locus-tag	class	description
I2437_RS00010	COG0592	DNA-directed DNA polymerase activity
I2437_RS00025	COG0012	GTP binding
I2437_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I2437_RS00040	COG2244	polysaccharide biosynthetic process
I2437_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I2437_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2437_RS00075	COG0531	amino acid
I2437_RS00195	COG3942	CHAP domain
I2437_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2437_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I2437_RS00255	COG0151	Belongs to the GarS family
I2437_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I2437_RS00275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2437_RS00290	COG2255	four-way junction helicase activity
I2437_RS00295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I2437_RS00310	COG1454	alcohol dehydrogenase
I2437_RS00310	COG1012	belongs to the aldehyde dehydrogenase family
I2437_RS00320	COG1064	alcohol dehydrogenase
I2437_RS00325	COG1132	(ABC) transporter
I2437_RS00330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I2437_RS00340	COG1396	sequence-specific DNA binding
I2437_RS00350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I2437_RS00360	COG0051	transcription antitermination factor activity, RNA binding
I2437_RS00370	COG0088	Forms part of the polypeptide exit tunnel
I2437_RS00375	COG0089	rRNA binding
I2437_RS00465	COG0201	protein transport
I2437_RS00500	COG0203	ribosomal protein L17
I2437_RS00610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I2437_RS00615	COG1363	Peptidase, m42
I2437_RS00625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2437_RS00630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2437_RS00655	COG4120	Belongs to the binding-protein-dependent transport system permease family
I2437_RS00670	COG1428	Deoxynucleoside kinase
I2437_RS00675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I2437_RS00680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I2437_RS00750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2437_RS00755	COG1349	DNA-binding transcription factor activity
I2437_RS00760	COG2390	Transcriptional regulator
I2437_RS00765	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2437_RS00770	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2437_RS00775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2437_RS00780	COG1882	Formate acetyltransferase
I2437_RS00860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I2437_RS00865	COG0512	Glutamine amidotransferase of anthranilate synthase
I2437_RS00900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I2437_RS00915	COG1609	Transcriptional regulator
I2437_RS00920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2437_RS00920	COG2190	(PTS) system
I2437_RS00920	COG1263	PTS System
I2437_RS00940	COG1196	nuclear chromosome segregation
I2437_RS00940	COG1196	nuclear chromosome segregation
I2437_RS00950	COG1490	D-aminoacyl-tRNA deacylase activity
I2437_RS00965	COG3842	ATPase activity
I2437_RS00980	COG1862	Preprotein translocase
I2437_RS00990	COG4589	Belongs to the CDS family
I2437_RS01000	COG0442	prolyl-tRNA aminoacylation
I2437_RS01015	COG1846	Transcriptional regulator
I2437_RS01020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I2437_RS01055	COG1045	serine acetyltransferase
I2437_RS01065	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I2437_RS01075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2437_RS01090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I2437_RS01095	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I2437_RS01125	COG1674	ftsk spoiiie
I2437_RS01155	COG2017	converts alpha-aldose to the beta-anomer
I2437_RS01160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2437_RS01165	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2437_RS01170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I2437_RS01175	COG1609	Transcriptional regulator
I2437_RS01180	COG1597	lipid kinase activity
I2437_RS01190	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2437_RS01300	COG0527	aspartate kinase activity
I2437_RS01305	COG0101	tRNA pseudouridine synthase activity
I2437_RS01310	COG0351	phosphomethylpyrimidine kinase
I2437_RS01310	COG0352	thiamine-phosphate diphosphorylase activity
I2437_RS01315	COG4720	Psort location CytoplasmicMembrane, score
I2437_RS01325	COG0668	transmembrane transport
I2437_RS01330	COG0366	Alpha amylase catalytic
I2437_RS01345	COG0504	CTP synthase activity
I2437_RS01360	COG0191	fructose-bisphosphate aldolase activity
I2437_RS01395	COG1126	abc transporter atp-binding protein
I2437_RS01400	COG0765	amino acid transport
I2437_RS01405	COG1968	undecaprenyl-diphosphatase activity
I2437_RS01415	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2437_RS01425	COG0719	Fe-S assembly protein
I2437_RS01430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2437_RS01440	COG0719	Fe-S assembly protein
I2437_RS01450	COG1686	Belongs to the peptidase S11 family
I2437_RS01455	COG1686	Belongs to the peptidase S11 family
I2437_RS01460	COG4166	transmembrane transport
I2437_RS01465	COG0601	transmembrane transport
I2437_RS01470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2437_RS01475	COG0444	Belongs to the ABC transporter superfamily
I2437_RS01520	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I2437_RS01525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2437_RS01530	COG1534	Rna-binding protein
I2437_RS01535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2437_RS01540	COG1713	HD superfamily hydrolase involved in NAD metabolism
I2437_RS01545	COG0799	negative regulation of ribosome biogenesis
I2437_RS01550	COG2226	methyltransferase
I2437_RS01560	COG0789	Transcriptional regulator
I2437_RS01570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2437_RS01575	COG1464	Belongs to the NlpA lipoprotein family
I2437_RS01580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2437_RS01595	COG1114	Component of the transport system for branched-chain amino acids
I2437_RS01605	COG0569	domain protein
I2437_RS01610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I2437_RS01620	COG1704	LemA family
I2437_RS01635	COG0745	RESPONSE REGULATOR receiver
I2437_RS01640	COG5002	protein histidine kinase activity
I2437_RS01655	COG1484	DNA-dependent DNA replication
I2437_RS01685	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I2437_RS01700	COG1254	Belongs to the acylphosphatase family
I2437_RS01705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2437_RS01750	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I2437_RS01760	COG1187	pseudouridine synthase activity
I2437_RS01820	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I2437_RS01825	COG0671	phosphoesterase, PA-phosphatase related
I2437_RS01830	COG1242	4 iron, 4 sulfur cluster binding
I2437_RS01835	COG3231	kanamycin kinase activity
I2437_RS01840	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I2437_RS01845	COG1253	flavin adenine dinucleotide binding
I2437_RS01850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2437_RS01855	COG1227	inorganic diphosphatase activity
I2437_RS01865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2437_RS01870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2437_RS01875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I2437_RS01880	COG1120	ATPase activity
I2437_RS01890	COG2244	polysaccharide biosynthetic process
I2437_RS01910	COG4471	UPF0298 protein
I2437_RS01920	COG0470	DNA polymerase III
I2437_RS01925	COG1774	PSP1 C-terminal conserved region
I2437_RS01980	COG1131	(ABC) transporter
I2437_RS02020	COG0768	penicillin binding
I2437_RS02030	COG0513	Belongs to the DEAD box helicase family
I2437_RS02045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2437_RS02055	COG1126	abc transporter atp-binding protein
I2437_RS02065	COG0492	ferredoxin-NADP+ reductase activity
I2437_RS02070	COG1113	amino acid transport
I2437_RS02075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I2437_RS02080	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I2437_RS02085	COG3579	cysteine-type endopeptidase activity
I2437_RS02095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2437_RS02120	COG0116	Belongs to the methyltransferase superfamily
I2437_RS02130	COG1854	S-ribosylhomocysteine lyase activity
I2437_RS02150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I2437_RS02155	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I2437_RS02160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2437_RS02160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2437_RS02170	COG2815	serine threonine protein kinase
I2437_RS02170	COG0515	serine threonine protein kinase
I2437_RS02180	COG4585	Histidine kinase
I2437_RS02185	COG2197	response regulator
I2437_RS02195	COG1098	S1 RNA binding domain
I2437_RS02205	COG1739	Uncharacterized protein family UPF0029
I2437_RS02210	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I2437_RS02215	COG1040	competence protein
I2437_RS02325	COG3290	protein histidine kinase activity
I2437_RS02340	COG2274	protein secretion by the type I secretion system
I2437_RS02395	COG0383	alpha-mannosidase activity
I2437_RS02410	COG3291	Pkd domain containing protein
I2437_RS02410	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I2437_RS02415	COG2723	6-phospho-beta-galactosidase activity
I2437_RS02425	COG1940	carbohydrate kinase activity
I2437_RS02430	COG1175	transmembrane transport
I2437_RS02435	COG0395	ABC-type sugar transport system, permease component
I2437_RS02440	COG1653	transport
I2437_RS02450	COG2972	Histidine kinase
I2437_RS02455	COG2207	Transcriptional regulator
I2437_RS02455	COG4753	response regulator
I2437_RS02460	COG3250	beta-galactosidase activity
I2437_RS02480	COG1605	Chorismate mutase
I2437_RS02480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I2437_RS02510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2437_RS02525	COG1376	ErfK ybiS ycfS ynhG family protein
I2437_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
I2437_RS02550	COG0673	inositol 2-dehydrogenase activity
I2437_RS02570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I2437_RS02640	COG0747	negative chemotaxis
I2437_RS02645	COG0601	transmembrane transport
I2437_RS02650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2437_RS02655	COG0444	Belongs to the ABC transporter superfamily
I2437_RS02690	COG1702	phosphate starvation-inducible protein PhoH
I2437_RS02695	COG1573	uracil-dna glycosylase
I2437_RS02710	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I2437_RS02725	COG1131	(ABC) transporter
I2437_RS02735	COG0583	DNA-binding transcription factor activity
I2437_RS02740	COG0183	Belongs to the thiolase family
I2437_RS02745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I2437_RS02755	COG1028	Short-chain dehydrogenase reductase Sdr
I2437_RS02760	COG2610	gluconate transmembrane transporter activity
I2437_RS02775	COG1940	carbohydrate kinase activity
I2437_RS02785	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2437_RS02790	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2437_RS02795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2437_RS02800	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2437_RS02835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2437_RS02845	COG0557	exoribonuclease II activity
I2437_RS02855	COG0463	Glycosyl transferase, family 2
I2437_RS02860	COG0778	Nitroreductase
I2437_RS02875	COG2274	protein secretion by the type I secretion system
I2437_RS02880	COG0006	proline dipeptidase activity
I2437_RS02885	COG1609	Transcriptional regulator
I2437_RS02900	COG0438	transferase activity, transferring glycosyl groups
I2437_RS02905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I2437_RS02940	COG1131	(ABC) transporter
I2437_RS02955	COG4555	ABC transporter
I2437_RS02970	COG2376	Dihydroxyacetone kinase
I2437_RS02980	COG2376	Dihydroxyacetone kinase
I2437_RS02985	COG1461	Dihydroxyacetone kinase
I2437_RS02990	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I2437_RS02995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2437_RS03005	COG0183	Belongs to the thiolase family
I2437_RS03020	COG0745	RESPONSE REGULATOR receiver
I2437_RS03025	COG5002	protein histidine kinase activity
I2437_RS03030	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I2437_RS03050	COG0571	ribonuclease III activity
I2437_RS03055	COG1196	nuclear chromosome segregation
I2437_RS03090	COG1136	(ABC) transporter
I2437_RS03100	COG0561	phosphatase activity
I2437_RS03105	COG0561	phosphatase activity
I2437_RS03110	COG0552	protein localization to endoplasmic reticulum
I2437_RS03115	COG3711	transcriptional antiterminator
I2437_RS03120	COG2190	(PTS) system
I2437_RS03120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2437_RS03120	COG1263	PTS System
I2437_RS03130	COG3689	TIGRFAM TIGR03943 family protein
I2437_RS03135	COG0701	Predicted permease
I2437_RS03145	COG0745	RESPONSE REGULATOR receiver
I2437_RS03150	COG5002	protein histidine kinase activity
I2437_RS03155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I2437_RS03160	COG0573	inorganic phosphate transmembrane transporter activity
I2437_RS03170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I2437_RS03180	COG2183	response to ionizing radiation
I2437_RS03185	COG3091	SprT-like family
I2437_RS03225	COG0826	peptidase U32
I2437_RS03235	COG4443	Transcriptional Coactivator p15 (PC4)
I2437_RS03250	COG2814	Major facilitator Superfamily
I2437_RS03300	COG1191	sigma factor activity
I2437_RS03340	COG1078	dGTPase activity
I2437_RS03375	COG1609	Transcriptional regulator
I2437_RS03380	COG3716	PTS system mannose fructose sorbose family IID component
I2437_RS03385	COG3715	PTS system
I2437_RS03390	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2437_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
I2437_RS03415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2437_RS03420	COG0800	Aldolase
I2437_RS03425	COG5492	domain, Protein
I2437_RS03435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I2437_RS03455	COG4868	Belongs to the UPF0371 family
I2437_RS03460	COG2814	Major facilitator Superfamily
I2437_RS03470	COG1187	pseudouridine synthase activity
I2437_RS03475	COG2309	aminopeptidase activity
I2437_RS03485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I2437_RS03500	COG2723	6-phospho-beta-galactosidase activity
I2437_RS03510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2437_RS03510	COG3711	transcriptional antiterminator
I2437_RS03520	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2437_RS03530	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2437_RS03540	COG1126	abc transporter atp-binding protein
I2437_RS03545	COG0765	amino acid transport
I2437_RS03550	COG0556	nucleotide-excision repair
I2437_RS03565	COG1696	Membrane protein involved in D-alanine export
I2437_RS03575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I2437_RS03580	COG0657	acetylesterase activity
I2437_RS03585	COG2182	Extracellular solute-binding protein
I2437_RS03590	COG0366	Alpha amylase catalytic
I2437_RS03600	COG1175	transmembrane transport
I2437_RS03605	COG3833	ABC-type maltose transport systems, permease component
I2437_RS03615	COG3833	ABC-type maltose transport systems, permease component
I2437_RS03620	COG1175	transmembrane transport
I2437_RS03630	COG1609	Transcriptional regulator
I2437_RS03635	COG1640	4-alpha-glucanotransferase
I2437_RS03640	COG0058	SHG alpha-glucan phosphorylase activity
I2437_RS03655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I2437_RS03660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I2437_RS03665	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2437_RS03670	COG1234	tRNA 3'-trailer cleavage
I2437_RS03675	COG0300	oxidoreductase activity
I2437_RS03680	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I2437_RS03680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I2437_RS03700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I2437_RS03705	COG2384	SAM-dependent methyltransferase
I2437_RS03715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I2437_RS03720	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I2437_RS03730	COG1088	dTDP-glucose 4,6-dehydratase activity
I2437_RS03735	COG1051	belongs to the nudix hydrolase family
I2437_RS03740	COG0628	permease
I2437_RS03745	COG0457	Tetratricopeptide repeat
I2437_RS03750	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I2437_RS03765	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
I2437_RS03780	COG0488	(ABC) transporter
I2437_RS03785	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I2437_RS03790	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2437_RS03790	COG0022	dehydrogenase e1 component
I2437_RS03805	COG0095	Lipoate-protein ligase
I2437_RS03810	COG3442	glutamine amidotransferase
I2437_RS03815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2437_RS03820	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I2437_RS03840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I2437_RS03875	COG0481	GTPase activity
I2437_RS03900	COG3715	PTS system
I2437_RS03905	COG3716	PTS system mannose fructose sorbose family IID component
I2437_RS03910	COG2972	Histidine kinase
I2437_RS03915	COG4753	response regulator
I2437_RS03915	COG2207	Transcriptional regulator
I2437_RS03935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2437_RS04005	COG0583	DNA-binding transcription factor activity
I2437_RS04015	COG0284	orotidine-5'-phosphate decarboxylase activity
I2437_RS04020	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I2437_RS04035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2437_RS04040	COG0765	amino acid transport
I2437_RS04065	COG0187	DNA topoisomerase II activity
I2437_RS04080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I2437_RS04100	COG0539	negative regulation of cytoplasmic translation
I2437_RS04145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I2437_RS04150	COG0583	DNA-binding transcription factor activity
I2437_RS04160	COG0564	pseudouridine synthase activity
I2437_RS04195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2437_RS04200	COG1136	(ABC) transporter
I2437_RS04205	COG0577	efflux transmembrane transporter activity
I2437_RS04225	COG1837	Belongs to the UPF0109 family
I2437_RS04245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I2437_RS04270	COG1349	DNA-binding transcription factor activity
I2437_RS04275	COG1105	Belongs to the carbohydrate kinase PfkB family
I2437_RS04280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2437_RS04280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2437_RS04280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2437_RS04285	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2437_RS04285	COG1388	LysM domain
I2437_RS04315	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2437_RS04315	COG1388	LysM domain
I2437_RS04335	COG0488	(ABC) transporter
I2437_RS04350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I2437_RS04355	COG0242	peptide deformylase activity
I2437_RS04360	COG0737	Belongs to the 5'-nucleotidase family
I2437_RS04365	COG1132	(ABC) transporter
I2437_RS04370	COG1132	(ABC) transporter
I2437_RS04400	COG3425	synthase
I2437_RS04410	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I2437_RS04420	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I2437_RS04425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I2437_RS04440	COG0105	UTP biosynthetic process
I2437_RS04450	COG0726	polysaccharide deacetylase
I2437_RS04465	COG0285	dihydrofolate synthase activity
I2437_RS04470	COG0302	gtp cyclohydrolase
I2437_RS04485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I2437_RS04500	COG1176	ABC-type spermidine putrescine transport system, permease component I
I2437_RS04505	COG1177	transmembrane transport
I2437_RS04525	COG0628	permease
I2437_RS04535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I2437_RS04550	COG1104	cysteine desulfurase activity
I2437_RS04560	COG4116	CYTH
I2437_RS04565	COG2357	RelA SpoT domain protein
I2437_RS04575	COG0564	pseudouridine synthase activity
I2437_RS04580	COG0280	phosphate acetyltransferase
I2437_RS04585	COG4221	oxidoreductase activity
I2437_RS04600	COG1174	glycine betaine transport
I2437_RS04605	COG0516	GMP reductase activity
I2437_RS04610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2437_RS04620	COG1942	4-Oxalocrotonate Tautomerase
I2437_RS04635	COG2890	protein-(glutamine-N5) methyltransferase activity
I2437_RS04640	COG0009	L-threonylcarbamoyladenylate synthase
I2437_RS04650	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I2437_RS04680	COG3764	Sortase (surface protein transpeptidase)
I2437_RS04685	COG0346	lactoylglutathione lyase activity
I2437_RS04690	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2437_RS04710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I2437_RS04720	COG2188	Transcriptional regulator
I2437_RS04745	COG4974	Belongs to the 'phage' integrase family
I2437_RS04790	COG1396	sequence-specific DNA binding
I2437_RS04800	COG4974	Belongs to the 'phage' integrase family
I2437_RS04805	COG5002	protein histidine kinase activity
I2437_RS04810	COG0745	RESPONSE REGULATOR receiver
I2437_RS04815	COG0577	efflux transmembrane transporter activity
I2437_RS04820	COG1136	(ABC) transporter
I2437_RS04850	COG3052	prosthetic group binding
I2437_RS04855	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I2437_RS04860	COG0511	ligase activity, forming carbon-carbon bonds
I2437_RS04870	COG2851	Citrate transporter
I2437_RS04890	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I2437_RS04910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2437_RS04915	COG0758	DNA mediated transformation
I2437_RS04925	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2437_RS04930	COG0577	efflux transmembrane transporter activity
I2437_RS04930	COG1136	(ABC) transporter
I2437_RS04960	COG2226	methyltransferase
I2437_RS04970	COG1272	protein, Hemolysin III
I2437_RS04975	COG1597	lipid kinase activity
I2437_RS04985	COG0488	(ABC) transporter
I2437_RS05000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2437_RS05005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I2437_RS05005	COG1328	CTP reductase activity
I2437_RS05010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I2437_RS05015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I2437_RS05025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I2437_RS05035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I2437_RS05040	COG4684	Psort location CytoplasmicMembrane, score
I2437_RS05050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2437_RS05055	COG1079	Belongs to the binding-protein-dependent transport system permease family
I2437_RS05060	COG4603	Belongs to the binding-protein-dependent transport system permease family
I2437_RS05065	COG3845	ABC transporter
I2437_RS05070	COG1744	ABC transporter substrate-binding protein PnrA-like
I2437_RS05085	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I2437_RS05090	COG2813	Specifically methylates the guanine in position
I2437_RS05095	COG1072	(Pantothenic acid kinase))
I2437_RS05135	COG5002	protein histidine kinase activity
I2437_RS05140	COG0745	RESPONSE REGULATOR receiver
I2437_RS05150	COG0704	Plays a role in the regulation of phosphate uptake
I2437_RS05165	COG0581	inorganic phosphate transmembrane transporter activity
I2437_RS05170	COG0573	inorganic phosphate transmembrane transporter activity
I2437_RS05180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2437_RS05180	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I2437_RS05185	COG0483	inositol monophosphate 1-phosphatase activity
I2437_RS05200	COG0196	riboflavin kinase activity
I2437_RS05230	COG4591	ABC-type transport system involved in lipoprotein release permease component
I2437_RS05230	COG1136	(ABC) transporter
I2437_RS05280	COG1115	amino acid carrier protein
I2437_RS05285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I2437_RS05290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2437_RS05295	COG1126	abc transporter atp-binding protein
I2437_RS05300	COG0765	amino acid transport
I2437_RS05305	COG2824	Alkylphosphonate utilization operon protein PhnA
I2437_RS05320	COG0469	pyruvate kinase activity
I2437_RS05335	COG1725	Transcriptional regulator
I2437_RS05340	COG1131	(ABC) transporter
I2437_RS05380	COG1104	cysteine desulfurase activity
I2437_RS05390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2437_RS05410	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I2437_RS05415	COG1368	sulfuric ester hydrolase activity
I2437_RS05465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2437_RS05470	COG1368	sulfuric ester hydrolase activity
I2437_RS05475	COG0297	glycogen (starch) synthase activity
I2437_RS05495	COG0463	Glycosyl transferase, family 2
I2437_RS05520	COG1215	transferase activity, transferring glycosyl groups
I2437_RS05530	COG1091	dTDP-4-dehydrorhamnose reductase activity
I2437_RS05535	COG2151	metal-sulfur cluster biosynthetic enzyme
I2437_RS05540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I2437_RS05545	COG0358	DNA primase activity
I2437_RS05550	COG1970	mechanosensitive ion channel activity
I2437_RS05560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2437_RS05565	COG0436	Aminotransferase
I2437_RS05570	COG1074	ATP-dependent DNA helicase activity
I2437_RS05610	COG1595	DNA-templated transcription, initiation
I2437_RS05615	COG1523	belongs to the glycosyl hydrolase 13 family
I2437_RS05665	COG1309	transcriptional regulator
I2437_RS05680	COG0577	efflux transmembrane transporter activity
I2437_RS05720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I2437_RS05760	COG0058	SHG alpha-glucan phosphorylase activity
I2437_RS05765	COG0297	glycogen (starch) synthase activity
I2437_RS05770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2437_RS05775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2437_RS05780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I2437_RS05785	COG1523	belongs to the glycosyl hydrolase 13 family
I2437_RS05790	COG1597	lipid kinase activity
I2437_RS05800	COG4708	membrane
I2437_RS05855	COG0772	Belongs to the SEDS family
I2437_RS05860	COG1012	belongs to the aldehyde dehydrogenase family
I2437_RS05870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2437_RS05875	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I2437_RS05880	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2437_RS05900	COG1476	TRANSCRIPTIONal
I2437_RS05920	COG0038	chloride channel
I2437_RS05930	COG0716	FMN binding
I2437_RS05940	COG2153	protein acetylation
I2437_RS05945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I2437_RS05960	COG3716	PTS system mannose fructose sorbose family IID component
I2437_RS05965	COG3715	PTS system
I2437_RS05970	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2437_RS05970	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2437_RS05980	COG2188	Transcriptional regulator
I2437_RS05985	COG3684	Belongs to the aldolase LacD family
I2437_RS05990	COG2222	sugar isomerase
I2437_RS05995	COG2188	Transcriptional regulator
I2437_RS06025	COG1660	Displays ATPase and GTPase activities
I2437_RS06035	COG0017	Asparaginyl-tRNA synthetase
I2437_RS06040	COG0436	Aminotransferase
I2437_RS06050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2437_RS06050	COG1199	ATP-dependent helicase activity
I2437_RS06060	COG2177	Part of the ABC transporter FtsEX involved in
I2437_RS06065	COG2884	Cell division ATP-binding protein ftsE
I2437_RS06085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I2437_RS06095	COG1396	sequence-specific DNA binding
I2437_RS06100	COG0772	Belongs to the SEDS family
I2437_RS06110	COG1164	Oligoendopeptidase f
I2437_RS06115	COG0386	Belongs to the glutathione peroxidase family
I2437_RS06140	COG3859	Proton-coupled thiamine transporter YuaJ
I2437_RS06145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I2437_RS06155	COG0588	phosphoglycerate mutase activity
I2437_RS06200	COG0551	DNA topoisomerase type I activity
I2437_RS06200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2437_RS06330	COG1484	DNA-dependent DNA replication
I2437_RS06355	COG1316	TRANSCRIPTIONal
I2437_RS06365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I2437_RS06375	COG0024	Methionine aminopeptidase
I2437_RS06380	COG4109	DRTGG domain
I2437_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
I2437_RS06420	COG0800	Aldolase
I2437_RS06425	COG2186	Transcriptional regulator
I2437_RS06430	COG3250	beta-galactosidase activity
I2437_RS06440	COG2211	Major facilitator Superfamily
I2437_RS06460	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I2437_RS06460	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I2437_RS06470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I2437_RS06475	COG1956	GAF domain-containing protein
I2437_RS06495	COG0513	Belongs to the DEAD box helicase family
I2437_RS06500	COG0726	polysaccharide deacetylase
I2437_RS06515	COG4122	O-methyltransferase activity
I2437_RS06520	COG0546	phosphoglycolate phosphatase activity
I2437_RS06545	COG1187	pseudouridine synthase activity
I2437_RS06575	COG0658	competence protein
I2437_RS06575	COG2333	competence protein COMEC
I2437_RS06585	COG0204	Acyl-transferase
I2437_RS06590	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I2437_RS06605	COG0513	Belongs to the DEAD box helicase family
I2437_RS06620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2437_RS06625	COG1181	Belongs to the D-alanine--D-alanine ligase family
I2437_RS06635	COG0768	penicillin binding
I2437_RS06640	COG2116	formate transmembrane transporter activity
I2437_RS06650	COG1827	regulation of RNA biosynthetic process
I2437_RS06670	COG1396	sequence-specific DNA binding
I2437_RS06690	COG4698	Protein conserved in bacteria
I2437_RS06695	COG2755	lipolytic protein G-D-S-L family
I2437_RS06710	COG0497	DNA recombination
I2437_RS06715	COG1438	arginine binding
I2437_RS06720	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I2437_RS06740	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I2437_RS06745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I2437_RS06750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2437_RS06755	COG1126	abc transporter atp-binding protein
I2437_RS06760	COG0765	amino acid transport
I2437_RS06770	COG4703	Protein of unknown function (DUF1797)
I2437_RS06775	COG0542	response to heat
I2437_RS06780	COG0494	nUDIX hydrolase
I2437_RS06795	COG3599	regulation of cell shape
I2437_RS06815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I2437_RS06825	COG0849	cell division
I2437_RS06850	COG1217	gtp-binding protein TYPA
I2437_RS06855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I2437_RS06860	COG1940	carbohydrate kinase activity
I2437_RS06865	COG4483	Protein conserved in bacteria
I2437_RS06870	COG0783	Belongs to the Dps family
I2437_RS06885	COG4470	Protein conserved in bacteria
I2437_RS06890	COG3480	Lon protease (S16) C-terminal proteolytic domain
I2437_RS06895	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I2437_RS06900	COG0742	ribosomal rna small subunit methyltransferase
I2437_RS06910	COG0549	Belongs to the carbamate kinase family
I2437_RS06915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2437_RS06920	COG1288	antiporter activity
I2437_RS06930	COG0454	-acetyltransferase
I2437_RS06940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2437_RS06960	COG2315	Protein conserved in bacteria
I2437_RS06965	COG2972	Histidine kinase
I2437_RS06970	COG4753	response regulator
I2437_RS06970	COG2207	Transcriptional regulator
I2437_RS06980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2437_RS06985	COG0785	Cytochrome C biogenesis protein
I2437_RS06990	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I2437_RS06995	COG1518	maintenance of DNA repeat elements
I2437_RS07110	COG1114	Component of the transport system for branched-chain amino acids
I2437_RS07135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2437_RS07140	COG2274	protein secretion by the type I secretion system
I2437_RS07195	COG0708	Exodeoxyribonuclease III
I2437_RS07200	COG1393	Belongs to the ArsC family
I2437_RS07205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I2437_RS07245	COG1131	(ABC) transporter
I2437_RS07285	COG0751	glycine-tRNA ligase activity
I2437_RS07295	COG1755	Isoprenylcysteine carboxyl methyltransferase
I2437_RS07320	COG0656	L-ascorbic acid biosynthetic process
I2437_RS07330	COG1283	sodium-dependent phosphate transmembrane transporter activity
I2437_RS07340	COG1879	ABC-type sugar transport system periplasmic component
I2437_RS07345	COG1172	Belongs to the binding-protein-dependent transport system permease family
I2437_RS07355	COG1869	D-ribose catabolic process
I2437_RS07360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2437_RS07365	COG1609	Transcriptional regulator
I2437_RS07380	COG0561	phosphatase activity
I2437_RS07385	COG2860	membrane
I2437_RS07395	COG2723	6-phospho-beta-galactosidase activity
I2437_RS07400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2437_RS07400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2437_RS07405	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2437_RS07410	COG3711	transcriptional antiterminator
I2437_RS07420	COG1105	Belongs to the carbohydrate kinase PfkB family
I2437_RS07450	COG2217	Heavy metal translocating P-type atpase
I2437_RS07480	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I2437_RS07485	COG0195	Participates in both transcription termination and antitermination
I2437_RS07515	COG4473	ABC transporter
I2437_RS07520	COG1131	(ABC) transporter
I2437_RS07530	COG0537	adenosine 5'-monophosphoramidase activity
I2437_RS07540	COG1316	TRANSCRIPTIONal
I2437_RS07550	COG0802	atpase or kinase
I2437_RS07555	COG2252	PERMEase
I2437_RS07560	COG0561	phosphatase activity
I2437_RS07570	COG3715	PTS system
I2437_RS07575	COG3716	PTS system mannose fructose sorbose family IID component
I2437_RS07605	COG0439	Biotin carboxylase
I2437_RS07620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2437_RS07625	COG1028	Short-chain dehydrogenase reductase Sdr
I2437_RS07630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I2437_RS07635	COG2070	2-Nitropropane dioxygenase
I2437_RS07645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I2437_RS07655	COG1024	Enoyl-CoA hydratase
I2437_RS07675	COG1420	regulation of RNA biosynthetic process
I2437_RS07685	COG1876	peptidase activity
I2437_RS07690	COG0588	phosphoglycerate mutase activity
I2437_RS07700	COG3830	Belongs to the UPF0237 family
I2437_RS07710	COG2261	transglycosylase associated protein
I2437_RS07715	COG0697	spore germination
I2437_RS07735	COG1335	isochorismatase
I2437_RS07740	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I2437_RS07745	COG0436	Aminotransferase
I2437_RS07755	COG0561	phosphatase activity
I2437_RS07760	COG0252	asparaginase activity
I2437_RS07765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I2437_RS07770	COG1129	ABC transporter
I2437_RS07785	COG1132	(ABC) transporter
I2437_RS07790	COG4988	ABC transporter
I2437_RS07795	COG1120	ATPase activity
I2437_RS07820	COG3942	CHAP domain
I2437_RS07820	COG1388	LysM domain
I2437_RS07835	COG0653	protein targeting
I2437_RS07840	COG1482	cell wall glycoprotein biosynthetic process
I2437_RS07845	COG1940	carbohydrate kinase activity
I2437_RS07855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2437_RS07855	COG2190	(PTS) system
I2437_RS07855	COG1263	PTS System
I2437_RS07860	COG1621	beta-fructofuranosidase activity
I2437_RS07865	COG1609	Transcriptional regulator
I2437_RS07890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2437_RS07905	COG2131	deaminase
I2437_RS07910	COG0006	proline dipeptidase activity
I2437_RS07955	COG1194	a g-specific adenine glycosylase
I2437_RS07970	COG3118	belongs to the thioredoxin family
I2437_RS07975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2437_RS08000	COG0681	Belongs to the peptidase S26 family
I2437_RS08005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I2437_RS08020	COG1882	Formate acetyltransferase
I2437_RS08030	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2437_RS08040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2437_RS08050	COG2814	Major facilitator Superfamily
I2437_RS08055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2437_RS08095	COG5002	protein histidine kinase activity
I2437_RS08110	COG1598	PFAM Uncharacterised protein family UPF0150
I2437_RS08130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I2437_RS08135	COG0789	Transcriptional regulator
I2437_RS08150	COG2081	HI0933 family
I2437_RS08175	COG1214	PFAM Peptidase M22, glycoprotease
I2437_RS08180	COG5503	Protein of unknown function (DUF1447)
I2437_RS08190	COG4608	Belongs to the ABC transporter superfamily
I2437_RS08195	COG0444	Belongs to the ABC transporter superfamily
I2437_RS08200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2437_RS08205	COG0601	transmembrane transport
I2437_RS08210	COG4166	transmembrane transport
I2437_RS08215	COG0174	glutamine synthetase
I2437_RS08220	COG0789	Transcriptional regulator
I2437_RS08235	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I2437_RS08265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2437_RS08280	COG1564	THIamine pyrophosphokinase
I2437_RS08305	COG0084	hydrolase, TatD family'
I2437_RS08310	COG1737	Transcriptional regulator
I2437_RS08315	COG3458	cephalosporin-C deacetylase activity
I2437_RS08325	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2437_RS08335	COG2731	YhcH YjgK YiaL family protein
I2437_RS08340	COG0395	ABC-type sugar transport system, permease component
I2437_RS08345	COG1175	transmembrane transport
I2437_RS08365	COG1263	PTS System
I2437_RS08365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2437_RS08365	COG2190	(PTS) system
I2437_RS08370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2437_RS08370	COG2190	(PTS) system
I2437_RS08370	COG1263	PTS System
I2437_RS08410	COG1847	R3H domain protein
I2437_RS08465	COG0756	dUTP diphosphatase activity
I2437_RS08475	COG1132	(ABC) transporter
I2437_RS08480	COG1132	(ABC) transporter
I2437_RS08500	COG0457	Tetratricopeptide repeat
I2437_RS08500	COG0705	Rhomboid family
I2437_RS08505	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I2437_RS08525	COG3732	PTS system glucitol sorbitol-specific
I2437_RS08530	COG3730	PTS system glucitol sorbitol-specific
I2437_RS08540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2437_RS08540	COG3711	transcriptional antiterminator
I2437_RS08570	COG1215	transferase activity, transferring glycosyl groups
I2437_RS08595	COG1234	tRNA 3'-trailer cleavage
I2437_RS08600	COG1268	BioY protein
I2437_RS08650	COG1832	CoA-binding protein
I2437_RS08655	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2437_RS08655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2437_RS08665	COG3448	diguanylate cyclase activity
I2437_RS08665	COG4175	Glycine betaine
I2437_RS08685	COG3623	hexulose-6-phosphate isomerase
I2437_RS08705	COG3037	sugar-specific permease SgaT UlaA
I2437_RS08745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2437_RS08765	COG0564	pseudouridine synthase activity
I2437_RS08785	COG1116	anion transmembrane transporter activity
I2437_RS08805	COG1051	belongs to the nudix hydrolase family
I2437_RS08860	COG4463	regulation of RNA biosynthetic process
I2437_RS08875	COG0450	alkyl hydroperoxide reductase
I2437_RS08900	COG3590	peptidase
I2437_RS08905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I2437_RS08910	COG3959	Transketolase, thiamine diphosphate binding domain
I2437_RS08925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2437_RS08965	COG4537	Required for transformation and DNA binding
I2437_RS08970	COG1459	type II secretion system
I2437_RS08975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I2437_RS08980	COG1136	(ABC) transporter
I2437_RS09015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I2437_RS09025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2437_RS09025	COG4499	WXG100 protein secretion system (Wss), protein YukC
I2437_RS09035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2437_RS09040	COG1121	(ABC) transporter
I2437_RS09055	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I2437_RS09095	COG3022	response to hydroperoxide
I2437_RS09100	COG0602	queuosine metabolic process
I2437_RS09120	COG1328	CTP reductase activity
I2437_RS09135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I2437_RS09145	COG1393	Belongs to the ArsC family
I2437_RS09155	COG1058	Belongs to the CinA family
I2437_RS09155	COG1546	Belongs to the CinA family
I2437_RS09175	COG0519	Catalyzes the synthesis of GMP from XMP
I2437_RS09180	COG0632	four-way junction helicase activity
I2437_RS09185	COG2814	Major facilitator Superfamily
I2437_RS09190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I2437_RS09195	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I2437_RS09205	COG1438	arginine binding
I2437_RS09210	COG0018	arginyl-trna synthetase
I2437_RS09215	COG0488	(ABC) transporter
I2437_RS09220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2437_RS09225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2437_RS09230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2437_RS09235	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I2437_RS09245	COG1131	(ABC) transporter
I2437_RS09280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2437_RS09305	COG2197	response regulator
I2437_RS09320	COG0577	efflux transmembrane transporter activity
I2437_RS09320	COG1136	(ABC) transporter
I2437_RS09360	COG1511	domain protein
I2437_RS09400	COG0305	Participates in initiation and elongation during chromosome replication
I2437_RS09430	COG1760	l-serine dehydratase
I2437_RS09435	COG1760	l-serine dehydratase
I2437_RS09465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I2437_RS09475	COG0612	Peptidase, M16
I2437_RS09485	COG2501	S4 domain
I2437_RS09525	COG0516	GMP reductase activity
I2437_RS09525	COG0517	IMP dehydrogenase activity
I2437_RS09535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2437_RS09540	COG0488	(ABC) transporter
I2437_RS09570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I2437_RS09575	COG1475	DNA binding