locus-tag	class	description
SINF_RS00010	COG0592	DNA-directed DNA polymerase activity
SINF_RS00015	COG1597	lipid kinase activity
SINF_RS00025	COG0012	GTP binding
SINF_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SINF_RS00045	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SINF_RS00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SINF_RS00175	COG1792	Involved in formation and maintenance of cell shape
SINF_RS00185	COG3942	CHAP domain
SINF_RS00200	COG0436	Aminotransferase
SINF_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SINF_RS00220	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SINF_RS00225	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SINF_RS00240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SINF_RS00245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SINF_RS00265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SINF_RS00275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SINF_RS00285	COG2255	four-way junction helicase activity
SINF_RS00295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SINF_RS00305	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SINF_RS00305	COG2755	lipolytic protein G-D-S-L family
SINF_RS00315	COG0534	Mate efflux family protein
SINF_RS00320	COG0051	transcription antitermination factor activity, RNA binding
SINF_RS00330	COG0088	Forms part of the polypeptide exit tunnel
SINF_RS00365	COG0255	Belongs to the universal ribosomal protein uL29 family
SINF_RS00380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SINF_RS00390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SINF_RS00410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SINF_RS00415	COG1841	ribosomal large subunit assembly
SINF_RS00425	COG0201	protein transport
SINF_RS00450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SINF_RS00455	COG0202	RNA polymerase activity
SINF_RS00460	COG0203	ribosomal protein L17
SINF_RS00495	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SINF_RS00505	COG1121	(ABC) transporter
SINF_RS00510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SINF_RS00600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SINF_RS00610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SINF_RS00615	COG1459	type II secretion system
SINF_RS00620	COG4537	Required for transformation and DNA binding
SINF_RS00675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SINF_RS00680	COG1363	Peptidase, m42
SINF_RS00690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SINF_RS00695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SINF_RS00710	COG2391	methyltransferase activity
SINF_RS00715	COG0425	Belongs to the sulfur carrier protein TusA family
SINF_RS00755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SINF_RS00775	COG2801	Transposase and inactivated derivatives
SINF_RS00790	COG0564	pseudouridine synthase activity
SINF_RS00820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SINF_RS00825	COG4667	esterase of the alpha-beta hydrolase superfamily
SINF_RS00840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SINF_RS00885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SINF_RS00910	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SINF_RS00915	COG1609	Transcriptional regulator
SINF_RS00920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SINF_RS00920	COG2190	(PTS) system
SINF_RS00920	COG1263	PTS System
SINF_RS00930	COG1363	Peptidase, m42
SINF_RS00940	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SINF_RS00945	COG1447	Phosphotransferase system cellobiose-specific component IIA
SINF_RS00950	COG2723	6-phospho-beta-galactosidase activity
SINF_RS00955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SINF_RS00960	COG2188	Transcriptional regulator
SINF_RS00965	COG1482	cell wall glycoprotein biosynthetic process
SINF_RS00975	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SINF_RS00985	COG2188	Transcriptional regulator
SINF_RS00990	COG1940	carbohydrate kinase activity
SINF_RS01010	COG3842	ATPase activity
SINF_RS01025	COG0698	ribose 5-phosphate isomerase
SINF_RS01055	COG2801	Transposase and inactivated derivatives
SINF_RS01060	COG3711	transcriptional antiterminator
SINF_RS01085	COG2723	6-phospho-beta-galactosidase activity
SINF_RS01100	COG2207	Transcriptional regulator
SINF_RS01105	COG3345	alpha-galactosidase
SINF_RS01110	COG1653	transport
SINF_RS01115	COG1175	transmembrane transport
SINF_RS01120	COG0395	ABC-type sugar transport system, permease component
SINF_RS01125	COG0366	Alpha amylase catalytic
SINF_RS01135	COG1609	Transcriptional regulator
SINF_RS01140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SINF_RS01145	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SINF_RS01150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SINF_RS01160	COG1862	Preprotein translocase
SINF_RS01165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SINF_RS01170	COG4589	Belongs to the CDS family
SINF_RS01220	COG1454	alcohol dehydrogenase
SINF_RS01220	COG1012	belongs to the aldehyde dehydrogenase family
SINF_RS01230	COG1185	polyribonucleotide nucleotidyltransferase activity
SINF_RS01240	COG1045	serine acetyltransferase
SINF_RS01250	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SINF_RS01255	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SINF_RS01290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SINF_RS01310	COG2217	Heavy metal translocating P-type atpase
SINF_RS01315	COG2217	Heavy metal translocating P-type atpase
SINF_RS01335	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SINF_RS01350	COG2205	protein histidine kinase activity
SINF_RS01355	COG0745	RESPONSE REGULATOR receiver
SINF_RS01360	COG2132	Multicopper oxidase
SINF_RS01370	COG2801	Transposase and inactivated derivatives
SINF_RS01385	COG2217	Heavy metal translocating P-type atpase
SINF_RS01490	COG0582	viral genome integration into host DNA
SINF_RS01540	COG3830	Belongs to the UPF0237 family
SINF_RS01550	COG0588	phosphoglycerate mutase activity
SINF_RS01555	COG1876	peptidase activity
SINF_RS01560	COG1388	LysM domain
SINF_RS01560	COG1705	Flagellar rod assembly protein muramidase FlgJ
SINF_RS01570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SINF_RS01575	COG0443	Heat shock 70 kDa protein
SINF_RS01615	COG0668	transmembrane transport
SINF_RS01630	COG0504	CTP synthase activity
SINF_RS01645	COG0191	fructose-bisphosphate aldolase activity
SINF_RS01655	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SINF_RS01665	COG1461	Dihydroxyacetone kinase
SINF_RS01670	COG0129	dihydroxy-acid dehydratase activity
SINF_RS01675	COG0028	Belongs to the TPP enzyme family
SINF_RS01680	COG0440	acetolactate synthase activity
SINF_RS01690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SINF_RS01700	COG1126	abc transporter atp-binding protein
SINF_RS01705	COG0765	amino acid transport
SINF_RS01725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SINF_RS01735	COG0719	Fe-S assembly protein
SINF_RS01740	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SINF_RS01750	COG0719	Fe-S assembly protein
SINF_RS01755	COG1686	Belongs to the peptidase S11 family
SINF_RS01760	COG4166	transmembrane transport
SINF_RS01765	COG0601	transmembrane transport
SINF_RS01770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SINF_RS01775	COG0444	Belongs to the ABC transporter superfamily
SINF_RS01780	COG4608	Belongs to the ABC transporter superfamily
SINF_RS01880	COG0527	aspartate kinase activity
SINF_RS01885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SINF_RS01890	COG1024	Enoyl-CoA hydratase
SINF_RS01900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SINF_RS01915	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SINF_RS01920	COG1028	Short-chain dehydrogenase reductase Sdr
SINF_RS01925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SINF_RS01940	COG0439	Biotin carboxylase
SINF_RS01955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SINF_RS01965	COG3716	PTS system mannose fructose sorbose family IID component
SINF_RS01970	COG3715	PTS system
SINF_RS01995	COG2252	PERMEase
SINF_RS02000	COG0802	atpase or kinase
SINF_RS02010	COG1316	TRANSCRIPTIONal
SINF_RS02020	COG0537	adenosine 5'-monophosphoramidase activity
SINF_RS02025	COG1131	(ABC) transporter
SINF_RS02030	COG4473	ABC transporter
SINF_RS02040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SINF_RS02050	COG5001	Diguanylate cyclase
SINF_RS02050	COG3300	MHYT domain
SINF_RS02075	COG0195	Participates in both transcription termination and antitermination
SINF_RS02080	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SINF_RS02090	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SINF_RS02095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SINF_RS02100	COG1611	Belongs to the LOG family
SINF_RS02115	COG2217	Heavy metal translocating P-type atpase
SINF_RS02125	COG2860	membrane
SINF_RS02130	COG0561	phosphatase activity
SINF_RS02190	COG1131	(ABC) transporter
SINF_RS02200	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SINF_RS02210	COG0275	rRNA processing
SINF_RS02220	COG0768	penicillin binding
SINF_RS02225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SINF_RS02230	COG0513	Belongs to the DEAD box helicase family
SINF_RS02235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SINF_RS02245	COG1126	abc transporter atp-binding protein
SINF_RS02255	COG0492	ferredoxin-NADP+ reductase activity
SINF_RS02260	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SINF_RS02270	COG3579	cysteine-type endopeptidase activity
SINF_RS02275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SINF_RS02280	COG3331	DNA recombination
SINF_RS02290	COG3599	regulation of cell shape
SINF_RS02300	COG0116	Belongs to the methyltransferase superfamily
SINF_RS02315	COG1854	S-ribosylhomocysteine lyase activity
SINF_RS02345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SINF_RS02345	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SINF_RS02355	COG0515	serine threonine protein kinase
SINF_RS02355	COG2815	serine threonine protein kinase
SINF_RS02365	COG4585	Histidine kinase
SINF_RS02370	COG2197	response regulator
SINF_RS02380	COG1098	S1 RNA binding domain
SINF_RS02390	COG1739	Uncharacterized protein family UPF0029
SINF_RS02400	COG1040	competence protein
SINF_RS02470	COG3557	Belongs to the UPF0374 family
SINF_RS02475	COG2137	regulation of response to DNA damage stimulus
SINF_RS02485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SINF_RS02500	COG3448	diguanylate cyclase activity
SINF_RS02500	COG4175	Glycine betaine
SINF_RS02525	COG1428	Deoxynucleoside kinase
SINF_RS02545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SINF_RS02555	COG0525	valine-tRNA ligase activity
SINF_RS02570	COG2814	Major facilitator Superfamily
SINF_RS02590	COG0742	ribosomal rna small subunit methyltransferase
SINF_RS02595	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SINF_RS02600	COG3480	Lon protease (S16) C-terminal proteolytic domain
SINF_RS02610	COG0737	Belongs to the 5'-nucleotidase family
SINF_RS02615	COG4470	Protein conserved in bacteria
SINF_RS02635	COG1132	(ABC) transporter
SINF_RS02640	COG1131	(ABC) transporter
SINF_RS02650	COG4585	Histidine kinase
SINF_RS02655	COG2197	response regulator
SINF_RS02665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SINF_RS02670	COG0512	Glutamine amidotransferase of anthranilate synthase
SINF_RS02685	COG0135	phosphoribosylanthranilate isomerase activity
SINF_RS02690	COG0133	tryptophan synthase activity
SINF_RS02695	COG0159	tryptophan synthase activity
SINF_RS02700	COG1914	H( )-stimulated, divalent metal cation uptake system
SINF_RS02720	COG1940	carbohydrate kinase activity
SINF_RS02725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SINF_RS02735	COG1217	gtp-binding protein TYPA
SINF_RS02775	COG2801	Transposase and inactivated derivatives
SINF_RS02800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SINF_RS02805	COG1799	cell septum assembly
SINF_RS02820	COG3599	regulation of cell shape
SINF_RS02855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SINF_RS02860	COG4703	Protein of unknown function (DUF1797)
SINF_RS02865	COG0765	amino acid transport
SINF_RS02870	COG1126	abc transporter atp-binding protein
SINF_RS02880	COG1918	ferrous iron import across plasma membrane
SINF_RS02880	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
SINF_RS02895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SINF_RS02925	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SINF_RS02930	COG1438	arginine binding
SINF_RS02935	COG0497	DNA recombination
SINF_RS02940	COG1307	EDD domain protein, DegV family
SINF_RS02945	COG2755	lipolytic protein G-D-S-L family
SINF_RS02950	COG4698	Protein conserved in bacteria
SINF_RS02965	COG3104	oligopeptide transport
SINF_RS02970	COG0167	dihydroorotate dehydrogenase activity
SINF_RS02975	COG0640	Transcriptional regulator
SINF_RS02980	COG2217	Heavy metal translocating P-type atpase
SINF_RS02985	COG0588	phosphoglycerate mutase activity
SINF_RS02990	COG1827	regulation of RNA biosynthetic process
SINF_RS03000	COG0768	penicillin binding
SINF_RS03005	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SINF_RS03025	COG1181	Belongs to the D-alanine--D-alanine ligase family
SINF_RS03035	COG0385	Bile acid
SINF_RS03040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SINF_RS03055	COG0513	Belongs to the DEAD box helicase family
SINF_RS03065	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SINF_RS03070	COG0204	Acyl-transferase
SINF_RS03075	COG1555	photosystem II stabilization
SINF_RS03075	COG1596	polysaccharide export
SINF_RS03080	COG0658	competence protein
SINF_RS03080	COG2333	competence protein COMEC
SINF_RS03095	COG1466	dna polymerase III delta subunit
SINF_RS03100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SINF_RS03105	COG0217	transcriptional regulatory protein
SINF_RS03110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SINF_RS03120	COG0363	glucosamine-6-phosphate deaminase activity
SINF_RS03125	COG1187	pseudouridine synthase activity
SINF_RS03145	COG0546	phosphoglycolate phosphatase activity
SINF_RS03150	COG4122	O-methyltransferase activity
SINF_RS03155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SINF_RS03160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SINF_RS03180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SINF_RS03185	COG0436	Aminotransferase
SINF_RS03195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SINF_RS03205	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SINF_RS03215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SINF_RS03215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SINF_RS03225	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SINF_RS03225	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SINF_RS03235	COG3859	Proton-coupled thiamine transporter YuaJ
SINF_RS03240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SINF_RS03245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SINF_RS03250	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SINF_RS03255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SINF_RS03260	COG0372	Belongs to the citrate synthase family
SINF_RS03300	COG0513	Belongs to the DEAD box helicase family
SINF_RS03325	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SINF_RS03330	COG0066	3-isopropylmalate dehydratase activity
SINF_RS03335	COG1956	GAF domain-containing protein
SINF_RS03340	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SINF_RS03345	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SINF_RS03345	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SINF_RS03350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SINF_RS03355	COG3708	Transcriptional regulator
SINF_RS03355	COG2207	Transcriptional regulator
SINF_RS03360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SINF_RS03365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SINF_RS03370	COG4109	DRTGG domain
SINF_RS03375	COG0024	Methionine aminopeptidase
SINF_RS03385	COG2246	polysaccharide biosynthetic process
SINF_RS03390	COG4708	membrane
SINF_RS03395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SINF_RS03400	COG1597	lipid kinase activity
SINF_RS03450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SINF_RS03480	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SINF_RS03485	COG1074	ATP-dependent DNA helicase activity
SINF_RS03510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SINF_RS03525	COG0300	oxidoreductase activity
SINF_RS03530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SINF_RS03530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SINF_RS03535	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SINF_RS03555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SINF_RS03560	COG2384	SAM-dependent methyltransferase
SINF_RS03570	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SINF_RS03580	COG1088	dTDP-glucose 4,6-dehydratase activity
SINF_RS03585	COG1051	belongs to the nudix hydrolase family
SINF_RS03590	COG0628	permease
SINF_RS03595	COG0457	Tetratricopeptide repeat
SINF_RS03605	COG0028	Belongs to the TPP enzyme family
SINF_RS03610	COG3527	Alpha-acetolactate decarboxylase
SINF_RS03615	COG0531	amino acid
SINF_RS03620	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SINF_RS03625	COG0583	DNA-binding transcription factor activity
SINF_RS03635	COG0765	amino acid transport
SINF_RS03645	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SINF_RS03655	COG4187	Peptidase family M20/M25/M40
SINF_RS03665	COG4120	Belongs to the binding-protein-dependent transport system permease family
SINF_RS03670	COG1122	ATPase activity
SINF_RS03695	COG1132	(ABC) transporter
SINF_RS03700	COG1132	(ABC) transporter
SINF_RS03710	COG0640	Transcriptional regulator
SINF_RS03715	COG2814	Major facilitator Superfamily
SINF_RS03720	COG2814	Major facilitator Superfamily
SINF_RS03735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SINF_RS03745	COG0789	Transcriptional regulator
SINF_RS03765	COG1136	(ABC) transporter
SINF_RS03770	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SINF_RS03775	COG1011	Hydrolase
SINF_RS03790	COG0583	DNA-binding transcription factor activity
SINF_RS03795	COG2855	membrane
SINF_RS03800	COG1012	belongs to the aldehyde dehydrogenase family
SINF_RS03805	COG0322	excinuclease ABC activity
SINF_RS03835	COG1573	uracil-dna glycosylase
SINF_RS03855	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SINF_RS03860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SINF_RS03890	COG1316	TRANSCRIPTIONal
SINF_RS03915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SINF_RS03945	COG1442	glycosyl transferase family 8
SINF_RS03945	COG1216	Glycosyl transferase, family 2
SINF_RS03950	COG1216	Glycosyl transferase, family 2
SINF_RS03950	COG1442	glycosyl transferase family 8
SINF_RS03970	COG0562	UDP-galactopyranose mutase
SINF_RS03980	COG0438	transferase activity, transferring glycosyl groups
SINF_RS03990	COG1091	dTDP-4-dehydrorhamnose reductase activity
SINF_RS04005	COG0167	dihydroorotate dehydrogenase activity
SINF_RS04010	COG0284	orotidine-5'-phosphate decarboxylase activity
SINF_RS04020	COG1881	PFAM PEBP family protein
SINF_RS04045	COG0187	DNA topoisomerase II activity
SINF_RS04050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SINF_RS04055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SINF_RS04075	COG0539	negative regulation of cytoplasmic translation
SINF_RS04085	COG1346	cytolysis
SINF_RS04090	COG1380	Effector of murein hydrolase LrgA
SINF_RS04105	COG1131	(ABC) transporter
SINF_RS04110	COG1725	Transcriptional regulator
SINF_RS04120	COG0205	6-phosphofructokinase activity
SINF_RS04125	COG0469	pyruvate kinase activity
SINF_RS04130	COG0582	viral genome integration into host DNA
SINF_RS04135	COG2801	Transposase and inactivated derivatives
SINF_RS04145	COG0582	viral genome integration into host DNA
SINF_RS04265	COG1783	phage Terminase large subunit
SINF_RS04385	COG2963	transposase activity
SINF_RS04390	COG2801	Transposase and inactivated derivatives
SINF_RS04405	COG2824	Alkylphosphonate utilization operon protein PhnA
SINF_RS04410	COG0765	amino acid transport
SINF_RS04415	COG1126	abc transporter atp-binding protein
SINF_RS04425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SINF_RS04430	COG1115	amino acid carrier protein
SINF_RS04435	COG2723	6-phospho-beta-galactosidase activity
SINF_RS04440	COG0406	alpha-ribazole phosphatase activity
SINF_RS04445	COG0628	permease
SINF_RS04455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SINF_RS04475	COG4116	CYTH
SINF_RS04480	COG2357	RelA SpoT domain protein
SINF_RS04490	COG0564	pseudouridine synthase activity
SINF_RS04495	COG0280	phosphate acetyltransferase
SINF_RS04500	COG4221	oxidoreductase activity
SINF_RS04525	COG2233	PERMEase
SINF_RS04550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SINF_RS04560	COG0009	L-threonylcarbamoyladenylate synthase
SINF_RS04585	COG1132	(ABC) transporter
SINF_RS04600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SINF_RS04605	COG0022	dehydrogenase e1 component
SINF_RS04605	COG0508	dehydrogenase complex catalyzes the overall conversion of
SINF_RS04610	COG0508	dehydrogenase complex catalyzes the overall conversion of
SINF_RS04625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SINF_RS04630	COG0095	Lipoate-protein ligase
SINF_RS04655	COG1937	Protein conserved in bacteria
SINF_RS04665	COG0446	pyridine nucleotide-disulphide oxidoreductase
SINF_RS04670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SINF_RS04675	COG1418	mRNA catabolic process
SINF_RS04685	COG0519	Catalyzes the synthesis of GMP from XMP
SINF_RS04685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SINF_RS04690	COG0494	nUDIX hydrolase
SINF_RS04730	COG1396	sequence-specific DNA binding
SINF_RS04735	COG5263	repeat protein
SINF_RS04735	COG0366	Alpha amylase catalytic
SINF_RS04750	COG0534	Mate efflux family protein
SINF_RS04755	COG1461	Dihydroxyacetone kinase
SINF_RS04760	COG1461	Dihydroxyacetone kinase
SINF_RS04765	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SINF_RS04780	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SINF_RS04810	COG2188	Transcriptional regulator
SINF_RS04820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SINF_RS04830	COG2207	Transcriptional regulator
SINF_RS04835	COG4974	Belongs to the 'phage' integrase family
SINF_RS04845	COG5002	protein histidine kinase activity
SINF_RS04850	COG0745	RESPONSE REGULATOR receiver
SINF_RS04855	COG0577	efflux transmembrane transporter activity
SINF_RS04860	COG1136	(ABC) transporter
SINF_RS04890	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SINF_RS04895	COG0758	DNA mediated transformation
SINF_RS04900	COG0110	maltose O-acetyltransferase activity
SINF_RS04905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SINF_RS04910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SINF_RS04950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SINF_RS04995	COG1131	(ABC) transporter
SINF_RS05025	COG3250	beta-galactosidase activity
SINF_RS05030	COG2211	Major facilitator Superfamily
SINF_RS05030	COG2190	(PTS) system
SINF_RS05035	COG2017	converts alpha-aldose to the beta-anomer
SINF_RS05040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SINF_RS05050	COG1573	uracil-dna glycosylase
SINF_RS05095	COG1131	(ABC) transporter
SINF_RS05100	COG0488	(ABC) transporter
SINF_RS05115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SINF_RS05120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SINF_RS05125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SINF_RS05130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SINF_RS05145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SINF_RS05150	COG4684	Psort location CytoplasmicMembrane, score
SINF_RS05155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SINF_RS05175	COG0346	lactoylglutathione lyase activity
SINF_RS05180	COG3764	Sortase (surface protein transpeptidase)
SINF_RS05200	COG1079	Belongs to the binding-protein-dependent transport system permease family
SINF_RS05205	COG4603	Belongs to the binding-protein-dependent transport system permease family
SINF_RS05210	COG3845	ABC transporter
SINF_RS05215	COG1744	ABC transporter substrate-binding protein PnrA-like
SINF_RS05225	COG2813	Specifically methylates the guanine in position
SINF_RS05230	COG1072	(Pantothenic acid kinase))
SINF_RS05240	COG2801	Transposase and inactivated derivatives
SINF_RS05250	COG5002	protein histidine kinase activity
SINF_RS05255	COG0745	RESPONSE REGULATOR receiver
SINF_RS05265	COG0704	Plays a role in the regulation of phosphate uptake
SINF_RS05270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SINF_RS05280	COG0581	inorganic phosphate transmembrane transporter activity
SINF_RS05285	COG0573	inorganic phosphate transmembrane transporter activity
SINF_RS05295	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SINF_RS05295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SINF_RS05300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SINF_RS05320	COG0483	inositol monophosphate 1-phosphatase activity
SINF_RS05325	COG4476	Belongs to the UPF0223 family
SINF_RS05330	COG1393	Belongs to the ArsC family
SINF_RS05335	COG0196	riboflavin kinase activity
SINF_RS05340	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SINF_RS05370	COG0577	efflux transmembrane transporter activity
SINF_RS05370	COG1136	(ABC) transporter
SINF_RS05390	COG2873	o-acetylhomoserine
SINF_RS05400	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SINF_RS05410	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SINF_RS05455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SINF_RS05460	COG1115	amino acid carrier protein
SINF_RS05465	COG0561	phosphatase activity
SINF_RS05475	COG2723	6-phospho-beta-galactosidase activity
SINF_RS05485	COG0561	phosphatase activity
SINF_RS05500	COG0110	maltose O-acetyltransferase activity
SINF_RS05555	COG3711	transcriptional antiterminator
SINF_RS05560	COG0038	chloride channel
SINF_RS05595	COG1054	Belongs to the UPF0176 family
SINF_RS05600	COG4720	Psort location CytoplasmicMembrane, score
SINF_RS05620	COG1177	transmembrane transport
SINF_RS05625	COG1176	ABC-type spermidine putrescine transport system, permease component I
SINF_RS05635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SINF_RS05660	COG0285	dihydrofolate synthase activity
SINF_RS05665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SINF_RS05670	COG2962	Rard protein
SINF_RS05690	COG2801	Transposase and inactivated derivatives
SINF_RS05705	COG1309	transcriptional regulator
SINF_RS05740	COG2040	homocysteine
SINF_RS05745	COG0833	amino acid
SINF_RS05765	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SINF_RS05770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SINF_RS05775	COG3425	synthase
SINF_RS05790	COG1272	protein, Hemolysin III
SINF_RS05820	COG1126	abc transporter atp-binding protein
SINF_RS05825	COG4215	(ABC) transporter
SINF_RS05830	COG0765	amino acid transport
SINF_RS05835	COG1126	abc transporter atp-binding protein
SINF_RS05840	COG0765	amino acid transport
SINF_RS05845	COG0765	amino acid transport
SINF_RS05850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SINF_RS05865	COG0583	DNA-binding transcription factor activity
SINF_RS05870	COG0656	L-ascorbic acid biosynthetic process
SINF_RS05875	COG5002	protein histidine kinase activity
SINF_RS05880	COG0745	RESPONSE REGULATOR receiver
SINF_RS05885	COG2357	RelA SpoT domain protein
SINF_RS05890	COG1132	(ABC) transporter
SINF_RS05905	COG0242	peptide deformylase activity
SINF_RS05910	COG1247	-acetyltransferase
SINF_RS05915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SINF_RS05925	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SINF_RS05930	COG0602	queuosine metabolic process
SINF_RS05935	COG0720	synthase
SINF_RS05940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SINF_RS05945	COG1132	(ABC) transporter
SINF_RS05955	COG0488	(ABC) transporter
SINF_RS05960	COG0617	tRNA 3'-terminal CCA addition
SINF_RS05980	COG1705	Flagellar rod assembly protein muramidase FlgJ
SINF_RS05980	COG1388	LysM domain
SINF_RS05985	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SINF_RS05990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SINF_RS05990	COG0646	methionine synthase
SINF_RS05995	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SINF_RS06000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SINF_RS06000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SINF_RS06000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SINF_RS06005	COG1105	Belongs to the carbohydrate kinase PfkB family
SINF_RS06015	COG0492	ferredoxin-NADP+ reductase activity
SINF_RS06020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SINF_RS06030	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SINF_RS06045	COG1837	Belongs to the UPF0109 family
SINF_RS06070	COG0577	efflux transmembrane transporter activity
SINF_RS06075	COG1136	(ABC) transporter
SINF_RS06090	COG0505	Belongs to the CarA family
SINF_RS06095	COG0540	Belongs to the ATCase OTCase family
SINF_RS06110	COG0564	pseudouridine synthase activity
SINF_RS06120	COG0583	DNA-binding transcription factor activity
SINF_RS06125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SINF_RS06150	COG0301	tRNA thio-modification
SINF_RS06165	COG0285	dihydrofolate synthase activity
SINF_RS06180	COG0287	Prephenate dehydrogenase
SINF_RS06190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SINF_RS06195	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SINF_RS06205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SINF_RS06210	COG1368	sulfuric ester hydrolase activity
SINF_RS06215	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SINF_RS06220	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SINF_RS06225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SINF_RS06230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SINF_RS06250	COG2195	Cleaves the N-terminal amino acid of tripeptides
SINF_RS06265	COG3942	CHAP domain
SINF_RS06270	COG0463	Glycosyl transferase, family 2
SINF_RS06290	COG1368	sulfuric ester hydrolase activity
SINF_RS06300	COG3754	Rhamnan synthesis protein F
SINF_RS06330	COG2151	metal-sulfur cluster biosynthetic enzyme
SINF_RS06335	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SINF_RS06340	COG0358	DNA primase activity
SINF_RS06345	COG1970	mechanosensitive ion channel activity
SINF_RS06370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SINF_RS06385	COG1640	4-alpha-glucanotransferase
SINF_RS06390	COG1609	Transcriptional regulator
SINF_RS06400	COG1175	transmembrane transport
SINF_RS06405	COG3833	ABC-type maltose transport systems, permease component
SINF_RS06410	COG2816	NAD+ diphosphatase activity
SINF_RS06420	COG0765	amino acid transport
SINF_RS06425	COG1126	abc transporter atp-binding protein
SINF_RS06450	COG1187	pseudouridine synthase activity
SINF_RS06455	COG4166	transmembrane transport
SINF_RS06460	COG4166	transmembrane transport
SINF_RS06465	COG1621	beta-fructofuranosidase activity
SINF_RS06480	COG0454	-acetyltransferase
SINF_RS06525	COG0071	Belongs to the small heat shock protein (HSP20) family
SINF_RS06530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SINF_RS06535	COG1316	TRANSCRIPTIONal
SINF_RS06540	COG0077	Prephenate dehydratase
SINF_RS06545	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SINF_RS06550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SINF_RS06555	COG0481	GTPase activity
SINF_RS06590	COG1518	maintenance of DNA repeat elements
SINF_RS06595	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SINF_RS06610	COG0647	UMP catabolic process
SINF_RS06620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SINF_RS06635	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SINF_RS06640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SINF_RS06645	COG3442	glutamine amidotransferase
SINF_RS06650	COG0148	phosphopyruvate hydratase activity
SINF_RS06665	COG1523	belongs to the glycosyl hydrolase 13 family
SINF_RS06680	COG0107	imidazoleglycerol-phosphate synthase activity
SINF_RS06690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SINF_RS06700	COG0560	Phosphoserine phosphatase
SINF_RS06705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SINF_RS06715	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SINF_RS06730	COG0187	DNA topoisomerase II activity
SINF_RS06745	COG0772	Belongs to the SEDS family
SINF_RS06760	COG0038	chloride channel
SINF_RS06770	COG0398	Pfam SNARE associated Golgi protein
SINF_RS06780	COG0716	FMN binding
SINF_RS06800	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SINF_RS06810	COG1388	LysM domain
SINF_RS06810	COG1705	Flagellar rod assembly protein muramidase FlgJ
SINF_RS06835	COG1660	Displays ATPase and GTPase activities
SINF_RS06845	COG1309	transcriptional regulator
SINF_RS06855	COG0251	oxidation-reduction process
SINF_RS06875	COG0017	Asparaginyl-tRNA synthetase
SINF_RS06885	COG0436	Aminotransferase
SINF_RS06895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SINF_RS06895	COG1199	ATP-dependent helicase activity
SINF_RS06910	COG2177	Part of the ABC transporter FtsEX involved in
SINF_RS06915	COG2884	Cell division ATP-binding protein ftsE
SINF_RS06920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SINF_RS06925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SINF_RS06945	COG1078	dGTPase activity
SINF_RS06975	COG0772	Belongs to the SEDS family
SINF_RS06985	COG1164	Oligoendopeptidase f
SINF_RS06990	COG0386	Belongs to the glutathione peroxidase family
SINF_RS07010	COG0588	phosphoglycerate mutase activity
SINF_RS07025	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SINF_RS07030	COG1396	sequence-specific DNA binding
SINF_RS07035	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SINF_RS07075	COG2963	transposase activity
SINF_RS07080	COG2801	Transposase and inactivated derivatives
SINF_RS07120	COG1674	ftsk spoiiie
SINF_RS07150	COG0433	COG0433 Predicted ATPase
SINF_RS07165	COG3942	CHAP domain
SINF_RS07185	COG1309	transcriptional regulator
SINF_RS07195	COG4443	Transcriptional Coactivator p15 (PC4)
SINF_RS07205	COG0826	peptidase U32
SINF_RS07250	COG3091	SprT-like family
SINF_RS07255	COG2183	response to ionizing radiation
SINF_RS07265	COG0701	Predicted permease
SINF_RS07270	COG3689	TIGRFAM TIGR03943 family protein
SINF_RS07280	COG0552	protein localization to endoplasmic reticulum
SINF_RS07285	COG0561	phosphatase activity
SINF_RS07290	COG0561	phosphatase activity
SINF_RS07305	COG1196	nuclear chromosome segregation
SINF_RS07315	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SINF_RS07320	COG5002	protein histidine kinase activity
SINF_RS07325	COG0745	RESPONSE REGULATOR receiver
SINF_RS07330	COG1126	abc transporter atp-binding protein
SINF_RS07335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SINF_RS07340	COG0765	amino acid transport
SINF_RS07345	COG0765	amino acid transport
SINF_RS07360	COG3850	Histidine kinase
SINF_RS07360	COG5002	protein histidine kinase activity
SINF_RS07365	COG0745	RESPONSE REGULATOR receiver
SINF_RS07385	COG4716	Myosin-crossreactive antigen
SINF_RS07395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SINF_RS07400	COG0438	transferase activity, transferring glycosyl groups
SINF_RS07410	COG1609	Transcriptional regulator
SINF_RS07420	COG0006	proline dipeptidase activity
SINF_RS07425	COG2816	NAD+ diphosphatase activity
SINF_RS07430	COG0583	DNA-binding transcription factor activity
SINF_RS07435	COG1811	Na channel or pump
SINF_RS07450	COG0778	Nitroreductase
SINF_RS07475	COG0557	exoribonuclease II activity
SINF_RS07485	COG2814	Major facilitator Superfamily
SINF_RS07490	COG0237	dephospho-CoA kinase activity
SINF_RS07495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SINF_RS07505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SINF_RS07510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SINF_RS07530	COG1702	phosphate starvation-inducible protein PhoH
SINF_RS07535	COG4479	Belongs to the UPF0346 family
SINF_RS07545	COG2996	Protein conserved in bacteria
SINF_RS07605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SINF_RS07620	COG1028	Short-chain dehydrogenase reductase Sdr
SINF_RS07650	COG0640	Transcriptional regulator
SINF_RS07655	COG0708	Exodeoxyribonuclease III
SINF_RS07660	COG1393	Belongs to the ArsC family
SINF_RS07665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SINF_RS07685	COG0004	ammonium transporteR
SINF_RS07700	COG1774	PSP1 C-terminal conserved region
SINF_RS07705	COG0470	DNA polymerase III
SINF_RS07715	COG1227	inorganic diphosphatase activity
SINF_RS07715	COG0517	IMP dehydrogenase activity
SINF_RS07745	COG4471	UPF0298 protein
SINF_RS07765	COG0583	DNA-binding transcription factor activity
SINF_RS07775	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SINF_RS07780	COG0626	cystathionine gamma-synthase activity
SINF_RS07785	COG2244	polysaccharide biosynthetic process
SINF_RS07795	COG1120	ATPase activity
SINF_RS07800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SINF_RS07805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SINF_RS07810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SINF_RS07825	COG3022	response to hydroperoxide
SINF_RS07840	COG1227	inorganic diphosphatase activity
SINF_RS07850	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SINF_RS07855	COG1253	flavin adenine dinucleotide binding
SINF_RS07860	COG2190	(PTS) system
SINF_RS07860	COG2211	Major facilitator Superfamily
SINF_RS07865	COG1119	ATPase activity
SINF_RS07900	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SINF_RS07905	COG1242	4 iron, 4 sulfur cluster binding
SINF_RS07910	COG0671	phosphoesterase, PA-phosphatase related
SINF_RS07915	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SINF_RS07925	COG0531	amino acid
SINF_RS07930	COG0569	domain protein
SINF_RS07940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SINF_RS07945	COG1187	pseudouridine synthase activity
SINF_RS07960	COG0582	viral genome integration into host DNA
SINF_RS07980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SINF_RS07985	COG3763	UPF0154 protein
SINF_RS08005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SINF_RS08010	COG1254	Belongs to the acylphosphatase family
SINF_RS08025	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SINF_RS08055	COG1484	DNA-dependent DNA replication
SINF_RS08070	COG5002	protein histidine kinase activity
SINF_RS08075	COG0745	RESPONSE REGULATOR receiver
SINF_RS08085	COG0501	Belongs to the peptidase M48B family
SINF_RS08090	COG1704	LemA family
SINF_RS08100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SINF_RS08115	COG1122	ATPase activity
SINF_RS08125	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SINF_RS08130	COG1114	Component of the transport system for branched-chain amino acids
SINF_RS08140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SINF_RS08150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SINF_RS08155	COG1473	amidohydrolase
SINF_RS08165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SINF_RS08170	COG0217	transcriptional regulatory protein
SINF_RS08175	COG0789	Transcriptional regulator
SINF_RS08180	COG1323	Belongs to the UPF0348 family
SINF_RS08185	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SINF_RS08190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SINF_RS08195	COG1061	Type III restriction enzyme res subunit
SINF_RS08200	COG1002	Type II restriction enzyme, methylase subunits
SINF_RS08205	COG2226	methyltransferase
SINF_RS08210	COG0799	negative regulation of ribosome biogenesis
SINF_RS08215	COG1335	isochorismatase
SINF_RS08220	COG1713	HD superfamily hydrolase involved in NAD metabolism
SINF_RS08230	COG1534	Rna-binding protein
SINF_RS08235	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SINF_RS08240	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SINF_RS08270	COG0154	amidase activity
SINF_RS08275	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SINF_RS08280	COG1335	isochorismatase
SINF_RS08285	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SINF_RS08290	COG0436	Aminotransferase
SINF_RS08310	COG0561	phosphatase activity
SINF_RS08315	COG0252	asparaginase activity
SINF_RS08320	COG3655	Transcriptional regulator
SINF_RS08340	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SINF_RS08355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SINF_RS08360	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SINF_RS08370	COG1940	carbohydrate kinase activity
SINF_RS08375	COG1263	PTS System
SINF_RS08375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SINF_RS08375	COG2190	(PTS) system
SINF_RS08380	COG1621	beta-fructofuranosidase activity
SINF_RS08385	COG1609	Transcriptional regulator
SINF_RS08390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SINF_RS08400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SINF_RS08410	COG2131	deaminase
SINF_RS08415	COG0006	proline dipeptidase activity
SINF_RS08445	COG3655	Transcriptional regulator
SINF_RS08455	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SINF_RS08500	COG1194	a g-specific adenine glycosylase
SINF_RS08540	COG3118	belongs to the thioredoxin family
SINF_RS08550	COG0157	Belongs to the NadC ModD family
SINF_RS08560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SINF_RS08565	COG1193	negative regulation of DNA recombination
SINF_RS08580	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SINF_RS08585	COG0681	Belongs to the peptidase S26 family
SINF_RS08590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SINF_RS08605	COG1882	Formate acetyltransferase
SINF_RS08655	COG0390	transport system, permease component
SINF_RS08660	COG4619	ABC transporter
SINF_RS08670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SINF_RS08690	COG5002	protein histidine kinase activity
SINF_RS08700	COG0704	Plays a role in the regulation of phosphate uptake
SINF_RS08705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SINF_RS08710	COG0581	inorganic phosphate transmembrane transporter activity
SINF_RS08715	COG0573	inorganic phosphate transmembrane transporter activity
SINF_RS08730	COG0789	Transcriptional regulator
SINF_RS08745	COG2081	HI0933 family
SINF_RS08770	COG0456	acetyltransferase
SINF_RS08775	COG1214	PFAM Peptidase M22, glycoprotease
SINF_RS08780	COG5503	Protein of unknown function (DUF1447)
SINF_RS08795	COG0493	'glutamate synthase
SINF_RS08800	COG0070	glutamate synthase
SINF_RS08800	COG0069	glutamate synthase activity
SINF_RS08800	COG0067	glutamate synthase
SINF_RS08805	COG0174	glutamine synthetase
SINF_RS08810	COG0789	Transcriptional regulator
SINF_RS08820	COG0126	phosphoglycerate kinase activity
SINF_RS08830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SINF_RS08835	COG0049	tRNA binding
SINF_RS08845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SINF_RS08865	COG1564	THIamine pyrophosphokinase
SINF_RS08870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SINF_RS08960	COG2274	protein secretion by the type I secretion system
SINF_RS08965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SINF_RS08985	COG0084	hydrolase, TatD family'
SINF_RS09000	COG2801	Transposase and inactivated derivatives
SINF_RS09010	COG2217	Heavy metal translocating P-type atpase
SINF_RS09030	COG0681	Belongs to the peptidase S26 family
SINF_RS09050	COG2223	nitrite transmembrane transporter activity
SINF_RS09060	COG0281	malic enzyme
SINF_RS09065	COG0583	DNA-binding transcription factor activity
SINF_RS09070	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SINF_RS09075	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SINF_RS09080	COG1696	Membrane protein involved in D-alanine export
SINF_RS09095	COG5002	protein histidine kinase activity
SINF_RS09100	COG0745	RESPONSE REGULATOR receiver
SINF_RS09110	COG2273	Hydrolase Family 16
SINF_RS09155	COG3177	Filamentation induced by cAMP protein fic
SINF_RS09160	COG2801	Transposase and inactivated derivatives
SINF_RS09170	COG2801	Transposase and inactivated derivatives
SINF_RS09175	COG2801	Transposase and inactivated derivatives
SINF_RS09180	COG2963	transposase activity
SINF_RS09215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SINF_RS09225	COG3843	relaxase mobilization nuclease domain protein
SINF_RS09250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SINF_RS09250	COG0551	DNA topoisomerase type I activity
SINF_RS09275	COG0629	single-stranded DNA binding
SINF_RS09355	COG1131	(ABC) transporter
SINF_RS09370	COG0594	ribonuclease P activity
SINF_RS09380	COG0137	argininosuccinate synthase activity
SINF_RS09390	COG0444	Belongs to the ABC transporter superfamily
SINF_RS09395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SINF_RS09400	COG0601	transmembrane transport
SINF_RS09405	COG4166	transmembrane transport
SINF_RS09410	COG2807	transmembrane transport
SINF_RS09415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SINF_RS09425	COG4989	oxidoreductase activity
SINF_RS09440	COG0756	dUTP diphosphatase activity
SINF_RS09455	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SINF_RS09465	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SINF_RS09475	COG2171	N-acyltransferase activity
SINF_RS09490	COG0166	Belongs to the GPI family
SINF_RS09500	COG1234	tRNA 3'-trailer cleavage
SINF_RS09505	COG1268	BioY protein
SINF_RS09510	COG0343	queuine tRNA-ribosyltransferase activity
SINF_RS09525	COG1832	CoA-binding protein
SINF_RS09530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SINF_RS09530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SINF_RS09545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SINF_RS09550	COG2918	glutathione biosynthetic process
SINF_RS09550	COG1181	Belongs to the D-alanine--D-alanine ligase family
SINF_RS09565	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SINF_RS09570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SINF_RS09575	COG0542	response to heat
SINF_RS09580	COG4463	regulation of RNA biosynthetic process
SINF_RS09590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SINF_RS09610	COG1619	proteins homologs of microcin C7 resistance protein MccF
SINF_RS09645	COG1396	sequence-specific DNA binding
SINF_RS09650	COG3590	peptidase
SINF_RS09665	COG0681	Belongs to the peptidase S26 family
SINF_RS09680	COG0602	queuosine metabolic process
SINF_RS09690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SINF_RS09690	COG1328	CTP reductase activity
SINF_RS09710	COG4472	Bacterial protein of unknown function (DUF965)
SINF_RS09715	COG1393	Belongs to the ArsC family
SINF_RS09725	COG1546	Belongs to the CinA family
SINF_RS09725	COG1058	Belongs to the CinA family
SINF_RS09735	COG0519	Catalyzes the synthesis of GMP from XMP
SINF_RS09780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SINF_RS09785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SINF_RS09805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SINF_RS09840	COG1597	lipid kinase activity
SINF_RS09855	COG2261	transglycosylase associated protein
SINF_RS09870	COG2801	Transposase and inactivated derivatives
SINF_RS09875	COG3759	membrane
SINF_RS09880	COG1511	domain protein
SINF_RS09885	COG1309	transcriptional regulator
SINF_RS09895	COG4466	Protein conserved in bacteria
SINF_RS09900	COG0305	Participates in initiation and elongation during chromosome replication
SINF_RS09915	COG0445	tRNA wobble uridine modification
SINF_RS09930	COG1760	l-serine dehydratase
SINF_RS09935	COG1760	l-serine dehydratase
SINF_RS09945	COG0741	lytic transglycosylase activity
SINF_RS09960	COG1122	ATPase activity
SINF_RS09980	COG0612	Peptidase, M16
SINF_RS09985	COG0612	Peptidase, M16
SINF_RS09995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SINF_RS10005	COG0516	GMP reductase activity
SINF_RS10005	COG0517	IMP dehydrogenase activity
SINF_RS10020	COG0488	(ABC) transporter
SINF_RS10035	COG2801	Transposase and inactivated derivatives
SINF_RS10060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SINF_RS10065	COG1475	DNA binding
SINF_RS10160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins