locus-tag	class	description
I2436_RS00010	COG0592	DNA-directed DNA polymerase activity
I2436_RS00025	COG0012	GTP binding
I2436_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I2436_RS00040	COG2244	polysaccharide biosynthetic process
I2436_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I2436_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2436_RS00075	COG0531	amino acid
I2436_RS00195	COG3942	CHAP domain
I2436_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2436_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I2436_RS00255	COG0151	Belongs to the GarS family
I2436_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I2436_RS00275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2436_RS00295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I2436_RS00310	COG1012	belongs to the aldehyde dehydrogenase family
I2436_RS00310	COG1454	alcohol dehydrogenase
I2436_RS00315	COG1063	alcohol dehydrogenase
I2436_RS00320	COG1064	alcohol dehydrogenase
I2436_RS00325	COG1132	(ABC) transporter
I2436_RS00330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I2436_RS00340	COG1396	sequence-specific DNA binding
I2436_RS00350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I2436_RS00360	COG0051	transcription antitermination factor activity, RNA binding
I2436_RS00375	COG0089	rRNA binding
I2436_RS00465	COG0201	protein transport
I2436_RS00470	COG0563	adenylate kinase activity
I2436_RS00500	COG0203	ribosomal protein L17
I2436_RS00625	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I2436_RS00640	COG1121	(ABC) transporter
I2436_RS00645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2436_RS00655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2436_RS00655	COG4499	WXG100 protein secretion system (Wss), protein YukC
I2436_RS00665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I2436_RS00695	COG1136	(ABC) transporter
I2436_RS00700	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I2436_RS00705	COG1459	type II secretion system
I2436_RS00710	COG4537	Required for transformation and DNA binding
I2436_RS00750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2436_RS00765	COG3959	Transketolase, thiamine diphosphate binding domain
I2436_RS00770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I2436_RS00775	COG3590	peptidase
I2436_RS00780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I2436_RS00795	COG0450	alkyl hydroperoxide reductase
I2436_RS00825	COG4463	regulation of RNA biosynthetic process
I2436_RS00870	COG1051	belongs to the nudix hydrolase family
I2436_RS00890	COG1116	anion transmembrane transporter activity
I2436_RS00910	COG0564	pseudouridine synthase activity
I2436_RS00930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2436_RS00965	COG0495	leucyl-tRNA aminoacylation
I2436_RS00975	COG3037	sugar-specific permease SgaT UlaA
I2436_RS00995	COG3623	hexulose-6-phosphate isomerase
I2436_RS01020	COG4175	Glycine betaine
I2436_RS01020	COG3448	diguanylate cyclase activity
I2436_RS01030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2436_RS01030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2436_RS01035	COG1832	CoA-binding protein
I2436_RS01085	COG1268	BioY protein
I2436_RS01090	COG1234	tRNA 3'-trailer cleavage
I2436_RS01115	COG1215	transferase activity, transferring glycosyl groups
I2436_RS01145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2436_RS01145	COG3711	transcriptional antiterminator
I2436_RS01155	COG3730	PTS system glucitol sorbitol-specific
I2436_RS01160	COG3732	PTS system glucitol sorbitol-specific
I2436_RS01190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I2436_RS01195	COG0457	Tetratricopeptide repeat
I2436_RS01195	COG0705	Rhomboid family
I2436_RS01215	COG1132	(ABC) transporter
I2436_RS01220	COG1132	(ABC) transporter
I2436_RS01230	COG0756	dUTP diphosphatase activity
I2436_RS01285	COG1847	R3H domain protein
I2436_RS01330	COG2190	(PTS) system
I2436_RS01330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2436_RS01330	COG1263	PTS System
I2436_RS01335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2436_RS01335	COG2190	(PTS) system
I2436_RS01335	COG1263	PTS System
I2436_RS01360	COG1175	transmembrane transport
I2436_RS01365	COG0395	ABC-type sugar transport system, permease component
I2436_RS01370	COG2731	YhcH YjgK YiaL family protein
I2436_RS01380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2436_RS01390	COG3458	cephalosporin-C deacetylase activity
I2436_RS01395	COG1737	Transcriptional regulator
I2436_RS01400	COG0084	hydrolase, TatD family'
I2436_RS01430	COG1564	THIamine pyrophosphokinase
I2436_RS01445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2436_RS01475	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I2436_RS01490	COG0789	Transcriptional regulator
I2436_RS01495	COG0174	glutamine synthetase
I2436_RS01500	COG4166	transmembrane transport
I2436_RS01505	COG0601	transmembrane transport
I2436_RS01510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2436_RS01515	COG0444	Belongs to the ABC transporter superfamily
I2436_RS01520	COG4608	Belongs to the ABC transporter superfamily
I2436_RS01535	COG1214	PFAM Peptidase M22, glycoprotease
I2436_RS01550	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I2436_RS01560	COG2081	HI0933 family
I2436_RS01575	COG0789	Transcriptional regulator
I2436_RS01595	COG5002	protein histidine kinase activity
I2436_RS01630	COG2936	dipeptidyl-peptidase activity
I2436_RS01635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2436_RS01640	COG2814	Major facilitator Superfamily
I2436_RS01650	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2436_RS01660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2436_RS01675	COG1882	Formate acetyltransferase
I2436_RS01690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I2436_RS01695	COG0681	Belongs to the peptidase S26 family
I2436_RS01710	COG1286	toxin biosynthetic process
I2436_RS01720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2436_RS01725	COG3118	belongs to the thioredoxin family
I2436_RS01735	COG1194	a g-specific adenine glycosylase
I2436_RS01775	COG0006	proline dipeptidase activity
I2436_RS01780	COG2131	deaminase
I2436_RS01795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2436_RS01820	COG1609	Transcriptional regulator
I2436_RS01825	COG1621	beta-fructofuranosidase activity
I2436_RS01830	COG2190	(PTS) system
I2436_RS01830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2436_RS01830	COG1263	PTS System
I2436_RS01840	COG1940	carbohydrate kinase activity
I2436_RS01845	COG1482	cell wall glycoprotein biosynthetic process
I2436_RS01855	COG0653	protein targeting
I2436_RS01865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I2436_RS01870	COG1388	LysM domain
I2436_RS01870	COG3942	CHAP domain
I2436_RS01895	COG1120	ATPase activity
I2436_RS01900	COG4988	ABC transporter
I2436_RS01905	COG1132	(ABC) transporter
I2436_RS01920	COG1129	ABC transporter
I2436_RS01925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I2436_RS01930	COG0252	asparaginase activity
I2436_RS01935	COG0561	phosphatase activity
I2436_RS01945	COG0436	Aminotransferase
I2436_RS01950	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I2436_RS01955	COG1335	isochorismatase
I2436_RS01975	COG0697	spore germination
I2436_RS01980	COG2261	transglycosylase associated protein
I2436_RS02000	COG3830	Belongs to the UPF0237 family
I2436_RS02005	COG2848	UPF0210 protein
I2436_RS02010	COG0588	phosphoglycerate mutase activity
I2436_RS02015	COG1876	peptidase activity
I2436_RS02025	COG1420	regulation of RNA biosynthetic process
I2436_RS02045	COG1024	Enoyl-CoA hydratase
I2436_RS02055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I2436_RS02065	COG2070	2-Nitropropane dioxygenase
I2436_RS02070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I2436_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
I2436_RS02080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2436_RS02095	COG0439	Biotin carboxylase
I2436_RS02110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I2436_RS02125	COG3716	PTS system mannose fructose sorbose family IID component
I2436_RS02130	COG3715	PTS system
I2436_RS02140	COG0561	phosphatase activity
I2436_RS02145	COG2252	PERMEase
I2436_RS02150	COG0802	atpase or kinase
I2436_RS02160	COG1316	TRANSCRIPTIONal
I2436_RS02170	COG0537	adenosine 5'-monophosphoramidase activity
I2436_RS02180	COG1131	(ABC) transporter
I2436_RS02185	COG4473	ABC transporter
I2436_RS02195	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I2436_RS02215	COG0195	Participates in both transcription termination and antitermination
I2436_RS02220	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I2436_RS02250	COG2217	Heavy metal translocating P-type atpase
I2436_RS02270	COG0698	ribose 5-phosphate isomerase
I2436_RS02290	COG3711	transcriptional antiterminator
I2436_RS02295	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2436_RS02300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2436_RS02300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2436_RS02305	COG2723	6-phospho-beta-galactosidase activity
I2436_RS02315	COG2860	membrane
I2436_RS02320	COG0561	phosphatase activity
I2436_RS02340	COG1283	sodium-dependent phosphate transmembrane transporter activity
I2436_RS02350	COG0656	L-ascorbic acid biosynthetic process
I2436_RS02375	COG1755	Isoprenylcysteine carboxyl methyltransferase
I2436_RS02425	COG1131	(ABC) transporter
I2436_RS02460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I2436_RS02465	COG1393	Belongs to the ArsC family
I2436_RS02470	COG0708	Exodeoxyribonuclease III
I2436_RS02525	COG2274	protein secretion by the type I secretion system
I2436_RS02530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2436_RS02555	COG1114	Component of the transport system for branched-chain amino acids
I2436_RS02710	COG1518	maintenance of DNA repeat elements
I2436_RS02715	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I2436_RS02725	COG0785	Cytochrome C biogenesis protein
I2436_RS02730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2436_RS02740	COG2207	Transcriptional regulator
I2436_RS02740	COG4753	response regulator
I2436_RS02745	COG2972	Histidine kinase
I2436_RS02750	COG2315	Protein conserved in bacteria
I2436_RS02775	COG2235	arginine
I2436_RS02780	COG0454	-acetyltransferase
I2436_RS02790	COG1288	antiporter activity
I2436_RS02795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2436_RS02800	COG0549	Belongs to the carbamate kinase family
I2436_RS02810	COG0742	ribosomal rna small subunit methyltransferase
I2436_RS02815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I2436_RS02820	COG3480	Lon protease (S16) C-terminal proteolytic domain
I2436_RS02825	COG4470	Protein conserved in bacteria
I2436_RS02830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I2436_RS02835	COG1131	(ABC) transporter
I2436_RS02840	COG0842	Transport permease protein
I2436_RS02845	COG4585	Histidine kinase
I2436_RS02850	COG2197	response regulator
I2436_RS02860	COG0783	Belongs to the Dps family
I2436_RS02865	COG4483	Protein conserved in bacteria
I2436_RS02870	COG1940	carbohydrate kinase activity
I2436_RS02875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I2436_RS02880	COG1217	gtp-binding protein TYPA
I2436_RS02905	COG0849	cell division
I2436_RS02915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I2436_RS02935	COG3599	regulation of cell shape
I2436_RS02950	COG0494	nUDIX hydrolase
I2436_RS02955	COG0542	response to heat
I2436_RS02960	COG4703	Protein of unknown function (DUF1797)
I2436_RS02970	COG0765	amino acid transport
I2436_RS02975	COG1126	abc transporter atp-binding protein
I2436_RS02980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2436_RS02985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I2436_RS02990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I2436_RS03010	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I2436_RS03015	COG1438	arginine binding
I2436_RS03020	COG0497	DNA recombination
I2436_RS03035	COG2755	lipolytic protein G-D-S-L family
I2436_RS03040	COG4698	Protein conserved in bacteria
I2436_RS03060	COG1396	sequence-specific DNA binding
I2436_RS03070	COG0167	dihydroorotate dehydrogenase activity
I2436_RS03080	COG1827	regulation of RNA biosynthetic process
I2436_RS03090	COG2116	formate transmembrane transporter activity
I2436_RS03095	COG0768	penicillin binding
I2436_RS03110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2436_RS03125	COG0513	Belongs to the DEAD box helicase family
I2436_RS03140	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I2436_RS03145	COG0204	Acyl-transferase
I2436_RS03155	COG2333	competence protein COMEC
I2436_RS03155	COG0658	competence protein
I2436_RS03185	COG1187	pseudouridine synthase activity
I2436_RS03210	COG0546	phosphoglycolate phosphatase activity
I2436_RS03215	COG4122	O-methyltransferase activity
I2436_RS03230	COG0726	polysaccharide deacetylase
I2436_RS03235	COG0513	Belongs to the DEAD box helicase family
I2436_RS03255	COG1956	GAF domain-containing protein
I2436_RS03260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I2436_RS03270	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I2436_RS03270	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I2436_RS03295	COG2211	Major facilitator Superfamily
I2436_RS03305	COG3250	beta-galactosidase activity
I2436_RS03310	COG2186	Transcriptional regulator
I2436_RS03315	COG0800	Aldolase
I2436_RS03330	COG1028	Short-chain dehydrogenase reductase Sdr
I2436_RS03355	COG4109	DRTGG domain
I2436_RS03360	COG0024	Methionine aminopeptidase
I2436_RS03370	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I2436_RS03380	COG1316	TRANSCRIPTIONal
I2436_RS03385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I2436_RS03465	COG0551	DNA topoisomerase type I activity
I2436_RS03465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2436_RS03490	COG2274	protein secretion by the type I secretion system
I2436_RS03500	COG3290	protein histidine kinase activity
I2436_RS03550	COG2378	regulation of single-species biofilm formation
I2436_RS03585	COG0588	phosphoglycerate mutase activity
I2436_RS03595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I2436_RS03600	COG3859	Proton-coupled thiamine transporter YuaJ
I2436_RS03620	COG0386	Belongs to the glutathione peroxidase family
I2436_RS03625	COG1164	Oligoendopeptidase f
I2436_RS03635	COG0772	Belongs to the SEDS family
I2436_RS03640	COG1396	sequence-specific DNA binding
I2436_RS03650	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I2436_RS03665	COG2884	Cell division ATP-binding protein ftsE
I2436_RS03670	COG2177	Part of the ABC transporter FtsEX involved in
I2436_RS03680	COG1199	ATP-dependent helicase activity
I2436_RS03680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2436_RS03680	COG1199	ATP-dependent helicase activity
I2436_RS03680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2436_RS03690	COG0436	Aminotransferase
I2436_RS03695	COG0017	Asparaginyl-tRNA synthetase
I2436_RS03705	COG1660	Displays ATPase and GTPase activities
I2436_RS03730	COG2188	Transcriptional regulator
I2436_RS03735	COG2222	sugar isomerase
I2436_RS03740	COG3684	Belongs to the aldolase LacD family
I2436_RS03745	COG2188	Transcriptional regulator
I2436_RS03755	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2436_RS03755	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2436_RS03760	COG3715	PTS system
I2436_RS03765	COG3716	PTS system mannose fructose sorbose family IID component
I2436_RS03780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I2436_RS03785	COG2153	protein acetylation
I2436_RS03795	COG0716	FMN binding
I2436_RS03805	COG0038	chloride channel
I2436_RS03825	COG1476	TRANSCRIPTIONal
I2436_RS03845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2436_RS03850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I2436_RS03855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2436_RS03865	COG1012	belongs to the aldehyde dehydrogenase family
I2436_RS03870	COG0772	Belongs to the SEDS family
I2436_RS03940	COG4708	membrane
I2436_RS03950	COG1597	lipid kinase activity
I2436_RS03955	COG1523	belongs to the glycosyl hydrolase 13 family
I2436_RS03960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I2436_RS03965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2436_RS03970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2436_RS03980	COG0058	SHG alpha-glucan phosphorylase activity
I2436_RS04020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I2436_RS04060	COG0577	efflux transmembrane transporter activity
I2436_RS04075	COG1309	transcriptional regulator
I2436_RS04125	COG1523	belongs to the glycosyl hydrolase 13 family
I2436_RS04130	COG1595	DNA-templated transcription, initiation
I2436_RS04175	COG0436	Aminotransferase
I2436_RS04180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2436_RS04190	COG1970	mechanosensitive ion channel activity
I2436_RS04195	COG0358	DNA primase activity
I2436_RS04200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I2436_RS04205	COG2151	metal-sulfur cluster biosynthetic enzyme
I2436_RS04210	COG1091	dTDP-4-dehydrorhamnose reductase activity
I2436_RS04220	COG0463	Glycosyl transferase, family 2
I2436_RS04245	COG0463	Glycosyl transferase, family 2
I2436_RS04265	COG0297	glycogen (starch) synthase activity
I2436_RS04270	COG1368	sulfuric ester hydrolase activity
I2436_RS04275	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2436_RS04325	COG1368	sulfuric ester hydrolase activity
I2436_RS04330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I2436_RS04335	COG0710	3-dehydroquinate dehydratase activity
I2436_RS04350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2436_RS04360	COG1104	cysteine desulfurase activity
I2436_RS04400	COG1131	(ABC) transporter
I2436_RS04405	COG1725	Transcriptional regulator
I2436_RS04420	COG0469	pyruvate kinase activity
I2436_RS04435	COG2824	Alkylphosphonate utilization operon protein PhnA
I2436_RS04440	COG0765	amino acid transport
I2436_RS04445	COG1126	abc transporter atp-binding protein
I2436_RS04450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2436_RS04455	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I2436_RS04460	COG1115	amino acid carrier protein
I2436_RS04510	COG1136	(ABC) transporter
I2436_RS04510	COG4591	ABC-type transport system involved in lipoprotein release permease component
I2436_RS04540	COG0196	riboflavin kinase activity
I2436_RS04555	COG0483	inositol monophosphate 1-phosphatase activity
I2436_RS04560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2436_RS04560	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I2436_RS04570	COG0573	inorganic phosphate transmembrane transporter activity
I2436_RS04575	COG0581	inorganic phosphate transmembrane transporter activity
I2436_RS04590	COG0704	Plays a role in the regulation of phosphate uptake
I2436_RS04600	COG0745	RESPONSE REGULATOR receiver
I2436_RS04605	COG5002	protein histidine kinase activity
I2436_RS04695	COG1072	(Pantothenic acid kinase))
I2436_RS04700	COG2813	Specifically methylates the guanine in position
I2436_RS04705	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I2436_RS04720	COG1744	ABC transporter substrate-binding protein PnrA-like
I2436_RS04725	COG3845	ABC transporter
I2436_RS04730	COG4603	Belongs to the binding-protein-dependent transport system permease family
I2436_RS04735	COG1079	Belongs to the binding-protein-dependent transport system permease family
I2436_RS04740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2436_RS04750	COG4684	Psort location CytoplasmicMembrane, score
I2436_RS04755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I2436_RS04765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I2436_RS04775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I2436_RS04780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I2436_RS04785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I2436_RS04785	COG1328	CTP reductase activity
I2436_RS04790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2436_RS04805	COG0488	(ABC) transporter
I2436_RS04815	COG1597	lipid kinase activity
I2436_RS04820	COG1272	protein, Hemolysin III
I2436_RS04830	COG2226	methyltransferase
I2436_RS04855	COG1131	(ABC) transporter
I2436_RS04885	COG0577	efflux transmembrane transporter activity
I2436_RS04885	COG1136	(ABC) transporter
I2436_RS04890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2436_RS04900	COG0758	DNA mediated transformation
I2436_RS04905	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2436_RS04920	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I2436_RS04925	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I2436_RS04945	COG2851	Citrate transporter
I2436_RS04955	COG0511	ligase activity, forming carbon-carbon bonds
I2436_RS04960	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I2436_RS05000	COG1136	(ABC) transporter
I2436_RS05005	COG0577	efflux transmembrane transporter activity
I2436_RS05010	COG0745	RESPONSE REGULATOR receiver
I2436_RS05015	COG5002	protein histidine kinase activity
I2436_RS05020	COG4974	Belongs to the 'phage' integrase family
I2436_RS05030	COG1396	sequence-specific DNA binding
I2436_RS05085	COG3843	relaxase mobilization nuclease domain protein
I2436_RS05130	COG2188	Transcriptional regulator
I2436_RS05145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I2436_RS05165	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2436_RS05170	COG0346	lactoylglutathione lyase activity
I2436_RS05175	COG3764	Sortase (surface protein transpeptidase)
I2436_RS05210	COG1247	-acetyltransferase
I2436_RS05215	COG0009	L-threonylcarbamoyladenylate synthase
I2436_RS05220	COG2890	protein-(glutamine-N5) methyltransferase activity
I2436_RS05235	COG1942	4-Oxalocrotonate Tautomerase
I2436_RS05245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2436_RS05250	COG0516	GMP reductase activity
I2436_RS05255	COG1174	glycine betaine transport
I2436_RS05270	COG4221	oxidoreductase activity
I2436_RS05275	COG0280	phosphate acetyltransferase
I2436_RS05280	COG0564	pseudouridine synthase activity
I2436_RS05290	COG2357	RelA SpoT domain protein
I2436_RS05305	COG1104	cysteine desulfurase activity
I2436_RS05320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I2436_RS05330	COG0628	permease
I2436_RS05350	COG1177	transmembrane transport
I2436_RS05355	COG1176	ABC-type spermidine putrescine transport system, permease component I
I2436_RS05370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I2436_RS05385	COG0302	gtp cyclohydrolase
I2436_RS05390	COG0285	dihydrofolate synthase activity
I2436_RS05395	COG0083	homoserine kinase activity
I2436_RS05415	COG0105	UTP biosynthetic process
I2436_RS05430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I2436_RS05435	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I2436_RS05445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I2436_RS05455	COG3425	synthase
I2436_RS05485	COG1132	(ABC) transporter
I2436_RS05490	COG1132	(ABC) transporter
I2436_RS05495	COG0737	Belongs to the 5'-nucleotidase family
I2436_RS05500	COG0242	peptide deformylase activity
I2436_RS05505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I2436_RS05510	COG1132	(ABC) transporter
I2436_RS05520	COG0488	(ABC) transporter
I2436_RS05540	COG1388	LysM domain
I2436_RS05540	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2436_RS05565	COG1476	TRANSCRIPTIONal
I2436_RS05570	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2436_RS05570	COG1388	LysM domain
I2436_RS05575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2436_RS05575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2436_RS05575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2436_RS05580	COG1105	Belongs to the carbohydrate kinase PfkB family
I2436_RS05585	COG1349	DNA-binding transcription factor activity
I2436_RS05605	COG0336	Belongs to the RNA methyltransferase TrmD family
I2436_RS05610	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I2436_RS05635	COG1837	Belongs to the UPF0109 family
I2436_RS05650	COG0577	efflux transmembrane transporter activity
I2436_RS05655	COG1136	(ABC) transporter
I2436_RS05660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2436_RS05695	COG0564	pseudouridine synthase activity
I2436_RS05705	COG0583	DNA-binding transcription factor activity
I2436_RS05710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I2436_RS05755	COG0539	negative regulation of cytoplasmic translation
I2436_RS05775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I2436_RS05790	COG0187	DNA topoisomerase II activity
I2436_RS05815	COG0765	amino acid transport
I2436_RS05820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2436_RS05835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I2436_RS05840	COG0284	orotidine-5'-phosphate decarboxylase activity
I2436_RS05850	COG0583	DNA-binding transcription factor activity
I2436_RS05870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I2436_RS05920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2436_RS05930	COG0322	excinuclease ABC activity
I2436_RS05940	COG2207	Transcriptional regulator
I2436_RS05940	COG4753	response regulator
I2436_RS05945	COG2972	Histidine kinase
I2436_RS05950	COG3716	PTS system mannose fructose sorbose family IID component
I2436_RS05955	COG3715	PTS system
I2436_RS05975	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I2436_RS06045	COG0647	UMP catabolic process
I2436_RS06055	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I2436_RS06075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I2436_RS06080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2436_RS06085	COG3442	glutamine amidotransferase
I2436_RS06090	COG0095	Lipoate-protein ligase
I2436_RS06100	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2436_RS06105	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2436_RS06105	COG0022	dehydrogenase e1 component
I2436_RS06110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I2436_RS06115	COG0488	(ABC) transporter
I2436_RS06145	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I2436_RS06150	COG0457	Tetratricopeptide repeat
I2436_RS06155	COG0628	permease
I2436_RS06160	COG1051	belongs to the nudix hydrolase family
I2436_RS06165	COG1088	dTDP-glucose 4,6-dehydratase activity
I2436_RS06175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I2436_RS06180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I2436_RS06190	COG2384	SAM-dependent methyltransferase
I2436_RS06195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I2436_RS06215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I2436_RS06215	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I2436_RS06220	COG0300	oxidoreductase activity
I2436_RS06225	COG1234	tRNA 3'-trailer cleavage
I2436_RS06230	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2436_RS06235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I2436_RS06255	COG0058	SHG alpha-glucan phosphorylase activity
I2436_RS06260	COG1640	4-alpha-glucanotransferase
I2436_RS06265	COG1609	Transcriptional regulator
I2436_RS06275	COG1175	transmembrane transport
I2436_RS06280	COG3833	ABC-type maltose transport systems, permease component
I2436_RS06290	COG3833	ABC-type maltose transport systems, permease component
I2436_RS06295	COG1175	transmembrane transport
I2436_RS06305	COG0366	Alpha amylase catalytic
I2436_RS06310	COG2182	Extracellular solute-binding protein
I2436_RS06315	COG0657	acetylesterase activity
I2436_RS06320	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I2436_RS06330	COG1696	Membrane protein involved in D-alanine export
I2436_RS06345	COG0556	nucleotide-excision repair
I2436_RS06350	COG0765	amino acid transport
I2436_RS06355	COG1126	abc transporter atp-binding protein
I2436_RS06360	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2436_RS06370	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2436_RS06380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2436_RS06380	COG3711	transcriptional antiterminator
I2436_RS06390	COG2723	6-phospho-beta-galactosidase activity
I2436_RS06415	COG2309	aminopeptidase activity
I2436_RS06420	COG1187	pseudouridine synthase activity
I2436_RS06430	COG2814	Major facilitator Superfamily
I2436_RS06450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I2436_RS06460	COG5492	domain, Protein
I2436_RS06465	COG0800	Aldolase
I2436_RS06470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2436_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
I2436_RS06495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2436_RS06500	COG3715	PTS system
I2436_RS06505	COG3716	PTS system mannose fructose sorbose family IID component
I2436_RS06510	COG1609	Transcriptional regulator
I2436_RS06545	COG1078	dGTPase activity
I2436_RS06585	COG1191	sigma factor activity
I2436_RS06600	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I2436_RS06605	COG1518	maintenance of DNA repeat elements
I2436_RS06670	COG2814	Major facilitator Superfamily
I2436_RS06685	COG4443	Transcriptional Coactivator p15 (PC4)
I2436_RS06695	COG0826	peptidase U32
I2436_RS06740	COG2183	response to ionizing radiation
I2436_RS06750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I2436_RS06760	COG0573	inorganic phosphate transmembrane transporter activity
I2436_RS06765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I2436_RS06770	COG5002	protein histidine kinase activity
I2436_RS06775	COG0745	RESPONSE REGULATOR receiver
I2436_RS06785	COG0701	Predicted permease
I2436_RS06790	COG3689	TIGRFAM TIGR03943 family protein
I2436_RS06800	COG1263	PTS System
I2436_RS06800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2436_RS06800	COG2190	(PTS) system
I2436_RS06805	COG3711	transcriptional antiterminator
I2436_RS06810	COG0552	protein localization to endoplasmic reticulum
I2436_RS06815	COG0561	phosphatase activity
I2436_RS06820	COG0561	phosphatase activity
I2436_RS06830	COG1136	(ABC) transporter
I2436_RS06865	COG1196	nuclear chromosome segregation
I2436_RS06870	COG0571	ribonuclease III activity
I2436_RS06880	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I2436_RS06885	COG5002	protein histidine kinase activity
I2436_RS06890	COG0745	RESPONSE REGULATOR receiver
I2436_RS06925	COG4555	ABC transporter
I2436_RS06930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I2436_RS06935	COG0438	transferase activity, transferring glycosyl groups
I2436_RS06950	COG1609	Transcriptional regulator
I2436_RS06955	COG0006	proline dipeptidase activity
I2436_RS06965	COG0463	Glycosyl transferase, family 2
I2436_RS06970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I2436_RS06975	COG0557	exoribonuclease II activity
I2436_RS06985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2436_RS07020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2436_RS07025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2436_RS07030	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2436_RS07035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2436_RS07045	COG1940	carbohydrate kinase activity
I2436_RS07060	COG2610	gluconate transmembrane transporter activity
I2436_RS07065	COG1028	Short-chain dehydrogenase reductase Sdr
I2436_RS07075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I2436_RS07080	COG0183	Belongs to the thiolase family
I2436_RS07085	COG0583	DNA-binding transcription factor activity
I2436_RS07100	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I2436_RS07115	COG1573	uracil-dna glycosylase
I2436_RS07120	COG1702	phosphate starvation-inducible protein PhoH
I2436_RS07160	COG0444	Belongs to the ABC transporter superfamily
I2436_RS07165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2436_RS07170	COG0601	transmembrane transport
I2436_RS07175	COG0747	negative chemotaxis
I2436_RS07240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I2436_RS07260	COG0673	inositol 2-dehydrogenase activity
I2436_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
I2436_RS07285	COG1376	ErfK ybiS ycfS ynhG family protein
I2436_RS07305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2436_RS07330	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I2436_RS07330	COG1605	Chorismate mutase
I2436_RS07335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I2436_RS07350	COG3250	beta-galactosidase activity
I2436_RS07355	COG4753	response regulator
I2436_RS07355	COG2207	Transcriptional regulator
I2436_RS07360	COG2972	Histidine kinase
I2436_RS07370	COG1653	transport
I2436_RS07375	COG0395	ABC-type sugar transport system, permease component
I2436_RS07380	COG1175	transmembrane transport
I2436_RS07385	COG1940	carbohydrate kinase activity
I2436_RS07395	COG2723	6-phospho-beta-galactosidase activity
I2436_RS07400	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I2436_RS07400	COG3291	Pkd domain containing protein
I2436_RS07415	COG0383	alpha-mannosidase activity
I2436_RS07420	COG0577	efflux transmembrane transporter activity
I2436_RS07420	COG1136	(ABC) transporter
I2436_RS07475	COG2274	protein secretion by the type I secretion system
I2436_RS07490	COG3290	protein histidine kinase activity
I2436_RS07520	COG2137	regulation of response to DNA damage stimulus
I2436_RS07600	COG1040	competence protein
I2436_RS07605	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I2436_RS07610	COG1739	Uncharacterized protein family UPF0029
I2436_RS07620	COG1098	S1 RNA binding domain
I2436_RS07630	COG2197	response regulator
I2436_RS07635	COG4585	Histidine kinase
I2436_RS07645	COG2815	serine threonine protein kinase
I2436_RS07645	COG0515	serine threonine protein kinase
I2436_RS07655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2436_RS07655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2436_RS07660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I2436_RS07665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I2436_RS07685	COG1854	S-ribosylhomocysteine lyase activity
I2436_RS07695	COG0116	Belongs to the methyltransferase superfamily
I2436_RS07720	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2436_RS07730	COG3579	cysteine-type endopeptidase activity
I2436_RS07740	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I2436_RS07745	COG1113	amino acid transport
I2436_RS07750	COG0492	ferredoxin-NADP+ reductase activity
I2436_RS07760	COG1126	abc transporter atp-binding protein
I2436_RS07770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2436_RS07780	COG0513	Belongs to the DEAD box helicase family
I2436_RS07790	COG0768	penicillin binding
I2436_RS07830	COG1131	(ABC) transporter
I2436_RS07885	COG1774	PSP1 C-terminal conserved region
I2436_RS07890	COG0470	DNA polymerase III
I2436_RS07920	COG2244	polysaccharide biosynthetic process
I2436_RS07930	COG1120	ATPase activity
I2436_RS07935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I2436_RS07940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2436_RS07945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2436_RS07965	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2436_RS07970	COG1253	flavin adenine dinucleotide binding
I2436_RS07975	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I2436_RS07980	COG3231	kanamycin kinase activity
I2436_RS07985	COG1242	4 iron, 4 sulfur cluster binding
I2436_RS07990	COG0671	phosphoesterase, PA-phosphatase related
I2436_RS07995	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I2436_RS08050	COG1187	pseudouridine synthase activity
I2436_RS08105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2436_RS08110	COG1254	Belongs to the acylphosphatase family
I2436_RS08125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I2436_RS08155	COG1484	DNA-dependent DNA replication
I2436_RS08170	COG5002	protein histidine kinase activity
I2436_RS08175	COG0745	RESPONSE REGULATOR receiver
I2436_RS08190	COG1704	LemA family
I2436_RS08200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I2436_RS08205	COG0569	domain protein
I2436_RS08215	COG1114	Component of the transport system for branched-chain amino acids
I2436_RS08230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2436_RS08235	COG1464	Belongs to the NlpA lipoprotein family
I2436_RS08240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2436_RS08250	COG0789	Transcriptional regulator
I2436_RS08260	COG2226	methyltransferase
I2436_RS08265	COG0799	negative regulation of ribosome biogenesis
I2436_RS08270	COG1713	HD superfamily hydrolase involved in NAD metabolism
I2436_RS08275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2436_RS08280	COG1534	Rna-binding protein
I2436_RS08285	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2436_RS08290	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I2436_RS08335	COG0444	Belongs to the ABC transporter superfamily
I2436_RS08340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2436_RS08345	COG0601	transmembrane transport
I2436_RS08350	COG4166	transmembrane transport
I2436_RS08355	COG1686	Belongs to the peptidase S11 family
I2436_RS08360	COG1686	Belongs to the peptidase S11 family
I2436_RS08370	COG0719	Fe-S assembly protein
I2436_RS08380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2436_RS08385	COG0719	Fe-S assembly protein
I2436_RS08395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2436_RS08405	COG1968	undecaprenyl-diphosphatase activity
I2436_RS08410	COG0765	amino acid transport
I2436_RS08415	COG1126	abc transporter atp-binding protein
I2436_RS08445	COG0191	fructose-bisphosphate aldolase activity
I2436_RS08460	COG0504	CTP synthase activity
I2436_RS08470	COG0544	peptidyl-prolyl cis-trans isomerase activity
I2436_RS08475	COG0366	Alpha amylase catalytic
I2436_RS08480	COG0668	transmembrane transport
I2436_RS08490	COG4720	Psort location CytoplasmicMembrane, score
I2436_RS08495	COG0352	thiamine-phosphate diphosphorylase activity
I2436_RS08495	COG0351	phosphomethylpyrimidine kinase
I2436_RS08505	COG0527	aspartate kinase activity
I2436_RS08615	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2436_RS08625	COG1597	lipid kinase activity
I2436_RS08630	COG1609	Transcriptional regulator
I2436_RS08635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I2436_RS08640	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2436_RS08645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2436_RS08650	COG2017	converts alpha-aldose to the beta-anomer
I2436_RS08660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I2436_RS08675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2436_RS08685	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I2436_RS08695	COG1045	serine acetyltransferase
I2436_RS08725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I2436_RS08730	COG1846	Transcriptional regulator
I2436_RS08745	COG0442	prolyl-tRNA aminoacylation
I2436_RS08755	COG4589	Belongs to the CDS family
I2436_RS08765	COG1862	Preprotein translocase
I2436_RS08780	COG3842	ATPase activity
I2436_RS08830	COG1263	PTS System
I2436_RS08830	COG2190	(PTS) system
I2436_RS08830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2436_RS08835	COG1609	Transcriptional regulator
I2436_RS08850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I2436_RS08855	COG2264	protein methyltransferase activity
I2436_RS08890	COG0512	Glutamine amidotransferase of anthranilate synthase
I2436_RS08895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I2436_RS08910	COG1396	sequence-specific DNA binding
I2436_RS08975	COG1882	Formate acetyltransferase
I2436_RS08980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2436_RS08985	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2436_RS08990	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2436_RS09000	COG1349	DNA-binding transcription factor activity
I2436_RS09005	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2436_RS09075	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I2436_RS09080	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I2436_RS09085	COG1428	Deoxynucleoside kinase
I2436_RS09100	COG4120	Belongs to the binding-protein-dependent transport system permease family
I2436_RS09125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2436_RS09130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2436_RS09140	COG1363	Peptidase, m42
I2436_RS09145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I2436_RS09175	COG0602	queuosine metabolic process
I2436_RS09195	COG1328	CTP reductase activity
I2436_RS09210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I2436_RS09220	COG1393	Belongs to the ArsC family
I2436_RS09230	COG1546	Belongs to the CinA family
I2436_RS09230	COG1058	Belongs to the CinA family
I2436_RS09250	COG0519	Catalyzes the synthesis of GMP from XMP
I2436_RS09255	COG0632	four-way junction helicase activity
I2436_RS09260	COG2814	Major facilitator Superfamily
I2436_RS09280	COG1438	arginine binding
I2436_RS09285	COG0018	arginyl-trna synthetase
I2436_RS09290	COG0488	(ABC) transporter
I2436_RS09295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2436_RS09300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2436_RS09305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2436_RS09310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I2436_RS09320	COG1131	(ABC) transporter
I2436_RS09340	COG0124	histidyl-tRNA synthetase
I2436_RS09350	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I2436_RS09355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2436_RS09380	COG2197	response regulator
I2436_RS09395	COG0577	efflux transmembrane transporter activity
I2436_RS09395	COG1136	(ABC) transporter
I2436_RS09415	COG0494	nUDIX hydrolase
I2436_RS09435	COG1511	domain protein
I2436_RS09455	COG0305	Participates in initiation and elongation during chromosome replication
I2436_RS09475	COG2816	NAD+ diphosphatase activity
I2436_RS09485	COG1760	l-serine dehydratase
I2436_RS09490	COG1760	l-serine dehydratase
I2436_RS09520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I2436_RS09530	COG0612	Peptidase, M16
I2436_RS09540	COG2501	S4 domain
I2436_RS09580	COG0516	GMP reductase activity
I2436_RS09580	COG0517	IMP dehydrogenase activity
I2436_RS09590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2436_RS09595	COG0488	(ABC) transporter
I2436_RS09625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I2436_RS09630	COG1475	DNA binding