locus-tag	class	description
GOM46_RS00010	COG0592	DNA-directed DNA polymerase activity
GOM46_RS00020	COG0012	GTP binding
GOM46_RS00080	COG0756	dUTP diphosphatase activity
GOM46_RS00100	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GOM46_RS00115	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GOM46_RS00130	COG1832	CoA-binding protein
GOM46_RS00135	COG2855	membrane
GOM46_RS00140	COG0436	Aminotransferase
GOM46_RS00155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GOM46_RS00165	COG1739	Uncharacterized protein family UPF0029
GOM46_RS00170	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GOM46_RS00175	COG1040	competence protein
GOM46_RS00185	COG1960	acyl-CoA dehydrogenase activity
GOM46_RS00190	COG1250	3-hydroxyacyl-CoA dehydrogenase
GOM46_RS00195	COG0183	Belongs to the thiolase family
GOM46_RS00200	COG1024	Enoyl-CoA hydratase
GOM46_RS00210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GOM46_RS00215	COG0583	DNA-binding transcription factor activity
GOM46_RS00220	COG1960	acyl-CoA dehydrogenase activity
GOM46_RS00225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GOM46_RS00230	COG2070	2-Nitropropane dioxygenase
GOM46_RS00245	COG0305	Participates in initiation and elongation during chromosome replication
GOM46_RS00260	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GOM46_RS00260	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GOM46_RS00265	COG0531	amino acid
GOM46_RS00270	COG3537	Alpha-1,2-mannosidase
GOM46_RS00285	COG0383	alpha-mannosidase activity
GOM46_RS00300	COG4209	transmembrane transport
GOM46_RS00305	COG0395	ABC-type sugar transport system, permease component
GOM46_RS00310	COG1653	transport
GOM46_RS00365	COG1695	Transcriptional regulator
GOM46_RS00400	COG1760	l-serine dehydratase
GOM46_RS00405	COG1760	l-serine dehydratase
GOM46_RS00410	COG1388	LysM domain
GOM46_RS00410	COG3584	3D domain protein
GOM46_RS00425	COG0494	nUDIX hydrolase
GOM46_RS00430	COG0445	tRNA wobble uridine modification
GOM46_RS00440	COG1328	CTP reductase activity
GOM46_RS00475	COG0088	Forms part of the polypeptide exit tunnel
GOM46_RS00490	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GOM46_RS00505	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GOM46_RS00515	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GOM46_RS00535	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GOM46_RS00555	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GOM46_RS00570	COG0201	protein transport
GOM46_RS00580	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GOM46_RS00585	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GOM46_RS00595	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GOM46_RS00600	COG0202	RNA polymerase activity
GOM46_RS00610	COG3830	Belongs to the UPF0237 family
GOM46_RS00615	COG2848	UPF0210 protein
GOM46_RS00625	COG0706	membrane insertase activity
GOM46_RS00640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GOM46_RS00645	COG1862	Preprotein translocase
GOM46_RS00660	COG1012	belongs to the aldehyde dehydrogenase family
GOM46_RS00660	COG1454	alcohol dehydrogenase
GOM46_RS00670	COG1136	(ABC) transporter
GOM46_RS00675	COG0577	efflux transmembrane transporter activity
GOM46_RS00685	COG0564	pseudouridine synthase activity
GOM46_RS00690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GOM46_RS00775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GOM46_RS00780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GOM46_RS00790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GOM46_RS00795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GOM46_RS00805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GOM46_RS00810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GOM46_RS00815	COG1116	anion transmembrane transporter activity
GOM46_RS00825	COG4463	regulation of RNA biosynthetic process
GOM46_RS00830	COG0542	response to heat
GOM46_RS00855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GOM46_RS00875	COG1696	Membrane protein involved in D-alanine export
GOM46_RS00885	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GOM46_RS00890	COG1846	Transcriptional regulator
GOM46_RS00895	COG1121	(ABC) transporter
GOM46_RS00900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GOM46_RS00905	COG3443	Belongs to the bacterial solute-binding protein 9 family
GOM46_RS00905	COG0803	Belongs to the bacterial solute-binding protein 9 family
GOM46_RS00910	COG2514	catechol 2,3-dioxygenase activity
GOM46_RS00920	COG1937	Protein conserved in bacteria
GOM46_RS00925	COG0425	Belongs to the sulfur carrier protein TusA family
GOM46_RS00925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GOM46_RS00930	COG0446	pyridine nucleotide-disulphide oxidoreductase
GOM46_RS00935	COG0425	Belongs to the sulfur carrier protein TusA family
GOM46_RS00935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GOM46_RS00955	COG0110	maltose O-acetyltransferase activity
GOM46_RS00965	COG3237	CsbD-like
GOM46_RS00970	COG2323	membrane
GOM46_RS01115	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GOM46_RS01120	COG1459	type II secretion system
GOM46_RS01125	COG4537	Required for transformation and DNA binding
GOM46_RS01150	COG0588	phosphoglycerate mutase activity
GOM46_RS01155	COG1132	(ABC) transporter
GOM46_RS01160	COG1132	(ABC) transporter
GOM46_RS01165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GOM46_RS01170	COG0166	Belongs to the GPI family
GOM46_RS01190	COG3730	PTS system glucitol sorbitol-specific
GOM46_RS01195	COG3732	PTS system glucitol sorbitol-specific
GOM46_RS01215	COG0436	Aminotransferase
GOM46_RS01225	COG0531	amino acid
GOM46_RS01230	COG0084	hydrolase, TatD family'
GOM46_RS01255	COG1162	GTPase activity
GOM46_RS01275	COG3481	metal-dependent phosphohydrolase, HD sub domain
GOM46_RS01280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GOM46_RS01290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GOM46_RS01300	COG1254	Belongs to the acylphosphatase family
GOM46_RS01305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GOM46_RS01320	COG0742	ribosomal rna small subunit methyltransferase
GOM46_RS01330	COG3480	Lon protease (S16) C-terminal proteolytic domain
GOM46_RS01340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GOM46_RS01355	COG1253	flavin adenine dinucleotide binding
GOM46_RS01365	COG4166	transmembrane transport
GOM46_RS01370	COG0601	transmembrane transport
GOM46_RS01375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GOM46_RS01380	COG0444	Belongs to the ABC transporter superfamily
GOM46_RS01385	COG4608	Belongs to the ABC transporter superfamily
GOM46_RS01410	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GOM46_RS01420	COG0517	IMP dehydrogenase activity
GOM46_RS01440	COG1187	pseudouridine synthase activity
GOM46_RS01450	COG1363	Peptidase, m42
GOM46_RS01465	COG0126	phosphoglycerate kinase activity
GOM46_RS01470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GOM46_RS01475	COG0285	dihydrofolate synthase activity
GOM46_RS01485	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GOM46_RS01485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GOM46_RS01500	COG1609	Transcriptional regulator
GOM46_RS01505	COG0252	asparaginase activity
GOM46_RS01510	COG0561	phosphatase activity
GOM46_RS01530	COG0589	response to stress
GOM46_RS01540	COG1959	2 iron, 2 sulfur cluster binding
GOM46_RS01545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GOM46_RS01545	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GOM46_RS01550	COG3942	CHAP domain
GOM46_RS01565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GOM46_RS01565	COG5549	protein import
GOM46_RS01580	COG4839	cell division protein FtsL
GOM46_RS01585	COG0768	penicillin binding
GOM46_RS01600	COG0789	Transcriptional regulator
GOM46_RS01605	COG0174	glutamine synthetase
GOM46_RS01630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GOM46_RS01640	COG0484	heat shock protein binding
GOM46_RS01655	COG0537	adenosine 5'-monophosphoramidase activity
GOM46_RS01660	COG1131	(ABC) transporter
GOM46_RS01685	COG0195	Participates in both transcription termination and antitermination
GOM46_RS01690	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GOM46_RS01735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GOM46_RS01740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GOM46_RS01745	COG4221	oxidoreductase activity
GOM46_RS01760	COG4585	Histidine kinase
GOM46_RS01765	COG2197	response regulator
GOM46_RS01790	COG3716	PTS system mannose fructose sorbose family IID component
GOM46_RS01820	COG0527	aspartate kinase activity
GOM46_RS01825	COG1024	Enoyl-CoA hydratase
GOM46_RS01830	COG1846	Transcriptional regulator
GOM46_RS01840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GOM46_RS01850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GOM46_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
GOM46_RS01860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GOM46_RS01875	COG0439	Biotin carboxylase
GOM46_RS01880	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GOM46_RS01920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GOM46_RS01945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GOM46_RS01960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GOM46_RS01965	COG0569	domain protein
GOM46_RS01975	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GOM46_RS01980	COG0671	phosphoesterase, PA-phosphatase related
GOM46_RS02000	COG0028	Belongs to the TPP enzyme family
GOM46_RS02005	COG0440	acetolactate synthase activity
GOM46_RS02010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GOM46_RS02015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GOM46_RS02035	COG0765	amino acid transport
GOM46_RS02050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GOM46_RS02055	COG1882	Formate acetyltransferase
GOM46_RS02070	COG4166	transmembrane transport
GOM46_RS02075	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GOM46_RS02100	COG0116	Belongs to the methyltransferase superfamily
GOM46_RS02110	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GOM46_RS02115	COG0745	RESPONSE REGULATOR receiver
GOM46_RS02145	COG4585	Histidine kinase
GOM46_RS02150	COG2197	response regulator
GOM46_RS02155	COG0544	peptidyl-prolyl cis-trans isomerase activity
GOM46_RS02160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GOM46_RS02165	COG0681	Belongs to the peptidase S26 family
GOM46_RS02185	COG1193	negative regulation of DNA recombination
GOM46_RS02200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GOM46_RS02215	COG1573	uracil-dna glycosylase
GOM46_RS02225	COG1114	Component of the transport system for branched-chain amino acids
GOM46_RS02235	COG1363	Peptidase, m42
GOM46_RS02255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GOM46_RS02255	COG0072	phenylalanine-tRNA ligase activity
GOM46_RS02260	COG4152	abc transporter atp-binding protein
GOM46_RS02265	COG1668	transmembrane transport
GOM46_RS02275	COG0504	CTP synthase activity
GOM46_RS02300	COG0431	NADPH-dependent FMN reductase
GOM46_RS02310	COG0436	Aminotransferase
GOM46_RS02315	COG0017	Asparaginyl-tRNA synthetase
GOM46_RS02340	COG3231	kanamycin kinase activity
GOM46_RS02345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GOM46_RS02350	COG0149	triose-phosphate isomerase activity
GOM46_RS02370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GOM46_RS02390	COG0251	oxidation-reduction process
GOM46_RS02400	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GOM46_RS02410	COG0492	ferredoxin-NADP+ reductase activity
GOM46_RS02435	COG1307	EDD domain protein, DegV family
GOM46_RS02445	COG0617	tRNA 3'-terminal CCA addition
GOM46_RS02450	COG0488	(ABC) transporter
GOM46_RS02460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GOM46_RS02470	COG3935	DnaD domain protein
GOM46_RS02480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GOM46_RS02505	COG0287	Prephenate dehydrogenase
GOM46_RS02510	COG3679	Belongs to the UPF0342 family
GOM46_RS02520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GOM46_RS02525	COG0077	Prephenate dehydratase
GOM46_RS02535	COG3475	LICD family
GOM46_RS02545	COG1215	transferase activity, transferring glycosyl groups
GOM46_RS02565	COG3475	LICD family
GOM46_RS02570	COG3475	LICD family
GOM46_RS02585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GOM46_RS02590	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GOM46_RS02590	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GOM46_RS02595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GOM46_RS02610	COG1940	carbohydrate kinase activity
GOM46_RS02630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GOM46_RS02635	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GOM46_RS02645	COG0300	oxidoreductase activity
GOM46_RS02660	COG3250	beta-galactosidase activity
GOM46_RS02675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GOM46_RS02690	COG1304	FMN binding
GOM46_RS02695	COG3682	Transcriptional regulator
GOM46_RS02705	COG2217	Heavy metal translocating P-type atpase
GOM46_RS02710	COG0028	Belongs to the TPP enzyme family
GOM46_RS02725	COG1482	cell wall glycoprotein biosynthetic process
GOM46_RS02730	COG0733	neurotransmitter:sodium symporter activity
GOM46_RS02735	COG0789	Transcriptional regulator
GOM46_RS02740	COG2081	HI0933 family
GOM46_RS02745	COG1307	EDD domain protein, DegV family
GOM46_RS02755	COG2131	deaminase
GOM46_RS02760	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GOM46_RS02765	COG0740	serine-type endopeptidase activity
GOM46_RS02800	COG0517	IMP dehydrogenase activity
GOM46_RS02805	COG0360	Binds together with S18 to 16S ribosomal RNA
GOM46_RS02810	COG0629	single-stranded DNA binding
GOM46_RS02815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GOM46_RS02830	COG1098	S1 RNA binding domain
GOM46_RS02835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GOM46_RS02840	COG2827	Endonuclease containing a URI domain
GOM46_RS02860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GOM46_RS02865	COG2244	polysaccharide biosynthetic process
GOM46_RS02870	COG4166	transmembrane transport
GOM46_RS02875	COG0626	cystathionine gamma-synthase activity
GOM46_RS02880	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GOM46_RS02885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GOM46_RS02910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GOM46_RS02920	COG1113	amino acid transport
GOM46_RS02945	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GOM46_RS02960	COG0006	proline dipeptidase activity
GOM46_RS02965	COG3442	glutamine amidotransferase
GOM46_RS02970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GOM46_RS02975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GOM46_RS02980	COG0513	Belongs to the DEAD box helicase family
GOM46_RS02985	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GOM46_RS02990	COG1335	isochorismatase
GOM46_RS03000	COG0577	efflux transmembrane transporter activity
GOM46_RS03005	COG1136	(ABC) transporter
GOM46_RS03010	COG0577	efflux transmembrane transporter activity
GOM46_RS03015	COG0745	RESPONSE REGULATOR receiver
GOM46_RS03020	COG5002	protein histidine kinase activity
GOM46_RS03025	COG0191	fructose-bisphosphate aldolase activity
GOM46_RS03040	COG0596	Alpha beta hydrolase
GOM46_RS03045	COG4555	ABC transporter
GOM46_RS03075	COG0860	N-Acetylmuramoyl-L-alanine amidase
GOM46_RS03085	COG1301	dicarboxylic acid transport
GOM46_RS03100	COG0025	NhaP-type Na H and K H
GOM46_RS03110	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GOM46_RS03115	COG1242	4 iron, 4 sulfur cluster binding
GOM46_RS03120	COG2190	(PTS) system
GOM46_RS03120	COG1263	PTS System
GOM46_RS03120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GOM46_RS03135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GOM46_RS03140	COG0697	spore germination
GOM46_RS03155	COG1704	LemA family
GOM46_RS03165	COG0488	(ABC) transporter
GOM46_RS03180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GOM46_RS03195	COG0505	Belongs to the CarA family
GOM46_RS03225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GOM46_RS03255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GOM46_RS03265	COG0647	UMP catabolic process
GOM46_RS03275	COG1393	Belongs to the ArsC family
GOM46_RS03285	COG0483	inositol monophosphate 1-phosphatase activity
GOM46_RS03290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GOM46_RS03290	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
GOM46_RS03295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GOM46_RS03300	COG0573	inorganic phosphate transmembrane transporter activity
GOM46_RS03305	COG0581	inorganic phosphate transmembrane transporter activity
GOM46_RS03310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GOM46_RS03315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GOM46_RS03320	COG0704	Plays a role in the regulation of phosphate uptake
GOM46_RS03325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GOM46_RS03330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GOM46_RS03335	COG3527	Alpha-acetolactate decarboxylase
GOM46_RS03350	COG3842	ATPase activity
GOM46_RS03355	COG1177	transmembrane transport
GOM46_RS03385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GOM46_RS03390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GOM46_RS03395	COG0167	dihydroorotate dehydrogenase activity
GOM46_RS03405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GOM46_RS03410	COG0583	DNA-binding transcription factor activity
GOM46_RS03415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GOM46_RS03420	COG0564	pseudouridine synthase activity
GOM46_RS03425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GOM46_RS03445	COG1196	nuclear chromosome segregation
GOM46_RS03450	COG2860	membrane
GOM46_RS03460	COG0561	phosphatase activity
GOM46_RS03465	COG0561	phosphatase activity
GOM46_RS03470	COG0552	protein localization to endoplasmic reticulum
GOM46_RS03475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GOM46_RS03480	COG1126	abc transporter atp-binding protein
GOM46_RS03485	COG0765	amino acid transport
GOM46_RS03515	COG1827	regulation of RNA biosynthetic process
GOM46_RS03525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GOM46_RS03530	COG0222	ribosome binding
GOM46_RS03570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GOM46_RS03575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GOM46_RS03585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GOM46_RS03595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GOM46_RS03600	COG0237	dephospho-CoA kinase activity
GOM46_RS03605	COG2814	Major facilitator Superfamily
GOM46_RS03610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GOM46_RS03620	COG0557	exoribonuclease II activity
GOM46_RS03630	COG3615	Tellurite resistance protein tehB
GOM46_RS03630	COG0500	methyltransferase
GOM46_RS03650	COG4122	O-methyltransferase activity
GOM46_RS03660	COG0772	Belongs to the SEDS family
GOM46_RS03665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
GOM46_RS03680	COG3842	ATPase activity
GOM46_RS03685	COG0358	DNA primase activity
GOM46_RS03690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GOM46_RS03695	COG2151	metal-sulfur cluster biosynthetic enzyme
GOM46_RS03700	COG0438	transferase activity, transferring glycosyl groups
GOM46_RS03705	COG0438	transferase activity, transferring glycosyl groups
GOM46_RS03730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GOM46_RS03745	COG1194	a g-specific adenine glycosylase
GOM46_RS03750	COG0745	RESPONSE REGULATOR receiver
GOM46_RS03760	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GOM46_RS03770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GOM46_RS03775	COG0488	(ABC) transporter
GOM46_RS03785	COG1970	mechanosensitive ion channel activity
GOM46_RS03795	COG4708	membrane
GOM46_RS03830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GOM46_RS03845	COG0584	glycerophosphoryl diester phosphodiesterase
GOM46_RS03860	COG1063	alcohol dehydrogenase
GOM46_RS03875	COG4750	Nucleotidyl transferase
GOM46_RS03880	COG0543	2 iron, 2 sulfur cluster binding
GOM46_RS03885	COG0167	dihydroorotate dehydrogenase activity
GOM46_RS03890	COG0196	riboflavin kinase activity
GOM46_RS03910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GOM46_RS03915	COG1942	4-Oxalocrotonate Tautomerase
GOM46_RS03920	COG1435	thymidine kinase activity
GOM46_RS03930	COG2890	protein-(glutamine-N5) methyltransferase activity
GOM46_RS03955	COG0741	lytic transglycosylase activity
GOM46_RS03965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GOM46_RS03995	COG0488	(ABC) transporter
GOM46_RS04085	COG1597	lipid kinase activity
GOM46_RS04125	COG1982	Orn Lys Arg decarboxylase major
GOM46_RS04130	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GOM46_RS04150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GOM46_RS04160	COG3689	TIGRFAM TIGR03943 family protein
GOM46_RS04165	COG0701	Predicted permease
GOM46_RS04170	COG2183	response to ionizing radiation
GOM46_RS04185	COG1136	(ABC) transporter
GOM46_RS04190	COG0577	efflux transmembrane transporter activity
GOM46_RS04200	COG2873	o-acetylhomoserine
GOM46_RS04215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GOM46_RS04220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GOM46_RS04235	COG1104	cysteine desulfurase activity
GOM46_RS04240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GOM46_RS04250	COG2357	RelA SpoT domain protein
GOM46_RS04260	COG0564	pseudouridine synthase activity
GOM46_RS04265	COG0280	phosphate acetyltransferase
GOM46_RS04270	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GOM46_RS04315	COG0095	Lipoate-protein ligase
GOM46_RS04320	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GOM46_RS04325	COG0508	dehydrogenase complex catalyzes the overall conversion of
GOM46_RS04330	COG0022	dehydrogenase e1 component
GOM46_RS04335	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GOM46_RS04340	COG0534	Mate efflux family protein
GOM46_RS04345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GOM46_RS04350	COG1051	belongs to the nudix hydrolase family
GOM46_RS04370	COG1011	Hydrolase
GOM46_RS04375	COG1388	LysM domain
GOM46_RS04375	COG4932	domain protein
GOM46_RS04380	COG5263	repeat protein
GOM46_RS04380	COG4193	domain, Protein
GOM46_RS04425	COG0561	phosphatase activity
GOM46_RS04440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GOM46_RS04450	COG0494	nUDIX hydrolase
GOM46_RS04455	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GOM46_RS04470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GOM46_RS04490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GOM46_RS04495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GOM46_RS04500	COG4684	Psort location CytoplasmicMembrane, score
GOM46_RS04515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GOM46_RS04520	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GOM46_RS04530	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GOM46_RS04540	COG2723	6-phospho-beta-galactosidase activity
GOM46_RS04555	COG3711	transcriptional antiterminator
GOM46_RS04560	COG3684	Belongs to the aldolase LacD family
GOM46_RS04585	COG3775	system Galactitol-specific IIC component
GOM46_RS04615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GOM46_RS04620	COG0497	DNA recombination
GOM46_RS04625	COG1438	arginine binding
GOM46_RS04630	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GOM46_RS04665	COG0560	Phosphoserine phosphatase
GOM46_RS04675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GOM46_RS04685	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GOM46_RS04690	COG1523	belongs to the glycosyl hydrolase 13 family
GOM46_RS04700	COG2233	PERMEase
GOM46_RS04720	COG0066	3-isopropylmalate dehydratase activity
GOM46_RS04735	COG0473	3-isopropylmalate dehydrogenase activity
GOM46_RS04750	COG3142	Participates in the control of copper homeostasis
GOM46_RS04755	COG2832	Protein of unknown function (DUF454)
GOM46_RS04760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GOM46_RS04765	COG0758	DNA mediated transformation
GOM46_RS04775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GOM46_RS04780	COG3764	Sortase (surface protein transpeptidase)
GOM46_RS04785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GOM46_RS04790	COG0039	L-malate dehydrogenase activity
GOM46_RS04795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GOM46_RS04800	COG0785	Cytochrome C biogenesis protein
GOM46_RS04805	COG0024	Methionine aminopeptidase
GOM46_RS04810	COG4109	DRTGG domain
GOM46_RS04820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GOM46_RS04845	COG0673	inositol 2-dehydrogenase activity
GOM46_RS04860	COG1078	dGTPase activity
GOM46_RS04905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GOM46_RS04910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GOM46_RS04920	COG0716	FMN binding
GOM46_RS04925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GOM46_RS04975	COG0582	viral genome integration into host DNA
GOM46_RS04985	COG1307	EDD domain protein, DegV family
GOM46_RS04995	COG0628	permease
GOM46_RS05000	COG2706	6-phosphogluconolactonase activity
GOM46_RS05035	COG0356	it plays a direct role in the translocation of protons across the membrane
GOM46_RS05050	COG0826	peptidase U32
GOM46_RS05060	COG1596	polysaccharide export
GOM46_RS05060	COG1555	photosystem II stabilization
GOM46_RS05065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GOM46_RS05070	COG0686	Belongs to the AlaDH PNT family
GOM46_RS05075	COG1702	phosphate starvation-inducible protein PhoH
GOM46_RS05085	COG2996	Protein conserved in bacteria
GOM46_RS05095	COG0528	UMP kinase activity
GOM46_RS05120	COG0470	DNA polymerase III
GOM46_RS05135	COG0628	permease
GOM46_RS05140	COG1686	Belongs to the peptidase S11 family
GOM46_RS05145	COG0531	amino acid
GOM46_RS05155	COG0719	Fe-S assembly protein
GOM46_RS05165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GOM46_RS05170	COG0719	Fe-S assembly protein
GOM46_RS05185	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GOM46_RS05190	COG1956	GAF domain-containing protein
GOM46_RS05195	COG0539	negative regulation of cytoplasmic translation
GOM46_RS05230	COG4166	transmembrane transport
GOM46_RS05235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GOM46_RS05240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GOM46_RS05255	COG0187	DNA topoisomerase II activity
GOM46_RS05265	COG1126	abc transporter atp-binding protein
GOM46_RS05270	COG0765	amino acid transport
GOM46_RS05280	COG1079	Belongs to the binding-protein-dependent transport system permease family
GOM46_RS05285	COG4603	Belongs to the binding-protein-dependent transport system permease family
GOM46_RS05290	COG3845	ABC transporter
GOM46_RS05295	COG1744	ABC transporter substrate-binding protein PnrA-like
GOM46_RS05300	COG0295	cytidine deaminase activity
GOM46_RS05310	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GOM46_RS05315	COG2813	Specifically methylates the guanine in position
GOM46_RS05345	COG0813	purine-nucleoside phosphorylase activity
GOM46_RS05355	COG0038	chloride channel
GOM46_RS05360	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GOM46_RS05385	COG1136	(ABC) transporter
GOM46_RS05400	COG5002	protein histidine kinase activity
GOM46_RS05405	COG0745	RESPONSE REGULATOR receiver
GOM46_RS05435	COG1028	Short-chain dehydrogenase reductase Sdr
GOM46_RS05455	COG4989	oxidoreductase activity
GOM46_RS05460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GOM46_RS05460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GOM46_RS05465	COG0577	efflux transmembrane transporter activity
GOM46_RS05470	COG1136	(ABC) transporter
GOM46_RS05475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GOM46_RS05480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GOM46_RS05485	COG1268	BioY protein
GOM46_RS05490	COG4443	Transcriptional Coactivator p15 (PC4)
GOM46_RS05500	COG1328	CTP reductase activity
GOM46_RS05500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GOM46_RS05545	COG1349	DNA-binding transcription factor activity
GOM46_RS05550	COG0561	phosphatase activity
GOM46_RS05575	COG0488	(ABC) transporter
GOM46_RS05585	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GOM46_RS05590	COG4470	Protein conserved in bacteria
GOM46_RS05595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GOM46_RS05610	COG2382	esterase
GOM46_RS05620	COG1104	cysteine desulfurase activity
GOM46_RS05625	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GOM46_RS05630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GOM46_RS05635	COG0517	IMP dehydrogenase activity
GOM46_RS05640	COG0574	Belongs to the PEP-utilizing enzyme family
GOM46_RS05640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GOM46_RS05650	COG0697	spore germination
GOM46_RS05650	COG1674	ftsk spoiiie
GOM46_RS05655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GOM46_RS05655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GOM46_RS05655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GOM46_RS05660	COG1105	Belongs to the carbohydrate kinase PfkB family
GOM46_RS05675	COG1914	H( )-stimulated, divalent metal cation uptake system
GOM46_RS05690	COG0561	phosphatase activity
GOM46_RS05710	COG0492	ferredoxin-NADP+ reductase activity
GOM46_RS05720	COG1126	abc transporter atp-binding protein
GOM46_RS05730	COG1393	Belongs to the ArsC family
GOM46_RS05735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GOM46_RS05750	COG1272	protein, Hemolysin III
GOM46_RS05755	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GOM46_RS05770	COG2824	Alkylphosphonate utilization operon protein PhnA
GOM46_RS05790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GOM46_RS05795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GOM46_RS05800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GOM46_RS05805	COG2384	SAM-dependent methyltransferase
GOM46_RS05810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GOM46_RS05815	COG0204	Acyl-transferase
GOM46_RS05825	COG0469	pyruvate kinase activity
GOM46_RS05855	COG0443	Heat shock 70 kDa protein
GOM46_RS05865	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GOM46_RS05875	COG0726	polysaccharide deacetylase
GOM46_RS05885	COG0187	DNA topoisomerase II activity
GOM46_RS05895	COG0693	protein deglycase activity
GOM46_RS05900	COG0772	Belongs to the SEDS family
GOM46_RS05905	COG1199	ATP-dependent helicase activity
GOM46_RS05905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GOM46_RS05915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GOM46_RS05920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GOM46_RS05925	COG1126	abc transporter atp-binding protein
GOM46_RS05930	COG0765	amino acid transport
GOM46_RS05935	COG4703	Protein of unknown function (DUF1797)
GOM46_RS05940	COG0542	response to heat
GOM46_RS05945	COG0494	nUDIX hydrolase
GOM46_RS05965	COG2188	Transcriptional regulator
GOM46_RS05975	COG0513	Belongs to the DEAD box helicase family
GOM46_RS05980	COG2819	hydrolase of the alpha beta superfamily
GOM46_RS05995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GOM46_RS06010	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GOM46_RS06025	COG0745	RESPONSE REGULATOR receiver
GOM46_RS06040	COG3590	peptidase
GOM46_RS06060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GOM46_RS06080	COG3842	ATPase activity
GOM46_RS06090	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GOM46_RS06095	COG0215	cysteine-tRNA ligase activity
GOM46_RS06105	COG1045	serine acetyltransferase
GOM46_RS06120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GOM46_RS06125	COG3620	sequence-specific DNA binding
GOM46_RS06165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GOM46_RS06185	COG2177	Part of the ABC transporter FtsEX involved in
GOM46_RS06190	COG2884	Cell division ATP-binding protein ftsE
GOM46_RS06200	COG0402	S-adenosylhomocysteine deaminase activity
GOM46_RS06215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GOM46_RS06215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GOM46_RS06235	COG0242	peptide deformylase activity
GOM46_RS06245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GOM46_RS06250	COG1940	carbohydrate kinase activity
GOM46_RS06255	COG2190	(PTS) system
GOM46_RS06255	COG1263	PTS System
GOM46_RS06255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GOM46_RS06260	COG1621	beta-fructofuranosidase activity
GOM46_RS06265	COG1609	Transcriptional regulator
GOM46_RS06275	COG3425	synthase
GOM46_RS06290	COG0515	serine threonine protein kinase
GOM46_RS06290	COG2815	serine threonine protein kinase
GOM46_RS06295	COG0631	protein serine/threonine phosphatase activity
GOM46_RS06300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GOM46_RS06300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GOM46_RS06310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GOM46_RS06315	COG1758	RNA polymerase activity
GOM46_RS06320	COG0194	GDP metabolic process
GOM46_RS06330	COG1323	Belongs to the UPF0348 family
GOM46_RS06335	COG2226	methyltransferase
GOM46_RS06340	COG0799	negative regulation of ribosome biogenesis
GOM46_RS06345	COG1713	HD superfamily hydrolase involved in NAD metabolism
GOM46_RS06350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GOM46_RS06355	COG1534	Rna-binding protein
GOM46_RS06360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GOM46_RS06365	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GOM46_RS06375	COG0668	transmembrane transport
GOM46_RS06390	COG1217	gtp-binding protein TYPA
GOM46_RS06395	COG1187	pseudouridine synthase activity
GOM46_RS06425	COG4720	Psort location CytoplasmicMembrane, score
GOM46_RS06430	COG0351	phosphomethylpyrimidine kinase
GOM46_RS06445	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GOM46_RS06450	COG0159	tryptophan synthase activity
GOM46_RS06475	COG0512	Glutamine amidotransferase of anthranilate synthase
GOM46_RS06480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GOM46_RS06485	COG0133	tryptophan synthase activity
GOM46_RS06490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GOM46_RS06495	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GOM46_RS06500	COG1132	(ABC) transporter
GOM46_RS06505	COG1132	(ABC) transporter
GOM46_RS06510	COG0708	Exodeoxyribonuclease III
GOM46_RS06525	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GOM46_RS06530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GOM46_RS06535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GOM46_RS06540	COG1609	Transcriptional regulator
GOM46_RS06545	COG1063	alcohol dehydrogenase
GOM46_RS06550	COG0656	L-ascorbic acid biosynthetic process
GOM46_RS06555	COG1230	cation diffusion facilitator family transporter
GOM46_RS06665	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GOM46_RS06670	COG0588	phosphoglycerate mutase activity
GOM46_RS06680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GOM46_RS06685	COG3599	regulation of cell shape
GOM46_RS06690	COG3599	regulation of cell shape
GOM46_RS06710	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GOM46_RS06715	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GOM46_RS06725	COG0438	transferase activity, transferring glycosyl groups
GOM46_RS06730	COG0562	UDP-galactopyranose mutase
GOM46_RS06745	COG1442	glycosyl transferase family 8
GOM46_RS06745	COG1216	Glycosyl transferase, family 2
GOM46_RS06750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GOM46_RS06755	COG0438	transferase activity, transferring glycosyl groups
GOM46_RS06765	COG3475	LICD family
GOM46_RS06775	COG0489	protein tyrosine kinase activity
GOM46_RS06780	COG3944	biosynthesis protein
GOM46_RS06785	COG4464	protein tyrosine phosphatase activity
GOM46_RS06795	COG4166	transmembrane transport
GOM46_RS06800	COG4166	transmembrane transport
GOM46_RS06805	COG0366	Alpha amylase catalytic
GOM46_RS06855	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GOM46_RS06870	COG2918	glutathione biosynthetic process
GOM46_RS06870	COG1181	Belongs to the D-alanine--D-alanine ligase family
GOM46_RS06895	COG0464	growth
GOM46_RS06900	COG0561	phosphatase activity
GOM46_RS06960	COG0515	serine threonine protein kinase
GOM46_RS06990	COG1476	TRANSCRIPTIONal
GOM46_RS07005	COG1674	ftsk spoiiie
GOM46_RS07055	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GOM46_RS07060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GOM46_RS07070	COG1051	belongs to the nudix hydrolase family
GOM46_RS07075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GOM46_RS07090	COG0768	penicillin binding
GOM46_RS07110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GOM46_RS07120	COG2731	YhcH YjgK YiaL family protein
GOM46_RS07125	COG0395	ABC-type sugar transport system, permease component
GOM46_RS07130	COG1175	transmembrane transport
GOM46_RS07150	COG3458	cephalosporin-C deacetylase activity
GOM46_RS07160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GOM46_RS07175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GOM46_RS07180	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
GOM46_RS07210	COG1484	DNA-dependent DNA replication
GOM46_RS07225	COG1725	Transcriptional regulator
GOM46_RS07230	COG1131	(ABC) transporter
GOM46_RS07240	COG1346	cytolysis
GOM46_RS07260	COG3118	belongs to the thioredoxin family
GOM46_RS07265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GOM46_RS07275	COG1164	Oligoendopeptidase f
GOM46_RS07280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GOM46_RS07285	COG2264	protein methyltransferase activity
GOM46_RS07295	COG1051	belongs to the nudix hydrolase family
GOM46_RS07305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GOM46_RS07335	COG0628	permease
GOM46_RS07375	COG2309	aminopeptidase activity
GOM46_RS07385	COG2176	DNA-directed DNA polymerase activity
GOM46_RS07415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GOM46_RS07455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GOM46_RS07470	COG2151	metal-sulfur cluster biosynthetic enzyme
GOM46_RS07490	COG3759	membrane
GOM46_RS07515	COG0534	Mate efflux family protein
GOM46_RS07535	COG3715	PTS system
GOM46_RS07540	COG3716	PTS system mannose fructose sorbose family IID component
GOM46_RS07545	COG3579	cysteine-type endopeptidase activity
GOM46_RS07550	COG1187	pseudouridine synthase activity
GOM46_RS07565	COG2849	repeat protein
GOM46_RS07575	COG2255	four-way junction helicase activity
GOM46_RS07595	COG2972	Histidine kinase
GOM46_RS07600	COG4753	response regulator
GOM46_RS07600	COG2207	Transcriptional regulator
GOM46_RS07605	COG1840	ABC-type Fe3 transport system, periplasmic component
GOM46_RS07610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GOM46_RS07615	COG3842	ATPase activity
GOM46_RS07620	COG1178	ABC-type Fe3 transport system permease component
GOM46_RS07630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GOM46_RS07635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GOM46_RS07640	COG0697	spore germination
GOM46_RS07655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GOM46_RS07665	COG2723	6-phospho-beta-galactosidase activity
GOM46_RS07675	COG0750	zinc metalloprotease
GOM46_RS07680	COG4589	Belongs to the CDS family
GOM46_RS07685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GOM46_RS07700	COG0519	Catalyzes the synthesis of GMP from XMP
GOM46_RS07705	COG0525	valine-tRNA ligase activity
GOM46_RS07710	COG2197	response regulator
GOM46_RS07715	COG4585	Histidine kinase
GOM46_RS07720	COG0842	Transport permease protein
GOM46_RS07725	COG1131	(ABC) transporter
GOM46_RS07740	COG1461	Dihydroxyacetone kinase
GOM46_RS07750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GOM46_RS07790	COG0217	transcriptional regulatory protein
GOM46_RS07795	COG0534	Mate efflux family protein
GOM46_RS07815	COG1316	TRANSCRIPTIONal
GOM46_RS07825	COG0802	atpase or kinase
GOM46_RS07830	COG2252	PERMEase
GOM46_RS07835	COG0561	phosphatase activity
GOM46_RS07845	COG0285	dihydrofolate synthase activity
GOM46_RS07870	COG1393	Belongs to the ArsC family
GOM46_RS07880	COG0006	proline dipeptidase activity
GOM46_RS07885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GOM46_RS07910	COG0519	Catalyzes the synthesis of GMP from XMP
GOM46_RS07930	COG2226	methyltransferase
GOM46_RS07935	COG0058	SHG alpha-glucan phosphorylase activity
GOM46_RS07940	COG1640	4-alpha-glucanotransferase
GOM46_RS07945	COG2182	Extracellular solute-binding protein
GOM46_RS07950	COG1175	transmembrane transport
GOM46_RS07985	COG4932	domain protein
GOM46_RS07990	COG0124	histidyl-tRNA synthetase
GOM46_RS08005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GOM46_RS08010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GOM46_RS08015	COG1464	Belongs to the NlpA lipoprotein family
GOM46_RS08020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GOM46_RS08050	COG1214	PFAM Peptidase M22, glycoprotease
GOM46_RS08075	COG2222	sugar isomerase
GOM46_RS08085	COG3716	PTS system mannose fructose sorbose family IID component
GOM46_RS08090	COG3715	PTS system
GOM46_RS08095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GOM46_RS08125	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GOM46_RS08140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GOM46_RS08145	COG0151	Belongs to the GarS family
GOM46_RS08155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GOM46_RS08165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GOM46_RS08170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GOM46_RS08180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GOM46_RS08190	COG2348	transferase activity, transferring amino-acyl groups
GOM46_RS08195	COG3942	CHAP domain
GOM46_RS08205	COG1792	Involved in formation and maintenance of cell shape
GOM46_RS08210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GOM46_RS08215	COG1122	ATPase activity
GOM46_RS08220	COG1122	ATPase activity
GOM46_RS08225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GOM46_RS08235	COG0612	Peptidase, M16
GOM46_RS08240	COG0612	Peptidase, M16
GOM46_RS08245	COG2501	S4 domain
GOM46_RS08255	COG0516	GMP reductase activity
GOM46_RS08255	COG0517	IMP dehydrogenase activity
GOM46_RS08260	COG0180	Tryptophanyl-tRNA synthetase
GOM46_RS08265	COG0488	(ABC) transporter
GOM46_RS08270	COG1511	domain protein
GOM46_RS08270	COG1511	domain protein
GOM46_RS08310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GOM46_RS08315	COG1475	DNA binding