locus-tag	class	description
I2433_RS00010	COG0592	DNA-directed DNA polymerase activity
I2433_RS00025	COG0012	GTP binding
I2433_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
I2433_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I2433_RS00040	COG2244	polysaccharide biosynthetic process
I2433_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I2433_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2433_RS00075	COG0531	amino acid
I2433_RS00195	COG3942	CHAP domain
I2433_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2433_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I2433_RS00255	COG0151	Belongs to the GarS family
I2433_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I2433_RS00275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2433_RS00290	COG2255	four-way junction helicase activity
I2433_RS00295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I2433_RS00310	COG1012	belongs to the aldehyde dehydrogenase family
I2433_RS00310	COG1454	alcohol dehydrogenase
I2433_RS00315	COG1063	alcohol dehydrogenase
I2433_RS00320	COG1064	alcohol dehydrogenase
I2433_RS00330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I2433_RS00335	COG0534	Mate efflux family protein
I2433_RS00340	COG0051	transcription antitermination factor activity, RNA binding
I2433_RS00350	COG0088	Forms part of the polypeptide exit tunnel
I2433_RS00355	COG0089	rRNA binding
I2433_RS00445	COG0201	protein transport
I2433_RS00450	COG0563	adenylate kinase activity
I2433_RS00605	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I2433_RS00620	COG1121	(ABC) transporter
I2433_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2433_RS00635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2433_RS00635	COG4499	WXG100 protein secretion system (Wss), protein YukC
I2433_RS00645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I2433_RS00675	COG1136	(ABC) transporter
I2433_RS00680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I2433_RS00685	COG1459	type II secretion system
I2433_RS00730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2433_RS00745	COG3959	Transketolase, thiamine diphosphate binding domain
I2433_RS00750	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I2433_RS00755	COG3590	peptidase
I2433_RS00760	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I2433_RS00775	COG0450	alkyl hydroperoxide reductase
I2433_RS00790	COG4463	regulation of RNA biosynthetic process
I2433_RS00840	COG1051	belongs to the nudix hydrolase family
I2433_RS00845	COG1396	sequence-specific DNA binding
I2433_RS00865	COG1116	anion transmembrane transporter activity
I2433_RS00885	COG0564	pseudouridine synthase activity
I2433_RS00905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2433_RS00940	COG0495	leucyl-tRNA aminoacylation
I2433_RS00950	COG3037	sugar-specific permease SgaT UlaA
I2433_RS00970	COG3623	hexulose-6-phosphate isomerase
I2433_RS00995	COG3448	diguanylate cyclase activity
I2433_RS00995	COG4175	Glycine betaine
I2433_RS01005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2433_RS01005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2433_RS01010	COG1832	CoA-binding protein
I2433_RS01035	COG0343	queuine tRNA-ribosyltransferase activity
I2433_RS01060	COG1268	BioY protein
I2433_RS01065	COG1234	tRNA 3'-trailer cleavage
I2433_RS01090	COG1215	transferase activity, transferring glycosyl groups
I2433_RS01120	COG3711	transcriptional antiterminator
I2433_RS01120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2433_RS01130	COG3730	PTS system glucitol sorbitol-specific
I2433_RS01135	COG3732	PTS system glucitol sorbitol-specific
I2433_RS01165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I2433_RS01180	COG1609	Transcriptional regulator
I2433_RS01185	COG2190	(PTS) system
I2433_RS01185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2433_RS01185	COG1263	PTS System
I2433_RS01205	COG1196	nuclear chromosome segregation
I2433_RS01230	COG3842	ATPase activity
I2433_RS01245	COG1862	Preprotein translocase
I2433_RS01255	COG4589	Belongs to the CDS family
I2433_RS01265	COG0442	prolyl-tRNA aminoacylation
I2433_RS01280	COG1846	Transcriptional regulator
I2433_RS01285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I2433_RS01315	COG1045	serine acetyltransferase
I2433_RS01325	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I2433_RS01335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2433_RS01360	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I2433_RS01365	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I2433_RS01395	COG1674	ftsk spoiiie
I2433_RS01455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I2433_RS01470	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I2433_RS01500	COG2017	converts alpha-aldose to the beta-anomer
I2433_RS01505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2433_RS01510	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2433_RS01515	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I2433_RS01520	COG1609	Transcriptional regulator
I2433_RS01525	COG1597	lipid kinase activity
I2433_RS01535	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2433_RS01580	COG0527	aspartate kinase activity
I2433_RS01590	COG0351	phosphomethylpyrimidine kinase
I2433_RS01590	COG0352	thiamine-phosphate diphosphorylase activity
I2433_RS01595	COG4720	Psort location CytoplasmicMembrane, score
I2433_RS01605	COG0668	transmembrane transport
I2433_RS01610	COG0366	Alpha amylase catalytic
I2433_RS01640	COG0191	fructose-bisphosphate aldolase activity
I2433_RS01675	COG1126	abc transporter atp-binding protein
I2433_RS01680	COG0765	amino acid transport
I2433_RS01695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2433_RS01705	COG0719	Fe-S assembly protein
I2433_RS01710	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2433_RS01720	COG0719	Fe-S assembly protein
I2433_RS01730	COG1686	Belongs to the peptidase S11 family
I2433_RS01735	COG1686	Belongs to the peptidase S11 family
I2433_RS01740	COG4166	transmembrane transport
I2433_RS01745	COG0601	transmembrane transport
I2433_RS01750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2433_RS01755	COG0444	Belongs to the ABC transporter superfamily
I2433_RS01865	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I2433_RS01870	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2433_RS01875	COG1534	Rna-binding protein
I2433_RS01880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2433_RS01885	COG1713	HD superfamily hydrolase involved in NAD metabolism
I2433_RS01890	COG0799	negative regulation of ribosome biogenesis
I2433_RS01895	COG2226	methyltransferase
I2433_RS01905	COG0789	Transcriptional regulator
I2433_RS01915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2433_RS01920	COG1464	Belongs to the NlpA lipoprotein family
I2433_RS01925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2433_RS01940	COG1114	Component of the transport system for branched-chain amino acids
I2433_RS01950	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I2433_RS01955	COG0569	domain protein
I2433_RS01960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I2433_RS01970	COG1704	LemA family
I2433_RS01985	COG0745	RESPONSE REGULATOR receiver
I2433_RS01990	COG5002	protein histidine kinase activity
I2433_RS02005	COG1484	DNA-dependent DNA replication
I2433_RS02025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I2433_RS02035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I2433_RS02050	COG1254	Belongs to the acylphosphatase family
I2433_RS02055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2433_RS02110	COG1187	pseudouridine synthase activity
I2433_RS02160	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I2433_RS02165	COG0671	phosphoesterase, PA-phosphatase related
I2433_RS02170	COG1242	4 iron, 4 sulfur cluster binding
I2433_RS02175	COG3231	kanamycin kinase activity
I2433_RS02180	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I2433_RS02185	COG1253	flavin adenine dinucleotide binding
I2433_RS02190	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2433_RS02205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2433_RS02210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2433_RS02215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I2433_RS02220	COG1120	ATPase activity
I2433_RS02230	COG2244	polysaccharide biosynthetic process
I2433_RS02255	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I2433_RS02260	COG0470	DNA polymerase III
I2433_RS02265	COG1774	PSP1 C-terminal conserved region
I2433_RS02320	COG1131	(ABC) transporter
I2433_RS02360	COG0768	penicillin binding
I2433_RS02370	COG0513	Belongs to the DEAD box helicase family
I2433_RS02390	COG1126	abc transporter atp-binding protein
I2433_RS02400	COG0492	ferredoxin-NADP+ reductase activity
I2433_RS02405	COG1113	amino acid transport
I2433_RS02410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I2433_RS02420	COG3579	cysteine-type endopeptidase activity
I2433_RS02425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2433_RS02450	COG0116	Belongs to the methyltransferase superfamily
I2433_RS02460	COG1854	S-ribosylhomocysteine lyase activity
I2433_RS02480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I2433_RS02485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I2433_RS02490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2433_RS02490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2433_RS02500	COG0515	serine threonine protein kinase
I2433_RS02500	COG2815	serine threonine protein kinase
I2433_RS02510	COG4585	Histidine kinase
I2433_RS02515	COG2197	response regulator
I2433_RS02525	COG1098	S1 RNA binding domain
I2433_RS02535	COG1739	Uncharacterized protein family UPF0029
I2433_RS02540	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I2433_RS02545	COG1040	competence protein
I2433_RS02655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2433_RS02655	COG1263	PTS System
I2433_RS02660	COG1486	melibiose metabolic process
I2433_RS02685	COG3290	protein histidine kinase activity
I2433_RS02700	COG2274	protein secretion by the type I secretion system
I2433_RS02745	COG1136	(ABC) transporter
I2433_RS02750	COG0383	alpha-mannosidase activity
I2433_RS02765	COG3291	Pkd domain containing protein
I2433_RS02765	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I2433_RS02770	COG2723	6-phospho-beta-galactosidase activity
I2433_RS02780	COG1940	carbohydrate kinase activity
I2433_RS02785	COG1175	transmembrane transport
I2433_RS02790	COG0395	ABC-type sugar transport system, permease component
I2433_RS02795	COG1653	transport
I2433_RS02805	COG2972	Histidine kinase
I2433_RS02810	COG2207	Transcriptional regulator
I2433_RS02810	COG4753	response regulator
I2433_RS02815	COG3250	beta-galactosidase activity
I2433_RS02830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I2433_RS02835	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I2433_RS02835	COG1605	Chorismate mutase
I2433_RS02860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2433_RS02875	COG1376	ErfK ybiS ycfS ynhG family protein
I2433_RS02890	COG1028	Short-chain dehydrogenase reductase Sdr
I2433_RS02900	COG0673	inositol 2-dehydrogenase activity
I2433_RS02920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I2433_RS02990	COG0747	negative chemotaxis
I2433_RS02995	COG0601	transmembrane transport
I2433_RS03000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2433_RS03005	COG0444	Belongs to the ABC transporter superfamily
I2433_RS03040	COG1702	phosphate starvation-inducible protein PhoH
I2433_RS03045	COG1573	uracil-dna glycosylase
I2433_RS03060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I2433_RS03075	COG1131	(ABC) transporter
I2433_RS03085	COG0583	DNA-binding transcription factor activity
I2433_RS03090	COG0183	Belongs to the thiolase family
I2433_RS03095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I2433_RS03105	COG1028	Short-chain dehydrogenase reductase Sdr
I2433_RS03110	COG2610	gluconate transmembrane transporter activity
I2433_RS03120	COG1940	carbohydrate kinase activity
I2433_RS03135	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2433_RS03140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2433_RS03145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2433_RS03185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2433_RS03195	COG0557	exoribonuclease II activity
I2433_RS03200	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I2433_RS03205	COG0463	Glycosyl transferase, family 2
I2433_RS03215	COG0006	proline dipeptidase activity
I2433_RS03220	COG1609	Transcriptional regulator
I2433_RS03235	COG0438	transferase activity, transferring glycosyl groups
I2433_RS03240	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I2433_RS03275	COG4555	ABC transporter
I2433_RS03290	COG2376	Dihydroxyacetone kinase
I2433_RS03300	COG2376	Dihydroxyacetone kinase
I2433_RS03305	COG1461	Dihydroxyacetone kinase
I2433_RS03310	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I2433_RS03315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2433_RS03340	COG0745	RESPONSE REGULATOR receiver
I2433_RS03345	COG5002	protein histidine kinase activity
I2433_RS03350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I2433_RS03370	COG0571	ribonuclease III activity
I2433_RS03375	COG1196	nuclear chromosome segregation
I2433_RS03410	COG1136	(ABC) transporter
I2433_RS03420	COG0561	phosphatase activity
I2433_RS03425	COG0561	phosphatase activity
I2433_RS03430	COG0552	protein localization to endoplasmic reticulum
I2433_RS03435	COG3711	transcriptional antiterminator
I2433_RS03440	COG1263	PTS System
I2433_RS03440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2433_RS03440	COG2190	(PTS) system
I2433_RS03450	COG3689	TIGRFAM TIGR03943 family protein
I2433_RS03455	COG0701	Predicted permease
I2433_RS03465	COG0745	RESPONSE REGULATOR receiver
I2433_RS03470	COG5002	protein histidine kinase activity
I2433_RS03475	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I2433_RS03480	COG0573	inorganic phosphate transmembrane transporter activity
I2433_RS03490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I2433_RS03500	COG2183	response to ionizing radiation
I2433_RS03545	COG0826	peptidase U32
I2433_RS03555	COG4443	Transcriptional Coactivator p15 (PC4)
I2433_RS03570	COG2814	Major facilitator Superfamily
I2433_RS03585	COG1191	sigma factor activity
I2433_RS03625	COG1078	dGTPase activity
I2433_RS03665	COG1609	Transcriptional regulator
I2433_RS03670	COG3716	PTS system mannose fructose sorbose family IID component
I2433_RS03675	COG3715	PTS system
I2433_RS03680	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2433_RS03695	COG1028	Short-chain dehydrogenase reductase Sdr
I2433_RS03710	COG0800	Aldolase
I2433_RS03715	COG5492	domain, Protein
I2433_RS03725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I2433_RS03750	COG2814	Major facilitator Superfamily
I2433_RS03760	COG1187	pseudouridine synthase activity
I2433_RS03765	COG2309	aminopeptidase activity
I2433_RS03775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I2433_RS03790	COG2723	6-phospho-beta-galactosidase activity
I2433_RS03800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2433_RS03800	COG3711	transcriptional antiterminator
I2433_RS03810	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2433_RS03820	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2433_RS03830	COG1126	abc transporter atp-binding protein
I2433_RS03835	COG0765	amino acid transport
I2433_RS03855	COG1696	Membrane protein involved in D-alanine export
I2433_RS03865	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I2433_RS03870	COG0657	acetylesterase activity
I2433_RS03875	COG2182	Extracellular solute-binding protein
I2433_RS03880	COG0366	Alpha amylase catalytic
I2433_RS03890	COG1175	transmembrane transport
I2433_RS03895	COG3833	ABC-type maltose transport systems, permease component
I2433_RS03905	COG3833	ABC-type maltose transport systems, permease component
I2433_RS03910	COG1175	transmembrane transport
I2433_RS03920	COG1609	Transcriptional regulator
I2433_RS03925	COG1640	4-alpha-glucanotransferase
I2433_RS03930	COG0058	SHG alpha-glucan phosphorylase activity
I2433_RS03945	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I2433_RS03950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I2433_RS03955	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2433_RS03960	COG1234	tRNA 3'-trailer cleavage
I2433_RS03965	COG0300	oxidoreductase activity
I2433_RS03970	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I2433_RS03970	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I2433_RS03990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I2433_RS03995	COG2384	SAM-dependent methyltransferase
I2433_RS04005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I2433_RS04010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I2433_RS04020	COG1088	dTDP-glucose 4,6-dehydratase activity
I2433_RS04025	COG1051	belongs to the nudix hydrolase family
I2433_RS04030	COG0628	permease
I2433_RS04035	COG0457	Tetratricopeptide repeat
I2433_RS04040	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I2433_RS04055	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I2433_RS04075	COG0488	(ABC) transporter
I2433_RS04080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I2433_RS04085	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2433_RS04085	COG0022	dehydrogenase e1 component
I2433_RS04090	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2433_RS04100	COG0095	Lipoate-protein ligase
I2433_RS04105	COG3442	glutamine amidotransferase
I2433_RS04110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2433_RS04115	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I2433_RS04135	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I2433_RS04145	COG0647	UMP catabolic process
I2433_RS04210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I2433_RS04230	COG3715	PTS system
I2433_RS04235	COG3716	PTS system mannose fructose sorbose family IID component
I2433_RS04240	COG2972	Histidine kinase
I2433_RS04245	COG2207	Transcriptional regulator
I2433_RS04245	COG4753	response regulator
I2433_RS04265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2433_RS04315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I2433_RS04335	COG0583	DNA-binding transcription factor activity
I2433_RS04345	COG0284	orotidine-5'-phosphate decarboxylase activity
I2433_RS04350	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I2433_RS04365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2433_RS04370	COG0765	amino acid transport
I2433_RS04380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I2433_RS04395	COG0187	DNA topoisomerase II activity
I2433_RS04410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I2433_RS04430	COG0539	negative regulation of cytoplasmic translation
I2433_RS04485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I2433_RS04490	COG0583	DNA-binding transcription factor activity
I2433_RS04500	COG0564	pseudouridine synthase activity
I2433_RS04530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I2433_RS04535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2433_RS04540	COG1136	(ABC) transporter
I2433_RS04545	COG0577	efflux transmembrane transporter activity
I2433_RS04560	COG1837	Belongs to the UPF0109 family
I2433_RS04575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I2433_RS04605	COG1349	DNA-binding transcription factor activity
I2433_RS04610	COG1105	Belongs to the carbohydrate kinase PfkB family
I2433_RS04615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2433_RS04615	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2433_RS04615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2433_RS04620	COG1388	LysM domain
I2433_RS04620	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2433_RS04635	COG0693	protein deglycase activity
I2433_RS04640	COG1388	LysM domain
I2433_RS04640	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2433_RS04660	COG0488	(ABC) transporter
I2433_RS04670	COG1132	(ABC) transporter
I2433_RS04675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I2433_RS04680	COG0242	peptide deformylase activity
I2433_RS04685	COG0737	Belongs to the 5'-nucleotidase family
I2433_RS04690	COG1132	(ABC) transporter
I2433_RS04695	COG1132	(ABC) transporter
I2433_RS04725	COG3425	synthase
I2433_RS04735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I2433_RS04750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I2433_RS04785	COG0083	homoserine kinase activity
I2433_RS04790	COG0285	dihydrofolate synthase activity
I2433_RS04795	COG0302	gtp cyclohydrolase
I2433_RS04810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I2433_RS04815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I2433_RS04825	COG1176	ABC-type spermidine putrescine transport system, permease component I
I2433_RS04830	COG1177	transmembrane transport
I2433_RS04850	COG0628	permease
I2433_RS04860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I2433_RS04875	COG1104	cysteine desulfurase activity
I2433_RS04890	COG2357	RelA SpoT domain protein
I2433_RS04900	COG0564	pseudouridine synthase activity
I2433_RS04905	COG0280	phosphate acetyltransferase
I2433_RS04910	COG4221	oxidoreductase activity
I2433_RS04925	COG1174	glycine betaine transport
I2433_RS04935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2433_RS04945	COG1942	4-Oxalocrotonate Tautomerase
I2433_RS04960	COG2890	protein-(glutamine-N5) methyltransferase activity
I2433_RS04965	COG0009	L-threonylcarbamoyladenylate synthase
I2433_RS04970	COG1247	-acetyltransferase
I2433_RS04975	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I2433_RS05005	COG3764	Sortase (surface protein transpeptidase)
I2433_RS05010	COG0346	lactoylglutathione lyase activity
I2433_RS05015	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2433_RS05035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I2433_RS05045	COG2188	Transcriptional regulator
I2433_RS05065	COG1396	sequence-specific DNA binding
I2433_RS05075	COG4974	Belongs to the 'phage' integrase family
I2433_RS05080	COG5002	protein histidine kinase activity
I2433_RS05085	COG0745	RESPONSE REGULATOR receiver
I2433_RS05090	COG0577	efflux transmembrane transporter activity
I2433_RS05095	COG1136	(ABC) transporter
I2433_RS05125	COG3052	prosthetic group binding
I2433_RS05130	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I2433_RS05135	COG0511	ligase activity, forming carbon-carbon bonds
I2433_RS05145	COG2851	Citrate transporter
I2433_RS05155	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I2433_RS05165	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I2433_RS05170	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I2433_RS05185	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2433_RS05195	COG0758	DNA mediated transformation
I2433_RS05205	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2433_RS05210	COG1136	(ABC) transporter
I2433_RS05210	COG0577	efflux transmembrane transporter activity
I2433_RS05235	COG1131	(ABC) transporter
I2433_RS05260	COG2226	methyltransferase
I2433_RS05270	COG1272	protein, Hemolysin III
I2433_RS05275	COG1597	lipid kinase activity
I2433_RS05285	COG0488	(ABC) transporter
I2433_RS05300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2433_RS05305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I2433_RS05305	COG1328	CTP reductase activity
I2433_RS05310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I2433_RS05315	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I2433_RS05325	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I2433_RS05335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I2433_RS05340	COG4684	Psort location CytoplasmicMembrane, score
I2433_RS05345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2433_RS05350	COG1079	Belongs to the binding-protein-dependent transport system permease family
I2433_RS05355	COG4603	Belongs to the binding-protein-dependent transport system permease family
I2433_RS05360	COG3845	ABC transporter
I2433_RS05365	COG1744	ABC transporter substrate-binding protein PnrA-like
I2433_RS05380	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I2433_RS05385	COG2813	Specifically methylates the guanine in position
I2433_RS05390	COG1072	(Pantothenic acid kinase))
I2433_RS05450	COG5002	protein histidine kinase activity
I2433_RS05455	COG0745	RESPONSE REGULATOR receiver
I2433_RS05465	COG0704	Plays a role in the regulation of phosphate uptake
I2433_RS05480	COG0581	inorganic phosphate transmembrane transporter activity
I2433_RS05485	COG0573	inorganic phosphate transmembrane transporter activity
I2433_RS05495	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I2433_RS05495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2433_RS05500	COG0483	inositol monophosphate 1-phosphatase activity
I2433_RS05515	COG0196	riboflavin kinase activity
I2433_RS05545	COG1136	(ABC) transporter
I2433_RS05545	COG4591	ABC-type transport system involved in lipoprotein release permease component
I2433_RS05600	COG1115	amino acid carrier protein
I2433_RS05605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I2433_RS05610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2433_RS05615	COG1126	abc transporter atp-binding protein
I2433_RS05620	COG0765	amino acid transport
I2433_RS05625	COG2824	Alkylphosphonate utilization operon protein PhnA
I2433_RS05640	COG0469	pyruvate kinase activity
I2433_RS05655	COG1725	Transcriptional regulator
I2433_RS05660	COG1131	(ABC) transporter
I2433_RS05690	COG1388	LysM domain
I2433_RS05690	COG0860	N-Acetylmuramoyl-L-alanine amidase
I2433_RS05790	COG0740	serine-type endopeptidase activity
I2433_RS05825	COG0582	viral genome integration into host DNA
I2433_RS05900	COG3561	AntA/AntB antirepressor
I2433_RS05955	COG0301	tRNA thio-modification
I2433_RS05960	COG1104	cysteine desulfurase activity
I2433_RS05970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2433_RS05985	COG0710	3-dehydroquinate dehydratase activity
I2433_RS05990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I2433_RS05995	COG1368	sulfuric ester hydrolase activity
I2433_RS06045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2433_RS06050	COG1368	sulfuric ester hydrolase activity
I2433_RS06055	COG0297	glycogen (starch) synthase activity
I2433_RS06075	COG0463	Glycosyl transferase, family 2
I2433_RS06100	COG0463	Glycosyl transferase, family 2
I2433_RS06110	COG1091	dTDP-4-dehydrorhamnose reductase activity
I2433_RS06115	COG2151	metal-sulfur cluster biosynthetic enzyme
I2433_RS06120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I2433_RS06125	COG0358	DNA primase activity
I2433_RS06130	COG1970	mechanosensitive ion channel activity
I2433_RS06140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2433_RS06145	COG0436	Aminotransferase
I2433_RS06190	COG1595	DNA-templated transcription, initiation
I2433_RS06195	COG1523	belongs to the glycosyl hydrolase 13 family
I2433_RS06245	COG1309	transcriptional regulator
I2433_RS06260	COG0577	efflux transmembrane transporter activity
I2433_RS06335	COG0058	SHG alpha-glucan phosphorylase activity
I2433_RS06340	COG0297	glycogen (starch) synthase activity
I2433_RS06345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2433_RS06350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2433_RS06355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I2433_RS06360	COG1523	belongs to the glycosyl hydrolase 13 family
I2433_RS06365	COG1597	lipid kinase activity
I2433_RS06375	COG4708	membrane
I2433_RS06440	COG0772	Belongs to the SEDS family
I2433_RS06445	COG1012	belongs to the aldehyde dehydrogenase family
I2433_RS06455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2433_RS06460	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I2433_RS06465	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2433_RS06485	COG1476	TRANSCRIPTIONal
I2433_RS06505	COG0038	chloride channel
I2433_RS06515	COG0716	FMN binding
I2433_RS06520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I2433_RS06525	COG2153	protein acetylation
I2433_RS06530	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I2433_RS06545	COG3716	PTS system mannose fructose sorbose family IID component
I2433_RS06550	COG3715	PTS system
I2433_RS06555	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2433_RS06555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2433_RS06565	COG2188	Transcriptional regulator
I2433_RS06570	COG3684	Belongs to the aldolase LacD family
I2433_RS06575	COG2222	sugar isomerase
I2433_RS06580	COG2188	Transcriptional regulator
I2433_RS06605	COG1660	Displays ATPase and GTPase activities
I2433_RS06615	COG0017	Asparaginyl-tRNA synthetase
I2433_RS06620	COG0436	Aminotransferase
I2433_RS06630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2433_RS06630	COG1199	ATP-dependent helicase activity
I2433_RS06640	COG2177	Part of the ABC transporter FtsEX involved in
I2433_RS06645	COG2884	Cell division ATP-binding protein ftsE
I2433_RS06665	COG2274	protein secretion by the type I secretion system
I2433_RS06680	COG1131	(ABC) transporter
I2433_RS06690	COG0772	Belongs to the SEDS family
I2433_RS06700	COG1164	Oligoendopeptidase f
I2433_RS06705	COG0386	Belongs to the glutathione peroxidase family
I2433_RS06730	COG3859	Proton-coupled thiamine transporter YuaJ
I2433_RS06735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I2433_RS06745	COG0588	phosphoglycerate mutase activity
I2433_RS06755	COG1373	ATPase (AAA superfamily
I2433_RS06895	COG0640	Transcriptional regulator
I2433_RS06935	COG0740	serine-type endopeptidase activity
I2433_RS06950	COG4626	Terminase
I2433_RS06950	COG1802	Transcriptional regulator
I2433_RS06980	COG0270	DNA (cytosine-5-)-methyltransferase activity
I2433_RS06985	COG1475	DNA binding
I2433_RS07045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2433_RS07045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2433_RS07070	COG1191	sigma factor activity
I2433_RS07110	COG1316	TRANSCRIPTIONal
I2433_RS07130	COG0024	Methionine aminopeptidase
I2433_RS07135	COG4109	DRTGG domain
I2433_RS07140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2433_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
I2433_RS07170	COG1904	glucuronate isomerase
I2433_RS07175	COG0800	Aldolase
I2433_RS07180	COG2186	Transcriptional regulator
I2433_RS07185	COG3250	beta-galactosidase activity
I2433_RS07195	COG2211	Major facilitator Superfamily
I2433_RS07215	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I2433_RS07215	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I2433_RS07225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I2433_RS07230	COG1956	GAF domain-containing protein
I2433_RS07250	COG0513	Belongs to the DEAD box helicase family
I2433_RS07255	COG0726	polysaccharide deacetylase
I2433_RS07275	COG4122	O-methyltransferase activity
I2433_RS07280	COG0546	phosphoglycolate phosphatase activity
I2433_RS07305	COG1187	pseudouridine synthase activity
I2433_RS07340	COG0658	competence protein
I2433_RS07340	COG2333	competence protein COMEC
I2433_RS07350	COG0204	Acyl-transferase
I2433_RS07355	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I2433_RS07370	COG3158	transport of potassium into the cell
I2433_RS07375	COG0513	Belongs to the DEAD box helicase family
I2433_RS07390	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2433_RS07395	COG1181	Belongs to the D-alanine--D-alanine ligase family
I2433_RS07400	COG5433	transposase activity
I2433_RS07410	COG0768	penicillin binding
I2433_RS07415	COG2116	formate transmembrane transporter activity
I2433_RS07425	COG1827	regulation of RNA biosynthetic process
I2433_RS07445	COG1396	sequence-specific DNA binding
I2433_RS07465	COG4698	Protein conserved in bacteria
I2433_RS07470	COG2755	lipolytic protein G-D-S-L family
I2433_RS07485	COG0497	DNA recombination
I2433_RS07490	COG1438	arginine binding
I2433_RS07495	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I2433_RS07515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I2433_RS07520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I2433_RS07525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2433_RS07530	COG1126	abc transporter atp-binding protein
I2433_RS07535	COG0765	amino acid transport
I2433_RS07545	COG4703	Protein of unknown function (DUF1797)
I2433_RS07550	COG0542	response to heat
I2433_RS07555	COG0494	nUDIX hydrolase
I2433_RS07570	COG3599	regulation of cell shape
I2433_RS07590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I2433_RS07600	COG0849	cell division
I2433_RS07625	COG1217	gtp-binding protein TYPA
I2433_RS07635	COG1940	carbohydrate kinase activity
I2433_RS07640	COG4483	Protein conserved in bacteria
I2433_RS07645	COG0783	Belongs to the Dps family
I2433_RS07660	COG4470	Protein conserved in bacteria
I2433_RS07665	COG3480	Lon protease (S16) C-terminal proteolytic domain
I2433_RS07675	COG0742	ribosomal rna small subunit methyltransferase
I2433_RS07685	COG0549	Belongs to the carbamate kinase family
I2433_RS07690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2433_RS07695	COG1288	antiporter activity
I2433_RS07705	COG0454	-acetyltransferase
I2433_RS07715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2433_RS07735	COG2315	Protein conserved in bacteria
I2433_RS07740	COG2972	Histidine kinase
I2433_RS07745	COG4753	response regulator
I2433_RS07745	COG2207	Transcriptional regulator
I2433_RS07755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2433_RS07760	COG0785	Cytochrome C biogenesis protein
I2433_RS07795	COG1114	Component of the transport system for branched-chain amino acids
I2433_RS07820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2433_RS07825	COG2274	protein secretion by the type I secretion system
I2433_RS07885	COG0708	Exodeoxyribonuclease III
I2433_RS07890	COG1393	Belongs to the ArsC family
I2433_RS07895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I2433_RS07930	COG1131	(ABC) transporter
I2433_RS07970	COG0751	glycine-tRNA ligase activity
I2433_RS07980	COG1755	Isoprenylcysteine carboxyl methyltransferase
I2433_RS07990	COG0656	L-ascorbic acid biosynthetic process
I2433_RS08000	COG1283	sodium-dependent phosphate transmembrane transporter activity
I2433_RS08010	COG1879	ABC-type sugar transport system periplasmic component
I2433_RS08015	COG1172	Belongs to the binding-protein-dependent transport system permease family
I2433_RS08025	COG1869	D-ribose catabolic process
I2433_RS08030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2433_RS08035	COG1609	Transcriptional regulator
I2433_RS08050	COG0561	phosphatase activity
I2433_RS08055	COG2860	membrane
I2433_RS08070	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2433_RS08070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2433_RS08075	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2433_RS08080	COG3711	transcriptional antiterminator
I2433_RS08120	COG2217	Heavy metal translocating P-type atpase
I2433_RS08140	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I2433_RS08150	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I2433_RS08155	COG0195	Participates in both transcription termination and antitermination
I2433_RS08190	COG4473	ABC transporter
I2433_RS08195	COG1131	(ABC) transporter
I2433_RS08205	COG0537	adenosine 5'-monophosphoramidase activity
I2433_RS08215	COG1316	TRANSCRIPTIONal
I2433_RS08225	COG0802	atpase or kinase
I2433_RS08230	COG2252	PERMEase
I2433_RS08235	COG0561	phosphatase activity
I2433_RS08245	COG3715	PTS system
I2433_RS08250	COG3716	PTS system mannose fructose sorbose family IID component
I2433_RS08265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I2433_RS08275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I2433_RS08280	COG0439	Biotin carboxylase
I2433_RS08295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2433_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
I2433_RS08305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I2433_RS08310	COG2070	2-Nitropropane dioxygenase
I2433_RS08320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I2433_RS08330	COG1024	Enoyl-CoA hydratase
I2433_RS08335	COG0484	heat shock protein binding
I2433_RS08360	COG1876	peptidase activity
I2433_RS08365	COG0588	phosphoglycerate mutase activity
I2433_RS08370	COG2848	UPF0210 protein
I2433_RS08375	COG3830	Belongs to the UPF0237 family
I2433_RS08385	COG2261	transglycosylase associated protein
I2433_RS08390	COG0697	spore germination
I2433_RS08395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I2433_RS08415	COG1335	isochorismatase
I2433_RS08420	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I2433_RS08425	COG0436	Aminotransferase
I2433_RS08435	COG0561	phosphatase activity
I2433_RS08440	COG0252	asparaginase activity
I2433_RS08445	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I2433_RS08450	COG1129	ABC transporter
I2433_RS08465	COG1132	(ABC) transporter
I2433_RS08470	COG4988	ABC transporter
I2433_RS08475	COG1120	ATPase activity
I2433_RS08500	COG3942	CHAP domain
I2433_RS08500	COG1388	LysM domain
I2433_RS08505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I2433_RS08520	COG1482	cell wall glycoprotein biosynthetic process
I2433_RS08525	COG1940	carbohydrate kinase activity
I2433_RS08540	COG1621	beta-fructofuranosidase activity
I2433_RS08545	COG1609	Transcriptional regulator
I2433_RS08570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2433_RS08585	COG2131	deaminase
I2433_RS08590	COG0006	proline dipeptidase activity
I2433_RS08635	COG1194	a g-specific adenine glycosylase
I2433_RS08655	COG3118	belongs to the thioredoxin family
I2433_RS08660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2433_RS08670	COG1286	toxin biosynthetic process
I2433_RS08685	COG0681	Belongs to the peptidase S26 family
I2433_RS08690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I2433_RS08705	COG1882	Formate acetyltransferase
I2433_RS08715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2433_RS08725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2433_RS08735	COG2814	Major facilitator Superfamily
I2433_RS08740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2433_RS08745	COG2936	dipeptidyl-peptidase activity
I2433_RS08780	COG5002	protein histidine kinase activity
I2433_RS08795	COG1598	PFAM Uncharacterised protein family UPF0150
I2433_RS08815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I2433_RS08835	COG2081	HI0933 family
I2433_RS08865	COG1214	PFAM Peptidase M22, glycoprotease
I2433_RS08870	COG5503	Protein of unknown function (DUF1447)
I2433_RS08885	COG4608	Belongs to the ABC transporter superfamily
I2433_RS08890	COG0444	Belongs to the ABC transporter superfamily
I2433_RS08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2433_RS08900	COG0601	transmembrane transport
I2433_RS08905	COG4166	transmembrane transport
I2433_RS08910	COG0174	glutamine synthetase
I2433_RS08915	COG0789	Transcriptional regulator
I2433_RS08930	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I2433_RS08965	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2433_RS08980	COG1564	THIamine pyrophosphokinase
I2433_RS09005	COG0084	hydrolase, TatD family'
I2433_RS09010	COG1737	Transcriptional regulator
I2433_RS09015	COG3458	cephalosporin-C deacetylase activity
I2433_RS09025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2433_RS09035	COG2731	YhcH YjgK YiaL family protein
I2433_RS09040	COG0395	ABC-type sugar transport system, permease component
I2433_RS09045	COG1175	transmembrane transport
I2433_RS09175	COG0542	response to heat
I2433_RS09275	COG2190	(PTS) system
I2433_RS09275	COG1263	PTS System
I2433_RS09275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2433_RS09280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2433_RS09280	COG2190	(PTS) system
I2433_RS09280	COG1263	PTS System
I2433_RS09320	COG1847	R3H domain protein
I2433_RS09380	COG0756	dUTP diphosphatase activity
I2433_RS09390	COG1132	(ABC) transporter
I2433_RS09395	COG1132	(ABC) transporter
I2433_RS09415	COG0705	Rhomboid family
I2433_RS09415	COG0457	Tetratricopeptide repeat
I2433_RS09420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I2433_RS09515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I2433_RS09520	COG1396	sequence-specific DNA binding
I2433_RS09630	COG0270	DNA (cytosine-5-)-methyltransferase activity
I2433_RS09665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I2433_RS09670	COG0512	Glutamine amidotransferase of anthranilate synthase
I2433_RS09675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I2433_RS09715	COG1132	(ABC) transporter
I2433_RS09755	COG1882	Formate acetyltransferase
I2433_RS09760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2433_RS09765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2433_RS09770	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2433_RS09780	COG1349	DNA-binding transcription factor activity
I2433_RS09785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2433_RS09850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I2433_RS09855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I2433_RS09860	COG1428	Deoxynucleoside kinase
I2433_RS09875	COG4120	Belongs to the binding-protein-dependent transport system permease family
I2433_RS09895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2433_RS09900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2433_RS09910	COG1363	Peptidase, m42
I2433_RS09915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I2433_RS09940	COG3022	response to hydroperoxide
I2433_RS09945	COG0602	queuosine metabolic process
I2433_RS09965	COG1328	CTP reductase activity
I2433_RS09990	COG1393	Belongs to the ArsC family
I2433_RS10020	COG0519	Catalyzes the synthesis of GMP from XMP
I2433_RS10025	COG0632	four-way junction helicase activity
I2433_RS10030	COG2814	Major facilitator Superfamily
I2433_RS10040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I2433_RS10050	COG1438	arginine binding
I2433_RS10055	COG0018	arginyl-trna synthetase
I2433_RS10065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2433_RS10070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2433_RS10075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2433_RS10090	COG1131	(ABC) transporter
I2433_RS10115	COG0124	histidyl-tRNA synthetase
I2433_RS10125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2433_RS10150	COG0494	nUDIX hydrolase
I2433_RS10170	COG1511	domain protein
I2433_RS10210	COG0305	Participates in initiation and elongation during chromosome replication
I2433_RS10230	COG2816	NAD+ diphosphatase activity
I2433_RS10240	COG1760	l-serine dehydratase
I2433_RS10245	COG1760	l-serine dehydratase
I2433_RS10275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I2433_RS10285	COG0612	Peptidase, M16
I2433_RS10295	COG2501	S4 domain
I2433_RS10330	COG0516	GMP reductase activity
I2433_RS10330	COG0517	IMP dehydrogenase activity
I2433_RS10340	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2433_RS10345	COG0488	(ABC) transporter
I2433_RS10380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I2433_RS10385	COG1475	DNA binding