locus-tag	class	description
A6J85_RS00010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J85_RS00015	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A6J85_RS00025	COG1268	BioY protein
A6J85_RS00030	COG4443	Transcriptional Coactivator p15 (PC4)
A6J85_RS00040	COG0826	peptidase U32
A6J85_RS00070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6J85_RS00075	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A6J85_RS00080	COG1051	belongs to the nudix hydrolase family
A6J85_RS00085	COG1983	PspC domain protein
A6J85_RS00090	COG2514	catechol 2,3-dioxygenase activity
A6J85_RS00095	COG1959	2 iron, 2 sulfur cluster binding
A6J85_RS00110	COG0577	efflux transmembrane transporter activity
A6J85_RS00110	COG1136	(ABC) transporter
A6J85_RS00115	COG1309	transcriptional regulator
A6J85_RS00140	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J85_RS00145	COG0557	exoribonuclease II activity
A6J85_RS00155	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J85_RS00160	COG2814	Major facilitator Superfamily
A6J85_RS00165	COG0237	dephospho-CoA kinase activity
A6J85_RS00170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6J85_RS00185	COG3177	Filamentation induced by cAMP protein fic
A6J85_RS00205	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A6J85_RS00210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6J85_RS00215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J85_RS00220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6J85_RS00230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J85_RS00235	COG0686	Belongs to the AlaDH PNT family
A6J85_RS00245	COG1702	phosphate starvation-inducible protein PhoH
A6J85_RS00250	COG4479	Belongs to the UPF0346 family
A6J85_RS00255	COG0588	phosphoglycerate mutase activity
A6J85_RS00260	COG0735	belongs to the Fur family
A6J85_RS00270	COG1307	EDD domain protein, DegV family
A6J85_RS00275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6J85_RS00280	COG0497	DNA recombination
A6J85_RS00285	COG1438	arginine binding
A6J85_RS00290	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6J85_RS00300	COG1722	exodeoxyribonuclease VII activity
A6J85_RS00305	COG1570	exodeoxyribonuclease VII activity
A6J85_RS00325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6J85_RS00330	COG4703	Protein of unknown function (DUF1797)
A6J85_RS00335	COG0542	response to heat
A6J85_RS00345	COG2378	regulation of single-species biofilm formation
A6J85_RS00370	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J85_RS00375	COG3599	regulation of cell shape
A6J85_RS00380	COG2302	S4 RNA-binding domain
A6J85_RS00390	COG1799	cell septum assembly
A6J85_RS00395	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J85_RS00410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6J85_RS00415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6J85_RS00420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6J85_RS00430	COG1217	gtp-binding protein TYPA
A6J85_RS00435	COG1187	pseudouridine synthase activity
A6J85_RS00440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J85_RS00470	COG0159	tryptophan synthase activity
A6J85_RS00480	COG0135	phosphoribosylanthranilate isomerase activity
A6J85_RS00485	COG0134	indole-3-glycerol-phosphate synthase activity
A6J85_RS00490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6J85_RS00495	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J85_RS00500	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J85_RS00510	COG0133	tryptophan synthase activity
A6J85_RS00520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J85_RS00525	COG4470	Protein conserved in bacteria
A6J85_RS00530	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6J85_RS00535	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6J85_RS00540	COG0742	ribosomal rna small subunit methyltransferase
A6J85_RS00550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6J85_RS00555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J85_RS00585	COG0525	valine-tRNA ligase activity
A6J85_RS00595	COG0519	Catalyzes the synthesis of GMP from XMP
A6J85_RS00620	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6J85_RS00625	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6J85_RS00630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J85_RS00635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J85_RS00645	COG2137	regulation of response to DNA damage stimulus
A6J85_RS00730	COG1040	competence protein
A6J85_RS00735	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A6J85_RS00740	COG1739	Uncharacterized protein family UPF0029
A6J85_RS00750	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J85_RS00765	COG4585	Histidine kinase
A6J85_RS00775	COG0515	serine threonine protein kinase
A6J85_RS00775	COG2815	serine threonine protein kinase
A6J85_RS00780	COG0631	protein serine/threonine phosphatase activity
A6J85_RS00785	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J85_RS00785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J85_RS00790	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J85_RS00795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J85_RS00800	COG1758	RNA polymerase activity
A6J85_RS00810	COG1418	mRNA catabolic process
A6J85_RS00815	COG1854	S-ribosylhomocysteine lyase activity
A6J85_RS00825	COG0116	Belongs to the methyltransferase superfamily
A6J85_RS00835	COG3599	regulation of cell shape
A6J85_RS00840	COG4474	Belongs to the UPF0398 family
A6J85_RS00845	COG3331	DNA recombination
A6J85_RS00850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J85_RS00855	COG3579	cysteine-type endopeptidase activity
A6J85_RS00860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J85_RS00865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J85_RS00870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J85_RS00875	COG0492	ferredoxin-NADP+ reductase activity
A6J85_RS00885	COG1126	abc transporter atp-binding protein
A6J85_RS00895	COG0513	Belongs to the DEAD box helicase family
A6J85_RS00900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J85_RS00905	COG0768	penicillin binding
A6J85_RS00915	COG0275	rRNA processing
A6J85_RS00930	COG4224	UPF0291 protein
A6J85_RS00935	COG0751	glycine-tRNA ligase activity
A6J85_RS00950	COG1064	alcohol dehydrogenase
A6J85_RS01005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6J85_RS01015	COG0656	L-ascorbic acid biosynthetic process
A6J85_RS01030	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6J85_RS01035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6J85_RS01040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6J85_RS01050	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6J85_RS01060	COG0779	Required for maturation of 30S ribosomal subunits
A6J85_RS01065	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J85_RS01080	COG1131	(ABC) transporter
A6J85_RS01085	COG0537	adenosine 5'-monophosphoramidase activity
A6J85_RS01095	COG1316	TRANSCRIPTIONal
A6J85_RS01105	COG0802	atpase or kinase
A6J85_RS01110	COG2252	PERMEase
A6J85_RS01120	COG0561	phosphatase activity
A6J85_RS01125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J85_RS01130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6J85_RS01135	COG0440	acetolactate synthase activity
A6J85_RS01140	COG0028	Belongs to the TPP enzyme family
A6J85_RS01155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J85_RS01160	COG1254	Belongs to the acylphosphatase family
A6J85_RS01175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6J85_RS01180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J85_RS01190	COG0456	acetyltransferase
A6J85_RS01195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J85_RS01210	COG1160	GTP binding
A6J85_RS01220	COG1160	GTP binding
A6J85_RS01230	COG1484	DNA-dependent DNA replication
A6J85_RS01240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6J85_RS01255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J85_RS01255	COG1263	PTS System
A6J85_RS01255	COG2190	(PTS) system
A6J85_RS01260	COG0745	RESPONSE REGULATOR receiver
A6J85_RS01270	COG2268	Band 7 protein
A6J85_RS01280	COG1396	sequence-specific DNA binding
A6J85_RS01295	COG1396	sequence-specific DNA binding
A6J85_RS01300	COG0501	Belongs to the peptidase M48B family
A6J85_RS01305	COG1704	LemA family
A6J85_RS01310	COG1309	transcriptional regulator
A6J85_RS01320	COG0357	Ribosomal RNA small subunit methyltransferase G
A6J85_RS01335	COG1122	ATPase activity
A6J85_RS01350	COG0745	RESPONSE REGULATOR receiver
A6J85_RS01395	COG1054	Belongs to the UPF0176 family
A6J85_RS01430	COG4720	Psort location CytoplasmicMembrane, score
A6J85_RS01440	COG1129	ABC transporter
A6J85_RS01455	COG1132	(ABC) transporter
A6J85_RS01470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J85_RS01475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J85_RS01480	COG1464	Belongs to the NlpA lipoprotein family
A6J85_RS01485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J85_RS01490	COG1473	amidohydrolase
A6J85_RS01500	COG0217	transcriptional regulatory protein
A6J85_RS01510	COG1323	Belongs to the UPF0348 family
A6J85_RS01515	COG2226	methyltransferase
A6J85_RS01520	COG0799	negative regulation of ribosome biogenesis
A6J85_RS01525	COG1713	HD superfamily hydrolase involved in NAD metabolism
A6J85_RS01530	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6J85_RS01535	COG1534	Rna-binding protein
A6J85_RS01540	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J85_RS01545	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A6J85_RS01560	COG0697	spore germination
A6J85_RS01575	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6J85_RS01580	COG0154	amidase activity
A6J85_RS01585	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6J85_RS01590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6J85_RS01595	COG1335	isochorismatase
A6J85_RS01600	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A6J85_RS01610	COG0436	Aminotransferase
A6J85_RS01615	COG0589	response to stress
A6J85_RS01620	COG0561	phosphatase activity
A6J85_RS01625	COG0252	asparaginase activity
A6J85_RS01630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J85_RS01635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J85_RS01640	COG0736	holo-[acyl-carrier-protein] synthase activity
A6J85_RS01645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J85_RS01660	COG3343	RNA polymerase activity
A6J85_RS01665	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6J85_RS01670	COG4475	Protein of unknown function (DUF436)
A6J85_RS01675	COG4720	Psort location CytoplasmicMembrane, score
A6J85_RS01680	COG0351	phosphomethylpyrimidine kinase
A6J85_RS01685	COG3064	Membrane
A6J85_RS01690	COG0101	tRNA pseudouridine synthase activity
A6J85_RS01700	COG3064	Membrane
A6J85_RS01700	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6J85_RS01700	COG3583	domain protein
A6J85_RS01705	COG0484	heat shock protein binding
A6J85_RS01725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6J85_RS01730	COG1420	regulation of RNA biosynthetic process
A6J85_RS01765	COG1876	peptidase activity
A6J85_RS01770	COG0588	phosphoglycerate mutase activity
A6J85_RS01780	COG2848	UPF0210 protein
A6J85_RS01785	COG3830	Belongs to the UPF0237 family
A6J85_RS01795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6J85_RS01800	COG0789	Transcriptional regulator
A6J85_RS01800	COG4978	Transcriptional regulator
A6J85_RS01805	COG3583	domain protein
A6J85_RS01805	COG1621	beta-fructofuranosidase activity
A6J85_RS01805	COG5492	domain, Protein
A6J85_RS01815	COG1301	dicarboxylic acid transport
A6J85_RS01820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J85_RS01835	COG2323	membrane
A6J85_RS01840	COG3237	CsbD-like
A6J85_RS01900	COG3290	protein histidine kinase activity
A6J85_RS01930	COG0542	response to heat
A6J85_RS01935	COG1396	sequence-specific DNA binding
A6J85_RS01945	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6J85_RS01970	COG2217	Heavy metal translocating P-type atpase
A6J85_RS01980	COG3328	transposase activity
A6J85_RS01995	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6J85_RS02070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6J85_RS02075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J85_RS02090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J85_RS02100	COG0531	amino acid
A6J85_RS02105	COG3842	ATPase activity
A6J85_RS02115	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A6J85_RS02120	COG0215	cysteine-tRNA ligase activity
A6J85_RS02140	COG1045	serine acetyltransferase
A6J85_RS02150	COG0477	Major facilitator Superfamily
A6J85_RS02155	COG1164	Oligoendopeptidase f
A6J85_RS02170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J85_RS02175	COG3118	belongs to the thioredoxin family
A6J85_RS02190	COG2267	carboxylic ester hydrolase activity
A6J85_RS02245	COG1187	pseudouridine synthase activity
A6J85_RS02255	COG0242	peptide deformylase activity
A6J85_RS02275	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6J85_RS02275	COG1404	Belongs to the peptidase S8 family
A6J85_RS02285	COG0406	alpha-ribazole phosphatase activity
A6J85_RS02310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6J85_RS02325	COG1131	(ABC) transporter
A6J85_RS02350	COG1131	(ABC) transporter
A6J85_RS02370	COG5002	protein histidine kinase activity
A6J85_RS02370	COG3850	Histidine kinase
A6J85_RS02375	COG0745	RESPONSE REGULATOR receiver
A6J85_RS02380	COG2723	6-phospho-beta-galactosidase activity
A6J85_RS02390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6J85_RS02400	COG0028	Belongs to the TPP enzyme family
A6J85_RS02430	COG0561	phosphatase activity
A6J85_RS02435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6J85_RS02445	COG2207	Transcriptional regulator
A6J85_RS02445	COG1917	Cupin 2, conserved barrel domain protein
A6J85_RS02465	COG1263	PTS System
A6J85_RS02465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J85_RS02465	COG2190	(PTS) system
A6J85_RS02480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J85_RS02480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J85_RS02485	COG0167	dihydroorotate dehydrogenase activity
A6J85_RS02490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J85_RS02515	COG5504	Zn-dependent protease
A6J85_RS02525	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6J85_RS02535	COG0668	transmembrane transport
A6J85_RS02540	COG0531	amino acid
A6J85_RS02550	COG0583	DNA-binding transcription factor activity
A6J85_RS02560	COG3118	belongs to the thioredoxin family
A6J85_RS02575	COG1193	negative regulation of DNA recombination
A6J85_RS02590	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J85_RS02595	COG0681	Belongs to the peptidase S26 family
A6J85_RS02600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J85_RS02605	COG1309	transcriptional regulator
A6J85_RS02635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J85_RS02640	COG1882	Formate acetyltransferase
A6J85_RS02655	COG3425	synthase
A6J85_RS02665	COG1304	FMN binding
A6J85_RS02685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6J85_RS02700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J85_RS02720	COG0584	glycerophosphoryl diester phosphodiesterase
A6J85_RS02730	COG2081	HI0933 family
A6J85_RS02735	COG0789	Transcriptional regulator
A6J85_RS02745	COG2226	methyltransferase
A6J85_RS02760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6J85_RS02770	COG1214	PFAM Peptidase M22, glycoprotease
A6J85_RS02775	COG5503	Protein of unknown function (DUF1447)
A6J85_RS02790	COG1914	H( )-stimulated, divalent metal cation uptake system
A6J85_RS02800	COG0174	glutamine synthetase
A6J85_RS02805	COG0789	Transcriptional regulator
A6J85_RS02815	COG3942	CHAP domain
A6J85_RS02825	COG0126	phosphoglycerate kinase activity
A6J85_RS02840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J85_RS02845	COG0049	tRNA binding
A6J85_RS02850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6J85_RS02865	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J85_RS02870	COG3481	metal-dependent phosphohydrolase, HD sub domain
A6J85_RS02880	COG1564	THIamine pyrophosphokinase
A6J85_RS02890	COG1162	GTPase activity
A6J85_RS02910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J85_RS02935	COG0084	hydrolase, TatD family'
A6J85_RS02945	COG3655	Transcriptional regulator
A6J85_RS02955	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6J85_RS02970	COG1847	R3H domain protein
A6J85_RS02980	COG0594	ribonuclease P activity
A6J85_RS02990	COG0165	Argininosuccinate lyase
A6J85_RS02995	COG0137	argininosuccinate synthase activity
A6J85_RS03000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J85_RS03020	COG0756	dUTP diphosphatase activity
A6J85_RS03030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6J85_RS03035	COG1132	(ABC) transporter
A6J85_RS03040	COG1132	(ABC) transporter
A6J85_RS03045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6J85_RS03050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6J85_RS03065	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J85_RS03075	COG2171	N-acyltransferase activity
A6J85_RS03095	COG0166	Belongs to the GPI family
A6J85_RS03120	COG0343	queuine tRNA-ribosyltransferase activity
A6J85_RS03150	COG1832	CoA-binding protein
A6J85_RS03155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J85_RS03155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J85_RS03165	COG0546	phosphoglycolate phosphatase activity
A6J85_RS03185	COG1394	ATPase activity, coupled to movement of substances
A6J85_RS03190	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A6J85_RS03195	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A6J85_RS03205	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A6J85_RS03210	COG1527	subunit (C
A6J85_RS03220	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J85_RS03225	COG1269	ATP hydrolysis coupled proton transport
A6J85_RS03250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J85_RS03255	COG0673	inositol 2-dehydrogenase activity
A6J85_RS03270	COG1653	transport
A6J85_RS03275	COG2731	YhcH YjgK YiaL family protein
A6J85_RS03280	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A6J85_RS03285	COG1454	alcohol dehydrogenase
A6J85_RS03285	COG1012	belongs to the aldehyde dehydrogenase family
A6J85_RS03290	COG2755	lipolytic protein G-D-S-L family
A6J85_RS03290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A6J85_RS03300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J85_RS03310	COG2255	four-way junction helicase activity
A6J85_RS03320	COG0058	SHG alpha-glucan phosphorylase activity
A6J85_RS03325	COG1640	4-alpha-glucanotransferase
A6J85_RS03335	COG2182	Extracellular solute-binding protein
A6J85_RS03340	COG1175	transmembrane transport
A6J85_RS03345	COG3833	ABC-type maltose transport systems, permease component
A6J85_RS03355	COG1609	Transcriptional regulator
A6J85_RS03360	COG1523	belongs to the glycosyl hydrolase 13 family
A6J85_RS03365	COG1780	Probably involved in ribonucleotide reductase function
A6J85_RS03375	COG1011	Hydrolase
A6J85_RS03380	COG1619	proteins homologs of microcin C7 resistance protein MccF
A6J85_RS03410	COG1230	cation diffusion facilitator family transporter
A6J85_RS03430	COG1349	DNA-binding transcription factor activity
A6J85_RS03515	COG4499	WXG100 protein secretion system (Wss), protein YukC
A6J85_RS03545	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6J85_RS03550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J85_RS03555	COG1696	Membrane protein involved in D-alanine export
A6J85_RS03590	COG2222	sugar isomerase
A6J85_RS03600	COG3716	PTS system mannose fructose sorbose family IID component
A6J85_RS03610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J85_RS03625	COG0138	bifunctional purine biosynthesis protein purh
A6J85_RS03635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J85_RS03640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6J85_RS03650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J85_RS03660	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J85_RS03665	COG0416	fatty acid biosynthetic process
A6J85_RS03670	COG1381	Involved in DNA repair and RecF pathway recombination
A6J85_RS03675	COG0436	Aminotransferase
A6J85_RS03685	COG0305	Participates in initiation and elongation during chromosome replication
A6J85_RS03690	COG0359	binds to the 23S rRNA
A6J85_RS03700	COG0445	tRNA wobble uridine modification
A6J85_RS03705	COG0482	sulfurtransferase activity
A6J85_RS03715	COG1760	l-serine dehydratase
A6J85_RS03720	COG1760	l-serine dehydratase
A6J85_RS03725	COG0741	lytic transglycosylase activity
A6J85_RS03730	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A6J85_RS03735	COG1122	ATPase activity
A6J85_RS03740	COG1122	ATPase activity
A6J85_RS03745	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J85_RS03755	COG0612	Peptidase, M16
A6J85_RS03760	COG0612	Peptidase, M16
A6J85_RS03770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6J85_RS03775	COG0516	GMP reductase activity
A6J85_RS03775	COG0517	IMP dehydrogenase activity
A6J85_RS03780	COG0180	Tryptophanyl-tRNA synthetase
A6J85_RS03785	COG0488	(ABC) transporter
A6J85_RS03805	COG0592	DNA-directed DNA polymerase activity
A6J85_RS03815	COG1475	DNA binding
A6J85_RS03820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J85_RS03825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6J85_RS03860	COG0012	GTP binding
A6J85_RS03865	COG0193	aminoacyl-tRNA hydrolase activity
A6J85_RS03870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J85_RS03875	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J85_RS03895	COG0037	tRNA processing
A6J85_RS03900	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6J85_RS03905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J85_RS04030	COG1792	Involved in formation and maintenance of cell shape
A6J85_RS04040	COG3942	CHAP domain
A6J85_RS04045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J85_RS04070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6J85_RS04075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6J85_RS04085	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6J85_RS04090	COG2274	protein secretion by the type I secretion system
A6J85_RS04095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J85_RS04105	COG0151	Belongs to the GarS family
A6J85_RS04115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J85_RS04120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6J85_RS04140	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J85_RS04145	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J85_RS04175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J85_RS04180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6J85_RS04185	COG0129	dihydroxy-acid dehydratase activity
A6J85_RS04190	COG2151	metal-sulfur cluster biosynthetic enzyme
A6J85_RS04195	COG0124	histidyl-tRNA synthetase
A6J85_RS04210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J85_RS04215	COG0018	arginyl-trna synthetase
A6J85_RS04220	COG1438	arginine binding
A6J85_RS04225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6J85_RS04240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6J85_RS04250	COG1395	domain, Protein
A6J85_RS04255	COG0632	four-way junction helicase activity
A6J85_RS04260	COG2818	Glycosylase
A6J85_RS04275	COG1546	Belongs to the CinA family
A6J85_RS04275	COG1058	Belongs to the CinA family
A6J85_RS04280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6J85_RS04285	COG1393	Belongs to the ArsC family
A6J85_RS04295	COG4472	Bacterial protein of unknown function (DUF965)
A6J85_RS04300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6J85_RS04305	COG3906	Belongs to the UPF0473 family
A6J85_RS04310	COG0285	dihydrofolate synthase activity
A6J85_RS04320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J85_RS04330	COG1328	CTP reductase activity
A6J85_RS04350	COG0602	queuosine metabolic process
A6J85_RS04365	COG3944	biosynthesis protein
A6J85_RS04370	COG0489	protein tyrosine kinase activity
A6J85_RS04385	COG0297	glycogen (starch) synthase activity
A6J85_RS04395	COG1216	Glycosyl transferase, family 2
A6J85_RS04395	COG1442	glycosyl transferase family 8
A6J85_RS04410	COG0562	UDP-galactopyranose mutase
A6J85_RS04415	COG0438	transferase activity, transferring glycosyl groups
A6J85_RS04430	COG0564	pseudouridine synthase activity
A6J85_RS04435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J85_RS04440	COG2321	neutral zinc metallopeptidase
A6J85_RS04445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J85_RS04460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J85_RS04480	COG0052	Belongs to the universal ribosomal protein uS2 family
A6J85_RS04485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J85_RS04495	COG4463	regulation of RNA biosynthetic process
A6J85_RS04510	COG3201	nicotinamide mononucleotide transporter
A6J85_RS04525	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J85_RS04530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6J85_RS04535	COG2918	glutathione biosynthetic process
A6J85_RS04535	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J85_RS04540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J85_RS04550	COG0051	transcription antitermination factor activity, RNA binding
A6J85_RS04555	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6J85_RS04560	COG0088	Forms part of the polypeptide exit tunnel
A6J85_RS04565	COG0089	rRNA binding
A6J85_RS04570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6J85_RS04575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6J85_RS04580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6J85_RS04585	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6J85_RS04590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6J85_RS04595	COG0255	Belongs to the universal ribosomal protein uL29 family
A6J85_RS04600	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6J85_RS04605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6J85_RS04610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6J85_RS04615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6J85_RS04620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6J85_RS04625	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6J85_RS04630	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6J85_RS04640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6J85_RS04645	COG1841	ribosomal large subunit assembly
A6J85_RS04650	COG0200	Binds to the 23S rRNA
A6J85_RS04655	COG0201	protein transport
A6J85_RS04660	COG0563	adenylate kinase activity
A6J85_RS04665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6J85_RS04670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J85_RS04675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6J85_RS04680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6J85_RS04685	COG0202	RNA polymerase activity
A6J85_RS04690	COG0203	ribosomal protein L17
A6J85_RS04780	COG1846	Transcriptional regulator
A6J85_RS04785	COG1121	(ABC) transporter
A6J85_RS04790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J85_RS04795	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J85_RS04795	COG3443	Belongs to the bacterial solute-binding protein 9 family
A6J85_RS04825	COG0500	methyltransferase
A6J85_RS04830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J85_RS04845	COG0085	RNA polymerase activity
A6J85_RS04850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6J85_RS04860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J85_RS04870	COG4537	Required for transformation and DNA binding
A6J85_RS04910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6J85_RS04925	COG1131	(ABC) transporter
A6J85_RS04960	COG4868	Belongs to the UPF0371 family
A6J85_RS04970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J85_RS04975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J85_RS04985	COG1363	Peptidase, m42
A6J85_RS04995	COG4585	Histidine kinase
A6J85_RS05000	COG2197	response regulator
A6J85_RS05025	COG3716	PTS system mannose fructose sorbose family IID component
A6J85_RS05035	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6J85_RS05065	COG0302	gtp cyclohydrolase
A6J85_RS05070	COG0360	Binds together with S18 to 16S ribosomal RNA
A6J85_RS05075	COG0629	single-stranded DNA binding
A6J85_RS05080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6J85_RS05085	COG1309	transcriptional regulator
A6J85_RS05090	COG1131	(ABC) transporter
A6J85_RS05145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J85_RS05150	COG0006	proline dipeptidase activity
A6J85_RS05165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J85_RS05175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J85_RS05180	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6J85_RS05185	COG1609	Transcriptional regulator
A6J85_RS05190	COG1621	beta-fructofuranosidase activity
A6J85_RS05200	COG2190	(PTS) system
A6J85_RS05200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J85_RS05200	COG1263	PTS System
A6J85_RS05215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6J85_RS05220	COG4589	Belongs to the CDS family
A6J85_RS05225	COG0750	zinc metalloprotease
A6J85_RS05230	COG0442	prolyl-tRNA aminoacylation
A6J85_RS05275	COG0464	growth
A6J85_RS05280	COG2309	aminopeptidase activity
A6J85_RS05290	COG2261	transglycosylase associated protein
A6J85_RS05315	COG1609	Transcriptional regulator
A6J85_RS05320	COG0561	phosphatase activity
A6J85_RS05330	COG3237	CsbD-like
A6J85_RS05350	COG2261	transglycosylase associated protein
A6J85_RS05355	COG3711	transcriptional antiterminator
A6J85_RS05390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J85_RS05415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J85_RS05420	COG1396	sequence-specific DNA binding
A6J85_RS05435	COG1490	D-aminoacyl-tRNA deacylase activity
A6J85_RS05450	COG1673	EVE domain
A6J85_RS05455	COG1846	Transcriptional regulator
A6J85_RS05475	COG0010	Belongs to the arginase family
A6J85_RS05485	COG2986	histidine ammonia-lyase
A6J85_RS05490	COG0531	amino acid
A6J85_RS05500	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6J85_RS05505	COG3404	Formiminotransferase-cyclodeaminase
A6J85_RS05515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A6J85_RS05520	COG1228	amidohydrolase
A6J85_RS05545	COG3590	peptidase
A6J85_RS05575	COG0495	leucyl-tRNA aminoacylation
A6J85_RS05630	COG1063	alcohol dehydrogenase
A6J85_RS05650	COG3537	Alpha-1,2-mannosidase
A6J85_RS05680	COG4209	transmembrane transport
A6J85_RS05685	COG0395	ABC-type sugar transport system, permease component
A6J85_RS05690	COG1653	transport
A6J85_RS05700	COG2972	Histidine kinase
A6J85_RS05705	COG4753	response regulator
A6J85_RS05705	COG2207	Transcriptional regulator
A6J85_RS05710	COG2723	6-phospho-beta-galactosidase activity
A6J85_RS05715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6J85_RS05725	COG1940	carbohydrate kinase activity
A6J85_RS05730	COG0242	peptide deformylase activity
A6J85_RS05750	COG1132	(ABC) transporter
A6J85_RS05755	COG1482	cell wall glycoprotein biosynthetic process
A6J85_RS05760	COG0504	CTP synthase activity
A6J85_RS05775	COG0191	fructose-bisphosphate aldolase activity
A6J85_RS05785	COG4555	ABC transporter
A6J85_RS05825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6J85_RS05835	COG1461	Dihydroxyacetone kinase
A6J85_RS05840	COG1131	(ABC) transporter
A6J85_RS05850	COG4585	Histidine kinase
A6J85_RS05855	COG2197	response regulator
A6J85_RS05870	COG1126	abc transporter atp-binding protein
A6J85_RS05875	COG0765	amino acid transport
A6J85_RS05885	COG1968	undecaprenyl-diphosphatase activity
A6J85_RS05890	COG4862	establishment of competence for transformation
A6J85_RS05895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J85_RS05905	COG0719	Fe-S assembly protein
A6J85_RS05910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J85_RS05920	COG0719	Fe-S assembly protein
A6J85_RS05925	COG1686	Belongs to the peptidase S11 family
A6J85_RS05930	COG4166	transmembrane transport
A6J85_RS05935	COG4166	transmembrane transport
A6J85_RS05940	COG4166	transmembrane transport
A6J85_RS05945	COG4166	transmembrane transport
A6J85_RS05950	COG0601	transmembrane transport
A6J85_RS05955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J85_RS05960	COG0444	Belongs to the ABC transporter superfamily
A6J85_RS05965	COG4608	Belongs to the ABC transporter superfamily
A6J85_RS06000	COG0527	aspartate kinase activity
A6J85_RS06005	COG1024	Enoyl-CoA hydratase
A6J85_RS06015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J85_RS06025	COG2070	2-Nitropropane dioxygenase
A6J85_RS06030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J85_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
A6J85_RS06040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J85_RS06050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J85_RS06055	COG0439	Biotin carboxylase
A6J85_RS06060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J85_RS06065	COG0825	malonyl-CoA metabolic process
A6J85_RS06085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6J85_RS06090	COG1309	transcriptional regulator
A6J85_RS06115	COG3716	PTS system mannose fructose sorbose family IID component
A6J85_RS06140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J85_RS06145	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6J85_RS06160	COG4974	Belongs to the 'phage' integrase family
A6J85_RS06165	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6J85_RS06170	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6J85_RS06175	COG1187	pseudouridine synthase activity
A6J85_RS06180	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6J85_RS06190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J85_RS06195	COG0569	domain protein
A6J85_RS06205	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A6J85_RS06210	COG0671	phosphoesterase, PA-phosphatase related
A6J85_RS06220	COG1242	4 iron, 4 sulfur cluster binding
A6J85_RS06225	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6J85_RS06245	COG2226	methyltransferase
A6J85_RS06260	COG1119	ATPase activity
A6J85_RS06265	COG0628	permease
A6J85_RS06270	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6J85_RS06275	COG1253	flavin adenine dinucleotide binding
A6J85_RS06285	COG2188	Transcriptional regulator
A6J85_RS06290	COG1263	PTS System
A6J85_RS06290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J85_RS06295	COG0366	Alpha amylase catalytic
A6J85_RS06310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J85_RS06315	COG1227	inorganic diphosphatase activity
A6J85_RS06330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J85_RS06335	COG2244	polysaccharide biosynthetic process
A6J85_RS06340	COG0626	cystathionine gamma-synthase activity
A6J85_RS06345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6J85_RS06350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J85_RS06355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6J85_RS06360	COG0740	serine-type endopeptidase activity
A6J85_RS06365	COG4471	UPF0298 protein
A6J85_RS06395	COG0517	IMP dehydrogenase activity
A6J85_RS06395	COG0617	tRNA 3'-terminal CCA addition
A6J85_RS06395	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J85_RS06405	COG2348	transferase activity, transferring amino-acyl groups
A6J85_RS06415	COG1078	dGTPase activity
A6J85_RS06430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6J85_RS06450	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A6J85_RS06455	COG0372	Belongs to the citrate synthase family
A6J85_RS06460	COG0538	isocitrate dehydrogenase activity
A6J85_RS06480	COG0513	Belongs to the DEAD box helicase family
A6J85_RS06490	COG2827	Endonuclease containing a URI domain
A6J85_RS06500	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J85_RS06505	COG0204	Acyl-transferase
A6J85_RS06515	COG1555	photosystem II stabilization
A6J85_RS06515	COG1596	polysaccharide export
A6J85_RS06520	COG0658	competence protein
A6J85_RS06520	COG2333	competence protein COMEC
A6J85_RS06530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J85_RS06560	COG2235	arginine
A6J85_RS06565	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6J85_RS06570	COG0549	Belongs to the carbamate kinase family
A6J85_RS06575	COG1288	antiporter activity
A6J85_RS06580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J85_RS06585	COG1438	arginine binding
A6J85_RS06590	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6J85_RS06595	COG0363	glucosamine-6-phosphate deaminase activity
A6J85_RS06615	COG2723	6-phospho-beta-galactosidase activity
A6J85_RS06620	COG4095	Psort location CytoplasmicMembrane, score
A6J85_RS06635	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J85_RS06645	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J85_RS06660	COG4122	O-methyltransferase activity
A6J85_RS06665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J85_RS06675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J85_RS06685	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A6J85_RS06690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6J85_RS06695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6J85_RS06705	COG1476	TRANSCRIPTIONal
A6J85_RS06735	COG1597	lipid kinase activity
A6J85_RS06740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J85_RS06745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J85_RS06750	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J85_RS06765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6J85_RS06770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J85_RS06775	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J85_RS06780	COG0297	glycogen (starch) synthase activity
A6J85_RS06785	COG0058	SHG alpha-glucan phosphorylase activity
A6J85_RS06800	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J85_RS06805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6J85_RS06810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J85_RS06815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6J85_RS06820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6J85_RS06825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6J85_RS06830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6J85_RS06835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J85_RS06840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6J85_RS06845	COG0470	DNA polymerase III
A6J85_RS06850	COG4467	Involved in initiation control of chromosome replication
A6J85_RS06860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J85_RS06865	COG1393	Belongs to the ArsC family
A6J85_RS06875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J85_RS06885	COG0708	Exodeoxyribonuclease III
A6J85_RS06895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J85_RS06895	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J85_RS06905	COG1349	DNA-binding transcription factor activity
A6J85_RS06910	COG0698	ribose 5-phosphate isomerase
A6J85_RS06915	COG0698	ribose 5-phosphate isomerase
A6J85_RS06925	COG3684	Belongs to the aldolase LacD family
A6J85_RS06940	COG3775	system Galactitol-specific IIC component
A6J85_RS06945	COG0698	ribose 5-phosphate isomerase
A6J85_RS06950	COG0698	ribose 5-phosphate isomerase
A6J85_RS06955	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J85_RS06960	COG3684	Belongs to the aldolase LacD family
A6J85_RS06965	COG3711	transcriptional antiterminator
A6J85_RS06980	COG2723	6-phospho-beta-galactosidase activity
A6J85_RS07000	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A6J85_RS07015	COG0745	RESPONSE REGULATOR receiver
A6J85_RS07090	COG0577	efflux transmembrane transporter activity
A6J85_RS07105	COG3279	Response regulator of the LytR AlgR family
A6J85_RS07120	COG1309	transcriptional regulator
A6J85_RS07135	COG2226	methyltransferase
A6J85_RS07145	COG3250	beta-galactosidase activity
A6J85_RS07150	COG1136	(ABC) transporter
A6J85_RS07160	COG0531	amino acid
A6J85_RS07185	COG1028	Short-chain dehydrogenase reductase Sdr
A6J85_RS07205	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J85_RS07220	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J85_RS07225	COG0488	(ABC) transporter
A6J85_RS07250	COG1674	ftsk spoiiie
A6J85_RS07250	COG0697	spore germination
A6J85_RS07255	COG0346	lactoylglutathione lyase activity
A6J85_RS07260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J85_RS07270	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6J85_RS07275	COG0081	regulation of translation
A6J85_RS07280	COG0531	amino acid
A6J85_RS07285	COG1442	glycosyl transferase family 8
A6J85_RS07290	COG0528	UMP kinase activity
A6J85_RS07295	COG0233	cytoplasmic translational termination
A6J85_RS07300	COG2996	Protein conserved in bacteria
A6J85_RS07305	COG0768	penicillin binding
A6J85_RS07310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6J85_RS07315	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J85_RS07320	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J85_RS07325	COG1051	belongs to the nudix hydrolase family
A6J85_RS07345	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6J85_RS07350	COG2884	Cell division ATP-binding protein ftsE
A6J85_RS07355	COG2177	Part of the ABC transporter FtsEX involved in
A6J85_RS07375	COG0772	Belongs to the SEDS family
A6J85_RS07380	COG0693	protein deglycase activity
A6J85_RS07390	COG0187	DNA topoisomerase II activity
A6J85_RS07395	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A6J85_RS07405	COG0560	Phosphoserine phosphatase
A6J85_RS07425	COG0148	phosphopyruvate hydratase activity
A6J85_RS07445	COG2706	6-phosphogluconolactonase activity
A6J85_RS07460	COG1136	(ABC) transporter
A6J85_RS07465	COG0577	efflux transmembrane transporter activity
A6J85_RS07470	COG0745	RESPONSE REGULATOR receiver
A6J85_RS07475	COG3850	Histidine kinase
A6J85_RS07475	COG5002	protein histidine kinase activity
A6J85_RS07480	COG2936	dipeptidyl-peptidase activity
A6J85_RS07485	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A6J85_RS07490	COG1074	ATP-dependent DNA helicase activity
A6J85_RS07500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J85_RS07505	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A6J85_RS07510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6J85_RS07515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6J85_RS07520	COG0131	Imidazoleglycerol-phosphate dehydratase
A6J85_RS07525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6J85_RS07530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6J85_RS07535	COG0107	imidazoleglycerol-phosphate synthase activity
A6J85_RS07540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6J85_RS07545	COG0140	phosphoribosyl-ATP diphosphatase activity
A6J85_RS07555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J85_RS07560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J85_RS07565	COG4109	DRTGG domain
A6J85_RS07570	COG0024	Methionine aminopeptidase
A6J85_RS07585	COG1846	Transcriptional regulator
A6J85_RS07600	COG2246	polysaccharide biosynthetic process
A6J85_RS07610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J85_RS07615	COG1597	lipid kinase activity
A6J85_RS07620	COG1523	belongs to the glycosyl hydrolase 13 family
A6J85_RS07630	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6J85_RS07630	COG1605	Chorismate mutase
A6J85_RS07635	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6J85_RS07640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6J85_RS07645	COG0335	large ribosomal subunit rRNA binding
A6J85_RS07660	COG1368	sulfuric ester hydrolase activity
A6J85_RS07665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J85_RS07670	COG0710	3-dehydroquinate dehydratase activity
A6J85_RS07675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J85_RS07680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6J85_RS07685	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6J85_RS07690	COG0287	Prephenate dehydrogenase
A6J85_RS07695	COG3679	Belongs to the UPF0342 family
A6J85_RS07705	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6J85_RS07710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6J85_RS07715	COG0077	Prephenate dehydratase
A6J85_RS07775	COG1132	(ABC) transporter
A6J85_RS07820	COG0366	Alpha amylase catalytic
A6J85_RS07855	COG1131	(ABC) transporter
A6J85_RS07865	COG0205	6-phosphofructokinase activity
A6J85_RS07870	COG0469	pyruvate kinase activity
A6J85_RS07880	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J85_RS07890	COG1051	belongs to the nudix hydrolase family
A6J85_RS07895	COG2873	o-acetylhomoserine
A6J85_RS07915	COG2375	cellular response to nickel ion
A6J85_RS07915	COG1132	(ABC) transporter
A6J85_RS07920	COG1132	(ABC) transporter
A6J85_RS07925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J85_RS07935	COG0647	UMP catabolic process
A6J85_RS07955	COG0228	four-way junction DNA binding
A6J85_RS07970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J85_RS07975	COG0569	domain protein
A6J85_RS07990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6J85_RS07995	COG0336	Belongs to the RNA methyltransferase TrmD family
A6J85_RS08000	COG3443	Belongs to the bacterial solute-binding protein 9 family
A6J85_RS08000	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J85_RS08010	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J85_RS08025	COG1272	protein, Hemolysin III
A6J85_RS08035	COG3022	response to hydroperoxide
A6J85_RS08040	COG0431	NADPH-dependent FMN reductase
A6J85_RS08045	COG1846	Transcriptional regulator
A6J85_RS08055	COG0436	Aminotransferase
A6J85_RS08075	COG0017	Asparaginyl-tRNA synthetase
A6J85_RS08090	COG1132	(ABC) transporter
A6J85_RS08100	COG0477	Major facilitator Superfamily
A6J85_RS08115	COG0488	(ABC) transporter
A6J85_RS08120	COG0492	ferredoxin-NADP+ reductase activity
A6J85_RS08125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J85_RS08130	COG3759	membrane
A6J85_RS08155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6J85_RS08160	COG1970	mechanosensitive ion channel activity
A6J85_RS08165	COG0358	DNA primase activity
A6J85_RS08170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J85_RS08175	COG2151	metal-sulfur cluster biosynthetic enzyme
A6J85_RS08205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J85_RS08210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6J85_RS08215	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6J85_RS08220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A6J85_RS08225	COG0038	chloride channel
A6J85_RS08235	COG0813	purine-nucleoside phosphorylase activity
A6J85_RS08265	COG0543	2 iron, 2 sulfur cluster binding
A6J85_RS08270	COG0167	dihydroorotate dehydrogenase activity
A6J85_RS08275	COG0284	orotidine-5'-phosphate decarboxylase activity
A6J85_RS08280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6J85_RS08295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J85_RS08300	COG1051	belongs to the nudix hydrolase family
A6J85_RS08310	COG0737	Belongs to the 5'-nucleotidase family
A6J85_RS08315	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6J85_RS08320	COG0187	DNA topoisomerase II activity
A6J85_RS08340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J85_RS08345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J85_RS08365	COG0539	negative regulation of cytoplasmic translation
A6J85_RS08380	COG0039	L-malate dehydrogenase activity
A6J85_RS08385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J85_RS08390	COG3764	Sortase (surface protein transpeptidase)
A6J85_RS08395	COG2003	Belongs to the UPF0758 family
A6J85_RS08415	COG1104	cysteine desulfurase activity
A6J85_RS08420	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J85_RS08430	COG2357	RelA SpoT domain protein
A6J85_RS08435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6J85_RS08440	COG0564	pseudouridine synthase activity
A6J85_RS08445	COG0280	phosphate acetyltransferase
A6J85_RS08450	COG1194	a g-specific adenine glycosylase
A6J85_RS08465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J85_RS08470	COG4684	Psort location CytoplasmicMembrane, score
A6J85_RS08475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J85_RS08490	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6J85_RS08495	COG1247	-acetyltransferase
A6J85_RS08515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J85_RS08520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J85_RS08535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J85_RS08540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J85_RS08545	COG3711	transcriptional antiterminator
A6J85_RS08550	COG0110	maltose O-acetyltransferase activity
A6J85_RS08555	COG0758	DNA mediated transformation
A6J85_RS08560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J85_RS08575	COG0135	phosphoribosylanthranilate isomerase activity
A6J85_RS08580	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6J85_RS08590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6J85_RS08595	COG0222	ribosome binding
A6J85_RS08645	COG1132	(ABC) transporter
A6J85_RS08655	COG1114	Component of the transport system for branched-chain amino acids
A6J85_RS08680	COG5002	protein histidine kinase activity
A6J85_RS08685	COG0785	Cytochrome C biogenesis protein
A6J85_RS08700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J85_RS08700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J85_RS08710	COG2972	Histidine kinase
A6J85_RS08715	COG0785	Cytochrome C biogenesis protein
A6J85_RS08720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J85_RS08725	COG0431	NADPH-dependent FMN reductase
A6J85_RS08725	COG1053	succinate dehydrogenase
A6J85_RS08725	COG3976	FMN-binding domain protein
A6J85_RS08745	COG0038	chloride channel
A6J85_RS08750	COG2822	iron ion transport
A6J85_RS08755	COG2837	iron assimilation
A6J85_RS08765	COG0805	protein transport
A6J85_RS08775	COG0534	Mate efflux family protein
A6J85_RS08780	COG0516	GMP reductase activity
A6J85_RS08785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J85_RS08790	COG2233	PERMEase
A6J85_RS08795	COG1942	4-Oxalocrotonate Tautomerase
A6J85_RS08800	COG1435	thymidine kinase activity
A6J85_RS08805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J85_RS08810	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J85_RS08815	COG0009	L-threonylcarbamoyladenylate synthase
A6J85_RS08820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6J85_RS08830	COG0741	lytic transglycosylase activity
A6J85_RS08840	COG1940	carbohydrate kinase activity
A6J85_RS08845	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6J85_RS08855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6J85_RS08860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6J85_RS08865	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6J85_RS08870	COG1388	LysM domain
A6J85_RS08870	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J85_RS08880	COG2382	esterase
A6J85_RS08890	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J85_RS08895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A6J85_RS08900	COG0022	dehydrogenase e1 component
A6J85_RS08905	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6J85_RS08910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J85_RS08915	COG0095	Lipoate-protein ligase
A6J85_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
A6J85_RS08925	COG4974	Belongs to the 'phage' integrase family
A6J85_RS08990	COG0488	(ABC) transporter
A6J85_RS09005	COG0510	thiamine kinase activity
A6J85_RS09010	COG2217	Heavy metal translocating P-type atpase
A6J85_RS09015	COG0640	Transcriptional regulator
A6J85_RS09060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J85_RS09070	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A6J85_RS09075	COG2188	Transcriptional regulator
A6J85_RS09085	COG0488	(ABC) transporter
A6J85_RS09090	COG0617	tRNA 3'-terminal CCA addition
A6J85_RS09095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6J85_RS09100	COG1307	EDD domain protein, DegV family
A6J85_RS09110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J85_RS09110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J85_RS09110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J85_RS09115	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J85_RS09120	COG1349	DNA-binding transcription factor activity
A6J85_RS09130	COG0540	Belongs to the ATCase OTCase family
A6J85_RS09140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6J85_RS09150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6J85_RS09155	COG0505	Belongs to the CarA family
A6J85_RS09160	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6J85_RS09170	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J85_RS09175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J85_RS09180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6J85_RS09185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6J85_RS09200	COG0564	pseudouridine synthase activity
A6J85_RS09210	COG0583	DNA-binding transcription factor activity
A6J85_RS09225	COG1079	Belongs to the binding-protein-dependent transport system permease family
A6J85_RS09230	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6J85_RS09235	COG3845	ABC transporter
A6J85_RS09240	COG1744	ABC transporter substrate-binding protein PnrA-like
A6J85_RS09245	COG0295	cytidine deaminase activity
A6J85_RS09250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6J85_RS09285	COG5002	protein histidine kinase activity
A6J85_RS09290	COG0745	RESPONSE REGULATOR receiver
A6J85_RS09330	COG0704	Plays a role in the regulation of phosphate uptake
A6J85_RS09335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J85_RS09340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J85_RS09345	COG0581	inorganic phosphate transmembrane transporter activity
A6J85_RS09350	COG0573	inorganic phosphate transmembrane transporter activity
A6J85_RS09355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J85_RS09360	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6J85_RS09360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J85_RS09365	COG0483	inositol monophosphate 1-phosphatase activity
A6J85_RS09370	COG4476	Belongs to the UPF0223 family
A6J85_RS09375	COG1393	Belongs to the ArsC family
A6J85_RS09380	COG0196	riboflavin kinase activity
A6J85_RS09385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6J85_RS09405	COG1827	regulation of RNA biosynthetic process
A6J85_RS09435	COG0456	acetyltransferase
A6J85_RS09445	COG0556	nucleotide-excision repair
A6J85_RS09450	COG0765	amino acid transport
A6J85_RS09455	COG1126	abc transporter atp-binding protein
A6J85_RS09460	COG0346	lactoylglutathione lyase activity
A6J85_RS09465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6J85_RS09470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6J85_RS09480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6J85_RS09500	COG1368	sulfuric ester hydrolase activity
A6J85_RS09505	COG3754	Rhamnan synthesis protein F
A6J85_RS09535	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6J85_RS09540	COG0463	Glycosyl transferase, family 2
A6J85_RS09570	COG0463	Glycosyl transferase, family 2
A6J85_RS09575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J85_RS09580	COG1088	dTDP-glucose 4,6-dehydratase activity
A6J85_RS09590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6J85_RS09600	COG1051	belongs to the nudix hydrolase family
A6J85_RS09605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J85_RS09610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6J85_RS09615	COG2384	SAM-dependent methyltransferase
A6J85_RS09620	COG0625	glutathione transferase activity
A6J85_RS09630	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6J85_RS09635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J85_RS09665	COG0300	oxidoreductase activity
A6J85_RS09670	COG1234	tRNA 3'-trailer cleavage
A6J85_RS09680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J85_RS09685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6J85_RS09695	COG2814	Major facilitator Superfamily
A6J85_RS09705	COG2378	regulation of single-species biofilm formation
A6J85_RS09725	COG0765	amino acid transport
A6J85_RS09730	COG1126	abc transporter atp-binding protein
A6J85_RS09735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J85_RS09740	COG2131	deaminase
A6J85_RS09830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J85_RS09835	COG1132	(ABC) transporter
A6J85_RS09840	COG1132	(ABC) transporter
A6J85_RS09845	COG2315	Protein conserved in bacteria
A6J85_RS09850	COG3142	Participates in the control of copper homeostasis
A6J85_RS09865	COG1481	regulation of sporulation
A6J85_RS09875	COG1660	Displays ATPase and GTPase activities
A6J85_RS09880	COG0251	oxidation-reduction process
A6J85_RS09890	COG0572	uridine kinase
A6J85_RS09895	COG0673	inositol 2-dehydrogenase activity
A6J85_RS09905	COG0726	polysaccharide deacetylase
A6J85_RS09910	COG0596	Alpha beta hydrolase
A6J85_RS09915	COG1363	Peptidase, m42
A6J85_RS09935	COG3583	domain protein
A6J85_RS09935	COG3583	domain protein
A6J85_RS09945	COG3848	Pyruvate phosphate dikinase
A6J85_RS09945	COG0574	Belongs to the PEP-utilizing enzyme family
A6J85_RS09955	COG0688	phosphatidylethanolamine metabolic process
A6J85_RS09960	COG1183	phosphatidylcholine synthase activity
A6J85_RS09975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J85_RS09985	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J85_RS09990	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6J85_RS09995	COG1609	Transcriptional regulator
A6J85_RS10000	COG1230	cation diffusion facilitator family transporter
A6J85_RS10015	COG3201	nicotinamide mononucleotide transporter
A6J85_RS10035	COG1122	ATPase activity
A6J85_RS10040	COG1122	ATPase activity
A6J85_RS10045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A6J85_RS10060	COG1125	glycine betaine transport
A6J85_RS10060	COG0517	IMP dehydrogenase activity
A6J85_RS10070	COG1846	Transcriptional regulator
A6J85_RS10080	COG0066	3-isopropylmalate dehydratase activity
A6J85_RS10085	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6J85_RS10125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J85_RS10130	COG1956	GAF domain-containing protein
A6J85_RS10135	COG0596	Alpha beta hydrolase
A6J85_RS10145	COG3620	sequence-specific DNA binding
A6J85_RS10155	COG2813	Specifically methylates the guanine in position
A6J85_RS10170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6J85_RS10180	COG4932	domain protein
A6J85_RS10185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J85_RS10195	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A6J85_RS10200	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J85_RS10205	COG3442	glutamine amidotransferase
A6J85_RS10230	COG0488	(ABC) transporter
A6J85_RS10240	COG1136	(ABC) transporter
A6J85_RS10245	COG0577	efflux transmembrane transporter activity
A6J85_RS10275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J85_RS10275	COG0072	phenylalanine-tRNA ligase activity
A6J85_RS10290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J85_RS10305	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A6J85_RS10315	COG3527	Alpha-acetolactate decarboxylase
A6J85_RS10325	COG0628	permease
A6J85_RS10330	COG0716	FMN binding
A6J85_RS10335	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J85_RS10340	COG0254	rRNA binding
A6J85_RS10370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J85_RS10375	COG0604	alcohol dehydrogenase
A6J85_RS10375	COG3321	synthase
A6J85_RS10395	COG1573	uracil-dna glycosylase
A6J85_RS10445	COG1304	FMN binding
A6J85_RS10555	COG0322	excinuclease ABC activity
A6J85_RS10560	COG1011	Hydrolase
A6J85_RS10580	COG0481	GTPase activity
A6J85_RS10585	COG0561	phosphatase activity
A6J85_RS10595	COG0425	Belongs to the sulfur carrier protein TusA family
A6J85_RS10595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J85_RS10600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6J85_RS10610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6J85_RS10620	COG0301	tRNA thio-modification
A6J85_RS10625	COG1104	cysteine desulfurase activity
A6J85_RS10630	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A6J85_RS10635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6J85_RS10640	COG0517	IMP dehydrogenase activity
A6J85_RS10645	COG0574	Belongs to the PEP-utilizing enzyme family
A6J85_RS10645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J85_RS10660	COG1177	transmembrane transport
A6J85_RS10665	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J85_RS10670	COG3842	ATPase activity
A6J85_RS10675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6J85_RS10685	COG0083	homoserine kinase activity
A6J85_RS10705	COG1131	(ABC) transporter
A6J85_RS10710	COG4187	Peptidase family M20/M25/M40
A6J85_RS10730	COG3091	SprT-like family
A6J85_RS10735	COG2183	response to ionizing radiation
A6J85_RS10740	COG0701	Predicted permease
A6J85_RS10745	COG3689	TIGRFAM TIGR03943 family protein
A6J85_RS10760	COG0561	phosphatase activity
A6J85_RS10765	COG0561	phosphatase activity
A6J85_RS10770	COG1196	nuclear chromosome segregation
A6J85_RS10775	COG0571	ribonuclease III activity
A6J85_RS10780	COG2832	Protein of unknown function (DUF454)
A6J85_RS10785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6J85_RS10795	COG0745	RESPONSE REGULATOR receiver
A6J85_RS10800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6J85_RS10815	COG0438	transferase activity, transferring glycosyl groups
A6J85_RS10825	COG1609	Transcriptional regulator
A6J85_RS10830	COG0006	proline dipeptidase activity
A6J85_RS10835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J85_RS10845	COG2819	hydrolase of the alpha beta superfamily
A6J85_RS10860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J85_RS10870	COG0149	triose-phosphate isomerase activity
A6J85_RS10875	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J85_RS10880	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6J85_RS10885	COG0772	Belongs to the SEDS family
A6J85_RS10890	COG0386	Belongs to the glutathione peroxidase family
A6J85_RS10905	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6J85_RS10910	COG0588	phosphoglycerate mutase activity
A6J85_RS10915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6J85_RS10920	COG0577	efflux transmembrane transporter activity
A6J85_RS10925	COG1136	(ABC) transporter