locus-tag	class	description
D5R92_RS00010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5R92_RS00015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5R92_RS00020	COG1328	CTP reductase activity
D5R92_RS00020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5R92_RS00025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5R92_RS00030	COG0488	(ABC) transporter
D5R92_RS00055	COG1272	protein, Hemolysin III
D5R92_RS00075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D5R92_RS00085	COG0110	maltose O-acetyltransferase activity
D5R92_RS00090	COG0758	DNA mediated transformation
D5R92_RS00095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5R92_RS00100	COG0583	DNA-binding transcription factor activity
D5R92_RS00125	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D5R92_RS00135	COG3328	transposase activity
D5R92_RS00140	COG1136	(ABC) transporter
D5R92_RS00145	COG0577	efflux transmembrane transporter activity
D5R92_RS00150	COG0745	RESPONSE REGULATOR receiver
D5R92_RS00165	COG4974	Belongs to the 'phage' integrase family
D5R92_RS00180	COG3328	transposase activity
D5R92_RS00185	COG0515	serine threonine protein kinase
D5R92_RS00185	COG2815	serine threonine protein kinase
D5R92_RS00195	COG3328	transposase activity
D5R92_RS00215	COG0662	Cupin 2, conserved barrel domain protein
D5R92_RS00220	COG0673	inositol 2-dehydrogenase activity
D5R92_RS00235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5R92_RS00240	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D5R92_RS00245	COG2188	Transcriptional regulator
D5R92_RS00275	COG3104	oligopeptide transport
D5R92_RS00280	COG0386	Belongs to the glutathione peroxidase family
D5R92_RS00300	COG3328	transposase activity
D5R92_RS00310	COG0346	lactoylglutathione lyase activity
D5R92_RS00315	COG3764	Sortase (surface protein transpeptidase)
D5R92_RS00325	COG0039	L-malate dehydrogenase activity
D5R92_RS00345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5R92_RS00350	COG3153	acetyltransferase
D5R92_RS00355	COG0009	L-threonylcarbamoyladenylate synthase
D5R92_RS00360	COG2890	protein-(glutamine-N5) methyltransferase activity
D5R92_RS00365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5R92_RS00400	COG2801	Transposase and inactivated derivatives
D5R92_RS00405	COG2233	PERMEase
D5R92_RS00415	COG0516	GMP reductase activity
D5R92_RS00420	COG1174	glycine betaine transport
D5R92_RS00425	COG1125	glycine betaine transport
D5R92_RS00425	COG0517	IMP dehydrogenase activity
D5R92_RS00440	COG4221	oxidoreductase activity
D5R92_RS00445	COG0280	phosphate acetyltransferase
D5R92_RS00450	COG0564	pseudouridine synthase activity
D5R92_RS00460	COG2357	RelA SpoT domain protein
D5R92_RS00475	COG1104	cysteine desulfurase activity
D5R92_RS00495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D5R92_RS00500	COG2003	Belongs to the UPF0758 family
D5R92_RS00505	COG0628	permease
D5R92_RS00510	COG2723	6-phospho-beta-galactosidase activity
D5R92_RS00525	COG2723	6-phospho-beta-galactosidase activity
D5R92_RS00530	COG2207	Transcriptional regulator
D5R92_RS00535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5R92_RS00535	COG2190	(PTS) system
D5R92_RS00535	COG1263	PTS System
D5R92_RS00560	COG3493	citrate carrier protein
D5R92_RS00565	COG3290	protein histidine kinase activity
D5R92_RS00570	COG4565	transcriptional regulatory protein
D5R92_RS00580	COG1177	transmembrane transport
D5R92_RS00585	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5R92_RS00595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D5R92_RS00600	COG2826	transposase and inactivated derivatives, IS30 family
D5R92_RS00605	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5R92_RS00620	COG0302	gtp cyclohydrolase
D5R92_RS00625	COG0285	dihydrofolate synthase activity
D5R92_RS00630	COG0083	homoserine kinase activity
D5R92_RS00645	COG3328	transposase activity
D5R92_RS00705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D5R92_RS00715	COG3425	synthase
D5R92_RS00725	COG1304	FMN binding
D5R92_RS00740	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D5R92_RS00745	COG1132	(ABC) transporter
D5R92_RS00750	COG1132	(ABC) transporter
D5R92_RS00760	COG0242	peptide deformylase activity
D5R92_RS00765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5R92_RS00770	COG1132	(ABC) transporter
D5R92_RS00785	COG0488	(ABC) transporter
D5R92_RS00790	COG0617	tRNA 3'-terminal CCA addition
D5R92_RS00795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5R92_RS00820	COG1705	Flagellar rod assembly protein muramidase FlgJ
D5R92_RS00820	COG1388	LysM domain
D5R92_RS00825	COG1388	LysM domain
D5R92_RS00825	COG1705	Flagellar rod assembly protein muramidase FlgJ
D5R92_RS00830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5R92_RS00830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5R92_RS00830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5R92_RS00835	COG1105	Belongs to the carbohydrate kinase PfkB family
D5R92_RS00840	COG1349	DNA-binding transcription factor activity
D5R92_RS00860	COG0336	Belongs to the RNA methyltransferase TrmD family
D5R92_RS00865	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5R92_RS00875	COG1837	Belongs to the UPF0109 family
D5R92_RS00880	COG0228	four-way junction DNA binding
D5R92_RS00890	COG0577	efflux transmembrane transporter activity
D5R92_RS00895	COG1136	(ABC) transporter
D5R92_RS00910	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D5R92_RS00915	COG0564	pseudouridine synthase activity
D5R92_RS00925	COG0583	DNA-binding transcription factor activity
D5R92_RS00930	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D5R92_RS00980	COG1104	cysteine desulfurase activity
D5R92_RS00990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5R92_RS01015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5R92_RS01020	COG1368	sulfuric ester hydrolase activity
D5R92_RS01030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D5R92_RS01040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5R92_RS01080	COG1216	Glycosyl transferase, family 2
D5R92_RS01080	COG1442	glycosyl transferase family 8
D5R92_RS01095	COG0463	Glycosyl transferase, family 2
D5R92_RS01130	COG0463	Glycosyl transferase, family 2
D5R92_RS01145	COG2151	metal-sulfur cluster biosynthetic enzyme
D5R92_RS01150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5R92_RS01155	COG0358	DNA primase activity
D5R92_RS01160	COG1970	mechanosensitive ion channel activity
D5R92_RS01170	COG1074	ATP-dependent DNA helicase activity
D5R92_RS01180	COG2321	neutral zinc metallopeptidase
D5R92_RS01185	COG1136	(ABC) transporter
D5R92_RS01190	COG0577	efflux transmembrane transporter activity
D5R92_RS01235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D5R92_RS01240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D5R92_RS01245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5R92_RS01265	COG0356	it plays a direct role in the translocation of protons across the membrane
D5R92_RS01275	COG0297	glycogen (starch) synthase activity
D5R92_RS01285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5R92_RS01295	COG1523	belongs to the glycosyl hydrolase 13 family
D5R92_RS01300	COG1597	lipid kinase activity
D5R92_RS01305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5R92_RS01310	COG4708	membrane
D5R92_RS01335	COG1131	(ABC) transporter
D5R92_RS01375	COG0148	phosphopyruvate hydratase activity
D5R92_RS01395	COG0560	Phosphoserine phosphatase
D5R92_RS01400	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D5R92_RS01415	COG0772	Belongs to the SEDS family
D5R92_RS01430	COG0335	large ribosomal subunit rRNA binding
D5R92_RS01435	COG0038	chloride channel
D5R92_RS01445	COG0716	FMN binding
D5R92_RS01455	COG0625	glutathione transferase activity
D5R92_RS01465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D5R92_RS01470	COG2153	protein acetylation
D5R92_RS01475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D5R92_RS01515	COG1660	Displays ATPase and GTPase activities
D5R92_RS01525	COG0017	Asparaginyl-tRNA synthetase
D5R92_RS01530	COG0436	Aminotransferase
D5R92_RS01535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5R92_RS01535	COG1199	ATP-dependent helicase activity
D5R92_RS01545	COG2177	Part of the ABC transporter FtsEX involved in
D5R92_RS01550	COG2884	Cell division ATP-binding protein ftsE
D5R92_RS01560	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D5R92_RS01565	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
D5R92_RS01575	COG0584	glycerophosphoryl diester phosphodiesterase
D5R92_RS01595	COG1078	dGTPase activity
D5R92_RS01630	COG1595	DNA-templated transcription, initiation
D5R92_RS01635	COG0772	Belongs to the SEDS family
D5R92_RS01645	COG1164	Oligoendopeptidase f
D5R92_RS01665	COG3859	Proton-coupled thiamine transporter YuaJ
D5R92_RS01670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D5R92_RS01675	COG3304	Inner membrane component domain
D5R92_RS01680	COG0406	alpha-ribazole phosphatase activity
D5R92_RS01720	COG0285	dihydrofolate synthase activity
D5R92_RS01725	COG2986	histidine ammonia-lyase
D5R92_RS01730	COG0531	amino acid
D5R92_RS01745	COG3404	Formiminotransferase-cyclodeaminase
D5R92_RS01760	COG1228	amidohydrolase
D5R92_RS01765	COG4166	transmembrane transport
D5R92_RS01770	COG4443	Transcriptional Coactivator p15 (PC4)
D5R92_RS01775	COG0826	peptidase U32
D5R92_RS01815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D5R92_RS01835	COG2183	response to ionizing radiation
D5R92_RS01845	COG0704	Plays a role in the regulation of phosphate uptake
D5R92_RS01850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5R92_RS01855	COG0581	inorganic phosphate transmembrane transporter activity
D5R92_RS01860	COG0573	inorganic phosphate transmembrane transporter activity
D5R92_RS01865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D5R92_RS01870	COG5002	protein histidine kinase activity
D5R92_RS01875	COG0745	RESPONSE REGULATOR receiver
D5R92_RS01880	COG0346	lactoylglutathione lyase activity
D5R92_RS01890	COG0701	Predicted permease
D5R92_RS01895	COG3689	TIGRFAM TIGR03943 family protein
D5R92_RS01900	COG1090	epimerase
D5R92_RS01905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5R92_RS01915	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5R92_RS01925	COG3711	transcriptional antiterminator
D5R92_RS01925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5R92_RS01935	COG2723	6-phospho-beta-galactosidase activity
D5R92_RS01945	COG0552	protein localization to endoplasmic reticulum
D5R92_RS01950	COG0561	phosphatase activity
D5R92_RS01955	COG0561	phosphatase activity
D5R92_RS01975	COG3328	transposase activity
D5R92_RS01990	COG1196	nuclear chromosome segregation
D5R92_RS01995	COG0571	ribonuclease III activity
D5R92_RS02000	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5R92_RS02005	COG5002	protein histidine kinase activity
D5R92_RS02010	COG0745	RESPONSE REGULATOR receiver
D5R92_RS02015	COG1126	abc transporter atp-binding protein
D5R92_RS02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5R92_RS02025	COG0765	amino acid transport
D5R92_RS02030	COG0765	amino acid transport
D5R92_RS02040	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5R92_RS02045	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D5R92_RS02050	COG1461	Dihydroxyacetone kinase
D5R92_RS02055	COG2376	Dihydroxyacetone kinase
D5R92_RS02065	COG2376	Dihydroxyacetone kinase
D5R92_RS02075	COG3328	transposase activity
D5R92_RS02080	COG4152	abc transporter atp-binding protein
D5R92_RS02095	COG1131	(ABC) transporter
D5R92_RS02105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5R92_RS02110	COG0438	transferase activity, transferring glycosyl groups
D5R92_RS02120	COG1609	Transcriptional regulator
D5R92_RS02125	COG0006	proline dipeptidase activity
D5R92_RS02135	COG0778	Nitroreductase
D5R92_RS02140	COG0346	lactoylglutathione lyase activity
D5R92_RS02145	COG0463	Glycosyl transferase, family 2
D5R92_RS02160	COG3328	transposase activity
D5R92_RS02180	COG0557	exoribonuclease II activity
D5R92_RS02195	COG0433	COG0433 Predicted ATPase
D5R92_RS02200	COG2364	Membrane
D5R92_RS02235	COG3328	transposase activity
D5R92_RS02270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5R92_RS02275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D5R92_RS02280	COG1573	uracil-dna glycosylase
D5R92_RS02285	COG1702	phosphate starvation-inducible protein PhoH
D5R92_RS02300	COG4479	Belongs to the UPF0346 family
D5R92_RS02305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5R92_RS02315	COG0233	cytoplasmic translational termination
D5R92_RS02325	COG0081	regulation of translation
D5R92_RS02330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D5R92_RS02335	COG2826	transposase and inactivated derivatives, IS30 family
D5R92_RS02375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5R92_RS02385	COG0494	nUDIX hydrolase
D5R92_RS02390	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D5R92_RS02395	COG0673	inositol 2-dehydrogenase activity
D5R92_RS02400	COG1028	Short-chain dehydrogenase reductase Sdr
D5R92_RS02430	COG1114	Component of the transport system for branched-chain amino acids
D5R92_RS02460	COG1304	FMN binding
D5R92_RS02465	COG1620	l-lactate permease
D5R92_RS02475	COG0640	Transcriptional regulator
D5R92_RS02480	COG0708	Exodeoxyribonuclease III
D5R92_RS02510	COG1393	Belongs to the ArsC family
D5R92_RS02515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5R92_RS02520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5R92_RS02530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D5R92_RS02550	COG1774	PSP1 C-terminal conserved region
D5R92_RS02555	COG0470	DNA polymerase III
D5R92_RS02560	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5R92_RS02565	COG0517	IMP dehydrogenase activity
D5R92_RS02585	COG0559	Belongs to the binding-protein-dependent transport system permease family
D5R92_RS02595	COG4471	UPF0298 protein
D5R92_RS02620	COG2244	polysaccharide biosynthetic process
D5R92_RS02640	COG1120	ATPase activity
D5R92_RS02645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5R92_RS02650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5R92_RS02655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5R92_RS02670	COG1227	inorganic diphosphatase activity
D5R92_RS02675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D5R92_RS02680	COG1253	flavin adenine dinucleotide binding
D5R92_RS02690	COG1605	Chorismate mutase
D5R92_RS02690	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D5R92_RS02705	COG1131	(ABC) transporter
D5R92_RS02710	COG1242	4 iron, 4 sulfur cluster binding
D5R92_RS02715	COG0671	phosphoesterase, PA-phosphatase related
D5R92_RS02720	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D5R92_RS02730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5R92_RS02735	COG1187	pseudouridine synthase activity
D5R92_RS02745	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D5R92_RS02770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D5R92_RS02775	COG3763	UPF0154 protein
D5R92_RS02795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5R92_RS02800	COG1254	Belongs to the acylphosphatase family
D5R92_RS02815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5R92_RS02860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5R92_RS02870	COG1484	DNA-dependent DNA replication
D5R92_RS02880	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5R92_RS02890	COG0745	RESPONSE REGULATOR receiver
D5R92_RS02900	COG0501	Belongs to the peptidase M48B family
D5R92_RS02905	COG1704	LemA family
D5R92_RS02915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5R92_RS02920	COG0569	domain protein
D5R92_RS02930	COG1114	Component of the transport system for branched-chain amino acids
D5R92_RS02945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5R92_RS02950	COG1464	Belongs to the NlpA lipoprotein family
D5R92_RS02955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5R92_RS02970	COG0789	Transcriptional regulator
D5R92_RS02985	COG2226	methyltransferase
D5R92_RS02990	COG0799	negative regulation of ribosome biogenesis
D5R92_RS02995	COG1713	HD superfamily hydrolase involved in NAD metabolism
D5R92_RS03005	COG1534	Rna-binding protein
D5R92_RS03010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D5R92_RS03015	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D5R92_RS03065	COG1040	competence protein
D5R92_RS03070	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D5R92_RS03075	COG1739	Uncharacterized protein family UPF0029
D5R92_RS03090	COG1098	S1 RNA binding domain
D5R92_RS03100	COG2197	response regulator
D5R92_RS03105	COG4585	Histidine kinase
D5R92_RS03115	COG2815	serine threonine protein kinase
D5R92_RS03115	COG0515	serine threonine protein kinase
D5R92_RS03125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5R92_RS03125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5R92_RS03135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5R92_RS03140	COG1758	RNA polymerase activity
D5R92_RS03155	COG1854	S-ribosylhomocysteine lyase activity
D5R92_RS03165	COG0116	Belongs to the methyltransferase superfamily
D5R92_RS03180	COG4474	Belongs to the UPF0398 family
D5R92_RS03185	COG3331	DNA recombination
D5R92_RS03190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5R92_RS03195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D5R92_RS03200	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D5R92_RS03215	COG1113	amino acid transport
D5R92_RS03220	COG0492	ferredoxin-NADP+ reductase activity
D5R92_RS03230	COG1126	abc transporter atp-binding protein
D5R92_RS03235	COG0765	amino acid transport
D5R92_RS03240	COG0513	Belongs to the DEAD box helicase family
D5R92_RS03245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5R92_RS03250	COG0768	penicillin binding
D5R92_RS03260	COG0275	rRNA processing
D5R92_RS03270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5R92_RS03280	COG1131	(ABC) transporter
D5R92_RS03300	COG0446	pyridine nucleotide-disulphide oxidoreductase
D5R92_RS03305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5R92_RS03330	COG0751	glycine-tRNA ligase activity
D5R92_RS03340	COG1755	Isoprenylcysteine carboxyl methyltransferase
D5R92_RS03345	COG0656	L-ascorbic acid biosynthetic process
D5R92_RS03360	COG0561	phosphatase activity
D5R92_RS03370	COG3250	beta-galactosidase activity
D5R92_RS03405	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D5R92_RS03410	COG0195	Participates in both transcription termination and antitermination
D5R92_RS03415	COG0779	Required for maturation of 30S ribosomal subunits
D5R92_RS03420	COG1368	sulfuric ester hydrolase activity
D5R92_RS03455	COG1131	(ABC) transporter
D5R92_RS03460	COG0537	adenosine 5'-monophosphoramidase activity
D5R92_RS03470	COG1316	TRANSCRIPTIONal
D5R92_RS03480	COG0802	atpase or kinase
D5R92_RS03485	COG2252	PERMEase
D5R92_RS03490	COG0561	phosphatase activity
D5R92_RS03505	COG3715	PTS system
D5R92_RS03510	COG3716	PTS system mannose fructose sorbose family IID component
D5R92_RS03525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D5R92_RS03545	COG0439	Biotin carboxylase
D5R92_RS03560	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5R92_RS03565	COG1028	Short-chain dehydrogenase reductase Sdr
D5R92_RS03570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5R92_RS03585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5R92_RS03595	COG1024	Enoyl-CoA hydratase
D5R92_RS03600	COG0484	heat shock protein binding
D5R92_RS03610	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5R92_RS03615	COG1420	regulation of RNA biosynthetic process
D5R92_RS03620	COG1705	Flagellar rod assembly protein muramidase FlgJ
D5R92_RS03620	COG1388	LysM domain
D5R92_RS03630	COG0588	phosphoglycerate mutase activity
D5R92_RS03635	COG2848	UPF0210 protein
D5R92_RS03640	COG3830	Belongs to the UPF0237 family
D5R92_RS03645	COG2261	transglycosylase associated protein
D5R92_RS03660	COG0154	amidase activity
D5R92_RS03665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5R92_RS03670	COG0574	Belongs to the PEP-utilizing enzyme family
D5R92_RS03670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5R92_RS03675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D5R92_RS03680	COG0517	IMP dehydrogenase activity
D5R92_RS03685	COG1054	Belongs to the UPF0176 family
D5R92_RS03700	COG1937	Protein conserved in bacteria
D5R92_RS03705	COG1335	isochorismatase
D5R92_RS03710	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D5R92_RS03715	COG0436	Aminotransferase
D5R92_RS03720	COG0589	response to stress
D5R92_RS03725	COG0561	phosphatase activity
D5R92_RS03730	COG3328	transposase activity
D5R92_RS03740	COG0252	asparaginase activity
D5R92_RS03745	COG4989	oxidoreductase activity
D5R92_RS03750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5R92_RS03755	COG1129	ABC transporter
D5R92_RS03770	COG1132	(ABC) transporter
D5R92_RS03775	COG4988	ABC transporter
D5R92_RS03780	COG1120	ATPase activity
D5R92_RS03805	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5R92_RS03810	COG0736	holo-[acyl-carrier-protein] synthase activity
D5R92_RS03815	COG0653	protein targeting
D5R92_RS03820	COG1482	cell wall glycoprotein biosynthetic process
D5R92_RS03825	COG1940	carbohydrate kinase activity
D5R92_RS03830	COG1263	PTS System
D5R92_RS03830	COG2190	(PTS) system
D5R92_RS03830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5R92_RS03835	COG1621	beta-fructofuranosidase activity
D5R92_RS03840	COG1609	Transcriptional regulator
D5R92_RS03845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5R92_RS03865	COG2131	deaminase
D5R92_RS03870	COG0006	proline dipeptidase activity
D5R92_RS03900	COG1368	sulfuric ester hydrolase activity
D5R92_RS03925	COG1194	a g-specific adenine glycosylase
D5R92_RS03935	COG3118	belongs to the thioredoxin family
D5R92_RS03940	COG1193	negative regulation of DNA recombination
D5R92_RS03955	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5R92_RS03960	COG0681	Belongs to the peptidase S26 family
D5R92_RS03965	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5R92_RS03980	COG1882	Formate acetyltransferase
D5R92_RS03995	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5R92_RS04010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5R92_RS04015	COG2936	dipeptidyl-peptidase activity
D5R92_RS04030	COG3942	CHAP domain
D5R92_RS04030	COG1705	Flagellar rod assembly protein muramidase FlgJ
D5R92_RS04175	COG3328	transposase activity
D5R92_RS04185	COG0515	serine threonine protein kinase
D5R92_RS04195	COG1476	TRANSCRIPTIONal
D5R92_RS04230	COG0582	viral genome integration into host DNA
D5R92_RS04260	COG2081	HI0933 family
D5R92_RS04280	COG1214	PFAM Peptidase M22, glycoprotease
D5R92_RS04290	COG5503	Protein of unknown function (DUF1447)
D5R92_RS04300	COG4608	Belongs to the ABC transporter superfamily
D5R92_RS04305	COG0444	Belongs to the ABC transporter superfamily
D5R92_RS04325	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D5R92_RS04360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5R92_RS04390	COG1288	antiporter activity
D5R92_RS04395	COG0549	Belongs to the carbamate kinase family
D5R92_RS04400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5R92_RS04410	COG0784	Response regulator, receiver
D5R92_RS04415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D5R92_RS04420	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D5R92_RS04425	COG0084	hydrolase, TatD family'
D5R92_RS04450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5R92_RS04465	COG0395	ABC-type sugar transport system, permease component
D5R92_RS04490	COG0395	ABC-type sugar transport system, permease component
D5R92_RS04495	COG1175	transmembrane transport
D5R92_RS04530	COG3279	Response regulator of the LytR AlgR family
D5R92_RS04540	COG1131	(ABC) transporter
D5R92_RS04555	COG0594	ribonuclease P activity
D5R92_RS04560	COG0165	Argininosuccinate lyase
D5R92_RS04620	COG0756	dUTP diphosphatase activity
D5R92_RS04625	COG1263	PTS System
D5R92_RS04625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5R92_RS04630	COG0366	Alpha amylase catalytic
D5R92_RS04640	COG1737	Transcriptional regulator
D5R92_RS04645	COG2832	Protein of unknown function (DUF454)
D5R92_RS04675	COG1132	(ABC) transporter
D5R92_RS04680	COG1132	(ABC) transporter
D5R92_RS04690	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D5R92_RS04695	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5R92_RS04710	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D5R92_RS04715	COG1215	transferase activity, transferring glycosyl groups
D5R92_RS04720	COG1473	amidohydrolase
D5R92_RS04730	COG0166	Belongs to the GPI family
D5R92_RS04780	COG1234	tRNA 3'-trailer cleavage
D5R92_RS04785	COG1268	BioY protein
D5R92_RS04800	COG0343	queuine tRNA-ribosyltransferase activity
D5R92_RS04810	COG0735	belongs to the Fur family
D5R92_RS04815	COG1832	CoA-binding protein
D5R92_RS04820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5R92_RS04820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5R92_RS04830	COG4175	Glycine betaine
D5R92_RS04830	COG3448	diguanylate cyclase activity
D5R92_RS04835	COG1597	lipid kinase activity
D5R92_RS04845	COG0415	Belongs to the DNA photolyase family
D5R92_RS04870	COG3775	system Galactitol-specific IIC component
D5R92_RS04875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5R92_RS04885	COG1609	Transcriptional regulator
D5R92_RS04895	COG3623	hexulose-6-phosphate isomerase
D5R92_RS04905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5R92_RS04920	COG1929	Belongs to the glycerate kinase type-1 family
D5R92_RS04930	COG2964	Protein conserved in bacteria
D5R92_RS04935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5R92_RS04940	COG0626	cystathionine gamma-synthase activity
D5R92_RS04945	COG0251	oxidation-reduction process
D5R92_RS04955	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D5R92_RS04980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5R92_RS04995	COG0564	pseudouridine synthase activity
D5R92_RS05015	COG0459	protein refolding
D5R92_RS05025	COG0542	response to heat
D5R92_RS05030	COG4463	regulation of RNA biosynthetic process
D5R92_RS05045	COG0025	NhaP-type Na H and K H
D5R92_RS05055	COG0450	alkyl hydroperoxide reductase
D5R92_RS05080	COG3590	peptidase
D5R92_RS05085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5R92_RS05090	COG3959	Transketolase, thiamine diphosphate binding domain
D5R92_RS05105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5R92_RS05110	COG0366	Alpha amylase catalytic
D5R92_RS05115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5R92_RS05115	COG1263	PTS System
D5R92_RS05120	COG2188	Transcriptional regulator
D5R92_RS05130	COG0602	queuosine metabolic process
D5R92_RS05140	COG0673	inositol 2-dehydrogenase activity
D5R92_RS05145	COG1328	CTP reductase activity
D5R92_RS05175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5R92_RS05180	COG4472	Bacterial protein of unknown function (DUF965)
D5R92_RS05185	COG1393	Belongs to the ArsC family
D5R92_RS05190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5R92_RS05200	COG0519	Catalyzes the synthesis of GMP from XMP
D5R92_RS05215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D5R92_RS05235	COG0018	arginyl-trna synthetase
D5R92_RS05240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5R92_RS05250	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5R92_RS05290	COG5002	protein histidine kinase activity
D5R92_RS05330	COG3759	membrane
D5R92_RS05340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5R92_RS05350	COG0305	Participates in initiation and elongation during chromosome replication
D5R92_RS05355	COG0359	binds to the 23S rRNA
D5R92_RS05380	COG1760	l-serine dehydratase
D5R92_RS05385	COG1760	l-serine dehydratase
D5R92_RS05395	COG0741	lytic transglycosylase activity
D5R92_RS05415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5R92_RS05425	COG0612	Peptidase, M16
D5R92_RS05430	COG0612	Peptidase, M16
D5R92_RS05460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5R92_RS05465	COG0488	(ABC) transporter
D5R92_RS05495	COG3328	transposase activity
D5R92_RS05500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5R92_RS05505	COG1475	DNA binding
D5R92_RS05510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5R92_RS05515	COG0592	DNA-directed DNA polymerase activity
D5R92_RS05525	COG0012	GTP binding
D5R92_RS05530	COG0193	aminoacyl-tRNA hydrolase activity
D5R92_RS05535	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5R92_RS05540	COG2244	polysaccharide biosynthetic process
D5R92_RS05545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D5R92_RS05575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5R92_RS05600	COG0531	amino acid
D5R92_RS05610	COG2801	Transposase and inactivated derivatives
D5R92_RS05615	COG3328	transposase activity
D5R92_RS05625	COG2801	Transposase and inactivated derivatives
D5R92_RS05810	COG3942	CHAP domain
D5R92_RS05820	COG0436	Aminotransferase
D5R92_RS05830	COG0416	fatty acid biosynthetic process
D5R92_RS05835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5R92_RS05840	COG2188	Transcriptional regulator
D5R92_RS05845	COG2222	sugar isomerase
D5R92_RS05865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5R92_RS05870	COG3715	PTS system
D5R92_RS05875	COG3716	PTS system mannose fructose sorbose family IID component
D5R92_RS05880	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5R92_RS05880	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5R92_RS05900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D5R92_RS05910	COG2255	four-way junction helicase activity
D5R92_RS05915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D5R92_RS05925	COG2755	lipolytic protein G-D-S-L family
D5R92_RS05925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5R92_RS05930	COG1454	alcohol dehydrogenase
D5R92_RS05930	COG1012	belongs to the aldehyde dehydrogenase family
D5R92_RS05950	COG0051	transcription antitermination factor activity, RNA binding
D5R92_RS05955	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5R92_RS05960	COG0088	Forms part of the polypeptide exit tunnel
D5R92_RS05965	COG0089	rRNA binding
D5R92_RS05985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5R92_RS06050	COG0200	Binds to the 23S rRNA
D5R92_RS06055	COG0201	protein transport
D5R92_RS06060	COG0563	adenylate kinase activity
D5R92_RS06080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5R92_RS06245	COG3328	transposase activity
D5R92_RS06255	COG1131	(ABC) transporter
D5R92_RS06260	COG1131	(ABC) transporter
D5R92_RS06305	COG1064	alcohol dehydrogenase
D5R92_RS06340	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D5R92_RS06355	COG1252	NADH dehydrogenase
D5R92_RS06360	COG1271	oxidase subunit
D5R92_RS06365	COG1294	oxidase, subunit
D5R92_RS06370	COG4988	ABC transporter
D5R92_RS06375	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D5R92_RS06380	COG0142	geranyltranstransferase activity
D5R92_RS06385	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D5R92_RS06395	COG1121	(ABC) transporter
D5R92_RS06400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5R92_RS06410	COG4499	WXG100 protein secretion system (Wss), protein YukC
D5R92_RS06410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5R92_RS06420	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5R92_RS06430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5R92_RS06435	COG1459	type II secretion system
D5R92_RS06440	COG4537	Required for transformation and DNA binding
D5R92_RS06465	COG0827	DNA restriction-modification system
D5R92_RS06490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5R92_RS06495	COG1363	Peptidase, m42
D5R92_RS06505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5R92_RS06510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5R92_RS06535	COG4120	Belongs to the binding-protein-dependent transport system permease family
D5R92_RS06540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5R92_RS06545	COG1428	Deoxynucleoside kinase
D5R92_RS06550	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5R92_RS06555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D5R92_RS06595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D5R92_RS06605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D5R92_RS06610	COG1349	DNA-binding transcription factor activity
D5R92_RS06615	COG1882	Formate acetyltransferase
D5R92_RS06695	COG1028	Short-chain dehydrogenase reductase Sdr
D5R92_RS06705	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D5R92_RS06710	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5R92_RS06715	COG3715	PTS system
D5R92_RS06720	COG3716	PTS system mannose fructose sorbose family IID component
D5R92_RS06730	COG1609	Transcriptional regulator
D5R92_RS06735	COG5492	domain, Protein
D5R92_RS06740	COG1131	(ABC) transporter
D5R92_RS06750	COG4585	Histidine kinase
D5R92_RS06750	COG2203	Gaf domain
D5R92_RS06755	COG2197	response regulator
D5R92_RS06765	COG4978	Transcriptional regulator
D5R92_RS06765	COG0789	Transcriptional regulator
D5R92_RS06780	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5R92_RS06785	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D5R92_RS06790	COG1012	belongs to the aldehyde dehydrogenase family
D5R92_RS06795	COG1882	Formate acetyltransferase
D5R92_RS06800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D5R92_RS06815	COG1454	alcohol dehydrogenase
D5R92_RS06815	COG1012	belongs to the aldehyde dehydrogenase family
D5R92_RS06830	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
D5R92_RS06845	COG1012	belongs to the aldehyde dehydrogenase family
D5R92_RS06845	COG1454	alcohol dehydrogenase
D5R92_RS06850	COG4869	propanediol catabolic process
D5R92_RS06885	COG0577	efflux transmembrane transporter activity
D5R92_RS06890	COG1136	(ABC) transporter
D5R92_RS06895	COG0745	RESPONSE REGULATOR receiver
D5R92_RS06900	COG5002	protein histidine kinase activity
D5R92_RS06910	COG1396	sequence-specific DNA binding
D5R92_RS06955	COG1131	(ABC) transporter
D5R92_RS06970	COG3328	transposase activity
D5R92_RS07000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5R92_RS07005	COG0512	Glutamine amidotransferase of anthranilate synthase
D5R92_RS07010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5R92_RS07015	COG0154	amidase activity
D5R92_RS07030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D5R92_RS07045	COG1263	PTS System
D5R92_RS07045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5R92_RS07045	COG2190	(PTS) system
D5R92_RS07055	COG1363	Peptidase, m42
D5R92_RS07065	COG0737	Belongs to the 5'-nucleotidase family
D5R92_RS07095	COG3842	ATPase activity
D5R92_RS07110	COG1523	belongs to the glycosyl hydrolase 13 family
D5R92_RS07115	COG1609	Transcriptional regulator
D5R92_RS07120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D5R92_RS07125	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D5R92_RS07130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5R92_RS07140	COG1862	Preprotein translocase
D5R92_RS07150	COG4589	Belongs to the CDS family
D5R92_RS07160	COG0442	prolyl-tRNA aminoacylation
D5R92_RS07190	COG0242	peptide deformylase activity
D5R92_RS07205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D5R92_RS07220	COG1045	serine acetyltransferase
D5R92_RS07230	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D5R92_RS07260	COG0383	alpha-mannosidase activity
D5R92_RS07275	COG4209	transmembrane transport
D5R92_RS07280	COG0395	ABC-type sugar transport system, permease component
D5R92_RS07285	COG1653	transport
D5R92_RS07295	COG2972	Histidine kinase
D5R92_RS07300	COG2207	Transcriptional regulator
D5R92_RS07300	COG4753	response regulator
D5R92_RS07305	COG2723	6-phospho-beta-galactosidase activity
D5R92_RS07325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5R92_RS07355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D5R92_RS07360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5R92_RS07395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5R92_RS07445	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
D5R92_RS07460	COG2851	Citrate transporter
D5R92_RS07470	COG0511	ligase activity, forming carbon-carbon bonds
D5R92_RS07475	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
D5R92_RS07480	COG3052	prosthetic group binding
D5R92_RS07505	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D5R92_RS07515	COG0392	lysyltransferase activity
D5R92_RS07515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D5R92_RS07530	COG1122	ATPase activity
D5R92_RS07535	COG4720	Psort location CytoplasmicMembrane, score
D5R92_RS07580	COG0527	aspartate kinase activity
D5R92_RS07585	COG0101	tRNA pseudouridine synthase activity
D5R92_RS07590	COG0352	thiamine-phosphate diphosphorylase activity
D5R92_RS07590	COG0351	phosphomethylpyrimidine kinase
D5R92_RS07595	COG4720	Psort location CytoplasmicMembrane, score
D5R92_RS07605	COG0668	transmembrane transport
D5R92_RS07610	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5R92_RS07615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5R92_RS07620	COG3343	RNA polymerase activity
D5R92_RS07630	COG3275	phosphorelay sensor kinase activity
D5R92_RS07635	COG3279	Response regulator of the LytR AlgR family
D5R92_RS07645	COG1346	cytolysis
D5R92_RS07695	COG1126	abc transporter atp-binding protein
D5R92_RS07700	COG0765	amino acid transport
D5R92_RS07715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5R92_RS07725	COG0719	Fe-S assembly protein
D5R92_RS07730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D5R92_RS07740	COG0719	Fe-S assembly protein
D5R92_RS07755	COG1686	Belongs to the peptidase S11 family
D5R92_RS07760	COG1686	Belongs to the peptidase S11 family
D5R92_RS07765	COG4166	transmembrane transport
D5R92_RS07770	COG0601	transmembrane transport
D5R92_RS07775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5R92_RS07780	COG0444	Belongs to the ABC transporter superfamily
D5R92_RS07860	COG2137	regulation of response to DNA damage stimulus
D5R92_RS07870	COG1442	glycosyl transferase family 8
D5R92_RS07870	COG1216	Glycosyl transferase, family 2
D5R92_RS07885	COG1442	glycosyl transferase family 8
D5R92_RS07885	COG1216	Glycosyl transferase, family 2
D5R92_RS07890	COG1442	glycosyl transferase family 8
D5R92_RS07920	COG1073	alpha beta
D5R92_RS07970	COG1131	(ABC) transporter
D5R92_RS07975	COG2207	Transcriptional regulator
D5R92_RS07985	COG1175	transmembrane transport
D5R92_RS07990	COG0395	ABC-type sugar transport system, permease component
D5R92_RS08005	COG1247	-acetyltransferase
D5R92_RS08025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5R92_RS08030	COG0586	Pfam SNARE associated Golgi protein
D5R92_RS08035	COG1668	transmembrane transport
D5R92_RS08040	COG4152	abc transporter atp-binding protein
D5R92_RS08075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5R92_RS08120	COG3591	Belongs to the peptidase S1B family
D5R92_RS08155	COG2972	Histidine kinase
D5R92_RS08160	COG2207	Transcriptional regulator
D5R92_RS08160	COG4753	response regulator
D5R92_RS08165	COG1840	ABC-type Fe3 transport system, periplasmic component
D5R92_RS08170	COG3842	ATPase activity
D5R92_RS08175	COG1178	ABC-type Fe3 transport system permease component
D5R92_RS08180	COG0673	inositol 2-dehydrogenase activity
D5R92_RS08210	COG0454	-acetyltransferase
D5R92_RS08220	COG1288	antiporter activity
D5R92_RS08225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5R92_RS08230	COG0549	Belongs to the carbamate kinase family
D5R92_RS08245	COG0742	ribosomal rna small subunit methyltransferase
D5R92_RS08250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5R92_RS08255	COG3480	Lon protease (S16) C-terminal proteolytic domain
D5R92_RS08260	COG1609	Transcriptional regulator
D5R92_RS08265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5R92_RS08270	COG1869	D-ribose catabolic process
D5R92_RS08280	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5R92_RS08285	COG1879	ABC-type sugar transport system periplasmic component
D5R92_RS08290	COG0737	Belongs to the 5'-nucleotidase family
D5R92_RS08295	COG4470	Protein conserved in bacteria
D5R92_RS08300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5R92_RS08310	COG1132	(ABC) transporter
D5R92_RS08315	COG1132	(ABC) transporter
D5R92_RS08330	COG1940	carbohydrate kinase activity
D5R92_RS08335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5R92_RS08340	COG1217	gtp-binding protein TYPA
D5R92_RS08350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D5R92_RS08355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5R92_RS08375	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5R92_RS08380	COG1799	cell septum assembly
D5R92_RS08395	COG3599	regulation of cell shape
D5R92_RS08415	COG0542	response to heat
D5R92_RS08420	COG4703	Protein of unknown function (DUF1797)
D5R92_RS08425	COG0765	amino acid transport
D5R92_RS08430	COG1126	abc transporter atp-binding protein
D5R92_RS08435	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5R92_RS08455	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D5R92_RS08460	COG1438	arginine binding
D5R92_RS08465	COG0497	DNA recombination
D5R92_RS08480	COG2755	lipolytic protein G-D-S-L family
D5R92_RS08495	COG2217	Heavy metal translocating P-type atpase
D5R92_RS08505	COG0167	dihydroorotate dehydrogenase activity
D5R92_RS08515	COG1827	regulation of RNA biosynthetic process
D5R92_RS08530	COG0768	penicillin binding
D5R92_RS08580	COG0561	phosphatase activity
D5R92_RS08585	COG0513	Belongs to the DEAD box helicase family
D5R92_RS08600	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D5R92_RS08605	COG0204	Acyl-transferase
D5R92_RS08610	COG1555	photosystem II stabilization
D5R92_RS08610	COG1596	polysaccharide export
D5R92_RS08615	COG0658	competence protein
D5R92_RS08615	COG2333	competence protein COMEC
D5R92_RS08650	COG1187	pseudouridine synthase activity
D5R92_RS08685	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5R92_RS08690	COG4122	O-methyltransferase activity
D5R92_RS08695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5R92_RS08715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5R92_RS08720	COG0436	Aminotransferase
D5R92_RS08725	COG3328	transposase activity
D5R92_RS08745	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5R92_RS08750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5R92_RS08755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D5R92_RS08775	COG0726	polysaccharide deacetylase
D5R92_RS08780	COG0513	Belongs to the DEAD box helicase family
D5R92_RS08785	COG0572	uridine kinase
D5R92_RS08800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D5R92_RS08820	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D5R92_RS08830	COG2211	Major facilitator Superfamily
D5R92_RS08835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5R92_RS08840	COG2186	Transcriptional regulator
D5R92_RS08845	COG0800	Aldolase
D5R92_RS08855	COG1312	Catalyzes the dehydration of D-mannonate
D5R92_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
D5R92_RS08885	COG4109	DRTGG domain
D5R92_RS08890	COG0024	Methionine aminopeptidase
D5R92_RS08945	COG3328	transposase activity
D5R92_RS08950	COG3328	transposase activity
D5R92_RS08965	COG0577	efflux transmembrane transporter activity
D5R92_RS08965	COG1136	(ABC) transporter
D5R92_RS08975	COG0584	glycerophosphoryl diester phosphodiesterase
D5R92_RS08995	COG0318	PFAM AMP-dependent synthetase and ligase
D5R92_RS09000	COG1960	acyl-CoA dehydrogenase activity
D5R92_RS09005	COG0427	acetyl-CoA hydrolase
D5R92_RS09010	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5R92_RS09010	COG1024	Enoyl-CoA hydratase
D5R92_RS09015	COG0183	Belongs to the thiolase family
D5R92_RS09020	COG0583	DNA-binding transcription factor activity
D5R92_RS09025	COG2050	protein possibly involved in aromatic compounds catabolism
D5R92_RS09030	COG4619	ABC transporter
D5R92_RS09035	COG0390	transport system, permease component
D5R92_RS09040	COG4868	Belongs to the UPF0371 family
D5R92_RS09045	COG2814	Major facilitator Superfamily
D5R92_RS09060	COG1187	pseudouridine synthase activity
D5R92_RS09065	COG0598	Magnesium transport protein CorA
D5R92_RS09070	COG1132	(ABC) transporter
D5R92_RS09080	COG2309	aminopeptidase activity
D5R92_RS09090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5R92_RS09105	COG0488	(ABC) transporter
D5R92_RS09110	COG1126	abc transporter atp-binding protein
D5R92_RS09120	COG0556	nucleotide-excision repair
D5R92_RS09135	COG1696	Membrane protein involved in D-alanine export
D5R92_RS09140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5R92_RS09145	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D5R92_RS09150	COG2182	Extracellular solute-binding protein
D5R92_RS09155	COG0366	Alpha amylase catalytic
D5R92_RS09165	COG1175	transmembrane transport
D5R92_RS09170	COG3833	ABC-type maltose transport systems, permease component
D5R92_RS09185	COG3833	ABC-type maltose transport systems, permease component
D5R92_RS09190	COG1175	transmembrane transport
D5R92_RS09200	COG1609	Transcriptional regulator
D5R92_RS09205	COG1640	4-alpha-glucanotransferase
D5R92_RS09210	COG0058	SHG alpha-glucan phosphorylase activity
D5R92_RS09220	COG1054	Belongs to the UPF0176 family
D5R92_RS09245	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5R92_RS09260	COG0300	oxidoreductase activity
D5R92_RS09265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D5R92_RS09265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5R92_RS09270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5R92_RS09280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5R92_RS09285	COG3328	transposase activity
D5R92_RS09290	COG2384	SAM-dependent methyltransferase
D5R92_RS09305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5R92_RS09310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D5R92_RS09320	COG1088	dTDP-glucose 4,6-dehydratase activity
D5R92_RS09330	COG2706	6-phosphogluconolactonase activity
D5R92_RS09335	COG1051	belongs to the nudix hydrolase family
D5R92_RS09340	COG0628	permease
D5R92_RS09345	COG0457	Tetratricopeptide repeat
D5R92_RS09350	COG1293	RNA-binding protein homologous to eukaryotic snRNP
D5R92_RS09365	COG3842	ATPase activity
D5R92_RS09385	COG0488	(ABC) transporter
D5R92_RS09395	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5R92_RS09400	COG0022	dehydrogenase e1 component
D5R92_RS09400	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5R92_RS09405	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5R92_RS09415	COG0095	Lipoate-protein ligase
D5R92_RS09420	COG3442	glutamine amidotransferase
D5R92_RS09425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D5R92_RS09430	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D5R92_RS09440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5R92_RS09450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5R92_RS09480	COG1518	maintenance of DNA repeat elements
D5R92_RS09485	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D5R92_RS09505	COG0481	GTPase activity
D5R92_RS09515	COG1418	mRNA catabolic process
D5R92_RS09530	COG0656	L-ascorbic acid biosynthetic process
D5R92_RS09545	COG2259	Doxx family
D5R92_RS09550	COG1011	Hydrolase
D5R92_RS09555	COG1012	belongs to the aldehyde dehydrogenase family
D5R92_RS09560	COG0322	excinuclease ABC activity
D5R92_RS09580	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D5R92_RS09590	COG1393	Belongs to the ArsC family
D5R92_RS09600	COG0813	purine-nucleoside phosphorylase activity
D5R92_RS09610	COG0583	DNA-binding transcription factor activity
D5R92_RS09615	COG1316	TRANSCRIPTIONal
D5R92_RS09640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D5R92_RS09650	COG0438	transferase activity, transferring glycosyl groups
D5R92_RS09650	COG4641	Protein conserved in bacteria
D5R92_RS09655	COG0110	maltose O-acetyltransferase activity
D5R92_RS09720	COG1881	PFAM PEBP family protein
D5R92_RS09730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5R92_RS09735	COG0765	amino acid transport
D5R92_RS09740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D5R92_RS09745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D5R92_RS09755	COG0187	DNA topoisomerase II activity
D5R92_RS09770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5R92_RS09790	COG0539	negative regulation of cytoplasmic translation
D5R92_RS09820	COG1131	(ABC) transporter
D5R92_RS09825	COG1725	Transcriptional regulator
D5R92_RS09835	COG0205	6-phosphofructokinase activity
D5R92_RS09840	COG0469	pyruvate kinase activity
D5R92_RS09855	COG2213	PTS system mannitol-specific
D5R92_RS09860	COG3711	transcriptional antiterminator
D5R92_RS09865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5R92_RS09870	COG0246	Mannitol dehydrogenase
D5R92_RS09875	COG2824	Alkylphosphonate utilization operon protein PhnA
D5R92_RS09880	COG0765	amino acid transport
D5R92_RS09885	COG1126	abc transporter atp-binding protein
D5R92_RS09890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5R92_RS09900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5R92_RS09905	COG1115	amino acid carrier protein
D5R92_RS09915	COG2261	transglycosylase associated protein
D5R92_RS09960	COG1136	(ABC) transporter
D5R92_RS10000	COG0196	riboflavin kinase activity
D5R92_RS10010	COG4476	Belongs to the UPF0223 family
D5R92_RS10015	COG0483	inositol monophosphate 1-phosphatase activity
D5R92_RS10025	COG0573	inorganic phosphate transmembrane transporter activity
D5R92_RS10030	COG0581	inorganic phosphate transmembrane transporter activity
D5R92_RS10045	COG0704	Plays a role in the regulation of phosphate uptake
D5R92_RS10055	COG0745	RESPONSE REGULATOR receiver
D5R92_RS10060	COG5002	protein histidine kinase activity
D5R92_RS10075	COG2813	Specifically methylates the guanine in position
D5R92_RS10080	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D5R92_RS10085	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D5R92_RS10090	COG0295	cytidine deaminase activity
D5R92_RS10095	COG1744	ABC transporter substrate-binding protein PnrA-like
D5R92_RS10100	COG3845	ABC transporter
D5R92_RS10105	COG4603	Belongs to the binding-protein-dependent transport system permease family
D5R92_RS10110	COG1079	Belongs to the binding-protein-dependent transport system permease family
D5R92_RS10125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5R92_RS10130	COG4684	Psort location CytoplasmicMembrane, score
D5R92_RS10135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5R92_RS10140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5R92_RS10150	COG2759	Belongs to the formate--tetrahydrofolate ligase family