locus-tag	class	description
I2439_RS00010	COG0592	DNA-directed DNA polymerase activity
I2439_RS00025	COG0012	GTP binding
I2439_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
I2439_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I2439_RS00040	COG2244	polysaccharide biosynthetic process
I2439_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I2439_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I2439_RS00075	COG0531	amino acid
I2439_RS00195	COG3942	CHAP domain
I2439_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I2439_RS00220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I2439_RS00240	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I2439_RS00245	COG0138	bifunctional purine biosynthesis protein purh
I2439_RS00255	COG0151	Belongs to the GarS family
I2439_RS00260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I2439_RS00275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I2439_RS00290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I2439_RS00305	COG1454	alcohol dehydrogenase
I2439_RS00305	COG1012	belongs to the aldehyde dehydrogenase family
I2439_RS00310	COG1063	alcohol dehydrogenase
I2439_RS00315	COG1064	alcohol dehydrogenase
I2439_RS00320	COG1132	(ABC) transporter
I2439_RS00325	COG1396	sequence-specific DNA binding
I2439_RS00330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I2439_RS00340	COG0051	transcription antitermination factor activity, RNA binding
I2439_RS00350	COG0088	Forms part of the polypeptide exit tunnel
I2439_RS00355	COG0089	rRNA binding
I2439_RS00445	COG0201	protein transport
I2439_RS00585	COG0582	viral genome integration into host DNA
I2439_RS00595	COG2946	Replication initiation factor
I2439_RS00665	COG1121	(ABC) transporter
I2439_RS00670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I2439_RS00680	COG4499	WXG100 protein secretion system (Wss), protein YukC
I2439_RS00680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2439_RS00685	COG0085	RNA polymerase activity
I2439_RS00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I2439_RS00725	COG1136	(ABC) transporter
I2439_RS00730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I2439_RS00735	COG1459	type II secretion system
I2439_RS00780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2439_RS00795	COG3959	Transketolase, thiamine diphosphate binding domain
I2439_RS00800	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I2439_RS00805	COG3590	peptidase
I2439_RS00810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I2439_RS00825	COG0450	alkyl hydroperoxide reductase
I2439_RS00845	COG4463	regulation of RNA biosynthetic process
I2439_RS00890	COG1051	belongs to the nudix hydrolase family
I2439_RS00895	COG1396	sequence-specific DNA binding
I2439_RS00915	COG1116	anion transmembrane transporter activity
I2439_RS00935	COG0564	pseudouridine synthase activity
I2439_RS00955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2439_RS00990	COG0495	leucyl-tRNA aminoacylation
I2439_RS01000	COG3037	sugar-specific permease SgaT UlaA
I2439_RS01020	COG3623	hexulose-6-phosphate isomerase
I2439_RS01045	COG4175	Glycine betaine
I2439_RS01045	COG3448	diguanylate cyclase activity
I2439_RS01055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2439_RS01055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I2439_RS01060	COG1832	CoA-binding protein
I2439_RS01110	COG1268	BioY protein
I2439_RS01115	COG1234	tRNA 3'-trailer cleavage
I2439_RS01140	COG1215	transferase activity, transferring glycosyl groups
I2439_RS01170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2439_RS01170	COG3711	transcriptional antiterminator
I2439_RS01180	COG3730	PTS system glucitol sorbitol-specific
I2439_RS01185	COG3732	PTS system glucitol sorbitol-specific
I2439_RS01210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I2439_RS01215	COG0705	Rhomboid family
I2439_RS01215	COG0457	Tetratricopeptide repeat
I2439_RS01235	COG1132	(ABC) transporter
I2439_RS01240	COG1132	(ABC) transporter
I2439_RS01250	COG0756	dUTP diphosphatase activity
I2439_RS01310	COG1847	R3H domain protein
I2439_RS01405	COG2190	(PTS) system
I2439_RS01405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2439_RS01405	COG1263	PTS System
I2439_RS01410	COG1263	PTS System
I2439_RS01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2439_RS01410	COG2190	(PTS) system
I2439_RS01435	COG1175	transmembrane transport
I2439_RS01440	COG0395	ABC-type sugar transport system, permease component
I2439_RS01445	COG2731	YhcH YjgK YiaL family protein
I2439_RS01455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I2439_RS01465	COG3458	cephalosporin-C deacetylase activity
I2439_RS01470	COG1737	Transcriptional regulator
I2439_RS01475	COG0084	hydrolase, TatD family'
I2439_RS01505	COG1564	THIamine pyrophosphokinase
I2439_RS01520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2439_RS01555	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I2439_RS01570	COG0789	Transcriptional regulator
I2439_RS01575	COG0174	glutamine synthetase
I2439_RS01580	COG4166	transmembrane transport
I2439_RS01585	COG0601	transmembrane transport
I2439_RS01590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2439_RS01595	COG0444	Belongs to the ABC transporter superfamily
I2439_RS01600	COG4608	Belongs to the ABC transporter superfamily
I2439_RS01615	COG1214	PFAM Peptidase M22, glycoprotease
I2439_RS01630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I2439_RS01640	COG2081	HI0933 family
I2439_RS01655	COG0789	Transcriptional regulator
I2439_RS01660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I2439_RS01675	COG5002	protein histidine kinase activity
I2439_RS01710	COG2936	dipeptidyl-peptidase activity
I2439_RS01715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I2439_RS01720	COG2814	Major facilitator Superfamily
I2439_RS01730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2439_RS01740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I2439_RS01750	COG1882	Formate acetyltransferase
I2439_RS01765	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I2439_RS01770	COG0681	Belongs to the peptidase S26 family
I2439_RS01785	COG1286	toxin biosynthetic process
I2439_RS01795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2439_RS01800	COG3118	belongs to the thioredoxin family
I2439_RS01815	COG1194	a g-specific adenine glycosylase
I2439_RS01855	COG0006	proline dipeptidase activity
I2439_RS01860	COG2131	deaminase
I2439_RS01900	COG1609	Transcriptional regulator
I2439_RS01905	COG1621	beta-fructofuranosidase activity
I2439_RS01910	COG2190	(PTS) system
I2439_RS01910	COG1263	PTS System
I2439_RS01910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2439_RS01925	COG1482	cell wall glycoprotein biosynthetic process
I2439_RS01930	COG0653	protein targeting
I2439_RS01940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I2439_RS01945	COG1388	LysM domain
I2439_RS01945	COG3942	CHAP domain
I2439_RS01970	COG1120	ATPase activity
I2439_RS01975	COG4988	ABC transporter
I2439_RS01980	COG1132	(ABC) transporter
I2439_RS01995	COG1129	ABC transporter
I2439_RS02000	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I2439_RS02005	COG0252	asparaginase activity
I2439_RS02010	COG0561	phosphatase activity
I2439_RS02020	COG0436	Aminotransferase
I2439_RS02025	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I2439_RS02030	COG1335	isochorismatase
I2439_RS02050	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I2439_RS02055	COG0697	spore germination
I2439_RS02060	COG2261	transglycosylase associated protein
I2439_RS02070	COG3830	Belongs to the UPF0237 family
I2439_RS02075	COG2848	UPF0210 protein
I2439_RS02080	COG0588	phosphoglycerate mutase activity
I2439_RS02085	COG1876	peptidase activity
I2439_RS02110	COG0484	heat shock protein binding
I2439_RS02115	COG1024	Enoyl-CoA hydratase
I2439_RS02125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I2439_RS02135	COG2070	2-Nitropropane dioxygenase
I2439_RS02140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I2439_RS02145	COG1028	Short-chain dehydrogenase reductase Sdr
I2439_RS02150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I2439_RS02165	COG0439	Biotin carboxylase
I2439_RS02170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I2439_RS02180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I2439_RS02195	COG3716	PTS system mannose fructose sorbose family IID component
I2439_RS02200	COG3715	PTS system
I2439_RS02210	COG0561	phosphatase activity
I2439_RS02215	COG2252	PERMEase
I2439_RS02220	COG0802	atpase or kinase
I2439_RS02230	COG1316	TRANSCRIPTIONal
I2439_RS02240	COG0537	adenosine 5'-monophosphoramidase activity
I2439_RS02250	COG1131	(ABC) transporter
I2439_RS02255	COG4473	ABC transporter
I2439_RS02335	COG3620	sequence-specific DNA binding
I2439_RS02410	COG3942	CHAP domain
I2439_RS02410	COG1388	LysM domain
I2439_RS02460	COG3843	relaxase mobilization nuclease domain protein
I2439_RS02485	COG0195	Participates in both transcription termination and antitermination
I2439_RS02490	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I2439_RS02500	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I2439_RS02520	COG2217	Heavy metal translocating P-type atpase
I2439_RS02560	COG3711	transcriptional antiterminator
I2439_RS02565	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2439_RS02570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2439_RS02570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2439_RS02585	COG2860	membrane
I2439_RS02590	COG0561	phosphatase activity
I2439_RS02605	COG1609	Transcriptional regulator
I2439_RS02610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I2439_RS02615	COG1869	D-ribose catabolic process
I2439_RS02625	COG1172	Belongs to the binding-protein-dependent transport system permease family
I2439_RS02630	COG1879	ABC-type sugar transport system periplasmic component
I2439_RS02640	COG1283	sodium-dependent phosphate transmembrane transporter activity
I2439_RS02650	COG0656	L-ascorbic acid biosynthetic process
I2439_RS02660	COG1755	Isoprenylcysteine carboxyl methyltransferase
I2439_RS02670	COG0751	glycine-tRNA ligase activity
I2439_RS02710	COG1131	(ABC) transporter
I2439_RS02750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I2439_RS02755	COG1393	Belongs to the ArsC family
I2439_RS02760	COG0708	Exodeoxyribonuclease III
I2439_RS02820	COG2274	protein secretion by the type I secretion system
I2439_RS02825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2439_RS02850	COG1114	Component of the transport system for branched-chain amino acids
I2439_RS02885	COG0785	Cytochrome C biogenesis protein
I2439_RS02890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2439_RS02900	COG2207	Transcriptional regulator
I2439_RS02900	COG4753	response regulator
I2439_RS02905	COG2972	Histidine kinase
I2439_RS02910	COG2315	Protein conserved in bacteria
I2439_RS02940	COG0454	-acetyltransferase
I2439_RS02950	COG1288	antiporter activity
I2439_RS02955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2439_RS02960	COG0549	Belongs to the carbamate kinase family
I2439_RS02970	COG0742	ribosomal rna small subunit methyltransferase
I2439_RS02975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I2439_RS02980	COG3480	Lon protease (S16) C-terminal proteolytic domain
I2439_RS02985	COG4470	Protein conserved in bacteria
I2439_RS02995	COG0783	Belongs to the Dps family
I2439_RS03000	COG4483	Protein conserved in bacteria
I2439_RS03005	COG1940	carbohydrate kinase activity
I2439_RS03010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I2439_RS03015	COG1217	gtp-binding protein TYPA
I2439_RS03040	COG0849	cell division
I2439_RS03050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I2439_RS03070	COG3599	regulation of cell shape
I2439_RS03090	COG0494	nUDIX hydrolase
I2439_RS03095	COG0542	response to heat
I2439_RS03100	COG4703	Protein of unknown function (DUF1797)
I2439_RS03110	COG0765	amino acid transport
I2439_RS03115	COG1126	abc transporter atp-binding protein
I2439_RS03120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2439_RS03130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I2439_RS03150	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I2439_RS03155	COG1438	arginine binding
I2439_RS03160	COG0497	DNA recombination
I2439_RS03175	COG2755	lipolytic protein G-D-S-L family
I2439_RS03180	COG4698	Protein conserved in bacteria
I2439_RS03220	COG1827	regulation of RNA biosynthetic process
I2439_RS03230	COG2116	formate transmembrane transporter activity
I2439_RS03235	COG0768	penicillin binding
I2439_RS03250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2439_RS03265	COG0513	Belongs to the DEAD box helicase family
I2439_RS03285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I2439_RS03290	COG0204	Acyl-transferase
I2439_RS03300	COG0658	competence protein
I2439_RS03300	COG2333	competence protein COMEC
I2439_RS03330	COG1187	pseudouridine synthase activity
I2439_RS03355	COG0546	phosphoglycolate phosphatase activity
I2439_RS03360	COG4122	O-methyltransferase activity
I2439_RS03380	COG0726	polysaccharide deacetylase
I2439_RS03385	COG0513	Belongs to the DEAD box helicase family
I2439_RS03405	COG1956	GAF domain-containing protein
I2439_RS03410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I2439_RS03420	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I2439_RS03420	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I2439_RS03440	COG2211	Major facilitator Superfamily
I2439_RS03450	COG3250	beta-galactosidase activity
I2439_RS03455	COG2186	Transcriptional regulator
I2439_RS03460	COG0800	Aldolase
I2439_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
I2439_RS03495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2439_RS03500	COG4109	DRTGG domain
I2439_RS03505	COG0024	Methionine aminopeptidase
I2439_RS03525	COG1316	TRANSCRIPTIONal
I2439_RS03530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I2439_RS03545	COG1484	DNA-dependent DNA replication
I2439_RS03580	COG2378	regulation of single-species biofilm formation
I2439_RS03730	COG1196	nuclear chromosome segregation
I2439_RS03735	COG0210	DNA helicase
I2439_RS03760	COG1309	transcriptional regulator
I2439_RS03770	COG1132	(ABC) transporter
I2439_RS03775	COG1129	ABC transporter
I2439_RS03805	COG0588	phosphoglycerate mutase activity
I2439_RS03815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I2439_RS03820	COG3859	Proton-coupled thiamine transporter YuaJ
I2439_RS03840	COG0386	Belongs to the glutathione peroxidase family
I2439_RS03845	COG1164	Oligoendopeptidase f
I2439_RS03855	COG0772	Belongs to the SEDS family
I2439_RS03865	COG1131	(ABC) transporter
I2439_RS03880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I2439_RS03895	COG2884	Cell division ATP-binding protein ftsE
I2439_RS03900	COG2177	Part of the ABC transporter FtsEX involved in
I2439_RS03910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2439_RS03910	COG1199	ATP-dependent helicase activity
I2439_RS03910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I2439_RS03910	COG1199	ATP-dependent helicase activity
I2439_RS03920	COG0436	Aminotransferase
I2439_RS03925	COG0017	Asparaginyl-tRNA synthetase
I2439_RS03960	COG2188	Transcriptional regulator
I2439_RS03965	COG2222	sugar isomerase
I2439_RS03970	COG3684	Belongs to the aldolase LacD family
I2439_RS03975	COG2188	Transcriptional regulator
I2439_RS03985	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2439_RS03985	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2439_RS03990	COG3715	PTS system
I2439_RS03995	COG3716	PTS system mannose fructose sorbose family IID component
I2439_RS04005	COG0254	rRNA binding
I2439_RS04010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I2439_RS04015	COG2153	protein acetylation
I2439_RS04025	COG0716	FMN binding
I2439_RS04055	COG1476	TRANSCRIPTIONal
I2439_RS04075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I2439_RS04080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I2439_RS04085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2439_RS04095	COG1012	belongs to the aldehyde dehydrogenase family
I2439_RS04100	COG0772	Belongs to the SEDS family
I2439_RS04150	COG4708	membrane
I2439_RS04160	COG1597	lipid kinase activity
I2439_RS04165	COG1523	belongs to the glycosyl hydrolase 13 family
I2439_RS04170	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I2439_RS04175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2439_RS04180	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I2439_RS04185	COG0297	glycogen (starch) synthase activity
I2439_RS04190	COG0058	SHG alpha-glucan phosphorylase activity
I2439_RS04270	COG0577	efflux transmembrane transporter activity
I2439_RS04285	COG1309	transcriptional regulator
I2439_RS04340	COG1523	belongs to the glycosyl hydrolase 13 family
I2439_RS04345	COG1595	DNA-templated transcription, initiation
I2439_RS04380	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I2439_RS04390	COG0436	Aminotransferase
I2439_RS04395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2439_RS04405	COG1970	mechanosensitive ion channel activity
I2439_RS04410	COG0358	DNA primase activity
I2439_RS04415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I2439_RS04420	COG2151	metal-sulfur cluster biosynthetic enzyme
I2439_RS04425	COG1091	dTDP-4-dehydrorhamnose reductase activity
I2439_RS04435	COG1215	transferase activity, transferring glycosyl groups
I2439_RS04460	COG0463	Glycosyl transferase, family 2
I2439_RS04480	COG0297	glycogen (starch) synthase activity
I2439_RS04485	COG1368	sulfuric ester hydrolase activity
I2439_RS04490	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2439_RS04540	COG1368	sulfuric ester hydrolase activity
I2439_RS04545	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I2439_RS04550	COG0710	3-dehydroquinate dehydratase activity
I2439_RS04555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I2439_RS04560	COG3679	Belongs to the UPF0342 family
I2439_RS04565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I2439_RS04575	COG1104	cysteine desulfurase activity
I2439_RS04580	COG0301	tRNA thio-modification
I2439_RS04630	COG3561	AntA/AntB antirepressor
I2439_RS04695	COG0582	viral genome integration into host DNA
I2439_RS04830	COG0860	N-Acetylmuramoyl-L-alanine amidase
I2439_RS04830	COG1388	LysM domain
I2439_RS04860	COG1131	(ABC) transporter
I2439_RS04865	COG1725	Transcriptional regulator
I2439_RS04880	COG0469	pyruvate kinase activity
I2439_RS04895	COG2824	Alkylphosphonate utilization operon protein PhnA
I2439_RS04900	COG0765	amino acid transport
I2439_RS04905	COG1126	abc transporter atp-binding protein
I2439_RS04910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2439_RS04915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I2439_RS04920	COG1115	amino acid carrier protein
I2439_RS04970	COG1136	(ABC) transporter
I2439_RS04970	COG4591	ABC-type transport system involved in lipoprotein release permease component
I2439_RS05000	COG0196	riboflavin kinase activity
I2439_RS05015	COG0483	inositol monophosphate 1-phosphatase activity
I2439_RS05020	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I2439_RS05020	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2439_RS05030	COG0573	inorganic phosphate transmembrane transporter activity
I2439_RS05035	COG0581	inorganic phosphate transmembrane transporter activity
I2439_RS05050	COG0704	Plays a role in the regulation of phosphate uptake
I2439_RS05060	COG0745	RESPONSE REGULATOR receiver
I2439_RS05065	COG5002	protein histidine kinase activity
I2439_RS05110	COG1072	(Pantothenic acid kinase))
I2439_RS05115	COG2813	Specifically methylates the guanine in position
I2439_RS05120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I2439_RS05135	COG1744	ABC transporter substrate-binding protein PnrA-like
I2439_RS05140	COG3845	ABC transporter
I2439_RS05145	COG4603	Belongs to the binding-protein-dependent transport system permease family
I2439_RS05150	COG1079	Belongs to the binding-protein-dependent transport system permease family
I2439_RS05155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I2439_RS05160	COG4684	Psort location CytoplasmicMembrane, score
I2439_RS05165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I2439_RS05185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I2439_RS05195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I2439_RS05200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I2439_RS05200	COG1328	CTP reductase activity
I2439_RS05205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I2439_RS05220	COG0488	(ABC) transporter
I2439_RS05230	COG1597	lipid kinase activity
I2439_RS05235	COG1272	protein, Hemolysin III
I2439_RS05255	COG1136	(ABC) transporter
I2439_RS05260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2439_RS05270	COG0758	DNA mediated transformation
I2439_RS05275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I2439_RS05290	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I2439_RS05295	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I2439_RS05300	COG3180	Ammonia monooxygenase
I2439_RS05305	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I2439_RS05315	COG2851	Citrate transporter
I2439_RS05325	COG0511	ligase activity, forming carbon-carbon bonds
I2439_RS05330	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I2439_RS05345	COG3051	citrate lyase alpha subunit
I2439_RS05365	COG1136	(ABC) transporter
I2439_RS05370	COG0577	efflux transmembrane transporter activity
I2439_RS05375	COG0745	RESPONSE REGULATOR receiver
I2439_RS05380	COG5002	protein histidine kinase activity
I2439_RS05385	COG4974	Belongs to the 'phage' integrase family
I2439_RS05395	COG1396	sequence-specific DNA binding
I2439_RS05415	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I2439_RS05470	COG3843	relaxase mobilization nuclease domain protein
I2439_RS05515	COG2188	Transcriptional regulator
I2439_RS05525	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I2439_RS05545	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2439_RS05550	COG0346	lactoylglutathione lyase activity
I2439_RS05555	COG3764	Sortase (surface protein transpeptidase)
I2439_RS05585	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I2439_RS05590	COG1247	-acetyltransferase
I2439_RS05595	COG0009	L-threonylcarbamoyladenylate synthase
I2439_RS05600	COG2890	protein-(glutamine-N5) methyltransferase activity
I2439_RS05615	COG1942	4-Oxalocrotonate Tautomerase
I2439_RS05625	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I2439_RS05635	COG1174	glycine betaine transport
I2439_RS05650	COG4221	oxidoreductase activity
I2439_RS05655	COG0280	phosphate acetyltransferase
I2439_RS05660	COG0564	pseudouridine synthase activity
I2439_RS05670	COG2357	RelA SpoT domain protein
I2439_RS05685	COG1104	cysteine desulfurase activity
I2439_RS05700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I2439_RS05710	COG0628	permease
I2439_RS05730	COG1177	transmembrane transport
I2439_RS05735	COG1176	ABC-type spermidine putrescine transport system, permease component I
I2439_RS05745	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I2439_RS05750	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I2439_RS05765	COG0302	gtp cyclohydrolase
I2439_RS05770	COG0285	dihydrofolate synthase activity
I2439_RS05775	COG0083	homoserine kinase activity
I2439_RS05780	COG0460	homoserine dehydrogenase
I2439_RS05815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I2439_RS05820	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I2439_RS05830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I2439_RS05840	COG3425	synthase
I2439_RS05870	COG1132	(ABC) transporter
I2439_RS05875	COG1132	(ABC) transporter
I2439_RS05880	COG0737	Belongs to the 5'-nucleotidase family
I2439_RS05885	COG0242	peptide deformylase activity
I2439_RS05890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I2439_RS05905	COG0488	(ABC) transporter
I2439_RS05925	COG1388	LysM domain
I2439_RS05925	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2439_RS05945	COG1476	TRANSCRIPTIONal
I2439_RS05950	COG1388	LysM domain
I2439_RS05950	COG1705	Flagellar rod assembly protein muramidase FlgJ
I2439_RS05955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2439_RS05955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I2439_RS05955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2439_RS05960	COG1105	Belongs to the carbohydrate kinase PfkB family
I2439_RS05965	COG1349	DNA-binding transcription factor activity
I2439_RS06005	COG1837	Belongs to the UPF0109 family
I2439_RS06025	COG0577	efflux transmembrane transporter activity
I2439_RS06030	COG1136	(ABC) transporter
I2439_RS06035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I2439_RS06040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I2439_RS06070	COG0564	pseudouridine synthase activity
I2439_RS06085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I2439_RS06135	COG0539	negative regulation of cytoplasmic translation
I2439_RS06155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I2439_RS06170	COG0187	DNA topoisomerase II activity
I2439_RS06195	COG0765	amino acid transport
I2439_RS06215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I2439_RS06230	COG0583	DNA-binding transcription factor activity
I2439_RS06250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I2439_RS06315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2439_RS06335	COG4753	response regulator
I2439_RS06335	COG2207	Transcriptional regulator
I2439_RS06340	COG2972	Histidine kinase
I2439_RS06345	COG3716	PTS system mannose fructose sorbose family IID component
I2439_RS06350	COG3715	PTS system
I2439_RS06435	COG0647	UMP catabolic process
I2439_RS06445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I2439_RS06465	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I2439_RS06470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I2439_RS06475	COG3442	glutamine amidotransferase
I2439_RS06480	COG0095	Lipoate-protein ligase
I2439_RS06490	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2439_RS06495	COG0022	dehydrogenase e1 component
I2439_RS06495	COG0508	dehydrogenase complex catalyzes the overall conversion of
I2439_RS06500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I2439_RS06505	COG0488	(ABC) transporter
I2439_RS06535	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I2439_RS06540	COG0457	Tetratricopeptide repeat
I2439_RS06545	COG0628	permease
I2439_RS06550	COG1051	belongs to the nudix hydrolase family
I2439_RS06555	COG1088	dTDP-glucose 4,6-dehydratase activity
I2439_RS06565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I2439_RS06570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I2439_RS06580	COG2384	SAM-dependent methyltransferase
I2439_RS06585	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I2439_RS06605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I2439_RS06605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I2439_RS06610	COG0300	oxidoreductase activity
I2439_RS06615	COG1234	tRNA 3'-trailer cleavage
I2439_RS06620	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2439_RS06625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I2439_RS06645	COG0058	SHG alpha-glucan phosphorylase activity
I2439_RS06650	COG1640	4-alpha-glucanotransferase
I2439_RS06655	COG1609	Transcriptional regulator
I2439_RS06665	COG1175	transmembrane transport
I2439_RS06670	COG3833	ABC-type maltose transport systems, permease component
I2439_RS06680	COG3833	ABC-type maltose transport systems, permease component
I2439_RS06685	COG1175	transmembrane transport
I2439_RS06695	COG0366	Alpha amylase catalytic
I2439_RS06700	COG2182	Extracellular solute-binding protein
I2439_RS06705	COG0657	acetylesterase activity
I2439_RS06710	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I2439_RS06720	COG1696	Membrane protein involved in D-alanine export
I2439_RS06735	COG0556	nucleotide-excision repair
I2439_RS06740	COG0765	amino acid transport
I2439_RS06745	COG1126	abc transporter atp-binding protein
I2439_RS06755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2439_RS06765	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2439_RS06775	COG3711	transcriptional antiterminator
I2439_RS06775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I2439_RS06785	COG2723	6-phospho-beta-galactosidase activity
I2439_RS06800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I2439_RS06810	COG2309	aminopeptidase activity
I2439_RS06815	COG1187	pseudouridine synthase activity
I2439_RS06825	COG2814	Major facilitator Superfamily
I2439_RS06845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I2439_RS06855	COG5492	domain, Protein
I2439_RS06860	COG0800	Aldolase
I2439_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
I2439_RS06890	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2439_RS06895	COG3715	PTS system
I2439_RS06900	COG3716	PTS system mannose fructose sorbose family IID component
I2439_RS06905	COG1609	Transcriptional regulator
I2439_RS06940	COG1078	dGTPase activity
I2439_RS06980	COG1191	sigma factor activity
I2439_RS07025	COG2814	Major facilitator Superfamily
I2439_RS07040	COG4443	Transcriptional Coactivator p15 (PC4)
I2439_RS07050	COG0826	peptidase U32
I2439_RS07095	COG2183	response to ionizing radiation
I2439_RS07105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I2439_RS07115	COG0573	inorganic phosphate transmembrane transporter activity
I2439_RS07120	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I2439_RS07125	COG5002	protein histidine kinase activity
I2439_RS07130	COG0745	RESPONSE REGULATOR receiver
I2439_RS07140	COG0701	Predicted permease
I2439_RS07145	COG3689	TIGRFAM TIGR03943 family protein
I2439_RS07155	COG1263	PTS System
I2439_RS07155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2439_RS07155	COG2190	(PTS) system
I2439_RS07160	COG3711	transcriptional antiterminator
I2439_RS07165	COG0552	protein localization to endoplasmic reticulum
I2439_RS07170	COG0561	phosphatase activity
I2439_RS07175	COG0561	phosphatase activity
I2439_RS07185	COG1136	(ABC) transporter
I2439_RS07220	COG1196	nuclear chromosome segregation
I2439_RS07225	COG0571	ribonuclease III activity
I2439_RS07245	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I2439_RS07250	COG5002	protein histidine kinase activity
I2439_RS07255	COG0745	RESPONSE REGULATOR receiver
I2439_RS07280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I2439_RS07285	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I2439_RS07290	COG1461	Dihydroxyacetone kinase
I2439_RS07295	COG2376	Dihydroxyacetone kinase
I2439_RS07305	COG2376	Dihydroxyacetone kinase
I2439_RS07320	COG4555	ABC transporter
I2439_RS07355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I2439_RS07360	COG0438	transferase activity, transferring glycosyl groups
I2439_RS07375	COG1609	Transcriptional regulator
I2439_RS07380	COG0006	proline dipeptidase activity
I2439_RS07390	COG0463	Glycosyl transferase, family 2
I2439_RS07395	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I2439_RS07400	COG0557	exoribonuclease II activity
I2439_RS07410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2439_RS07445	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2439_RS07450	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2439_RS07455	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2439_RS07470	COG1940	carbohydrate kinase activity
I2439_RS07480	COG2610	gluconate transmembrane transporter activity
I2439_RS07485	COG1028	Short-chain dehydrogenase reductase Sdr
I2439_RS07495	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I2439_RS07500	COG0183	Belongs to the thiolase family
I2439_RS07505	COG0583	DNA-binding transcription factor activity
I2439_RS07515	COG1131	(ABC) transporter
I2439_RS07530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I2439_RS07545	COG1573	uracil-dna glycosylase
I2439_RS07550	COG1702	phosphate starvation-inducible protein PhoH
I2439_RS07585	COG0444	Belongs to the ABC transporter superfamily
I2439_RS07590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2439_RS07595	COG0601	transmembrane transport
I2439_RS07600	COG0747	negative chemotaxis
I2439_RS07670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I2439_RS07690	COG0673	inositol 2-dehydrogenase activity
I2439_RS07700	COG1028	Short-chain dehydrogenase reductase Sdr
I2439_RS07710	COG0582	viral genome integration into host DNA
I2439_RS07825	COG1376	ErfK ybiS ycfS ynhG family protein
I2439_RS07840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I2439_RS07865	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I2439_RS07865	COG1605	Chorismate mutase
I2439_RS07870	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I2439_RS07885	COG3250	beta-galactosidase activity
I2439_RS07890	COG4753	response regulator
I2439_RS07890	COG2207	Transcriptional regulator
I2439_RS07895	COG2972	Histidine kinase
I2439_RS07905	COG1653	transport
I2439_RS07910	COG0395	ABC-type sugar transport system, permease component
I2439_RS07915	COG1175	transmembrane transport
I2439_RS07920	COG1940	carbohydrate kinase activity
I2439_RS07930	COG2723	6-phospho-beta-galactosidase activity
I2439_RS07935	COG3291	Pkd domain containing protein
I2439_RS07935	COG3525	Glycosyl hydrolase, family 20, catalytic domain
I2439_RS07950	COG0383	alpha-mannosidase activity
I2439_RS07955	COG1136	(ABC) transporter
I2439_RS08000	COG2274	protein secretion by the type I secretion system
I2439_RS08015	COG3290	protein histidine kinase activity
I2439_RS08040	COG1486	melibiose metabolic process
I2439_RS08045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2439_RS08045	COG1263	PTS System
I2439_RS08150	COG1040	competence protein
I2439_RS08155	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I2439_RS08160	COG1739	Uncharacterized protein family UPF0029
I2439_RS08170	COG1098	S1 RNA binding domain
I2439_RS08180	COG2197	response regulator
I2439_RS08185	COG4585	Histidine kinase
I2439_RS08195	COG2815	serine threonine protein kinase
I2439_RS08195	COG0515	serine threonine protein kinase
I2439_RS08205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I2439_RS08205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I2439_RS08210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I2439_RS08215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I2439_RS08235	COG1854	S-ribosylhomocysteine lyase activity
I2439_RS08245	COG0116	Belongs to the methyltransferase superfamily
I2439_RS08270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I2439_RS08275	COG3579	cysteine-type endopeptidase activity
I2439_RS08285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I2439_RS08290	COG1113	amino acid transport
I2439_RS08295	COG0492	ferredoxin-NADP+ reductase activity
I2439_RS08305	COG1126	abc transporter atp-binding protein
I2439_RS08325	COG0513	Belongs to the DEAD box helicase family
I2439_RS08335	COG0768	penicillin binding
I2439_RS08375	COG1131	(ABC) transporter
I2439_RS08395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I2439_RS08430	COG1774	PSP1 C-terminal conserved region
I2439_RS08435	COG0470	DNA polymerase III
I2439_RS08440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I2439_RS08465	COG2244	polysaccharide biosynthetic process
I2439_RS08475	COG1120	ATPase activity
I2439_RS08480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I2439_RS08485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2439_RS08490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I2439_RS08505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2439_RS08510	COG1253	flavin adenine dinucleotide binding
I2439_RS08515	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I2439_RS08525	COG1242	4 iron, 4 sulfur cluster binding
I2439_RS08530	COG0671	phosphoesterase, PA-phosphatase related
I2439_RS08535	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I2439_RS08595	COG1187	pseudouridine synthase activity
I2439_RS08610	COG0582	viral genome integration into host DNA
I2439_RS08650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2439_RS08655	COG1254	Belongs to the acylphosphatase family
I2439_RS08670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I2439_RS08680	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I2439_RS08700	COG1484	DNA-dependent DNA replication
I2439_RS08720	COG0745	RESPONSE REGULATOR receiver
I2439_RS08735	COG1704	LemA family
I2439_RS08745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I2439_RS08750	COG0569	domain protein
I2439_RS08760	COG1114	Component of the transport system for branched-chain amino acids
I2439_RS08775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I2439_RS08780	COG1464	Belongs to the NlpA lipoprotein family
I2439_RS08785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I2439_RS08795	COG0789	Transcriptional regulator
I2439_RS08805	COG2226	methyltransferase
I2439_RS08810	COG0799	negative regulation of ribosome biogenesis
I2439_RS08815	COG1713	HD superfamily hydrolase involved in NAD metabolism
I2439_RS08820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I2439_RS08825	COG1534	Rna-binding protein
I2439_RS08830	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I2439_RS08835	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I2439_RS08880	COG0444	Belongs to the ABC transporter superfamily
I2439_RS08885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I2439_RS08890	COG0601	transmembrane transport
I2439_RS08895	COG4166	transmembrane transport
I2439_RS08900	COG1686	Belongs to the peptidase S11 family
I2439_RS08905	COG1686	Belongs to the peptidase S11 family
I2439_RS08915	COG0719	Fe-S assembly protein
I2439_RS08925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I2439_RS08930	COG0719	Fe-S assembly protein
I2439_RS08940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I2439_RS08955	COG0765	amino acid transport
I2439_RS08960	COG1126	abc transporter atp-binding protein
I2439_RS09000	COG0191	fructose-bisphosphate aldolase activity
I2439_RS09015	COG0504	CTP synthase activity
I2439_RS09030	COG0366	Alpha amylase catalytic
I2439_RS09035	COG0668	transmembrane transport
I2439_RS09045	COG4720	Psort location CytoplasmicMembrane, score
I2439_RS09050	COG0352	thiamine-phosphate diphosphorylase activity
I2439_RS09050	COG0351	phosphomethylpyrimidine kinase
I2439_RS09060	COG0527	aspartate kinase activity
I2439_RS09175	COG0803	Belongs to the bacterial solute-binding protein 9 family
I2439_RS09185	COG1597	lipid kinase activity
I2439_RS09190	COG1609	Transcriptional regulator
I2439_RS09195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I2439_RS09200	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I2439_RS09205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I2439_RS09210	COG2017	converts alpha-aldose to the beta-anomer
I2439_RS09230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I2439_RS09235	COG0732	type I restriction modification DNA specificity domain
I2439_RS09240	COG0732	type I restriction modification DNA specificity domain
I2439_RS09245	COG4974	Belongs to the 'phage' integrase family
I2439_RS09255	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I2439_RS09295	COG0582	viral genome integration into host DNA
I2439_RS09315	COG1674	ftsk spoiiie
I2439_RS09345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I2439_RS09360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I2439_RS09370	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I2439_RS09380	COG1045	serine acetyltransferase
I2439_RS09410	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I2439_RS09415	COG1846	Transcriptional regulator
I2439_RS09430	COG0442	prolyl-tRNA aminoacylation
I2439_RS09440	COG4589	Belongs to the CDS family
I2439_RS09450	COG1862	Preprotein translocase
I2439_RS09465	COG3842	ATPase activity
I2439_RS09510	COG1263	PTS System
I2439_RS09510	COG2190	(PTS) system
I2439_RS09510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I2439_RS09515	COG1609	Transcriptional regulator
I2439_RS09520	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I2439_RS09525	COG2264	protein methyltransferase activity
I2439_RS09550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I2439_RS09555	COG0512	Glutamine amidotransferase of anthranilate synthase
I2439_RS09560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I2439_RS09650	COG1882	Formate acetyltransferase
I2439_RS09655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2439_RS09660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I2439_RS09665	COG1447	Phosphotransferase system cellobiose-specific component IIA
I2439_RS09675	COG1349	DNA-binding transcription factor activity
I2439_RS09680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I2439_RS09740	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I2439_RS09745	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I2439_RS09750	COG1428	Deoxynucleoside kinase
I2439_RS09765	COG4120	Belongs to the binding-protein-dependent transport system permease family
I2439_RS09790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I2439_RS09795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I2439_RS09805	COG1363	Peptidase, m42
I2439_RS09810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I2439_RS09840	COG0602	queuosine metabolic process
I2439_RS09860	COG1328	CTP reductase activity
I2439_RS09875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I2439_RS09885	COG1393	Belongs to the ArsC family
I2439_RS09895	COG1546	Belongs to the CinA family
I2439_RS09895	COG1058	Belongs to the CinA family
I2439_RS09915	COG0519	Catalyzes the synthesis of GMP from XMP
I2439_RS09920	COG0632	four-way junction helicase activity
I2439_RS09925	COG2814	Major facilitator Superfamily
I2439_RS09945	COG1438	arginine binding
I2439_RS09950	COG0018	arginyl-trna synthetase
I2439_RS09955	COG0488	(ABC) transporter
I2439_RS09960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2439_RS09965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2439_RS09970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2439_RS09975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I2439_RS09985	COG1131	(ABC) transporter
I2439_RS10005	COG0124	histidyl-tRNA synthetase
I2439_RS10015	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I2439_RS10020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I2439_RS10045	COG2197	response regulator
I2439_RS10060	COG1136	(ABC) transporter
I2439_RS10060	COG0577	efflux transmembrane transporter activity
I2439_RS10080	COG0494	nUDIX hydrolase
I2439_RS10100	COG1511	domain protein
I2439_RS10140	COG0305	Participates in initiation and elongation during chromosome replication
I2439_RS10170	COG1760	l-serine dehydratase
I2439_RS10175	COG1760	l-serine dehydratase
I2439_RS10205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I2439_RS10215	COG0612	Peptidase, M16
I2439_RS10225	COG2501	S4 domain
I2439_RS10260	COG0516	GMP reductase activity
I2439_RS10260	COG0517	IMP dehydrogenase activity
I2439_RS10270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I2439_RS10275	COG0488	(ABC) transporter
I2439_RS10305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I2439_RS10310	COG1475	DNA binding