locus-tag	class	description
I2434_RS00010	COG0592	DNA-directed DNA polymerase activity
I2434_RS00025	COG0012	GTP binding
I2434_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
I2434_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I2434_RS00040	COG2244	polysaccharide biosynthetic process
I2434_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I2434_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2434_RS00080	COG0531	amino acid
I2434_RS00200	COG3942	CHAP domain
I2434_RS00215	COG0416	fatty acid biosynthetic process
I2434_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2434_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I2434_RS00260	COG0151	Belongs to the GarS family
I2434_RS00265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I2434_RS00285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2434_RS00305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I2434_RS00320	COG1012	belongs to the aldehyde dehydrogenase family
I2434_RS00320	COG1454	alcohol dehydrogenase
I2434_RS00325	COG1063	alcohol dehydrogenase
I2434_RS00330	COG1064	alcohol dehydrogenase
I2434_RS00335	COG1132	(ABC) transporter
I2434_RS00340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I2434_RS00350	COG1396	sequence-specific DNA binding
I2434_RS00355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I2434_RS00365	COG0051	transcription antitermination factor activity, RNA binding
I2434_RS00380	COG0089	rRNA binding
I2434_RS00470	COG0201	protein transport
I2434_RS00505	COG0203	ribosomal protein L17
I2434_RS00605	COG0582	viral genome integration into host DNA
I2434_RS00615	COG2946	Replication initiation factor
I2434_RS00625	COG1674	ftsk spoiiie
I2434_RS00665	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I2434_RS00680	COG1121	(ABC) transporter
I2434_RS00685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2434_RS00695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2434_RS00695	COG4499	WXG100 protein secretion system (Wss), protein YukC
I2434_RS00705	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I2434_RS00745	COG1136	(ABC) transporter
I2434_RS00750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I2434_RS00755	COG1459	type II secretion system
I2434_RS00760	COG4537	Required for transformation and DNA binding
I2434_RS00805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2434_RS00820	COG3959	Transketolase, thiamine diphosphate binding domain
I2434_RS00825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I2434_RS00830	COG3590	peptidase
I2434_RS00840	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I2434_RS00865	COG0450	alkyl hydroperoxide reductase
I2434_RS00885	COG4463	regulation of RNA biosynthetic process
I2434_RS00940	COG1051	belongs to the nudix hydrolase family
I2434_RS00945	COG1396	sequence-specific DNA binding
I2434_RS00965	COG1116	anion transmembrane transporter activity
I2434_RS00985	COG0564	pseudouridine synthase activity
I2434_RS01005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2434_RS01045	COG3037	sugar-specific permease SgaT UlaA
I2434_RS01065	COG3623	hexulose-6-phosphate isomerase
I2434_RS01090	COG3448	diguanylate cyclase activity
I2434_RS01090	COG4175	Glycine betaine
I2434_RS01100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2434_RS01100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2434_RS01105	COG1832	CoA-binding protein
I2434_RS01160	COG1268	BioY protein
I2434_RS01165	COG1234	tRNA 3'-trailer cleavage
I2434_RS01180	COG5433	transposase activity
I2434_RS01195	COG1215	transferase activity, transferring glycosyl groups
I2434_RS01225	COG3711	transcriptional antiterminator
I2434_RS01225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2434_RS01235	COG3730	PTS system glucitol sorbitol-specific
I2434_RS01240	COG3732	PTS system glucitol sorbitol-specific
I2434_RS01270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I2434_RS01275	COG0705	Rhomboid family
I2434_RS01275	COG0457	Tetratricopeptide repeat
I2434_RS01295	COG1132	(ABC) transporter
I2434_RS01300	COG1132	(ABC) transporter
I2434_RS01310	COG0756	dUTP diphosphatase activity
I2434_RS01365	COG1847	R3H domain protein
I2434_RS01405	COG1263	PTS System
I2434_RS01405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2434_RS01405	COG2190	(PTS) system
I2434_RS01410	COG2190	(PTS) system
I2434_RS01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2434_RS01410	COG1263	PTS System
I2434_RS01435	COG1175	transmembrane transport
I2434_RS01440	COG0395	ABC-type sugar transport system, permease component
I2434_RS01445	COG2731	YhcH YjgK YiaL family protein
I2434_RS01455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2434_RS01465	COG3458	cephalosporin-C deacetylase activity
I2434_RS01470	COG1737	Transcriptional regulator
I2434_RS01475	COG0084	hydrolase, TatD family'
I2434_RS01500	COG1564	THIamine pyrophosphokinase
I2434_RS01515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2434_RS01545	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I2434_RS01560	COG0789	Transcriptional regulator
I2434_RS01565	COG0174	glutamine synthetase
I2434_RS01570	COG4166	transmembrane transport
I2434_RS01575	COG0601	transmembrane transport
I2434_RS01580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2434_RS01585	COG0444	Belongs to the ABC transporter superfamily
I2434_RS01590	COG4608	Belongs to the ABC transporter superfamily
I2434_RS01605	COG1214	PFAM Peptidase M22, glycoprotease
I2434_RS01620	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I2434_RS01635	COG2081	HI0933 family
I2434_RS01650	COG0789	Transcriptional regulator
I2434_RS01655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I2434_RS01670	COG5002	protein histidine kinase activity
I2434_RS01710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2434_RS01715	COG2814	Major facilitator Superfamily
I2434_RS01725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2434_RS01735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2434_RS01745	COG1882	Formate acetyltransferase
I2434_RS01760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I2434_RS01765	COG0681	Belongs to the peptidase S26 family
I2434_RS01780	COG1286	toxin biosynthetic process
I2434_RS01785	COG1193	negative regulation of DNA recombination
I2434_RS01790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2434_RS01795	COG3118	belongs to the thioredoxin family
I2434_RS01810	COG1194	a g-specific adenine glycosylase
I2434_RS01850	COG0006	proline dipeptidase activity
I2434_RS01855	COG2131	deaminase
I2434_RS01895	COG1609	Transcriptional regulator
I2434_RS01900	COG1621	beta-fructofuranosidase activity
I2434_RS01905	COG1263	PTS System
I2434_RS01905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2434_RS01905	COG2190	(PTS) system
I2434_RS01915	COG1940	carbohydrate kinase activity
I2434_RS01920	COG1482	cell wall glycoprotein biosynthetic process
I2434_RS01925	COG0653	protein targeting
I2434_RS01940	COG3942	CHAP domain
I2434_RS01940	COG1388	LysM domain
I2434_RS01965	COG1120	ATPase activity
I2434_RS01970	COG4988	ABC transporter
I2434_RS01975	COG1132	(ABC) transporter
I2434_RS01990	COG1129	ABC transporter
I2434_RS01995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I2434_RS02000	COG0252	asparaginase activity
I2434_RS02005	COG0561	phosphatase activity
I2434_RS02015	COG0436	Aminotransferase
I2434_RS02020	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I2434_RS02025	COG1335	isochorismatase
I2434_RS02040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I2434_RS02045	COG0697	spore germination
I2434_RS02050	COG2261	transglycosylase associated protein
I2434_RS02060	COG3830	Belongs to the UPF0237 family
I2434_RS02070	COG0588	phosphoglycerate mutase activity
I2434_RS02075	COG1876	peptidase activity
I2434_RS02085	COG1420	regulation of RNA biosynthetic process
I2434_RS02100	COG0484	heat shock protein binding
I2434_RS02105	COG1024	Enoyl-CoA hydratase
I2434_RS02115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I2434_RS02125	COG2070	2-Nitropropane dioxygenase
I2434_RS02130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I2434_RS02135	COG1028	Short-chain dehydrogenase reductase Sdr
I2434_RS02140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2434_RS02155	COG0439	Biotin carboxylase
I2434_RS02160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I2434_RS02185	COG3716	PTS system mannose fructose sorbose family IID component
I2434_RS02190	COG3715	PTS system
I2434_RS02205	COG0561	phosphatase activity
I2434_RS02210	COG2252	PERMEase
I2434_RS02215	COG0802	atpase or kinase
I2434_RS02225	COG1316	TRANSCRIPTIONal
I2434_RS02235	COG0537	adenosine 5'-monophosphoramidase activity
I2434_RS02245	COG1131	(ABC) transporter
I2434_RS02250	COG4473	ABC transporter
I2434_RS02285	COG0195	Participates in both transcription termination and antitermination
I2434_RS02290	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I2434_RS02320	COG2217	Heavy metal translocating P-type atpase
I2434_RS02340	COG0698	ribose 5-phosphate isomerase
I2434_RS02360	COG3711	transcriptional antiterminator
I2434_RS02365	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2434_RS02370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2434_RS02370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2434_RS02375	COG2723	6-phospho-beta-galactosidase activity
I2434_RS02385	COG2860	membrane
I2434_RS02390	COG0561	phosphatase activity
I2434_RS02405	COG1609	Transcriptional regulator
I2434_RS02410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2434_RS02415	COG1869	D-ribose catabolic process
I2434_RS02425	COG1172	Belongs to the binding-protein-dependent transport system permease family
I2434_RS02430	COG1879	ABC-type sugar transport system periplasmic component
I2434_RS02440	COG1283	sodium-dependent phosphate transmembrane transporter activity
I2434_RS02450	COG0656	L-ascorbic acid biosynthetic process
I2434_RS02460	COG1755	Isoprenylcysteine carboxyl methyltransferase
I2434_RS02510	COG1131	(ABC) transporter
I2434_RS02560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I2434_RS02565	COG1393	Belongs to the ArsC family
I2434_RS02580	COG0708	Exodeoxyribonuclease III
I2434_RS02640	COG2274	protein secretion by the type I secretion system
I2434_RS02645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2434_RS02670	COG1114	Component of the transport system for branched-chain amino acids
I2434_RS02805	COG1518	maintenance of DNA repeat elements
I2434_RS02810	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I2434_RS02815	COG0785	Cytochrome C biogenesis protein
I2434_RS02820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2434_RS02830	COG2207	Transcriptional regulator
I2434_RS02830	COG4753	response regulator
I2434_RS02835	COG2972	Histidine kinase
I2434_RS02840	COG2315	Protein conserved in bacteria
I2434_RS02875	COG0454	-acetyltransferase
I2434_RS02885	COG1288	antiporter activity
I2434_RS02890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2434_RS02895	COG0549	Belongs to the carbamate kinase family
I2434_RS02905	COG0742	ribosomal rna small subunit methyltransferase
I2434_RS02915	COG3480	Lon protease (S16) C-terminal proteolytic domain
I2434_RS02920	COG4470	Protein conserved in bacteria
I2434_RS02935	COG0783	Belongs to the Dps family
I2434_RS02940	COG4483	Protein conserved in bacteria
I2434_RS02945	COG1940	carbohydrate kinase activity
I2434_RS02950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I2434_RS02955	COG1217	gtp-binding protein TYPA
I2434_RS02980	COG0849	cell division
I2434_RS02990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I2434_RS03010	COG3599	regulation of cell shape
I2434_RS03025	COG0494	nUDIX hydrolase
I2434_RS03030	COG0542	response to heat
I2434_RS03035	COG4703	Protein of unknown function (DUF1797)
I2434_RS03045	COG0765	amino acid transport
I2434_RS03050	COG1126	abc transporter atp-binding protein
I2434_RS03055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2434_RS03065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I2434_RS03085	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I2434_RS03090	COG1438	arginine binding
I2434_RS03095	COG0497	DNA recombination
I2434_RS03110	COG2755	lipolytic protein G-D-S-L family
I2434_RS03115	COG4698	Protein conserved in bacteria
I2434_RS03135	COG1396	sequence-specific DNA binding
I2434_RS03145	COG0167	dihydroorotate dehydrogenase activity
I2434_RS03155	COG1827	regulation of RNA biosynthetic process
I2434_RS03165	COG2116	formate transmembrane transporter activity
I2434_RS03170	COG0768	penicillin binding
I2434_RS03185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2434_RS03205	COG0513	Belongs to the DEAD box helicase family
I2434_RS03220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I2434_RS03225	COG0204	Acyl-transferase
I2434_RS03230	COG1555	photosystem II stabilization
I2434_RS03235	COG2333	competence protein COMEC
I2434_RS03235	COG0658	competence protein
I2434_RS03270	COG1187	pseudouridine synthase activity
I2434_RS03295	COG0546	phosphoglycolate phosphatase activity
I2434_RS03300	COG4122	O-methyltransferase activity
I2434_RS03305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I2434_RS03320	COG0726	polysaccharide deacetylase
I2434_RS03325	COG0513	Belongs to the DEAD box helicase family
I2434_RS03345	COG1956	GAF domain-containing protein
I2434_RS03350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I2434_RS03360	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I2434_RS03360	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I2434_RS03385	COG2211	Major facilitator Superfamily
I2434_RS03395	COG3250	beta-galactosidase activity
I2434_RS03400	COG2186	Transcriptional regulator
I2434_RS03405	COG0800	Aldolase
I2434_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
I2434_RS03440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2434_RS03445	COG4109	DRTGG domain
I2434_RS03450	COG0024	Methionine aminopeptidase
I2434_RS03460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I2434_RS03470	COG1316	TRANSCRIPTIONal
I2434_RS03475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I2434_RS03500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I2434_RS03575	COG1373	ATPase (AAA superfamily
I2434_RS03585	COG0588	phosphoglycerate mutase activity
I2434_RS03595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I2434_RS03600	COG3859	Proton-coupled thiamine transporter YuaJ
I2434_RS03625	COG0386	Belongs to the glutathione peroxidase family
I2434_RS03630	COG1164	Oligoendopeptidase f
I2434_RS03640	COG0772	Belongs to the SEDS family
I2434_RS03650	COG1131	(ABC) transporter
I2434_RS03665	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I2434_RS03685	COG2884	Cell division ATP-binding protein ftsE
I2434_RS03690	COG2177	Part of the ABC transporter FtsEX involved in
I2434_RS03700	COG1199	ATP-dependent helicase activity
I2434_RS03700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2434_RS03700	COG1199	ATP-dependent helicase activity
I2434_RS03700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2434_RS03710	COG0436	Aminotransferase
I2434_RS03715	COG0017	Asparaginyl-tRNA synthetase
I2434_RS03750	COG2188	Transcriptional regulator
I2434_RS03755	COG2222	sugar isomerase
I2434_RS03760	COG3684	Belongs to the aldolase LacD family
I2434_RS03765	COG2188	Transcriptional regulator
I2434_RS03775	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2434_RS03775	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2434_RS03780	COG3715	PTS system
I2434_RS03785	COG3716	PTS system mannose fructose sorbose family IID component
I2434_RS03805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I2434_RS03810	COG2153	protein acetylation
I2434_RS03820	COG0716	FMN binding
I2434_RS03830	COG0038	chloride channel
I2434_RS03850	COG1476	TRANSCRIPTIONal
I2434_RS03870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2434_RS03875	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I2434_RS03880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2434_RS03890	COG1012	belongs to the aldehyde dehydrogenase family
I2434_RS03895	COG0772	Belongs to the SEDS family
I2434_RS03945	COG4708	membrane
I2434_RS03955	COG1597	lipid kinase activity
I2434_RS03960	COG1523	belongs to the glycosyl hydrolase 13 family
I2434_RS03965	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I2434_RS03970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2434_RS03975	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2434_RS03985	COG0058	SHG alpha-glucan phosphorylase activity
I2434_RS04060	COG0577	efflux transmembrane transporter activity
I2434_RS04075	COG1309	transcriptional regulator
I2434_RS04125	COG1523	belongs to the glycosyl hydrolase 13 family
I2434_RS04130	COG1595	DNA-templated transcription, initiation
I2434_RS04170	COG1074	ATP-dependent DNA helicase activity
I2434_RS04175	COG0436	Aminotransferase
I2434_RS04180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2434_RS04190	COG1970	mechanosensitive ion channel activity
I2434_RS04195	COG0358	DNA primase activity
I2434_RS04200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I2434_RS04205	COG2151	metal-sulfur cluster biosynthetic enzyme
I2434_RS04210	COG1091	dTDP-4-dehydrorhamnose reductase activity
I2434_RS04220	COG0463	Glycosyl transferase, family 2
I2434_RS04245	COG0463	Glycosyl transferase, family 2
I2434_RS04265	COG0297	glycogen (starch) synthase activity
I2434_RS04270	COG1368	sulfuric ester hydrolase activity
I2434_RS04275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2434_RS04325	COG1368	sulfuric ester hydrolase activity
I2434_RS04330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I2434_RS04345	COG3679	Belongs to the UPF0342 family
I2434_RS04350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2434_RS04360	COG1104	cysteine desulfurase activity
I2434_RS04400	COG1131	(ABC) transporter
I2434_RS04405	COG1725	Transcriptional regulator
I2434_RS04420	COG0469	pyruvate kinase activity
I2434_RS04435	COG2824	Alkylphosphonate utilization operon protein PhnA
I2434_RS04440	COG0765	amino acid transport
I2434_RS04445	COG1126	abc transporter atp-binding protein
I2434_RS04450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2434_RS04455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I2434_RS04460	COG1115	amino acid carrier protein
I2434_RS04510	COG4591	ABC-type transport system involved in lipoprotein release permease component
I2434_RS04510	COG1136	(ABC) transporter
I2434_RS04540	COG0196	riboflavin kinase activity
I2434_RS04555	COG0483	inositol monophosphate 1-phosphatase activity
I2434_RS04560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2434_RS04560	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I2434_RS04570	COG0573	inorganic phosphate transmembrane transporter activity
I2434_RS04575	COG0581	inorganic phosphate transmembrane transporter activity
I2434_RS04590	COG0704	Plays a role in the regulation of phosphate uptake
I2434_RS04600	COG0745	RESPONSE REGULATOR receiver
I2434_RS04605	COG5002	protein histidine kinase activity
I2434_RS04635	COG1072	(Pantothenic acid kinase))
I2434_RS04640	COG2813	Specifically methylates the guanine in position
I2434_RS04645	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I2434_RS04660	COG1744	ABC transporter substrate-binding protein PnrA-like
I2434_RS04665	COG3845	ABC transporter
I2434_RS04670	COG4603	Belongs to the binding-protein-dependent transport system permease family
I2434_RS04675	COG1079	Belongs to the binding-protein-dependent transport system permease family
I2434_RS04680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2434_RS04685	COG4684	Psort location CytoplasmicMembrane, score
I2434_RS04690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I2434_RS04710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I2434_RS04715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I2434_RS04720	COG1328	CTP reductase activity
I2434_RS04720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I2434_RS04725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2434_RS04740	COG0488	(ABC) transporter
I2434_RS04750	COG1597	lipid kinase activity
I2434_RS04755	COG1272	protein, Hemolysin III
I2434_RS04765	COG2226	methyltransferase
I2434_RS04790	COG1131	(ABC) transporter
I2434_RS04815	COG0577	efflux transmembrane transporter activity
I2434_RS04815	COG1136	(ABC) transporter
I2434_RS04820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2434_RS04830	COG0758	DNA mediated transformation
I2434_RS04835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2434_RS04850	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I2434_RS04855	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I2434_RS04875	COG2851	Citrate transporter
I2434_RS04885	COG0511	ligase activity, forming carbon-carbon bonds
I2434_RS04890	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I2434_RS04895	COG3052	prosthetic group binding
I2434_RS04925	COG1136	(ABC) transporter
I2434_RS04930	COG0577	efflux transmembrane transporter activity
I2434_RS04935	COG0745	RESPONSE REGULATOR receiver
I2434_RS04940	COG5002	protein histidine kinase activity
I2434_RS04945	COG4974	Belongs to the 'phage' integrase family
I2434_RS04955	COG1396	sequence-specific DNA binding
I2434_RS04960	COG0582	viral genome integration into host DNA
I2434_RS04985	COG2188	Transcriptional regulator
I2434_RS04995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I2434_RS05015	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2434_RS05020	COG0346	lactoylglutathione lyase activity
I2434_RS05025	COG3764	Sortase (surface protein transpeptidase)
I2434_RS05055	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I2434_RS05060	COG1247	-acetyltransferase
I2434_RS05065	COG0009	L-threonylcarbamoyladenylate synthase
I2434_RS05070	COG2890	protein-(glutamine-N5) methyltransferase activity
I2434_RS05085	COG1942	4-Oxalocrotonate Tautomerase
I2434_RS05095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2434_RS05105	COG1174	glycine betaine transport
I2434_RS05120	COG4221	oxidoreductase activity
I2434_RS05125	COG0280	phosphate acetyltransferase
I2434_RS05130	COG0564	pseudouridine synthase activity
I2434_RS05140	COG2357	RelA SpoT domain protein
I2434_RS05155	COG1104	cysteine desulfurase activity
I2434_RS05170	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I2434_RS05180	COG0628	permease
I2434_RS05200	COG1177	transmembrane transport
I2434_RS05205	COG1176	ABC-type spermidine putrescine transport system, permease component I
I2434_RS05215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I2434_RS05220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I2434_RS05235	COG0302	gtp cyclohydrolase
I2434_RS05240	COG0285	dihydrofolate synthase activity
I2434_RS05250	COG0460	homoserine dehydrogenase
I2434_RS05255	COG0726	polysaccharide deacetylase
I2434_RS05265	COG0105	UTP biosynthetic process
I2434_RS05290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I2434_RS05305	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I2434_RS05315	COG3425	synthase
I2434_RS05345	COG1132	(ABC) transporter
I2434_RS05350	COG1132	(ABC) transporter
I2434_RS05355	COG0737	Belongs to the 5'-nucleotidase family
I2434_RS05360	COG0242	peptide deformylase activity
I2434_RS05365	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I2434_RS05370	COG1132	(ABC) transporter
I2434_RS05380	COG0488	(ABC) transporter
I2434_RS05400	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2434_RS05400	COG1388	LysM domain
I2434_RS05420	COG1476	TRANSCRIPTIONal
I2434_RS05435	COG0693	protein deglycase activity
I2434_RS05450	COG1388	LysM domain
I2434_RS05450	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2434_RS05455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2434_RS05455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2434_RS05455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2434_RS05460	COG1105	Belongs to the carbohydrate kinase PfkB family
I2434_RS05465	COG1349	DNA-binding transcription factor activity
I2434_RS05485	COG0336	Belongs to the RNA methyltransferase TrmD family
I2434_RS05490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I2434_RS05510	COG1837	Belongs to the UPF0109 family
I2434_RS05525	COG0577	efflux transmembrane transporter activity
I2434_RS05530	COG1136	(ABC) transporter
I2434_RS05535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2434_RS05545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I2434_RS05575	COG0564	pseudouridine synthase activity
I2434_RS05585	COG0583	DNA-binding transcription factor activity
I2434_RS05590	COG5433	transposase activity
I2434_RS05595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I2434_RS05655	COG0539	negative regulation of cytoplasmic translation
I2434_RS05675	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I2434_RS05690	COG0187	DNA topoisomerase II activity
I2434_RS05705	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I2434_RS05715	COG0765	amino acid transport
I2434_RS05735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I2434_RS05740	COG0284	orotidine-5'-phosphate decarboxylase activity
I2434_RS05750	COG0583	DNA-binding transcription factor activity
I2434_RS05770	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I2434_RS05835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2434_RS05855	COG4753	response regulator
I2434_RS05855	COG2207	Transcriptional regulator
I2434_RS05860	COG2972	Histidine kinase
I2434_RS05865	COG3716	PTS system mannose fructose sorbose family IID component
I2434_RS05870	COG3715	PTS system
I2434_RS05895	COG0481	GTPase activity
I2434_RS05960	COG0647	UMP catabolic process
I2434_RS05970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I2434_RS05990	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I2434_RS05995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2434_RS06000	COG3442	glutamine amidotransferase
I2434_RS06005	COG0095	Lipoate-protein ligase
I2434_RS06015	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2434_RS06020	COG0022	dehydrogenase e1 component
I2434_RS06020	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2434_RS06025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I2434_RS06030	COG0488	(ABC) transporter
I2434_RS06045	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I2434_RS06060	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I2434_RS06065	COG0457	Tetratricopeptide repeat
I2434_RS06070	COG0628	permease
I2434_RS06075	COG1051	belongs to the nudix hydrolase family
I2434_RS06080	COG1088	dTDP-glucose 4,6-dehydratase activity
I2434_RS06090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I2434_RS06095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I2434_RS06105	COG2384	SAM-dependent methyltransferase
I2434_RS06110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I2434_RS06130	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I2434_RS06130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I2434_RS06135	COG0300	oxidoreductase activity
I2434_RS06145	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2434_RS06150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I2434_RS06170	COG0058	SHG alpha-glucan phosphorylase activity
I2434_RS06175	COG1640	4-alpha-glucanotransferase
I2434_RS06180	COG1609	Transcriptional regulator
I2434_RS06190	COG1175	transmembrane transport
I2434_RS06195	COG3833	ABC-type maltose transport systems, permease component
I2434_RS06205	COG3833	ABC-type maltose transport systems, permease component
I2434_RS06210	COG1175	transmembrane transport
I2434_RS06220	COG0366	Alpha amylase catalytic
I2434_RS06225	COG2182	Extracellular solute-binding protein
I2434_RS06230	COG0657	acetylesterase activity
I2434_RS06235	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I2434_RS06245	COG1696	Membrane protein involved in D-alanine export
I2434_RS06260	COG0556	nucleotide-excision repair
I2434_RS06265	COG0765	amino acid transport
I2434_RS06270	COG1126	abc transporter atp-binding protein
I2434_RS06280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2434_RS06290	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2434_RS06300	COG3711	transcriptional antiterminator
I2434_RS06300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2434_RS06310	COG2723	6-phospho-beta-galactosidase activity
I2434_RS06335	COG2309	aminopeptidase activity
I2434_RS06340	COG1187	pseudouridine synthase activity
I2434_RS06350	COG2814	Major facilitator Superfamily
I2434_RS06385	COG5492	domain, Protein
I2434_RS06390	COG0800	Aldolase
I2434_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
I2434_RS06420	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2434_RS06425	COG3715	PTS system
I2434_RS06430	COG3716	PTS system mannose fructose sorbose family IID component
I2434_RS06435	COG1609	Transcriptional regulator
I2434_RS06470	COG1078	dGTPase activity
I2434_RS06510	COG1191	sigma factor activity
I2434_RS06560	COG2814	Major facilitator Superfamily
I2434_RS06575	COG4443	Transcriptional Coactivator p15 (PC4)
I2434_RS06585	COG0826	peptidase U32
I2434_RS06625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I2434_RS06640	COG3091	SprT-like family
I2434_RS06645	COG2183	response to ionizing radiation
I2434_RS06655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I2434_RS06665	COG0573	inorganic phosphate transmembrane transporter activity
I2434_RS06670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I2434_RS06675	COG5002	protein histidine kinase activity
I2434_RS06680	COG0745	RESPONSE REGULATOR receiver
I2434_RS06690	COG0701	Predicted permease
I2434_RS06695	COG3689	TIGRFAM TIGR03943 family protein
I2434_RS06705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2434_RS06705	COG2190	(PTS) system
I2434_RS06705	COG1263	PTS System
I2434_RS06710	COG3711	transcriptional antiterminator
I2434_RS06715	COG0552	protein localization to endoplasmic reticulum
I2434_RS06720	COG0561	phosphatase activity
I2434_RS06725	COG0561	phosphatase activity
I2434_RS06755	COG1196	nuclear chromosome segregation
I2434_RS06760	COG0571	ribonuclease III activity
I2434_RS06780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I2434_RS06785	COG5002	protein histidine kinase activity
I2434_RS06790	COG0745	RESPONSE REGULATOR receiver
I2434_RS06805	COG0183	Belongs to the thiolase family
I2434_RS06825	COG4555	ABC transporter
I2434_RS06840	COG1131	(ABC) transporter
I2434_RS06870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I2434_RS06875	COG0438	transferase activity, transferring glycosyl groups
I2434_RS06890	COG1609	Transcriptional regulator
I2434_RS06895	COG0006	proline dipeptidase activity
I2434_RS06900	COG2274	protein secretion by the type I secretion system
I2434_RS06915	COG0463	Glycosyl transferase, family 2
I2434_RS06925	COG0557	exoribonuclease II activity
I2434_RS06935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2434_RS06965	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2434_RS06970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2434_RS06975	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2434_RS06980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2434_RS06990	COG1940	carbohydrate kinase activity
I2434_RS07030	COG1136	(ABC) transporter
I2434_RS07080	COG0613	PHP domain protein
I2434_RS07085	COG0542	response to heat
I2434_RS07090	COG1396	sequence-specific DNA binding
I2434_RS07120	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I2434_RS07140	COG1396	sequence-specific DNA binding
I2434_RS07205	COG0270	DNA (cytosine-5-)-methyltransferase activity
I2434_RS07225	COG1136	(ABC) transporter
I2434_RS07230	COG1770	oligopeptidase
I2434_RS07260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I2434_RS07275	COG1573	uracil-dna glycosylase
I2434_RS07280	COG1702	phosphate starvation-inducible protein PhoH
I2434_RS07315	COG0444	Belongs to the ABC transporter superfamily
I2434_RS07320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2434_RS07325	COG0601	transmembrane transport
I2434_RS07330	COG0747	negative chemotaxis
I2434_RS07395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I2434_RS07415	COG0673	inositol 2-dehydrogenase activity
I2434_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
I2434_RS07445	COG1376	ErfK ybiS ycfS ynhG family protein
I2434_RS07465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2434_RS07485	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I2434_RS07485	COG1605	Chorismate mutase
I2434_RS07500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I2434_RS07505	COG3250	beta-galactosidase activity
I2434_RS07510	COG2207	Transcriptional regulator
I2434_RS07510	COG4753	response regulator
I2434_RS07515	COG2972	Histidine kinase
I2434_RS07525	COG1653	transport
I2434_RS07530	COG0395	ABC-type sugar transport system, permease component
I2434_RS07535	COG1175	transmembrane transport
I2434_RS07540	COG1940	carbohydrate kinase activity
I2434_RS07550	COG2723	6-phospho-beta-galactosidase activity
I2434_RS07555	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I2434_RS07555	COG3291	Pkd domain containing protein
I2434_RS07570	COG0383	alpha-mannosidase activity
I2434_RS07575	COG1136	(ABC) transporter
I2434_RS07575	COG0577	efflux transmembrane transporter activity
I2434_RS07630	COG2274	protein secretion by the type I secretion system
I2434_RS07645	COG3290	protein histidine kinase activity
I2434_RS07760	COG1040	competence protein
I2434_RS07765	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I2434_RS07770	COG1739	Uncharacterized protein family UPF0029
I2434_RS07780	COG1098	S1 RNA binding domain
I2434_RS07790	COG2197	response regulator
I2434_RS07795	COG4585	Histidine kinase
I2434_RS07805	COG2815	serine threonine protein kinase
I2434_RS07805	COG0515	serine threonine protein kinase
I2434_RS07815	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2434_RS07815	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2434_RS07820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I2434_RS07825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I2434_RS07845	COG1854	S-ribosylhomocysteine lyase activity
I2434_RS07855	COG0116	Belongs to the methyltransferase superfamily
I2434_RS07880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2434_RS07885	COG3579	cysteine-type endopeptidase activity
I2434_RS07895	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I2434_RS07900	COG1113	amino acid transport
I2434_RS07910	COG0492	ferredoxin-NADP+ reductase activity
I2434_RS07920	COG1126	abc transporter atp-binding protein
I2434_RS07930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2434_RS07940	COG0513	Belongs to the DEAD box helicase family
I2434_RS07950	COG0768	penicillin binding
I2434_RS07990	COG1131	(ABC) transporter
I2434_RS08045	COG1774	PSP1 C-terminal conserved region
I2434_RS08050	COG0470	DNA polymerase III
I2434_RS08060	COG4471	UPF0298 protein
I2434_RS08080	COG2244	polysaccharide biosynthetic process
I2434_RS08090	COG1120	ATPase activity
I2434_RS08095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I2434_RS08100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2434_RS08105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2434_RS08115	COG1227	inorganic diphosphatase activity
I2434_RS08120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2434_RS08125	COG1253	flavin adenine dinucleotide binding
I2434_RS08130	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I2434_RS08140	COG1242	4 iron, 4 sulfur cluster binding
I2434_RS08145	COG0671	phosphoesterase, PA-phosphatase related
I2434_RS08150	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I2434_RS08205	COG1187	pseudouridine synthase activity
I2434_RS08215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I2434_RS08220	COG0582	viral genome integration into host DNA
I2434_RS08260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2434_RS08265	COG1254	Belongs to the acylphosphatase family
I2434_RS08280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I2434_RS08310	COG1484	DNA-dependent DNA replication
I2434_RS08325	COG5002	protein histidine kinase activity
I2434_RS08330	COG0745	RESPONSE REGULATOR receiver
I2434_RS08345	COG1704	LemA family
I2434_RS08355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I2434_RS08360	COG0569	domain protein
I2434_RS08370	COG1114	Component of the transport system for branched-chain amino acids
I2434_RS08385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2434_RS08390	COG1464	Belongs to the NlpA lipoprotein family
I2434_RS08395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2434_RS08405	COG0789	Transcriptional regulator
I2434_RS08415	COG2226	methyltransferase
I2434_RS08420	COG0799	negative regulation of ribosome biogenesis
I2434_RS08425	COG1713	HD superfamily hydrolase involved in NAD metabolism
I2434_RS08430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2434_RS08435	COG1534	Rna-binding protein
I2434_RS08440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2434_RS08445	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I2434_RS08490	COG0444	Belongs to the ABC transporter superfamily
I2434_RS08495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2434_RS08500	COG0601	transmembrane transport
I2434_RS08505	COG4166	transmembrane transport
I2434_RS08510	COG1686	Belongs to the peptidase S11 family
I2434_RS08515	COG1686	Belongs to the peptidase S11 family
I2434_RS08525	COG0719	Fe-S assembly protein
I2434_RS08535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2434_RS08540	COG0719	Fe-S assembly protein
I2434_RS08550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2434_RS08560	COG1968	undecaprenyl-diphosphatase activity
I2434_RS08565	COG0765	amino acid transport
I2434_RS08570	COG1126	abc transporter atp-binding protein
I2434_RS08605	COG0191	fructose-bisphosphate aldolase activity
I2434_RS08635	COG0544	peptidyl-prolyl cis-trans isomerase activity
I2434_RS08640	COG0366	Alpha amylase catalytic
I2434_RS08645	COG0668	transmembrane transport
I2434_RS08655	COG4720	Psort location CytoplasmicMembrane, score
I2434_RS08660	COG0351	phosphomethylpyrimidine kinase
I2434_RS08660	COG0352	thiamine-phosphate diphosphorylase activity
I2434_RS08670	COG0527	aspartate kinase activity
I2434_RS08780	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2434_RS08790	COG1597	lipid kinase activity
I2434_RS08795	COG1609	Transcriptional regulator
I2434_RS08800	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I2434_RS08805	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2434_RS08810	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2434_RS08815	COG2017	converts alpha-aldose to the beta-anomer
I2434_RS08845	COG1674	ftsk spoiiie
I2434_RS08880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I2434_RS08895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2434_RS08905	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I2434_RS08915	COG1045	serine acetyltransferase
I2434_RS08925	COG1185	polyribonucleotide nucleotidyltransferase activity
I2434_RS08945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I2434_RS08950	COG1846	Transcriptional regulator
I2434_RS08965	COG0442	prolyl-tRNA aminoacylation
I2434_RS08975	COG4589	Belongs to the CDS family
I2434_RS08985	COG1862	Preprotein translocase
I2434_RS09000	COG3842	ATPase activity
I2434_RS09025	COG1196	nuclear chromosome segregation
I2434_RS09045	COG2190	(PTS) system
I2434_RS09045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2434_RS09045	COG1263	PTS System
I2434_RS09050	COG1609	Transcriptional regulator
I2434_RS09055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I2434_RS09060	COG2264	protein methyltransferase activity
I2434_RS09085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I2434_RS09090	COG0512	Glutamine amidotransferase of anthranilate synthase
I2434_RS09095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I2434_RS09170	COG1882	Formate acetyltransferase
I2434_RS09175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2434_RS09180	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2434_RS09185	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2434_RS09190	COG2390	Transcriptional regulator
I2434_RS09195	COG1349	DNA-binding transcription factor activity
I2434_RS09200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2434_RS09275	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I2434_RS09280	COG1428	Deoxynucleoside kinase
I2434_RS09295	COG4120	Belongs to the binding-protein-dependent transport system permease family
I2434_RS09320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2434_RS09325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2434_RS09335	COG1363	Peptidase, m42
I2434_RS09340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I2434_RS09370	COG0602	queuosine metabolic process
I2434_RS09390	COG1328	CTP reductase activity
I2434_RS09415	COG1393	Belongs to the ArsC family
I2434_RS09425	COG1546	Belongs to the CinA family
I2434_RS09425	COG1058	Belongs to the CinA family
I2434_RS09445	COG0519	Catalyzes the synthesis of GMP from XMP
I2434_RS09450	COG0632	four-way junction helicase activity
I2434_RS09455	COG2814	Major facilitator Superfamily
I2434_RS09465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I2434_RS09475	COG1438	arginine binding
I2434_RS09480	COG0018	arginyl-trna synthetase
I2434_RS09485	COG0488	(ABC) transporter
I2434_RS09490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2434_RS09495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2434_RS09500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2434_RS09505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I2434_RS09515	COG1131	(ABC) transporter
I2434_RS09535	COG0124	histidyl-tRNA synthetase
I2434_RS09545	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I2434_RS09550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2434_RS09575	COG2197	response regulator
I2434_RS09590	COG1136	(ABC) transporter
I2434_RS09590	COG0577	efflux transmembrane transporter activity
I2434_RS09610	COG0494	nUDIX hydrolase
I2434_RS09630	COG1511	domain protein
I2434_RS09685	COG0488	(ABC) transporter
I2434_RS09690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2434_RS09700	COG0516	GMP reductase activity
I2434_RS09700	COG0517	IMP dehydrogenase activity
I2434_RS09740	COG2501	S4 domain
I2434_RS09750	COG0612	Peptidase, M16
I2434_RS09760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I2434_RS09790	COG1760	l-serine dehydratase
I2434_RS09795	COG1760	l-serine dehydratase
I2434_RS09805	COG2816	NAD+ diphosphatase activity
I2434_RS09825	COG0305	Participates in initiation and elongation during chromosome replication
I2434_RS09850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I2434_RS09855	COG1475	DNA binding