locus-tag	class	description
I2435_RS00010	COG0592	DNA-directed DNA polymerase activity
I2435_RS00025	COG0012	GTP binding
I2435_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
I2435_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I2435_RS00040	COG2244	polysaccharide biosynthetic process
I2435_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I2435_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2435_RS00075	COG0531	amino acid
I2435_RS00195	COG3942	CHAP domain
I2435_RS00210	COG0416	fatty acid biosynthetic process
I2435_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2435_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I2435_RS00255	COG0151	Belongs to the GarS family
I2435_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I2435_RS00285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2435_RS00305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I2435_RS00320	COG1454	alcohol dehydrogenase
I2435_RS00320	COG1012	belongs to the aldehyde dehydrogenase family
I2435_RS00325	COG1063	alcohol dehydrogenase
I2435_RS00330	COG1064	alcohol dehydrogenase
I2435_RS00340	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I2435_RS00350	COG0051	transcription antitermination factor activity, RNA binding
I2435_RS00365	COG0089	rRNA binding
I2435_RS00455	COG0201	protein transport
I2435_RS00490	COG0203	ribosomal protein L17
I2435_RS00590	COG0582	viral genome integration into host DNA
I2435_RS00600	COG2946	Replication initiation factor
I2435_RS00635	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I2435_RS00650	COG1121	(ABC) transporter
I2435_RS00655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2435_RS00665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2435_RS00665	COG4499	WXG100 protein secretion system (Wss), protein YukC
I2435_RS00670	COG0085	RNA polymerase activity
I2435_RS00675	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I2435_RS00715	COG1136	(ABC) transporter
I2435_RS00720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I2435_RS00775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2435_RS00790	COG3959	Transketolase, thiamine diphosphate binding domain
I2435_RS00795	COG3958	Transketolase
I2435_RS00800	COG3590	peptidase
I2435_RS00805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I2435_RS00820	COG0450	alkyl hydroperoxide reductase
I2435_RS00840	COG4463	regulation of RNA biosynthetic process
I2435_RS00845	COG0542	response to heat
I2435_RS00895	COG1051	belongs to the nudix hydrolase family
I2435_RS00900	COG1396	sequence-specific DNA binding
I2435_RS00920	COG4133	protoheme IX ABC transporter activity
I2435_RS00940	COG0564	pseudouridine synthase activity
I2435_RS00960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2435_RS01020	COG1131	(ABC) transporter
I2435_RS01025	COG3037	sugar-specific permease SgaT UlaA
I2435_RS01045	COG3623	hexulose-6-phosphate isomerase
I2435_RS01065	COG5433	transposase activity
I2435_RS01070	COG3448	diguanylate cyclase activity
I2435_RS01070	COG4175	Glycine betaine
I2435_RS01080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2435_RS01080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2435_RS01085	COG1832	CoA-binding protein
I2435_RS01135	COG1268	BioY protein
I2435_RS01140	COG1234	tRNA 3'-trailer cleavage
I2435_RS01165	COG1215	transferase activity, transferring glycosyl groups
I2435_RS01195	COG3711	transcriptional antiterminator
I2435_RS01195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2435_RS01205	COG3730	PTS system glucitol sorbitol-specific
I2435_RS01210	COG3732	PTS system glucitol sorbitol-specific
I2435_RS01240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I2435_RS01245	COG0705	Rhomboid family
I2435_RS01245	COG0457	Tetratricopeptide repeat
I2435_RS01255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I2435_RS01265	COG1132	(ABC) transporter
I2435_RS01270	COG1132	(ABC) transporter
I2435_RS01280	COG5433	transposase activity
I2435_RS01285	COG0756	dUTP diphosphatase activity
I2435_RS01335	COG1131	(ABC) transporter
I2435_RS01370	COG1847	R3H domain protein
I2435_RS01415	COG1263	PTS System
I2435_RS01415	COG2190	(PTS) system
I2435_RS01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2435_RS01420	COG1263	PTS System
I2435_RS01420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2435_RS01420	COG2190	(PTS) system
I2435_RS01455	COG1126	abc transporter atp-binding protein
I2435_RS01460	COG0765	amino acid transport
I2435_RS01475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2435_RS01485	COG0719	Fe-S assembly protein
I2435_RS01490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2435_RS01500	COG0719	Fe-S assembly protein
I2435_RS01510	COG1686	Belongs to the peptidase S11 family
I2435_RS01515	COG1686	Belongs to the peptidase S11 family
I2435_RS01520	COG4166	transmembrane transport
I2435_RS01525	COG0601	transmembrane transport
I2435_RS01530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2435_RS01535	COG0444	Belongs to the ABC transporter superfamily
I2435_RS01650	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I2435_RS01655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2435_RS01660	COG1534	Rna-binding protein
I2435_RS01665	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2435_RS01670	COG1713	HD superfamily hydrolase involved in NAD metabolism
I2435_RS01675	COG0799	negative regulation of ribosome biogenesis
I2435_RS01680	COG2226	methyltransferase
I2435_RS01685	COG1323	Belongs to the UPF0348 family
I2435_RS01690	COG0789	Transcriptional regulator
I2435_RS01700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2435_RS01705	COG1464	Belongs to the NlpA lipoprotein family
I2435_RS01710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2435_RS01725	COG1114	Component of the transport system for branched-chain amino acids
I2435_RS01730	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I2435_RS01735	COG0569	domain protein
I2435_RS01740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I2435_RS01750	COG1704	LemA family
I2435_RS01765	COG0745	RESPONSE REGULATOR receiver
I2435_RS01770	COG5002	protein histidine kinase activity
I2435_RS01785	COG1484	DNA-dependent DNA replication
I2435_RS01815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I2435_RS01830	COG1254	Belongs to the acylphosphatase family
I2435_RS01835	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2435_RS01875	COG0582	viral genome integration into host DNA
I2435_RS01890	COG1187	pseudouridine synthase activity
I2435_RS01955	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I2435_RS01960	COG0671	phosphoesterase, PA-phosphatase related
I2435_RS01965	COG1242	4 iron, 4 sulfur cluster binding
I2435_RS01970	COG3231	kanamycin kinase activity
I2435_RS01975	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I2435_RS01980	COG1253	flavin adenine dinucleotide binding
I2435_RS01985	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2435_RS01990	COG1227	inorganic diphosphatase activity
I2435_RS02000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2435_RS02005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2435_RS02010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I2435_RS02015	COG1120	ATPase activity
I2435_RS02025	COG2244	polysaccharide biosynthetic process
I2435_RS02050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I2435_RS02055	COG0470	DNA polymerase III
I2435_RS02060	COG1774	PSP1 C-terminal conserved region
I2435_RS02115	COG1131	(ABC) transporter
I2435_RS02155	COG0768	penicillin binding
I2435_RS02165	COG0513	Belongs to the DEAD box helicase family
I2435_RS02175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2435_RS02185	COG1126	abc transporter atp-binding protein
I2435_RS02195	COG0492	ferredoxin-NADP+ reductase activity
I2435_RS02200	COG1113	amino acid transport
I2435_RS02205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I2435_RS02210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I2435_RS02215	COG3579	cysteine-type endopeptidase activity
I2435_RS02220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2435_RS02245	COG0116	Belongs to the methyltransferase superfamily
I2435_RS02255	COG1854	S-ribosylhomocysteine lyase activity
I2435_RS02275	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I2435_RS02280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I2435_RS02285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2435_RS02285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2435_RS02295	COG2815	serine threonine protein kinase
I2435_RS02295	COG0515	serine threonine protein kinase
I2435_RS02305	COG4585	Histidine kinase
I2435_RS02310	COG2197	response regulator
I2435_RS02320	COG1098	S1 RNA binding domain
I2435_RS02330	COG1739	Uncharacterized protein family UPF0029
I2435_RS02335	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I2435_RS02340	COG1040	competence protein
I2435_RS02440	COG1396	sequence-specific DNA binding
I2435_RS02575	COG1598	PFAM Uncharacterised protein family UPF0150
I2435_RS02705	COG0860	N-Acetylmuramoyl-L-alanine amidase
I2435_RS02705	COG1388	LysM domain
I2435_RS02755	COG3290	protein histidine kinase activity
I2435_RS02770	COG2274	protein secretion by the type I secretion system
I2435_RS02830	COG1136	(ABC) transporter
I2435_RS02835	COG0383	alpha-mannosidase activity
I2435_RS02850	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I2435_RS02850	COG3291	Pkd domain containing protein
I2435_RS02855	COG2723	6-phospho-beta-galactosidase activity
I2435_RS02865	COG1940	carbohydrate kinase activity
I2435_RS02870	COG1175	transmembrane transport
I2435_RS02875	COG0395	ABC-type sugar transport system, permease component
I2435_RS02880	COG1653	transport
I2435_RS02890	COG2972	Histidine kinase
I2435_RS02895	COG2207	Transcriptional regulator
I2435_RS02895	COG4753	response regulator
I2435_RS02900	COG3250	beta-galactosidase activity
I2435_RS02920	COG1605	Chorismate mutase
I2435_RS02920	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I2435_RS02945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2435_RS02960	COG1376	ErfK ybiS ycfS ynhG family protein
I2435_RS02975	COG1028	Short-chain dehydrogenase reductase Sdr
I2435_RS02985	COG0673	inositol 2-dehydrogenase activity
I2435_RS03005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I2435_RS03085	COG0747	negative chemotaxis
I2435_RS03090	COG0601	transmembrane transport
I2435_RS03095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2435_RS03100	COG0444	Belongs to the ABC transporter superfamily
I2435_RS03135	COG1702	phosphate starvation-inducible protein PhoH
I2435_RS03140	COG1573	uracil-dna glycosylase
I2435_RS03155	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I2435_RS03170	COG0583	DNA-binding transcription factor activity
I2435_RS03175	COG0183	Belongs to the thiolase family
I2435_RS03180	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I2435_RS03190	COG1028	Short-chain dehydrogenase reductase Sdr
I2435_RS03195	COG2610	gluconate transmembrane transporter activity
I2435_RS03205	COG1940	carbohydrate kinase activity
I2435_RS03215	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2435_RS03220	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2435_RS03225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2435_RS03230	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2435_RS03270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2435_RS03280	COG0557	exoribonuclease II activity
I2435_RS03290	COG0463	Glycosyl transferase, family 2
I2435_RS03295	COG0778	Nitroreductase
I2435_RS03305	COG2274	protein secretion by the type I secretion system
I2435_RS03310	COG0006	proline dipeptidase activity
I2435_RS03315	COG1609	Transcriptional regulator
I2435_RS03330	COG0438	transferase activity, transferring glycosyl groups
I2435_RS03335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I2435_RS03360	COG1131	(ABC) transporter
I2435_RS03375	COG4555	ABC transporter
I2435_RS03400	COG0183	Belongs to the thiolase family
I2435_RS03415	COG0745	RESPONSE REGULATOR receiver
I2435_RS03420	COG5002	protein histidine kinase activity
I2435_RS03425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I2435_RS03445	COG0571	ribonuclease III activity
I2435_RS03450	COG1196	nuclear chromosome segregation
I2435_RS03505	COG1136	(ABC) transporter
I2435_RS03550	COG0318	PFAM AMP-dependent synthetase and ligase
I2435_RS03585	COG0561	phosphatase activity
I2435_RS03590	COG0561	phosphatase activity
I2435_RS03595	COG0552	protein localization to endoplasmic reticulum
I2435_RS03600	COG3711	transcriptional antiterminator
I2435_RS03605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2435_RS03605	COG1263	PTS System
I2435_RS03605	COG2190	(PTS) system
I2435_RS03615	COG3689	TIGRFAM TIGR03943 family protein
I2435_RS03620	COG0701	Predicted permease
I2435_RS03630	COG0745	RESPONSE REGULATOR receiver
I2435_RS03635	COG5002	protein histidine kinase activity
I2435_RS03640	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I2435_RS03645	COG0573	inorganic phosphate transmembrane transporter activity
I2435_RS03655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I2435_RS03670	COG2183	response to ionizing radiation
I2435_RS03715	COG0826	peptidase U32
I2435_RS03725	COG4443	Transcriptional Coactivator p15 (PC4)
I2435_RS03740	COG2814	Major facilitator Superfamily
I2435_RS03775	COG1518	maintenance of DNA repeat elements
I2435_RS03780	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I2435_RS03800	COG1191	sigma factor activity
I2435_RS03840	COG1078	dGTPase activity
I2435_RS03875	COG1609	Transcriptional regulator
I2435_RS03880	COG3716	PTS system mannose fructose sorbose family IID component
I2435_RS03885	COG3715	PTS system
I2435_RS03890	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2435_RS03905	COG1028	Short-chain dehydrogenase reductase Sdr
I2435_RS03915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2435_RS03920	COG0800	Aldolase
I2435_RS03925	COG5492	domain, Protein
I2435_RS03950	COG4868	Belongs to the UPF0371 family
I2435_RS03955	COG2814	Major facilitator Superfamily
I2435_RS03965	COG1187	pseudouridine synthase activity
I2435_RS03970	COG2309	aminopeptidase activity
I2435_RS03995	COG2723	6-phospho-beta-galactosidase activity
I2435_RS04005	COG3711	transcriptional antiterminator
I2435_RS04005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2435_RS04015	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2435_RS04025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2435_RS04035	COG1126	abc transporter atp-binding protein
I2435_RS04040	COG0765	amino acid transport
I2435_RS04060	COG1696	Membrane protein involved in D-alanine export
I2435_RS04070	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I2435_RS04075	COG0657	acetylesterase activity
I2435_RS04080	COG2182	Extracellular solute-binding protein
I2435_RS04085	COG0366	Alpha amylase catalytic
I2435_RS04095	COG1175	transmembrane transport
I2435_RS04100	COG3833	ABC-type maltose transport systems, permease component
I2435_RS04110	COG3833	ABC-type maltose transport systems, permease component
I2435_RS04115	COG1175	transmembrane transport
I2435_RS04125	COG1609	Transcriptional regulator
I2435_RS04130	COG1640	4-alpha-glucanotransferase
I2435_RS04135	COG0058	SHG alpha-glucan phosphorylase activity
I2435_RS04155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I2435_RS04160	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2435_RS04165	COG1234	tRNA 3'-trailer cleavage
I2435_RS04170	COG0300	oxidoreductase activity
I2435_RS04175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I2435_RS04175	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I2435_RS04195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I2435_RS04200	COG2384	SAM-dependent methyltransferase
I2435_RS04210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I2435_RS04215	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I2435_RS04225	COG1088	dTDP-glucose 4,6-dehydratase activity
I2435_RS04230	COG1051	belongs to the nudix hydrolase family
I2435_RS04235	COG0628	permease
I2435_RS04240	COG0457	Tetratricopeptide repeat
I2435_RS04245	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I2435_RS04260	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I2435_RS04275	COG0488	(ABC) transporter
I2435_RS04280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I2435_RS04285	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2435_RS04285	COG0022	dehydrogenase e1 component
I2435_RS04290	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2435_RS04300	COG0095	Lipoate-protein ligase
I2435_RS04305	COG3442	glutamine amidotransferase
I2435_RS04310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2435_RS04315	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I2435_RS04335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I2435_RS04345	COG0647	UMP catabolic process
I2435_RS04415	COG0481	GTPase activity
I2435_RS04440	COG3715	PTS system
I2435_RS04445	COG3716	PTS system mannose fructose sorbose family IID component
I2435_RS04450	COG2972	Histidine kinase
I2435_RS04455	COG4753	response regulator
I2435_RS04455	COG2207	Transcriptional regulator
I2435_RS04465	COG0322	excinuclease ABC activity
I2435_RS04475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2435_RS04530	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I2435_RS04550	COG0583	DNA-binding transcription factor activity
I2435_RS04560	COG0284	orotidine-5'-phosphate decarboxylase activity
I2435_RS04565	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I2435_RS04580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2435_RS04585	COG0765	amino acid transport
I2435_RS04610	COG0187	DNA topoisomerase II activity
I2435_RS04625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I2435_RS04645	COG0539	negative regulation of cytoplasmic translation
I2435_RS04695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I2435_RS04700	COG0583	DNA-binding transcription factor activity
I2435_RS04710	COG0564	pseudouridine synthase activity
I2435_RS04745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2435_RS04750	COG1136	(ABC) transporter
I2435_RS04755	COG0577	efflux transmembrane transporter activity
I2435_RS04780	COG1837	Belongs to the UPF0109 family
I2435_RS04795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I2435_RS04800	COG0336	Belongs to the RNA methyltransferase TrmD family
I2435_RS04820	COG1349	DNA-binding transcription factor activity
I2435_RS04825	COG1105	Belongs to the carbohydrate kinase PfkB family
I2435_RS04830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2435_RS04830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2435_RS04830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2435_RS04835	COG1388	LysM domain
I2435_RS04835	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2435_RS04870	COG1476	TRANSCRIPTIONal
I2435_RS04880	COG1388	LysM domain
I2435_RS04880	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2435_RS04900	COG0488	(ABC) transporter
I2435_RS04915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I2435_RS04920	COG0242	peptide deformylase activity
I2435_RS04925	COG0737	Belongs to the 5'-nucleotidase family
I2435_RS04930	COG1132	(ABC) transporter
I2435_RS04935	COG1132	(ABC) transporter
I2435_RS04965	COG3425	synthase
I2435_RS04975	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I2435_RS04990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I2435_RS05005	COG0105	UTP biosynthetic process
I2435_RS05025	COG0083	homoserine kinase activity
I2435_RS05030	COG0285	dihydrofolate synthase activity
I2435_RS05035	COG0302	gtp cyclohydrolase
I2435_RS05050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I2435_RS05055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I2435_RS05065	COG1176	ABC-type spermidine putrescine transport system, permease component I
I2435_RS05070	COG1177	transmembrane transport
I2435_RS05090	COG0628	permease
I2435_RS05100	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I2435_RS05115	COG1104	cysteine desulfurase activity
I2435_RS05130	COG2357	RelA SpoT domain protein
I2435_RS05140	COG0564	pseudouridine synthase activity
I2435_RS05145	COG0280	phosphate acetyltransferase
I2435_RS05150	COG4221	oxidoreductase activity
I2435_RS05165	COG1174	glycine betaine transport
I2435_RS05175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2435_RS05185	COG1942	4-Oxalocrotonate Tautomerase
I2435_RS05200	COG2890	protein-(glutamine-N5) methyltransferase activity
I2435_RS05205	COG0009	L-threonylcarbamoyladenylate synthase
I2435_RS05210	COG1247	-acetyltransferase
I2435_RS05215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I2435_RS05245	COG3764	Sortase (surface protein transpeptidase)
I2435_RS05250	COG0346	lactoylglutathione lyase activity
I2435_RS05255	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2435_RS05275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I2435_RS05285	COG2188	Transcriptional regulator
I2435_RS05310	COG1396	sequence-specific DNA binding
I2435_RS05320	COG4974	Belongs to the 'phage' integrase family
I2435_RS05325	COG5002	protein histidine kinase activity
I2435_RS05330	COG0745	RESPONSE REGULATOR receiver
I2435_RS05335	COG0577	efflux transmembrane transporter activity
I2435_RS05340	COG1136	(ABC) transporter
I2435_RS05370	COG3052	prosthetic group binding
I2435_RS05375	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I2435_RS05380	COG0511	ligase activity, forming carbon-carbon bonds
I2435_RS05390	COG2851	Citrate transporter
I2435_RS05410	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I2435_RS05415	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I2435_RS05430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2435_RS05435	COG0758	DNA mediated transformation
I2435_RS05445	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2435_RS05450	COG0577	efflux transmembrane transporter activity
I2435_RS05450	COG1136	(ABC) transporter
I2435_RS05485	COG1131	(ABC) transporter
I2435_RS05510	COG2226	methyltransferase
I2435_RS05520	COG1272	protein, Hemolysin III
I2435_RS05525	COG1597	lipid kinase activity
I2435_RS05535	COG0488	(ABC) transporter
I2435_RS05550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2435_RS05555	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I2435_RS05555	COG1328	CTP reductase activity
I2435_RS05560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I2435_RS05565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I2435_RS05585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I2435_RS05590	COG4684	Psort location CytoplasmicMembrane, score
I2435_RS05595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2435_RS05600	COG1079	Belongs to the binding-protein-dependent transport system permease family
I2435_RS05605	COG4603	Belongs to the binding-protein-dependent transport system permease family
I2435_RS05610	COG3845	ABC transporter
I2435_RS05615	COG1744	ABC transporter substrate-binding protein PnrA-like
I2435_RS05630	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I2435_RS05635	COG2813	Specifically methylates the guanine in position
I2435_RS05700	COG5002	protein histidine kinase activity
I2435_RS05705	COG0745	RESPONSE REGULATOR receiver
I2435_RS05715	COG0704	Plays a role in the regulation of phosphate uptake
I2435_RS05730	COG0581	inorganic phosphate transmembrane transporter activity
I2435_RS05735	COG0573	inorganic phosphate transmembrane transporter activity
I2435_RS05745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2435_RS05745	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I2435_RS05750	COG0483	inositol monophosphate 1-phosphatase activity
I2435_RS05765	COG0196	riboflavin kinase activity
I2435_RS05795	COG4591	ABC-type transport system involved in lipoprotein release permease component
I2435_RS05795	COG1136	(ABC) transporter
I2435_RS05845	COG1115	amino acid carrier protein
I2435_RS05850	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I2435_RS05855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2435_RS05860	COG1126	abc transporter atp-binding protein
I2435_RS05865	COG0765	amino acid transport
I2435_RS05870	COG2824	Alkylphosphonate utilization operon protein PhnA
I2435_RS05885	COG0469	pyruvate kinase activity
I2435_RS05900	COG1725	Transcriptional regulator
I2435_RS05905	COG1131	(ABC) transporter
I2435_RS05940	COG0301	tRNA thio-modification
I2435_RS05945	COG1104	cysteine desulfurase activity
I2435_RS05955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2435_RS05960	COG3679	Belongs to the UPF0342 family
I2435_RS05970	COG0710	3-dehydroquinate dehydratase activity
I2435_RS05975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I2435_RS05980	COG1368	sulfuric ester hydrolase activity
I2435_RS06030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2435_RS06035	COG1368	sulfuric ester hydrolase activity
I2435_RS06040	COG0297	glycogen (starch) synthase activity
I2435_RS06060	COG0463	Glycosyl transferase, family 2
I2435_RS06085	COG0463	Glycosyl transferase, family 2
I2435_RS06095	COG1091	dTDP-4-dehydrorhamnose reductase activity
I2435_RS06100	COG2151	metal-sulfur cluster biosynthetic enzyme
I2435_RS06105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I2435_RS06110	COG0358	DNA primase activity
I2435_RS06115	COG1970	mechanosensitive ion channel activity
I2435_RS06125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2435_RS06130	COG0436	Aminotransferase
I2435_RS06135	COG1074	ATP-dependent DNA helicase activity
I2435_RS06140	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I2435_RS06175	COG1595	DNA-templated transcription, initiation
I2435_RS06180	COG1523	belongs to the glycosyl hydrolase 13 family
I2435_RS06235	COG1309	transcriptional regulator
I2435_RS06250	COG0577	efflux transmembrane transporter activity
I2435_RS06330	COG0058	SHG alpha-glucan phosphorylase activity
I2435_RS06340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2435_RS06345	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2435_RS06350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I2435_RS06355	COG1523	belongs to the glycosyl hydrolase 13 family
I2435_RS06360	COG1597	lipid kinase activity
I2435_RS06370	COG4708	membrane
I2435_RS06450	COG0772	Belongs to the SEDS family
I2435_RS06455	COG1012	belongs to the aldehyde dehydrogenase family
I2435_RS06465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2435_RS06470	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I2435_RS06475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2435_RS06495	COG1476	TRANSCRIPTIONal
I2435_RS06520	COG0038	chloride channel
I2435_RS06530	COG0716	FMN binding
I2435_RS06535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I2435_RS06540	COG2153	protein acetylation
I2435_RS06545	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I2435_RS06560	COG3716	PTS system mannose fructose sorbose family IID component
I2435_RS06565	COG3715	PTS system
I2435_RS06570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2435_RS06570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2435_RS06580	COG2188	Transcriptional regulator
I2435_RS06585	COG3684	Belongs to the aldolase LacD family
I2435_RS06590	COG2222	sugar isomerase
I2435_RS06595	COG2188	Transcriptional regulator
I2435_RS06630	COG0017	Asparaginyl-tRNA synthetase
I2435_RS06635	COG0436	Aminotransferase
I2435_RS06645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2435_RS06645	COG1199	ATP-dependent helicase activity
I2435_RS06645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2435_RS06645	COG1199	ATP-dependent helicase activity
I2435_RS06655	COG2177	Part of the ABC transporter FtsEX involved in
I2435_RS06660	COG2884	Cell division ATP-binding protein ftsE
I2435_RS06675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I2435_RS06690	COG1131	(ABC) transporter
I2435_RS06715	COG1396	sequence-specific DNA binding
I2435_RS06720	COG0772	Belongs to the SEDS family
I2435_RS06730	COG1164	Oligoendopeptidase f
I2435_RS06735	COG0386	Belongs to the glutathione peroxidase family
I2435_RS06755	COG3859	Proton-coupled thiamine transporter YuaJ
I2435_RS06760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I2435_RS06770	COG0588	phosphoglycerate mutase activity
I2435_RS06780	COG1373	ATPase (AAA superfamily
I2435_RS06835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I2435_RS06840	COG1316	TRANSCRIPTIONal
I2435_RS06850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I2435_RS06860	COG0024	Methionine aminopeptidase
I2435_RS06865	COG4109	DRTGG domain
I2435_RS06870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2435_RS06890	COG1028	Short-chain dehydrogenase reductase Sdr
I2435_RS06905	COG0800	Aldolase
I2435_RS06910	COG2186	Transcriptional regulator
I2435_RS06915	COG3250	beta-galactosidase activity
I2435_RS06925	COG2211	Major facilitator Superfamily
I2435_RS06945	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I2435_RS06945	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I2435_RS06955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I2435_RS06960	COG1956	GAF domain-containing protein
I2435_RS06980	COG0513	Belongs to the DEAD box helicase family
I2435_RS06985	COG0726	polysaccharide deacetylase
I2435_RS07005	COG4122	O-methyltransferase activity
I2435_RS07010	COG0546	phosphoglycolate phosphatase activity
I2435_RS07035	COG1187	pseudouridine synthase activity
I2435_RS07040	COG0363	glucosamine-6-phosphate deaminase activity
I2435_RS07065	COG2333	competence protein COMEC
I2435_RS07065	COG0658	competence protein
I2435_RS07075	COG0204	Acyl-transferase
I2435_RS07080	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I2435_RS07090	COG3158	transport of potassium into the cell
I2435_RS07095	COG0513	Belongs to the DEAD box helicase family
I2435_RS07110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2435_RS07125	COG0768	penicillin binding
I2435_RS07130	COG2116	formate transmembrane transporter activity
I2435_RS07135	COG5433	transposase activity
I2435_RS07145	COG1827	regulation of RNA biosynthetic process
I2435_RS07155	COG0167	dihydroorotate dehydrogenase activity
I2435_RS07185	COG4698	Protein conserved in bacteria
I2435_RS07190	COG2755	lipolytic protein G-D-S-L family
I2435_RS07205	COG0497	DNA recombination
I2435_RS07210	COG1438	arginine binding
I2435_RS07215	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I2435_RS07235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I2435_RS07245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2435_RS07250	COG1126	abc transporter atp-binding protein
I2435_RS07255	COG0765	amino acid transport
I2435_RS07265	COG4703	Protein of unknown function (DUF1797)
I2435_RS07270	COG0542	response to heat
I2435_RS07275	COG0494	nUDIX hydrolase
I2435_RS07290	COG3599	regulation of cell shape
I2435_RS07310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I2435_RS07320	COG0849	cell division
I2435_RS07345	COG1217	gtp-binding protein TYPA
I2435_RS07350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I2435_RS07355	COG1940	carbohydrate kinase activity
I2435_RS07360	COG4483	Protein conserved in bacteria
I2435_RS07365	COG0783	Belongs to the Dps family
I2435_RS07375	COG4470	Protein conserved in bacteria
I2435_RS07385	COG3480	Lon protease (S16) C-terminal proteolytic domain
I2435_RS07390	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I2435_RS07395	COG0742	ribosomal rna small subunit methyltransferase
I2435_RS07405	COG0549	Belongs to the carbamate kinase family
I2435_RS07410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2435_RS07415	COG1288	antiporter activity
I2435_RS07425	COG0454	-acetyltransferase
I2435_RS07455	COG2315	Protein conserved in bacteria
I2435_RS07460	COG2972	Histidine kinase
I2435_RS07465	COG2207	Transcriptional regulator
I2435_RS07465	COG4753	response regulator
I2435_RS07475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2435_RS07480	COG0785	Cytochrome C biogenesis protein
I2435_RS07490	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I2435_RS07495	COG1518	maintenance of DNA repeat elements
I2435_RS07640	COG1114	Component of the transport system for branched-chain amino acids
I2435_RS07665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2435_RS07670	COG2274	protein secretion by the type I secretion system
I2435_RS07725	COG0708	Exodeoxyribonuclease III
I2435_RS07730	COG1393	Belongs to the ArsC family
I2435_RS07735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I2435_RS07775	COG1131	(ABC) transporter
I2435_RS07815	COG0751	glycine-tRNA ligase activity
I2435_RS07825	COG1755	Isoprenylcysteine carboxyl methyltransferase
I2435_RS07835	COG0656	L-ascorbic acid biosynthetic process
I2435_RS07845	COG1283	sodium-dependent phosphate transmembrane transporter activity
I2435_RS07855	COG1879	ABC-type sugar transport system periplasmic component
I2435_RS07860	COG1172	Belongs to the binding-protein-dependent transport system permease family
I2435_RS07870	COG1869	D-ribose catabolic process
I2435_RS07875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2435_RS07880	COG1609	Transcriptional regulator
I2435_RS07895	COG0561	phosphatase activity
I2435_RS07900	COG2860	membrane
I2435_RS07910	COG2723	6-phospho-beta-galactosidase activity
I2435_RS07915	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2435_RS07915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2435_RS07920	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2435_RS07925	COG3711	transcriptional antiterminator
I2435_RS07965	COG2217	Heavy metal translocating P-type atpase
I2435_RS07985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I2435_RS07995	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I2435_RS08000	COG0195	Participates in both transcription termination and antitermination
I2435_RS08025	COG4473	ABC transporter
I2435_RS08030	COG1131	(ABC) transporter
I2435_RS08040	COG0537	adenosine 5'-monophosphoramidase activity
I2435_RS08050	COG1316	TRANSCRIPTIONal
I2435_RS08060	COG0802	atpase or kinase
I2435_RS08065	COG2252	PERMEase
I2435_RS08070	COG0561	phosphatase activity
I2435_RS08080	COG3715	PTS system
I2435_RS08085	COG3716	PTS system mannose fructose sorbose family IID component
I2435_RS08110	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I2435_RS08115	COG0439	Biotin carboxylase
I2435_RS08130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2435_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
I2435_RS08140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I2435_RS08145	COG2070	2-Nitropropane dioxygenase
I2435_RS08155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I2435_RS08165	COG1024	Enoyl-CoA hydratase
I2435_RS08170	COG0484	heat shock protein binding
I2435_RS08185	COG1420	regulation of RNA biosynthetic process
I2435_RS08195	COG1876	peptidase activity
I2435_RS08200	COG0588	phosphoglycerate mutase activity
I2435_RS08205	COG2848	UPF0210 protein
I2435_RS08210	COG3830	Belongs to the UPF0237 family
I2435_RS08220	COG2261	transglycosylase associated protein
I2435_RS08225	COG0697	spore germination
I2435_RS08230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I2435_RS08245	COG1335	isochorismatase
I2435_RS08250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I2435_RS08255	COG0436	Aminotransferase
I2435_RS08265	COG0561	phosphatase activity
I2435_RS08270	COG0252	asparaginase activity
I2435_RS08275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I2435_RS08280	COG1129	ABC transporter
I2435_RS08295	COG1132	(ABC) transporter
I2435_RS08300	COG4988	ABC transporter
I2435_RS08305	COG1120	ATPase activity
I2435_RS08330	COG1388	LysM domain
I2435_RS08330	COG3942	CHAP domain
I2435_RS08345	COG0653	protein targeting
I2435_RS08350	COG1482	cell wall glycoprotein biosynthetic process
I2435_RS08355	COG1940	carbohydrate kinase activity
I2435_RS08365	COG2190	(PTS) system
I2435_RS08365	COG1263	PTS System
I2435_RS08365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2435_RS08370	COG1621	beta-fructofuranosidase activity
I2435_RS08375	COG1609	Transcriptional regulator
I2435_RS08400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2435_RS08415	COG2131	deaminase
I2435_RS08420	COG0006	proline dipeptidase activity
I2435_RS08460	COG1194	a g-specific adenine glycosylase
I2435_RS08475	COG3118	belongs to the thioredoxin family
I2435_RS08480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2435_RS08490	COG1286	toxin biosynthetic process
I2435_RS08505	COG0681	Belongs to the peptidase S26 family
I2435_RS08510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I2435_RS08525	COG1882	Formate acetyltransferase
I2435_RS08535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2435_RS08545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2435_RS08555	COG2814	Major facilitator Superfamily
I2435_RS08560	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2435_RS08565	COG2936	dipeptidyl-peptidase activity
I2435_RS08600	COG5002	protein histidine kinase activity
I2435_RS08620	COG0789	Transcriptional regulator
I2435_RS08635	COG2081	HI0933 family
I2435_RS08660	COG1214	PFAM Peptidase M22, glycoprotease
I2435_RS08675	COG4608	Belongs to the ABC transporter superfamily
I2435_RS08680	COG0444	Belongs to the ABC transporter superfamily
I2435_RS08685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2435_RS08690	COG0601	transmembrane transport
I2435_RS08695	COG4166	transmembrane transport
I2435_RS08700	COG0174	glutamine synthetase
I2435_RS08705	COG0789	Transcriptional regulator
I2435_RS08715	COG0126	phosphoglycerate kinase activity
I2435_RS08720	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I2435_RS08750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2435_RS08765	COG1564	THIamine pyrophosphokinase
I2435_RS08790	COG0084	hydrolase, TatD family'
I2435_RS08795	COG1737	Transcriptional regulator
I2435_RS08800	COG3458	cephalosporin-C deacetylase activity
I2435_RS08810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2435_RS08820	COG2731	YhcH YjgK YiaL family protein
I2435_RS08825	COG0395	ABC-type sugar transport system, permease component
I2435_RS08830	COG1175	transmembrane transport
I2435_RS08860	COG0191	fructose-bisphosphate aldolase activity
I2435_RS08885	COG0544	peptidyl-prolyl cis-trans isomerase activity
I2435_RS08890	COG0366	Alpha amylase catalytic
I2435_RS08895	COG0668	transmembrane transport
I2435_RS08905	COG4720	Psort location CytoplasmicMembrane, score
I2435_RS08910	COG0352	thiamine-phosphate diphosphorylase activity
I2435_RS08910	COG0351	phosphomethylpyrimidine kinase
I2435_RS08915	COG0101	tRNA pseudouridine synthase activity
I2435_RS08920	COG0527	aspartate kinase activity
I2435_RS08970	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2435_RS08980	COG1597	lipid kinase activity
I2435_RS08985	COG1609	Transcriptional regulator
I2435_RS08990	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I2435_RS08995	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2435_RS09000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2435_RS09005	COG2017	converts alpha-aldose to the beta-anomer
I2435_RS09050	COG4974	Belongs to the 'phage' integrase family
I2435_RS09105	COG0582	viral genome integration into host DNA
I2435_RS09110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I2435_RS09115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I2435_RS09130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2435_RS09140	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I2435_RS09150	COG1045	serine acetyltransferase
I2435_RS09160	COG1185	polyribonucleotide nucleotidyltransferase activity
I2435_RS09180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I2435_RS09185	COG1846	Transcriptional regulator
I2435_RS09200	COG0442	prolyl-tRNA aminoacylation
I2435_RS09210	COG4589	Belongs to the CDS family
I2435_RS09220	COG1862	Preprotein translocase
I2435_RS09235	COG3842	ATPase activity
I2435_RS09280	COG1263	PTS System
I2435_RS09280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2435_RS09280	COG2190	(PTS) system
I2435_RS09290	COG2723	6-phospho-beta-galactosidase activity
I2435_RS09295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2435_RS09295	COG1263	PTS System
I2435_RS09295	COG2190	(PTS) system
I2435_RS09300	COG3711	transcriptional antiterminator
I2435_RS09305	COG1609	Transcriptional regulator
I2435_RS09310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I2435_RS09340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I2435_RS09345	COG0512	Glutamine amidotransferase of anthranilate synthase
I2435_RS09350	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I2435_RS09385	COG1132	(ABC) transporter
I2435_RS09430	COG1882	Formate acetyltransferase
I2435_RS09435	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2435_RS09440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2435_RS09445	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2435_RS09450	COG2390	Transcriptional regulator
I2435_RS09455	COG1349	DNA-binding transcription factor activity
I2435_RS09460	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2435_RS09525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I2435_RS09530	COG1428	Deoxynucleoside kinase
I2435_RS09545	COG4120	Belongs to the binding-protein-dependent transport system permease family
I2435_RS09570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2435_RS09575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2435_RS09585	COG1363	Peptidase, m42
I2435_RS09590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I2435_RS09620	COG0602	queuosine metabolic process
I2435_RS09640	COG1328	CTP reductase activity
I2435_RS09655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I2435_RS09665	COG1393	Belongs to the ArsC family
I2435_RS09675	COG1058	Belongs to the CinA family
I2435_RS09675	COG1546	Belongs to the CinA family
I2435_RS09695	COG0519	Catalyzes the synthesis of GMP from XMP
I2435_RS09700	COG0632	four-way junction helicase activity
I2435_RS09705	COG2814	Major facilitator Superfamily
I2435_RS09725	COG1438	arginine binding
I2435_RS09730	COG0018	arginyl-trna synthetase
I2435_RS09735	COG0488	(ABC) transporter
I2435_RS09740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2435_RS09745	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2435_RS09750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2435_RS09770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I2435_RS09775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2435_RS09800	COG0494	nUDIX hydrolase
I2435_RS09820	COG1511	domain protein
I2435_RS09860	COG1484	DNA-dependent DNA replication
I2435_RS09915	COG0305	Participates in initiation and elongation during chromosome replication
I2435_RS09935	COG2816	NAD+ diphosphatase activity
I2435_RS09945	COG1760	l-serine dehydratase
I2435_RS09950	COG1760	l-serine dehydratase
I2435_RS09980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I2435_RS09990	COG0612	Peptidase, M16
I2435_RS10000	COG2501	S4 domain
I2435_RS10035	COG0517	IMP dehydrogenase activity
I2435_RS10035	COG0516	GMP reductase activity
I2435_RS10045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2435_RS10050	COG0488	(ABC) transporter
I2435_RS10080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I2435_RS10085	COG1475	DNA binding