locus-tag	class	description
I2432_RS00010	COG0592	DNA-directed DNA polymerase activity
I2432_RS00025	COG0012	GTP binding
I2432_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I2432_RS00040	COG2244	polysaccharide biosynthetic process
I2432_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I2432_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2432_RS00075	COG0531	amino acid
I2432_RS00195	COG3942	CHAP domain
I2432_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2432_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I2432_RS00260	COG0151	Belongs to the GarS family
I2432_RS00265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I2432_RS00280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2432_RS00295	COG2255	four-way junction helicase activity
I2432_RS00300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I2432_RS00315	COG1454	alcohol dehydrogenase
I2432_RS00315	COG1012	belongs to the aldehyde dehydrogenase family
I2432_RS00320	COG1063	alcohol dehydrogenase
I2432_RS00325	COG1064	alcohol dehydrogenase
I2432_RS00330	COG1132	(ABC) transporter
I2432_RS00340	COG1396	sequence-specific DNA binding
I2432_RS00350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I2432_RS00365	COG0051	transcription antitermination factor activity, RNA binding
I2432_RS00375	COG0088	Forms part of the polypeptide exit tunnel
I2432_RS00380	COG0089	rRNA binding
I2432_RS00470	COG0201	protein transport
I2432_RS00610	COG0582	viral genome integration into host DNA
I2432_RS00620	COG2946	Replication initiation factor
I2432_RS00675	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I2432_RS00690	COG1121	(ABC) transporter
I2432_RS00695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2432_RS00705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2432_RS00705	COG4499	WXG100 protein secretion system (Wss), protein YukC
I2432_RS00710	COG0085	RNA polymerase activity
I2432_RS00715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I2432_RS00745	COG1136	(ABC) transporter
I2432_RS00750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I2432_RS00755	COG1459	type II secretion system
I2432_RS00805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2432_RS00820	COG3959	Transketolase, thiamine diphosphate binding domain
I2432_RS00825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I2432_RS00830	COG3590	peptidase
I2432_RS00835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I2432_RS00850	COG0450	alkyl hydroperoxide reductase
I2432_RS00865	COG4463	regulation of RNA biosynthetic process
I2432_RS00910	COG1051	belongs to the nudix hydrolase family
I2432_RS00915	COG1396	sequence-specific DNA binding
I2432_RS00935	COG1116	anion transmembrane transporter activity
I2432_RS00955	COG0564	pseudouridine synthase activity
I2432_RS00975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2432_RS01010	COG0495	leucyl-tRNA aminoacylation
I2432_RS01020	COG3037	sugar-specific permease SgaT UlaA
I2432_RS01040	COG3623	hexulose-6-phosphate isomerase
I2432_RS01065	COG3448	diguanylate cyclase activity
I2432_RS01065	COG4175	Glycine betaine
I2432_RS01075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2432_RS01075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2432_RS01080	COG1832	CoA-binding protein
I2432_RS01105	COG0343	queuine tRNA-ribosyltransferase activity
I2432_RS01130	COG1268	BioY protein
I2432_RS01135	COG1234	tRNA 3'-trailer cleavage
I2432_RS01160	COG1215	transferase activity, transferring glycosyl groups
I2432_RS01190	COG3711	transcriptional antiterminator
I2432_RS01190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2432_RS01200	COG3730	PTS system glucitol sorbitol-specific
I2432_RS01205	COG3732	PTS system glucitol sorbitol-specific
I2432_RS01235	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I2432_RS01240	COG0457	Tetratricopeptide repeat
I2432_RS01240	COG0705	Rhomboid family
I2432_RS01260	COG1132	(ABC) transporter
I2432_RS01265	COG1132	(ABC) transporter
I2432_RS01275	COG0756	dUTP diphosphatase activity
I2432_RS01325	COG1131	(ABC) transporter
I2432_RS01360	COG1847	R3H domain protein
I2432_RS01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2432_RS01415	COG2190	(PTS) system
I2432_RS01415	COG1263	PTS System
I2432_RS01420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2432_RS01420	COG2190	(PTS) system
I2432_RS01420	COG1263	PTS System
I2432_RS01520	COG0542	response to heat
I2432_RS01650	COG1175	transmembrane transport
I2432_RS01655	COG0395	ABC-type sugar transport system, permease component
I2432_RS01660	COG2731	YhcH YjgK YiaL family protein
I2432_RS01670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2432_RS01680	COG3458	cephalosporin-C deacetylase activity
I2432_RS01685	COG1737	Transcriptional regulator
I2432_RS01690	COG0084	hydrolase, TatD family'
I2432_RS01725	COG1564	THIamine pyrophosphokinase
I2432_RS01740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2432_RS01770	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I2432_RS01785	COG0789	Transcriptional regulator
I2432_RS01790	COG0174	glutamine synthetase
I2432_RS01795	COG4166	transmembrane transport
I2432_RS01800	COG0601	transmembrane transport
I2432_RS01805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2432_RS01810	COG0444	Belongs to the ABC transporter superfamily
I2432_RS01815	COG4608	Belongs to the ABC transporter superfamily
I2432_RS01830	COG1214	PFAM Peptidase M22, glycoprotease
I2432_RS01845	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I2432_RS01855	COG2081	HI0933 family
I2432_RS01875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I2432_RS01890	COG5002	protein histidine kinase activity
I2432_RS01925	COG2936	dipeptidyl-peptidase activity
I2432_RS01930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2432_RS01935	COG2814	Major facilitator Superfamily
I2432_RS01945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2432_RS01955	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2432_RS01965	COG1882	Formate acetyltransferase
I2432_RS01985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I2432_RS01990	COG0681	Belongs to the peptidase S26 family
I2432_RS02005	COG1286	toxin biosynthetic process
I2432_RS02015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2432_RS02020	COG3118	belongs to the thioredoxin family
I2432_RS02035	COG1194	a g-specific adenine glycosylase
I2432_RS02070	COG0006	proline dipeptidase activity
I2432_RS02075	COG2131	deaminase
I2432_RS02115	COG1609	Transcriptional regulator
I2432_RS02120	COG1621	beta-fructofuranosidase activity
I2432_RS02125	COG2190	(PTS) system
I2432_RS02125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2432_RS02125	COG1263	PTS System
I2432_RS02135	COG1940	carbohydrate kinase activity
I2432_RS02140	COG1482	cell wall glycoprotein biosynthetic process
I2432_RS02145	COG0653	protein targeting
I2432_RS02155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I2432_RS02160	COG3942	CHAP domain
I2432_RS02160	COG1388	LysM domain
I2432_RS02185	COG1120	ATPase activity
I2432_RS02190	COG4988	ABC transporter
I2432_RS02195	COG1132	(ABC) transporter
I2432_RS02210	COG1129	ABC transporter
I2432_RS02215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I2432_RS02220	COG0252	asparaginase activity
I2432_RS02225	COG0561	phosphatase activity
I2432_RS02235	COG0436	Aminotransferase
I2432_RS02240	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I2432_RS02245	COG1335	isochorismatase
I2432_RS02260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I2432_RS02265	COG0697	spore germination
I2432_RS02270	COG2261	transglycosylase associated protein
I2432_RS02280	COG3830	Belongs to the UPF0237 family
I2432_RS02285	COG2848	UPF0210 protein
I2432_RS02290	COG0588	phosphoglycerate mutase activity
I2432_RS02295	COG1876	peptidase activity
I2432_RS02305	COG1420	regulation of RNA biosynthetic process
I2432_RS02320	COG0484	heat shock protein binding
I2432_RS02325	COG1024	Enoyl-CoA hydratase
I2432_RS02335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I2432_RS02345	COG2070	2-Nitropropane dioxygenase
I2432_RS02350	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I2432_RS02355	COG1028	Short-chain dehydrogenase reductase Sdr
I2432_RS02360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2432_RS02375	COG0439	Biotin carboxylase
I2432_RS02380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I2432_RS02405	COG3716	PTS system mannose fructose sorbose family IID component
I2432_RS02410	COG3715	PTS system
I2432_RS02420	COG0561	phosphatase activity
I2432_RS02425	COG2252	PERMEase
I2432_RS02430	COG0802	atpase or kinase
I2432_RS02440	COG1316	TRANSCRIPTIONal
I2432_RS02450	COG0537	adenosine 5'-monophosphoramidase activity
I2432_RS02460	COG1131	(ABC) transporter
I2432_RS02465	COG4473	ABC transporter
I2432_RS02490	COG0195	Participates in both transcription termination and antitermination
I2432_RS02495	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I2432_RS02505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I2432_RS02525	COG2217	Heavy metal translocating P-type atpase
I2432_RS02565	COG3711	transcriptional antiterminator
I2432_RS02570	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2432_RS02575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2432_RS02575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2432_RS02580	COG2723	6-phospho-beta-galactosidase activity
I2432_RS02590	COG2860	membrane
I2432_RS02595	COG0561	phosphatase activity
I2432_RS02610	COG1609	Transcriptional regulator
I2432_RS02615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2432_RS02620	COG1869	D-ribose catabolic process
I2432_RS02630	COG1172	Belongs to the binding-protein-dependent transport system permease family
I2432_RS02635	COG1879	ABC-type sugar transport system periplasmic component
I2432_RS02650	COG1283	sodium-dependent phosphate transmembrane transporter activity
I2432_RS02660	COG0656	L-ascorbic acid biosynthetic process
I2432_RS02670	COG1755	Isoprenylcysteine carboxyl methyltransferase
I2432_RS02680	COG0751	glycine-tRNA ligase activity
I2432_RS02720	COG1131	(ABC) transporter
I2432_RS02760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I2432_RS02765	COG1393	Belongs to the ArsC family
I2432_RS02770	COG0708	Exodeoxyribonuclease III
I2432_RS02825	COG2274	protein secretion by the type I secretion system
I2432_RS02830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2432_RS02855	COG1114	Component of the transport system for branched-chain amino acids
I2432_RS02970	COG0785	Cytochrome C biogenesis protein
I2432_RS02975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2432_RS02985	COG2207	Transcriptional regulator
I2432_RS02985	COG4753	response regulator
I2432_RS02990	COG2972	Histidine kinase
I2432_RS02995	COG2315	Protein conserved in bacteria
I2432_RS03025	COG0454	-acetyltransferase
I2432_RS03035	COG1288	antiporter activity
I2432_RS03040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2432_RS03045	COG0549	Belongs to the carbamate kinase family
I2432_RS03055	COG0742	ribosomal rna small subunit methyltransferase
I2432_RS03060	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I2432_RS03065	COG3480	Lon protease (S16) C-terminal proteolytic domain
I2432_RS03075	COG4470	Protein conserved in bacteria
I2432_RS03090	COG0783	Belongs to the Dps family
I2432_RS03095	COG4483	Protein conserved in bacteria
I2432_RS03100	COG1940	carbohydrate kinase activity
I2432_RS03105	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I2432_RS03110	COG1217	gtp-binding protein TYPA
I2432_RS03135	COG0849	cell division
I2432_RS03145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I2432_RS03165	COG3599	regulation of cell shape
I2432_RS03180	COG0494	nUDIX hydrolase
I2432_RS03185	COG0542	response to heat
I2432_RS03190	COG4703	Protein of unknown function (DUF1797)
I2432_RS03200	COG0765	amino acid transport
I2432_RS03205	COG1126	abc transporter atp-binding protein
I2432_RS03210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2432_RS03220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I2432_RS03240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I2432_RS03245	COG1438	arginine binding
I2432_RS03250	COG0497	DNA recombination
I2432_RS03265	COG2755	lipolytic protein G-D-S-L family
I2432_RS03270	COG4698	Protein conserved in bacteria
I2432_RS03300	COG0167	dihydroorotate dehydrogenase activity
I2432_RS03310	COG1827	regulation of RNA biosynthetic process
I2432_RS03320	COG5433	transposase activity
I2432_RS03325	COG2116	formate transmembrane transporter activity
I2432_RS03330	COG0768	penicillin binding
I2432_RS03345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2432_RS03365	COG0513	Belongs to the DEAD box helicase family
I2432_RS03370	COG3158	transport of potassium into the cell
I2432_RS03380	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I2432_RS03385	COG0204	Acyl-transferase
I2432_RS03395	COG2333	competence protein COMEC
I2432_RS03395	COG0658	competence protein
I2432_RS03420	COG0363	glucosamine-6-phosphate deaminase activity
I2432_RS03425	COG1187	pseudouridine synthase activity
I2432_RS03450	COG0546	phosphoglycolate phosphatase activity
I2432_RS03455	COG4122	O-methyltransferase activity
I2432_RS03475	COG0726	polysaccharide deacetylase
I2432_RS03480	COG0513	Belongs to the DEAD box helicase family
I2432_RS03500	COG1956	GAF domain-containing protein
I2432_RS03505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I2432_RS03515	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I2432_RS03515	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I2432_RS03540	COG2211	Major facilitator Superfamily
I2432_RS03550	COG3250	beta-galactosidase activity
I2432_RS03555	COG2186	Transcriptional regulator
I2432_RS03560	COG0800	Aldolase
I2432_RS03575	COG1028	Short-chain dehydrogenase reductase Sdr
I2432_RS03595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2432_RS03600	COG4109	DRTGG domain
I2432_RS03605	COG0024	Methionine aminopeptidase
I2432_RS03615	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I2432_RS03625	COG1316	TRANSCRIPTIONal
I2432_RS03630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I2432_RS03715	COG0551	DNA topoisomerase type I activity
I2432_RS03715	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2432_RS03745	COG2274	protein secretion by the type I secretion system
I2432_RS03755	COG3290	protein histidine kinase activity
I2432_RS03795	COG2378	regulation of single-species biofilm formation
I2432_RS03840	COG1373	ATPase (AAA superfamily
I2432_RS03850	COG0588	phosphoglycerate mutase activity
I2432_RS03860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I2432_RS03865	COG3859	Proton-coupled thiamine transporter YuaJ
I2432_RS03885	COG0386	Belongs to the glutathione peroxidase family
I2432_RS03890	COG1164	Oligoendopeptidase f
I2432_RS03900	COG0772	Belongs to the SEDS family
I2432_RS03905	COG1396	sequence-specific DNA binding
I2432_RS03930	COG1131	(ABC) transporter
I2432_RS03945	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I2432_RS03960	COG2884	Cell division ATP-binding protein ftsE
I2432_RS03965	COG2177	Part of the ABC transporter FtsEX involved in
I2432_RS03975	COG1199	ATP-dependent helicase activity
I2432_RS03975	COG1199	ATP-dependent helicase activity
I2432_RS03975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2432_RS03975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2432_RS03985	COG0436	Aminotransferase
I2432_RS03990	COG0017	Asparaginyl-tRNA synthetase
I2432_RS04025	COG2188	Transcriptional regulator
I2432_RS04030	COG2222	sugar isomerase
I2432_RS04035	COG3684	Belongs to the aldolase LacD family
I2432_RS04040	COG2188	Transcriptional regulator
I2432_RS04050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2432_RS04050	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2432_RS04055	COG3715	PTS system
I2432_RS04060	COG3716	PTS system mannose fructose sorbose family IID component
I2432_RS04075	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I2432_RS04080	COG2153	protein acetylation
I2432_RS04085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I2432_RS04090	COG0716	FMN binding
I2432_RS04100	COG0038	chloride channel
I2432_RS04125	COG1476	TRANSCRIPTIONal
I2432_RS04145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2432_RS04150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I2432_RS04155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2432_RS04165	COG1012	belongs to the aldehyde dehydrogenase family
I2432_RS04170	COG0772	Belongs to the SEDS family
I2432_RS04230	COG4708	membrane
I2432_RS04240	COG1597	lipid kinase activity
I2432_RS04245	COG1523	belongs to the glycosyl hydrolase 13 family
I2432_RS04250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I2432_RS04255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2432_RS04260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2432_RS04270	COG0058	SHG alpha-glucan phosphorylase activity
I2432_RS04355	COG0577	efflux transmembrane transporter activity
I2432_RS04360	COG1136	(ABC) transporter
I2432_RS04370	COG1309	transcriptional regulator
I2432_RS04400	COG1523	belongs to the glycosyl hydrolase 13 family
I2432_RS04405	COG1595	DNA-templated transcription, initiation
I2432_RS04440	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I2432_RS04445	COG1074	ATP-dependent DNA helicase activity
I2432_RS04455	COG0436	Aminotransferase
I2432_RS04460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2432_RS04470	COG1970	mechanosensitive ion channel activity
I2432_RS04475	COG0358	DNA primase activity
I2432_RS04480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I2432_RS04485	COG2151	metal-sulfur cluster biosynthetic enzyme
I2432_RS04490	COG1091	dTDP-4-dehydrorhamnose reductase activity
I2432_RS04500	COG1215	transferase activity, transferring glycosyl groups
I2432_RS04525	COG0463	Glycosyl transferase, family 2
I2432_RS04545	COG0297	glycogen (starch) synthase activity
I2432_RS04550	COG1368	sulfuric ester hydrolase activity
I2432_RS04555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2432_RS04605	COG1368	sulfuric ester hydrolase activity
I2432_RS04610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I2432_RS04615	COG0710	3-dehydroquinate dehydratase activity
I2432_RS04620	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I2432_RS04625	COG3679	Belongs to the UPF0342 family
I2432_RS04630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2432_RS04640	COG1104	cysteine desulfurase activity
I2432_RS04645	COG0301	tRNA thio-modification
I2432_RS04725	COG3723	Recombinational DNA repair protein, rece pathway
I2432_RS04785	COG1783	phage Terminase large subunit
I2432_RS04910	COG3177	Filamentation induced by cAMP protein fic
I2432_RS04940	COG1131	(ABC) transporter
I2432_RS04945	COG1725	Transcriptional regulator
I2432_RS04960	COG0469	pyruvate kinase activity
I2432_RS04975	COG2824	Alkylphosphonate utilization operon protein PhnA
I2432_RS04980	COG0765	amino acid transport
I2432_RS04985	COG1126	abc transporter atp-binding protein
I2432_RS04990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2432_RS04995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I2432_RS05000	COG1115	amino acid carrier protein
I2432_RS05060	COG4591	ABC-type transport system involved in lipoprotein release permease component
I2432_RS05060	COG1136	(ABC) transporter
I2432_RS05090	COG0196	riboflavin kinase activity
I2432_RS05105	COG0483	inositol monophosphate 1-phosphatase activity
I2432_RS05110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2432_RS05110	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I2432_RS05120	COG0573	inorganic phosphate transmembrane transporter activity
I2432_RS05125	COG0581	inorganic phosphate transmembrane transporter activity
I2432_RS05140	COG0704	Plays a role in the regulation of phosphate uptake
I2432_RS05150	COG0745	RESPONSE REGULATOR receiver
I2432_RS05155	COG5002	protein histidine kinase activity
I2432_RS05200	COG1072	(Pantothenic acid kinase))
I2432_RS05205	COG2813	Specifically methylates the guanine in position
I2432_RS05210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I2432_RS05225	COG1744	ABC transporter substrate-binding protein PnrA-like
I2432_RS05230	COG3845	ABC transporter
I2432_RS05235	COG4603	Belongs to the binding-protein-dependent transport system permease family
I2432_RS05240	COG1079	Belongs to the binding-protein-dependent transport system permease family
I2432_RS05245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2432_RS05250	COG4684	Psort location CytoplasmicMembrane, score
I2432_RS05255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I2432_RS05275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I2432_RS05280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I2432_RS05285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I2432_RS05285	COG1328	CTP reductase activity
I2432_RS05290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2432_RS05305	COG0488	(ABC) transporter
I2432_RS05315	COG1597	lipid kinase activity
I2432_RS05320	COG1272	protein, Hemolysin III
I2432_RS05330	COG2226	methyltransferase
I2432_RS05340	COG1136	(ABC) transporter
I2432_RS05345	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2432_RS05355	COG0758	DNA mediated transformation
I2432_RS05365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2432_RS05385	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I2432_RS05405	COG2851	Citrate transporter
I2432_RS05415	COG0511	ligase activity, forming carbon-carbon bonds
I2432_RS05420	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I2432_RS05455	COG1136	(ABC) transporter
I2432_RS05460	COG0577	efflux transmembrane transporter activity
I2432_RS05465	COG0745	RESPONSE REGULATOR receiver
I2432_RS05475	COG4974	Belongs to the 'phage' integrase family
I2432_RS05485	COG1396	sequence-specific DNA binding
I2432_RS05495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I2432_RS05495	COG0519	Catalyzes the synthesis of GMP from XMP
I2432_RS05500	COG2188	Transcriptional regulator
I2432_RS05510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I2432_RS05530	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2432_RS05535	COG0346	lactoylglutathione lyase activity
I2432_RS05540	COG3764	Sortase (surface protein transpeptidase)
I2432_RS05575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I2432_RS05580	COG1247	-acetyltransferase
I2432_RS05585	COG0009	L-threonylcarbamoyladenylate synthase
I2432_RS05590	COG2890	protein-(glutamine-N5) methyltransferase activity
I2432_RS05605	COG1942	4-Oxalocrotonate Tautomerase
I2432_RS05615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2432_RS05625	COG1174	glycine betaine transport
I2432_RS05640	COG4221	oxidoreductase activity
I2432_RS05645	COG0280	phosphate acetyltransferase
I2432_RS05650	COG0564	pseudouridine synthase activity
I2432_RS05660	COG2357	RelA SpoT domain protein
I2432_RS05675	COG1104	cysteine desulfurase activity
I2432_RS05690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I2432_RS05700	COG0628	permease
I2432_RS05720	COG1177	transmembrane transport
I2432_RS05725	COG1176	ABC-type spermidine putrescine transport system, permease component I
I2432_RS05740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I2432_RS05755	COG0302	gtp cyclohydrolase
I2432_RS05760	COG0285	dihydrofolate synthase activity
I2432_RS05765	COG0083	homoserine kinase activity
I2432_RS05770	COG0460	homoserine dehydrogenase
I2432_RS05800	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I2432_RS05815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I2432_RS05825	COG3425	synthase
I2432_RS05855	COG1132	(ABC) transporter
I2432_RS05860	COG1132	(ABC) transporter
I2432_RS05865	COG0737	Belongs to the 5'-nucleotidase family
I2432_RS05870	COG0242	peptide deformylase activity
I2432_RS05875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I2432_RS05880	COG1132	(ABC) transporter
I2432_RS05890	COG0488	(ABC) transporter
I2432_RS05910	COG1388	LysM domain
I2432_RS05910	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2432_RS05915	COG0693	protein deglycase activity
I2432_RS05930	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2432_RS05930	COG1388	LysM domain
I2432_RS05935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2432_RS05935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2432_RS05935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2432_RS05940	COG1105	Belongs to the carbohydrate kinase PfkB family
I2432_RS05945	COG1349	DNA-binding transcription factor activity
I2432_RS05970	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I2432_RS05985	COG1837	Belongs to the UPF0109 family
I2432_RS06005	COG0577	efflux transmembrane transporter activity
I2432_RS06010	COG1136	(ABC) transporter
I2432_RS06015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2432_RS06020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I2432_RS06050	COG0564	pseudouridine synthase activity
I2432_RS06060	COG0583	DNA-binding transcription factor activity
I2432_RS06065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I2432_RS06115	COG0539	negative regulation of cytoplasmic translation
I2432_RS06135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I2432_RS06150	COG0187	DNA topoisomerase II activity
I2432_RS06165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I2432_RS06175	COG0765	amino acid transport
I2432_RS06180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2432_RS06195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I2432_RS06200	COG0284	orotidine-5'-phosphate decarboxylase activity
I2432_RS06210	COG0583	DNA-binding transcription factor activity
I2432_RS06230	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I2432_RS06285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2432_RS06305	COG4753	response regulator
I2432_RS06305	COG2207	Transcriptional regulator
I2432_RS06310	COG2972	Histidine kinase
I2432_RS06315	COG3716	PTS system mannose fructose sorbose family IID component
I2432_RS06320	COG3715	PTS system
I2432_RS06340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I2432_RS06400	COG0647	UMP catabolic process
I2432_RS06410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I2432_RS06430	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I2432_RS06435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2432_RS06440	COG3442	glutamine amidotransferase
I2432_RS06445	COG0095	Lipoate-protein ligase
I2432_RS06455	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2432_RS06460	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2432_RS06460	COG0022	dehydrogenase e1 component
I2432_RS06465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I2432_RS06470	COG0488	(ABC) transporter
I2432_RS06485	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I2432_RS06500	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I2432_RS06505	COG0457	Tetratricopeptide repeat
I2432_RS06510	COG0628	permease
I2432_RS06515	COG1051	belongs to the nudix hydrolase family
I2432_RS06520	COG1088	dTDP-glucose 4,6-dehydratase activity
I2432_RS06530	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I2432_RS06535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I2432_RS06545	COG2384	SAM-dependent methyltransferase
I2432_RS06550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I2432_RS06570	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I2432_RS06570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I2432_RS06575	COG0300	oxidoreductase activity
I2432_RS06580	COG1234	tRNA 3'-trailer cleavage
I2432_RS06585	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2432_RS06590	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I2432_RS06595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I2432_RS06610	COG0058	SHG alpha-glucan phosphorylase activity
I2432_RS06615	COG1640	4-alpha-glucanotransferase
I2432_RS06620	COG1609	Transcriptional regulator
I2432_RS06630	COG1175	transmembrane transport
I2432_RS06635	COG3833	ABC-type maltose transport systems, permease component
I2432_RS06645	COG3833	ABC-type maltose transport systems, permease component
I2432_RS06650	COG1175	transmembrane transport
I2432_RS06660	COG0366	Alpha amylase catalytic
I2432_RS06665	COG2182	Extracellular solute-binding protein
I2432_RS06670	COG0657	acetylesterase activity
I2432_RS06675	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I2432_RS06685	COG1696	Membrane protein involved in D-alanine export
I2432_RS06705	COG0765	amino acid transport
I2432_RS06710	COG1126	abc transporter atp-binding protein
I2432_RS06720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2432_RS06730	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2432_RS06740	COG3711	transcriptional antiterminator
I2432_RS06740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2432_RS06750	COG2723	6-phospho-beta-galactosidase activity
I2432_RS06765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I2432_RS06775	COG2309	aminopeptidase activity
I2432_RS06780	COG1187	pseudouridine synthase activity
I2432_RS06790	COG2814	Major facilitator Superfamily
I2432_RS06810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I2432_RS06820	COG5492	domain, Protein
I2432_RS06825	COG0800	Aldolase
I2432_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
I2432_RS06855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2432_RS06860	COG3715	PTS system
I2432_RS06865	COG3716	PTS system mannose fructose sorbose family IID component
I2432_RS06870	COG1609	Transcriptional regulator
I2432_RS06905	COG1078	dGTPase activity
I2432_RS06945	COG1191	sigma factor activity
I2432_RS06995	COG2814	Major facilitator Superfamily
I2432_RS07010	COG4443	Transcriptional Coactivator p15 (PC4)
I2432_RS07020	COG0826	peptidase U32
I2432_RS07065	COG2183	response to ionizing radiation
I2432_RS07075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I2432_RS07085	COG0573	inorganic phosphate transmembrane transporter activity
I2432_RS07090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I2432_RS07095	COG5002	protein histidine kinase activity
I2432_RS07100	COG0745	RESPONSE REGULATOR receiver
I2432_RS07110	COG0701	Predicted permease
I2432_RS07115	COG3689	TIGRFAM TIGR03943 family protein
I2432_RS07125	COG2190	(PTS) system
I2432_RS07125	COG1263	PTS System
I2432_RS07125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2432_RS07130	COG3711	transcriptional antiterminator
I2432_RS07135	COG0552	protein localization to endoplasmic reticulum
I2432_RS07140	COG0561	phosphatase activity
I2432_RS07145	COG0561	phosphatase activity
I2432_RS07155	COG1136	(ABC) transporter
I2432_RS07190	COG1196	nuclear chromosome segregation
I2432_RS07195	COG0571	ribonuclease III activity
I2432_RS07215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I2432_RS07220	COG5002	protein histidine kinase activity
I2432_RS07225	COG0745	RESPONSE REGULATOR receiver
I2432_RS07265	COG4555	ABC transporter
I2432_RS07280	COG1131	(ABC) transporter
I2432_RS07310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I2432_RS07315	COG0438	transferase activity, transferring glycosyl groups
I2432_RS07330	COG1609	Transcriptional regulator
I2432_RS07335	COG0006	proline dipeptidase activity
I2432_RS07340	COG2274	protein secretion by the type I secretion system
I2432_RS07355	COG0463	Glycosyl transferase, family 2
I2432_RS07360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I2432_RS07365	COG0557	exoribonuclease II activity
I2432_RS07375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2432_RS07415	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2432_RS07420	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2432_RS07425	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2432_RS07430	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2432_RS07440	COG1940	carbohydrate kinase activity
I2432_RS07450	COG2610	gluconate transmembrane transporter activity
I2432_RS07455	COG1028	Short-chain dehydrogenase reductase Sdr
I2432_RS07465	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I2432_RS07470	COG0183	Belongs to the thiolase family
I2432_RS07475	COG0583	DNA-binding transcription factor activity
I2432_RS07490	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I2432_RS07505	COG1573	uracil-dna glycosylase
I2432_RS07510	COG1702	phosphate starvation-inducible protein PhoH
I2432_RS07515	COG4479	Belongs to the UPF0346 family
I2432_RS07520	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I2432_RS07545	COG0444	Belongs to the ABC transporter superfamily
I2432_RS07550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2432_RS07555	COG0601	transmembrane transport
I2432_RS07560	COG0747	negative chemotaxis
I2432_RS07625	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I2432_RS07635	COG0494	nUDIX hydrolase
I2432_RS07645	COG0673	inositol 2-dehydrogenase activity
I2432_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
I2432_RS07670	COG1376	ErfK ybiS ycfS ynhG family protein
I2432_RS07685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2432_RS07715	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I2432_RS07715	COG1605	Chorismate mutase
I2432_RS07735	COG3250	beta-galactosidase activity
I2432_RS07740	COG4753	response regulator
I2432_RS07740	COG2207	Transcriptional regulator
I2432_RS07745	COG2972	Histidine kinase
I2432_RS07755	COG1653	transport
I2432_RS07760	COG0395	ABC-type sugar transport system, permease component
I2432_RS07765	COG1175	transmembrane transport
I2432_RS07770	COG1940	carbohydrate kinase activity
I2432_RS07780	COG2723	6-phospho-beta-galactosidase activity
I2432_RS07785	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I2432_RS07785	COG3291	Pkd domain containing protein
I2432_RS07800	COG0383	alpha-mannosidase activity
I2432_RS07805	COG1136	(ABC) transporter
I2432_RS07850	COG2274	protein secretion by the type I secretion system
I2432_RS07865	COG3290	protein histidine kinase activity
I2432_RS07890	COG1486	melibiose metabolic process
I2432_RS07895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2432_RS07895	COG1263	PTS System
I2432_RS08005	COG1040	competence protein
I2432_RS08010	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I2432_RS08015	COG1739	Uncharacterized protein family UPF0029
I2432_RS08025	COG1098	S1 RNA binding domain
I2432_RS08035	COG2197	response regulator
I2432_RS08040	COG4585	Histidine kinase
I2432_RS08050	COG2815	serine threonine protein kinase
I2432_RS08050	COG0515	serine threonine protein kinase
I2432_RS08060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2432_RS08060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2432_RS08065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I2432_RS08070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I2432_RS08090	COG1854	S-ribosylhomocysteine lyase activity
I2432_RS08100	COG0116	Belongs to the methyltransferase superfamily
I2432_RS08125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2432_RS08130	COG3579	cysteine-type endopeptidase activity
I2432_RS08140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I2432_RS08145	COG1113	amino acid transport
I2432_RS08150	COG0492	ferredoxin-NADP+ reductase activity
I2432_RS08160	COG1126	abc transporter atp-binding protein
I2432_RS08180	COG0513	Belongs to the DEAD box helicase family
I2432_RS08190	COG0768	penicillin binding
I2432_RS08230	COG1131	(ABC) transporter
I2432_RS08250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I2432_RS08285	COG1774	PSP1 C-terminal conserved region
I2432_RS08290	COG0470	DNA polymerase III
I2432_RS08295	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I2432_RS08320	COG2244	polysaccharide biosynthetic process
I2432_RS08330	COG1120	ATPase activity
I2432_RS08335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I2432_RS08340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2432_RS08345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2432_RS08360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2432_RS08365	COG1253	flavin adenine dinucleotide binding
I2432_RS08370	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I2432_RS08380	COG1242	4 iron, 4 sulfur cluster binding
I2432_RS08385	COG0671	phosphoesterase, PA-phosphatase related
I2432_RS08390	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I2432_RS08445	COG1187	pseudouridine synthase activity
I2432_RS08460	COG0582	viral genome integration into host DNA
I2432_RS08500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2432_RS08505	COG1254	Belongs to the acylphosphatase family
I2432_RS08520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I2432_RS08530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I2432_RS08550	COG1484	DNA-dependent DNA replication
I2432_RS08570	COG0745	RESPONSE REGULATOR receiver
I2432_RS08585	COG1704	LemA family
I2432_RS08595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I2432_RS08600	COG0569	domain protein
I2432_RS08610	COG1114	Component of the transport system for branched-chain amino acids
I2432_RS08625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2432_RS08630	COG1464	Belongs to the NlpA lipoprotein family
I2432_RS08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2432_RS08645	COG0789	Transcriptional regulator
I2432_RS08655	COG2226	methyltransferase
I2432_RS08660	COG0799	negative regulation of ribosome biogenesis
I2432_RS08665	COG1713	HD superfamily hydrolase involved in NAD metabolism
I2432_RS08670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2432_RS08675	COG1534	Rna-binding protein
I2432_RS08680	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2432_RS08685	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I2432_RS08730	COG0444	Belongs to the ABC transporter superfamily
I2432_RS08735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2432_RS08740	COG0601	transmembrane transport
I2432_RS08745	COG4166	transmembrane transport
I2432_RS08750	COG1686	Belongs to the peptidase S11 family
I2432_RS08755	COG1686	Belongs to the peptidase S11 family
I2432_RS08765	COG0719	Fe-S assembly protein
I2432_RS08775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2432_RS08780	COG0719	Fe-S assembly protein
I2432_RS08790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2432_RS08805	COG0765	amino acid transport
I2432_RS08810	COG1126	abc transporter atp-binding protein
I2432_RS08845	COG0191	fructose-bisphosphate aldolase activity
I2432_RS08860	COG0504	CTP synthase activity
I2432_RS08875	COG0366	Alpha amylase catalytic
I2432_RS08880	COG0668	transmembrane transport
I2432_RS08890	COG4720	Psort location CytoplasmicMembrane, score
I2432_RS08895	COG0351	phosphomethylpyrimidine kinase
I2432_RS08895	COG0352	thiamine-phosphate diphosphorylase activity
I2432_RS08905	COG0527	aspartate kinase activity
I2432_RS09020	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2432_RS09030	COG1597	lipid kinase activity
I2432_RS09035	COG1609	Transcriptional regulator
I2432_RS09040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I2432_RS09045	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2432_RS09050	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2432_RS09055	COG2017	converts alpha-aldose to the beta-anomer
I2432_RS09085	COG0577	efflux transmembrane transporter activity
I2432_RS09090	COG1136	(ABC) transporter
I2432_RS09095	COG2274	protein secretion by the type I secretion system
I2432_RS09155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I2432_RS09170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I2432_RS09210	COG0582	viral genome integration into host DNA
I2432_RS09220	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I2432_RS09235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2432_RS09245	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I2432_RS09255	COG1045	serine acetyltransferase
I2432_RS09285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I2432_RS09290	COG1846	Transcriptional regulator
I2432_RS09305	COG0442	prolyl-tRNA aminoacylation
I2432_RS09315	COG4589	Belongs to the CDS family
I2432_RS09325	COG1862	Preprotein translocase
I2432_RS09340	COG3842	ATPase activity
I2432_RS09390	COG2190	(PTS) system
I2432_RS09390	COG1263	PTS System
I2432_RS09390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2432_RS09395	COG1609	Transcriptional regulator
I2432_RS09400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I2432_RS09430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I2432_RS09435	COG0512	Glutamine amidotransferase of anthranilate synthase
I2432_RS09440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I2432_RS09530	COG1882	Formate acetyltransferase
I2432_RS09535	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2432_RS09540	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2432_RS09545	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2432_RS09555	COG1349	DNA-binding transcription factor activity
I2432_RS09560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2432_RS09630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I2432_RS09635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I2432_RS09640	COG1428	Deoxynucleoside kinase
I2432_RS09660	COG4120	Belongs to the binding-protein-dependent transport system permease family
I2432_RS09680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2432_RS09685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2432_RS09695	COG1363	Peptidase, m42
I2432_RS09700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I2432_RS09725	COG3022	response to hydroperoxide
I2432_RS09730	COG0602	queuosine metabolic process
I2432_RS09750	COG1328	CTP reductase activity
I2432_RS09775	COG1393	Belongs to the ArsC family
I2432_RS09805	COG0519	Catalyzes the synthesis of GMP from XMP
I2432_RS09810	COG0632	four-way junction helicase activity
I2432_RS09815	COG2814	Major facilitator Superfamily
I2432_RS09825	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I2432_RS09835	COG1438	arginine binding
I2432_RS09840	COG0018	arginyl-trna synthetase
I2432_RS09845	COG0488	(ABC) transporter
I2432_RS09850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2432_RS09855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2432_RS09860	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2432_RS09865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I2432_RS09875	COG1131	(ABC) transporter
I2432_RS09895	COG0124	histidyl-tRNA synthetase
I2432_RS09910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2432_RS09935	COG2197	response regulator
I2432_RS09950	COG0577	efflux transmembrane transporter activity
I2432_RS09950	COG1136	(ABC) transporter
I2432_RS09990	COG1511	domain protein
I2432_RS10030	COG0305	Participates in initiation and elongation during chromosome replication
I2432_RS10060	COG1760	l-serine dehydratase
I2432_RS10065	COG1760	l-serine dehydratase
I2432_RS10095	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I2432_RS10105	COG0612	Peptidase, M16
I2432_RS10115	COG2501	S4 domain
I2432_RS10150	COG0517	IMP dehydrogenase activity
I2432_RS10150	COG0516	GMP reductase activity
I2432_RS10160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2432_RS10165	COG0488	(ABC) transporter
I2432_RS10195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I2432_RS10200	COG1475	DNA binding