locus-tag	class	description
SIR_RS09755	COG0592	DNA-directed DNA polymerase activity
SIR_RS09770	COG0012	GTP binding
SIR_RS09775	COG0193	aminoacyl-tRNA hydrolase activity
SIR_RS09780	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SIR_RS09785	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SIR_RS09800	COG0037	tRNA processing
SIR_RS09805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SIR_RS09810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SIR_RS09930	COG1792	Involved in formation and maintenance of cell shape
SIR_RS09940	COG3942	CHAP domain
SIR_RS09945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SIR_RS09950	COG0436	Aminotransferase
SIR_RS09955	COG1381	Involved in DNA repair and RecF pathway recombination
SIR_RS09965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SIR_RS09970	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SIR_RS09975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SIR_RS09985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SIR_RS09990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SIR_RS09995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SIR_RS10005	COG0138	bifunctional purine biosynthesis protein purh
SIR_RS10010	COG3942	CHAP domain
SIR_RS10040	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SIR_RS10060	COG1794	racemase activity, acting on amino acids and derivatives
SIR_RS10075	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SIR_RS10090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SIR_RS10100	COG3716	PTS system mannose fructose sorbose family IID component
SIR_RS10110	COG2222	sugar isomerase
SIR_RS10130	COG2255	four-way junction helicase activity
SIR_RS10155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SIR_RS10170	COG1454	alcohol dehydrogenase
SIR_RS10170	COG1012	belongs to the aldehyde dehydrogenase family
SIR_RS10175	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SIR_RS10185	COG1175	transmembrane transport
SIR_RS10190	COG0395	ABC-type sugar transport system, permease component
SIR_RS10195	COG2731	YhcH YjgK YiaL family protein
SIR_RS10205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIR_RS10225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SIR_RS10225	COG1263	PTS System
SIR_RS10230	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SIR_RS10245	COG1269	ATP hydrolysis coupled proton transport
SIR_RS10250	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SIR_RS10260	COG1527	subunit (C
SIR_RS10270	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SIR_RS10275	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SIR_RS10280	COG1394	ATPase activity, coupled to movement of substances
SIR_RS10285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SIR_RS10305	COG4932	domain protein
SIR_RS10305	COG1388	LysM domain
SIR_RS10320	COG1846	Transcriptional regulator
SIR_RS10325	COG1121	(ABC) transporter
SIR_RS10330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SIR_RS10335	COG0803	Belongs to the bacterial solute-binding protein 9 family
SIR_RS10335	COG3443	Belongs to the bacterial solute-binding protein 9 family
SIR_RS10345	COG2217	Heavy metal translocating P-type atpase
SIR_RS10355	COG0564	pseudouridine synthase activity
SIR_RS10360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SIR_RS10385	COG0052	Belongs to the universal ribosomal protein uS2 family
SIR_RS10390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SIR_RS10400	COG4463	regulation of RNA biosynthetic process
SIR_RS10415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SIR_RS10420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SIR_RS10440	COG1396	sequence-specific DNA binding
SIR_RS10465	COG1131	(ABC) transporter
SIR_RS10490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SIR_RS10525	COG0166	Belongs to the GPI family
SIR_RS10535	COG0594	ribonuclease P activity
SIR_RS10560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SIR_RS10565	COG0084	hydrolase, TatD family'
SIR_RS10575	COG4842	Belongs to the WXG100 family
SIR_RS10625	COG4499	WXG100 protein secretion system (Wss), protein YukC
SIR_RS10630	COG1674	ftsk spoiiie
SIR_RS10755	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SIR_RS10770	COG1162	GTPase activity
SIR_RS10780	COG1564	THIamine pyrophosphokinase
SIR_RS10790	COG3481	metal-dependent phosphohydrolase, HD sub domain
SIR_RS10795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SIR_RS10800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SIR_RS10805	COG0049	tRNA binding
SIR_RS10810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SIR_RS10830	COG1214	PFAM Peptidase M22, glycoprotease
SIR_RS10840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SIR_RS10865	COG0789	Transcriptional regulator
SIR_RS10875	COG2081	HI0933 family
SIR_RS10890	COG0584	glycerophosphoryl diester phosphodiesterase
SIR_RS10910	COG1131	(ABC) transporter
SIR_RS10920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SIR_RS10925	COG2936	dipeptidyl-peptidase activity
SIR_RS10930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SIR_RS10965	COG1304	FMN binding
SIR_RS10975	COG3425	synthase
SIR_RS10990	COG1882	Formate acetyltransferase
SIR_RS10995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SIR_RS11000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SIR_RS11005	COG0681	Belongs to the peptidase S26 family
SIR_RS11025	COG1193	negative regulation of DNA recombination
SIR_RS11035	COG3118	belongs to the thioredoxin family
SIR_RS11055	COG0531	amino acid
SIR_RS11060	COG0668	transmembrane transport
SIR_RS11065	COG5504	Zn-dependent protease
SIR_RS11075	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SIR_RS11080	COG0167	dihydroorotate dehydrogenase activity
SIR_RS11085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SIR_RS11085	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SIR_RS11090	COG0402	S-adenosylhomocysteine deaminase activity
SIR_RS11105	COG1136	(ABC) transporter
SIR_RS11110	COG1940	carbohydrate kinase activity
SIR_RS11115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SIR_RS11130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SIR_RS11135	COG1447	Phosphotransferase system cellobiose-specific component IIA
SIR_RS11185	COG1401	restriction endodeoxyribonuclease activity
SIR_RS11205	COG0745	RESPONSE REGULATOR receiver
SIR_RS11210	COG5002	protein histidine kinase activity
SIR_RS11225	COG0366	Alpha amylase catalytic
SIR_RS11235	COG1122	ATPase activity
SIR_RS11245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SIR_RS11255	COG2134	cdp-diacylglycerol pyrophosphatase
SIR_RS11290	COG0629	single-stranded DNA binding
SIR_RS11295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SIR_RS11315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SIR_RS11325	COG0006	proline dipeptidase activity
SIR_RS11330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SIR_RS11425	COG4720	Psort location CytoplasmicMembrane, score
SIR_RS11460	COG1122	ATPase activity
SIR_RS11470	COG4221	oxidoreductase activity
SIR_RS11475	COG1442	glycosyl transferase family 8
SIR_RS11485	COG0357	Ribosomal RNA small subunit methyltransferase G
SIR_RS11490	COG1704	LemA family
SIR_RS11495	COG0501	Belongs to the peptidase M48B family
SIR_RS11510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SIR_RS11515	COG0745	RESPONSE REGULATOR receiver
SIR_RS11520	COG2190	(PTS) system
SIR_RS11520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SIR_RS11520	COG1263	PTS System
SIR_RS11525	COG2190	(PTS) system
SIR_RS11525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SIR_RS11525	COG1263	PTS System
SIR_RS11540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SIR_RS11550	COG1484	DNA-dependent DNA replication
SIR_RS11560	COG1160	GTP binding
SIR_RS11565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SIR_RS11575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SIR_RS11590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SIR_RS11610	COG1254	Belongs to the acylphosphatase family
SIR_RS11615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SIR_RS11640	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SIR_RS11645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SIR_RS11655	COG0517	IMP dehydrogenase activity
SIR_RS11660	COG4974	Belongs to the 'phage' integrase family
SIR_RS11665	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SIR_RS11675	COG1187	pseudouridine synthase activity
SIR_RS11685	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SIR_RS11690	COG0569	domain protein
SIR_RS11700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SIR_RS11705	COG0671	phosphoesterase, PA-phosphatase related
SIR_RS11715	COG1242	4 iron, 4 sulfur cluster binding
SIR_RS11720	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SIR_RS11730	COG0025	NhaP-type Na H and K H
SIR_RS11740	COG0494	nUDIX hydrolase
SIR_RS11745	COG2378	regulation of single-species biofilm formation
SIR_RS11755	COG0542	response to heat
SIR_RS11760	COG4703	Protein of unknown function (DUF1797)
SIR_RS11780	COG1136	(ABC) transporter
SIR_RS11785	COG0577	efflux transmembrane transporter activity
SIR_RS11790	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SIR_RS11795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SIR_RS11810	COG1175	transmembrane transport
SIR_RS11815	COG0395	ABC-type sugar transport system, permease component
SIR_RS11820	COG1621	beta-fructofuranosidase activity
SIR_RS11835	COG1570	exodeoxyribonuclease VII activity
SIR_RS11840	COG1722	exodeoxyribonuclease VII activity
SIR_RS11850	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SIR_RS11855	COG1438	arginine binding
SIR_RS11860	COG0497	DNA recombination
SIR_RS11865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SIR_RS11870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SIR_RS11875	COG4604	ABC transporter, ATP-binding protein
SIR_RS11880	COG4605	iron ion homeostasis
SIR_RS11885	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SIR_RS11890	COG1307	EDD domain protein, DegV family
SIR_RS11900	COG0735	belongs to the Fur family
SIR_RS11905	COG0588	phosphoglycerate mutase activity
SIR_RS11910	COG0768	penicillin binding
SIR_RS11915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SIR_RS11920	COG1181	Belongs to the D-alanine--D-alanine ligase family
SIR_RS11925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SIR_RS11945	COG3620	sequence-specific DNA binding
SIR_RS11955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SIR_RS11970	COG0513	Belongs to the DEAD box helicase family
SIR_RS11985	COG0698	ribose 5-phosphate isomerase
SIR_RS12005	COG3775	system Galactitol-specific IIC component
SIR_RS12010	COG1105	Belongs to the carbohydrate kinase PfkB family
SIR_RS12015	COG3064	Membrane
SIR_RS12015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SIR_RS12015	COG3583	domain protein
SIR_RS12020	COG3711	transcriptional antiterminator
SIR_RS12025	COG1447	Phosphotransferase system cellobiose-specific component IIA
SIR_RS12030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SIR_RS12030	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SIR_RS12035	COG2723	6-phospho-beta-galactosidase activity
SIR_RS12040	COG1755	Isoprenylcysteine carboxyl methyltransferase
SIR_RS12045	COG2827	Endonuclease containing a URI domain
SIR_RS12050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SIR_RS12055	COG0254	rRNA binding
SIR_RS12060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SIR_RS12065	COG0716	FMN binding
SIR_RS12075	COG0628	permease
SIR_RS12085	COG0028	Belongs to the TPP enzyme family
SIR_RS12090	COG3527	Alpha-acetolactate decarboxylase
SIR_RS12095	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SIR_RS12110	COG3842	ATPase activity
SIR_RS12120	COG4443	Transcriptional Coactivator p15 (PC4)
SIR_RS12155	COG4152	abc transporter atp-binding protein
SIR_RS12160	COG1668	transmembrane transport
SIR_RS12165	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SIR_RS12170	COG1074	ATP-dependent DNA helicase activity
SIR_RS12175	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SIR_RS12190	COG0297	glycogen (starch) synthase activity
SIR_RS12195	COG0058	SHG alpha-glucan phosphorylase activity
SIR_RS12205	COG0356	it plays a direct role in the translocation of protons across the membrane
SIR_RS12210	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SIR_RS12215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SIR_RS12220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SIR_RS12225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SIR_RS12255	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SIR_RS12275	COG1132	(ABC) transporter
SIR_RS12295	COG1346	cytolysis
SIR_RS12300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SIR_RS12315	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SIR_RS12320	COG0492	ferredoxin-NADP+ reductase activity
SIR_RS12330	COG1349	DNA-binding transcription factor activity
SIR_RS12335	COG1105	Belongs to the carbohydrate kinase PfkB family
SIR_RS12340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SIR_RS12340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SIR_RS12340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SIR_RS12350	COG1307	EDD domain protein, DegV family
SIR_RS12355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SIR_RS12360	COG0617	tRNA 3'-terminal CCA addition
SIR_RS12365	COG0488	(ABC) transporter
SIR_RS12380	COG0072	phenylalanine-tRNA ligase activity
SIR_RS12380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIR_RS12385	COG1268	BioY protein
SIR_RS12390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIR_RS12395	COG0577	efflux transmembrane transporter activity
SIR_RS12400	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SIR_RS12405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SIR_RS12425	COG0300	oxidoreductase activity
SIR_RS12440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SIR_RS12440	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SIR_RS12445	COG1131	(ABC) transporter
SIR_RS12460	COG0205	6-phosphofructokinase activity
SIR_RS12465	COG0469	pyruvate kinase activity
SIR_RS12480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SIR_RS12485	COG0210	DNA helicase
SIR_RS12490	COG0494	nUDIX hydrolase
SIR_RS12500	COG2375	cellular response to nickel ion
SIR_RS12500	COG1132	(ABC) transporter
SIR_RS12505	COG1132	(ABC) transporter
SIR_RS12525	COG0456	acetyltransferase
SIR_RS12535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SIR_RS12540	COG0196	riboflavin kinase activity
SIR_RS12545	COG1393	Belongs to the ArsC family
SIR_RS12550	COG4476	Belongs to the UPF0223 family
SIR_RS12555	COG0483	inositol monophosphate 1-phosphatase activity
SIR_RS12560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SIR_RS12560	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SIR_RS12570	COG0573	inorganic phosphate transmembrane transporter activity
SIR_RS12575	COG0581	inorganic phosphate transmembrane transporter activity
SIR_RS12580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SIR_RS12585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SIR_RS12590	COG0704	Plays a role in the regulation of phosphate uptake
SIR_RS12595	COG2003	Belongs to the UPF0758 family
SIR_RS12620	COG1104	cysteine desulfurase activity
SIR_RS12625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SIR_RS12635	COG2357	RelA SpoT domain protein
SIR_RS12645	COG0564	pseudouridine synthase activity
SIR_RS12650	COG0280	phosphate acetyltransferase
SIR_RS12655	COG1194	a g-specific adenine glycosylase
SIR_RS12670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SIR_RS12675	COG4684	Psort location CytoplasmicMembrane, score
SIR_RS12680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SIR_RS12695	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SIR_RS12710	COG0583	DNA-binding transcription factor activity
SIR_RS12720	COG0281	malic enzyme
SIR_RS12770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SIR_RS12775	COG0477	Major facilitator Superfamily
SIR_RS12780	COG3689	TIGRFAM TIGR03943 family protein
SIR_RS12785	COG0701	Predicted permease
SIR_RS12790	COG2183	response to ionizing radiation
SIR_RS12795	COG3091	SprT-like family
SIR_RS12805	COG1051	belongs to the nudix hydrolase family
SIR_RS12810	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SIR_RS12815	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SIR_RS12840	COG0826	peptidase U32
SIR_RS12865	COG0488	(ABC) transporter
SIR_RS12875	COG3442	glutamine amidotransferase
SIR_RS12880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SIR_RS12885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SIR_RS12895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SIR_RS12900	COG0560	Phosphoserine phosphatase
SIR_RS12925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SIR_RS12935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SIR_RS12950	COG0726	polysaccharide deacetylase
SIR_RS12960	COG0673	inositol 2-dehydrogenase activity
SIR_RS12965	COG0572	uridine kinase
SIR_RS12970	COG2195	Cleaves the N-terminal amino acid of tripeptides
SIR_RS12980	COG0561	phosphatase activity
SIR_RS12985	COG0481	GTPase activity
SIR_RS12990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SIR_RS12995	COG3842	ATPase activity
SIR_RS13000	COG1176	ABC-type spermidine putrescine transport system, permease component I
SIR_RS13005	COG1177	transmembrane transport
SIR_RS13015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SIR_RS13020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SIR_RS13030	COG2207	Transcriptional regulator
SIR_RS13030	COG3708	Transcriptional regulator
SIR_RS13035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SIR_RS13040	COG0222	ribosome binding
SIR_RS13055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SIR_RS13060	COG0336	Belongs to the RNA methyltransferase TrmD family
SIR_RS13065	COG0803	Belongs to the bacterial solute-binding protein 9 family
SIR_RS13065	COG3443	Belongs to the bacterial solute-binding protein 9 family
SIR_RS13085	COG1956	GAF domain-containing protein
SIR_RS13090	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SIR_RS13095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SIR_RS13105	COG0251	oxidation-reduction process
SIR_RS13110	COG0626	cystathionine gamma-synthase activity
SIR_RS13115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIR_RS13125	COG2860	membrane
SIR_RS13135	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SIR_RS13135	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SIR_RS13140	COG1609	Transcriptional regulator
SIR_RS13145	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SIR_RS13150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SIR_RS13160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SIR_RS13170	COG0726	polysaccharide deacetylase
SIR_RS13180	COG0083	homoserine kinase activity
SIR_RS13220	COG1204	response to ionizing radiation
SIR_RS13230	COG2184	nucleotidyltransferase activity
SIR_RS13270	COG2814	Major facilitator Superfamily
SIR_RS13280	COG0543	2 iron, 2 sulfur cluster binding
SIR_RS13285	COG0167	dihydroorotate dehydrogenase activity
SIR_RS13290	COG0284	orotidine-5'-phosphate decarboxylase activity
SIR_RS13300	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SIR_RS13305	COG4479	Belongs to the UPF0346 family
SIR_RS13310	COG1702	phosphate starvation-inducible protein PhoH
SIR_RS13330	COG0686	Belongs to the AlaDH PNT family
SIR_RS13345	COG1132	(ABC) transporter
SIR_RS13350	COG1132	(ABC) transporter
SIR_RS13360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SIR_RS13385	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SIR_RS13390	COG0237	dephospho-CoA kinase activity
SIR_RS13395	COG2814	Major facilitator Superfamily
SIR_RS13405	COG0557	exoribonuclease II activity
SIR_RS13410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SIR_RS13415	COG1555	photosystem II stabilization
SIR_RS13420	COG0658	competence protein
SIR_RS13420	COG2333	competence protein COMEC
SIR_RS13435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SIR_RS13440	COG1051	belongs to the nudix hydrolase family
SIR_RS13445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SIR_RS13450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SIR_RS13455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SIR_RS13460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SIR_RS13465	COG4109	DRTGG domain
SIR_RS13480	COG1846	Transcriptional regulator
SIR_RS13495	COG2801	Transposase and inactivated derivatives
SIR_RS13500	COG2246	polysaccharide biosynthetic process
SIR_RS13505	COG4708	membrane
SIR_RS13515	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SIR_RS13520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SIR_RS13525	COG1597	lipid kinase activity
SIR_RS13530	COG1523	belongs to the glycosyl hydrolase 13 family
SIR_RS13535	COG0228	four-way junction DNA binding
SIR_RS13540	COG1837	Belongs to the UPF0109 family
SIR_RS13545	COG1827	regulation of RNA biosynthetic process
SIR_RS13560	COG3142	Participates in the control of copper homeostasis
SIR_RS13565	COG2315	Protein conserved in bacteria
SIR_RS13570	COG1132	(ABC) transporter
SIR_RS13575	COG1132	(ABC) transporter
SIR_RS13580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SIR_RS13590	COG1518	maintenance of DNA repeat elements
SIR_RS13615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SIR_RS13625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SIR_RS13630	COG0110	maltose O-acetyltransferase activity
SIR_RS13635	COG0758	DNA mediated transformation
SIR_RS13640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SIR_RS13645	COG0135	phosphoribosylanthranilate isomerase activity
SIR_RS13650	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SIR_RS13670	COG4974	Belongs to the 'phage' integrase family
SIR_RS13675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SIR_RS13685	COG2188	Transcriptional regulator
SIR_RS13700	COG0741	lytic transglycosylase activity
SIR_RS13710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SIR_RS13715	COG0009	L-threonylcarbamoyladenylate synthase
SIR_RS13720	COG2890	protein-(glutamine-N5) methyltransferase activity
SIR_RS13730	COG1435	thymidine kinase activity
SIR_RS13735	COG1942	4-Oxalocrotonate Tautomerase
SIR_RS13740	COG0534	Mate efflux family protein
SIR_RS13745	COG2233	PERMEase
SIR_RS13750	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SIR_RS13790	COG1053	succinate dehydrogenase
SIR_RS13790	COG0431	NADPH-dependent FMN reductase
SIR_RS13790	COG3976	FMN-binding domain protein
SIR_RS13795	COG4555	ABC transporter
SIR_RS13810	COG2972	Histidine kinase
SIR_RS13815	COG4753	response regulator
SIR_RS13815	COG2207	Transcriptional regulator
SIR_RS13820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SIR_RS13820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SIR_RS13825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SIR_RS13830	COG0785	Cytochrome C biogenesis protein
SIR_RS13840	COG2151	metal-sulfur cluster biosynthetic enzyme
SIR_RS13845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SIR_RS13850	COG0358	DNA primase activity
SIR_RS13855	COG1970	mechanosensitive ion channel activity
SIR_RS13860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SIR_RS13865	COG3764	Sortase (surface protein transpeptidase)
SIR_RS13870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SIR_RS13875	COG0039	L-malate dehydrogenase activity
SIR_RS13890	COG0539	negative regulation of cytoplasmic translation
SIR_RS13910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SIR_RS13915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SIR_RS13925	COG0187	DNA topoisomerase II activity
SIR_RS13930	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SIR_RS13940	COG2131	deaminase
SIR_RS13945	COG1309	transcriptional regulator
SIR_RS14005	COG2814	Major facilitator Superfamily
SIR_RS14010	COG0017	Asparaginyl-tRNA synthetase
SIR_RS14020	COG0436	Aminotransferase
SIR_RS14030	COG1846	Transcriptional regulator
SIR_RS14040	COG3022	response to hydroperoxide
SIR_RS14050	COG1272	protein, Hemolysin III
SIR_RS14055	COG1079	Belongs to the binding-protein-dependent transport system permease family
SIR_RS14060	COG4603	Belongs to the binding-protein-dependent transport system permease family
SIR_RS14065	COG3845	ABC transporter
SIR_RS14070	COG1744	ABC transporter substrate-binding protein PnrA-like
SIR_RS14075	COG0295	cytidine deaminase activity
SIR_RS14090	COG2813	Specifically methylates the guanine in position
SIR_RS14095	COG1072	(Pantothenic acid kinase))
SIR_RS14115	COG5002	protein histidine kinase activity
SIR_RS14120	COG0745	RESPONSE REGULATOR receiver
SIR_RS14145	COG1940	carbohydrate kinase activity
SIR_RS14150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SIR_RS14155	COG0505	Belongs to the CarA family
SIR_RS14160	COG0540	Belongs to the ATCase OTCase family
SIR_RS14170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SIR_RS14180	COG1481	regulation of sporulation
SIR_RS14185	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SIR_RS14190	COG1660	Displays ATPase and GTPase activities
SIR_RS14210	COG0647	UMP catabolic process
SIR_RS14215	COG1051	belongs to the nudix hydrolase family
SIR_RS14225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SIR_RS14245	COG0556	nucleotide-excision repair
SIR_RS14250	COG4215	(ABC) transporter
SIR_RS14260	COG0488	(ABC) transporter
SIR_RS14265	COG1132	(ABC) transporter
SIR_RS14280	COG1705	Flagellar rod assembly protein muramidase FlgJ
SIR_RS14280	COG1388	LysM domain
SIR_RS14285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SIR_RS14290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SIR_RS14300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SIR_RS14305	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SIR_RS14310	COG0038	chloride channel
SIR_RS14330	COG2824	Alkylphosphonate utilization operon protein PhnA
SIR_RS14340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SIR_RS14345	COG0564	pseudouridine synthase activity
SIR_RS14350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SIR_RS14355	COG0583	DNA-binding transcription factor activity
SIR_RS14370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SIR_RS14375	COG0446	pyridine nucleotide-disulphide oxidoreductase
SIR_RS14380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SIR_RS14390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SIR_RS14400	COG0301	tRNA thio-modification
SIR_RS14405	COG1104	cysteine desulfurase activity
SIR_RS14410	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SIR_RS14415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SIR_RS14420	COG0517	IMP dehydrogenase activity
SIR_RS14425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SIR_RS14425	COG0574	Belongs to the PEP-utilizing enzyme family
SIR_RS14435	COG0552	protein localization to endoplasmic reticulum
SIR_RS14440	COG0561	phosphatase activity
SIR_RS14445	COG0561	phosphatase activity
SIR_RS14450	COG1196	nuclear chromosome segregation
SIR_RS14455	COG0571	ribonuclease III activity
SIR_RS14460	COG2832	Protein of unknown function (DUF454)
SIR_RS14465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SIR_RS14470	COG5002	protein histidine kinase activity
SIR_RS14475	COG0745	RESPONSE REGULATOR receiver
SIR_RS14485	COG0438	transferase activity, transferring glycosyl groups
SIR_RS14495	COG1609	Transcriptional regulator
SIR_RS14500	COG0006	proline dipeptidase activity
SIR_RS14505	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SIR_RS14510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SIR_RS14515	COG1088	dTDP-glucose 4,6-dehydratase activity
SIR_RS14525	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SIR_RS14530	COG1051	belongs to the nudix hydrolase family
SIR_RS14535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SIR_RS14540	COG2384	SAM-dependent methyltransferase
SIR_RS14545	COG1368	sulfuric ester hydrolase activity
SIR_RS14585	COG1442	glycosyl transferase family 8
SIR_RS14585	COG1216	Glycosyl transferase, family 2
SIR_RS14600	COG0463	Glycosyl transferase, family 2
SIR_RS14605	COG1442	glycosyl transferase family 8
SIR_RS14615	COG1091	dTDP-4-dehydrorhamnose reductase activity
SIR_RS14625	COG0463	Glycosyl transferase, family 2
SIR_RS14650	COG1131	(ABC) transporter
SIR_RS14695	COG3340	Belongs to the peptidase S51 family
SIR_RS14715	COG3843	relaxase mobilization nuclease domain protein
SIR_RS14755	COG0551	DNA topoisomerase type I activity
SIR_RS14755	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SIR_RS14825	COG1484	DNA-dependent DNA replication
SIR_RS14840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SIR_RS14850	COG0077	Prephenate dehydratase
SIR_RS14860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SIR_RS14865	COG3679	Belongs to the UPF0342 family
SIR_RS14870	COG0287	Prephenate dehydrogenase
SIR_RS14880	COG0730	response to heat
SIR_RS14885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SIR_RS14890	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SIR_RS14895	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SIR_RS14900	COG0710	3-dehydroquinate dehydratase activity
SIR_RS14905	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SIR_RS14910	COG1368	sulfuric ester hydrolase activity
SIR_RS14930	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SIR_RS14935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SIR_RS14960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SIR_RS14970	COG1191	sigma factor activity
SIR_RS14975	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SIR_RS14980	COG0772	Belongs to the SEDS family
SIR_RS14995	COG1125	glycine betaine transport
SIR_RS15000	COG1174	glycine betaine transport
SIR_RS15010	COG1573	uracil-dna glycosylase
SIR_RS15020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIR_RS15030	COG0322	excinuclease ABC activity
SIR_RS15035	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SIR_RS15045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SIR_RS15060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SIR_RS15085	COG0204	Acyl-transferase
SIR_RS15090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SIR_RS15100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SIR_RS15105	COG0406	alpha-ribazole phosphatase activity
SIR_RS15110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SIR_RS15150	COG4753	response regulator
SIR_RS15150	COG2207	Transcriptional regulator
SIR_RS15155	COG2972	Histidine kinase
SIR_RS15165	COG1653	transport
SIR_RS15170	COG0395	ABC-type sugar transport system, permease component
SIR_RS15175	COG4209	transmembrane transport
SIR_RS15190	COG0383	alpha-mannosidase activity
SIR_RS15200	COG3537	Alpha-1,2-mannosidase
SIR_RS15250	COG1882	Formate acetyltransferase
SIR_RS15255	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SIR_RS15265	COG1447	Phosphotransferase system cellobiose-specific component IIA
SIR_RS15275	COG1349	DNA-binding transcription factor activity
SIR_RS15280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SIR_RS15300	COG1309	transcriptional regulator
SIR_RS15315	COG3850	Histidine kinase
SIR_RS15315	COG5002	protein histidine kinase activity
SIR_RS15320	COG0745	RESPONSE REGULATOR receiver
SIR_RS15325	COG2706	6-phosphogluconolactonase activity
SIR_RS15330	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SIR_RS15335	COG0187	DNA topoisomerase II activity
SIR_RS15345	COG0693	protein deglycase activity
SIR_RS15350	COG0772	Belongs to the SEDS family
SIR_RS15360	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SIR_RS15360	COG1199	ATP-dependent helicase activity
SIR_RS15370	COG2177	Part of the ABC transporter FtsEX involved in
SIR_RS15375	COG2884	Cell division ATP-binding protein ftsE
SIR_RS15380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SIR_RS15400	COG1078	dGTPase activity
SIR_RS15420	COG1132	(ABC) transporter
SIR_RS15425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SIR_RS15435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SIR_RS15440	COG4122	O-methyltransferase activity
SIR_RS15455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SIR_RS15465	COG1447	Phosphotransferase system cellobiose-specific component IIA
SIR_RS15470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SIR_RS15470	COG3711	transcriptional antiterminator
SIR_RS15480	COG4095	Psort location CytoplasmicMembrane, score
SIR_RS15485	COG2723	6-phospho-beta-galactosidase activity
SIR_RS15500	COG0363	glucosamine-6-phosphate deaminase activity
SIR_RS15505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SIR_RS15510	COG1438	arginine binding
SIR_RS15515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIR_RS15520	COG1288	antiporter activity
SIR_RS15525	COG0549	Belongs to the carbamate kinase family
SIR_RS15530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SIR_RS15610	COG3290	protein histidine kinase activity
SIR_RS15620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SIR_RS15625	COG2274	protein secretion by the type I secretion system
SIR_RS15635	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SIR_RS15645	COG2996	Protein conserved in bacteria
SIR_RS15650	COG0233	cytoplasmic translational termination
SIR_RS15655	COG0528	UMP kinase activity
SIR_RS15660	COG0081	regulation of translation
SIR_RS15665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SIR_RS15675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SIR_RS15680	COG0697	spore germination
SIR_RS15680	COG1674	ftsk spoiiie
SIR_RS15685	COG1983	PspC domain protein
SIR_RS15705	COG0488	(ABC) transporter
SIR_RS15715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SIR_RS15730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SIR_RS15755	COG1028	Short-chain dehydrogenase reductase Sdr
SIR_RS15785	COG0531	amino acid
SIR_RS15790	COG0577	efflux transmembrane transporter activity
SIR_RS15795	COG1136	(ABC) transporter
SIR_RS15810	COG3279	Response regulator of the LytR AlgR family
SIR_RS15825	COG0577	efflux transmembrane transporter activity
SIR_RS15830	COG1136	(ABC) transporter
SIR_RS15845	COG0745	RESPONSE REGULATOR receiver
SIR_RS15855	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIR_RS15855	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIR_RS15880	COG0640	Transcriptional regulator
SIR_RS15895	COG0708	Exodeoxyribonuclease III
SIR_RS15905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SIR_RS15910	COG1393	Belongs to the ArsC family
SIR_RS15915	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SIR_RS15925	COG4467	Involved in initiation control of chromosome replication
SIR_RS15930	COG0470	DNA polymerase III
SIR_RS15935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SIR_RS15940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SIR_RS15945	COG0517	IMP dehydrogenase activity
SIR_RS15965	COG0559	Belongs to the binding-protein-dependent transport system permease family
SIR_RS15975	COG4471	UPF0298 protein
SIR_RS15980	COG0740	serine-type endopeptidase activity
SIR_RS15985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SIR_RS15990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SIR_RS15995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SIR_RS16000	COG2244	polysaccharide biosynthetic process
SIR_RS16005	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SIR_RS16030	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SIR_RS16040	COG0366	Alpha amylase catalytic
SIR_RS16045	COG1263	PTS System
SIR_RS16045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SIR_RS16050	COG2188	Transcriptional regulator
SIR_RS16055	COG1253	flavin adenine dinucleotide binding
SIR_RS16065	COG0628	permease
SIR_RS16070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SIR_RS16075	COG3599	regulation of cell shape
SIR_RS16090	COG1799	cell septum assembly
SIR_RS16095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SIR_RS16110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SIR_RS16115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SIR_RS16120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SIR_RS16130	COG1217	gtp-binding protein TYPA
SIR_RS16135	COG1187	pseudouridine synthase activity
SIR_RS16155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SIR_RS16165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SIR_RS16170	COG4470	Protein conserved in bacteria
SIR_RS16175	COG3480	Lon protease (S16) C-terminal proteolytic domain
SIR_RS16180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SIR_RS16185	COG0742	ribosomal rna small subunit methyltransferase
SIR_RS16195	COG1040	competence protein
SIR_RS16200	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SIR_RS16205	COG1739	Uncharacterized protein family UPF0029
SIR_RS16240	COG0525	valine-tRNA ligase activity
SIR_RS16250	COG0519	Catalyzes the synthesis of GMP from XMP
SIR_RS16280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SIR_RS16285	COG3231	kanamycin kinase activity
SIR_RS16290	COG2137	regulation of response to DNA damage stimulus
SIR_RS16295	COG3557	Belongs to the UPF0374 family
SIR_RS16305	COG1185	polyribonucleotide nucleotidyltransferase activity
SIR_RS16320	COG4585	Histidine kinase
SIR_RS16330	COG2815	serine threonine protein kinase
SIR_RS16330	COG0515	serine threonine protein kinase
SIR_RS16335	COG0631	protein serine/threonine phosphatase activity
SIR_RS16340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SIR_RS16340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SIR_RS16345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SIR_RS16350	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SIR_RS16355	COG1758	RNA polymerase activity
SIR_RS16360	COG0194	GDP metabolic process
SIR_RS16365	COG1418	mRNA catabolic process
SIR_RS16415	COG0535	radical SAM domain protein
SIR_RS16435	COG1131	(ABC) transporter
SIR_RS16440	COG0535	radical SAM domain protein
SIR_RS16455	COG3843	relaxase mobilization nuclease domain protein
SIR_RS16475	COG0551	DNA topoisomerase type I activity
SIR_RS16475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SIR_RS16490	COG0791	NLP P60 protein
SIR_RS16490	COG1388	LysM domain
SIR_RS16490	COG3103	Sh3 type 3 domain protein
SIR_RS16545	COG1484	DNA-dependent DNA replication
SIR_RS16560	COG3634	alkyl hydroperoxide reductase activity
SIR_RS16565	COG0450	alkyl hydroperoxide reductase
SIR_RS16575	COG0116	Belongs to the methyltransferase superfamily
SIR_RS16580	COG3599	regulation of cell shape
SIR_RS16585	COG4474	Belongs to the UPF0398 family
SIR_RS16590	COG3331	DNA recombination
SIR_RS16595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SIR_RS16600	COG3579	cysteine-type endopeptidase activity
SIR_RS16605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SIR_RS16610	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SIR_RS16625	COG1113	amino acid transport
SIR_RS16630	COG0492	ferredoxin-NADP+ reductase activity
SIR_RS16640	COG1126	abc transporter atp-binding protein
SIR_RS16650	COG0513	Belongs to the DEAD box helicase family
SIR_RS16655	COG1686	Belongs to the peptidase S11 family
SIR_RS16665	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SIR_RS16670	COG0719	Fe-S assembly protein
SIR_RS16680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SIR_RS16685	COG4862	establishment of competence for transformation
SIR_RS16690	COG1968	undecaprenyl-diphosphatase activity
SIR_RS16700	COG0765	amino acid transport
SIR_RS16705	COG1126	abc transporter atp-binding protein
SIR_RS16720	COG2197	response regulator
SIR_RS16725	COG4585	Histidine kinase
SIR_RS16735	COG1131	(ABC) transporter
SIR_RS16740	COG1461	Dihydroxyacetone kinase
SIR_RS16750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SIR_RS16770	COG0191	fructose-bisphosphate aldolase activity
SIR_RS16785	COG0504	CTP synthase activity
SIR_RS16795	COG4166	transmembrane transport
SIR_RS16800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SIR_RS16805	COG0768	penicillin binding
SIR_RS16830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SIR_RS16845	COG0751	glycine-tRNA ligase activity
SIR_RS16850	COG0752	glycyl-tRNA synthetase alpha subunit
SIR_RS16855	COG1673	EVE domain
SIR_RS16880	COG1283	sodium-dependent phosphate transmembrane transporter activity
SIR_RS16885	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SIR_RS16900	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SIR_RS16905	COG0195	Participates in both transcription termination and antitermination
SIR_RS16910	COG0779	Required for maturation of 30S ribosomal subunits
SIR_RS16920	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SIR_RS16925	COG0510	thiamine kinase activity
SIR_RS16935	COG1131	(ABC) transporter
SIR_RS16940	COG0537	adenosine 5'-monophosphoramidase activity
SIR_RS16950	COG1316	TRANSCRIPTIONal
SIR_RS16960	COG0802	atpase or kinase
SIR_RS16965	COG2252	PERMEase
SIR_RS16975	COG0561	phosphatase activity
SIR_RS16980	COG1064	alcohol dehydrogenase
SIR_RS16990	COG3715	PTS system
SIR_RS16995	COG3716	PTS system mannose fructose sorbose family IID component
SIR_RS17010	COG0586	Pfam SNARE associated Golgi protein
SIR_RS17015	COG0825	malonyl-CoA metabolic process
SIR_RS17020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SIR_RS17025	COG0439	Biotin carboxylase
SIR_RS17030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SIR_RS17040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SIR_RS17045	COG1028	Short-chain dehydrogenase reductase Sdr
SIR_RS17050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SIR_RS17055	COG2070	2-Nitropropane dioxygenase
SIR_RS17065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SIR_RS17075	COG1024	Enoyl-CoA hydratase
SIR_RS17080	COG0527	aspartate kinase activity
SIR_RS17115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SIR_RS17120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SIR_RS17125	COG1464	Belongs to the NlpA lipoprotein family
SIR_RS17130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SIR_RS17145	COG1323	Belongs to the UPF0348 family
SIR_RS17150	COG2226	methyltransferase
SIR_RS17160	COG0799	negative regulation of ribosome biogenesis
SIR_RS17170	COG1713	HD superfamily hydrolase involved in NAD metabolism
SIR_RS17175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SIR_RS17180	COG1534	Rna-binding protein
SIR_RS17185	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SIR_RS17190	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SIR_RS17205	COG1063	alcohol dehydrogenase
SIR_RS17210	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SIR_RS17215	COG0154	amidase activity
SIR_RS17220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SIR_RS17225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SIR_RS17230	COG1335	isochorismatase
SIR_RS17235	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SIR_RS17240	COG0436	Aminotransferase
SIR_RS17245	COG0589	response to stress
SIR_RS17250	COG0561	phosphatase activity
SIR_RS17255	COG0252	asparaginase activity
SIR_RS17265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SIR_RS17270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SIR_RS17275	COG0736	holo-[acyl-carrier-protein] synthase activity
SIR_RS17280	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SIR_RS17290	COG0531	amino acid
SIR_RS17330	COG1482	cell wall glycoprotein biosynthetic process
SIR_RS17335	COG2188	Transcriptional regulator
SIR_RS17340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SIR_RS17345	COG2723	6-phospho-beta-galactosidase activity
SIR_RS17355	COG1132	(ABC) transporter
SIR_RS17370	COG1902	pentaerythritol trinitrate reductase activity
SIR_RS17375	COG0242	peptide deformylase activity
SIR_RS17380	COG1940	carbohydrate kinase activity
SIR_RS17385	COG1263	PTS System
SIR_RS17385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SIR_RS17385	COG2190	(PTS) system
SIR_RS17390	COG1621	beta-fructofuranosidase activity
SIR_RS17395	COG1609	Transcriptional regulator
SIR_RS17400	COG0561	phosphatase activity
SIR_RS17405	COG4608	Belongs to the ABC transporter superfamily
SIR_RS17410	COG0444	Belongs to the ABC transporter superfamily
SIR_RS17415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SIR_RS17420	COG0601	transmembrane transport
SIR_RS17425	COG4166	transmembrane transport
SIR_RS17430	COG4166	transmembrane transport
SIR_RS17440	COG0504	CTP synthase activity
SIR_RS17445	COG3343	RNA polymerase activity
SIR_RS17450	COG0544	peptidyl-prolyl cis-trans isomerase activity
SIR_RS17455	COG4475	Protein of unknown function (DUF436)
SIR_RS17460	COG4720	Psort location CytoplasmicMembrane, score
SIR_RS17465	COG0351	phosphomethylpyrimidine kinase
SIR_RS17470	COG0101	tRNA pseudouridine synthase activity
SIR_RS17480	COG0484	heat shock protein binding
SIR_RS17485	COG0443	Heat shock 70 kDa protein
SIR_RS17490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SIR_RS17495	COG1420	regulation of RNA biosynthetic process
SIR_RS17535	COG2848	UPF0210 protein
SIR_RS17540	COG3830	Belongs to the UPF0237 family
SIR_RS17545	COG1609	Transcriptional regulator
SIR_RS17560	COG3716	PTS system mannose fructose sorbose family IID component
SIR_RS17565	COG3715	PTS system
SIR_RS17570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SIR_RS17575	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SIR_RS17585	COG1028	Short-chain dehydrogenase reductase Sdr
SIR_RS17610	COG5492	domain, Protein
SIR_RS17615	COG0386	Belongs to the glutathione peroxidase family
SIR_RS17650	COG1131	(ABC) transporter
SIR_RS17685	COG2217	Heavy metal translocating P-type atpase
SIR_RS17695	COG3328	transposase activity
SIR_RS17710	COG2184	nucleotidyltransferase activity
SIR_RS17715	COG1132	(ABC) transporter
SIR_RS17745	COG2946	Replication initiation factor
SIR_RS17760	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SIR_RS17765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SIR_RS17780	COG3842	ATPase activity
SIR_RS17790	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SIR_RS17795	COG0215	cysteine-tRNA ligase activity
SIR_RS17805	COG1045	serine acetyltransferase
SIR_RS17810	COG1185	polyribonucleotide nucleotidyltransferase activity
SIR_RS17815	COG1164	Oligoendopeptidase f
SIR_RS17830	COG1187	pseudouridine synthase activity
SIR_RS17895	COG2309	aminopeptidase activity
SIR_RS17905	COG2176	DNA-directed DNA polymerase activity
SIR_RS17910	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SIR_RS17915	COG1523	belongs to the glycosyl hydrolase 13 family
SIR_RS17925	COG3590	peptidase
SIR_RS17960	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SIR_RS17985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SIR_RS17995	COG0561	phosphatase activity
SIR_RS18000	COG1609	Transcriptional regulator
SIR_RS18015	COG0459	protein refolding
SIR_RS18030	COG3716	PTS system mannose fructose sorbose family IID component
SIR_RS18035	COG3715	PTS system
SIR_RS18055	COG2197	response regulator
SIR_RS18060	COG4585	Histidine kinase
SIR_RS18075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SIR_RS18080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SIR_RS18090	COG1363	Peptidase, m42
SIR_RS18100	COG0285	dihydrofolate synthase activity
SIR_RS18110	COG0442	prolyl-tRNA aminoacylation
SIR_RS18115	COG0750	zinc metalloprotease
SIR_RS18120	COG4589	Belongs to the CDS family
SIR_RS18125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SIR_RS18140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SIR_RS18170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SIR_RS18180	COG3037	sugar-specific permease SgaT UlaA
SIR_RS18195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SIR_RS18225	COG4537	Required for transformation and DNA binding
SIR_RS18230	COG1459	type II secretion system
SIR_RS18235	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SIR_RS18245	COG0174	glutamine synthetase
SIR_RS18250	COG0789	Transcriptional regulator
SIR_RS18260	COG3942	CHAP domain
SIR_RS18270	COG0126	phosphoglycerate kinase activity
SIR_RS18275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SIR_RS18280	COG0085	RNA polymerase activity
SIR_RS18285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SIR_RS18285	COG4499	WXG100 protein secretion system (Wss), protein YukC
SIR_RS18295	COG0500	methyltransferase
SIR_RS18305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SIR_RS18310	COG1473	amidohydrolase
SIR_RS18315	COG2171	N-acyltransferase activity
SIR_RS18320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SIR_RS18335	COG0756	dUTP diphosphatase activity
SIR_RS18350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SIR_RS18355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SIR_RS18390	COG1396	sequence-specific DNA binding
SIR_RS18395	COG1881	PFAM PEBP family protein
SIR_RS18430	COG1674	ftsk spoiiie
SIR_RS18475	COG0433	COG0433 Predicted ATPase
SIR_RS18490	COG3942	CHAP domain
SIR_RS18490	COG1705	Flagellar rod assembly protein muramidase FlgJ
SIR_RS18600	COG0203	ribosomal protein L17
SIR_RS18605	COG0202	RNA polymerase activity
SIR_RS18610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SIR_RS18615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SIR_RS18620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SIR_RS18625	COG0563	adenylate kinase activity
SIR_RS18630	COG0201	protein transport
SIR_RS18635	COG0200	Binds to the 23S rRNA
SIR_RS18640	COG1841	ribosomal large subunit assembly
SIR_RS18645	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SIR_RS18655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SIR_RS18660	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SIR_RS18665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SIR_RS18670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SIR_RS18675	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SIR_RS18680	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SIR_RS18685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SIR_RS18690	COG0255	Belongs to the universal ribosomal protein uL29 family
SIR_RS18695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SIR_RS18700	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SIR_RS18705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SIR_RS18715	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SIR_RS18720	COG0089	rRNA binding
SIR_RS18725	COG0088	Forms part of the polypeptide exit tunnel
SIR_RS18730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SIR_RS18735	COG0051	transcription antitermination factor activity, RNA binding
SIR_RS18745	COG0343	queuine tRNA-ribosyltransferase activity
SIR_RS18760	COG1832	CoA-binding protein
SIR_RS18765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIR_RS18765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SIR_RS18795	COG5002	protein histidine kinase activity
SIR_RS18820	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SIR_RS18830	COG1216	Glycosyl transferase, family 2
SIR_RS18840	COG1216	Glycosyl transferase, family 2
SIR_RS18845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SIR_RS18850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SIR_RS18865	COG3944	biosynthesis protein
SIR_RS18870	COG4464	protein tyrosine phosphatase activity
SIR_RS18880	COG0602	queuosine metabolic process
SIR_RS18905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SIR_RS18925	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SIR_RS18930	COG4472	Bacterial protein of unknown function (DUF965)
SIR_RS18945	COG1393	Belongs to the ArsC family
SIR_RS18950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SIR_RS18955	COG1546	Belongs to the CinA family
SIR_RS18955	COG1058	Belongs to the CinA family
SIR_RS18965	COG1266	CAAX protease self-immunity
SIR_RS18970	COG2818	Glycosylase
SIR_RS18975	COG0632	four-way junction helicase activity
SIR_RS18980	COG1395	domain, Protein
SIR_RS18990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SIR_RS19005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SIR_RS19010	COG1438	arginine binding
SIR_RS19015	COG0018	arginyl-trna synthetase
SIR_RS19020	COG1780	Probably involved in ribonucleotide reductase function
SIR_RS19030	COG0058	SHG alpha-glucan phosphorylase activity
SIR_RS19035	COG1640	4-alpha-glucanotransferase
SIR_RS19045	COG2182	Extracellular solute-binding protein
SIR_RS19050	COG1175	transmembrane transport
SIR_RS19055	COG3833	ABC-type maltose transport systems, permease component
SIR_RS19060	COG5521	maltodextrose utilization protein MalA
SIR_RS19065	COG1609	Transcriptional regulator
SIR_RS19070	COG1523	belongs to the glycosyl hydrolase 13 family
SIR_RS19075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SIR_RS19090	COG0124	histidyl-tRNA synthetase
SIR_RS19095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SIR_RS19100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SIR_RS19150	COG4974	Belongs to the 'phage' integrase family
SIR_RS19165	COG1396	sequence-specific DNA binding
SIR_RS19170	COG2217	Heavy metal translocating P-type atpase
SIR_RS19175	COG2807	transmembrane transport
SIR_RS19180	COG2094	Belongs to the DNA glycosylase MPG family
SIR_RS19190	COG0561	phosphatase activity
SIR_RS19200	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SIR_RS19205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SIR_RS19210	COG1696	Membrane protein involved in D-alanine export
SIR_RS19285	COG0561	phosphatase activity
SIR_RS19300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SIR_RS19305	COG1011	Hydrolase
SIR_RS19315	COG0305	Participates in initiation and elongation during chromosome replication
SIR_RS19330	COG0445	tRNA wobble uridine modification
SIR_RS19335	COG0482	sulfurtransferase activity
SIR_RS19345	COG1760	l-serine dehydratase
SIR_RS19350	COG1760	l-serine dehydratase
SIR_RS19360	COG0741	lytic transglycosylase activity
SIR_RS19365	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SIR_RS19370	COG1122	ATPase activity
SIR_RS19375	COG1122	ATPase activity
SIR_RS19380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SIR_RS19390	COG0612	Peptidase, M16
SIR_RS19395	COG0612	Peptidase, M16
SIR_RS19405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SIR_RS19410	COG0517	IMP dehydrogenase activity
SIR_RS19410	COG0516	GMP reductase activity
SIR_RS19415	COG0180	Tryptophanyl-tRNA synthetase
SIR_RS19420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SIR_RS19425	COG0149	triose-phosphate isomerase activity
SIR_RS19435	COG0488	(ABC) transporter
SIR_RS19460	COG4191	Histidine kinase
SIR_RS19475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SIR_RS19480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SIR_RS19485	COG1475	DNA binding
SIR_RS19550	COG3475	LICD family