Aminotransferase
HHM66_RS03420	COG0017	Asparaginyl-tRNA synthetase
HHM66_RS03455	COG2188	Transcriptional regulator
HHM66_RS03460	COG2222	sugar isomerase
HHM66_RS03480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHM66_RS03480	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM66_RS03485	COG3715	PTS system
HHM66_RS03490	COG3716	PTS system mannose fructose sorbose family IID component
HHM66_RS03510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HHM66_RS03515	COG2153	protein acetylation
HHM66_RS03520	COG0625	glutathione transferase activity
HHM66_RS03530	COG0716	FMN binding
HHM66_RS03540	COG0038	chloride channel
HHM66_RS03555	COG0772	Belongs to the SEDS family
HHM66_RS03575	COG0560	Phosphoserine phosphatase
HHM66_RS03620	COG1131	(ABC) transporter
HHM66_RS03640	COG4708	membrane
HHM66_RS03650	COG1597	lipid kinase activity
HHM66_RS03655	COG1523	belongs to the glycosyl hydrolase 13 family
HHM66_RS03660	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HHM66_RS03665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HHM66_RS03670	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HHM66_RS03760	COG0577	efflux transmembrane transporter activity
HHM66_RS03770	COG2321	neutral zinc metallopeptidase
HHM66_RS03785	COG0436	Aminotransferase
HHM66_RS03800	COG1970	mechanosensitive ion channel activity
HHM66_RS03805	COG0358	DNA primase activity
HHM66_RS03810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHM66_RS03815	COG2151	metal-sulfur cluster biosynthetic enzyme
HHM66_RS03830	COG1216	Glycosyl transferase, family 2
HHM66_RS03830	COG1442	glycosyl transferase family 8
HHM66_RS03860	COG1216	Glycosyl transferase, family 2
HHM66_RS03920	COG1368	sulfuric ester hydrolase activity
HHM66_RS03925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HHM66_RS03945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHM66_RS03950	COG0285	dihydrofolate synthase activity
HHM66_RS03960	COG1104	cysteine desulfurase activity
HHM66_RS03990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HHM66_RS03995	COG0583	DNA-binding transcription factor activity
HHM66_RS04005	COG0564	pseudouridine synthase activity
HHM66_RS04040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHM66_RS04045	COG1136	(ABC) transporter
HHM66_RS04050	COG0577	efflux transmembrane transporter activity
HHM66_RS04060	COG0584	glycerophosphoryl diester phosphodiesterase
HHM66_RS04070	COG1837	Belongs to the UPF0109 family
HHM66_RS04120	COG1349	DNA-binding transcription factor activity
HHM66_RS04125	COG1105	Belongs to the carbohydrate kinase PfkB family
HHM66_RS04130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHM66_RS04130	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHM66_RS04130	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HHM66_RS04135	COG1388	LysM domain
HHM66_RS04135	COG1705	Flagellar rod assembly protein muramidase FlgJ
HHM66_RS04140	COG1388	LysM domain
HHM66_RS04140	COG1705	Flagellar rod assembly protein muramidase FlgJ
HHM66_RS04165	COG0488	(ABC) transporter
HHM66_RS04175	COG1132	(ABC) transporter
HHM66_RS04180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HHM66_RS04185	COG0242	peptide deformylase activity
HHM66_RS04190	COG0737	Belongs to the 5'-nucleotidase family
HHM66_RS04200	COG1132	(ABC) transporter
HHM66_RS04205	COG1132	(ABC) transporter
HHM66_RS04255	COG3425	synthase
HHM66_RS04265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHM66_RS04320	COG1686	Belongs to the peptidase S11 family
HHM66_RS04325	COG0726	polysaccharide deacetylase
HHM66_RS04340	COG0285	dihydrofolate synthase activity
HHM66_RS04345	COG0302	gtp cyclohydrolase
HHM66_RS04375	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHM66_RS04380	COG1177	transmembrane transport
HHM66_RS04390	COG4565	transcriptional regulatory protein
HHM66_RS04395	COG3290	protein histidine kinase activity
HHM66_RS04400	COG3493	citrate carrier protein
HHM66_RS04410	COG0038	chloride channel
HHM66_RS04415	COG1917	Cupin 2, conserved barrel domain protein
HHM66_RS04415	COG4977	sequence-specific DNA binding
HHM66_RS04425	COG0628	permease
HHM66_RS04435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HHM66_RS04455	COG1104	cysteine desulfurase activity
HHM66_RS04470	COG2357	RelA SpoT domain protein
HHM66_RS04480	COG0564	pseudouridine synthase activity
HHM66_RS04485	COG0280	phosphate acetyltransferase
HHM66_RS04490	COG4221	oxidoreductase activity
HHM66_RS04505	COG1174	glycine betaine transport
HHM66_RS04520	COG2233	PERMEase
HHM66_RS04545	COG2890	protein-(glutamine-N5) methyltransferase activity
HHM66_RS04550	COG0009	L-threonylcarbamoyladenylate synthase
HHM66_RS04575	COG1132	(ABC) transporter
HHM66_RS04580	COG1132	(ABC) transporter
HHM66_RS04590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HHM66_RS04605	COG3764	Sortase (surface protein transpeptidase)
HHM66_RS04610	COG0346	lactoylglutathione lyase activity
HHM66_RS04645	COG1136	(ABC) transporter
HHM66_RS04650	COG0577	efflux transmembrane transporter activity
HHM66_RS04655	COG0745	RESPONSE REGULATOR receiver
HHM66_RS04660	COG2205	protein histidine kinase activity
HHM66_RS04665	COG3942	CHAP domain
HHM66_RS04665	COG1705	Flagellar rod assembly protein muramidase FlgJ
HHM66_RS04690	COG0803	Belongs to the bacterial solute-binding protein 9 family
HHM66_RS04710	COG1122	ATPase activity
HHM66_RS04720	COG0601	transmembrane transport
HHM66_RS04755	COG2188	Transcriptional regulator
HHM66_RS04765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHM66_RS04790	COG0673	inositol 2-dehydrogenase activity
HHM66_RS04795	COG5002	protein histidine kinase activity
HHM66_RS04800	COG0662	Cupin 2, conserved barrel domain protein
HHM66_RS04835	COG5002	protein histidine kinase activity
HHM66_RS04840	COG0745	RESPONSE REGULATOR receiver
HHM66_RS04845	COG0577	efflux transmembrane transporter activity
HHM66_RS04850	COG1136	(ABC) transporter
HHM66_RS04865	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HHM66_RS04900	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HHM66_RS04905	COG0511	ligase activity, forming carbon-carbon bonds
HHM66_RS04915	COG2851	Citrate transporter
HHM66_RS04935	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HHM66_RS04940	COG0511	ligase activity, forming carbon-carbon bonds
HHM66_RS04985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHM66_RS04990	COG0758	DNA mediated transformation
HHM66_RS05010	COG1396	sequence-specific DNA binding
HHM66_RS05020	COG1272	protein, Hemolysin III
HHM66_RS05040	COG0488	(ABC) transporter
HHM66_RS05060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHM66_RS05065	COG1328	CTP reductase activity
HHM66_RS05065	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHM66_RS05070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHM66_RS05075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHM66_RS05130	COG0095	Lipoate-protein ligase
HHM66_RS05140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHM66_RS05145	COG4684	Psort location CytoplasmicMembrane, score
HHM66_RS05150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHM66_RS05170	COG1744	ABC transporter substrate-binding protein PnrA-like
HHM66_RS05185	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HHM66_RS05190	COG2813	Specifically methylates the guanine in position
HHM66_RS05205	COG5002	protein histidine kinase activity
HHM66_RS05210	COG0745	RESPONSE REGULATOR receiver
HHM66_RS05220	COG0704	Plays a role in the regulation of phosphate uptake
HHM66_RS05235	COG0581	inorganic phosphate transmembrane transporter activity
HHM66_RS05240	COG0573	inorganic phosphate transmembrane transporter activity
HHM66_RS05250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHM66_RS05250	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HHM66_RS05255	COG0483	inositol monophosphate 1-phosphatase activity
HHM66_RS05270	COG0196	riboflavin kinase activity
HHM66_RS05300	COG1136	(ABC) transporter
HHM66_RS05300	COG4591	ABC-type transport system involved in lipoprotein release permease component
HHM66_RS05340	COG2261	transglycosylase associated protein
HHM66_RS05355	COG1115	amino acid carrier protein
HHM66_RS05360	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HHM66_RS05370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHM66_RS05375	COG1126	abc transporter atp-binding protein
HHM66_RS05380	COG0765	amino acid transport
HHM66_RS05385	COG2824	Alkylphosphonate utilization operon protein PhnA
HHM66_RS05400	COG0469	pyruvate kinase activity
HHM66_RS05415	COG1725	Transcriptional regulator
HHM66_RS05420	COG1131	(ABC) transporter
HHM66_RS05430	COG0398	Pfam SNARE associated Golgi protein
HHM66_RS05455	COG0539	negative regulation of cytoplasmic translation
HHM66_RS05475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHM66_RS05495	COG0187	DNA topoisomerase II activity
HHM66_RS05515	COG0765	amino acid transport
HHM66_RS05530	COG2801	Transposase and inactivated derivatives
HHM66_RS05570	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HHM66_RS05595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHM66_RS05605	COG0028	Belongs to the TPP enzyme family
HHM66_RS05610	COG0028	Belongs to the TPP enzyme family
HHM66_RS05620	COG0028	Belongs to the TPP enzyme family
HHM66_RS05635	COG1012	belongs to the aldehyde dehydrogenase family
HHM66_RS05640	COG1011	Hydrolase
HHM66_RS05650	COG0701	Predicted permease
HHM66_RS05665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHM66_RS05680	COG2207	Transcriptional regulator
HHM66_RS05680	COG4753	response regulator
HHM66_RS05685	COG2972	Histidine kinase
HHM66_RS05690	COG3716	PTS system mannose fructose sorbose family IID component
HHM66_RS05695	COG3715	PTS system
HHM66_RS05760	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HHM66_RS05765	COG1518	maintenance of DNA repeat elements
HHM66_RS05780	COG0647	UMP catabolic process
HHM66_RS05790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHM66_RS05810	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HHM66_RS05815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHM66_RS05820	COG3442	glutamine amidotransferase
HHM66_RS05825	COG0095	Lipoate-protein ligase
HHM66_RS05835	COG1695	Transcriptional regulator
HHM66_RS05845	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHM66_RS05850	COG0022	dehydrogenase e1 component
HHM66_RS05850	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHM66_RS05855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHM66_RS05860	COG0488	(ABC) transporter
HHM66_RS05880	COG1122	ATPase activity
HHM66_RS05910	COG3700	Belongs to the class B bacterial acid phosphatase family
HHM66_RS05930	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HHM66_RS05935	COG0457	Tetratricopeptide repeat
HHM66_RS05940	COG0628	permease
HHM66_RS05945	COG1051	belongs to the nudix hydrolase family
HHM66_RS05960	COG1088	dTDP-glucose 4,6-dehydratase activity
HHM66_RS05970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HHM66_RS05975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHM66_RS05990	COG2384	SAM-dependent methyltransferase
HHM66_RS05995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHM66_RS06010	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HHM66_RS06010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHM66_RS06015	COG0300	oxidoreductase activity
HHM66_RS06030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHM66_RS06075	COG0431	NADPH-dependent FMN reductase
HHM66_RS06080	COG0058	SHG alpha-glucan phosphorylase activity
HHM66_RS06085	COG1640	4-alpha-glucanotransferase
HHM66_RS06090	COG1609	Transcriptional regulator
HHM66_RS06100	COG2182	Extracellular solute-binding protein
HHM66_RS06110	COG3833	ABC-type maltose transport systems, permease component
HHM66_RS06135	COG0366	Alpha amylase catalytic
HHM66_RS06140	COG2182	Extracellular solute-binding protein
HHM66_RS06145	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HHM66_RS06155	COG1696	Membrane protein involved in D-alanine export
HHM66_RS06175	COG0765	amino acid transport
HHM66_RS06180	COG1126	abc transporter atp-binding protein
HHM66_RS06205	COG2309	aminopeptidase activity
HHM66_RS06220	COG1187	pseudouridine synthase activity
HHM66_RS06230	COG2814	Major facilitator Superfamily
HHM66_RS06240	COG0390	transport system, permease component
HHM66_RS06245	COG4619	ABC transporter
HHM66_RS06315	COG0534	Mate efflux family protein
HHM66_RS06320	COG1129	ABC transporter
HHM66_RS06335	COG1132	(ABC) transporter
HHM66_RS06345	COG1309	transcriptional regulator
HHM66_RS06410	COG0551	DNA topoisomerase type I activity
HHM66_RS06410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HHM66_RS06510	COG1129	ABC transporter
HHM66_RS06515	COG1132	(ABC) transporter
HHM66_RS06520	COG1132	(ABC) transporter
HHM66_RS06560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHM66_RS06590	COG4109	DRTGG domain
HHM66_RS06615	COG1028	Short-chain dehydrogenase reductase Sdr
HHM66_RS06630	COG0800	Aldolase
HHM66_RS06635	COG2186	Transcriptional regulator
HHM66_RS06640	COG3250	beta-galactosidase activity
HHM66_RS06650	COG2211	Major facilitator Superfamily
HHM66_RS06670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HHM66_RS06670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HHM66_RS06680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHM66_RS06685	COG1956	GAF domain-containing protein
HHM66_RS06705	COG0513	Belongs to the DEAD box helicase family
HHM66_RS06710	COG0726	polysaccharide deacetylase
HHM66_RS06730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHM66_RS06735	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHM66_RS06740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HHM66_RS06760	COG1476	TRANSCRIPTIONal
HHM66_RS06780	COG4122	O-methyltransferase activity
HHM66_RS06785	COG2223	nitrite transmembrane transporter activity
HHM66_RS06800	COG0431	NADPH-dependent FMN reductase
HHM66_RS06820	COG1187	pseudouridine synthase activity
HHM66_RS06855	COG2333	competence protein COMEC
HHM66_RS06855	COG0658	competence protein
HHM66_RS06860	COG1596	polysaccharide export
HHM66_RS06860	COG1555	photosystem II stabilization
HHM66_RS06865	COG0204	Acyl-transferase
HHM66_RS06870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HHM66_RS06885	COG0513	Belongs to the DEAD box helicase family
HHM66_RS06890	COG1464	Belongs to the NlpA lipoprotein family
HHM66_RS06900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHM66_RS06920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HHM66_RS06935	COG0768	penicillin binding
HHM66_RS06940	COG2116	formate transmembrane transporter activity
HHM66_RS06950	COG1827	regulation of RNA biosynthetic process
HHM66_RS06970	COG2217	Heavy metal translocating P-type atpase
HHM66_RS06995	COG2755	lipolytic protein G-D-S-L family
HHM66_RS07010	COG0497	DNA recombination
HHM66_RS07015	COG1438	arginine binding
HHM66_RS07020	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HHM66_RS07050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHM66_RS07080	COG0765	amino acid transport
HHM66_RS07085	COG4703	Protein of unknown function (DUF1797)
HHM66_RS07090	COG0542	response to heat
HHM66_RS07095	COG1051	belongs to the nudix hydrolase family
HHM66_RS07110	COG3599	regulation of cell shape
HHM66_RS07130	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HHM66_RS07140	COG0849	cell division
HHM66_RS07175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HHM66_RS07180	COG1940	carbohydrate kinase activity
HHM66_RS07190	COG0783	Belongs to the Dps family
HHM66_RS07200	COG1132	(ABC) transporter
HHM66_RS07205	COG1132	(ABC) transporter
HHM66_RS07215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HHM66_RS07220	COG4470	Protein conserved in bacteria
HHM66_RS07235	COG1879	ABC-type sugar transport system periplasmic component
HHM66_RS07240	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHM66_RS07250	COG1869	D-ribose catabolic process
HHM66_RS07255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHM66_RS07260	COG1609	Transcriptional regulator
HHM66_RS07265	COG3480	Lon protease (S16) C-terminal proteolytic domain
HHM66_RS07275	COG0742	ribosomal rna small subunit methyltransferase
HHM66_RS07285	COG0549	Belongs to the carbamate kinase family
HHM66_RS07295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHM66_RS07300	COG1288	antiporter activity
HHM66_RS07310	COG0454	-acetyltransferase
HHM66_RS07315	COG2235	arginine
HHM66_RS07320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHM66_RS07340	COG2972	Histidine kinase
HHM66_RS07355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHM66_RS07360	COG0785	Cytochrome C biogenesis protein
HHM66_RS07370	COG0673	inositol 2-dehydrogenase activity
HHM66_RS07375	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HHM66_RS07380	COG1518	maintenance of DNA repeat elements
HHM66_RS07410	COG5433	transposase activity
HHM66_RS07430	COG0346	lactoylglutathione lyase activity
HHM66_RS07495	COG0433	COG0433 Predicted ATPase
HHM66_RS07540	COG1396	sequence-specific DNA binding
HHM66_RS07555	COG1674	ftsk spoiiie
HHM66_RS07595	COG1396	sequence-specific DNA binding
HHM66_RS07635	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HHM66_RS07635	COG1605	Chorismate mutase
HHM66_RS07670	COG3250	beta-galactosidase activity
HHM66_RS07675	COG4753	response regulator
HHM66_RS07675	COG2207	Transcriptional regulator
HHM66_RS07680	COG2972	Histidine kinase
HHM66_RS07695	COG0395	ABC-type sugar transport system, permease component
HHM66_RS07700	COG1175	transmembrane transport
HHM66_RS07720	COG2723	6-phospho-beta-galactosidase activity
HHM66_RS07725	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HHM66_RS07740	COG0383	alpha-mannosidase activity
HHM66_RS07760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHM66_RS07770	COG2070	2-Nitropropane dioxygenase
HHM66_RS07780	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHM66_RS07780	COG1024	Enoyl-CoA hydratase
HHM66_RS07945	COG5484	DNA packaging
HHM66_RS08090	COG3561	AntA/AntB antirepressor
HHM66_RS08115	COG3620	sequence-specific DNA binding
HHM66_RS08210	COG1040	competence protein
HHM66_RS08215	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HHM66_RS08220	COG1739	Uncharacterized protein family UPF0029
HHM66_RS08230	COG1098	S1 RNA binding domain
HHM66_RS08240	COG2197	response regulator
HHM66_RS08245	COG4585	Histidine kinase
HHM66_RS08255	COG0515	serine threonine protein kinase
HHM66_RS08255	COG2815	serine threonine protein kinase
HHM66_RS08265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHM66_RS08265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHM66_RS08275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHM66_RS08295	COG0583	DNA-binding transcription factor activity
HHM66_RS08300	COG0183	Belongs to the thiolase family
HHM66_RS08305	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HHM66_RS08335	COG0116	Belongs to the methyltransferase superfamily
HHM66_RS08355	COG5433	transposase activity
HHM66_RS08365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHM66_RS08370	COG3579	cysteine-type endopeptidase activity
HHM66_RS08380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HHM66_RS08385	COG1113	amino acid transport
HHM66_RS08390	COG0492	ferredoxin-NADP+ reductase activity
HHM66_RS08400	COG1126	abc transporter atp-binding protein
HHM66_RS08405	COG0765	amino acid transport
HHM66_RS08415	COG0513	Belongs to the DEAD box helicase family
HHM66_RS08425	COG0768	penicillin binding
HHM66_RS08455	COG1131	(ABC) transporter
HHM66_RS08480	COG0446	pyridine nucleotide-disulphide oxidoreductase
HHM66_RS08485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHM66_RS08520	COG1755	Isoprenylcysteine carboxyl methyltransferase
HHM66_RS08525	COG0656	L-ascorbic acid biosynthetic process
HHM66_RS08535	COG1283	sodium-dependent phosphate transmembrane transporter activity
HHM66_RS08555	COG0561	phosphatase activity
HHM66_RS08560	COG2860	membrane
HHM66_RS08570	COG1105	Belongs to the carbohydrate kinase PfkB family
HHM66_RS08595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHM66_RS08610	COG2217	Heavy metal translocating P-type atpase
HHM66_RS08640	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HHM66_RS08645	COG0195	Participates in both transcription termination and antitermination
HHM66_RS08670	COG4473	ABC transporter
HHM66_RS08675	COG1131	(ABC) transporter
HHM66_RS08680	COG0537	adenosine 5'-monophosphoramidase activity
HHM66_RS08690	COG1316	TRANSCRIPTIONal
HHM66_RS08695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHM66_RS08700	COG0802	atpase or kinase
HHM66_RS08705	COG2252	PERMEase
HHM66_RS08710	COG0561	phosphatase activity
HHM66_RS08720	COG3715	PTS system
HHM66_RS08725	COG3716	PTS system mannose fructose sorbose family IID component
HHM66_RS08755	COG0439	Biotin carboxylase
HHM66_RS08770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HHM66_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
HHM66_RS08780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HHM66_RS08785	COG2070	2-Nitropropane dioxygenase
HHM66_RS08805	COG1024	Enoyl-CoA hydratase
HHM66_RS08810	COG0484	heat shock protein binding
HHM66_RS08830	COG1420	regulation of RNA biosynthetic process
HHM66_RS08850	COG0588	phosphoglycerate mutase activity
HHM66_RS08855	COG2261	transglycosylase associated protein
HHM66_RS08880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHM66_RS08880	COG0574	Belongs to the PEP-utilizing enzyme family
HHM66_RS08885	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HHM66_RS08890	COG0517	IMP dehydrogenase activity
HHM66_RS08900	COG0446	pyridine nucleotide-disulphide oxidoreductase
HHM66_RS08910	COG1937	Protein conserved in bacteria
HHM66_RS08915	COG1335	isochorismatase
HHM66_RS08925	COG0436	Aminotransferase
HHM66_RS08935	COG0561	phosphatase activity
HHM66_RS08940	COG0252	asparaginase activity
HHM66_RS08945	COG4989	oxidoreductase activity
HHM66_RS08950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HHM66_RS08955	COG1129	ABC transporter
HHM66_RS08970	COG1132	(ABC) transporter
HHM66_RS08975	COG4988	ABC transporter
HHM66_RS08980	COG1120	ATPase activity
HHM66_RS09005	COG1388	LysM domain
HHM66_RS09005	COG3942	CHAP domain
HHM66_RS09025	COG1482	cell wall glycoprotein biosynthetic process
HHM66_RS09030	COG1940	carbohydrate kinase activity
HHM66_RS09035	COG2190	(PTS) system
HHM66_RS09035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM66_RS09035	COG1263	PTS System
HHM66_RS09040	COG1621	beta-fructofuranosidase activity
HHM66_RS09045	COG1609	Transcriptional regulator
HHM66_RS09065	COG2131	deaminase
HHM66_RS09070	COG0006	proline dipeptidase activity
HHM66_RS09110	COG1194	a g-specific adenine glycosylase
HHM66_RS09120	COG3118	belongs to the thioredoxin family
HHM66_RS09125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHM66_RS09150	COG0681	Belongs to the peptidase S26 family
HHM66_RS09155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HHM66_RS09170	COG1882	Formate acetyltransferase
HHM66_RS09175	COG2153	protein acetylation
HHM66_RS09185	COG1653	transport
HHM66_RS09195	COG0395	ABC-type sugar transport system, permease component
HHM66_RS09200	COG4209	transmembrane transport
HHM66_RS09210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HHM66_RS09225	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HHM66_RS09255	COG0789	Transcriptional regulator
HHM66_RS09270	COG2081	HI0933 family
HHM66_RS09305	COG1214	PFAM Peptidase M22, glycoprotease
HHM66_RS09320	COG4608	Belongs to the ABC transporter superfamily
HHM66_RS09325	COG0444	Belongs to the ABC transporter superfamily
HHM66_RS09330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHM66_RS09335	COG0601	transmembrane transport
HHM66_RS09340	COG4166	transmembrane transport
HHM66_RS09345	COG0174	glutamine synthetase
HHM66_RS09350	COG0789	Transcriptional regulator
HHM66_RS09365	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
HHM66_RS09395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHM66_RS09410	COG1564	THIamine pyrophosphokinase
HHM66_RS09435	COG0084	hydrolase, TatD family'
HHM66_RS09445	COG1335	isochorismatase
HHM66_RS09460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHM66_RS09475	COG0395	ABC-type sugar transport system, permease component
HHM66_RS09480	COG1175	transmembrane transport
HHM66_RS09500	COG1847	R3H domain protein
HHM66_RS09565	COG0756	dUTP diphosphatase activity
HHM66_RS09575	COG1132	(ABC) transporter
HHM66_RS09580	COG1132	(ABC) transporter
HHM66_RS09595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HHM66_RS09605	COG0457	Tetratricopeptide repeat
HHM66_RS09605	COG0705	Rhomboid family
HHM66_RS09610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HHM66_RS09650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHM66_RS09680	COG1234	tRNA 3'-trailer cleavage
HHM66_RS09685	COG1268	BioY protein
HHM66_RS09710	COG1832	CoA-binding protein
HHM66_RS09715	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHM66_RS09715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHM66_RS09725	COG4175	Glycine betaine
HHM66_RS09725	COG3448	diguanylate cyclase activity
HHM66_RS09730	COG1597	lipid kinase activity
HHM66_RS09750	COG3623	hexulose-6-phosphate isomerase
HHM66_RS09860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHM66_RS09875	COG0564	pseudouridine synthase activity
HHM66_RS09905	COG0542	response to heat
HHM66_RS09910	COG4463	regulation of RNA biosynthetic process
HHM66_RS09940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHM66_RS09960	COG4974	Belongs to the 'phage' integrase family
HHM66_RS09975	COG1396	sequence-specific DNA binding
HHM66_RS10010	COG0305	Participates in initiation and elongation during chromosome replication
HHM66_RS10080	COG0582	viral genome integration into host DNA
HHM66_RS10205	COG0450	alkyl hydroperoxide reductase
HHM66_RS10220	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HHM66_RS10230	COG3404	Formiminotransferase-cyclodeaminase
HHM66_RS10245	COG0531	amino acid
HHM66_RS10275	COG3590	peptidase
HHM66_RS10280	COG0366	Alpha amylase catalytic
HHM66_RS10285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HHM66_RS10285	COG1263	PTS System
HHM66_RS10290	COG2188	Transcriptional regulator
HHM66_RS10310	COG0602	queuosine metabolic process
HHM66_RS10350	COG4472	Bacterial protein of unknown function (DUF965)
HHM66_RS10355	COG1393	Belongs to the ArsC family
HHM66_RS10380	COG0519	Catalyzes the synthesis of GMP from XMP
HHM66_RS10390	COG2814	Major facilitator Superfamily
HHM66_RS10425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHM66_RS10430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHM66_RS10435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHM66_RS10515	COG1511	domain protein
HHM66_RS10655	COG0582	viral genome integration into host DNA
HHM66_RS10660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHM66_RS10665	COG5433	transposase activity
HHM66_RS10680	COG0305	Participates in initiation and elongation during chromosome replication
HHM66_RS10705	COG2095	MarC family integral membrane protein
HHM66_RS10715	COG1760	l-serine dehydratase
HHM66_RS10720	COG1760	l-serine dehydratase
HHM66_RS10730	COG0741	lytic transglycosylase activity
HHM66_RS10750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHM66_RS10760	COG0612	Peptidase, M16
HHM66_RS10785	COG0517	IMP dehydrogenase activity
HHM66_RS10785	COG0516	GMP reductase activity
HHM66_RS10795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HHM66_RS10800	COG0488	(ABC) transporter
HHM66_RS10835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain