locus-tag	class	description
CO687_RS00020	COG0519	Catalyzes the synthesis of GMP from XMP
CO687_RS00045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CO687_RS00050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CO687_RS00055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO687_RS00060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO687_RS00070	COG2137	regulation of response to DNA damage stimulus
CO687_RS00075	COG3557	Belongs to the UPF0374 family
CO687_RS00180	COG4585	Histidine kinase
CO687_RS00190	COG2815	serine threonine protein kinase
CO687_RS00190	COG0515	serine threonine protein kinase
CO687_RS00195	COG0631	protein serine/threonine phosphatase activity
CO687_RS00200	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO687_RS00200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO687_RS00205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO687_RS00210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CO687_RS00215	COG1758	RNA polymerase activity
CO687_RS00220	COG0194	GDP metabolic process
CO687_RS00225	COG1418	mRNA catabolic process
CO687_RS00230	COG1854	S-ribosylhomocysteine lyase activity
CO687_RS00240	COG0116	Belongs to the methyltransferase superfamily
CO687_RS00250	COG3599	regulation of cell shape
CO687_RS00255	COG4474	Belongs to the UPF0398 family
CO687_RS00260	COG3331	DNA recombination
CO687_RS00265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO687_RS00270	COG3579	cysteine-type endopeptidase activity
CO687_RS00275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO687_RS00280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CO687_RS00285	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO687_RS00290	COG0492	ferredoxin-NADP+ reductase activity
CO687_RS00300	COG1126	abc transporter atp-binding protein
CO687_RS00310	COG0513	Belongs to the DEAD box helicase family
CO687_RS00315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO687_RS00320	COG0768	penicillin binding
CO687_RS00330	COG0275	rRNA processing
CO687_RS00350	COG4224	UPF0291 protein
CO687_RS00355	COG0751	glycine-tRNA ligase activity
CO687_RS00360	COG0752	glycyl-tRNA synthetase alpha subunit
CO687_RS00370	COG1064	alcohol dehydrogenase
CO687_RS00395	COG0656	L-ascorbic acid biosynthetic process
CO687_RS00410	COG1283	sodium-dependent phosphate transmembrane transporter activity
CO687_RS00415	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CO687_RS00420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CO687_RS00430	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CO687_RS00435	COG0195	Participates in both transcription termination and antitermination
CO687_RS00440	COG0779	Required for maturation of 30S ribosomal subunits
CO687_RS00445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO687_RS00460	COG1131	(ABC) transporter
CO687_RS00465	COG0537	adenosine 5'-monophosphoramidase activity
CO687_RS00475	COG1316	TRANSCRIPTIONal
CO687_RS00485	COG0802	atpase or kinase
CO687_RS00490	COG2252	PERMEase
CO687_RS00500	COG0561	phosphatase activity
CO687_RS00505	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CO687_RS00510	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CO687_RS00515	COG0440	acetolactate synthase activity
CO687_RS00520	COG0028	Belongs to the TPP enzyme family
CO687_RS00535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO687_RS00540	COG1254	Belongs to the acylphosphatase family
CO687_RS00555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO687_RS00560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CO687_RS00570	COG0456	acetyltransferase
CO687_RS00575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CO687_RS00585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CO687_RS00590	COG1160	GTP binding
CO687_RS00600	COG1484	DNA-dependent DNA replication
CO687_RS00610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CO687_RS00625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO687_RS00625	COG1263	PTS System
CO687_RS00625	COG2190	(PTS) system
CO687_RS00630	COG0745	RESPONSE REGULATOR receiver
CO687_RS00635	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CO687_RS00640	COG2268	Band 7 protein
CO687_RS00650	COG1396	sequence-specific DNA binding
CO687_RS00660	COG5263	repeat protein
CO687_RS00660	COG0366	Alpha amylase catalytic
CO687_RS00660	COG0366	Alpha amylase catalytic
CO687_RS00660	COG5263	repeat protein
CO687_RS00665	COG1396	sequence-specific DNA binding
CO687_RS00670	COG0501	Belongs to the peptidase M48B family
CO687_RS00675	COG1704	LemA family
CO687_RS00680	COG1309	transcriptional regulator
CO687_RS00690	COG0357	Ribosomal RNA small subunit methyltransferase G
CO687_RS00705	COG1122	ATPase activity
CO687_RS00715	COG2357	RelA SpoT domain protein
CO687_RS00720	COG0745	RESPONSE REGULATOR receiver
CO687_RS00755	COG1054	Belongs to the UPF0176 family
CO687_RS00790	COG4720	Psort location CytoplasmicMembrane, score
CO687_RS00800	COG1129	ABC transporter
CO687_RS00815	COG1132	(ABC) transporter
CO687_RS00820	COG4988	ABC transporter
CO687_RS00830	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO687_RS00835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO687_RS00840	COG1464	Belongs to the NlpA lipoprotein family
CO687_RS00845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO687_RS00850	COG1473	amidohydrolase
CO687_RS00860	COG0217	transcriptional regulatory protein
CO687_RS00870	COG1323	Belongs to the UPF0348 family
CO687_RS00875	COG2226	methyltransferase
CO687_RS00880	COG0799	negative regulation of ribosome biogenesis
CO687_RS00885	COG1335	isochorismatase
CO687_RS00890	COG1713	HD superfamily hydrolase involved in NAD metabolism
CO687_RS00895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CO687_RS00900	COG1534	Rna-binding protein
CO687_RS00905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO687_RS00910	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CO687_RS00925	COG0697	spore germination
CO687_RS00930	COG1063	alcohol dehydrogenase
CO687_RS00940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO687_RS00945	COG0154	amidase activity
CO687_RS00950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO687_RS00955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO687_RS00960	COG1335	isochorismatase
CO687_RS00965	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CO687_RS00975	COG0436	Aminotransferase
CO687_RS00980	COG0589	response to stress
CO687_RS00985	COG0561	phosphatase activity
CO687_RS00990	COG0252	asparaginase activity
CO687_RS01010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO687_RS01015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CO687_RS01020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CO687_RS01025	COG0736	holo-[acyl-carrier-protein] synthase activity
CO687_RS01030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CO687_RS01045	COG3343	RNA polymerase activity
CO687_RS01050	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO687_RS01055	COG4475	Protein of unknown function (DUF436)
CO687_RS01060	COG4720	Psort location CytoplasmicMembrane, score
CO687_RS01065	COG0351	phosphomethylpyrimidine kinase
CO687_RS01070	COG3064	Membrane
CO687_RS01075	COG0101	tRNA pseudouridine synthase activity
CO687_RS01085	COG3583	domain protein
CO687_RS01085	COG3064	Membrane
CO687_RS01085	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CO687_RS01090	COG0484	heat shock protein binding
CO687_RS01105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO687_RS01110	COG1420	regulation of RNA biosynthetic process
CO687_RS01145	COG1876	peptidase activity
CO687_RS01150	COG0588	phosphoglycerate mutase activity
CO687_RS01160	COG2848	UPF0210 protein
CO687_RS01165	COG3830	Belongs to the UPF0237 family
CO687_RS01175	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CO687_RS01180	COG4978	Transcriptional regulator
CO687_RS01180	COG0789	Transcriptional regulator
CO687_RS01185	COG1621	beta-fructofuranosidase activity
CO687_RS01185	COG5492	domain, Protein
CO687_RS01185	COG3583	domain protein
CO687_RS01195	COG1301	dicarboxylic acid transport
CO687_RS01205	COG2323	membrane
CO687_RS01210	COG3237	CsbD-like
CO687_RS01225	COG3290	protein histidine kinase activity
CO687_RS01285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CO687_RS01290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO687_RS01305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO687_RS01315	COG0531	amino acid
CO687_RS01320	COG3842	ATPase activity
CO687_RS01330	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CO687_RS01335	COG0215	cysteine-tRNA ligase activity
CO687_RS01355	COG1045	serine acetyltransferase
CO687_RS01360	COG1185	polyribonucleotide nucleotidyltransferase activity
CO687_RS01370	COG2814	Major facilitator Superfamily
CO687_RS01375	COG1164	Oligoendopeptidase f
CO687_RS01390	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO687_RS01395	COG3118	belongs to the thioredoxin family
CO687_RS01410	COG2267	carboxylic ester hydrolase activity
CO687_RS01465	COG1187	pseudouridine synthase activity
CO687_RS01475	COG0242	peptide deformylase activity
CO687_RS01495	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CO687_RS01495	COG1404	Belongs to the peptidase S8 family
CO687_RS01505	COG0588	phosphoglycerate mutase activity
CO687_RS01510	COG0588	phosphoglycerate mutase activity
CO687_RS01515	COG0561	phosphatase activity
CO687_RS01520	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CO687_RS01530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO687_RS01540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CO687_RS01545	COG1131	(ABC) transporter
CO687_RS01570	COG1131	(ABC) transporter
CO687_RS01590	COG5002	protein histidine kinase activity
CO687_RS01595	COG0745	RESPONSE REGULATOR receiver
CO687_RS01600	COG2723	6-phospho-beta-galactosidase activity
CO687_RS01610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CO687_RS01625	COG0028	Belongs to the TPP enzyme family
CO687_RS01640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO687_RS01650	COG2207	Transcriptional regulator
CO687_RS01670	COG1263	PTS System
CO687_RS01670	COG2190	(PTS) system
CO687_RS01670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO687_RS01685	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO687_RS01685	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO687_RS01690	COG0167	dihydroorotate dehydrogenase activity
CO687_RS01695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CO687_RS01710	COG5504	Zn-dependent protease
CO687_RS01715	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CO687_RS01725	COG0668	transmembrane transport
CO687_RS01730	COG0531	amino acid
CO687_RS01740	COG0583	DNA-binding transcription factor activity
CO687_RS01750	COG3118	belongs to the thioredoxin family
CO687_RS01765	COG1193	negative regulation of DNA recombination
CO687_RS01780	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO687_RS01785	COG0681	Belongs to the peptidase S26 family
CO687_RS01790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO687_RS01795	COG1309	transcriptional regulator
CO687_RS01825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO687_RS01830	COG1882	Formate acetyltransferase
CO687_RS01845	COG3425	synthase
CO687_RS01855	COG1304	FMN binding
CO687_RS01875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO687_RS01890	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO687_RS01910	COG0584	glycerophosphoryl diester phosphodiesterase
CO687_RS01920	COG2081	HI0933 family
CO687_RS01925	COG0789	Transcriptional regulator
CO687_RS01935	COG2226	methyltransferase
CO687_RS01950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CO687_RS01960	COG1214	PFAM Peptidase M22, glycoprotease
CO687_RS01965	COG5503	Protein of unknown function (DUF1447)
CO687_RS01980	COG1914	H( )-stimulated, divalent metal cation uptake system
CO687_RS01990	COG0174	glutamine synthetase
CO687_RS01995	COG0789	Transcriptional regulator
CO687_RS02005	COG3942	CHAP domain
CO687_RS02015	COG0126	phosphoglycerate kinase activity
CO687_RS02030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO687_RS02035	COG0049	tRNA binding
CO687_RS02040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CO687_RS02055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO687_RS02060	COG3481	metal-dependent phosphohydrolase, HD sub domain
CO687_RS02070	COG1564	THIamine pyrophosphokinase
CO687_RS02080	COG1162	GTPase activity
CO687_RS02100	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO687_RS02125	COG0084	hydrolase, TatD family'
CO687_RS02140	COG3655	Transcriptional regulator
CO687_RS02150	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CO687_RS02165	COG1847	R3H domain protein
CO687_RS02175	COG0594	ribonuclease P activity
CO687_RS02180	COG0165	Argininosuccinate lyase
CO687_RS02185	COG0137	argininosuccinate synthase activity
CO687_RS02190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO687_RS02220	COG0756	dUTP diphosphatase activity
CO687_RS02235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CO687_RS02240	COG1132	(ABC) transporter
CO687_RS02245	COG1132	(ABC) transporter
CO687_RS02250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO687_RS02255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO687_RS02270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CO687_RS02275	COG1473	amidohydrolase
CO687_RS02280	COG2171	N-acyltransferase activity
CO687_RS02300	COG0166	Belongs to the GPI family
CO687_RS02320	COG0343	queuine tRNA-ribosyltransferase activity
CO687_RS02355	COG1832	CoA-binding protein
CO687_RS02360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO687_RS02360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO687_RS02370	COG0546	phosphoglycolate phosphatase activity
CO687_RS02390	COG1394	ATPase activity, coupled to movement of substances
CO687_RS02395	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CO687_RS02400	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CO687_RS02410	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CO687_RS02415	COG1527	subunit (C
CO687_RS02425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO687_RS02430	COG1269	ATP hydrolysis coupled proton transport
CO687_RS02445	COG1737	Transcriptional regulator
CO687_RS02455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CO687_RS02465	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CO687_RS02490	COG1454	alcohol dehydrogenase
CO687_RS02490	COG1012	belongs to the aldehyde dehydrogenase family
CO687_RS02495	COG2755	lipolytic protein G-D-S-L family
CO687_RS02495	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CO687_RS02505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CO687_RS02515	COG2255	four-way junction helicase activity
CO687_RS02525	COG0058	SHG alpha-glucan phosphorylase activity
CO687_RS02530	COG1640	4-alpha-glucanotransferase
CO687_RS02535	COG2182	Extracellular solute-binding protein
CO687_RS02540	COG1175	transmembrane transport
CO687_RS02545	COG3833	ABC-type maltose transport systems, permease component
CO687_RS02550	COG5521	maltodextrose utilization protein MalA
CO687_RS02555	COG1609	Transcriptional regulator
CO687_RS02560	COG1523	belongs to the glycosyl hydrolase 13 family
CO687_RS02565	COG1780	Probably involved in ribonucleotide reductase function
CO687_RS02580	COG1619	proteins homologs of microcin C7 resistance protein MccF
CO687_RS02600	COG1511	domain protein
CO687_RS02610	COG1230	cation diffusion facilitator family transporter
CO687_RS02620	COG2807	transmembrane transport
CO687_RS02630	COG1349	DNA-binding transcription factor activity
CO687_RS02635	COG0561	phosphatase activity
CO687_RS02750	COG4499	WXG100 protein secretion system (Wss), protein YukC
CO687_RS02780	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CO687_RS02785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO687_RS02790	COG1696	Membrane protein involved in D-alanine export
CO687_RS02825	COG2222	sugar isomerase
CO687_RS02835	COG3716	PTS system mannose fructose sorbose family IID component
CO687_RS02845	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO687_RS02860	COG0138	bifunctional purine biosynthesis protein purh
CO687_RS02870	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CO687_RS02875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO687_RS02885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO687_RS02890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CO687_RS02895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO687_RS02900	COG0416	fatty acid biosynthetic process
CO687_RS02905	COG1381	Involved in DNA repair and RecF pathway recombination
CO687_RS02910	COG0436	Aminotransferase
CO687_RS02920	COG0305	Participates in initiation and elongation during chromosome replication
CO687_RS02925	COG0359	binds to the 23S rRNA
CO687_RS02935	COG0445	tRNA wobble uridine modification
CO687_RS02940	COG0482	sulfurtransferase activity
CO687_RS02950	COG1760	l-serine dehydratase
CO687_RS02955	COG1760	l-serine dehydratase
CO687_RS02960	COG0741	lytic transglycosylase activity
CO687_RS02965	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CO687_RS02970	COG1122	ATPase activity
CO687_RS02975	COG1122	ATPase activity
CO687_RS02980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CO687_RS02990	COG0612	Peptidase, M16
CO687_RS02995	COG0612	Peptidase, M16
CO687_RS03005	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO687_RS03010	COG0517	IMP dehydrogenase activity
CO687_RS03010	COG0516	GMP reductase activity
CO687_RS03015	COG0180	Tryptophanyl-tRNA synthetase
CO687_RS03020	COG0488	(ABC) transporter
CO687_RS03040	COG0592	DNA-directed DNA polymerase activity
CO687_RS03050	COG1475	DNA binding
CO687_RS03055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO687_RS03060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CO687_RS03095	COG0012	GTP binding
CO687_RS03100	COG0193	aminoacyl-tRNA hydrolase activity
CO687_RS03105	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CO687_RS03110	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CO687_RS03130	COG0037	tRNA processing
CO687_RS03135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CO687_RS03140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO687_RS03265	COG1792	Involved in formation and maintenance of cell shape
CO687_RS03275	COG3942	CHAP domain
CO687_RS03280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO687_RS03290	COG4509	Sortase family
CO687_RS03305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CO687_RS03310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CO687_RS03315	COG1116	anion transmembrane transporter activity
CO687_RS03320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CO687_RS03325	COG2274	protein secretion by the type I secretion system
CO687_RS03330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CO687_RS03335	COG3942	CHAP domain
CO687_RS03340	COG0151	Belongs to the GarS family
CO687_RS03350	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CO687_RS03375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO687_RS03380	COG2249	NAD(P)H dehydrogenase (quinone) activity
CO687_RS03410	COG0582	viral genome integration into host DNA
CO687_RS03430	COG1674	ftsk spoiiie
CO687_RS03465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO687_RS03470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CO687_RS03475	COG0129	dihydroxy-acid dehydratase activity
CO687_RS03480	COG2151	metal-sulfur cluster biosynthetic enzyme
CO687_RS03485	COG0124	histidyl-tRNA synthetase
CO687_RS03500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO687_RS03505	COG0018	arginyl-trna synthetase
CO687_RS03510	COG1438	arginine binding
CO687_RS03515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO687_RS03530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CO687_RS03540	COG1395	domain, Protein
CO687_RS03545	COG0632	four-way junction helicase activity
CO687_RS03550	COG2818	Glycosylase
CO687_RS03565	COG1058	Belongs to the CinA family
CO687_RS03565	COG1546	Belongs to the CinA family
CO687_RS03570	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CO687_RS03575	COG1393	Belongs to the ArsC family
CO687_RS03585	COG4472	Bacterial protein of unknown function (DUF965)
CO687_RS03590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CO687_RS03595	COG3906	Belongs to the UPF0473 family
CO687_RS03600	COG0285	dihydrofolate synthase activity
CO687_RS03610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO687_RS03620	COG1328	CTP reductase activity
CO687_RS03645	COG0602	queuosine metabolic process
CO687_RS03655	COG4464	protein tyrosine phosphatase activity
CO687_RS03660	COG3944	biosynthesis protein
CO687_RS03665	COG0489	protein tyrosine kinase activity
CO687_RS03680	COG0297	glycogen (starch) synthase activity
CO687_RS03690	COG1442	glycosyl transferase family 8
CO687_RS03690	COG1216	Glycosyl transferase, family 2
CO687_RS03705	COG0562	UDP-galactopyranose mutase
CO687_RS03710	COG0438	transferase activity, transferring glycosyl groups
CO687_RS03725	COG0564	pseudouridine synthase activity
CO687_RS03730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO687_RS03735	COG2321	neutral zinc metallopeptidase
CO687_RS03740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO687_RS03755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO687_RS03775	COG0052	Belongs to the universal ribosomal protein uS2 family
CO687_RS03780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CO687_RS03790	COG4463	regulation of RNA biosynthetic process
CO687_RS03805	COG3201	nicotinamide mononucleotide transporter
CO687_RS03820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO687_RS03825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CO687_RS03830	COG2918	glutathione biosynthetic process
CO687_RS03830	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO687_RS03835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CO687_RS03845	COG0051	transcription antitermination factor activity, RNA binding
CO687_RS03850	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CO687_RS03855	COG0088	Forms part of the polypeptide exit tunnel
CO687_RS03860	COG0089	rRNA binding
CO687_RS03865	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO687_RS03870	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CO687_RS03875	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CO687_RS03880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CO687_RS03885	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CO687_RS03890	COG0255	Belongs to the universal ribosomal protein uL29 family
CO687_RS03895	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CO687_RS03900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CO687_RS03905	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CO687_RS03910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO687_RS03915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO687_RS03920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CO687_RS03925	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CO687_RS03930	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CO687_RS03935	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO687_RS03940	COG1841	ribosomal large subunit assembly
CO687_RS03945	COG0200	Binds to the 23S rRNA
CO687_RS03950	COG0201	protein transport
CO687_RS03955	COG0563	adenylate kinase activity
CO687_RS03960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CO687_RS03965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CO687_RS03970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO687_RS03975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO687_RS03980	COG0202	RNA polymerase activity
CO687_RS03985	COG0203	ribosomal protein L17
CO687_RS04075	COG1846	Transcriptional regulator
CO687_RS04080	COG1121	(ABC) transporter
CO687_RS04085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO687_RS04090	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO687_RS04090	COG3443	Belongs to the bacterial solute-binding protein 9 family
CO687_RS04100	COG2217	Heavy metal translocating P-type atpase
CO687_RS04120	COG0500	methyltransferase
CO687_RS04125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CO687_RS04140	COG0085	RNA polymerase activity
CO687_RS04145	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CO687_RS04155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CO687_RS04160	COG1459	type II secretion system
CO687_RS04165	COG4537	Required for transformation and DNA binding
CO687_RS04195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CO687_RS04205	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CO687_RS04210	COG0285	dihydrofolate synthase activity
CO687_RS04215	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CO687_RS04215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CO687_RS04220	COG1131	(ABC) transporter
CO687_RS04260	COG4868	Belongs to the UPF0371 family
CO687_RS04270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO687_RS04275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO687_RS04285	COG1363	Peptidase, m42
CO687_RS04295	COG4585	Histidine kinase
CO687_RS04300	COG2197	response regulator
CO687_RS04320	COG3715	PTS system
CO687_RS04325	COG3716	PTS system mannose fructose sorbose family IID component
CO687_RS04335	COG4120	Belongs to the binding-protein-dependent transport system permease family
CO687_RS04365	COG0302	gtp cyclohydrolase
CO687_RS04370	COG0360	Binds together with S18 to 16S ribosomal RNA
CO687_RS04375	COG0629	single-stranded DNA binding
CO687_RS04380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CO687_RS04425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO687_RS04430	COG0006	proline dipeptidase activity
CO687_RS04445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CO687_RS04455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO687_RS04460	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
CO687_RS04465	COG1609	Transcriptional regulator
CO687_RS04470	COG1621	beta-fructofuranosidase activity
CO687_RS04480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO687_RS04480	COG2190	(PTS) system
CO687_RS04480	COG1263	PTS System
CO687_RS04495	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CO687_RS04500	COG4589	Belongs to the CDS family
CO687_RS04505	COG0750	zinc metalloprotease
CO687_RS04510	COG0442	prolyl-tRNA aminoacylation
CO687_RS04530	COG2176	DNA-directed DNA polymerase activity
CO687_RS04535	COG0464	growth
CO687_RS04540	COG2309	aminopeptidase activity
CO687_RS04550	COG2261	transglycosylase associated protein
CO687_RS04575	COG3237	CsbD-like
CO687_RS04595	COG2261	transglycosylase associated protein
CO687_RS04600	COG3711	transcriptional antiterminator
CO687_RS04625	COG0628	permease
CO687_RS04645	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO687_RS04660	COG1051	belongs to the nudix hydrolase family
CO687_RS04675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CO687_RS04685	COG1490	D-aminoacyl-tRNA deacylase activity
CO687_RS04700	COG1673	EVE domain
CO687_RS04705	COG1846	Transcriptional regulator
CO687_RS04725	COG0010	Belongs to the arginase family
CO687_RS04735	COG2986	histidine ammonia-lyase
CO687_RS04740	COG0531	amino acid
CO687_RS04750	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO687_RS04755	COG3404	Formiminotransferase-cyclodeaminase
CO687_RS04765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CO687_RS04770	COG1228	amidohydrolase
CO687_RS04795	COG3590	peptidase
CO687_RS04815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO687_RS04825	COG0495	leucyl-tRNA aminoacylation
CO687_RS04875	COG1063	alcohol dehydrogenase
CO687_RS04895	COG3537	Alpha-1,2-mannosidase
CO687_RS04905	COG0383	alpha-mannosidase activity
CO687_RS04920	COG4209	transmembrane transport
CO687_RS04925	COG0395	ABC-type sugar transport system, permease component
CO687_RS04930	COG1653	transport
CO687_RS04940	COG2972	Histidine kinase
CO687_RS04945	COG4753	response regulator
CO687_RS04945	COG2207	Transcriptional regulator
CO687_RS04950	COG2723	6-phospho-beta-galactosidase activity
CO687_RS04955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO687_RS04965	COG1940	carbohydrate kinase activity
CO687_RS04970	COG0242	peptide deformylase activity
CO687_RS04990	COG1132	(ABC) transporter
CO687_RS04995	COG1482	cell wall glycoprotein biosynthetic process
CO687_RS05000	COG0504	CTP synthase activity
CO687_RS05015	COG0191	fructose-bisphosphate aldolase activity
CO687_RS05020	COG4555	ABC transporter
CO687_RS05055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO687_RS05065	COG1461	Dihydroxyacetone kinase
CO687_RS05070	COG1131	(ABC) transporter
CO687_RS05080	COG4585	Histidine kinase
CO687_RS05085	COG2197	response regulator
CO687_RS05100	COG1126	abc transporter atp-binding protein
CO687_RS05105	COG0765	amino acid transport
CO687_RS05115	COG1968	undecaprenyl-diphosphatase activity
CO687_RS05120	COG4862	establishment of competence for transformation
CO687_RS05125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO687_RS05135	COG0719	Fe-S assembly protein
CO687_RS05140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CO687_RS05150	COG0719	Fe-S assembly protein
CO687_RS05155	COG1686	Belongs to the peptidase S11 family
CO687_RS05160	COG4166	transmembrane transport
CO687_RS05165	COG4166	transmembrane transport
CO687_RS05170	COG4166	transmembrane transport
CO687_RS05175	COG4166	transmembrane transport
CO687_RS05180	COG0601	transmembrane transport
CO687_RS05185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO687_RS05190	COG0444	Belongs to the ABC transporter superfamily
CO687_RS05195	COG4608	Belongs to the ABC transporter superfamily
CO687_RS05230	COG0527	aspartate kinase activity
CO687_RS05235	COG1024	Enoyl-CoA hydratase
CO687_RS05245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO687_RS05255	COG2070	2-Nitropropane dioxygenase
CO687_RS05260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CO687_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
CO687_RS05270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO687_RS05280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO687_RS05285	COG0439	Biotin carboxylase
CO687_RS05290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CO687_RS05295	COG0825	malonyl-CoA metabolic process
CO687_RS05320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO687_RS05325	COG1309	transcriptional regulator
CO687_RS05350	COG3716	PTS system mannose fructose sorbose family IID component
CO687_RS05375	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CO687_RS05380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CO687_RS05395	COG4974	Belongs to the 'phage' integrase family
CO687_RS05400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CO687_RS05405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CO687_RS05410	COG1187	pseudouridine synthase activity
CO687_RS05415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CO687_RS05430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO687_RS05435	COG0569	domain protein
CO687_RS05445	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CO687_RS05450	COG0671	phosphoesterase, PA-phosphatase related
CO687_RS05460	COG1242	4 iron, 4 sulfur cluster binding
CO687_RS05465	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CO687_RS05470	COG1309	transcriptional regulator
CO687_RS05485	COG2226	methyltransferase
CO687_RS05500	COG1119	ATPase activity
CO687_RS05505	COG0628	permease
CO687_RS05510	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CO687_RS05515	COG1253	flavin adenine dinucleotide binding
CO687_RS05525	COG2188	Transcriptional regulator
CO687_RS05530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO687_RS05530	COG1263	PTS System
CO687_RS05535	COG0366	Alpha amylase catalytic
CO687_RS05550	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CO687_RS05555	COG1227	inorganic diphosphatase activity
CO687_RS05570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CO687_RS05575	COG2244	polysaccharide biosynthetic process
CO687_RS05580	COG0626	cystathionine gamma-synthase activity
CO687_RS05585	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CO687_RS05590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO687_RS05595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CO687_RS05600	COG0740	serine-type endopeptidase activity
CO687_RS05605	COG4471	UPF0298 protein
CO687_RS05635	COG0517	IMP dehydrogenase activity
CO687_RS05645	COG2348	transferase activity, transferring amino-acyl groups
CO687_RS05655	COG1078	dGTPase activity
CO687_RS05670	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CO687_RS05690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CO687_RS05695	COG0372	Belongs to the citrate synthase family
CO687_RS05700	COG0538	isocitrate dehydrogenase activity
CO687_RS05720	COG0513	Belongs to the DEAD box helicase family
CO687_RS05730	COG2827	Endonuclease containing a URI domain
CO687_RS05735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CO687_RS05740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO687_RS05745	COG0204	Acyl-transferase
CO687_RS05755	COG1555	photosystem II stabilization
CO687_RS05755	COG1596	polysaccharide export
CO687_RS05760	COG2333	competence protein COMEC
CO687_RS05760	COG0658	competence protein
CO687_RS05770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CO687_RS05780	COG4377	Putative membrane peptidase family (DUF2324)
CO687_RS05785	COG0640	Transcriptional regulator
CO687_RS05800	COG2235	arginine
CO687_RS05805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CO687_RS05810	COG0549	Belongs to the carbamate kinase family
CO687_RS05815	COG1288	antiporter activity
CO687_RS05820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO687_RS05825	COG1438	arginine binding
CO687_RS05830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CO687_RS05835	COG0363	glucosamine-6-phosphate deaminase activity
CO687_RS05860	COG4122	O-methyltransferase activity
CO687_RS05865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO687_RS05875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO687_RS05880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CO687_RS05885	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CO687_RS05890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CO687_RS05895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CO687_RS05905	COG1476	TRANSCRIPTIONal
CO687_RS05930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO687_RS05935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO687_RS05940	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CO687_RS05955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CO687_RS05960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CO687_RS05965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CO687_RS05970	COG0297	glycogen (starch) synthase activity
CO687_RS05975	COG0058	SHG alpha-glucan phosphorylase activity
CO687_RS05990	COG0356	it plays a direct role in the translocation of protons across the membrane
CO687_RS05995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO687_RS06000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO687_RS06005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CO687_RS06010	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CO687_RS06015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CO687_RS06020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CO687_RS06025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO687_RS06030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CO687_RS06035	COG0470	DNA polymerase III
CO687_RS06040	COG4467	Involved in initiation control of chromosome replication
CO687_RS06050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO687_RS06055	COG1393	Belongs to the ArsC family
CO687_RS06065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CO687_RS06075	COG0708	Exodeoxyribonuclease III
CO687_RS06085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO687_RS06085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO687_RS06100	COG1349	DNA-binding transcription factor activity
CO687_RS06105	COG0698	ribose 5-phosphate isomerase
CO687_RS06110	COG0698	ribose 5-phosphate isomerase
CO687_RS06120	COG3684	Belongs to the aldolase LacD family
CO687_RS06135	COG3775	system Galactitol-specific IIC component
CO687_RS06140	COG0698	ribose 5-phosphate isomerase
CO687_RS06145	COG0698	ribose 5-phosphate isomerase
CO687_RS06150	COG1105	Belongs to the carbohydrate kinase PfkB family
CO687_RS06155	COG3684	Belongs to the aldolase LacD family
CO687_RS06160	COG3711	transcriptional antiterminator
CO687_RS06175	COG2723	6-phospho-beta-galactosidase activity
CO687_RS06195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CO687_RS06210	COG0745	RESPONSE REGULATOR receiver
CO687_RS06235	COG1136	(ABC) transporter
CO687_RS06240	COG0577	efflux transmembrane transporter activity
CO687_RS06255	COG3279	Response regulator of the LytR AlgR family
CO687_RS06270	COG1309	transcriptional regulator
CO687_RS06285	COG2226	methyltransferase
CO687_RS06295	COG3250	beta-galactosidase activity
CO687_RS06300	COG1136	(ABC) transporter
CO687_RS06305	COG0577	efflux transmembrane transporter activity
CO687_RS06310	COG0531	amino acid
CO687_RS06315	COG0456	acetyltransferase
CO687_RS06335	COG1028	Short-chain dehydrogenase reductase Sdr
CO687_RS06355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO687_RS06375	COG0488	(ABC) transporter
CO687_RS06390	COG0494	nUDIX hydrolase
CO687_RS06400	COG1674	ftsk spoiiie
CO687_RS06400	COG0697	spore germination
CO687_RS06405	COG0346	lactoylglutathione lyase activity
CO687_RS06410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO687_RS06420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CO687_RS06425	COG0081	regulation of translation
CO687_RS06430	COG0531	amino acid
CO687_RS06435	COG1442	glycosyl transferase family 8
CO687_RS06440	COG0528	UMP kinase activity
CO687_RS06445	COG0233	cytoplasmic translational termination
CO687_RS06450	COG2996	Protein conserved in bacteria
CO687_RS06455	COG0768	penicillin binding
CO687_RS06460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CO687_RS06465	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO687_RS06470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO687_RS06475	COG1051	belongs to the nudix hydrolase family
CO687_RS06500	COG2884	Cell division ATP-binding protein ftsE
CO687_RS06505	COG2177	Part of the ABC transporter FtsEX involved in
CO687_RS06515	COG1199	ATP-dependent helicase activity
CO687_RS06515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO687_RS06525	COG0772	Belongs to the SEDS family
CO687_RS06530	COG0693	protein deglycase activity
CO687_RS06540	COG0187	DNA topoisomerase II activity
CO687_RS06545	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CO687_RS06555	COG0560	Phosphoserine phosphatase
CO687_RS06575	COG0148	phosphopyruvate hydratase activity
CO687_RS06595	COG2706	6-phosphogluconolactonase activity
CO687_RS06610	COG1136	(ABC) transporter
CO687_RS06615	COG0577	efflux transmembrane transporter activity
CO687_RS06620	COG0745	RESPONSE REGULATOR receiver
CO687_RS06625	COG3850	Histidine kinase
CO687_RS06625	COG5002	protein histidine kinase activity
CO687_RS06630	COG2936	dipeptidyl-peptidase activity
CO687_RS06635	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CO687_RS06640	COG1074	ATP-dependent DNA helicase activity
CO687_RS06650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CO687_RS06655	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CO687_RS06660	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CO687_RS06665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CO687_RS06670	COG0131	Imidazoleglycerol-phosphate dehydratase
CO687_RS06675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CO687_RS06680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CO687_RS06685	COG0107	imidazoleglycerol-phosphate synthase activity
CO687_RS06690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CO687_RS06695	COG0140	phosphoribosyl-ATP diphosphatase activity
CO687_RS06705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO687_RS06710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO687_RS06715	COG4109	DRTGG domain
CO687_RS06720	COG0024	Methionine aminopeptidase
CO687_RS06730	COG1846	Transcriptional regulator
CO687_RS06745	COG2246	polysaccharide biosynthetic process
CO687_RS06750	COG4708	membrane
CO687_RS06755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CO687_RS06760	COG1597	lipid kinase activity
CO687_RS06765	COG1523	belongs to the glycosyl hydrolase 13 family
CO687_RS06780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO687_RS06785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO687_RS06790	COG0335	large ribosomal subunit rRNA binding
CO687_RS06845	COG1368	sulfuric ester hydrolase activity
CO687_RS06850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CO687_RS06855	COG0710	3-dehydroquinate dehydratase activity
CO687_RS06860	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO687_RS06865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CO687_RS06875	COG0287	Prephenate dehydrogenase
CO687_RS06880	COG3679	Belongs to the UPF0342 family
CO687_RS06890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CO687_RS06895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CO687_RS06900	COG0077	Prephenate dehydratase
CO687_RS06910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO687_RS06925	COG1132	(ABC) transporter
CO687_RS06975	COG0366	Alpha amylase catalytic
CO687_RS07010	COG1131	(ABC) transporter
CO687_RS07020	COG0205	6-phosphofructokinase activity
CO687_RS07025	COG0469	pyruvate kinase activity
CO687_RS07035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CO687_RS07050	COG2873	o-acetylhomoserine
CO687_RS07065	COG1132	(ABC) transporter
CO687_RS07065	COG2375	cellular response to nickel ion
CO687_RS07070	COG1132	(ABC) transporter
CO687_RS07075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO687_RS07085	COG0647	UMP catabolic process
CO687_RS07105	COG0228	four-way junction DNA binding
CO687_RS07120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO687_RS07125	COG0569	domain protein
CO687_RS07140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CO687_RS07145	COG0336	Belongs to the RNA methyltransferase TrmD family
CO687_RS07150	COG3443	Belongs to the bacterial solute-binding protein 9 family
CO687_RS07150	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO687_RS07160	COG2195	Cleaves the N-terminal amino acid of tripeptides
CO687_RS07175	COG1272	protein, Hemolysin III
CO687_RS07185	COG3022	response to hydroperoxide
CO687_RS07190	COG0431	NADPH-dependent FMN reductase
CO687_RS07195	COG1846	Transcriptional regulator
CO687_RS07205	COG0436	Aminotransferase
CO687_RS07225	COG0017	Asparaginyl-tRNA synthetase
CO687_RS07240	COG1132	(ABC) transporter
CO687_RS07245	COG0488	(ABC) transporter
CO687_RS07250	COG0492	ferredoxin-NADP+ reductase activity
CO687_RS07255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO687_RS07260	COG3759	membrane
CO687_RS07285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CO687_RS07290	COG1970	mechanosensitive ion channel activity
CO687_RS07295	COG0358	DNA primase activity
CO687_RS07300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO687_RS07305	COG2151	metal-sulfur cluster biosynthetic enzyme
CO687_RS07330	COG1346	cytolysis
CO687_RS07340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CO687_RS07345	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CO687_RS07350	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CO687_RS07355	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CO687_RS07360	COG0038	chloride channel
CO687_RS07370	COG0813	purine-nucleoside phosphorylase activity
CO687_RS07400	COG0543	2 iron, 2 sulfur cluster binding
CO687_RS07405	COG0167	dihydroorotate dehydrogenase activity
CO687_RS07410	COG0284	orotidine-5'-phosphate decarboxylase activity
CO687_RS07415	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CO687_RS07430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CO687_RS07435	COG1051	belongs to the nudix hydrolase family
CO687_RS07445	COG0737	Belongs to the 5'-nucleotidase family
CO687_RS07450	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CO687_RS07455	COG0187	DNA topoisomerase II activity
CO687_RS07470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CO687_RS07475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO687_RS07495	COG0539	negative regulation of cytoplasmic translation
CO687_RS07510	COG0039	L-malate dehydrogenase activity
CO687_RS07515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CO687_RS07520	COG3764	Sortase (surface protein transpeptidase)
CO687_RS07525	COG2003	Belongs to the UPF0758 family
CO687_RS07545	COG1104	cysteine desulfurase activity
CO687_RS07550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO687_RS07560	COG2357	RelA SpoT domain protein
CO687_RS07565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CO687_RS07570	COG0564	pseudouridine synthase activity
CO687_RS07575	COG0280	phosphate acetyltransferase
CO687_RS07580	COG1194	a g-specific adenine glycosylase
CO687_RS07595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO687_RS07600	COG4684	Psort location CytoplasmicMembrane, score
CO687_RS07605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO687_RS07620	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO687_RS07625	COG1247	-acetyltransferase
CO687_RS07645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO687_RS07650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO687_RS07665	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO687_RS07670	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO687_RS07675	COG3711	transcriptional antiterminator
CO687_RS07680	COG0110	maltose O-acetyltransferase activity
CO687_RS07685	COG0758	DNA mediated transformation
CO687_RS07690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO687_RS07705	COG0135	phosphoribosylanthranilate isomerase activity
CO687_RS07710	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CO687_RS07715	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO687_RS07720	COG0222	ribosome binding
CO687_RS07785	COG1114	Component of the transport system for branched-chain amino acids
CO687_RS07815	COG0785	Cytochrome C biogenesis protein
CO687_RS07830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO687_RS07830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO687_RS07835	COG4753	response regulator
CO687_RS07835	COG2207	Transcriptional regulator
CO687_RS07840	COG2972	Histidine kinase
CO687_RS07845	COG0785	Cytochrome C biogenesis protein
CO687_RS07850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO687_RS07855	COG3976	FMN-binding domain protein
CO687_RS07855	COG0431	NADPH-dependent FMN reductase
CO687_RS07855	COG1053	succinate dehydrogenase
CO687_RS07880	COG2822	iron ion transport
CO687_RS07885	COG2837	iron assimilation
CO687_RS07890	COG0672	)-iron permease
CO687_RS07895	COG0805	protein transport
CO687_RS07905	COG0534	Mate efflux family protein
CO687_RS07910	COG0516	GMP reductase activity
CO687_RS07915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO687_RS07920	COG2233	PERMEase
CO687_RS07925	COG1942	4-Oxalocrotonate Tautomerase
CO687_RS07930	COG1435	thymidine kinase activity
CO687_RS07935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CO687_RS07940	COG2890	protein-(glutamine-N5) methyltransferase activity
CO687_RS07945	COG0009	L-threonylcarbamoyladenylate synthase
CO687_RS07950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO687_RS07960	COG0741	lytic transglycosylase activity
CO687_RS07970	COG1940	carbohydrate kinase activity
CO687_RS07975	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CO687_RS07985	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO687_RS07995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CO687_RS08000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CO687_RS08005	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO687_RS08005	COG1388	LysM domain
CO687_RS08015	COG2382	esterase
CO687_RS08025	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO687_RS08030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CO687_RS08035	COG0022	dehydrogenase e1 component
CO687_RS08040	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO687_RS08045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO687_RS08050	COG0095	Lipoate-protein ligase
CO687_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
CO687_RS08060	COG4974	Belongs to the 'phage' integrase family
CO687_RS08075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO687_RS08085	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CO687_RS08090	COG2188	Transcriptional regulator
CO687_RS08100	COG0488	(ABC) transporter
CO687_RS08105	COG0617	tRNA 3'-terminal CCA addition
CO687_RS08110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CO687_RS08115	COG1307	EDD domain protein, DegV family
CO687_RS08125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO687_RS08125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO687_RS08125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO687_RS08130	COG1105	Belongs to the carbohydrate kinase PfkB family
CO687_RS08135	COG1349	DNA-binding transcription factor activity
CO687_RS08145	COG0540	Belongs to the ATCase OTCase family
CO687_RS08155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CO687_RS08165	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO687_RS08170	COG0505	Belongs to the CarA family
CO687_RS08175	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CO687_RS08185	COG2824	Alkylphosphonate utilization operon protein PhnA
CO687_RS08190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CO687_RS08195	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CO687_RS08200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CO687_RS08215	COG0564	pseudouridine synthase activity
CO687_RS08220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CO687_RS08225	COG0583	DNA-binding transcription factor activity
CO687_RS08240	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO687_RS08245	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO687_RS08250	COG3845	ABC transporter
CO687_RS08255	COG1744	ABC transporter substrate-binding protein PnrA-like
CO687_RS08260	COG0295	cytidine deaminase activity
CO687_RS08265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CO687_RS08270	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CO687_RS08275	COG2813	Specifically methylates the guanine in position
CO687_RS08280	COG1072	(Pantothenic acid kinase))
CO687_RS08285	COG0268	Binds directly to 16S ribosomal RNA
CO687_RS08300	COG5002	protein histidine kinase activity
CO687_RS08305	COG0745	RESPONSE REGULATOR receiver
CO687_RS08325	COG1396	sequence-specific DNA binding
CO687_RS08365	COG0704	Plays a role in the regulation of phosphate uptake
CO687_RS08370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO687_RS08375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO687_RS08380	COG0581	inorganic phosphate transmembrane transporter activity
CO687_RS08385	COG0573	inorganic phosphate transmembrane transporter activity
CO687_RS08390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CO687_RS08395	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CO687_RS08395	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO687_RS08400	COG0483	inositol monophosphate 1-phosphatase activity
CO687_RS08405	COG4476	Belongs to the UPF0223 family
CO687_RS08410	COG1393	Belongs to the ArsC family
CO687_RS08415	COG0196	riboflavin kinase activity
CO687_RS08420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO687_RS08440	COG1827	regulation of RNA biosynthetic process
CO687_RS08470	COG0456	acetyltransferase
CO687_RS08480	COG0556	nucleotide-excision repair
CO687_RS08485	COG0765	amino acid transport
CO687_RS08490	COG1126	abc transporter atp-binding protein
CO687_RS08495	COG0346	lactoylglutathione lyase activity
CO687_RS08500	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO687_RS08505	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO687_RS08515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CO687_RS08535	COG1368	sulfuric ester hydrolase activity
CO687_RS08540	COG3754	Rhamnan synthesis protein F
CO687_RS08570	COG1091	dTDP-4-dehydrorhamnose reductase activity
CO687_RS08575	COG0463	Glycosyl transferase, family 2
CO687_RS08605	COG0463	Glycosyl transferase, family 2
CO687_RS08615	COG1088	dTDP-glucose 4,6-dehydratase activity
CO687_RS08625	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CO687_RS08635	COG1051	belongs to the nudix hydrolase family
CO687_RS08640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO687_RS08645	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CO687_RS08650	COG2384	SAM-dependent methyltransferase
CO687_RS08655	COG0625	glutathione transferase activity
CO687_RS08665	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CO687_RS08670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO687_RS08685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CO687_RS08685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CO687_RS08705	COG0300	oxidoreductase activity
CO687_RS08710	COG1234	tRNA 3'-trailer cleavage
CO687_RS08720	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CO687_RS08725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CO687_RS08735	COG2814	Major facilitator Superfamily
CO687_RS08745	COG2378	regulation of single-species biofilm formation
CO687_RS08750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO687_RS08770	COG0765	amino acid transport
CO687_RS08775	COG1126	abc transporter atp-binding protein
CO687_RS08780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO687_RS08785	COG2131	deaminase
CO687_RS08870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO687_RS08875	COG1132	(ABC) transporter
CO687_RS08880	COG1132	(ABC) transporter
CO687_RS08885	COG2315	Protein conserved in bacteria
CO687_RS08890	COG3142	Participates in the control of copper homeostasis
CO687_RS08905	COG1481	regulation of sporulation
CO687_RS08910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CO687_RS08915	COG1660	Displays ATPase and GTPase activities
CO687_RS08920	COG0251	oxidation-reduction process
CO687_RS08930	COG0572	uridine kinase
CO687_RS08935	COG0673	inositol 2-dehydrogenase activity
CO687_RS08945	COG0726	polysaccharide deacetylase
CO687_RS08950	COG0596	Alpha beta hydrolase
CO687_RS08955	COG1363	Peptidase, m42
CO687_RS08975	COG3583	domain protein
CO687_RS08975	COG3583	domain protein
CO687_RS08985	COG3848	Pyruvate phosphate dikinase
CO687_RS08985	COG0574	Belongs to the PEP-utilizing enzyme family
CO687_RS08995	COG0688	phosphatidylethanolamine metabolic process
CO687_RS09000	COG1183	phosphatidylcholine synthase activity
CO687_RS09015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO687_RS09025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO687_RS09030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO687_RS09035	COG1609	Transcriptional regulator
CO687_RS09040	COG1230	cation diffusion facilitator family transporter
CO687_RS09075	COG1122	ATPase activity
CO687_RS09080	COG1122	ATPase activity
CO687_RS09085	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CO687_RS09095	COG1174	glycine betaine transport
CO687_RS09100	COG0517	IMP dehydrogenase activity
CO687_RS09100	COG1125	glycine betaine transport
CO687_RS09110	COG1846	Transcriptional regulator
CO687_RS09120	COG0066	3-isopropylmalate dehydratase activity
CO687_RS09125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CO687_RS09150	COG1609	Transcriptional regulator
CO687_RS09165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO687_RS09170	COG1956	GAF domain-containing protein
CO687_RS09175	COG0596	Alpha beta hydrolase
CO687_RS09185	COG3620	sequence-specific DNA binding
CO687_RS09195	COG2813	Specifically methylates the guanine in position
CO687_RS09210	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO687_RS09220	COG4932	domain protein
CO687_RS09225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO687_RS09235	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CO687_RS09240	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO687_RS09245	COG3442	glutamine amidotransferase
CO687_RS09270	COG0488	(ABC) transporter
CO687_RS09280	COG1136	(ABC) transporter
CO687_RS09285	COG0577	efflux transmembrane transporter activity
CO687_RS09315	COG0072	phenylalanine-tRNA ligase activity
CO687_RS09315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO687_RS09320	COG0456	acetyltransferase
CO687_RS09330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO687_RS09345	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CO687_RS09355	COG3527	Alpha-acetolactate decarboxylase
CO687_RS09365	COG0628	permease
CO687_RS09370	COG0716	FMN binding
CO687_RS09375	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO687_RS09385	COG0254	rRNA binding
CO687_RS09415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO687_RS09420	COG1063	alcohol dehydrogenase
CO687_RS09440	COG1573	uracil-dna glycosylase
CO687_RS09545	COG0322	excinuclease ABC activity
CO687_RS09550	COG1011	Hydrolase
CO687_RS09560	COG3708	Transcriptional regulator
CO687_RS09560	COG2207	Transcriptional regulator
CO687_RS09575	COG0481	GTPase activity
CO687_RS09580	COG0561	phosphatase activity
CO687_RS09590	COG0425	Belongs to the sulfur carrier protein TusA family
CO687_RS09590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO687_RS09595	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CO687_RS09605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO687_RS09615	COG0301	tRNA thio-modification
CO687_RS09620	COG1104	cysteine desulfurase activity
CO687_RS09625	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CO687_RS09630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CO687_RS09635	COG0517	IMP dehydrogenase activity
CO687_RS09640	COG0574	Belongs to the PEP-utilizing enzyme family
CO687_RS09640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO687_RS09655	COG1177	transmembrane transport
CO687_RS09660	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO687_RS09665	COG3842	ATPase activity
CO687_RS09670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CO687_RS09680	COG0083	homoserine kinase activity
CO687_RS09700	COG1131	(ABC) transporter
CO687_RS09705	COG4187	Peptidase family M20/M25/M40
CO687_RS09725	COG3091	SprT-like family
CO687_RS09730	COG2183	response to ionizing radiation
CO687_RS09740	COG0701	Predicted permease
CO687_RS09745	COG3689	TIGRFAM TIGR03943 family protein
CO687_RS09750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CO687_RS09755	COG0552	protein localization to endoplasmic reticulum
CO687_RS09760	COG0561	phosphatase activity
CO687_RS09765	COG0561	phosphatase activity
CO687_RS09770	COG1196	nuclear chromosome segregation
CO687_RS09775	COG0571	ribonuclease III activity
CO687_RS09780	COG2832	Protein of unknown function (DUF454)
CO687_RS09785	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CO687_RS09795	COG0745	RESPONSE REGULATOR receiver
CO687_RS09800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO687_RS09815	COG0438	transferase activity, transferring glycosyl groups
CO687_RS09825	COG1609	Transcriptional regulator
CO687_RS09830	COG0006	proline dipeptidase activity
CO687_RS09840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO687_RS09855	COG2819	hydrolase of the alpha beta superfamily
CO687_RS09870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO687_RS09880	COG0149	triose-phosphate isomerase activity
CO687_RS09885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO687_RS09890	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CO687_RS09895	COG0772	Belongs to the SEDS family
CO687_RS09900	COG0386	Belongs to the glutathione peroxidase family
CO687_RS09915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CO687_RS09925	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CO687_RS09930	COG0577	efflux transmembrane transporter activity
CO687_RS09935	COG1136	(ABC) transporter
CO687_RS09945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO687_RS09950	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CO687_RS09955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO687_RS09960	COG1268	BioY protein
CO687_RS09965	COG4443	Transcriptional Coactivator p15 (PC4)
CO687_RS09975	COG0826	peptidase U32
CO687_RS10005	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CO687_RS10010	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CO687_RS10020	COG1983	PspC domain protein
CO687_RS10025	COG2514	catechol 2,3-dioxygenase activity
CO687_RS10030	COG1959	2 iron, 2 sulfur cluster binding
CO687_RS10060	COG0577	efflux transmembrane transporter activity
CO687_RS10060	COG1136	(ABC) transporter
CO687_RS10065	COG1309	transcriptional regulator
CO687_RS10090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CO687_RS10095	COG0557	exoribonuclease II activity
CO687_RS10105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO687_RS10110	COG2814	Major facilitator Superfamily
CO687_RS10115	COG0237	dephospho-CoA kinase activity
CO687_RS10120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CO687_RS10130	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CO687_RS10135	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CO687_RS10140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CO687_RS10150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO687_RS10155	COG0686	Belongs to the AlaDH PNT family
CO687_RS10165	COG1702	phosphate starvation-inducible protein PhoH
CO687_RS10170	COG4479	Belongs to the UPF0346 family
CO687_RS10175	COG0588	phosphoglycerate mutase activity
CO687_RS10180	COG0735	belongs to the Fur family
CO687_RS10190	COG1307	EDD domain protein, DegV family
CO687_RS10195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CO687_RS10200	COG0497	DNA recombination
CO687_RS10205	COG1438	arginine binding
CO687_RS10210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CO687_RS10220	COG1722	exodeoxyribonuclease VII activity
CO687_RS10225	COG1570	exodeoxyribonuclease VII activity
CO687_RS10235	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CO687_RS10245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO687_RS10250	COG4703	Protein of unknown function (DUF1797)
CO687_RS10255	COG0542	response to heat
CO687_RS10265	COG2378	regulation of single-species biofilm formation
CO687_RS10270	COG0406	alpha-ribazole phosphatase activity
CO687_RS10270	COG0494	nUDIX hydrolase
CO687_RS10290	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO687_RS10295	COG3599	regulation of cell shape
CO687_RS10300	COG2302	S4 RNA-binding domain
CO687_RS10310	COG1799	cell septum assembly
CO687_RS10315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CO687_RS10320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CO687_RS10330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CO687_RS10335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CO687_RS10340	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CO687_RS10350	COG1217	gtp-binding protein TYPA
CO687_RS10355	COG1187	pseudouridine synthase activity
CO687_RS10360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO687_RS10385	COG0159	tryptophan synthase activity
CO687_RS10395	COG0135	phosphoribosylanthranilate isomerase activity
CO687_RS10400	COG0134	indole-3-glycerol-phosphate synthase activity
CO687_RS10405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CO687_RS10410	COG0512	Glutamine amidotransferase of anthranilate synthase
CO687_RS10415	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CO687_RS10425	COG0133	tryptophan synthase activity
CO687_RS10435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CO687_RS10440	COG4470	Protein conserved in bacteria
CO687_RS10445	COG3480	Lon protease (S16) C-terminal proteolytic domain
CO687_RS10450	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CO687_RS10455	COG0742	ribosomal rna small subunit methyltransferase
CO687_RS10465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO687_RS10470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII