locus-tag	class	description
SESEC_RS00010	COG0592	DNA-directed DNA polymerase activity
SESEC_RS00025	COG0012	GTP binding
SESEC_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
SESEC_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SESEC_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SESEC_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SESEC_RS00075	COG0531	amino acid
SESEC_RS00195	COG3942	CHAP domain
SESEC_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SESEC_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SESEC_RS00255	COG0151	Belongs to the GarS family
SESEC_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SESEC_RS00275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SESEC_RS00290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SESEC_RS00305	COG1454	alcohol dehydrogenase
SESEC_RS00305	COG1012	belongs to the aldehyde dehydrogenase family
SESEC_RS00310	COG1063	alcohol dehydrogenase
SESEC_RS00315	COG1064	alcohol dehydrogenase
SESEC_RS00325	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SESEC_RS00335	COG0051	transcription antitermination factor activity, RNA binding
SESEC_RS00350	COG0089	rRNA binding
SESEC_RS00435	COG0201	protein transport
SESEC_RS00440	COG0563	adenylate kinase activity
SESEC_RS00585	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SESEC_RS00600	COG1121	(ABC) transporter
SESEC_RS00605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SESEC_RS00615	COG4499	WXG100 protein secretion system (Wss), protein YukC
SESEC_RS00615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SESEC_RS00620	COG0085	RNA polymerase activity
SESEC_RS00625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SESEC_RS00665	COG1136	(ABC) transporter
SESEC_RS00670	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SESEC_RS00675	COG1459	type II secretion system
SESEC_RS00720	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SESEC_RS00735	COG3959	Transketolase, thiamine diphosphate binding domain
SESEC_RS00740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SESEC_RS00745	COG3590	peptidase
SESEC_RS00750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SESEC_RS00765	COG0450	alkyl hydroperoxide reductase
SESEC_RS00780	COG4463	regulation of RNA biosynthetic process
SESEC_RS00830	COG1051	belongs to the nudix hydrolase family
SESEC_RS00835	COG1396	sequence-specific DNA binding
SESEC_RS00855	COG1116	anion transmembrane transporter activity
SESEC_RS00875	COG0564	pseudouridine synthase activity
SESEC_RS00895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SESEC_RS00950	COG3623	hexulose-6-phosphate isomerase
SESEC_RS00970	COG4175	Glycine betaine
SESEC_RS00970	COG3448	diguanylate cyclase activity
SESEC_RS00980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SESEC_RS00980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SESEC_RS00985	COG1832	CoA-binding protein
SESEC_RS01030	COG1268	BioY protein
SESEC_RS01035	COG1234	tRNA 3'-trailer cleavage
SESEC_RS01055	COG1215	transferase activity, transferring glycosyl groups
SESEC_RS01085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SESEC_RS01085	COG3711	transcriptional antiterminator
SESEC_RS01095	COG3730	PTS system glucitol sorbitol-specific
SESEC_RS01100	COG3732	PTS system glucitol sorbitol-specific
SESEC_RS01125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SESEC_RS01130	COG0705	Rhomboid family
SESEC_RS01130	COG0457	Tetratricopeptide repeat
SESEC_RS01140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SESEC_RS01150	COG1132	(ABC) transporter
SESEC_RS01155	COG1132	(ABC) transporter
SESEC_RS01165	COG5433	transposase activity
SESEC_RS01170	COG0756	dUTP diphosphatase activity
SESEC_RS01230	COG1847	R3H domain protein
SESEC_RS01295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SESEC_RS01295	COG2190	(PTS) system
SESEC_RS01295	COG1263	PTS System
SESEC_RS01300	COG1263	PTS System
SESEC_RS01300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SESEC_RS01300	COG2190	(PTS) system
SESEC_RS01320	COG1175	transmembrane transport
SESEC_RS01325	COG0395	ABC-type sugar transport system, permease component
SESEC_RS01330	COG2731	YhcH YjgK YiaL family protein
SESEC_RS01340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SESEC_RS01350	COG3458	cephalosporin-C deacetylase activity
SESEC_RS01355	COG1737	Transcriptional regulator
SESEC_RS01360	COG0084	hydrolase, TatD family'
SESEC_RS01390	COG1564	THIamine pyrophosphokinase
SESEC_RS01405	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SESEC_RS01435	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SESEC_RS01440	COG0126	phosphoglycerate kinase activity
SESEC_RS01450	COG0789	Transcriptional regulator
SESEC_RS01455	COG0174	glutamine synthetase
SESEC_RS01460	COG4166	transmembrane transport
SESEC_RS01465	COG0601	transmembrane transport
SESEC_RS01470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SESEC_RS01475	COG0444	Belongs to the ABC transporter superfamily
SESEC_RS01480	COG4608	Belongs to the ABC transporter superfamily
SESEC_RS01495	COG1214	PFAM Peptidase M22, glycoprotease
SESEC_RS01510	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SESEC_RS01520	COG2081	HI0933 family
SESEC_RS01535	COG0789	Transcriptional regulator
SESEC_RS01540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SESEC_RS01555	COG5002	protein histidine kinase activity
SESEC_RS01595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SESEC_RS01600	COG2814	Major facilitator Superfamily
SESEC_RS01610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SESEC_RS01620	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SESEC_RS01630	COG1882	Formate acetyltransferase
SESEC_RS01650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SESEC_RS01655	COG0681	Belongs to the peptidase S26 family
SESEC_RS01670	COG1286	toxin biosynthetic process
SESEC_RS01680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SESEC_RS01685	COG3118	belongs to the thioredoxin family
SESEC_RS01705	COG1194	a g-specific adenine glycosylase
SESEC_RS01745	COG0006	proline dipeptidase activity
SESEC_RS01750	COG2131	deaminase
SESEC_RS01765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SESEC_RS01795	COG1609	Transcriptional regulator
SESEC_RS01800	COG1621	beta-fructofuranosidase activity
SESEC_RS01805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SESEC_RS01805	COG2190	(PTS) system
SESEC_RS01805	COG1263	PTS System
SESEC_RS01815	COG1940	carbohydrate kinase activity
SESEC_RS01820	COG1482	cell wall glycoprotein biosynthetic process
SESEC_RS01825	COG0653	protein targeting
SESEC_RS01840	COG1388	LysM domain
SESEC_RS01840	COG3942	CHAP domain
SESEC_RS01865	COG1120	ATPase activity
SESEC_RS01870	COG4988	ABC transporter
SESEC_RS01875	COG1132	(ABC) transporter
SESEC_RS01890	COG1129	ABC transporter
SESEC_RS01895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SESEC_RS01900	COG0252	asparaginase activity
SESEC_RS01905	COG0561	phosphatase activity
SESEC_RS01915	COG0436	Aminotransferase
SESEC_RS01920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SESEC_RS01925	COG1335	isochorismatase
SESEC_RS01940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SESEC_RS01945	COG0697	spore germination
SESEC_RS01950	COG2261	transglycosylase associated protein
SESEC_RS01960	COG3830	Belongs to the UPF0237 family
SESEC_RS01970	COG0588	phosphoglycerate mutase activity
SESEC_RS01975	COG1876	peptidase activity
SESEC_RS01985	COG1420	regulation of RNA biosynthetic process
SESEC_RS01995	COG0443	Heat shock 70 kDa protein
SESEC_RS02000	COG0484	heat shock protein binding
SESEC_RS02005	COG1024	Enoyl-CoA hydratase
SESEC_RS02015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SESEC_RS02025	COG2070	2-Nitropropane dioxygenase
SESEC_RS02030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SESEC_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
SESEC_RS02040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SESEC_RS02055	COG0439	Biotin carboxylase
SESEC_RS02060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SESEC_RS02085	COG3716	PTS system mannose fructose sorbose family IID component
SESEC_RS02090	COG3715	PTS system
SESEC_RS02105	COG0561	phosphatase activity
SESEC_RS02110	COG2252	PERMEase
SESEC_RS02115	COG0802	atpase or kinase
SESEC_RS02125	COG1316	TRANSCRIPTIONal
SESEC_RS02135	COG0537	adenosine 5'-monophosphoramidase activity
SESEC_RS02145	COG1131	(ABC) transporter
SESEC_RS02150	COG4473	ABC transporter
SESEC_RS02160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SESEC_RS02185	COG0195	Participates in both transcription termination and antitermination
SESEC_RS02190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SESEC_RS02225	COG2217	Heavy metal translocating P-type atpase
SESEC_RS02260	COG1105	Belongs to the carbohydrate kinase PfkB family
SESEC_RS02270	COG3711	transcriptional antiterminator
SESEC_RS02275	COG1447	Phosphotransferase system cellobiose-specific component IIA
SESEC_RS02280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SESEC_RS02280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SESEC_RS02285	COG2723	6-phospho-beta-galactosidase activity
SESEC_RS02295	COG2860	membrane
SESEC_RS02300	COG0561	phosphatase activity
SESEC_RS02315	COG1609	Transcriptional regulator
SESEC_RS02320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SESEC_RS02325	COG1869	D-ribose catabolic process
SESEC_RS02335	COG1172	Belongs to the binding-protein-dependent transport system permease family
SESEC_RS02340	COG1879	ABC-type sugar transport system periplasmic component
SESEC_RS02360	COG1283	sodium-dependent phosphate transmembrane transporter activity
SESEC_RS02370	COG0656	L-ascorbic acid biosynthetic process
SESEC_RS02395	COG1755	Isoprenylcysteine carboxyl methyltransferase
SESEC_RS02405	COG0751	glycine-tRNA ligase activity
SESEC_RS02440	COG1131	(ABC) transporter
SESEC_RS02480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SESEC_RS02485	COG1393	Belongs to the ArsC family
SESEC_RS02490	COG0708	Exodeoxyribonuclease III
SESEC_RS02555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SESEC_RS02575	COG1114	Component of the transport system for branched-chain amino acids
SESEC_RS02700	COG1518	maintenance of DNA repeat elements
SESEC_RS02705	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SESEC_RS02720	COG0785	Cytochrome C biogenesis protein
SESEC_RS02725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SESEC_RS02735	COG2207	Transcriptional regulator
SESEC_RS02735	COG4753	response regulator
SESEC_RS02740	COG2972	Histidine kinase
SESEC_RS02745	COG2315	Protein conserved in bacteria
SESEC_RS02775	COG0454	-acetyltransferase
SESEC_RS02785	COG1288	antiporter activity
SESEC_RS02790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SESEC_RS02795	COG0549	Belongs to the carbamate kinase family
SESEC_RS02805	COG0742	ribosomal rna small subunit methyltransferase
SESEC_RS02810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SESEC_RS02815	COG3480	Lon protease (S16) C-terminal proteolytic domain
SESEC_RS02820	COG4470	Protein conserved in bacteria
SESEC_RS02835	COG0783	Belongs to the Dps family
SESEC_RS02840	COG4483	Protein conserved in bacteria
SESEC_RS02845	COG1940	carbohydrate kinase activity
SESEC_RS02855	COG1217	gtp-binding protein TYPA
SESEC_RS02880	COG0849	cell division
SESEC_RS02890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SESEC_RS02910	COG3599	regulation of cell shape
SESEC_RS02925	COG0494	nUDIX hydrolase
SESEC_RS02930	COG0542	response to heat
SESEC_RS02935	COG4703	Protein of unknown function (DUF1797)
SESEC_RS02945	COG0765	amino acid transport
SESEC_RS02950	COG1126	abc transporter atp-binding protein
SESEC_RS02955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SESEC_RS02960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SESEC_RS02965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SESEC_RS02985	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SESEC_RS02990	COG1438	arginine binding
SESEC_RS02995	COG0497	DNA recombination
SESEC_RS03010	COG2755	lipolytic protein G-D-S-L family
SESEC_RS03015	COG4698	Protein conserved in bacteria
SESEC_RS03040	COG1396	sequence-specific DNA binding
SESEC_RS03050	COG0167	dihydroorotate dehydrogenase activity
SESEC_RS03060	COG1827	regulation of RNA biosynthetic process
SESEC_RS03070	COG2116	formate transmembrane transporter activity
SESEC_RS03075	COG0768	penicillin binding
SESEC_RS03090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SESEC_RS03110	COG0513	Belongs to the DEAD box helicase family
SESEC_RS03125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SESEC_RS03130	COG0204	Acyl-transferase
SESEC_RS03140	COG0658	competence protein
SESEC_RS03140	COG2333	competence protein COMEC
SESEC_RS03175	COG1187	pseudouridine synthase activity
SESEC_RS03200	COG0546	phosphoglycolate phosphatase activity
SESEC_RS03205	COG4122	O-methyltransferase activity
SESEC_RS03210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SESEC_RS03225	COG0726	polysaccharide deacetylase
SESEC_RS03230	COG0513	Belongs to the DEAD box helicase family
SESEC_RS03250	COG1956	GAF domain-containing protein
SESEC_RS03255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SESEC_RS03265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SESEC_RS03265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SESEC_RS03290	COG5433	transposase activity
SESEC_RS03305	COG2211	Major facilitator Superfamily
SESEC_RS03315	COG3250	beta-galactosidase activity
SESEC_RS03320	COG2186	Transcriptional regulator
SESEC_RS03325	COG0800	Aldolase
SESEC_RS03330	COG1904	glucuronate isomerase
SESEC_RS03340	COG1028	Short-chain dehydrogenase reductase Sdr
SESEC_RS03360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SESEC_RS03365	COG4109	DRTGG domain
SESEC_RS03370	COG0024	Methionine aminopeptidase
SESEC_RS03380	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SESEC_RS03390	COG1316	TRANSCRIPTIONal
SESEC_RS03400	COG2274	protein secretion by the type I secretion system
SESEC_RS03405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SESEC_RS03490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SESEC_RS03490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SESEC_RS03535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SESEC_RS03590	COG4695	Portal protein
SESEC_RS03595	COG0740	serine-type endopeptidase activity
SESEC_RS03805	COG1373	ATPase (AAA superfamily
SESEC_RS03815	COG0588	phosphoglycerate mutase activity
SESEC_RS03825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SESEC_RS03830	COG3859	Proton-coupled thiamine transporter YuaJ
SESEC_RS03850	COG0386	Belongs to the glutathione peroxidase family
SESEC_RS03855	COG1164	Oligoendopeptidase f
SESEC_RS03865	COG0772	Belongs to the SEDS family
SESEC_RS03875	COG1131	(ABC) transporter
SESEC_RS03890	COG2274	protein secretion by the type I secretion system
SESEC_RS03900	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SESEC_RS03905	COG2884	Cell division ATP-binding protein ftsE
SESEC_RS03910	COG2177	Part of the ABC transporter FtsEX involved in
SESEC_RS03920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SESEC_RS03920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SESEC_RS03920	COG1199	ATP-dependent helicase activity
SESEC_RS03920	COG1199	ATP-dependent helicase activity
SESEC_RS03930	COG0436	Aminotransferase
SESEC_RS03935	COG0017	Asparaginyl-tRNA synthetase
SESEC_RS03975	COG2188	Transcriptional regulator
SESEC_RS03980	COG2222	sugar isomerase
SESEC_RS03985	COG3684	Belongs to the aldolase LacD family
SESEC_RS03990	COG2188	Transcriptional regulator
SESEC_RS04000	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SESEC_RS04000	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SESEC_RS04005	COG3715	PTS system
SESEC_RS04010	COG3716	PTS system mannose fructose sorbose family IID component
SESEC_RS04025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SESEC_RS04030	COG2153	protein acetylation
SESEC_RS04040	COG0716	FMN binding
SESEC_RS04050	COG0038	chloride channel
SESEC_RS04070	COG1476	TRANSCRIPTIONal
SESEC_RS04090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SESEC_RS04095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SESEC_RS04100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SESEC_RS04110	COG1012	belongs to the aldehyde dehydrogenase family
SESEC_RS04120	COG0772	Belongs to the SEDS family
SESEC_RS04170	COG4708	membrane
SESEC_RS04180	COG1597	lipid kinase activity
SESEC_RS04185	COG1523	belongs to the glycosyl hydrolase 13 family
SESEC_RS04190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SESEC_RS04195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SESEC_RS04200	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SESEC_RS04210	COG0058	SHG alpha-glucan phosphorylase activity
SESEC_RS04290	COG0577	efflux transmembrane transporter activity
SESEC_RS04305	COG1309	transcriptional regulator
SESEC_RS04355	COG1523	belongs to the glycosyl hydrolase 13 family
SESEC_RS04360	COG1595	DNA-templated transcription, initiation
SESEC_RS04400	COG1074	ATP-dependent DNA helicase activity
SESEC_RS04405	COG0436	Aminotransferase
SESEC_RS04410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SESEC_RS04420	COG1970	mechanosensitive ion channel activity
SESEC_RS04425	COG0358	DNA primase activity
SESEC_RS04430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SESEC_RS04435	COG2151	metal-sulfur cluster biosynthetic enzyme
SESEC_RS04440	COG1091	dTDP-4-dehydrorhamnose reductase activity
SESEC_RS04450	COG1215	transferase activity, transferring glycosyl groups
SESEC_RS04475	COG0463	Glycosyl transferase, family 2
SESEC_RS04495	COG0297	glycogen (starch) synthase activity
SESEC_RS04500	COG1368	sulfuric ester hydrolase activity
SESEC_RS04505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SESEC_RS04560	COG1368	sulfuric ester hydrolase activity
SESEC_RS04565	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SESEC_RS04580	COG3679	Belongs to the UPF0342 family
SESEC_RS04585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SESEC_RS04595	COG1104	cysteine desulfurase activity
SESEC_RS04600	COG0301	tRNA thio-modification
SESEC_RS04635	COG1131	(ABC) transporter
SESEC_RS04640	COG1725	Transcriptional regulator
SESEC_RS04655	COG0469	pyruvate kinase activity
SESEC_RS04670	COG2824	Alkylphosphonate utilization operon protein PhnA
SESEC_RS04675	COG0765	amino acid transport
SESEC_RS04680	COG1126	abc transporter atp-binding protein
SESEC_RS04685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SESEC_RS04690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SESEC_RS04695	COG1115	amino acid carrier protein
SESEC_RS04745	COG4591	ABC-type transport system involved in lipoprotein release permease component
SESEC_RS04745	COG1136	(ABC) transporter
SESEC_RS04775	COG0196	riboflavin kinase activity
SESEC_RS04790	COG0483	inositol monophosphate 1-phosphatase activity
SESEC_RS04795	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SESEC_RS04795	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SESEC_RS04805	COG0573	inorganic phosphate transmembrane transporter activity
SESEC_RS04810	COG0581	inorganic phosphate transmembrane transporter activity
SESEC_RS04825	COG0704	Plays a role in the regulation of phosphate uptake
SESEC_RS04835	COG0745	RESPONSE REGULATOR receiver
SESEC_RS04840	COG5002	protein histidine kinase activity
SESEC_RS04900	COG1072	(Pantothenic acid kinase))
SESEC_RS04905	COG2813	Specifically methylates the guanine in position
SESEC_RS04910	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SESEC_RS04925	COG1744	ABC transporter substrate-binding protein PnrA-like
SESEC_RS04930	COG3845	ABC transporter
SESEC_RS04935	COG4603	Belongs to the binding-protein-dependent transport system permease family
SESEC_RS04940	COG1079	Belongs to the binding-protein-dependent transport system permease family
SESEC_RS04945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SESEC_RS04950	COG4684	Psort location CytoplasmicMembrane, score
SESEC_RS04955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SESEC_RS04965	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SESEC_RS04975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SESEC_RS04980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SESEC_RS04985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SESEC_RS04985	COG1328	CTP reductase activity
SESEC_RS04990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SESEC_RS05005	COG0488	(ABC) transporter
SESEC_RS05015	COG1597	lipid kinase activity
SESEC_RS05020	COG1272	protein, Hemolysin III
SESEC_RS05030	COG2226	methyltransferase
SESEC_RS05055	COG1131	(ABC) transporter
SESEC_RS05090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SESEC_RS05100	COG0758	DNA mediated transformation
SESEC_RS05105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SESEC_RS05125	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SESEC_RS05145	COG2851	Citrate transporter
SESEC_RS05155	COG0511	ligase activity, forming carbon-carbon bonds
SESEC_RS05160	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SESEC_RS05200	COG1136	(ABC) transporter
SESEC_RS05205	COG0577	efflux transmembrane transporter activity
SESEC_RS05210	COG0745	RESPONSE REGULATOR receiver
SESEC_RS05215	COG5002	protein histidine kinase activity
SESEC_RS05220	COG4974	Belongs to the 'phage' integrase family
SESEC_RS05290	COG3843	relaxase mobilization nuclease domain protein
SESEC_RS05350	COG2188	Transcriptional regulator
SESEC_RS05360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SESEC_RS05380	COG0803	Belongs to the bacterial solute-binding protein 9 family
SESEC_RS05385	COG0346	lactoylglutathione lyase activity
SESEC_RS05390	COG3764	Sortase (surface protein transpeptidase)
SESEC_RS05420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SESEC_RS05425	COG1247	-acetyltransferase
SESEC_RS05430	COG0009	L-threonylcarbamoyladenylate synthase
SESEC_RS05435	COG2890	protein-(glutamine-N5) methyltransferase activity
SESEC_RS05450	COG1942	4-Oxalocrotonate Tautomerase
SESEC_RS05470	COG1174	glycine betaine transport
SESEC_RS05485	COG4221	oxidoreductase activity
SESEC_RS05490	COG0280	phosphate acetyltransferase
SESEC_RS05495	COG0564	pseudouridine synthase activity
SESEC_RS05505	COG2357	RelA SpoT domain protein
SESEC_RS05520	COG1104	cysteine desulfurase activity
SESEC_RS05535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SESEC_RS05545	COG0628	permease
SESEC_RS05565	COG1177	transmembrane transport
SESEC_RS05570	COG1176	ABC-type spermidine putrescine transport system, permease component I
SESEC_RS05580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SESEC_RS05585	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SESEC_RS05600	COG0302	gtp cyclohydrolase
SESEC_RS05605	COG0285	dihydrofolate synthase activity
SESEC_RS05615	COG0460	homoserine dehydrogenase
SESEC_RS05620	COG0726	polysaccharide deacetylase
SESEC_RS05630	COG0105	UTP biosynthetic process
SESEC_RS05655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SESEC_RS05660	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SESEC_RS05670	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SESEC_RS05680	COG3425	synthase
SESEC_RS05710	COG1132	(ABC) transporter
SESEC_RS05715	COG1132	(ABC) transporter
SESEC_RS05720	COG0737	Belongs to the 5'-nucleotidase family
SESEC_RS05725	COG0242	peptide deformylase activity
SESEC_RS05730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SESEC_RS05745	COG0488	(ABC) transporter
SESEC_RS05765	COG1705	Flagellar rod assembly protein muramidase FlgJ
SESEC_RS05765	COG1388	LysM domain
SESEC_RS05795	COG1476	TRANSCRIPTIONal
SESEC_RS05800	COG1705	Flagellar rod assembly protein muramidase FlgJ
SESEC_RS05800	COG1388	LysM domain
SESEC_RS05805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SESEC_RS05805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SESEC_RS05805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SESEC_RS05810	COG1105	Belongs to the carbohydrate kinase PfkB family
SESEC_RS05815	COG1349	DNA-binding transcription factor activity
SESEC_RS05835	COG0336	Belongs to the RNA methyltransferase TrmD family
SESEC_RS05845	COG2801	Transposase and inactivated derivatives
SESEC_RS05865	COG1837	Belongs to the UPF0109 family
SESEC_RS05880	COG0577	efflux transmembrane transporter activity
SESEC_RS05885	COG1136	(ABC) transporter
SESEC_RS05890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SESEC_RS05895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SESEC_RS05925	COG0564	pseudouridine synthase activity
SESEC_RS05935	COG0583	DNA-binding transcription factor activity
SESEC_RS05940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SESEC_RS05985	COG2801	Transposase and inactivated derivatives
SESEC_RS05995	COG0539	negative regulation of cytoplasmic translation
SESEC_RS06015	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SESEC_RS06030	COG0187	DNA topoisomerase II activity
SESEC_RS06045	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SESEC_RS06055	COG0765	amino acid transport
SESEC_RS06060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SESEC_RS06075	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SESEC_RS06080	COG0284	orotidine-5'-phosphate decarboxylase activity
SESEC_RS06090	COG0583	DNA-binding transcription factor activity
SESEC_RS06115	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SESEC_RS06170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SESEC_RS06180	COG0322	excinuclease ABC activity
SESEC_RS06185	COG1840	ABC-type Fe3 transport system, periplasmic component
SESEC_RS06190	COG4753	response regulator
SESEC_RS06190	COG2207	Transcriptional regulator
SESEC_RS06195	COG2972	Histidine kinase
SESEC_RS06200	COG3716	PTS system mannose fructose sorbose family IID component
SESEC_RS06205	COG3715	PTS system
SESEC_RS06235	COG0481	GTPase activity
SESEC_RS06260	COG0647	UMP catabolic process
SESEC_RS06270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SESEC_RS06290	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SESEC_RS06295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SESEC_RS06300	COG3442	glutamine amidotransferase
SESEC_RS06305	COG0095	Lipoate-protein ligase
SESEC_RS06315	COG0508	dehydrogenase complex catalyzes the overall conversion of
SESEC_RS06320	COG0022	dehydrogenase e1 component
SESEC_RS06320	COG0508	dehydrogenase complex catalyzes the overall conversion of
SESEC_RS06325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SESEC_RS06330	COG0488	(ABC) transporter
SESEC_RS06345	COG1122	ATPase activity
SESEC_RS06360	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SESEC_RS06365	COG0457	Tetratricopeptide repeat
SESEC_RS06370	COG0628	permease
SESEC_RS06375	COG1051	belongs to the nudix hydrolase family
SESEC_RS06380	COG1088	dTDP-glucose 4,6-dehydratase activity
SESEC_RS06390	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SESEC_RS06395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SESEC_RS06405	COG2384	SAM-dependent methyltransferase
SESEC_RS06410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SESEC_RS06430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SESEC_RS06430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SESEC_RS06435	COG0300	oxidoreductase activity
SESEC_RS06440	COG1234	tRNA 3'-trailer cleavage
SESEC_RS06445	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SESEC_RS06450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SESEC_RS06455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SESEC_RS06465	COG0058	SHG alpha-glucan phosphorylase activity
SESEC_RS06470	COG1640	4-alpha-glucanotransferase
SESEC_RS06475	COG1609	Transcriptional regulator
SESEC_RS06485	COG1175	transmembrane transport
SESEC_RS06490	COG3833	ABC-type maltose transport systems, permease component
SESEC_RS06500	COG3833	ABC-type maltose transport systems, permease component
SESEC_RS06505	COG1175	transmembrane transport
SESEC_RS06515	COG0366	Alpha amylase catalytic
SESEC_RS06520	COG2182	Extracellular solute-binding protein
SESEC_RS06525	COG0657	acetylesterase activity
SESEC_RS06530	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SESEC_RS06540	COG1696	Membrane protein involved in D-alanine export
SESEC_RS06555	COG0556	nucleotide-excision repair
SESEC_RS06565	COG1126	abc transporter atp-binding protein
SESEC_RS06570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SESEC_RS06580	COG1447	Phosphotransferase system cellobiose-specific component IIA
SESEC_RS06590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SESEC_RS06590	COG3711	transcriptional antiterminator
SESEC_RS06600	COG2723	6-phospho-beta-galactosidase activity
SESEC_RS06615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SESEC_RS06620	COG2309	aminopeptidase activity
SESEC_RS06625	COG1187	pseudouridine synthase activity
SESEC_RS06635	COG2814	Major facilitator Superfamily
SESEC_RS06655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SESEC_RS06670	COG0800	Aldolase
SESEC_RS06685	COG1028	Short-chain dehydrogenase reductase Sdr
SESEC_RS06700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SESEC_RS06705	COG3715	PTS system
SESEC_RS06710	COG3716	PTS system mannose fructose sorbose family IID component
SESEC_RS06715	COG1609	Transcriptional regulator
SESEC_RS06750	COG1078	dGTPase activity
SESEC_RS06790	COG1191	sigma factor activity
SESEC_RS06835	COG2801	Transposase and inactivated derivatives
SESEC_RS06865	COG4443	Transcriptional Coactivator p15 (PC4)
SESEC_RS06875	COG0826	peptidase U32
SESEC_RS06900	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SESEC_RS06920	COG2183	response to ionizing radiation
SESEC_RS06930	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SESEC_RS06940	COG0573	inorganic phosphate transmembrane transporter activity
SESEC_RS06945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SESEC_RS06950	COG5002	protein histidine kinase activity
SESEC_RS06955	COG0745	RESPONSE REGULATOR receiver
SESEC_RS06965	COG0701	Predicted permease
SESEC_RS06970	COG3689	TIGRFAM TIGR03943 family protein
SESEC_RS06980	COG2190	(PTS) system
SESEC_RS06980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SESEC_RS06980	COG1263	PTS System
SESEC_RS06985	COG3711	transcriptional antiterminator
SESEC_RS06990	COG0552	protein localization to endoplasmic reticulum
SESEC_RS06995	COG0561	phosphatase activity
SESEC_RS07000	COG0561	phosphatase activity
SESEC_RS07010	COG1136	(ABC) transporter
SESEC_RS07055	COG1196	nuclear chromosome segregation
SESEC_RS07060	COG0571	ribonuclease III activity
SESEC_RS07075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SESEC_RS07080	COG5002	protein histidine kinase activity
SESEC_RS07085	COG0745	RESPONSE REGULATOR receiver
SESEC_RS07120	COG4555	ABC transporter
SESEC_RS07135	COG1131	(ABC) transporter
SESEC_RS07160	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SESEC_RS07165	COG0438	transferase activity, transferring glycosyl groups
SESEC_RS07180	COG1609	Transcriptional regulator
SESEC_RS07185	COG0006	proline dipeptidase activity
SESEC_RS07195	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SESEC_RS07210	COG0463	Glycosyl transferase, family 2
SESEC_RS07220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SESEC_RS07225	COG0557	exoribonuclease II activity
SESEC_RS07265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SESEC_RS07270	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SESEC_RS07275	COG1447	Phosphotransferase system cellobiose-specific component IIA
SESEC_RS07280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SESEC_RS07290	COG1940	carbohydrate kinase activity
SESEC_RS07325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SESEC_RS07340	COG0542	response to heat
SESEC_RS07345	COG1396	sequence-specific DNA binding
SESEC_RS07375	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
SESEC_RS07395	COG1396	sequence-specific DNA binding
SESEC_RS07555	COG2610	gluconate transmembrane transporter activity
SESEC_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
SESEC_RS07570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SESEC_RS07575	COG0183	Belongs to the thiolase family
SESEC_RS07580	COG0583	DNA-binding transcription factor activity
SESEC_RS07600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SESEC_RS07615	COG1573	uracil-dna glycosylase
SESEC_RS07620	COG1702	phosphate starvation-inducible protein PhoH
SESEC_RS07655	COG0444	Belongs to the ABC transporter superfamily
SESEC_RS07660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SESEC_RS07665	COG0601	transmembrane transport
SESEC_RS07670	COG0747	negative chemotaxis
SESEC_RS07730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SESEC_RS07750	COG0673	inositol 2-dehydrogenase activity
SESEC_RS07760	COG1028	Short-chain dehydrogenase reductase Sdr
SESEC_RS07775	COG2801	Transposase and inactivated derivatives
SESEC_RS07785	COG1376	ErfK ybiS ycfS ynhG family protein
SESEC_RS07800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SESEC_RS07820	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SESEC_RS07820	COG1605	Chorismate mutase
SESEC_RS07825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SESEC_RS07840	COG3250	beta-galactosidase activity
SESEC_RS07845	COG4753	response regulator
SESEC_RS07845	COG2207	Transcriptional regulator
SESEC_RS07850	COG2972	Histidine kinase
SESEC_RS07860	COG1653	transport
SESEC_RS07865	COG0395	ABC-type sugar transport system, permease component
SESEC_RS07870	COG1175	transmembrane transport
SESEC_RS07875	COG1940	carbohydrate kinase activity
SESEC_RS07885	COG2723	6-phospho-beta-galactosidase activity
SESEC_RS07890	COG3291	Pkd domain containing protein
SESEC_RS07890	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SESEC_RS07905	COG0383	alpha-mannosidase activity
SESEC_RS07910	COG1136	(ABC) transporter
SESEC_RS07955	COG2274	protein secretion by the type I secretion system
SESEC_RS07970	COG3290	protein histidine kinase activity
SESEC_RS08080	COG1040	competence protein
SESEC_RS08085	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SESEC_RS08090	COG1739	Uncharacterized protein family UPF0029
SESEC_RS08100	COG1098	S1 RNA binding domain
SESEC_RS08110	COG2197	response regulator
SESEC_RS08115	COG4585	Histidine kinase
SESEC_RS08140	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SESEC_RS08140	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SESEC_RS08145	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SESEC_RS08150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SESEC_RS08170	COG1854	S-ribosylhomocysteine lyase activity
SESEC_RS08180	COG0116	Belongs to the methyltransferase superfamily
SESEC_RS08190	COG4474	Belongs to the UPF0398 family
SESEC_RS08200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SESEC_RS08205	COG3579	cysteine-type endopeptidase activity
SESEC_RS08210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SESEC_RS08215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SESEC_RS08220	COG1113	amino acid transport
SESEC_RS08225	COG0492	ferredoxin-NADP+ reductase activity
SESEC_RS08235	COG1126	abc transporter atp-binding protein
SESEC_RS08245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SESEC_RS08255	COG0513	Belongs to the DEAD box helicase family
SESEC_RS08265	COG0768	penicillin binding
SESEC_RS08305	COG1131	(ABC) transporter
SESEC_RS08365	COG1774	PSP1 C-terminal conserved region
SESEC_RS08370	COG0470	DNA polymerase III
SESEC_RS08400	COG2244	polysaccharide biosynthetic process
SESEC_RS08410	COG1120	ATPase activity
SESEC_RS08415	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SESEC_RS08420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SESEC_RS08425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SESEC_RS08435	COG1227	inorganic diphosphatase activity
SESEC_RS08440	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SESEC_RS08445	COG1253	flavin adenine dinucleotide binding
SESEC_RS08450	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SESEC_RS08460	COG1242	4 iron, 4 sulfur cluster binding
SESEC_RS08465	COG0671	phosphoesterase, PA-phosphatase related
SESEC_RS08470	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SESEC_RS08525	COG1187	pseudouridine synthase activity
SESEC_RS08540	COG0582	viral genome integration into host DNA
SESEC_RS08585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SESEC_RS08590	COG5433	transposase activity
SESEC_RS08595	COG1254	Belongs to the acylphosphatase family
SESEC_RS08610	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SESEC_RS08640	COG1484	DNA-dependent DNA replication
SESEC_RS08655	COG5002	protein histidine kinase activity
SESEC_RS08660	COG0745	RESPONSE REGULATOR receiver
SESEC_RS08675	COG1704	LemA family
SESEC_RS08685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SESEC_RS08690	COG0569	domain protein
SESEC_RS08695	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SESEC_RS08700	COG1114	Component of the transport system for branched-chain amino acids
SESEC_RS08715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SESEC_RS08720	COG1464	Belongs to the NlpA lipoprotein family
SESEC_RS08725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SESEC_RS08735	COG0789	Transcriptional regulator
SESEC_RS08745	COG2226	methyltransferase
SESEC_RS08750	COG0799	negative regulation of ribosome biogenesis
SESEC_RS08755	COG1713	HD superfamily hydrolase involved in NAD metabolism
SESEC_RS08760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SESEC_RS08765	COG1534	Rna-binding protein
SESEC_RS08770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SESEC_RS08775	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SESEC_RS08825	COG0444	Belongs to the ABC transporter superfamily
SESEC_RS08830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SESEC_RS08835	COG0601	transmembrane transport
SESEC_RS08840	COG4166	transmembrane transport
SESEC_RS08845	COG1686	Belongs to the peptidase S11 family
SESEC_RS08850	COG1686	Belongs to the peptidase S11 family
SESEC_RS08860	COG0719	Fe-S assembly protein
SESEC_RS08870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SESEC_RS08875	COG0719	Fe-S assembly protein
SESEC_RS08885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SESEC_RS08900	COG0765	amino acid transport
SESEC_RS08905	COG1126	abc transporter atp-binding protein
SESEC_RS08945	COG3843	relaxase mobilization nuclease domain protein
SESEC_RS08995	COG3942	CHAP domain
SESEC_RS08995	COG1388	LysM domain
SESEC_RS09085	COG0191	fructose-bisphosphate aldolase activity
SESEC_RS09100	COG0504	CTP synthase activity
SESEC_RS09115	COG0366	Alpha amylase catalytic
SESEC_RS09120	COG0668	transmembrane transport
SESEC_RS09135	COG0352	thiamine-phosphate diphosphorylase activity
SESEC_RS09135	COG0351	phosphomethylpyrimidine kinase
SESEC_RS09145	COG0527	aspartate kinase activity
SESEC_RS09195	COG0803	Belongs to the bacterial solute-binding protein 9 family
SESEC_RS09205	COG1597	lipid kinase activity
SESEC_RS09210	COG1609	Transcriptional regulator
SESEC_RS09215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SESEC_RS09220	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SESEC_RS09225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SESEC_RS09230	COG2017	converts alpha-aldose to the beta-anomer
SESEC_RS09240	COG4916	TIR domain
SESEC_RS09300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SESEC_RS09305	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SESEC_RS09330	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SESEC_RS09340	COG1045	serine acetyltransferase
SESEC_RS09350	COG1185	polyribonucleotide nucleotidyltransferase activity
SESEC_RS09355	COG2801	Transposase and inactivated derivatives
SESEC_RS09380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SESEC_RS09385	COG1846	Transcriptional regulator
SESEC_RS09400	COG0442	prolyl-tRNA aminoacylation
SESEC_RS09410	COG4589	Belongs to the CDS family
SESEC_RS09420	COG1862	Preprotein translocase
SESEC_RS09435	COG3842	ATPase activity
SESEC_RS09480	COG1263	PTS System
SESEC_RS09480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SESEC_RS09480	COG2190	(PTS) system
SESEC_RS09485	COG1609	Transcriptional regulator
SESEC_RS09500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SESEC_RS09505	COG2264	protein methyltransferase activity
SESEC_RS09535	COG0512	Glutamine amidotransferase of anthranilate synthase
SESEC_RS09540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SESEC_RS09570	COG1132	(ABC) transporter
SESEC_RS09615	COG1882	Formate acetyltransferase
SESEC_RS09620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SESEC_RS09625	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SESEC_RS09630	COG1447	Phosphotransferase system cellobiose-specific component IIA
SESEC_RS09635	COG2390	Transcriptional regulator
SESEC_RS09640	COG1349	DNA-binding transcription factor activity
SESEC_RS09695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SESEC_RS09700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SESEC_RS09705	COG1428	Deoxynucleoside kinase
SESEC_RS09720	COG4120	Belongs to the binding-protein-dependent transport system permease family
SESEC_RS09750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SESEC_RS09755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SESEC_RS09765	COG1363	Peptidase, m42
SESEC_RS09770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SESEC_RS09800	COG0602	queuosine metabolic process
SESEC_RS09815	COG1328	CTP reductase activity
SESEC_RS09840	COG1393	Belongs to the ArsC family
SESEC_RS09870	COG0519	Catalyzes the synthesis of GMP from XMP
SESEC_RS09875	COG0632	four-way junction helicase activity
SESEC_RS09880	COG2814	Major facilitator Superfamily
SESEC_RS09900	COG1438	arginine binding
SESEC_RS09905	COG0018	arginyl-trna synthetase
SESEC_RS09910	COG0488	(ABC) transporter
SESEC_RS09915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SESEC_RS09920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SESEC_RS09925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SESEC_RS09930	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SESEC_RS09935	COG0124	histidyl-tRNA synthetase
SESEC_RS09970	COG2197	response regulator
SESEC_RS09985	COG0577	efflux transmembrane transporter activity
SESEC_RS09985	COG1136	(ABC) transporter
SESEC_RS10015	COG2801	Transposase and inactivated derivatives
SESEC_RS10035	COG1511	domain protein
SESEC_RS10055	COG0305	Participates in initiation and elongation during chromosome replication
SESEC_RS10075	COG2816	NAD+ diphosphatase activity
SESEC_RS10085	COG1760	l-serine dehydratase
SESEC_RS10090	COG1760	l-serine dehydratase
SESEC_RS10100	COG0741	lytic transglycosylase activity
SESEC_RS10120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SESEC_RS10130	COG0612	Peptidase, M16
SESEC_RS10140	COG2501	S4 domain
SESEC_RS10170	COG0517	IMP dehydrogenase activity
SESEC_RS10170	COG0516	GMP reductase activity
SESEC_RS10180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SESEC_RS10185	COG0488	(ABC) transporter
SESEC_RS10215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SESEC_RS10220	COG1475	DNA binding
SESEC_RS10275	COG1396	sequence-specific DNA binding