locus-tag	class	description
SII_RS00010	COG0592	DNA-directed DNA polymerase activity
SII_RS00025	COG0012	GTP binding
SII_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
SII_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SII_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SII_RS00055	COG0037	tRNA processing
SII_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SII_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SII_RS00185	COG1792	Involved in formation and maintenance of cell shape
SII_RS00195	COG3942	CHAP domain
SII_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SII_RS00205	COG0436	Aminotransferase
SII_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
SII_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SII_RS00225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SII_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SII_RS00240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SII_RS00245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SII_RS00250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SII_RS00260	COG0138	bifunctional purine biosynthesis protein purh
SII_RS00265	COG3942	CHAP domain
SII_RS00275	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SII_RS00300	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SII_RS00305	COG2376	Dihydroxyacetone kinase
SII_RS00315	COG2376	Dihydroxyacetone kinase
SII_RS00320	COG1461	Dihydroxyacetone kinase
SII_RS00325	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SII_RS00330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SII_RS00345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SII_RS00355	COG3716	PTS system mannose fructose sorbose family IID component
SII_RS00365	COG2222	sugar isomerase
SII_RS00385	COG2255	four-way junction helicase activity
SII_RS00425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SII_RS00440	COG1454	alcohol dehydrogenase
SII_RS00440	COG1012	belongs to the aldehyde dehydrogenase family
SII_RS00445	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SII_RS00455	COG1175	transmembrane transport
SII_RS00460	COG0395	ABC-type sugar transport system, permease component
SII_RS00465	COG2731	YhcH YjgK YiaL family protein
SII_RS00475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SII_RS00495	COG1263	PTS System
SII_RS00495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SII_RS00500	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SII_RS00515	COG1269	ATP hydrolysis coupled proton transport
SII_RS00520	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SII_RS00530	COG1527	subunit (C
SII_RS00540	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SII_RS00545	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SII_RS00550	COG1394	ATPase activity, coupled to movement of substances
SII_RS00580	COG1388	LysM domain
SII_RS00580	COG4932	domain protein
SII_RS00595	COG1846	Transcriptional regulator
SII_RS00600	COG1121	(ABC) transporter
SII_RS00605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SII_RS00610	COG3443	Belongs to the bacterial solute-binding protein 9 family
SII_RS00610	COG0803	Belongs to the bacterial solute-binding protein 9 family
SII_RS00630	COG0564	pseudouridine synthase activity
SII_RS00635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SII_RS00660	COG0052	Belongs to the universal ribosomal protein uS2 family
SII_RS00665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SII_RS00675	COG4463	regulation of RNA biosynthetic process
SII_RS00690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SII_RS00695	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SII_RS00725	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SII_RS00760	COG0166	Belongs to the GPI family
SII_RS00770	COG0594	ribonuclease P activity
SII_RS00795	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SII_RS00800	COG0084	hydrolase, TatD family'
SII_RS00810	COG4842	Belongs to the WXG100 family
SII_RS00860	COG4499	WXG100 protein secretion system (Wss), protein YukC
SII_RS00865	COG1674	ftsk spoiiie
SII_RS00955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SII_RS00980	COG1564	THIamine pyrophosphokinase
SII_RS00990	COG3481	metal-dependent phosphohydrolase, HD sub domain
SII_RS00995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SII_RS01000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SII_RS01005	COG0049	tRNA binding
SII_RS01010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SII_RS01030	COG1214	PFAM Peptidase M22, glycoprotease
SII_RS01040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SII_RS01055	COG1396	sequence-specific DNA binding
SII_RS01075	COG0789	Transcriptional regulator
SII_RS01085	COG2081	HI0933 family
SII_RS01100	COG0584	glycerophosphoryl diester phosphodiesterase
SII_RS01105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SII_RS01110	COG2936	dipeptidyl-peptidase activity
SII_RS01115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SII_RS01150	COG1304	FMN binding
SII_RS01160	COG3425	synthase
SII_RS01175	COG1882	Formate acetyltransferase
SII_RS01180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SII_RS01185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SII_RS01190	COG0681	Belongs to the peptidase S26 family
SII_RS01210	COG1193	negative regulation of DNA recombination
SII_RS01220	COG3118	belongs to the thioredoxin family
SII_RS01225	COG0531	amino acid
SII_RS01230	COG0668	transmembrane transport
SII_RS01235	COG5504	Zn-dependent protease
SII_RS01245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SII_RS01250	COG0167	dihydroorotate dehydrogenase activity
SII_RS01255	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SII_RS01255	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SII_RS01260	COG0402	S-adenosylhomocysteine deaminase activity
SII_RS01265	COG1136	(ABC) transporter
SII_RS01270	COG1940	carbohydrate kinase activity
SII_RS01275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SII_RS01290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SII_RS01295	COG1447	Phosphotransferase system cellobiose-specific component IIA
SII_RS01300	COG1309	transcriptional regulator
SII_RS01325	COG0346	lactoylglutathione lyase activity
SII_RS01340	COG1401	restriction endodeoxyribonuclease activity
SII_RS01360	COG0745	RESPONSE REGULATOR receiver
SII_RS01365	COG5002	protein histidine kinase activity
SII_RS01380	COG0366	Alpha amylase catalytic
SII_RS01390	COG1122	ATPase activity
SII_RS01400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SII_RS01410	COG2134	cdp-diacylglycerol pyrophosphatase
SII_RS01485	COG0629	single-stranded DNA binding
SII_RS01490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SII_RS01510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SII_RS01520	COG0006	proline dipeptidase activity
SII_RS01525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SII_RS01625	COG4720	Psort location CytoplasmicMembrane, score
SII_RS01655	COG1122	ATPase activity
SII_RS01665	COG4221	oxidoreductase activity
SII_RS01670	COG1442	glycosyl transferase family 8
SII_RS01680	COG0357	Ribosomal RNA small subunit methyltransferase G
SII_RS01685	COG1704	LemA family
SII_RS01690	COG0501	Belongs to the peptidase M48B family
SII_RS01705	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SII_RS01710	COG0745	RESPONSE REGULATOR receiver
SII_RS01715	COG2190	(PTS) system
SII_RS01715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SII_RS01715	COG1263	PTS System
SII_RS01720	COG1263	PTS System
SII_RS01720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SII_RS01720	COG2190	(PTS) system
SII_RS01735	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SII_RS01745	COG1484	DNA-dependent DNA replication
SII_RS01755	COG1160	GTP binding
SII_RS01760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SII_RS01770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SII_RS01785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SII_RS01805	COG1254	Belongs to the acylphosphatase family
SII_RS01810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SII_RS01835	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SII_RS01840	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SII_RS01850	COG0517	IMP dehydrogenase activity
SII_RS01855	COG4974	Belongs to the 'phage' integrase family
SII_RS01860	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SII_RS01870	COG1187	pseudouridine synthase activity
SII_RS01880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SII_RS01885	COG0569	domain protein
SII_RS01895	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SII_RS01900	COG0671	phosphoesterase, PA-phosphatase related
SII_RS01910	COG1242	4 iron, 4 sulfur cluster binding
SII_RS01915	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SII_RS01925	COG0025	NhaP-type Na H and K H
SII_RS01935	COG0494	nUDIX hydrolase
SII_RS01940	COG2378	regulation of single-species biofilm formation
SII_RS01950	COG0542	response to heat
SII_RS01955	COG4703	Protein of unknown function (DUF1797)
SII_RS01985	COG1136	(ABC) transporter
SII_RS01990	COG0577	efflux transmembrane transporter activity
SII_RS01995	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SII_RS02000	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SII_RS02005	COG1570	exodeoxyribonuclease VII activity
SII_RS02010	COG1722	exodeoxyribonuclease VII activity
SII_RS02015	COG0142	geranyltranstransferase activity
SII_RS02020	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SII_RS02025	COG1438	arginine binding
SII_RS02030	COG0497	DNA recombination
SII_RS02045	COG4604	ABC transporter, ATP-binding protein
SII_RS02050	COG4605	iron ion homeostasis
SII_RS02055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SII_RS02060	COG1307	EDD domain protein, DegV family
SII_RS02070	COG0735	belongs to the Fur family
SII_RS02075	COG0588	phosphoglycerate mutase activity
SII_RS02080	COG0768	penicillin binding
SII_RS02085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SII_RS02090	COG1181	Belongs to the D-alanine--D-alanine ligase family
SII_RS02095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SII_RS02115	COG3620	sequence-specific DNA binding
SII_RS02125	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SII_RS02140	COG0513	Belongs to the DEAD box helicase family
SII_RS02155	COG0698	ribose 5-phosphate isomerase
SII_RS02175	COG3775	system Galactitol-specific IIC component
SII_RS02180	COG1105	Belongs to the carbohydrate kinase PfkB family
SII_RS02185	COG3583	domain protein
SII_RS02185	COG3064	Membrane
SII_RS02185	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SII_RS02190	COG3711	transcriptional antiterminator
SII_RS02195	COG1447	Phosphotransferase system cellobiose-specific component IIA
SII_RS02200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SII_RS02200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SII_RS02205	COG2723	6-phospho-beta-galactosidase activity
SII_RS02210	COG1755	Isoprenylcysteine carboxyl methyltransferase
SII_RS02215	COG2827	Endonuclease containing a URI domain
SII_RS02220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SII_RS02225	COG0254	rRNA binding
SII_RS02230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SII_RS02235	COG0716	FMN binding
SII_RS02245	COG0628	permease
SII_RS02255	COG0028	Belongs to the TPP enzyme family
SII_RS02260	COG3527	Alpha-acetolactate decarboxylase
SII_RS02265	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SII_RS02280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SII_RS02290	COG4443	Transcriptional Coactivator p15 (PC4)
SII_RS02325	COG4152	abc transporter atp-binding protein
SII_RS02330	COG1668	transmembrane transport
SII_RS02335	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SII_RS02340	COG1074	ATP-dependent DNA helicase activity
SII_RS02345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SII_RS02360	COG0297	glycogen (starch) synthase activity
SII_RS02365	COG0058	SHG alpha-glucan phosphorylase activity
SII_RS02375	COG0356	it plays a direct role in the translocation of protons across the membrane
SII_RS02380	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SII_RS02385	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SII_RS02390	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SII_RS02395	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SII_RS02410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SII_RS02430	COG1132	(ABC) transporter
SII_RS02450	COG1346	cytolysis
SII_RS02455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SII_RS02475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SII_RS02480	COG0492	ferredoxin-NADP+ reductase activity
SII_RS02490	COG1349	DNA-binding transcription factor activity
SII_RS02495	COG1105	Belongs to the carbohydrate kinase PfkB family
SII_RS02500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SII_RS02500	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SII_RS02500	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SII_RS02510	COG1307	EDD domain protein, DegV family
SII_RS02515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SII_RS02520	COG0617	tRNA 3'-terminal CCA addition
SII_RS02525	COG0488	(ABC) transporter
SII_RS02540	COG0072	phenylalanine-tRNA ligase activity
SII_RS02540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SII_RS02545	COG1268	BioY protein
SII_RS02550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SII_RS02560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SII_RS02565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SII_RS02585	COG0300	oxidoreductase activity
SII_RS02600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SII_RS02600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SII_RS02605	COG1131	(ABC) transporter
SII_RS02620	COG0205	6-phosphofructokinase activity
SII_RS02625	COG0469	pyruvate kinase activity
SII_RS02640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SII_RS02645	COG0210	DNA helicase
SII_RS02650	COG0494	nUDIX hydrolase
SII_RS02660	COG1132	(ABC) transporter
SII_RS02660	COG2375	cellular response to nickel ion
SII_RS02665	COG1132	(ABC) transporter
SII_RS02690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SII_RS02695	COG0196	riboflavin kinase activity
SII_RS02700	COG1393	Belongs to the ArsC family
SII_RS02705	COG4476	Belongs to the UPF0223 family
SII_RS02710	COG0483	inositol monophosphate 1-phosphatase activity
SII_RS02715	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SII_RS02715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SII_RS02725	COG0573	inorganic phosphate transmembrane transporter activity
SII_RS02730	COG0581	inorganic phosphate transmembrane transporter activity
SII_RS02735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SII_RS02740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SII_RS02745	COG0704	Plays a role in the regulation of phosphate uptake
SII_RS02750	COG2003	Belongs to the UPF0758 family
SII_RS02775	COG1104	cysteine desulfurase activity
SII_RS02780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SII_RS02790	COG2357	RelA SpoT domain protein
SII_RS02800	COG0564	pseudouridine synthase activity
SII_RS02805	COG0280	phosphate acetyltransferase
SII_RS02810	COG1194	a g-specific adenine glycosylase
SII_RS02820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SII_RS02825	COG4684	Psort location CytoplasmicMembrane, score
SII_RS02830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SII_RS02845	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SII_RS02865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SII_RS02870	COG0477	Major facilitator Superfamily
SII_RS02875	COG3689	TIGRFAM TIGR03943 family protein
SII_RS02880	COG0701	Predicted permease
SII_RS02885	COG2183	response to ionizing radiation
SII_RS02890	COG3091	SprT-like family
SII_RS02900	COG1051	belongs to the nudix hydrolase family
SII_RS02905	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SII_RS02910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SII_RS02935	COG0826	peptidase U32
SII_RS02960	COG0488	(ABC) transporter
SII_RS02970	COG3442	glutamine amidotransferase
SII_RS02975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SII_RS02980	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SII_RS02990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SII_RS02995	COG0560	Phosphoserine phosphatase
SII_RS03020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SII_RS03030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SII_RS03040	COG0346	lactoylglutathione lyase activity
SII_RS03045	COG0726	polysaccharide deacetylase
SII_RS03055	COG0673	inositol 2-dehydrogenase activity
SII_RS03060	COG0572	uridine kinase
SII_RS03065	COG2195	Cleaves the N-terminal amino acid of tripeptides
SII_RS03075	COG0561	phosphatase activity
SII_RS03080	COG0481	GTPase activity
SII_RS03085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SII_RS03090	COG3842	ATPase activity
SII_RS03095	COG1176	ABC-type spermidine putrescine transport system, permease component I
SII_RS03100	COG1177	transmembrane transport
SII_RS03110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SII_RS03115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SII_RS03130	COG3708	Transcriptional regulator
SII_RS03130	COG2207	Transcriptional regulator
SII_RS03135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SII_RS03140	COG0222	ribosome binding
SII_RS03155	COG0270	DNA (cytosine-5-)-methyltransferase activity
SII_RS03245	COG1674	ftsk spoiiie
SII_RS03250	COG2946	Replication initiation factor
SII_RS03385	COG1396	sequence-specific DNA binding
SII_RS03390	COG0542	response to heat
SII_RS03395	COG0613	PHP domain protein
SII_RS03410	COG3843	relaxase mobilization nuclease domain protein
SII_RS03415	COG1396	sequence-specific DNA binding
SII_RS03425	COG4974	Belongs to the 'phage' integrase family
SII_RS03440	COG1136	(ABC) transporter
SII_RS03440	COG0577	efflux transmembrane transporter activity
SII_RS03465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SII_RS03470	COG0336	Belongs to the RNA methyltransferase TrmD family
SII_RS03475	COG3443	Belongs to the bacterial solute-binding protein 9 family
SII_RS03475	COG0803	Belongs to the bacterial solute-binding protein 9 family
SII_RS03500	COG3620	sequence-specific DNA binding
SII_RS03510	COG1956	GAF domain-containing protein
SII_RS03515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SII_RS03525	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SII_RS03525	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SII_RS03530	COG1609	Transcriptional regulator
SII_RS03535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SII_RS03545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SII_RS03555	COG0726	polysaccharide deacetylase
SII_RS03565	COG0083	homoserine kinase activity
SII_RS03585	COG2814	Major facilitator Superfamily
SII_RS03595	COG0543	2 iron, 2 sulfur cluster binding
SII_RS03600	COG0167	dihydroorotate dehydrogenase activity
SII_RS03605	COG0284	orotidine-5'-phosphate decarboxylase activity
SII_RS03615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SII_RS03620	COG4479	Belongs to the UPF0346 family
SII_RS03625	COG1702	phosphate starvation-inducible protein PhoH
SII_RS03645	COG0686	Belongs to the AlaDH PNT family
SII_RS03660	COG1132	(ABC) transporter
SII_RS03665	COG1132	(ABC) transporter
SII_RS03675	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SII_RS03700	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SII_RS03705	COG0237	dephospho-CoA kinase activity
SII_RS03710	COG2814	Major facilitator Superfamily
SII_RS03720	COG0557	exoribonuclease II activity
SII_RS03725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SII_RS03735	COG2333	competence protein COMEC
SII_RS03735	COG0658	competence protein
SII_RS03750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SII_RS03755	COG1051	belongs to the nudix hydrolase family
SII_RS03760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SII_RS03765	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SII_RS03770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SII_RS03775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SII_RS03780	COG4109	DRTGG domain
SII_RS03795	COG1846	Transcriptional regulator
SII_RS03810	COG4708	membrane
SII_RS03820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SII_RS03825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SII_RS03830	COG1597	lipid kinase activity
SII_RS03835	COG1523	belongs to the glycosyl hydrolase 13 family
SII_RS03840	COG0228	four-way junction DNA binding
SII_RS03845	COG1837	Belongs to the UPF0109 family
SII_RS03850	COG1827	regulation of RNA biosynthetic process
SII_RS03865	COG3142	Participates in the control of copper homeostasis
SII_RS03870	COG2315	Protein conserved in bacteria
SII_RS03875	COG1132	(ABC) transporter
SII_RS03880	COG1132	(ABC) transporter
SII_RS03885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SII_RS03900	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SII_RS03910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SII_RS03915	COG0110	maltose O-acetyltransferase activity
SII_RS03920	COG0758	DNA mediated transformation
SII_RS03925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SII_RS03930	COG0135	phosphoribosylanthranilate isomerase activity
SII_RS03935	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SII_RS03955	COG4974	Belongs to the 'phage' integrase family
SII_RS04005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SII_RS04015	COG2188	Transcriptional regulator
SII_RS04030	COG0741	lytic transglycosylase activity
SII_RS04040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SII_RS04045	COG0009	L-threonylcarbamoyladenylate synthase
SII_RS04050	COG2890	protein-(glutamine-N5) methyltransferase activity
SII_RS04060	COG1435	thymidine kinase activity
SII_RS04065	COG1942	4-Oxalocrotonate Tautomerase
SII_RS04070	COG0534	Mate efflux family protein
SII_RS04075	COG2233	PERMEase
SII_RS04080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SII_RS04120	COG0431	NADPH-dependent FMN reductase
SII_RS04120	COG1053	succinate dehydrogenase
SII_RS04120	COG3976	FMN-binding domain protein
SII_RS04125	COG4555	ABC transporter
SII_RS04140	COG2972	Histidine kinase
SII_RS04145	COG4753	response regulator
SII_RS04145	COG2207	Transcriptional regulator
SII_RS04150	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SII_RS04150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SII_RS04155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SII_RS04160	COG0785	Cytochrome C biogenesis protein
SII_RS04170	COG2151	metal-sulfur cluster biosynthetic enzyme
SII_RS04175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SII_RS04180	COG0358	DNA primase activity
SII_RS04185	COG1970	mechanosensitive ion channel activity
SII_RS04190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SII_RS04195	COG3764	Sortase (surface protein transpeptidase)
SII_RS04200	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SII_RS04205	COG0039	L-malate dehydrogenase activity
SII_RS04225	COG0539	negative regulation of cytoplasmic translation
SII_RS04245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SII_RS04250	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SII_RS04260	COG0187	DNA topoisomerase II activity
SII_RS04265	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SII_RS04275	COG2131	deaminase
SII_RS04280	COG1309	transcriptional regulator
SII_RS04335	COG2814	Major facilitator Superfamily
SII_RS04340	COG0017	Asparaginyl-tRNA synthetase
SII_RS04350	COG0436	Aminotransferase
SII_RS04360	COG1846	Transcriptional regulator
SII_RS04370	COG3022	response to hydroperoxide
SII_RS04380	COG1272	protein, Hemolysin III
SII_RS04385	COG1079	Belongs to the binding-protein-dependent transport system permease family
SII_RS04390	COG4603	Belongs to the binding-protein-dependent transport system permease family
SII_RS04395	COG3845	ABC transporter
SII_RS04400	COG1744	ABC transporter substrate-binding protein PnrA-like
SII_RS04405	COG0295	cytidine deaminase activity
SII_RS04410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SII_RS04420	COG2813	Specifically methylates the guanine in position
SII_RS04425	COG1072	(Pantothenic acid kinase))
SII_RS04445	COG5002	protein histidine kinase activity
SII_RS04450	COG0745	RESPONSE REGULATOR receiver
SII_RS04475	COG1940	carbohydrate kinase activity
SII_RS04480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SII_RS04485	COG0505	Belongs to the CarA family
SII_RS04490	COG0540	Belongs to the ATCase OTCase family
SII_RS04500	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SII_RS04510	COG1481	regulation of sporulation
SII_RS04515	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SII_RS04520	COG1660	Displays ATPase and GTPase activities
SII_RS04540	COG0647	UMP catabolic process
SII_RS04545	COG1051	belongs to the nudix hydrolase family
SII_RS04555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SII_RS04575	COG0556	nucleotide-excision repair
SII_RS04590	COG0488	(ABC) transporter
SII_RS04595	COG1132	(ABC) transporter
SII_RS04610	COG1388	LysM domain
SII_RS04610	COG1705	Flagellar rod assembly protein muramidase FlgJ
SII_RS04615	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SII_RS04620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SII_RS04630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SII_RS04640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SII_RS04645	COG0038	chloride channel
SII_RS04665	COG2824	Alkylphosphonate utilization operon protein PhnA
SII_RS04675	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SII_RS04680	COG0564	pseudouridine synthase activity
SII_RS04685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SII_RS04690	COG0583	DNA-binding transcription factor activity
SII_RS04705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SII_RS04710	COG0446	pyridine nucleotide-disulphide oxidoreductase
SII_RS04715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SII_RS04725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SII_RS04735	COG0301	tRNA thio-modification
SII_RS04740	COG1104	cysteine desulfurase activity
SII_RS04745	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SII_RS04750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SII_RS04755	COG0517	IMP dehydrogenase activity
SII_RS04760	COG0574	Belongs to the PEP-utilizing enzyme family
SII_RS04760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SII_RS04770	COG0552	protein localization to endoplasmic reticulum
SII_RS04775	COG0561	phosphatase activity
SII_RS04780	COG0561	phosphatase activity
SII_RS04785	COG1196	nuclear chromosome segregation
SII_RS04790	COG0571	ribonuclease III activity
SII_RS04795	COG2832	Protein of unknown function (DUF454)
SII_RS04800	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SII_RS04805	COG5002	protein histidine kinase activity
SII_RS04810	COG0745	RESPONSE REGULATOR receiver
SII_RS04820	COG0438	transferase activity, transferring glycosyl groups
SII_RS04830	COG1609	Transcriptional regulator
SII_RS04835	COG0006	proline dipeptidase activity
SII_RS04840	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SII_RS04845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SII_RS04850	COG1088	dTDP-glucose 4,6-dehydratase activity
SII_RS04860	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SII_RS04865	COG0494	nUDIX hydrolase
SII_RS04870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SII_RS04875	COG2384	SAM-dependent methyltransferase
SII_RS04880	COG1368	sulfuric ester hydrolase activity
SII_RS04910	COG0438	transferase activity, transferring glycosyl groups
SII_RS04920	COG1216	Glycosyl transferase, family 2
SII_RS04920	COG1442	glycosyl transferase family 8
SII_RS04935	COG0463	Glycosyl transferase, family 2
SII_RS04940	COG1442	glycosyl transferase family 8
SII_RS04950	COG1091	dTDP-4-dehydrorhamnose reductase activity
SII_RS04960	COG0463	Glycosyl transferase, family 2
SII_RS04985	COG1131	(ABC) transporter
SII_RS05070	COG0842	Transport permease protein
SII_RS05070	COG1129	ABC transporter
SII_RS05075	COG1725	Transcriptional regulator
SII_RS05090	COG5290	Psort location Cytoplasmic, score
SII_RS05120	COG0551	DNA topoisomerase type I activity
SII_RS05120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SII_RS05190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SII_RS05200	COG0077	Prephenate dehydratase
SII_RS05210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SII_RS05215	COG3679	Belongs to the UPF0342 family
SII_RS05220	COG0287	Prephenate dehydrogenase
SII_RS05230	COG0730	response to heat
SII_RS05235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SII_RS05240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SII_RS05245	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SII_RS05250	COG0710	3-dehydroquinate dehydratase activity
SII_RS05255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SII_RS05260	COG1368	sulfuric ester hydrolase activity
SII_RS05280	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SII_RS05285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SII_RS05310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SII_RS05320	COG1191	sigma factor activity
SII_RS05325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SII_RS05330	COG0772	Belongs to the SEDS family
SII_RS05345	COG1125	glycine betaine transport
SII_RS05350	COG1174	glycine betaine transport
SII_RS05360	COG1573	uracil-dna glycosylase
SII_RS05370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SII_RS05380	COG0322	excinuclease ABC activity
SII_RS05385	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SII_RS05395	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SII_RS05435	COG0204	Acyl-transferase
SII_RS05440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SII_RS05450	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SII_RS05455	COG0406	alpha-ribazole phosphatase activity
SII_RS05460	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SII_RS05495	COG2207	Transcriptional regulator
SII_RS05495	COG4753	response regulator
SII_RS05500	COG2972	Histidine kinase
SII_RS05510	COG1653	transport
SII_RS05515	COG0395	ABC-type sugar transport system, permease component
SII_RS05520	COG4209	transmembrane transport
SII_RS05535	COG0383	alpha-mannosidase activity
SII_RS05545	COG3537	Alpha-1,2-mannosidase
SII_RS05595	COG1882	Formate acetyltransferase
SII_RS05600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SII_RS05610	COG1447	Phosphotransferase system cellobiose-specific component IIA
SII_RS05620	COG1349	DNA-binding transcription factor activity
SII_RS05625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SII_RS05640	COG1136	(ABC) transporter
SII_RS05645	COG1309	transcriptional regulator
SII_RS05665	COG0745	RESPONSE REGULATOR receiver
SII_RS05670	COG2706	6-phosphogluconolactonase activity
SII_RS05675	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SII_RS05680	COG0187	DNA topoisomerase II activity
SII_RS05690	COG0693	protein deglycase activity
SII_RS05695	COG0772	Belongs to the SEDS family
SII_RS05705	COG1199	ATP-dependent helicase activity
SII_RS05705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SII_RS05715	COG2177	Part of the ABC transporter FtsEX involved in
SII_RS05720	COG2884	Cell division ATP-binding protein ftsE
SII_RS05725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SII_RS05740	COG1078	dGTPase activity
SII_RS05750	COG2348	transferase activity, transferring amino-acyl groups
SII_RS05760	COG2274	protein secretion by the type I secretion system
SII_RS05765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SII_RS05775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SII_RS05780	COG4122	O-methyltransferase activity
SII_RS05795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SII_RS05805	COG1447	Phosphotransferase system cellobiose-specific component IIA
SII_RS05810	COG3711	transcriptional antiterminator
SII_RS05810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SII_RS05820	COG4095	Psort location CytoplasmicMembrane, score
SII_RS05825	COG2723	6-phospho-beta-galactosidase activity
SII_RS05840	COG0363	glucosamine-6-phosphate deaminase activity
SII_RS05845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SII_RS05850	COG1438	arginine binding
SII_RS05855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SII_RS05860	COG1288	antiporter activity
SII_RS05865	COG0549	Belongs to the carbamate kinase family
SII_RS05870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SII_RS05945	COG3290	protein histidine kinase activity
SII_RS05955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SII_RS05960	COG2274	protein secretion by the type I secretion system
SII_RS05970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SII_RS05985	COG0732	type I restriction modification DNA specificity domain
SII_RS05990	COG0732	type I restriction modification DNA specificity domain
SII_RS06005	COG2996	Protein conserved in bacteria
SII_RS06010	COG0233	cytoplasmic translational termination
SII_RS06015	COG0528	UMP kinase activity
SII_RS06020	COG0081	regulation of translation
SII_RS06025	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SII_RS06035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SII_RS06040	COG0697	spore germination
SII_RS06040	COG1674	ftsk spoiiie
SII_RS06045	COG1983	PspC domain protein
SII_RS06060	COG0488	(ABC) transporter
SII_RS06085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SII_RS06110	COG1028	Short-chain dehydrogenase reductase Sdr
SII_RS06140	COG0531	amino acid
SII_RS06145	COG0577	efflux transmembrane transporter activity
SII_RS06150	COG1136	(ABC) transporter
SII_RS06165	COG3279	Response regulator of the LytR AlgR family
SII_RS06180	COG0577	efflux transmembrane transporter activity
SII_RS06185	COG1136	(ABC) transporter
SII_RS06200	COG0745	RESPONSE REGULATOR receiver
SII_RS06210	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SII_RS06210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SII_RS06235	COG0640	Transcriptional regulator
SII_RS06250	COG0708	Exodeoxyribonuclease III
SII_RS06260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SII_RS06265	COG1393	Belongs to the ArsC family
SII_RS06270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SII_RS06280	COG4467	Involved in initiation control of chromosome replication
SII_RS06285	COG0470	DNA polymerase III
SII_RS06290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SII_RS06295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SII_RS06300	COG0517	IMP dehydrogenase activity
SII_RS06320	COG0559	Belongs to the binding-protein-dependent transport system permease family
SII_RS06335	COG0740	serine-type endopeptidase activity
SII_RS06340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SII_RS06345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SII_RS06350	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SII_RS06355	COG0626	cystathionine gamma-synthase activity
SII_RS06360	COG2244	polysaccharide biosynthetic process
SII_RS06365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SII_RS06390	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SII_RS06400	COG0366	Alpha amylase catalytic
SII_RS06405	COG1263	PTS System
SII_RS06405	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SII_RS06410	COG2188	Transcriptional regulator
SII_RS06415	COG1253	flavin adenine dinucleotide binding
SII_RS06425	COG0628	permease
SII_RS06430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SII_RS06435	COG3599	regulation of cell shape
SII_RS06450	COG1799	cell septum assembly
SII_RS06455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SII_RS06470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SII_RS06475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SII_RS06480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SII_RS06490	COG1217	gtp-binding protein TYPA
SII_RS06495	COG1187	pseudouridine synthase activity
SII_RS06515	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SII_RS06525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SII_RS06530	COG4470	Protein conserved in bacteria
SII_RS06535	COG3480	Lon protease (S16) C-terminal proteolytic domain
SII_RS06540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SII_RS06545	COG0742	ribosomal rna small subunit methyltransferase
SII_RS06555	COG1040	competence protein
SII_RS06560	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SII_RS06565	COG1739	Uncharacterized protein family UPF0029
SII_RS06600	COG0525	valine-tRNA ligase activity
SII_RS06610	COG0519	Catalyzes the synthesis of GMP from XMP
SII_RS06645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SII_RS06650	COG3231	kanamycin kinase activity
SII_RS06655	COG2137	regulation of response to DNA damage stimulus
SII_RS06660	COG3557	Belongs to the UPF0374 family
SII_RS06670	COG1185	polyribonucleotide nucleotidyltransferase activity
SII_RS06685	COG4585	Histidine kinase
SII_RS06695	COG2815	serine threonine protein kinase
SII_RS06695	COG0515	serine threonine protein kinase
SII_RS06700	COG0631	protein serine/threonine phosphatase activity
SII_RS06705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SII_RS06705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SII_RS06710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SII_RS06715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SII_RS06720	COG1758	RNA polymerase activity
SII_RS06725	COG0194	GDP metabolic process
SII_RS06730	COG1418	mRNA catabolic process
SII_RS06740	COG3634	alkyl hydroperoxide reductase activity
SII_RS06745	COG0450	alkyl hydroperoxide reductase
SII_RS06755	COG0116	Belongs to the methyltransferase superfamily
SII_RS06760	COG3599	regulation of cell shape
SII_RS06765	COG4474	Belongs to the UPF0398 family
SII_RS06770	COG3331	DNA recombination
SII_RS06775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SII_RS06780	COG3579	cysteine-type endopeptidase activity
SII_RS06785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SII_RS06790	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SII_RS06805	COG1113	amino acid transport
SII_RS06810	COG0492	ferredoxin-NADP+ reductase activity
SII_RS06820	COG1126	abc transporter atp-binding protein
SII_RS06830	COG0513	Belongs to the DEAD box helicase family
SII_RS06835	COG1686	Belongs to the peptidase S11 family
SII_RS06845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SII_RS06850	COG0719	Fe-S assembly protein
SII_RS06860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SII_RS06865	COG4862	establishment of competence for transformation
SII_RS06870	COG1968	undecaprenyl-diphosphatase activity
SII_RS06880	COG0765	amino acid transport
SII_RS06885	COG1126	abc transporter atp-binding protein
SII_RS06900	COG2197	response regulator
SII_RS06905	COG4585	Histidine kinase
SII_RS06915	COG1131	(ABC) transporter
SII_RS06920	COG1461	Dihydroxyacetone kinase
SII_RS06930	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SII_RS06950	COG0191	fructose-bisphosphate aldolase activity
SII_RS06965	COG0504	CTP synthase activity
SII_RS06975	COG4166	transmembrane transport
SII_RS06980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SII_RS06985	COG0768	penicillin binding
SII_RS07010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SII_RS07025	COG0751	glycine-tRNA ligase activity
SII_RS07030	COG0752	glycyl-tRNA synthetase alpha subunit
SII_RS07070	COG1283	sodium-dependent phosphate transmembrane transporter activity
SII_RS07075	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SII_RS07090	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SII_RS07095	COG0195	Participates in both transcription termination and antitermination
SII_RS07100	COG0779	Required for maturation of 30S ribosomal subunits
SII_RS07110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SII_RS07115	COG0510	thiamine kinase activity
SII_RS07125	COG1131	(ABC) transporter
SII_RS07130	COG0537	adenosine 5'-monophosphoramidase activity
SII_RS07140	COG1316	TRANSCRIPTIONal
SII_RS07150	COG0802	atpase or kinase
SII_RS07155	COG2252	PERMEase
SII_RS07165	COG0561	phosphatase activity
SII_RS07170	COG1064	alcohol dehydrogenase
SII_RS07180	COG3715	PTS system
SII_RS07185	COG3716	PTS system mannose fructose sorbose family IID component
SII_RS07200	COG0586	Pfam SNARE associated Golgi protein
SII_RS07205	COG0825	malonyl-CoA metabolic process
SII_RS07210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SII_RS07215	COG0439	Biotin carboxylase
SII_RS07220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SII_RS07230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SII_RS07235	COG1028	Short-chain dehydrogenase reductase Sdr
SII_RS07240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SII_RS07245	COG2070	2-Nitropropane dioxygenase
SII_RS07255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SII_RS07265	COG1024	Enoyl-CoA hydratase
SII_RS07270	COG0527	aspartate kinase activity
SII_RS07305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SII_RS07310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SII_RS07315	COG1464	Belongs to the NlpA lipoprotein family
SII_RS07320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SII_RS07335	COG1323	Belongs to the UPF0348 family
SII_RS07340	COG2226	methyltransferase
SII_RS07350	COG0799	negative regulation of ribosome biogenesis
SII_RS07355	COG1335	isochorismatase
SII_RS07360	COG1713	HD superfamily hydrolase involved in NAD metabolism
SII_RS07365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SII_RS07370	COG1534	Rna-binding protein
SII_RS07375	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SII_RS07380	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SII_RS07395	COG1063	alcohol dehydrogenase
SII_RS07400	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SII_RS07405	COG0154	amidase activity
SII_RS07410	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SII_RS07415	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SII_RS07420	COG1335	isochorismatase
SII_RS07425	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SII_RS07430	COG0436	Aminotransferase
SII_RS07435	COG0589	response to stress
SII_RS07440	COG0561	phosphatase activity
SII_RS07445	COG0252	asparaginase activity
SII_RS07450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SII_RS07455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SII_RS07460	COG0736	holo-[acyl-carrier-protein] synthase activity
SII_RS07465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SII_RS07475	COG0531	amino acid
SII_RS07505	COG1482	cell wall glycoprotein biosynthetic process
SII_RS07510	COG2188	Transcriptional regulator
SII_RS07515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SII_RS07520	COG2723	6-phospho-beta-galactosidase activity
SII_RS07530	COG1132	(ABC) transporter
SII_RS07545	COG1902	pentaerythritol trinitrate reductase activity
SII_RS07550	COG0242	peptide deformylase activity
SII_RS07555	COG1940	carbohydrate kinase activity
SII_RS07560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SII_RS07560	COG1263	PTS System
SII_RS07560	COG2190	(PTS) system
SII_RS07565	COG1621	beta-fructofuranosidase activity
SII_RS07570	COG1609	Transcriptional regulator
SII_RS07575	COG0561	phosphatase activity
SII_RS07580	COG4608	Belongs to the ABC transporter superfamily
SII_RS07585	COG0444	Belongs to the ABC transporter superfamily
SII_RS07590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SII_RS07595	COG0601	transmembrane transport
SII_RS07600	COG4166	transmembrane transport
SII_RS07605	COG4166	transmembrane transport
SII_RS07615	COG0504	CTP synthase activity
SII_RS07620	COG3343	RNA polymerase activity
SII_RS07625	COG0544	peptidyl-prolyl cis-trans isomerase activity
SII_RS07630	COG4475	Protein of unknown function (DUF436)
SII_RS07635	COG4720	Psort location CytoplasmicMembrane, score
SII_RS07640	COG0351	phosphomethylpyrimidine kinase
SII_RS07645	COG0101	tRNA pseudouridine synthase activity
SII_RS07655	COG0484	heat shock protein binding
SII_RS07660	COG0443	Heat shock 70 kDa protein
SII_RS07665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SII_RS07670	COG1420	regulation of RNA biosynthetic process
SII_RS07675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SII_RS07680	COG3037	sugar-specific permease SgaT UlaA
SII_RS07690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SII_RS07705	COG2848	UPF0210 protein
SII_RS07710	COG3830	Belongs to the UPF0237 family
SII_RS07715	COG1609	Transcriptional regulator
SII_RS07730	COG3716	PTS system mannose fructose sorbose family IID component
SII_RS07735	COG3715	PTS system
SII_RS07740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SII_RS07745	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SII_RS07755	COG1028	Short-chain dehydrogenase reductase Sdr
SII_RS07780	COG5492	domain, Protein
SII_RS07785	COG0386	Belongs to the glutathione peroxidase family
SII_RS07815	COG1131	(ABC) transporter
SII_RS07850	COG2217	Heavy metal translocating P-type atpase
SII_RS07860	COG3328	transposase activity
SII_RS07875	COG2184	nucleotidyltransferase activity
SII_RS07880	COG1132	(ABC) transporter
SII_RS07910	COG2946	Replication initiation factor
SII_RS07925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SII_RS07930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SII_RS07945	COG3842	ATPase activity
SII_RS07955	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SII_RS07960	COG0215	cysteine-tRNA ligase activity
SII_RS07970	COG1045	serine acetyltransferase
SII_RS07975	COG1185	polyribonucleotide nucleotidyltransferase activity
SII_RS07980	COG1164	Oligoendopeptidase f
SII_RS07995	COG1187	pseudouridine synthase activity
SII_RS08060	COG2309	aminopeptidase activity
SII_RS08070	COG2176	DNA-directed DNA polymerase activity
SII_RS08075	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SII_RS08080	COG1523	belongs to the glycosyl hydrolase 13 family
SII_RS08085	COG0495	leucyl-tRNA aminoacylation
SII_RS08090	COG3590	peptidase
SII_RS08125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SII_RS08150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SII_RS08170	COG0459	protein refolding
SII_RS08185	COG3716	PTS system mannose fructose sorbose family IID component
SII_RS08190	COG3715	PTS system
SII_RS08210	COG2197	response regulator
SII_RS08215	COG4585	Histidine kinase
SII_RS08230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SII_RS08235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SII_RS08245	COG1363	Peptidase, m42
SII_RS08260	COG0285	dihydrofolate synthase activity
SII_RS08270	COG0442	prolyl-tRNA aminoacylation
SII_RS08275	COG0750	zinc metalloprotease
SII_RS08280	COG4589	Belongs to the CDS family
SII_RS08285	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SII_RS08295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SII_RS08315	COG3623	hexulose-6-phosphate isomerase
SII_RS08325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SII_RS08335	COG3037	sugar-specific permease SgaT UlaA
SII_RS08395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SII_RS08420	COG4537	Required for transformation and DNA binding
SII_RS08425	COG1459	type II secretion system
SII_RS08430	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SII_RS08440	COG0174	glutamine synthetase
SII_RS08445	COG0789	Transcriptional regulator
SII_RS08455	COG3942	CHAP domain
SII_RS08465	COG0126	phosphoglycerate kinase activity
SII_RS08470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SII_RS08475	COG0085	RNA polymerase activity
SII_RS08480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SII_RS08480	COG4499	WXG100 protein secretion system (Wss), protein YukC
SII_RS08490	COG0500	methyltransferase
SII_RS08500	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SII_RS08505	COG1473	amidohydrolase
SII_RS08510	COG2171	N-acyltransferase activity
SII_RS08515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SII_RS08530	COG0756	dUTP diphosphatase activity
SII_RS08545	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SII_RS08550	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SII_RS08660	COG0203	ribosomal protein L17
SII_RS08665	COG0202	RNA polymerase activity
SII_RS08670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SII_RS08675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SII_RS08680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SII_RS08685	COG0563	adenylate kinase activity
SII_RS08690	COG0201	protein transport
SII_RS08695	COG0200	Binds to the 23S rRNA
SII_RS08700	COG1841	ribosomal large subunit assembly
SII_RS08705	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SII_RS08715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SII_RS08720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SII_RS08725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SII_RS08730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SII_RS08735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SII_RS08740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SII_RS08745	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SII_RS08750	COG0255	Belongs to the universal ribosomal protein uL29 family
SII_RS08755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SII_RS08760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SII_RS08765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SII_RS08775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SII_RS08780	COG0089	rRNA binding
SII_RS08785	COG0088	Forms part of the polypeptide exit tunnel
SII_RS08790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SII_RS08795	COG0051	transcription antitermination factor activity, RNA binding
SII_RS08805	COG0343	queuine tRNA-ribosyltransferase activity
SII_RS08820	COG1832	CoA-binding protein
SII_RS08825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SII_RS08825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SII_RS08850	COG5002	protein histidine kinase activity
SII_RS08880	COG1216	Glycosyl transferase, family 2
SII_RS08885	COG0438	transferase activity, transferring glycosyl groups
SII_RS08890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SII_RS08890	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SII_RS08895	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SII_RS08910	COG3944	biosynthesis protein
SII_RS08915	COG4464	protein tyrosine phosphatase activity
SII_RS08925	COG0602	queuosine metabolic process
SII_RS08950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SII_RS08970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SII_RS08975	COG4472	Bacterial protein of unknown function (DUF965)
SII_RS08990	COG1393	Belongs to the ArsC family
SII_RS08995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SII_RS09000	COG1546	Belongs to the CinA family
SII_RS09000	COG1058	Belongs to the CinA family
SII_RS09010	COG2818	Glycosylase
SII_RS09015	COG0632	four-way junction helicase activity
SII_RS09020	COG1395	domain, Protein
SII_RS09030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SII_RS09045	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SII_RS09050	COG1438	arginine binding
SII_RS09055	COG0018	arginyl-trna synthetase
SII_RS09060	COG1780	Probably involved in ribonucleotide reductase function
SII_RS09070	COG0058	SHG alpha-glucan phosphorylase activity
SII_RS09075	COG1640	4-alpha-glucanotransferase
SII_RS09085	COG2182	Extracellular solute-binding protein
SII_RS09090	COG1175	transmembrane transport
SII_RS09095	COG3833	ABC-type maltose transport systems, permease component
SII_RS09100	COG5521	maltodextrose utilization protein MalA
SII_RS09105	COG1609	Transcriptional regulator
SII_RS09110	COG1523	belongs to the glycosyl hydrolase 13 family
SII_RS09115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SII_RS09130	COG0124	histidyl-tRNA synthetase
SII_RS09135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SII_RS09140	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SII_RS09220	COG1396	sequence-specific DNA binding
SII_RS09225	COG2217	Heavy metal translocating P-type atpase
SII_RS09230	COG1230	cation diffusion facilitator family transporter
SII_RS09240	COG2807	transmembrane transport
SII_RS09250	COG2094	Belongs to the DNA glycosylase MPG family
SII_RS09260	COG0561	phosphatase activity
SII_RS09270	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SII_RS09275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SII_RS09280	COG1696	Membrane protein involved in D-alanine export
SII_RS09350	COG0561	phosphatase activity
SII_RS09365	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SII_RS09370	COG1011	Hydrolase
SII_RS09380	COG0305	Participates in initiation and elongation during chromosome replication
SII_RS09395	COG0445	tRNA wobble uridine modification
SII_RS09400	COG0482	sulfurtransferase activity
SII_RS09410	COG1760	l-serine dehydratase
SII_RS09415	COG1760	l-serine dehydratase
SII_RS09425	COG0741	lytic transglycosylase activity
SII_RS09430	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SII_RS09435	COG1122	ATPase activity
SII_RS09440	COG1122	ATPase activity
SII_RS09445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SII_RS09455	COG0612	Peptidase, M16
SII_RS09460	COG0612	Peptidase, M16
SII_RS09470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SII_RS09475	COG0517	IMP dehydrogenase activity
SII_RS09475	COG0516	GMP reductase activity
SII_RS09480	COG0180	Tryptophanyl-tRNA synthetase
SII_RS09485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SII_RS09490	COG0149	triose-phosphate isomerase activity
SII_RS09500	COG0488	(ABC) transporter
SII_RS09525	COG4191	Histidine kinase
SII_RS09540	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SII_RS09545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SII_RS09550	COG1475	DNA binding