locus-tag	class	description
RN86_RS00075	COG1040	competence protein
RN86_RS00080	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
RN86_RS00085	COG1739	Uncharacterized protein family UPF0029
RN86_RS00095	COG1185	polyribonucleotide nucleotidyltransferase activity
RN86_RS00110	COG4585	Histidine kinase
RN86_RS00120	COG2815	serine threonine protein kinase
RN86_RS00120	COG0515	serine threonine protein kinase
RN86_RS00125	COG0631	protein serine/threonine phosphatase activity
RN86_RS00130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RN86_RS00130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RN86_RS00135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RN86_RS00140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RN86_RS00145	COG1758	RNA polymerase activity
RN86_RS00150	COG0194	GDP metabolic process
RN86_RS00155	COG1418	mRNA catabolic process
RN86_RS00160	COG1854	S-ribosylhomocysteine lyase activity
RN86_RS00170	COG0116	Belongs to the methyltransferase superfamily
RN86_RS00180	COG3599	regulation of cell shape
RN86_RS00185	COG4474	Belongs to the UPF0398 family
RN86_RS00190	COG3331	DNA recombination
RN86_RS00195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RN86_RS00200	COG3579	cysteine-type endopeptidase activity
RN86_RS00205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RN86_RS00210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RN86_RS00215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RN86_RS00220	COG0492	ferredoxin-NADP+ reductase activity
RN86_RS00230	COG1126	abc transporter atp-binding protein
RN86_RS00240	COG0513	Belongs to the DEAD box helicase family
RN86_RS00245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RN86_RS00250	COG0768	penicillin binding
RN86_RS00260	COG0275	rRNA processing
RN86_RS00275	COG4224	UPF0291 protein
RN86_RS00280	COG0751	glycine-tRNA ligase activity
RN86_RS00290	COG0752	glycyl-tRNA synthetase alpha subunit
RN86_RS00300	COG1064	alcohol dehydrogenase
RN86_RS00325	COG0732	type I restriction modification DNA specificity domain
RN86_RS00335	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RN86_RS00345	COG0656	L-ascorbic acid biosynthetic process
RN86_RS00360	COG1283	sodium-dependent phosphate transmembrane transporter activity
RN86_RS00365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RN86_RS00370	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RN86_RS00380	COG2740	Nucleic-acid-binding protein implicated in transcription termination
RN86_RS00385	COG0195	Participates in both transcription termination and antitermination
RN86_RS00390	COG0779	Required for maturation of 30S ribosomal subunits
RN86_RS00395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RN86_RS00410	COG1131	(ABC) transporter
RN86_RS00415	COG0537	adenosine 5'-monophosphoramidase activity
RN86_RS00425	COG1316	TRANSCRIPTIONal
RN86_RS00435	COG0802	atpase or kinase
RN86_RS00440	COG2252	PERMEase
RN86_RS00450	COG0561	phosphatase activity
RN86_RS00455	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RN86_RS00460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RN86_RS00465	COG0440	acetolactate synthase activity
RN86_RS00470	COG0028	Belongs to the TPP enzyme family
RN86_RS00485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RN86_RS00490	COG1254	Belongs to the acylphosphatase family
RN86_RS00505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RN86_RS00510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RN86_RS00520	COG0456	acetyltransferase
RN86_RS00525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RN86_RS00535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RN86_RS00540	COG1160	GTP binding
RN86_RS00550	COG1484	DNA-dependent DNA replication
RN86_RS00560	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RN86_RS00585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RN86_RS00585	COG1263	PTS System
RN86_RS00585	COG2190	(PTS) system
RN86_RS00590	COG0745	RESPONSE REGULATOR receiver
RN86_RS00595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RN86_RS00600	COG2268	Band 7 protein
RN86_RS00620	COG0366	Alpha amylase catalytic
RN86_RS00620	COG5263	repeat protein
RN86_RS00620	COG0366	Alpha amylase catalytic
RN86_RS00620	COG5263	repeat protein
RN86_RS00625	COG1396	sequence-specific DNA binding
RN86_RS00630	COG0501	Belongs to the peptidase M48B family
RN86_RS00635	COG1704	LemA family
RN86_RS00640	COG1309	transcriptional regulator
RN86_RS00650	COG0357	Ribosomal RNA small subunit methyltransferase G
RN86_RS00665	COG1122	ATPase activity
RN86_RS00675	COG2357	RelA SpoT domain protein
RN86_RS00680	COG0745	RESPONSE REGULATOR receiver
RN86_RS00715	COG1054	Belongs to the UPF0176 family
RN86_RS00750	COG4720	Psort location CytoplasmicMembrane, score
RN86_RS00760	COG1129	ABC transporter
RN86_RS00775	COG1132	(ABC) transporter
RN86_RS00780	COG1132	(ABC) transporter
RN86_RS00790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RN86_RS00795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RN86_RS00800	COG1464	Belongs to the NlpA lipoprotein family
RN86_RS00805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RN86_RS00810	COG1473	amidohydrolase
RN86_RS00820	COG0217	transcriptional regulatory protein
RN86_RS00830	COG1323	Belongs to the UPF0348 family
RN86_RS00835	COG2226	methyltransferase
RN86_RS00840	COG0799	negative regulation of ribosome biogenesis
RN86_RS00845	COG1713	HD superfamily hydrolase involved in NAD metabolism
RN86_RS00850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RN86_RS00855	COG1534	Rna-binding protein
RN86_RS00860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RN86_RS00865	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
RN86_RS00885	COG1063	alcohol dehydrogenase
RN86_RS00895	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RN86_RS00900	COG0154	amidase activity
RN86_RS00905	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RN86_RS00910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RN86_RS00915	COG1335	isochorismatase
RN86_RS00920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
RN86_RS00930	COG0436	Aminotransferase
RN86_RS00935	COG0589	response to stress
RN86_RS00940	COG0561	phosphatase activity
RN86_RS00945	COG0252	asparaginase activity
RN86_RS00950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RN86_RS00955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RN86_RS00960	COG0736	holo-[acyl-carrier-protein] synthase activity
RN86_RS00965	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RN86_RS00980	COG3343	RNA polymerase activity
RN86_RS00985	COG0544	peptidyl-prolyl cis-trans isomerase activity
RN86_RS00990	COG4475	Protein of unknown function (DUF436)
RN86_RS00995	COG4720	Psort location CytoplasmicMembrane, score
RN86_RS01000	COG0351	phosphomethylpyrimidine kinase
RN86_RS01005	COG3064	Membrane
RN86_RS01010	COG0101	tRNA pseudouridine synthase activity
RN86_RS01020	COG3583	domain protein
RN86_RS01020	COG3525	Glycosyl hydrolase, family 20, catalytic domain
RN86_RS01020	COG3064	Membrane
RN86_RS01025	COG0484	heat shock protein binding
RN86_RS01040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RN86_RS01045	COG1420	regulation of RNA biosynthetic process
RN86_RS01080	COG1876	peptidase activity
RN86_RS01085	COG0588	phosphoglycerate mutase activity
RN86_RS01095	COG2848	UPF0210 protein
RN86_RS01100	COG3830	Belongs to the UPF0237 family
RN86_RS01110	COG3804	dihydrodipicolinate reductase
RN86_RS01115	COG4978	Transcriptional regulator
RN86_RS01115	COG0789	Transcriptional regulator
RN86_RS01120	COG1621	beta-fructofuranosidase activity
RN86_RS01120	COG3583	domain protein
RN86_RS01120	COG5492	domain, Protein
RN86_RS01130	COG1301	dicarboxylic acid transport
RN86_RS01135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RN86_RS01150	COG2323	membrane
RN86_RS01155	COG3237	CsbD-like
RN86_RS01170	COG3290	protein histidine kinase activity
RN86_RS01210	COG1396	sequence-specific DNA binding
RN86_RS01245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RN86_RS01250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RN86_RS01265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RN86_RS01275	COG0531	amino acid
RN86_RS01280	COG3842	ATPase activity
RN86_RS01290	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RN86_RS01295	COG0215	cysteine-tRNA ligase activity
RN86_RS01315	COG1045	serine acetyltransferase
RN86_RS01320	COG1185	polyribonucleotide nucleotidyltransferase activity
RN86_RS01330	COG0477	Major facilitator Superfamily
RN86_RS01335	COG1164	Oligoendopeptidase f
RN86_RS01350	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RN86_RS01355	COG3118	belongs to the thioredoxin family
RN86_RS01370	COG2267	carboxylic ester hydrolase activity
RN86_RS01425	COG1187	pseudouridine synthase activity
RN86_RS01435	COG0242	peptide deformylase activity
RN86_RS01455	COG1404	Belongs to the peptidase S8 family
RN86_RS01455	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RN86_RS01480	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RN86_RS01490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RN86_RS01505	COG1131	(ABC) transporter
RN86_RS01530	COG1131	(ABC) transporter
RN86_RS01550	COG5002	protein histidine kinase activity
RN86_RS01555	COG0745	RESPONSE REGULATOR receiver
RN86_RS01560	COG2723	6-phospho-beta-galactosidase activity
RN86_RS01570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RN86_RS01580	COG0028	Belongs to the TPP enzyme family
RN86_RS01605	COG0561	phosphatase activity
RN86_RS01610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RN86_RS01620	COG2207	Transcriptional regulator
RN86_RS01640	COG2190	(PTS) system
RN86_RS01640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RN86_RS01640	COG1263	PTS System
RN86_RS01655	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RN86_RS01655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RN86_RS01660	COG0167	dihydroorotate dehydrogenase activity
RN86_RS01665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RN86_RS01695	COG5504	Zn-dependent protease
RN86_RS01700	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
RN86_RS01710	COG0668	transmembrane transport
RN86_RS01715	COG0531	amino acid
RN86_RS01725	COG0583	DNA-binding transcription factor activity
RN86_RS01735	COG3118	belongs to the thioredoxin family
RN86_RS01750	COG1193	negative regulation of DNA recombination
RN86_RS01765	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RN86_RS01770	COG0681	Belongs to the peptidase S26 family
RN86_RS01775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RN86_RS01780	COG1309	transcriptional regulator
RN86_RS01800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RN86_RS01805	COG1882	Formate acetyltransferase
RN86_RS01820	COG3425	synthase
RN86_RS01830	COG1304	FMN binding
RN86_RS01850	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RN86_RS01865	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RN86_RS01910	COG2081	HI0933 family
RN86_RS01915	COG0789	Transcriptional regulator
RN86_RS01925	COG2226	methyltransferase
RN86_RS01940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RN86_RS01950	COG1214	PFAM Peptidase M22, glycoprotease
RN86_RS01955	COG5503	Protein of unknown function (DUF1447)
RN86_RS01970	COG1309	transcriptional regulator
RN86_RS01985	COG0174	glutamine synthetase
RN86_RS01990	COG0789	Transcriptional regulator
RN86_RS02000	COG3942	CHAP domain
RN86_RS02010	COG0126	phosphoglycerate kinase activity
RN86_RS02025	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RN86_RS02030	COG0049	tRNA binding
RN86_RS02035	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RN86_RS02045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN86_RS02050	COG3481	metal-dependent phosphohydrolase, HD sub domain
RN86_RS02060	COG1564	THIamine pyrophosphokinase
RN86_RS02070	COG1162	GTPase activity
RN86_RS02090	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RN86_RS02115	COG0084	hydrolase, TatD family'
RN86_RS02135	COG3655	Transcriptional regulator
RN86_RS02145	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RN86_RS02160	COG1847	R3H domain protein
RN86_RS02170	COG0594	ribonuclease P activity
RN86_RS02175	COG0165	Argininosuccinate lyase
RN86_RS02180	COG0137	argininosuccinate synthase activity
RN86_RS02185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RN86_RS02200	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RN86_RS02210	COG0756	dUTP diphosphatase activity
RN86_RS02220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RN86_RS02225	COG1132	(ABC) transporter
RN86_RS02230	COG1132	(ABC) transporter
RN86_RS02235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RN86_RS02240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RN86_RS02255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RN86_RS02260	COG1473	amidohydrolase
RN86_RS02265	COG2171	N-acyltransferase activity
RN86_RS02285	COG0166	Belongs to the GPI family
RN86_RS02300	COG0343	queuine tRNA-ribosyltransferase activity
RN86_RS02325	COG1832	CoA-binding protein
RN86_RS02330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN86_RS02330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN86_RS02340	COG0546	phosphoglycolate phosphatase activity
RN86_RS02360	COG1394	ATPase activity, coupled to movement of substances
RN86_RS02365	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
RN86_RS02370	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
RN86_RS02380	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
RN86_RS02385	COG1527	subunit (C
RN86_RS02395	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN86_RS02400	COG1269	ATP hydrolysis coupled proton transport
RN86_RS02415	COG1737	Transcriptional regulator
RN86_RS02425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RN86_RS02435	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
RN86_RS02440	COG1012	belongs to the aldehyde dehydrogenase family
RN86_RS02440	COG1454	alcohol dehydrogenase
RN86_RS02445	COG2755	lipolytic protein G-D-S-L family
RN86_RS02445	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RN86_RS02455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RN86_RS02465	COG2255	four-way junction helicase activity
RN86_RS02475	COG0058	SHG alpha-glucan phosphorylase activity
RN86_RS02480	COG1640	4-alpha-glucanotransferase
RN86_RS02485	COG2182	Extracellular solute-binding protein
RN86_RS02490	COG1175	transmembrane transport
RN86_RS02495	COG3833	ABC-type maltose transport systems, permease component
RN86_RS02500	COG5521	maltodextrose utilization protein MalA
RN86_RS02505	COG1609	Transcriptional regulator
RN86_RS02510	COG1523	belongs to the glycosyl hydrolase 13 family
RN86_RS02515	COG1780	Probably involved in ribonucleotide reductase function
RN86_RS02525	COG1011	Hydrolase
RN86_RS02530	COG1619	proteins homologs of microcin C7 resistance protein MccF
RN86_RS02550	COG1511	domain protein
RN86_RS02560	COG1230	cation diffusion facilitator family transporter
RN86_RS02570	COG2807	transmembrane transport
RN86_RS02580	COG1349	DNA-binding transcription factor activity
RN86_RS02720	COG4499	WXG100 protein secretion system (Wss), protein YukC
RN86_RS02750	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
RN86_RS02755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RN86_RS02760	COG1696	Membrane protein involved in D-alanine export
RN86_RS02795	COG2222	sugar isomerase
RN86_RS02805	COG3716	PTS system mannose fructose sorbose family IID component
RN86_RS02815	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RN86_RS02830	COG0138	bifunctional purine biosynthesis protein purh
RN86_RS02840	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RN86_RS02845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RN86_RS02855	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RN86_RS02860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RN86_RS02865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RN86_RS02870	COG0416	fatty acid biosynthetic process
RN86_RS02875	COG1381	Involved in DNA repair and RecF pathway recombination
RN86_RS02880	COG0436	Aminotransferase
RN86_RS02890	COG0305	Participates in initiation and elongation during chromosome replication
RN86_RS02895	COG0359	binds to the 23S rRNA
RN86_RS02905	COG0445	tRNA wobble uridine modification
RN86_RS02910	COG2095	MarC family integral membrane protein
RN86_RS02915	COG0482	sulfurtransferase activity
RN86_RS02925	COG1760	l-serine dehydratase
RN86_RS02930	COG1760	l-serine dehydratase
RN86_RS02935	COG0741	lytic transglycosylase activity
RN86_RS02940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RN86_RS02945	COG1122	ATPase activity
RN86_RS02950	COG1122	ATPase activity
RN86_RS02955	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RN86_RS02965	COG0612	Peptidase, M16
RN86_RS02970	COG0612	Peptidase, M16
RN86_RS02980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RN86_RS02985	COG0516	GMP reductase activity
RN86_RS02985	COG0517	IMP dehydrogenase activity
RN86_RS02990	COG0180	Tryptophanyl-tRNA synthetase
RN86_RS02995	COG0488	(ABC) transporter
RN86_RS03015	COG0592	DNA-directed DNA polymerase activity
RN86_RS03025	COG1475	DNA binding
RN86_RS03030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RN86_RS03035	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RN86_RS03070	COG0012	GTP binding
RN86_RS03075	COG0193	aminoacyl-tRNA hydrolase activity
RN86_RS03080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RN86_RS03085	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RN86_RS03105	COG0037	tRNA processing
RN86_RS03110	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RN86_RS03115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RN86_RS03290	COG1792	Involved in formation and maintenance of cell shape
RN86_RS03300	COG3942	CHAP domain
RN86_RS03305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RN86_RS03315	COG4509	Sortase family
RN86_RS03330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RN86_RS03335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RN86_RS03340	COG1116	anion transmembrane transporter activity
RN86_RS03345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RN86_RS03350	COG2274	protein secretion by the type I secretion system
RN86_RS03355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RN86_RS03360	COG3942	CHAP domain
RN86_RS03365	COG0151	Belongs to the GarS family
RN86_RS03375	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RN86_RS03395	COG1794	racemase activity, acting on amino acids and derivatives
RN86_RS03400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RN86_RS03405	COG2249	NAD(P)H dehydrogenase (quinone) activity
RN86_RS03445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RN86_RS03450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RN86_RS03455	COG0129	dihydroxy-acid dehydratase activity
RN86_RS03460	COG2151	metal-sulfur cluster biosynthetic enzyme
RN86_RS03465	COG0124	histidyl-tRNA synthetase
RN86_RS03480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RN86_RS03485	COG0018	arginyl-trna synthetase
RN86_RS03490	COG1438	arginine binding
RN86_RS03495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RN86_RS03515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RN86_RS03525	COG1395	domain, Protein
RN86_RS03530	COG0632	four-way junction helicase activity
RN86_RS03540	COG2818	Glycosylase
RN86_RS03545	COG1266	CAAX protease self-immunity
RN86_RS03555	COG1546	Belongs to the CinA family
RN86_RS03555	COG1058	Belongs to the CinA family
RN86_RS03560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RN86_RS03565	COG1393	Belongs to the ArsC family
RN86_RS03575	COG4472	Bacterial protein of unknown function (DUF965)
RN86_RS03580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RN86_RS03585	COG3906	Belongs to the UPF0473 family
RN86_RS03590	COG0285	dihydrofolate synthase activity
RN86_RS03600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RN86_RS03610	COG1328	CTP reductase activity
RN86_RS03625	COG0602	queuosine metabolic process
RN86_RS03635	COG4464	protein tyrosine phosphatase activity
RN86_RS03640	COG3944	biosynthesis protein
RN86_RS03655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RN86_RS03660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RN86_RS03665	COG1216	Glycosyl transferase, family 2
RN86_RS03675	COG3475	LICD family
RN86_RS03685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RN86_RS03710	COG0564	pseudouridine synthase activity
RN86_RS03715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RN86_RS03720	COG2321	neutral zinc metallopeptidase
RN86_RS03760	COG0052	Belongs to the universal ribosomal protein uS2 family
RN86_RS03765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RN86_RS03775	COG4463	regulation of RNA biosynthetic process
RN86_RS03790	COG3201	nicotinamide mononucleotide transporter
RN86_RS03805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RN86_RS03810	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RN86_RS03815	COG1397	ADP-ribosylglycohydrolase
RN86_RS03820	COG1181	Belongs to the D-alanine--D-alanine ligase family
RN86_RS03820	COG2918	glutathione biosynthetic process
RN86_RS03825	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RN86_RS03835	COG0051	transcription antitermination factor activity, RNA binding
RN86_RS03840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RN86_RS03845	COG0088	Forms part of the polypeptide exit tunnel
RN86_RS03850	COG0089	rRNA binding
RN86_RS03855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RN86_RS03860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RN86_RS03865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RN86_RS03870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RN86_RS03875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RN86_RS03880	COG0255	Belongs to the universal ribosomal protein uL29 family
RN86_RS03885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RN86_RS03890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RN86_RS03895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RN86_RS03900	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RN86_RS03905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RN86_RS03910	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RN86_RS03915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RN86_RS03925	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RN86_RS03930	COG1841	ribosomal large subunit assembly
RN86_RS03935	COG0200	Binds to the 23S rRNA
RN86_RS03940	COG0201	protein transport
RN86_RS03945	COG0563	adenylate kinase activity
RN86_RS03950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RN86_RS03955	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RN86_RS03960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RN86_RS03965	COG0202	RNA polymerase activity
RN86_RS03970	COG0203	ribosomal protein L17
RN86_RS04075	COG1846	Transcriptional regulator
RN86_RS04080	COG1121	(ABC) transporter
RN86_RS04085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RN86_RS04090	COG0803	Belongs to the bacterial solute-binding protein 9 family
RN86_RS04090	COG3443	Belongs to the bacterial solute-binding protein 9 family
RN86_RS04100	COG2217	Heavy metal translocating P-type atpase
RN86_RS04120	COG0500	methyltransferase
RN86_RS04125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RN86_RS04135	COG0085	RNA polymerase activity
RN86_RS04140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RN86_RS04150	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RN86_RS04155	COG1459	type II secretion system
RN86_RS04160	COG4537	Required for transformation and DNA binding
RN86_RS04190	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RN86_RS04200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RN86_RS04205	COG0285	dihydrofolate synthase activity
RN86_RS04210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RN86_RS04210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RN86_RS04215	COG1131	(ABC) transporter
RN86_RS04250	COG4868	Belongs to the UPF0371 family
RN86_RS04260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN86_RS04265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN86_RS04275	COG1363	Peptidase, m42
RN86_RS04285	COG4585	Histidine kinase
RN86_RS04290	COG2197	response regulator
RN86_RS04310	COG3715	PTS system
RN86_RS04315	COG3716	PTS system mannose fructose sorbose family IID component
RN86_RS04325	COG4120	Belongs to the binding-protein-dependent transport system permease family
RN86_RS04335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RN86_RS04355	COG0302	gtp cyclohydrolase
RN86_RS04360	COG0360	Binds together with S18 to 16S ribosomal RNA
RN86_RS04365	COG0629	single-stranded DNA binding
RN86_RS04370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RN86_RS04375	COG1309	transcriptional regulator
RN86_RS04380	COG1131	(ABC) transporter
RN86_RS04435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RN86_RS04440	COG0006	proline dipeptidase activity
RN86_RS04455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RN86_RS04465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RN86_RS04470	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
RN86_RS04475	COG1609	Transcriptional regulator
RN86_RS04480	COG1621	beta-fructofuranosidase activity
RN86_RS04485	COG2190	(PTS) system
RN86_RS04485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RN86_RS04485	COG1263	PTS System
RN86_RS04500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RN86_RS04505	COG4589	Belongs to the CDS family
RN86_RS04510	COG0750	zinc metalloprotease
RN86_RS04515	COG0442	prolyl-tRNA aminoacylation
RN86_RS04535	COG2176	DNA-directed DNA polymerase activity
RN86_RS04540	COG0464	growth
RN86_RS04545	COG2309	aminopeptidase activity
RN86_RS04555	COG2261	transglycosylase associated protein
RN86_RS04565	COG1132	(ABC) transporter
RN86_RS04575	COG3237	CsbD-like
RN86_RS04590	COG2261	transglycosylase associated protein
RN86_RS04595	COG3711	transcriptional antiterminator
RN86_RS04600	COG2855	membrane
RN86_RS04640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RN86_RS04655	COG0494	nUDIX hydrolase
RN86_RS04670	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RN86_RS04675	COG1396	sequence-specific DNA binding
RN86_RS04690	COG1490	D-aminoacyl-tRNA deacylase activity
RN86_RS04705	COG1673	EVE domain
RN86_RS04710	COG1846	Transcriptional regulator
RN86_RS04730	COG0010	Belongs to the arginase family
RN86_RS04740	COG2986	histidine ammonia-lyase
RN86_RS04745	COG0531	amino acid
RN86_RS04755	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RN86_RS04760	COG3404	Formiminotransferase-cyclodeaminase
RN86_RS04770	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RN86_RS04775	COG1228	amidohydrolase
RN86_RS04800	COG3590	peptidase
RN86_RS04830	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RN86_RS04835	COG1447	Phosphotransferase system cellobiose-specific component IIA
RN86_RS04840	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RN86_RS04850	COG4989	oxidoreductase activity
RN86_RS04860	COG0495	leucyl-tRNA aminoacylation
RN86_RS04915	COG1063	alcohol dehydrogenase
RN86_RS04930	COG0300	oxidoreductase activity
RN86_RS04940	COG1131	(ABC) transporter
RN86_RS04950	COG1309	transcriptional regulator
RN86_RS04965	COG3537	Alpha-1,2-mannosidase
RN86_RS04975	COG0383	alpha-mannosidase activity
RN86_RS04990	COG4209	transmembrane transport
RN86_RS04995	COG0395	ABC-type sugar transport system, permease component
RN86_RS05000	COG1653	transport
RN86_RS05010	COG2972	Histidine kinase
RN86_RS05015	COG2207	Transcriptional regulator
RN86_RS05015	COG4753	response regulator
RN86_RS05020	COG2723	6-phospho-beta-galactosidase activity
RN86_RS05030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RN86_RS05040	COG1940	carbohydrate kinase activity
RN86_RS05045	COG0242	peptide deformylase activity
RN86_RS05065	COG1132	(ABC) transporter
RN86_RS05070	COG1482	cell wall glycoprotein biosynthetic process
RN86_RS05075	COG0504	CTP synthase activity
RN86_RS05090	COG0191	fructose-bisphosphate aldolase activity
RN86_RS05095	COG4555	ABC transporter
RN86_RS05135	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RN86_RS05145	COG1461	Dihydroxyacetone kinase
RN86_RS05150	COG1131	(ABC) transporter
RN86_RS05160	COG4585	Histidine kinase
RN86_RS05165	COG2197	response regulator
RN86_RS05180	COG1126	abc transporter atp-binding protein
RN86_RS05185	COG0765	amino acid transport
RN86_RS05195	COG1968	undecaprenyl-diphosphatase activity
RN86_RS05200	COG4862	establishment of competence for transformation
RN86_RS05205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RN86_RS05215	COG0719	Fe-S assembly protein
RN86_RS05220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RN86_RS05230	COG0719	Fe-S assembly protein
RN86_RS05240	COG4166	transmembrane transport
RN86_RS05245	COG4166	transmembrane transport
RN86_RS05250	COG4166	transmembrane transport
RN86_RS05255	COG4166	transmembrane transport
RN86_RS05260	COG0601	transmembrane transport
RN86_RS05265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN86_RS05270	COG0444	Belongs to the ABC transporter superfamily
RN86_RS05275	COG4608	Belongs to the ABC transporter superfamily
RN86_RS05310	COG0527	aspartate kinase activity
RN86_RS05315	COG1024	Enoyl-CoA hydratase
RN86_RS05325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RN86_RS05335	COG2070	2-Nitropropane dioxygenase
RN86_RS05340	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RN86_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
RN86_RS05350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RN86_RS05360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RN86_RS05365	COG0439	Biotin carboxylase
RN86_RS05370	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RN86_RS05375	COG0825	malonyl-CoA metabolic process
RN86_RS05395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RN86_RS05400	COG1309	transcriptional regulator
RN86_RS05420	COG3716	PTS system mannose fructose sorbose family IID component
RN86_RS05425	COG3715	PTS system
RN86_RS05445	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RN86_RS05450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RN86_RS05465	COG4974	Belongs to the 'phage' integrase family
RN86_RS05470	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RN86_RS05475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RN86_RS05480	COG1187	pseudouridine synthase activity
RN86_RS05485	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RN86_RS05500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RN86_RS05505	COG0569	domain protein
RN86_RS05515	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
RN86_RS05520	COG0671	phosphoesterase, PA-phosphatase related
RN86_RS05530	COG1242	4 iron, 4 sulfur cluster binding
RN86_RS05535	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RN86_RS05555	COG2226	methyltransferase
RN86_RS05570	COG1119	ATPase activity
RN86_RS05575	COG0628	permease
RN86_RS05670	COG0551	DNA topoisomerase type I activity
RN86_RS05670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RN86_RS05675	COG0542	response to heat
RN86_RS05775	COG1253	flavin adenine dinucleotide binding
RN86_RS05785	COG2188	Transcriptional regulator
RN86_RS05790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RN86_RS05790	COG1263	PTS System
RN86_RS05795	COG0366	Alpha amylase catalytic
RN86_RS05810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RN86_RS05815	COG1227	inorganic diphosphatase activity
RN86_RS05830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RN86_RS05835	COG2244	polysaccharide biosynthetic process
RN86_RS05840	COG0626	cystathionine gamma-synthase activity
RN86_RS05845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RN86_RS05850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RN86_RS05855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RN86_RS05860	COG0740	serine-type endopeptidase activity
RN86_RS05865	COG4471	UPF0298 protein
RN86_RS05895	COG0517	IMP dehydrogenase activity
RN86_RS05905	COG2348	transferase activity, transferring amino-acyl groups
RN86_RS05915	COG1078	dGTPase activity
RN86_RS05935	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RN86_RS05955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RN86_RS05960	COG0372	Belongs to the citrate synthase family
RN86_RS05965	COG0538	isocitrate dehydrogenase activity
RN86_RS05975	COG0513	Belongs to the DEAD box helicase family
RN86_RS05985	COG2827	Endonuclease containing a URI domain
RN86_RS05990	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RN86_RS05995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RN86_RS06000	COG0204	Acyl-transferase
RN86_RS06010	COG1555	photosystem II stabilization
RN86_RS06010	COG1596	polysaccharide export
RN86_RS06015	COG2333	competence protein COMEC
RN86_RS06015	COG0658	competence protein
RN86_RS06020	COG1466	dna polymerase III delta subunit
RN86_RS06025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RN86_RS06035	COG4377	Putative membrane peptidase family (DUF2324)
RN86_RS06040	COG0640	Transcriptional regulator
RN86_RS06055	COG2235	arginine
RN86_RS06060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RN86_RS06065	COG0549	Belongs to the carbamate kinase family
RN86_RS06070	COG1288	antiporter activity
RN86_RS06075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RN86_RS06080	COG1438	arginine binding
RN86_RS06085	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RN86_RS06090	COG0363	glucosamine-6-phosphate deaminase activity
RN86_RS06110	COG2723	6-phospho-beta-galactosidase activity
RN86_RS06115	COG4095	Psort location CytoplasmicMembrane, score
RN86_RS06125	COG3711	transcriptional antiterminator
RN86_RS06125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN86_RS06130	COG1447	Phosphotransferase system cellobiose-specific component IIA
RN86_RS06140	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RN86_RS06155	COG4122	O-methyltransferase activity
RN86_RS06160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RN86_RS06170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RN86_RS06175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RN86_RS06180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RN86_RS06185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RN86_RS06190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RN86_RS06200	COG1476	TRANSCRIPTIONal
RN86_RS06225	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RN86_RS06235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RN86_RS06250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RN86_RS06255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RN86_RS06260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RN86_RS06265	COG0297	glycogen (starch) synthase activity
RN86_RS06270	COG0058	SHG alpha-glucan phosphorylase activity
RN86_RS06285	COG0356	it plays a direct role in the translocation of protons across the membrane
RN86_RS06290	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RN86_RS06295	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN86_RS06300	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RN86_RS06305	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RN86_RS06310	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RN86_RS06315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RN86_RS06320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RN86_RS06325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RN86_RS06330	COG0470	DNA polymerase III
RN86_RS06335	COG4467	Involved in initiation control of chromosome replication
RN86_RS06345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RN86_RS06350	COG1393	Belongs to the ArsC family
RN86_RS06365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RN86_RS06380	COG0708	Exodeoxyribonuclease III
RN86_RS06390	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN86_RS06390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN86_RS06405	COG1349	DNA-binding transcription factor activity
RN86_RS06410	COG0698	ribose 5-phosphate isomerase
RN86_RS06415	COG0698	ribose 5-phosphate isomerase
RN86_RS06425	COG3684	Belongs to the aldolase LacD family
RN86_RS06440	COG3775	system Galactitol-specific IIC component
RN86_RS06450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RN86_RS06465	COG0745	RESPONSE REGULATOR receiver
RN86_RS06490	COG1136	(ABC) transporter
RN86_RS06495	COG0577	efflux transmembrane transporter activity
RN86_RS06510	COG3279	Response regulator of the LytR AlgR family
RN86_RS06525	COG1309	transcriptional regulator
RN86_RS06540	COG2226	methyltransferase
RN86_RS06550	COG3250	beta-galactosidase activity
RN86_RS06555	COG1136	(ABC) transporter
RN86_RS06560	COG0577	efflux transmembrane transporter activity
RN86_RS06565	COG0531	amino acid
RN86_RS06570	COG0456	acetyltransferase
RN86_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
RN86_RS06620	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RN86_RS06635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RN86_RS06640	COG0488	(ABC) transporter
RN86_RS06655	COG0494	nUDIX hydrolase
RN86_RS06665	COG1674	ftsk spoiiie
RN86_RS06665	COG0697	spore germination
RN86_RS06670	COG0346	lactoylglutathione lyase activity
RN86_RS06675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RN86_RS06685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RN86_RS06690	COG0081	regulation of translation
RN86_RS06695	COG0531	amino acid
RN86_RS06700	COG1442	glycosyl transferase family 8
RN86_RS06705	COG0528	UMP kinase activity
RN86_RS06710	COG0233	cytoplasmic translational termination
RN86_RS06715	COG2996	Protein conserved in bacteria
RN86_RS06720	COG0768	penicillin binding
RN86_RS06725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RN86_RS06730	COG1181	Belongs to the D-alanine--D-alanine ligase family
RN86_RS06735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RN86_RS06740	COG1051	belongs to the nudix hydrolase family
RN86_RS06760	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RN86_RS06765	COG2884	Cell division ATP-binding protein ftsE
RN86_RS06770	COG2177	Part of the ABC transporter FtsEX involved in
RN86_RS06780	COG1199	ATP-dependent helicase activity
RN86_RS06780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RN86_RS06790	COG0772	Belongs to the SEDS family
RN86_RS06795	COG0693	protein deglycase activity
RN86_RS06805	COG0187	DNA topoisomerase II activity
RN86_RS06810	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
RN86_RS06820	COG0560	Phosphoserine phosphatase
RN86_RS06840	COG0148	phosphopyruvate hydratase activity
RN86_RS06875	COG2706	6-phosphogluconolactonase activity
RN86_RS06890	COG1136	(ABC) transporter
RN86_RS06895	COG0577	efflux transmembrane transporter activity
RN86_RS06900	COG0745	RESPONSE REGULATOR receiver
RN86_RS06905	COG3850	Histidine kinase
RN86_RS06905	COG5002	protein histidine kinase activity
RN86_RS06910	COG2936	dipeptidyl-peptidase activity
RN86_RS06915	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
RN86_RS06920	COG1074	ATP-dependent DNA helicase activity
RN86_RS06930	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RN86_RS06935	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RN86_RS06940	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RN86_RS06945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RN86_RS06950	COG0131	Imidazoleglycerol-phosphate dehydratase
RN86_RS06955	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RN86_RS06960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RN86_RS06965	COG0107	imidazoleglycerol-phosphate synthase activity
RN86_RS06970	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RN86_RS06975	COG0140	phosphoribosyl-ATP diphosphatase activity
RN86_RS06985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RN86_RS06990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RN86_RS06995	COG4109	DRTGG domain
RN86_RS07000	COG0024	Methionine aminopeptidase
RN86_RS07010	COG1846	Transcriptional regulator
RN86_RS07025	COG2246	polysaccharide biosynthetic process
RN86_RS07030	COG4708	membrane
RN86_RS07035	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RN86_RS07040	COG1597	lipid kinase activity
RN86_RS07045	COG1523	belongs to the glycosyl hydrolase 13 family
RN86_RS07060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RN86_RS07065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RN86_RS07070	COG0335	large ribosomal subunit rRNA binding
RN86_RS07085	COG1368	sulfuric ester hydrolase activity
RN86_RS07090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RN86_RS07095	COG0710	3-dehydroquinate dehydratase activity
RN86_RS07100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RN86_RS07105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RN86_RS07110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RN86_RS07115	COG0287	Prephenate dehydrogenase
RN86_RS07120	COG3679	Belongs to the UPF0342 family
RN86_RS07130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RN86_RS07135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RN86_RS07140	COG0077	Prephenate dehydratase
RN86_RS07150	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RN86_RS07170	COG1132	(ABC) transporter
RN86_RS07215	COG0366	Alpha amylase catalytic
RN86_RS07250	COG1131	(ABC) transporter
RN86_RS07260	COG0205	6-phosphofructokinase activity
RN86_RS07265	COG0469	pyruvate kinase activity
RN86_RS07275	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RN86_RS07290	COG2873	o-acetylhomoserine
RN86_RS07305	COG1132	(ABC) transporter
RN86_RS07305	COG2375	cellular response to nickel ion
RN86_RS07310	COG1132	(ABC) transporter
RN86_RS07315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RN86_RS07325	COG0647	UMP catabolic process
RN86_RS07345	COG0228	four-way junction DNA binding
RN86_RS07360	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RN86_RS07365	COG0569	domain protein
RN86_RS07380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RN86_RS07385	COG0336	Belongs to the RNA methyltransferase TrmD family
RN86_RS07390	COG0803	Belongs to the bacterial solute-binding protein 9 family
RN86_RS07390	COG3443	Belongs to the bacterial solute-binding protein 9 family
RN86_RS07400	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN86_RS07415	COG1272	protein, Hemolysin III
RN86_RS07425	COG3022	response to hydroperoxide
RN86_RS07440	COG1175	transmembrane transport
RN86_RS07445	COG0395	ABC-type sugar transport system, permease component
RN86_RS07450	COG1621	beta-fructofuranosidase activity
RN86_RS07455	COG0431	NADPH-dependent FMN reductase
RN86_RS07460	COG1846	Transcriptional regulator
RN86_RS07470	COG0436	Aminotransferase
RN86_RS07490	COG0017	Asparaginyl-tRNA synthetase
RN86_RS07505	COG1132	(ABC) transporter
RN86_RS07515	COG0477	Major facilitator Superfamily
RN86_RS07530	COG0488	(ABC) transporter
RN86_RS07535	COG0492	ferredoxin-NADP+ reductase activity
RN86_RS07540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RN86_RS07545	COG3759	membrane
RN86_RS07570	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RN86_RS07575	COG1970	mechanosensitive ion channel activity
RN86_RS07580	COG0358	DNA primase activity
RN86_RS07585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RN86_RS07590	COG2151	metal-sulfur cluster biosynthetic enzyme
RN86_RS07605	COG1346	cytolysis
RN86_RS07615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RN86_RS07620	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RN86_RS07625	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RN86_RS07630	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RN86_RS07635	COG0038	chloride channel
RN86_RS07645	COG0813	purine-nucleoside phosphorylase activity
RN86_RS07680	COG0543	2 iron, 2 sulfur cluster binding
RN86_RS07685	COG0167	dihydroorotate dehydrogenase activity
RN86_RS07690	COG0284	orotidine-5'-phosphate decarboxylase activity
RN86_RS07695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RN86_RS07710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RN86_RS07715	COG1051	belongs to the nudix hydrolase family
RN86_RS07725	COG0737	Belongs to the 5'-nucleotidase family
RN86_RS07730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RN86_RS07735	COG0187	DNA topoisomerase II activity
RN86_RS07750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RN86_RS07755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RN86_RS07775	COG0539	negative regulation of cytoplasmic translation
RN86_RS07790	COG0039	L-malate dehydrogenase activity
RN86_RS07795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RN86_RS07800	COG3764	Sortase (surface protein transpeptidase)
RN86_RS07805	COG2003	Belongs to the UPF0758 family
RN86_RS07825	COG1104	cysteine desulfurase activity
RN86_RS07830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RN86_RS07840	COG2357	RelA SpoT domain protein
RN86_RS07845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RN86_RS07850	COG0564	pseudouridine synthase activity
RN86_RS07855	COG0280	phosphate acetyltransferase
RN86_RS07860	COG1194	a g-specific adenine glycosylase
RN86_RS07870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN86_RS07875	COG4684	Psort location CytoplasmicMembrane, score
RN86_RS07880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RN86_RS07895	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RN86_RS07900	COG1247	-acetyltransferase
RN86_RS07920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RN86_RS07925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RN86_RS07935	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RN86_RS07940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RN86_RS07945	COG3711	transcriptional antiterminator
RN86_RS07950	COG0110	maltose O-acetyltransferase activity
RN86_RS07955	COG0758	DNA mediated transformation
RN86_RS07960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RN86_RS07975	COG0135	phosphoribosylanthranilate isomerase activity
RN86_RS07980	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RN86_RS07985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RN86_RS07990	COG0222	ribosome binding
RN86_RS08005	COG1132	(ABC) transporter
RN86_RS08015	COG1114	Component of the transport system for branched-chain amino acids
RN86_RS08045	COG5002	protein histidine kinase activity
RN86_RS08050	COG0785	Cytochrome C biogenesis protein
RN86_RS08065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RN86_RS08065	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RN86_RS08070	COG2207	Transcriptional regulator
RN86_RS08070	COG4753	response regulator
RN86_RS08075	COG2972	Histidine kinase
RN86_RS08080	COG0785	Cytochrome C biogenesis protein
RN86_RS08085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN86_RS08090	COG1053	succinate dehydrogenase
RN86_RS08090	COG0431	NADPH-dependent FMN reductase
RN86_RS08090	COG3976	FMN-binding domain protein
RN86_RS08110	COG0038	chloride channel
RN86_RS08115	COG2822	iron ion transport
RN86_RS08120	COG2837	iron assimilation
RN86_RS08125	COG0672	)-iron permease
RN86_RS08130	COG0805	protein transport
RN86_RS08140	COG0534	Mate efflux family protein
RN86_RS08145	COG0516	GMP reductase activity
RN86_RS08150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN86_RS08160	COG0542	response to heat
RN86_RS08165	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RN86_RS08170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RN86_RS08175	COG0022	dehydrogenase e1 component
RN86_RS08180	COG0508	dehydrogenase complex catalyzes the overall conversion of
RN86_RS08185	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
RN86_RS08185	COG3933	PFAM sigma-54 factor interaction domain-containing protein
RN86_RS08190	COG0534	Mate efflux family protein
RN86_RS08205	COG1447	Phosphotransferase system cellobiose-specific component IIA
RN86_RS08210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RN86_RS08215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RN86_RS08220	COG2723	6-phospho-beta-galactosidase activity
RN86_RS08225	COG1942	4-Oxalocrotonate Tautomerase
RN86_RS08230	COG1435	thymidine kinase activity
RN86_RS08235	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RN86_RS08240	COG2890	protein-(glutamine-N5) methyltransferase activity
RN86_RS08245	COG0009	L-threonylcarbamoyladenylate synthase
RN86_RS08250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RN86_RS08260	COG0741	lytic transglycosylase activity
RN86_RS08280	COG1940	carbohydrate kinase activity
RN86_RS08285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RN86_RS08295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RN86_RS08300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RN86_RS08305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RN86_RS08310	COG1388	LysM domain
RN86_RS08310	COG1705	Flagellar rod assembly protein muramidase FlgJ
RN86_RS08320	COG2382	esterase
RN86_RS08330	COG1181	Belongs to the D-alanine--D-alanine ligase family
RN86_RS08335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RN86_RS08340	COG0022	dehydrogenase e1 component
RN86_RS08345	COG0508	dehydrogenase complex catalyzes the overall conversion of
RN86_RS08350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RN86_RS08355	COG0095	Lipoate-protein ligase
RN86_RS08370	COG1674	ftsk spoiiie
RN86_RS08375	COG2946	Replication initiation factor
RN86_RS08405	COG0741	lytic transglycosylase activity
RN86_RS08405	COG0791	NLP P60 protein
RN86_RS08470	COG1028	Short-chain dehydrogenase reductase Sdr
RN86_RS08475	COG4974	Belongs to the 'phage' integrase family
RN86_RS08490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RN86_RS08500	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
RN86_RS08505	COG2188	Transcriptional regulator
RN86_RS08515	COG0488	(ABC) transporter
RN86_RS08520	COG0617	tRNA 3'-terminal CCA addition
RN86_RS08525	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RN86_RS08530	COG1307	EDD domain protein, DegV family
RN86_RS08540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN86_RS08540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN86_RS08540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN86_RS08545	COG1105	Belongs to the carbohydrate kinase PfkB family
RN86_RS08550	COG1349	DNA-binding transcription factor activity
RN86_RS08560	COG0540	Belongs to the ATCase OTCase family
RN86_RS08570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RN86_RS08580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RN86_RS08585	COG0505	Belongs to the CarA family
RN86_RS08590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RN86_RS08600	COG2824	Alkylphosphonate utilization operon protein PhnA
RN86_RS08605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RN86_RS08610	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RN86_RS08615	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RN86_RS08630	COG0564	pseudouridine synthase activity
RN86_RS08640	COG0583	DNA-binding transcription factor activity
RN86_RS08655	COG1079	Belongs to the binding-protein-dependent transport system permease family
RN86_RS08660	COG4603	Belongs to the binding-protein-dependent transport system permease family
RN86_RS08665	COG3845	ABC transporter
RN86_RS08670	COG1744	ABC transporter substrate-binding protein PnrA-like
RN86_RS08675	COG0295	cytidine deaminase activity
RN86_RS08680	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RN86_RS08685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RN86_RS08690	COG2813	Specifically methylates the guanine in position
RN86_RS08695	COG1072	(Pantothenic acid kinase))
RN86_RS08700	COG0268	Binds directly to 16S ribosomal RNA
RN86_RS08715	COG5002	protein histidine kinase activity
RN86_RS08720	COG0745	RESPONSE REGULATOR receiver
RN86_RS08730	COG1268	BioY protein
RN86_RS08790	COG0704	Plays a role in the regulation of phosphate uptake
RN86_RS08795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RN86_RS08800	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RN86_RS08805	COG0581	inorganic phosphate transmembrane transporter activity
RN86_RS08810	COG0573	inorganic phosphate transmembrane transporter activity
RN86_RS08815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RN86_RS08820	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
RN86_RS08820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RN86_RS08825	COG0483	inositol monophosphate 1-phosphatase activity
RN86_RS08830	COG4476	Belongs to the UPF0223 family
RN86_RS08835	COG1393	Belongs to the ArsC family
RN86_RS08840	COG0196	riboflavin kinase activity
RN86_RS08845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RN86_RS08865	COG1827	regulation of RNA biosynthetic process
RN86_RS08900	COG0556	nucleotide-excision repair
RN86_RS08905	COG0765	amino acid transport
RN86_RS08910	COG1126	abc transporter atp-binding protein
RN86_RS08920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RN86_RS08925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RN86_RS08935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RN86_RS08955	COG1368	sulfuric ester hydrolase activity
RN86_RS08960	COG3754	Rhamnan synthesis protein F
RN86_RS08990	COG1091	dTDP-4-dehydrorhamnose reductase activity
RN86_RS08995	COG0463	Glycosyl transferase, family 2
RN86_RS09025	COG0463	Glycosyl transferase, family 2
RN86_RS09030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RN86_RS09035	COG1088	dTDP-glucose 4,6-dehydratase activity
RN86_RS09045	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RN86_RS09060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RN86_RS09065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RN86_RS09070	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RN86_RS09075	COG2384	SAM-dependent methyltransferase
RN86_RS09090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RN86_RS09095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN86_RS09100	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RN86_RS09100	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RN86_RS09120	COG0300	oxidoreductase activity
RN86_RS09125	COG1234	tRNA 3'-trailer cleavage
RN86_RS09135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RN86_RS09140	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RN86_RS09145	COG2814	Major facilitator Superfamily
RN86_RS09155	COG2378	regulation of single-species biofilm formation
RN86_RS09160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RN86_RS09175	COG0765	amino acid transport
RN86_RS09180	COG1126	abc transporter atp-binding protein
RN86_RS09185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RN86_RS09190	COG2131	deaminase
RN86_RS09275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RN86_RS09280	COG1132	(ABC) transporter
RN86_RS09285	COG1132	(ABC) transporter
RN86_RS09290	COG2315	Protein conserved in bacteria
RN86_RS09295	COG3142	Participates in the control of copper homeostasis
RN86_RS09310	COG1481	regulation of sporulation
RN86_RS09315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RN86_RS09320	COG1660	Displays ATPase and GTPase activities
RN86_RS09325	COG0251	oxidation-reduction process
RN86_RS09335	COG0572	uridine kinase
RN86_RS09340	COG0673	inositol 2-dehydrogenase activity
RN86_RS09350	COG0726	polysaccharide deacetylase
RN86_RS09355	COG0596	Alpha beta hydrolase
RN86_RS09360	COG1363	Peptidase, m42
RN86_RS09380	COG3583	domain protein
RN86_RS09380	COG3583	domain protein
RN86_RS09390	COG0574	Belongs to the PEP-utilizing enzyme family
RN86_RS09390	COG3848	Pyruvate phosphate dikinase
RN86_RS09400	COG0688	phosphatidylethanolamine metabolic process
RN86_RS09405	COG1183	phosphatidylcholine synthase activity
RN86_RS09420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RN86_RS09430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RN86_RS09455	COG1122	ATPase activity
RN86_RS09465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RN86_RS09475	COG1174	glycine betaine transport
RN86_RS09490	COG1846	Transcriptional regulator
RN86_RS09500	COG0066	3-isopropylmalate dehydratase activity
RN86_RS09505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RN86_RS09530	COG1609	Transcriptional regulator
RN86_RS09545	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RN86_RS09550	COG1956	GAF domain-containing protein
RN86_RS09565	COG3620	sequence-specific DNA binding
RN86_RS09590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RN86_RS09595	COG4932	domain protein
RN86_RS09600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN86_RS09610	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
RN86_RS09615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RN86_RS09620	COG3442	glutamine amidotransferase
RN86_RS09645	COG0488	(ABC) transporter
RN86_RS09650	COG1136	(ABC) transporter
RN86_RS09655	COG0577	efflux transmembrane transporter activity
RN86_RS09685	COG0072	phenylalanine-tRNA ligase activity
RN86_RS09685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN86_RS09700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RN86_RS09715	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RN86_RS09725	COG3527	Alpha-acetolactate decarboxylase
RN86_RS09735	COG0628	permease
RN86_RS09740	COG0716	FMN binding
RN86_RS09745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RN86_RS09750	COG0254	rRNA binding
RN86_RS09780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RN86_RS09785	COG3321	synthase
RN86_RS09785	COG0604	alcohol dehydrogenase
RN86_RS09805	COG1573	uracil-dna glycosylase
RN86_RS09835	COG0322	excinuclease ABC activity
RN86_RS09840	COG1011	Hydrolase
RN86_RS09850	COG2207	Transcriptional regulator
RN86_RS09850	COG3708	Transcriptional regulator
RN86_RS09860	COG3201	nicotinamide mononucleotide transporter
RN86_RS09870	COG0481	GTPase activity
RN86_RS09875	COG0561	phosphatase activity
RN86_RS09885	COG0425	Belongs to the sulfur carrier protein TusA family
RN86_RS09885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RN86_RS09915	COG1388	LysM domain
RN86_RS09915	COG0860	N-Acetylmuramoyl-L-alanine amidase
RN86_RS10025	COG0582	viral genome integration into host DNA
RN86_RS10125	COG1396	sequence-specific DNA binding
RN86_RS10140	COG0582	viral genome integration into host DNA
RN86_RS10145	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RN86_RS10155	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RN86_RS10170	COG0301	tRNA thio-modification
RN86_RS10175	COG1104	cysteine desulfurase activity
RN86_RS10180	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
RN86_RS10185	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RN86_RS10190	COG0517	IMP dehydrogenase activity
RN86_RS10195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN86_RS10195	COG0574	Belongs to the PEP-utilizing enzyme family
RN86_RS10210	COG1177	transmembrane transport
RN86_RS10215	COG1176	ABC-type spermidine putrescine transport system, permease component I
RN86_RS10220	COG3842	ATPase activity
RN86_RS10225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RN86_RS10235	COG0083	homoserine kinase activity
RN86_RS10255	COG1131	(ABC) transporter
RN86_RS10260	COG4187	Peptidase family M20/M25/M40
RN86_RS10280	COG3091	SprT-like family
RN86_RS10285	COG2183	response to ionizing radiation
RN86_RS10290	COG0701	Predicted permease
RN86_RS10295	COG3689	TIGRFAM TIGR03943 family protein
RN86_RS10300	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RN86_RS10305	COG0552	protein localization to endoplasmic reticulum
RN86_RS10310	COG0561	phosphatase activity
RN86_RS10315	COG0561	phosphatase activity
RN86_RS10320	COG1196	nuclear chromosome segregation
RN86_RS10325	COG0571	ribonuclease III activity
RN86_RS10330	COG2832	Protein of unknown function (DUF454)
RN86_RS10335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RN86_RS10345	COG0745	RESPONSE REGULATOR receiver
RN86_RS10350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RN86_RS10365	COG0438	transferase activity, transferring glycosyl groups
RN86_RS10375	COG1609	Transcriptional regulator
RN86_RS10380	COG0006	proline dipeptidase activity
RN86_RS10385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN86_RS10390	COG1120	ATPase activity
RN86_RS10415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RN86_RS10425	COG0149	triose-phosphate isomerase activity
RN86_RS10430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RN86_RS10435	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RN86_RS10440	COG0772	Belongs to the SEDS family
RN86_RS10445	COG0386	Belongs to the glutathione peroxidase family
RN86_RS10460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RN86_RS10470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RN86_RS10475	COG0577	efflux transmembrane transporter activity
RN86_RS10480	COG1136	(ABC) transporter
RN86_RS10490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RN86_RS10495	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RN86_RS10500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RN86_RS10505	COG1268	BioY protein
RN86_RS10510	COG4443	Transcriptional Coactivator p15 (PC4)
RN86_RS10520	COG0826	peptidase U32
RN86_RS10550	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RN86_RS10555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RN86_RS10560	COG1051	belongs to the nudix hydrolase family
RN86_RS10565	COG1983	PspC domain protein
RN86_RS10570	COG2514	catechol 2,3-dioxygenase activity
RN86_RS10575	COG1959	2 iron, 2 sulfur cluster binding
RN86_RS10595	COG1309	transcriptional regulator
RN86_RS10620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RN86_RS10625	COG0557	exoribonuclease II activity
RN86_RS10635	COG2814	Major facilitator Superfamily
RN86_RS10640	COG0237	dephospho-CoA kinase activity
RN86_RS10645	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RN86_RS10655	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RN86_RS10660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RN86_RS10665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RN86_RS10675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RN86_RS10680	COG0686	Belongs to the AlaDH PNT family
RN86_RS10690	COG1702	phosphate starvation-inducible protein PhoH
RN86_RS10695	COG4479	Belongs to the UPF0346 family
RN86_RS10700	COG0588	phosphoglycerate mutase activity
RN86_RS10705	COG0735	belongs to the Fur family
RN86_RS10715	COG1307	EDD domain protein, DegV family
RN86_RS10720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RN86_RS10725	COG0497	DNA recombination
RN86_RS10730	COG1438	arginine binding
RN86_RS10735	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
RN86_RS10745	COG1722	exodeoxyribonuclease VII activity
RN86_RS10750	COG1570	exodeoxyribonuclease VII activity
RN86_RS10755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RN86_RS10765	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RN86_RS10770	COG4703	Protein of unknown function (DUF1797)
RN86_RS10775	COG0542	response to heat
RN86_RS10785	COG2378	regulation of single-species biofilm formation
RN86_RS10790	COG0406	alpha-ribazole phosphatase activity
RN86_RS10790	COG0494	nUDIX hydrolase
RN86_RS10810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RN86_RS10815	COG3599	regulation of cell shape
RN86_RS10820	COG2302	S4 RNA-binding domain
RN86_RS10830	COG1799	cell septum assembly
RN86_RS10835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RN86_RS10850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RN86_RS10855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RN86_RS10860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RN86_RS10870	COG1217	gtp-binding protein TYPA
RN86_RS10875	COG1187	pseudouridine synthase activity
RN86_RS10880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RN86_RS10895	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RN86_RS10900	COG0159	tryptophan synthase activity
RN86_RS10910	COG0135	phosphoribosylanthranilate isomerase activity
RN86_RS10915	COG0134	indole-3-glycerol-phosphate synthase activity
RN86_RS10920	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RN86_RS10925	COG0512	Glutamine amidotransferase of anthranilate synthase
RN86_RS10930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RN86_RS10935	COG0133	tryptophan synthase activity
RN86_RS10945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RN86_RS10950	COG4470	Protein conserved in bacteria
RN86_RS10955	COG3480	Lon protease (S16) C-terminal proteolytic domain
RN86_RS10960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RN86_RS10965	COG0742	ribosomal rna small subunit methyltransferase
RN86_RS10975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RN86_RS10980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RN86_RS11015	COG0525	valine-tRNA ligase activity
RN86_RS11025	COG0519	Catalyzes the synthesis of GMP from XMP
RN86_RS11050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RN86_RS11055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RN86_RS11060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RN86_RS11065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RN86_RS11075	COG2137	regulation of response to DNA damage stimulus
RN86_RS11080	COG3557	Belongs to the UPF0374 family