locus-tag	class	description
I6H76_RS00005	COG1132	(ABC) transporter
I6H76_RS00010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6H76_RS00025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6H76_RS00030	COG1247	-acetyltransferase
I6H76_RS00035	COG0242	peptide deformylase activity
I6H76_RS00050	COG1132	(ABC) transporter
I6H76_RS00055	COG2357	RelA SpoT domain protein
I6H76_RS00060	COG0745	RESPONSE REGULATOR receiver
I6H76_RS00065	COG5002	protein histidine kinase activity
I6H76_RS00070	COG0656	L-ascorbic acid biosynthetic process
I6H76_RS00075	COG0583	DNA-binding transcription factor activity
I6H76_RS00085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H76_RS00090	COG0765	amino acid transport
I6H76_RS00095	COG0765	amino acid transport
I6H76_RS00100	COG1126	abc transporter atp-binding protein
I6H76_RS00105	COG0765	amino acid transport
I6H76_RS00110	COG4215	(ABC) transporter
I6H76_RS00115	COG1126	abc transporter atp-binding protein
I6H76_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H76_RS00145	COG1272	protein, Hemolysin III
I6H76_RS00160	COG3425	synthase
I6H76_RS00165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6H76_RS00170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6H76_RS00185	COG0833	amino acid
I6H76_RS00190	COG2040	homocysteine
I6H76_RS00220	COG1309	transcriptional regulator
I6H76_RS00235	COG0726	polysaccharide deacetylase
I6H76_RS00250	COG2962	Rard protein
I6H76_RS00255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H76_RS00260	COG0285	dihydrofolate synthase activity
I6H76_RS00285	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6H76_RS00295	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6H76_RS00300	COG1177	transmembrane transport
I6H76_RS00325	COG1054	Belongs to the UPF0176 family
I6H76_RS00355	COG0038	chloride channel
I6H76_RS00360	COG3711	transcriptional antiterminator
I6H76_RS00365	COG2190	(PTS) system
I6H76_RS00365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H76_RS00365	COG1263	PTS System
I6H76_RS00370	COG2207	Transcriptional regulator
I6H76_RS00425	COG1028	Short-chain dehydrogenase reductase Sdr
I6H76_RS00430	COG0656	L-ascorbic acid biosynthetic process
I6H76_RS00435	COG0561	phosphatase activity
I6H76_RS00455	COG0561	phosphatase activity
I6H76_RS00460	COG1115	amino acid carrier protein
I6H76_RS00465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H76_RS00510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6H76_RS00520	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6H76_RS00530	COG2873	o-acetylhomoserine
I6H76_RS00550	COG0577	efflux transmembrane transporter activity
I6H76_RS00550	COG1136	(ABC) transporter
I6H76_RS00580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6H76_RS00585	COG0196	riboflavin kinase activity
I6H76_RS00590	COG1393	Belongs to the ArsC family
I6H76_RS00595	COG4476	Belongs to the UPF0223 family
I6H76_RS00600	COG0483	inositol monophosphate 1-phosphatase activity
I6H76_RS00620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H76_RS00625	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6H76_RS00625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H76_RS00635	COG0573	inorganic phosphate transmembrane transporter activity
I6H76_RS00640	COG0581	inorganic phosphate transmembrane transporter activity
I6H76_RS00645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H76_RS00650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H76_RS00655	COG0704	Plays a role in the regulation of phosphate uptake
I6H76_RS00665	COG0745	RESPONSE REGULATOR receiver
I6H76_RS00670	COG5002	protein histidine kinase activity
I6H76_RS00680	COG1072	(Pantothenic acid kinase))
I6H76_RS00685	COG2813	Specifically methylates the guanine in position
I6H76_RS00695	COG1744	ABC transporter substrate-binding protein PnrA-like
I6H76_RS00700	COG3845	ABC transporter
I6H76_RS00705	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6H76_RS00710	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6H76_RS00730	COG3764	Sortase (surface protein transpeptidase)
I6H76_RS00735	COG0346	lactoylglutathione lyase activity
I6H76_RS00755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6H76_RS00760	COG4684	Psort location CytoplasmicMembrane, score
I6H76_RS00765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H76_RS00770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6H76_RS00780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6H76_RS00785	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6H76_RS00790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6H76_RS00795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H76_RS00810	COG0488	(ABC) transporter
I6H76_RS00815	COG1131	(ABC) transporter
I6H76_RS00865	COG1573	uracil-dna glycosylase
I6H76_RS00885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H76_RS00900	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H76_RS00905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H76_RS00910	COG1780	Probably involved in ribonucleotide reductase function
I6H76_RS00915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H76_RS00930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H76_RS00940	COG1960	acyl-CoA dehydrogenase activity
I6H76_RS00955	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H76_RS00960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H76_RS00965	COG0110	maltose O-acetyltransferase activity
I6H76_RS00970	COG0758	DNA mediated transformation
I6H76_RS00975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H76_RS01000	COG1136	(ABC) transporter
I6H76_RS01005	COG0577	efflux transmembrane transporter activity
I6H76_RS01010	COG0745	RESPONSE REGULATOR receiver
I6H76_RS01015	COG5002	protein histidine kinase activity
I6H76_RS01025	COG4974	Belongs to the 'phage' integrase family
I6H76_RS01035	COG2207	Transcriptional regulator
I6H76_RS01045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6H76_RS01055	COG2188	Transcriptional regulator
I6H76_RS01070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6H76_RS01095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6H76_RS01120	COG0534	Mate efflux family protein
I6H76_RS01130	COG0366	Alpha amylase catalytic
I6H76_RS01130	COG5263	repeat protein
I6H76_RS01135	COG1396	sequence-specific DNA binding
I6H76_RS01190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6H76_RS01190	COG0519	Catalyzes the synthesis of GMP from XMP
I6H76_RS01200	COG1418	mRNA catabolic process
I6H76_RS01205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H76_RS01210	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6H76_RS01220	COG1937	Protein conserved in bacteria
I6H76_RS01245	COG0095	Lipoate-protein ligase
I6H76_RS01250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6H76_RS01265	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H76_RS01270	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6H76_RS01270	COG0022	dehydrogenase e1 component
I6H76_RS01275	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6H76_RS01290	COG1132	(ABC) transporter
I6H76_RS01315	COG0009	L-threonylcarbamoyladenylate synthase
I6H76_RS01320	COG2890	protein-(glutamine-N5) methyltransferase activity
I6H76_RS01325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6H76_RS01350	COG2233	PERMEase
I6H76_RS01360	COG0516	GMP reductase activity
I6H76_RS01365	COG0561	phosphatase activity
I6H76_RS01375	COG4221	oxidoreductase activity
I6H76_RS01380	COG0280	phosphate acetyltransferase
I6H76_RS01385	COG0564	pseudouridine synthase activity
I6H76_RS01395	COG2357	RelA SpoT domain protein
I6H76_RS01400	COG4116	CYTH
I6H76_RS01410	COG1104	cysteine desulfurase activity
I6H76_RS01420	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6H76_RS01430	COG0628	permease
I6H76_RS01440	COG2723	6-phospho-beta-galactosidase activity
I6H76_RS01445	COG1115	amino acid carrier protein
I6H76_RS01450	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6H76_RS01460	COG1126	abc transporter atp-binding protein
I6H76_RS01465	COG0765	amino acid transport
I6H76_RS01470	COG2824	Alkylphosphonate utilization operon protein PhnA
I6H76_RS01475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6H76_RS01485	COG0469	pyruvate kinase activity
I6H76_RS01490	COG0205	6-phosphofructokinase activity
I6H76_RS01500	COG1725	Transcriptional regulator
I6H76_RS01505	COG1131	(ABC) transporter
I6H76_RS01525	COG1380	Effector of murein hydrolase LrgA
I6H76_RS01530	COG1346	cytolysis
I6H76_RS01540	COG0539	negative regulation of cytoplasmic translation
I6H76_RS01560	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6H76_RS01565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6H76_RS01570	COG0187	DNA topoisomerase II activity
I6H76_RS01590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6H76_RS01595	COG1881	PFAM PEBP family protein
I6H76_RS01605	COG0284	orotidine-5'-phosphate decarboxylase activity
I6H76_RS01610	COG0167	dihydroorotate dehydrogenase activity
I6H76_RS01625	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6H76_RS01675	COG0438	transferase activity, transferring glycosyl groups
I6H76_RS01690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6H76_RS01710	COG1316	TRANSCRIPTIONal
I6H76_RS01740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6H76_RS01745	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6H76_RS01765	COG1573	uracil-dna glycosylase
I6H76_RS01795	COG0322	excinuclease ABC activity
I6H76_RS01800	COG1012	belongs to the aldehyde dehydrogenase family
I6H76_RS01805	COG2855	membrane
I6H76_RS01810	COG0583	DNA-binding transcription factor activity
I6H76_RS01815	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H76_RS01820	COG1011	Hydrolase
I6H76_RS01825	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6H76_RS01830	COG1136	(ABC) transporter
I6H76_RS01850	COG0789	Transcriptional regulator
I6H76_RS01860	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H76_RS01875	COG0640	Transcriptional regulator
I6H76_RS01885	COG1132	(ABC) transporter
I6H76_RS01890	COG1132	(ABC) transporter
I6H76_RS01900	COG0488	(ABC) transporter
I6H76_RS01915	COG1122	ATPase activity
I6H76_RS01920	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6H76_RS01930	COG4187	Peptidase family M20/M25/M40
I6H76_RS01935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H76_RS01940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6H76_RS01950	COG0765	amino acid transport
I6H76_RS01955	COG1126	abc transporter atp-binding protein
I6H76_RS01960	COG0583	DNA-binding transcription factor activity
I6H76_RS01965	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6H76_RS01970	COG0531	amino acid
I6H76_RS01975	COG3527	Alpha-acetolactate decarboxylase
I6H76_RS01980	COG0028	Belongs to the TPP enzyme family
I6H76_RS01990	COG0457	Tetratricopeptide repeat
I6H76_RS01995	COG0628	permease
I6H76_RS02000	COG1051	belongs to the nudix hydrolase family
I6H76_RS02245	COG0582	viral genome integration into host DNA
I6H76_RS02250	COG1088	dTDP-glucose 4,6-dehydratase activity
I6H76_RS02260	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6H76_RS02270	COG2384	SAM-dependent methyltransferase
I6H76_RS02275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6H76_RS02295	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6H76_RS02300	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6H76_RS02300	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6H76_RS02305	COG0300	oxidoreductase activity
I6H76_RS02320	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6H76_RS02350	COG1074	ATP-dependent DNA helicase activity
I6H76_RS02355	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6H76_RS02365	COG2801	Transposase and inactivated derivatives
I6H76_RS02395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H76_RS02445	COG1597	lipid kinase activity
I6H76_RS02450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6H76_RS02455	COG4708	membrane
I6H76_RS02460	COG2246	polysaccharide biosynthetic process
I6H76_RS02470	COG0024	Methionine aminopeptidase
I6H76_RS02475	COG4109	DRTGG domain
I6H76_RS02480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6H76_RS02485	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6H76_RS02490	COG3708	Transcriptional regulator
I6H76_RS02490	COG2207	Transcriptional regulator
I6H76_RS02495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6H76_RS02500	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6H76_RS02500	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6H76_RS02510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6H76_RS02515	COG1956	GAF domain-containing protein
I6H76_RS02520	COG0066	3-isopropylmalate dehydratase activity
I6H76_RS02525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6H76_RS02550	COG0513	Belongs to the DEAD box helicase family
I6H76_RS02590	COG0372	Belongs to the citrate synthase family
I6H76_RS02595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6H76_RS02600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6H76_RS02605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H76_RS02610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6H76_RS02615	COG3859	Proton-coupled thiamine transporter YuaJ
I6H76_RS02625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H76_RS02625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6H76_RS02630	COG0307	riboflavin synthase, alpha
I6H76_RS02635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H76_RS02635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6H76_RS02645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6H76_RS02650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6H76_RS02655	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6H76_RS02665	COG0436	Aminotransferase
I6H76_RS02670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6H76_RS02685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6H76_RS02690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6H76_RS02695	COG4122	O-methyltransferase activity
I6H76_RS02700	COG0546	phosphoglycolate phosphatase activity
I6H76_RS02720	COG1187	pseudouridine synthase activity
I6H76_RS02725	COG0363	glucosamine-6-phosphate deaminase activity
I6H76_RS02735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6H76_RS02740	COG0217	transcriptional regulatory protein
I6H76_RS02745	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6H76_RS02750	COG1466	dna polymerase III delta subunit
I6H76_RS02770	COG0658	competence protein
I6H76_RS02770	COG2333	competence protein COMEC
I6H76_RS02775	COG1555	photosystem II stabilization
I6H76_RS02775	COG1596	polysaccharide export
I6H76_RS02780	COG0204	Acyl-transferase
I6H76_RS02785	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6H76_RS02795	COG0513	Belongs to the DEAD box helicase family
I6H76_RS02815	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H76_RS02820	COG0385	Bile acid
I6H76_RS02830	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H76_RS02840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6H76_RS02845	COG0768	penicillin binding
I6H76_RS02855	COG1827	regulation of RNA biosynthetic process
I6H76_RS02860	COG0588	phosphoglycerate mutase activity
I6H76_RS02865	COG2217	Heavy metal translocating P-type atpase
I6H76_RS02870	COG0640	Transcriptional regulator
I6H76_RS02875	COG0167	dihydroorotate dehydrogenase activity
I6H76_RS02880	COG3104	oligopeptide transport
I6H76_RS02895	COG4698	Protein conserved in bacteria
I6H76_RS02900	COG2755	lipolytic protein G-D-S-L family
I6H76_RS02905	COG1307	EDD domain protein, DegV family
I6H76_RS02910	COG0497	DNA recombination
I6H76_RS02915	COG1438	arginine binding
I6H76_RS02920	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6H76_RS02950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6H76_RS02965	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6H76_RS02965	COG1918	ferrous iron import across plasma membrane
I6H76_RS02975	COG1126	abc transporter atp-binding protein
I6H76_RS02980	COG0765	amino acid transport
I6H76_RS02985	COG4703	Protein of unknown function (DUF1797)
I6H76_RS02990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6H76_RS03010	COG0542	response to heat
I6H76_RS03030	COG3599	regulation of cell shape
I6H76_RS03045	COG1799	cell septum assembly
I6H76_RS03050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6H76_RS03070	COG2801	Transposase and inactivated derivatives
I6H76_RS03115	COG1217	gtp-binding protein TYPA
I6H76_RS03125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6H76_RS03130	COG1940	carbohydrate kinase activity
I6H76_RS03140	COG0783	Belongs to the Dps family
I6H76_RS03150	COG1914	H( )-stimulated, divalent metal cation uptake system
I6H76_RS03155	COG0159	tryptophan synthase activity
I6H76_RS03160	COG0133	tryptophan synthase activity
I6H76_RS03165	COG0135	phosphoribosylanthranilate isomerase activity
I6H76_RS03180	COG0512	Glutamine amidotransferase of anthranilate synthase
I6H76_RS03185	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6H76_RS03195	COG2197	response regulator
I6H76_RS03200	COG4585	Histidine kinase
I6H76_RS03210	COG1131	(ABC) transporter
I6H76_RS03215	COG1132	(ABC) transporter
I6H76_RS03220	COG1132	(ABC) transporter
I6H76_RS03235	COG4470	Protein conserved in bacteria
I6H76_RS03240	COG0737	Belongs to the 5'-nucleotidase family
I6H76_RS03250	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6H76_RS03255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6H76_RS03260	COG0742	ribosomal rna small subunit methyltransferase
I6H76_RS03280	COG2814	Major facilitator Superfamily
I6H76_RS03295	COG1396	sequence-specific DNA binding
I6H76_RS03300	COG0525	valine-tRNA ligase activity
I6H76_RS03310	COG0519	Catalyzes the synthesis of GMP from XMP
I6H76_RS03330	COG1428	Deoxynucleoside kinase
I6H76_RS03355	COG4175	Glycine betaine
I6H76_RS03355	COG3448	diguanylate cyclase activity
I6H76_RS03380	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H76_RS03390	COG2137	regulation of response to DNA damage stimulus
I6H76_RS03395	COG3557	Belongs to the UPF0374 family
I6H76_RS03465	COG1040	competence protein
I6H76_RS03470	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6H76_RS03475	COG1739	Uncharacterized protein family UPF0029
I6H76_RS03485	COG1098	S1 RNA binding domain
I6H76_RS03495	COG2197	response regulator
I6H76_RS03500	COG4585	Histidine kinase
I6H76_RS03510	COG0515	serine threonine protein kinase
I6H76_RS03510	COG2815	serine threonine protein kinase
I6H76_RS03520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6H76_RS03520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H76_RS03530	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6H76_RS03550	COG1854	S-ribosylhomocysteine lyase activity
I6H76_RS03565	COG0116	Belongs to the methyltransferase superfamily
I6H76_RS03575	COG3599	regulation of cell shape
I6H76_RS03585	COG3331	DNA recombination
I6H76_RS03590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H76_RS03595	COG3579	cysteine-type endopeptidase activity
I6H76_RS03605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6H76_RS03610	COG0492	ferredoxin-NADP+ reductase activity
I6H76_RS03620	COG1126	abc transporter atp-binding protein
I6H76_RS03630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H76_RS03635	COG0513	Belongs to the DEAD box helicase family
I6H76_RS03640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H76_RS03645	COG0768	penicillin binding
I6H76_RS03655	COG0275	rRNA processing
I6H76_RS03665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6H76_RS03675	COG1131	(ABC) transporter
I6H76_RS03735	COG0561	phosphatase activity
I6H76_RS03740	COG2860	membrane
I6H76_RS03750	COG2217	Heavy metal translocating P-type atpase
I6H76_RS03765	COG1611	Belongs to the LOG family
I6H76_RS03770	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6H76_RS03775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6H76_RS03785	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6H76_RS03790	COG0195	Participates in both transcription termination and antitermination
I6H76_RS03815	COG5001	Diguanylate cyclase
I6H76_RS03815	COG3300	MHYT domain
I6H76_RS03825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6H76_RS03835	COG4473	ABC transporter
I6H76_RS03840	COG1131	(ABC) transporter
I6H76_RS03845	COG0537	adenosine 5'-monophosphoramidase activity
I6H76_RS03855	COG1316	TRANSCRIPTIONal
I6H76_RS03865	COG0802	atpase or kinase
I6H76_RS03870	COG2252	PERMEase
I6H76_RS03885	COG0561	phosphatase activity
I6H76_RS03895	COG3715	PTS system
I6H76_RS03900	COG3716	PTS system mannose fructose sorbose family IID component
I6H76_RS03910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6H76_RS03925	COG0439	Biotin carboxylase
I6H76_RS03940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6H76_RS03945	COG1028	Short-chain dehydrogenase reductase Sdr
I6H76_RS03950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6H76_RS03965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6H76_RS03975	COG1024	Enoyl-CoA hydratase
I6H76_RS03980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H76_RS03985	COG0527	aspartate kinase activity
I6H76_RS04020	COG4608	Belongs to the ABC transporter superfamily
I6H76_RS04025	COG0444	Belongs to the ABC transporter superfamily
I6H76_RS04030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6H76_RS04035	COG0601	transmembrane transport
I6H76_RS04040	COG4166	transmembrane transport
I6H76_RS04045	COG1686	Belongs to the peptidase S11 family
I6H76_RS04050	COG0719	Fe-S assembly protein
I6H76_RS04060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6H76_RS04065	COG0719	Fe-S assembly protein
I6H76_RS04075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6H76_RS04095	COG0765	amino acid transport
I6H76_RS04100	COG1126	abc transporter atp-binding protein
I6H76_RS04115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6H76_RS04125	COG0440	acetolactate synthase activity
I6H76_RS04130	COG0028	Belongs to the TPP enzyme family
I6H76_RS04135	COG0129	dihydroxy-acid dehydratase activity
I6H76_RS04140	COG1461	Dihydroxyacetone kinase
I6H76_RS04150	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6H76_RS04160	COG0191	fructose-bisphosphate aldolase activity
I6H76_RS04175	COG0504	CTP synthase activity
I6H76_RS04190	COG0668	transmembrane transport
I6H76_RS04230	COG0443	Heat shock 70 kDa protein
I6H76_RS04235	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6H76_RS04245	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H76_RS04245	COG1388	LysM domain
I6H76_RS04250	COG1876	peptidase activity
I6H76_RS04255	COG0588	phosphoglycerate mutase activity
I6H76_RS04265	COG3830	Belongs to the UPF0237 family
I6H76_RS04325	COG1674	ftsk spoiiie
I6H76_RS04360	COG2217	Heavy metal translocating P-type atpase
I6H76_RS04385	COG2514	catechol 2,3-dioxygenase activity
I6H76_RS04390	COG1959	2 iron, 2 sulfur cluster binding
I6H76_RS04400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H76_RS04405	COG0778	Nitroreductase
I6H76_RS04430	COG3942	CHAP domain
I6H76_RS04430	COG1388	LysM domain
I6H76_RS04450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6H76_RS04455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6H76_RS04480	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H76_RS04485	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6H76_RS04495	COG1045	serine acetyltransferase
I6H76_RS04505	COG1185	polyribonucleotide nucleotidyltransferase activity
I6H76_RS04515	COG1454	alcohol dehydrogenase
I6H76_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
I6H76_RS04565	COG4589	Belongs to the CDS family
I6H76_RS04570	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6H76_RS04575	COG1862	Preprotein translocase
I6H76_RS04585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6H76_RS04590	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6H76_RS04595	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6H76_RS04600	COG1609	Transcriptional regulator
I6H76_RS04610	COG0366	Alpha amylase catalytic
I6H76_RS04615	COG0366	Alpha amylase catalytic
I6H76_RS04620	COG0395	ABC-type sugar transport system, permease component
I6H76_RS04625	COG1175	transmembrane transport
I6H76_RS04630	COG1653	transport
I6H76_RS04635	COG3345	alpha-galactosidase
I6H76_RS04640	COG2207	Transcriptional regulator
I6H76_RS04675	COG3711	transcriptional antiterminator
I6H76_RS04700	COG0698	ribose 5-phosphate isomerase
I6H76_RS04710	COG3842	ATPase activity
I6H76_RS04730	COG1940	carbohydrate kinase activity
I6H76_RS04735	COG2188	Transcriptional regulator
I6H76_RS04755	COG1482	cell wall glycoprotein biosynthetic process
I6H76_RS04760	COG2188	Transcriptional regulator
I6H76_RS04780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6H76_RS04790	COG1363	Peptidase, m42
I6H76_RS04800	COG2190	(PTS) system
I6H76_RS04800	COG1263	PTS System
I6H76_RS04800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H76_RS04810	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6H76_RS04835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6H76_RS04880	COG0436	Aminotransferase
I6H76_RS04890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6H76_RS04900	COG2017	converts alpha-aldose to the beta-anomer
I6H76_RS04910	COG4667	esterase of the alpha-beta hydrolase superfamily
I6H76_RS04915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6H76_RS04940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6H76_RS04950	COG0564	pseudouridine synthase activity
I6H76_RS04960	COG1396	sequence-specific DNA binding
I6H76_RS04975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6H76_RS04980	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6H76_RS05015	COG0425	Belongs to the sulfur carrier protein TusA family
I6H76_RS05020	COG2391	methyltransferase activity
I6H76_RS05035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6H76_RS05040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6H76_RS05050	COG1363	Peptidase, m42
I6H76_RS05055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6H76_RS05110	COG4537	Required for transformation and DNA binding
I6H76_RS05115	COG1459	type II secretion system
I6H76_RS05120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6H76_RS05130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6H76_RS05150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6H76_RS05155	COG1121	(ABC) transporter
I6H76_RS05165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6H76_RS05275	COG0203	ribosomal protein L17
I6H76_RS05280	COG0202	RNA polymerase activity
I6H76_RS05285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6H76_RS05310	COG0201	protein transport
I6H76_RS05320	COG1841	ribosomal large subunit assembly
I6H76_RS05325	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6H76_RS05345	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6H76_RS05355	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6H76_RS05370	COG0255	Belongs to the universal ribosomal protein uL29 family
I6H76_RS05405	COG0088	Forms part of the polypeptide exit tunnel
I6H76_RS05415	COG0051	transcription antitermination factor activity, RNA binding
I6H76_RS05420	COG0534	Mate efflux family protein
I6H76_RS05430	COG2755	lipolytic protein G-D-S-L family
I6H76_RS05430	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6H76_RS05450	COG2255	four-way junction helicase activity
I6H76_RS05460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6H76_RS05470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6H76_RS05490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6H76_RS05495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6H76_RS05510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6H76_RS05515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6H76_RS05520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H76_RS05525	COG0416	fatty acid biosynthetic process
I6H76_RS05535	COG0436	Aminotransferase
I6H76_RS05545	COG3942	CHAP domain
I6H76_RS05555	COG1792	Involved in formation and maintenance of cell shape
I6H76_RS05730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6H76_RS05760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6H76_RS05770	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6H76_RS05780	COG0012	GTP binding
I6H76_RS05795	COG0592	DNA-directed DNA polymerase activity
I6H76_RS05805	COG1475	DNA binding
I6H76_RS05810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6H76_RS05845	COG0488	(ABC) transporter
I6H76_RS05860	COG0516	GMP reductase activity
I6H76_RS05860	COG0517	IMP dehydrogenase activity
I6H76_RS05870	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6H76_RS05880	COG0612	Peptidase, M16
I6H76_RS05885	COG0612	Peptidase, M16
I6H76_RS05905	COG1122	ATPase activity
I6H76_RS05920	COG0741	lytic transglycosylase activity
I6H76_RS05925	COG0546	phosphoglycolate phosphatase activity
I6H76_RS05930	COG1760	l-serine dehydratase
I6H76_RS05935	COG1760	l-serine dehydratase
I6H76_RS05950	COG0445	tRNA wobble uridine modification
I6H76_RS05965	COG0305	Participates in initiation and elongation during chromosome replication
I6H76_RS05970	COG4466	Protein conserved in bacteria
I6H76_RS05980	COG1309	transcriptional regulator
I6H76_RS05985	COG1511	domain protein
I6H76_RS05990	COG3759	membrane
I6H76_RS06000	COG3237	CsbD-like
I6H76_RS06020	COG2261	transglycosylase associated protein
I6H76_RS06035	COG1597	lipid kinase activity
I6H76_RS06070	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6H76_RS06090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H76_RS06095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6H76_RS06140	COG0519	Catalyzes the synthesis of GMP from XMP
I6H76_RS06150	COG1058	Belongs to the CinA family
I6H76_RS06150	COG1546	Belongs to the CinA family
I6H76_RS06160	COG1393	Belongs to the ArsC family
I6H76_RS06165	COG4472	Bacterial protein of unknown function (DUF965)
I6H76_RS06185	COG1328	CTP reductase activity
I6H76_RS06185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6H76_RS06200	COG0602	queuosine metabolic process
I6H76_RS06215	COG0681	Belongs to the peptidase S26 family
I6H76_RS06230	COG3590	peptidase
I6H76_RS06235	COG1396	sequence-specific DNA binding
I6H76_RS06270	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6H76_RS06285	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6H76_RS06295	COG4463	regulation of RNA biosynthetic process
I6H76_RS06300	COG0542	response to heat
I6H76_RS06305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6H76_RS06310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6H76_RS06325	COG2918	glutathione biosynthetic process
I6H76_RS06325	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6H76_RS06330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6H76_RS06345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H76_RS06345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6H76_RS06350	COG1832	CoA-binding protein
I6H76_RS06365	COG0343	queuine tRNA-ribosyltransferase activity
I6H76_RS06375	COG1268	BioY protein
I6H76_RS06380	COG1234	tRNA 3'-trailer cleavage
I6H76_RS06395	COG0166	Belongs to the GPI family
I6H76_RS06405	COG2171	N-acyltransferase activity
I6H76_RS06410	COG1473	amidohydrolase
I6H76_RS06415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6H76_RS06425	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6H76_RS06440	COG0756	dUTP diphosphatase activity
I6H76_RS06455	COG4989	oxidoreductase activity
I6H76_RS06465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6H76_RS06470	COG2807	transmembrane transport
I6H76_RS06485	COG0594	ribonuclease P activity
I6H76_RS06595	COG0629	single-stranded DNA binding
I6H76_RS06625	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6H76_RS06625	COG0551	DNA topoisomerase type I activity
I6H76_RS06645	COG3843	relaxase mobilization nuclease domain protein
I6H76_RS06655	COG1598	PFAM Uncharacterised protein family UPF0150
I6H76_RS06660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6H76_RS06725	COG3344	reverse transcriptase
I6H76_RS06770	COG2217	Heavy metal translocating P-type atpase
I6H76_RS06775	COG2217	Heavy metal translocating P-type atpase
I6H76_RS06780	COG2801	Transposase and inactivated derivatives
I6H76_RS06795	COG3177	Filamentation induced by cAMP protein fic
I6H76_RS06825	COG2273	Hydrolase Family 16
I6H76_RS06835	COG0745	RESPONSE REGULATOR receiver
I6H76_RS06840	COG5002	protein histidine kinase activity
I6H76_RS06855	COG1696	Membrane protein involved in D-alanine export
I6H76_RS06860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6H76_RS06865	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6H76_RS06870	COG0583	DNA-binding transcription factor activity
I6H76_RS06875	COG0281	malic enzyme
I6H76_RS06885	COG2223	nitrite transmembrane transporter activity
I6H76_RS06895	COG2226	methyltransferase
I6H76_RS06905	COG0681	Belongs to the peptidase S26 family
I6H76_RS06930	COG2217	Heavy metal translocating P-type atpase
I6H76_RS06940	COG0084	hydrolase, TatD family'
I6H76_RS06960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6H76_RS06965	COG2274	protein secretion by the type I secretion system
I6H76_RS07115	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6H76_RS07120	COG1564	THIamine pyrophosphokinase
I6H76_RS07140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6H76_RS07150	COG0049	tRNA binding
I6H76_RS07155	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6H76_RS07165	COG0126	phosphoglycerate kinase activity
I6H76_RS07175	COG0789	Transcriptional regulator
I6H76_RS07180	COG0174	glutamine synthetase
I6H76_RS07185	COG0067	glutamate synthase
I6H76_RS07185	COG0069	glutamate synthase activity
I6H76_RS07185	COG0070	glutamate synthase
I6H76_RS07190	COG0493	'glutamate synthase
I6H76_RS07205	COG5503	Protein of unknown function (DUF1447)
I6H76_RS07210	COG1214	PFAM Peptidase M22, glycoprotease
I6H76_RS07215	COG0456	acetyltransferase
I6H76_RS07240	COG2081	HI0933 family
I6H76_RS07255	COG0789	Transcriptional regulator
I6H76_RS07270	COG0573	inorganic phosphate transmembrane transporter activity
I6H76_RS07275	COG0581	inorganic phosphate transmembrane transporter activity
I6H76_RS07280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6H76_RS07285	COG0704	Plays a role in the regulation of phosphate uptake
I6H76_RS07290	COG0745	RESPONSE REGULATOR receiver
I6H76_RS07295	COG5002	protein histidine kinase activity
I6H76_RS07315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6H76_RS07320	COG4619	ABC transporter
I6H76_RS07325	COG0390	transport system, permease component
I6H76_RS07365	COG1882	Formate acetyltransferase
I6H76_RS07380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6H76_RS07385	COG0681	Belongs to the peptidase S26 family
I6H76_RS07390	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6H76_RS07405	COG1193	negative regulation of DNA recombination
I6H76_RS07410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6H76_RS07420	COG0157	Belongs to the NadC ModD family
I6H76_RS07430	COG3118	belongs to the thioredoxin family
I6H76_RS07465	COG1194	a g-specific adenine glycosylase
I6H76_RS07505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6H76_RS07515	COG3655	Transcriptional regulator
I6H76_RS07550	COG0006	proline dipeptidase activity
I6H76_RS07555	COG2131	deaminase
I6H76_RS07565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6H76_RS07575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6H76_RS07580	COG1609	Transcriptional regulator
I6H76_RS07585	COG1621	beta-fructofuranosidase activity
I6H76_RS07590	COG1263	PTS System
I6H76_RS07590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6H76_RS07590	COG2190	(PTS) system
I6H76_RS07595	COG1940	carbohydrate kinase activity
I6H76_RS07605	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H76_RS07610	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6H76_RS07625	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6H76_RS07640	COG3655	Transcriptional regulator
I6H76_RS07645	COG0252	asparaginase activity
I6H76_RS07650	COG0561	phosphatase activity
I6H76_RS07655	COG0589	response to stress
I6H76_RS07665	COG0436	Aminotransferase
I6H76_RS07670	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6H76_RS07675	COG1335	isochorismatase
I6H76_RS07680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6H76_RS07685	COG0154	amidase activity
I6H76_RS07700	COG0697	spore germination
I6H76_RS07715	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6H76_RS07720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6H76_RS07725	COG1534	Rna-binding protein
I6H76_RS07730	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6H76_RS07735	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6H76_RS07740	COG0799	negative regulation of ribosome biogenesis
I6H76_RS07745	COG2226	methyltransferase
I6H76_RS07750	COG1002	Type II restriction enzyme, methylase subunits
I6H76_RS07755	COG1061	Type III restriction enzyme res subunit
I6H76_RS07760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H76_RS07765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6H76_RS07770	COG1323	Belongs to the UPF0348 family
I6H76_RS07775	COG0789	Transcriptional regulator
I6H76_RS07780	COG0217	transcriptional regulatory protein
I6H76_RS07785	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6H76_RS07790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H76_RS07795	COG1473	amidohydrolase
I6H76_RS07800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H76_RS07820	COG1114	Component of the transport system for branched-chain amino acids
I6H76_RS07825	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6H76_RS07835	COG1122	ATPase activity
I6H76_RS07850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6H76_RS07860	COG1704	LemA family
I6H76_RS07865	COG0501	Belongs to the peptidase M48B family
I6H76_RS07875	COG0745	RESPONSE REGULATOR receiver
I6H76_RS07880	COG5002	protein histidine kinase activity
I6H76_RS07895	COG1484	DNA-dependent DNA replication
I6H76_RS07925	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6H76_RS07940	COG1254	Belongs to the acylphosphatase family
I6H76_RS07945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6H76_RS07965	COG3763	UPF0154 protein
I6H76_RS07970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6H76_RS07990	COG0582	viral genome integration into host DNA
I6H76_RS08005	COG1187	pseudouridine synthase activity
I6H76_RS08010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6H76_RS08020	COG0569	domain protein
I6H76_RS08025	COG0531	amino acid
I6H76_RS08035	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6H76_RS08040	COG0671	phosphoesterase, PA-phosphatase related
I6H76_RS08045	COG1242	4 iron, 4 sulfur cluster binding
I6H76_RS08050	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6H76_RS08055	COG1119	ATPase activity
I6H76_RS08060	COG2190	(PTS) system
I6H76_RS08060	COG2211	Major facilitator Superfamily
I6H76_RS08065	COG1253	flavin adenine dinucleotide binding
I6H76_RS08070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6H76_RS08080	COG1227	inorganic diphosphatase activity
I6H76_RS08095	COG3022	response to hydroperoxide
I6H76_RS08110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H76_RS08115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6H76_RS08120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6H76_RS08125	COG1120	ATPase activity
I6H76_RS08135	COG2244	polysaccharide biosynthetic process
I6H76_RS08140	COG0626	cystathionine gamma-synthase activity
I6H76_RS08145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6H76_RS08155	COG0583	DNA-binding transcription factor activity
I6H76_RS08175	COG4471	UPF0298 protein
I6H76_RS08205	COG1227	inorganic diphosphatase activity
I6H76_RS08205	COG0517	IMP dehydrogenase activity
I6H76_RS08215	COG0470	DNA polymerase III
I6H76_RS08220	COG1774	PSP1 C-terminal conserved region
I6H76_RS08235	COG0004	ammonium transporteR
I6H76_RS08255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6H76_RS08260	COG1393	Belongs to the ArsC family
I6H76_RS08265	COG0708	Exodeoxyribonuclease III
I6H76_RS08270	COG0640	Transcriptional regulator
I6H76_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
I6H76_RS08315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6H76_RS08330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6H76_RS08345	COG1674	ftsk spoiiie
I6H76_RS08375	COG2996	Protein conserved in bacteria
I6H76_RS08385	COG4479	Belongs to the UPF0346 family
I6H76_RS08390	COG1702	phosphate starvation-inducible protein PhoH
I6H76_RS08410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6H76_RS08415	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6H76_RS08425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6H76_RS08430	COG0237	dephospho-CoA kinase activity
I6H76_RS08435	COG2814	Major facilitator Superfamily
I6H76_RS08450	COG0557	exoribonuclease II activity
I6H76_RS08460	COG1846	Transcriptional regulator
I6H76_RS08475	COG0778	Nitroreductase
I6H76_RS08490	COG1811	Na channel or pump
I6H76_RS08500	COG2816	NAD+ diphosphatase activity
I6H76_RS08505	COG0006	proline dipeptidase activity
I6H76_RS08515	COG1609	Transcriptional regulator
I6H76_RS08525	COG0438	transferase activity, transferring glycosyl groups
I6H76_RS08530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6H76_RS08540	COG4716	Myosin-crossreactive antigen
I6H76_RS08555	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H76_RS08560	COG0745	RESPONSE REGULATOR receiver
I6H76_RS08565	COG3850	Histidine kinase
I6H76_RS08565	COG5002	protein histidine kinase activity
I6H76_RS08580	COG0765	amino acid transport
I6H76_RS08585	COG0765	amino acid transport
I6H76_RS08590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H76_RS08595	COG1126	abc transporter atp-binding protein
I6H76_RS08600	COG0745	RESPONSE REGULATOR receiver
I6H76_RS08605	COG5002	protein histidine kinase activity
I6H76_RS08610	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6H76_RS08620	COG1196	nuclear chromosome segregation
I6H76_RS08635	COG0561	phosphatase activity
I6H76_RS08640	COG0561	phosphatase activity
I6H76_RS08645	COG0552	protein localization to endoplasmic reticulum
I6H76_RS08655	COG3689	TIGRFAM TIGR03943 family protein
I6H76_RS08660	COG0701	Predicted permease
I6H76_RS08670	COG2183	response to ionizing radiation
I6H76_RS08675	COG3091	SprT-like family
I6H76_RS08715	COG0826	peptidase U32
I6H76_RS08720	COG0450	alkyl hydroperoxide reductase
I6H76_RS08735	COG4443	Transcriptional Coactivator p15 (PC4)
I6H76_RS08745	COG1309	transcriptional regulator
I6H76_RS08755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6H76_RS08765	COG0588	phosphoglycerate mutase activity
I6H76_RS08785	COG0386	Belongs to the glutathione peroxidase family
I6H76_RS08790	COG1164	Oligoendopeptidase f
I6H76_RS08800	COG0772	Belongs to the SEDS family
I6H76_RS08830	COG2348	transferase activity, transferring amino-acyl groups
I6H76_RS08845	COG1078	dGTPase activity
I6H76_RS08865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6H76_RS08875	COG2884	Cell division ATP-binding protein ftsE
I6H76_RS08880	COG2177	Part of the ABC transporter FtsEX involved in
I6H76_RS08895	COG1199	ATP-dependent helicase activity
I6H76_RS08895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6H76_RS08905	COG0436	Aminotransferase
I6H76_RS08915	COG0017	Asparaginyl-tRNA synthetase
I6H76_RS08935	COG0251	oxidation-reduction process
I6H76_RS08945	COG1309	transcriptional regulator
I6H76_RS08980	COG1388	LysM domain
I6H76_RS08980	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H76_RS09010	COG0804	urea catabolic process
I6H76_RS09020	COG0830	nickel cation binding
I6H76_RS09035	COG0310	cobalt ion transport
I6H76_RS09040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6H76_RS09045	COG1122	ATPase activity
I6H76_RS09055	COG0254	rRNA binding
I6H76_RS09060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6H76_RS09065	COG1454	alcohol dehydrogenase
I6H76_RS09075	COG0716	FMN binding
I6H76_RS09085	COG0398	Pfam SNARE associated Golgi protein
I6H76_RS09095	COG0038	chloride channel
I6H76_RS09110	COG0772	Belongs to the SEDS family
I6H76_RS09120	COG0187	DNA topoisomerase II activity
I6H76_RS09135	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6H76_RS09145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6H76_RS09150	COG0560	Phosphoserine phosphatase
I6H76_RS09160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6H76_RS09170	COG0107	imidazoleglycerol-phosphate synthase activity
I6H76_RS09185	COG1523	belongs to the glycosyl hydrolase 13 family
I6H76_RS09200	COG0148	phosphopyruvate hydratase activity
I6H76_RS09205	COG3442	glutamine amidotransferase
I6H76_RS09210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6H76_RS09215	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6H76_RS09230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6H76_RS09240	COG0647	UMP catabolic process
I6H76_RS09270	COG1518	maintenance of DNA repeat elements
I6H76_RS09290	COG0481	GTPase activity
I6H76_RS09295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6H76_RS09300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6H76_RS09305	COG0077	Prephenate dehydratase
I6H76_RS09310	COG1316	TRANSCRIPTIONal
I6H76_RS09315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6H76_RS09320	COG0071	Belongs to the small heat shock protein (HSP20) family
I6H76_RS09335	COG0415	Belongs to the DNA photolyase family
I6H76_RS09420	COG1621	beta-fructofuranosidase activity
I6H76_RS09425	COG4166	transmembrane transport
I6H76_RS09430	COG4166	transmembrane transport
I6H76_RS09435	COG1187	pseudouridine synthase activity
I6H76_RS09465	COG1126	abc transporter atp-binding protein
I6H76_RS09470	COG0765	amino acid transport
I6H76_RS09480	COG2816	NAD+ diphosphatase activity
I6H76_RS09485	COG3833	ABC-type maltose transport systems, permease component
I6H76_RS09490	COG1175	transmembrane transport
I6H76_RS09500	COG1609	Transcriptional regulator
I6H76_RS09505	COG1640	4-alpha-glucanotransferase
I6H76_RS09510	COG0058	SHG alpha-glucan phosphorylase activity
I6H76_RS09520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6H76_RS09540	COG1970	mechanosensitive ion channel activity
I6H76_RS09545	COG0358	DNA primase activity
I6H76_RS09550	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6H76_RS09555	COG2151	metal-sulfur cluster biosynthetic enzyme
I6H76_RS09585	COG3754	Rhamnan synthesis protein F
I6H76_RS09590	COG1368	sulfuric ester hydrolase activity
I6H76_RS09605	COG0463	Glycosyl transferase, family 2
I6H76_RS09630	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6H76_RS09650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6H76_RS09655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6H76_RS09660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6H76_RS09665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6H76_RS09670	COG1368	sulfuric ester hydrolase activity
I6H76_RS09675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6H76_RS09685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6H76_RS09690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6H76_RS09700	COG0287	Prephenate dehydrogenase
I6H76_RS09715	COG0285	dihydrofolate synthase activity
I6H76_RS09725	COG1104	cysteine desulfurase activity
I6H76_RS09730	COG0301	tRNA thio-modification
I6H76_RS09755	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6H76_RS09765	COG0583	DNA-binding transcription factor activity
I6H76_RS09775	COG0564	pseudouridine synthase activity
I6H76_RS09790	COG0540	Belongs to the ATCase OTCase family
I6H76_RS09795	COG0505	Belongs to the CarA family
I6H76_RS09810	COG1136	(ABC) transporter
I6H76_RS09815	COG0577	efflux transmembrane transporter activity
I6H76_RS09840	COG1837	Belongs to the UPF0109 family
I6H76_RS09850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6H76_RS09865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6H76_RS09875	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6H76_RS09880	COG0492	ferredoxin-NADP+ reductase activity
I6H76_RS09890	COG1105	Belongs to the carbohydrate kinase PfkB family
I6H76_RS09895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6H76_RS09895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H76_RS09895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6H76_RS09900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6H76_RS09905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6H76_RS09905	COG0646	methionine synthase
I6H76_RS09910	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6H76_RS09915	COG1388	LysM domain
I6H76_RS09915	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6H76_RS09935	COG0617	tRNA 3'-terminal CCA addition
I6H76_RS09940	COG0488	(ABC) transporter