locus-tag	class	description
A6J72_RS00005	COG3842	ATPase activity
A6J72_RS00010	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6J72_RS00015	COG1177	transmembrane transport
A6J72_RS00030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J72_RS00035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J72_RS00050	COG3708	Transcriptional regulator
A6J72_RS00050	COG2207	Transcriptional regulator
A6J72_RS00055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6J72_RS00060	COG0222	ribosome binding
A6J72_RS00115	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6J72_RS00120	COG0336	Belongs to the RNA methyltransferase TrmD family
A6J72_RS00125	COG3443	Belongs to the bacterial solute-binding protein 9 family
A6J72_RS00125	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J72_RS00145	COG1956	GAF domain-containing protein
A6J72_RS00150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J72_RS00155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6J72_RS00165	COG0251	oxidation-reduction process
A6J72_RS00170	COG0626	cystathionine gamma-synthase activity
A6J72_RS00175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J72_RS00185	COG2860	membrane
A6J72_RS00195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6J72_RS00195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6J72_RS00200	COG1609	Transcriptional regulator
A6J72_RS00205	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6J72_RS00220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6J72_RS00230	COG0726	polysaccharide deacetylase
A6J72_RS00240	COG0083	homoserine kinase activity
A6J72_RS00260	COG2814	Major facilitator Superfamily
A6J72_RS00270	COG0543	2 iron, 2 sulfur cluster binding
A6J72_RS00275	COG0167	dihydroorotate dehydrogenase activity
A6J72_RS00280	COG0284	orotidine-5'-phosphate decarboxylase activity
A6J72_RS00290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6J72_RS00295	COG4479	Belongs to the UPF0346 family
A6J72_RS00300	COG1702	phosphate starvation-inducible protein PhoH
A6J72_RS00320	COG0686	Belongs to the AlaDH PNT family
A6J72_RS00335	COG1132	(ABC) transporter
A6J72_RS00340	COG1132	(ABC) transporter
A6J72_RS00350	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J72_RS00375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6J72_RS00380	COG0237	dephospho-CoA kinase activity
A6J72_RS00385	COG2814	Major facilitator Superfamily
A6J72_RS00390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J72_RS00400	COG0557	exoribonuclease II activity
A6J72_RS00405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J72_RS00415	COG2333	competence protein COMEC
A6J72_RS00415	COG0658	competence protein
A6J72_RS00430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J72_RS00435	COG1051	belongs to the nudix hydrolase family
A6J72_RS00440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6J72_RS00445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6J72_RS00450	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J72_RS00455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J72_RS00460	COG4109	DRTGG domain
A6J72_RS00475	COG1846	Transcriptional regulator
A6J72_RS00485	COG2246	polysaccharide biosynthetic process
A6J72_RS00490	COG4708	membrane
A6J72_RS00500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6J72_RS00505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J72_RS00510	COG1597	lipid kinase activity
A6J72_RS00515	COG1523	belongs to the glycosyl hydrolase 13 family
A6J72_RS00520	COG0228	four-way junction DNA binding
A6J72_RS00525	COG1837	Belongs to the UPF0109 family
A6J72_RS00530	COG1827	regulation of RNA biosynthetic process
A6J72_RS00545	COG3142	Participates in the control of copper homeostasis
A6J72_RS00550	COG2315	Protein conserved in bacteria
A6J72_RS00555	COG1132	(ABC) transporter
A6J72_RS00560	COG1132	(ABC) transporter
A6J72_RS00565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6J72_RS00580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6J72_RS00590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J72_RS00665	COG0758	DNA mediated transformation
A6J72_RS00670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J72_RS00680	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6J72_RS00700	COG4974	Belongs to the 'phage' integrase family
A6J72_RS00705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J72_RS00715	COG2188	Transcriptional regulator
A6J72_RS00730	COG0741	lytic transglycosylase activity
A6J72_RS00740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6J72_RS00745	COG0009	L-threonylcarbamoyladenylate synthase
A6J72_RS00750	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J72_RS00755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J72_RS00760	COG1435	thymidine kinase activity
A6J72_RS00765	COG1942	4-Oxalocrotonate Tautomerase
A6J72_RS00770	COG0534	Mate efflux family protein
A6J72_RS00775	COG2233	PERMEase
A6J72_RS00780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J72_RS00820	COG0431	NADPH-dependent FMN reductase
A6J72_RS00820	COG1053	succinate dehydrogenase
A6J72_RS00820	COG3976	FMN-binding domain protein
A6J72_RS00825	COG4555	ABC transporter
A6J72_RS00840	COG2972	Histidine kinase
A6J72_RS00845	COG4753	response regulator
A6J72_RS00845	COG2207	Transcriptional regulator
A6J72_RS00850	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J72_RS00850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J72_RS00855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J72_RS00860	COG0785	Cytochrome C biogenesis protein
A6J72_RS00870	COG2151	metal-sulfur cluster biosynthetic enzyme
A6J72_RS00875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J72_RS00880	COG0358	DNA primase activity
A6J72_RS00885	COG1970	mechanosensitive ion channel activity
A6J72_RS00890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J72_RS00895	COG3764	Sortase (surface protein transpeptidase)
A6J72_RS00900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J72_RS00905	COG0039	L-malate dehydrogenase activity
A6J72_RS00910	COG0494	nUDIX hydrolase
A6J72_RS00920	COG0539	negative regulation of cytoplasmic translation
A6J72_RS00940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6J72_RS00945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J72_RS00955	COG0187	DNA topoisomerase II activity
A6J72_RS00960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6J72_RS00970	COG2131	deaminase
A6J72_RS00975	COG1309	transcriptional regulator
A6J72_RS01040	COG2814	Major facilitator Superfamily
A6J72_RS01045	COG0017	Asparaginyl-tRNA synthetase
A6J72_RS01055	COG0436	Aminotransferase
A6J72_RS01065	COG1846	Transcriptional regulator
A6J72_RS01075	COG3022	response to hydroperoxide
A6J72_RS01085	COG1272	protein, Hemolysin III
A6J72_RS01090	COG1079	Belongs to the binding-protein-dependent transport system permease family
A6J72_RS01095	COG4603	Belongs to the binding-protein-dependent transport system permease family
A6J72_RS01100	COG3845	ABC transporter
A6J72_RS01105	COG1744	ABC transporter substrate-binding protein PnrA-like
A6J72_RS01110	COG0295	cytidine deaminase activity
A6J72_RS01115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6J72_RS01125	COG2813	Specifically methylates the guanine in position
A6J72_RS01130	COG1072	(Pantothenic acid kinase))
A6J72_RS01150	COG5002	protein histidine kinase activity
A6J72_RS01155	COG0745	RESPONSE REGULATOR receiver
A6J72_RS01180	COG1940	carbohydrate kinase activity
A6J72_RS01185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6J72_RS01190	COG0505	Belongs to the CarA family
A6J72_RS01195	COG0540	Belongs to the ATCase OTCase family
A6J72_RS01205	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6J72_RS01215	COG1481	regulation of sporulation
A6J72_RS01220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A6J72_RS01225	COG1660	Displays ATPase and GTPase activities
A6J72_RS01245	COG0647	UMP catabolic process
A6J72_RS01250	COG1051	belongs to the nudix hydrolase family
A6J72_RS01260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J72_RS01270	COG0456	acetyltransferase
A6J72_RS01275	COG0556	nucleotide-excision repair
A6J72_RS01290	COG0488	(ABC) transporter
A6J72_RS01295	COG1132	(ABC) transporter
A6J72_RS01310	COG1388	LysM domain
A6J72_RS01310	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6J72_RS01315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6J72_RS01320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6J72_RS01330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6J72_RS01335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6J72_RS01340	COG0038	chloride channel
A6J72_RS01360	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J72_RS01370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6J72_RS01375	COG0564	pseudouridine synthase activity
A6J72_RS01380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6J72_RS01385	COG0583	DNA-binding transcription factor activity
A6J72_RS01400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J72_RS01405	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6J72_RS01415	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6J72_RS01425	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6J72_RS01435	COG0301	tRNA thio-modification
A6J72_RS01440	COG1104	cysteine desulfurase activity
A6J72_RS01445	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A6J72_RS01450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6J72_RS01455	COG0517	IMP dehydrogenase activity
A6J72_RS01460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J72_RS01460	COG0574	Belongs to the PEP-utilizing enzyme family
A6J72_RS01470	COG0552	protein localization to endoplasmic reticulum
A6J72_RS01475	COG0561	phosphatase activity
A6J72_RS01480	COG0561	phosphatase activity
A6J72_RS01485	COG1196	nuclear chromosome segregation
A6J72_RS01490	COG0571	ribonuclease III activity
A6J72_RS01495	COG2832	Protein of unknown function (DUF454)
A6J72_RS01500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6J72_RS01505	COG5002	protein histidine kinase activity
A6J72_RS01510	COG0745	RESPONSE REGULATOR receiver
A6J72_RS01520	COG0438	transferase activity, transferring glycosyl groups
A6J72_RS01530	COG1609	Transcriptional regulator
A6J72_RS01535	COG0006	proline dipeptidase activity
A6J72_RS01540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J72_RS01545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J72_RS01550	COG1088	dTDP-glucose 4,6-dehydratase activity
A6J72_RS01560	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6J72_RS01565	COG1051	belongs to the nudix hydrolase family
A6J72_RS01570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6J72_RS01575	COG2384	SAM-dependent methyltransferase
A6J72_RS01580	COG1368	sulfuric ester hydrolase activity
A6J72_RS01615	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6J72_RS01620	COG0463	Glycosyl transferase, family 2
A6J72_RS01635	COG1216	Glycosyl transferase, family 2
A6J72_RS01635	COG1442	glycosyl transferase family 8
A6J72_RS01660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J72_RS01670	COG0077	Prephenate dehydratase
A6J72_RS01680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6J72_RS01690	COG3679	Belongs to the UPF0342 family
A6J72_RS01695	COG0287	Prephenate dehydrogenase
A6J72_RS01705	COG0730	response to heat
A6J72_RS01710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6J72_RS01715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6J72_RS01720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J72_RS01725	COG0710	3-dehydroquinate dehydratase activity
A6J72_RS01730	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6J72_RS01735	COG1368	sulfuric ester hydrolase activity
A6J72_RS01755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6J72_RS01760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J72_RS01790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J72_RS01800	COG1191	sigma factor activity
A6J72_RS01805	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A6J72_RS01810	COG0772	Belongs to the SEDS family
A6J72_RS01825	COG1125	glycine betaine transport
A6J72_RS01830	COG1174	glycine betaine transport
A6J72_RS01840	COG1573	uracil-dna glycosylase
A6J72_RS01860	COG1132	(ABC) transporter
A6J72_RS01900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J72_RS01910	COG0322	excinuclease ABC activity
A6J72_RS01915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6J72_RS01925	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6J72_RS01965	COG0204	Acyl-transferase
A6J72_RS01970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J72_RS01985	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6J72_RS01990	COG0406	alpha-ribazole phosphatase activity
A6J72_RS01995	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6J72_RS02030	COG2207	Transcriptional regulator
A6J72_RS02030	COG4753	response regulator
A6J72_RS02035	COG2972	Histidine kinase
A6J72_RS02045	COG1653	transport
A6J72_RS02050	COG0395	ABC-type sugar transport system, permease component
A6J72_RS02055	COG4209	transmembrane transport
A6J72_RS02070	COG0383	alpha-mannosidase activity
A6J72_RS02080	COG3537	Alpha-1,2-mannosidase
A6J72_RS02130	COG1882	Formate acetyltransferase
A6J72_RS02135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J72_RS02145	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J72_RS02155	COG1349	DNA-binding transcription factor activity
A6J72_RS02160	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J72_RS02165	COG1959	2 iron, 2 sulfur cluster binding
A6J72_RS02185	COG1309	transcriptional regulator
A6J72_RS02200	COG3850	Histidine kinase
A6J72_RS02200	COG5002	protein histidine kinase activity
A6J72_RS02205	COG0745	RESPONSE REGULATOR receiver
A6J72_RS02210	COG2706	6-phosphogluconolactonase activity
A6J72_RS02215	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A6J72_RS02220	COG0187	DNA topoisomerase II activity
A6J72_RS02230	COG0693	protein deglycase activity
A6J72_RS02235	COG0772	Belongs to the SEDS family
A6J72_RS02245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6J72_RS02245	COG1199	ATP-dependent helicase activity
A6J72_RS02255	COG2177	Part of the ABC transporter FtsEX involved in
A6J72_RS02260	COG2884	Cell division ATP-binding protein ftsE
A6J72_RS02280	COG1078	dGTPase activity
A6J72_RS02290	COG2348	transferase activity, transferring amino-acyl groups
A6J72_RS02300	COG3842	ATPase activity
A6J72_RS02305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J72_RS02315	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J72_RS02320	COG4122	O-methyltransferase activity
A6J72_RS02355	COG0363	glucosamine-6-phosphate deaminase activity
A6J72_RS02360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6J72_RS02365	COG1438	arginine binding
A6J72_RS02370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J72_RS02375	COG1288	antiporter activity
A6J72_RS02380	COG0549	Belongs to the carbamate kinase family
A6J72_RS02385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6J72_RS02465	COG3290	protein histidine kinase activity
A6J72_RS02475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J72_RS02480	COG2274	protein secretion by the type I secretion system
A6J72_RS02495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J72_RS02505	COG2996	Protein conserved in bacteria
A6J72_RS02510	COG0233	cytoplasmic translational termination
A6J72_RS02515	COG0528	UMP kinase activity
A6J72_RS02520	COG0081	regulation of translation
A6J72_RS02525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6J72_RS02535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J72_RS02540	COG0697	spore germination
A6J72_RS02540	COG1674	ftsk spoiiie
A6J72_RS02545	COG1983	PspC domain protein
A6J72_RS02560	COG0488	(ABC) transporter
A6J72_RS02570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J72_RS02585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J72_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
A6J72_RS02640	COG0531	amino acid
A6J72_RS02645	COG0577	efflux transmembrane transporter activity
A6J72_RS02650	COG1136	(ABC) transporter
A6J72_RS02665	COG3279	Response regulator of the LytR AlgR family
A6J72_RS02680	COG0577	efflux transmembrane transporter activity
A6J72_RS02685	COG1136	(ABC) transporter
A6J72_RS02700	COG0745	RESPONSE REGULATOR receiver
A6J72_RS02710	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J72_RS02710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J72_RS02735	COG0640	Transcriptional regulator
A6J72_RS02745	COG0708	Exodeoxyribonuclease III
A6J72_RS02755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J72_RS02760	COG1393	Belongs to the ArsC family
A6J72_RS02765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J72_RS02775	COG4467	Involved in initiation control of chromosome replication
A6J72_RS02780	COG0470	DNA polymerase III
A6J72_RS02785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6J72_RS02790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J72_RS02795	COG0517	IMP dehydrogenase activity
A6J72_RS02815	COG0559	Belongs to the binding-protein-dependent transport system permease family
A6J72_RS02825	COG4471	UPF0298 protein
A6J72_RS02830	COG0740	serine-type endopeptidase activity
A6J72_RS02835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6J72_RS02840	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6J72_RS02845	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6J72_RS02850	COG0626	cystathionine gamma-synthase activity
A6J72_RS02855	COG2244	polysaccharide biosynthetic process
A6J72_RS02860	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J72_RS02890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6J72_RS02900	COG0366	Alpha amylase catalytic
A6J72_RS02905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J72_RS02905	COG1263	PTS System
A6J72_RS02910	COG2188	Transcriptional regulator
A6J72_RS02915	COG1253	flavin adenine dinucleotide binding
A6J72_RS02925	COG0628	permease
A6J72_RS02930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J72_RS02935	COG3599	regulation of cell shape
A6J72_RS02950	COG1799	cell septum assembly
A6J72_RS02955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J72_RS02970	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6J72_RS02975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6J72_RS02980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6J72_RS02990	COG1217	gtp-binding protein TYPA
A6J72_RS02995	COG1187	pseudouridine synthase activity
A6J72_RS03015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A6J72_RS03025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J72_RS03030	COG4470	Protein conserved in bacteria
A6J72_RS03035	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6J72_RS03040	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6J72_RS03045	COG0742	ribosomal rna small subunit methyltransferase
A6J72_RS03055	COG1040	competence protein
A6J72_RS03065	COG1739	Uncharacterized protein family UPF0029
A6J72_RS03105	COG0525	valine-tRNA ligase activity
A6J72_RS03115	COG0519	Catalyzes the synthesis of GMP from XMP
A6J72_RS03145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J72_RS03150	COG3231	kanamycin kinase activity
A6J72_RS03155	COG2137	regulation of response to DNA damage stimulus
A6J72_RS03160	COG3557	Belongs to the UPF0374 family
A6J72_RS03170	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J72_RS03185	COG4585	Histidine kinase
A6J72_RS03195	COG0515	serine threonine protein kinase
A6J72_RS03195	COG2815	serine threonine protein kinase
A6J72_RS03200	COG0631	protein serine/threonine phosphatase activity
A6J72_RS03205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J72_RS03205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6J72_RS03210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J72_RS03215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J72_RS03220	COG1758	RNA polymerase activity
A6J72_RS03225	COG0194	GDP metabolic process
A6J72_RS03230	COG1418	mRNA catabolic process
A6J72_RS03240	COG3634	alkyl hydroperoxide reductase activity
A6J72_RS03245	COG0450	alkyl hydroperoxide reductase
A6J72_RS03255	COG0116	Belongs to the methyltransferase superfamily
A6J72_RS03265	COG3599	regulation of cell shape
A6J72_RS03270	COG4474	Belongs to the UPF0398 family
A6J72_RS03275	COG3331	DNA recombination
A6J72_RS03280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J72_RS03285	COG3579	cysteine-type endopeptidase activity
A6J72_RS03290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J72_RS03295	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6J72_RS03310	COG1113	amino acid transport
A6J72_RS03315	COG0492	ferredoxin-NADP+ reductase activity
A6J72_RS03325	COG1126	abc transporter atp-binding protein
A6J72_RS03335	COG0513	Belongs to the DEAD box helicase family
A6J72_RS03340	COG1686	Belongs to the peptidase S11 family
A6J72_RS03350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J72_RS03355	COG0719	Fe-S assembly protein
A6J72_RS03365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J72_RS03370	COG4862	establishment of competence for transformation
A6J72_RS03375	COG1968	undecaprenyl-diphosphatase activity
A6J72_RS03385	COG0765	amino acid transport
A6J72_RS03390	COG1126	abc transporter atp-binding protein
A6J72_RS03405	COG2197	response regulator
A6J72_RS03410	COG4585	Histidine kinase
A6J72_RS03415	COG0842	Transport permease protein
A6J72_RS03420	COG1131	(ABC) transporter
A6J72_RS03425	COG1461	Dihydroxyacetone kinase
A6J72_RS03435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6J72_RS03455	COG0191	fructose-bisphosphate aldolase activity
A6J72_RS03470	COG0504	CTP synthase activity
A6J72_RS03485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J72_RS03490	COG0768	penicillin binding
A6J72_RS03510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J72_RS03525	COG0751	glycine-tRNA ligase activity
A6J72_RS03530	COG0752	glycyl-tRNA synthetase alpha subunit
A6J72_RS03535	COG1673	EVE domain
A6J72_RS03540	COG1846	Transcriptional regulator
A6J72_RS03570	COG0732	type I restriction modification DNA specificity domain
A6J72_RS03575	COG5290	Psort location Cytoplasmic, score
A6J72_RS03585	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6J72_RS03595	COG1283	sodium-dependent phosphate transmembrane transporter activity
A6J72_RS03600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6J72_RS03615	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6J72_RS03620	COG0195	Participates in both transcription termination and antitermination
A6J72_RS03625	COG0779	Required for maturation of 30S ribosomal subunits
A6J72_RS03635	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J72_RS03640	COG0510	thiamine kinase activity
A6J72_RS03650	COG1131	(ABC) transporter
A6J72_RS03655	COG0537	adenosine 5'-monophosphoramidase activity
A6J72_RS03665	COG1316	TRANSCRIPTIONal
A6J72_RS03675	COG0802	atpase or kinase
A6J72_RS03680	COG2252	PERMEase
A6J72_RS03690	COG0561	phosphatase activity
A6J72_RS03695	COG1064	alcohol dehydrogenase
A6J72_RS03705	COG3715	PTS system
A6J72_RS03710	COG3716	PTS system mannose fructose sorbose family IID component
A6J72_RS03725	COG0586	Pfam SNARE associated Golgi protein
A6J72_RS03730	COG0825	malonyl-CoA metabolic process
A6J72_RS03735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J72_RS03740	COG0439	Biotin carboxylase
A6J72_RS03745	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J72_RS03755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J72_RS03760	COG1028	Short-chain dehydrogenase reductase Sdr
A6J72_RS03765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J72_RS03770	COG2070	2-Nitropropane dioxygenase
A6J72_RS03780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J72_RS03790	COG1024	Enoyl-CoA hydratase
A6J72_RS03795	COG0527	aspartate kinase activity
A6J72_RS03840	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J72_RS03845	COG0006	proline dipeptidase activity
A6J72_RS03855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J72_RS03875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6J72_RS03880	COG0629	single-stranded DNA binding
A6J72_RS03915	COG2134	cdp-diacylglycerol pyrophosphatase
A6J72_RS03925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6J72_RS03935	COG1122	ATPase activity
A6J72_RS03945	COG0366	Alpha amylase catalytic
A6J72_RS03960	COG5002	protein histidine kinase activity
A6J72_RS03965	COG0745	RESPONSE REGULATOR receiver
A6J72_RS03985	COG1401	restriction endodeoxyribonuclease activity
A6J72_RS04010	COG2207	Transcriptional regulator
A6J72_RS04025	COG1309	transcriptional regulator
A6J72_RS04030	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J72_RS04035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J72_RS04050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J72_RS04055	COG1940	carbohydrate kinase activity
A6J72_RS04060	COG1136	(ABC) transporter
A6J72_RS04075	COG0402	S-adenosylhomocysteine deaminase activity
A6J72_RS04080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J72_RS04080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J72_RS04085	COG0167	dihydroorotate dehydrogenase activity
A6J72_RS04090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6J72_RS04100	COG5504	Zn-dependent protease
A6J72_RS04110	COG0668	transmembrane transport
A6J72_RS04115	COG0531	amino acid
A6J72_RS04125	COG0583	DNA-binding transcription factor activity
A6J72_RS04135	COG3118	belongs to the thioredoxin family
A6J72_RS04145	COG1193	negative regulation of DNA recombination
A6J72_RS04165	COG0681	Belongs to the peptidase S26 family
A6J72_RS04170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J72_RS04175	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6J72_RS04180	COG1882	Formate acetyltransferase
A6J72_RS04195	COG3425	synthase
A6J72_RS04205	COG1304	FMN binding
A6J72_RS04240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J72_RS04250	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6J72_RS04260	COG1131	(ABC) transporter
A6J72_RS04280	COG0584	glycerophosphoryl diester phosphodiesterase
A6J72_RS04295	COG2081	HI0933 family
A6J72_RS04305	COG0789	Transcriptional regulator
A6J72_RS04335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6J72_RS04345	COG1214	PFAM Peptidase M22, glycoprotease
A6J72_RS04365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6J72_RS04370	COG0049	tRNA binding
A6J72_RS04375	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6J72_RS04385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J72_RS04390	COG3481	metal-dependent phosphohydrolase, HD sub domain
A6J72_RS04400	COG1564	THIamine pyrophosphokinase
A6J72_RS04410	COG1162	GTPase activity
A6J72_RS04425	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J72_RS04445	COG0084	hydrolase, TatD family'
A6J72_RS04450	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6J72_RS04475	COG0594	ribonuclease P activity
A6J72_RS04485	COG0166	Belongs to the GPI family
A6J72_RS04520	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J72_RS04550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6J72_RS04555	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J72_RS04570	COG4463	regulation of RNA biosynthetic process
A6J72_RS04580	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J72_RS04585	COG0052	Belongs to the universal ribosomal protein uS2 family
A6J72_RS04610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J72_RS04615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J72_RS04620	COG0564	pseudouridine synthase activity
A6J72_RS04640	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6J72_RS04640	COG3443	Belongs to the bacterial solute-binding protein 9 family
A6J72_RS04645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J72_RS04650	COG1121	(ABC) transporter
A6J72_RS04655	COG1846	Transcriptional regulator
A6J72_RS04670	COG4932	domain protein
A6J72_RS04695	COG1394	ATPase activity, coupled to movement of substances
A6J72_RS04700	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A6J72_RS04705	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A6J72_RS04715	COG1527	subunit (C
A6J72_RS04725	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J72_RS04730	COG1269	ATP hydrolysis coupled proton transport
A6J72_RS04745	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6J72_RS04750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J72_RS04750	COG1263	PTS System
A6J72_RS04770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J72_RS04785	COG0395	ABC-type sugar transport system, permease component
A6J72_RS04790	COG1175	transmembrane transport
A6J72_RS04800	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A6J72_RS04925	COG4499	WXG100 protein secretion system (Wss), protein YukC
A6J72_RS04940	COG4842	Belongs to the WXG100 family
A6J72_RS04945	COG1454	alcohol dehydrogenase
A6J72_RS04945	COG1012	belongs to the aldehyde dehydrogenase family
A6J72_RS04960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J72_RS05015	COG2255	four-way junction helicase activity
A6J72_RS05035	COG2222	sugar isomerase
A6J72_RS05045	COG3716	PTS system mannose fructose sorbose family IID component
A6J72_RS05055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J72_RS05070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6J72_RS05075	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A6J72_RS05080	COG1461	Dihydroxyacetone kinase
A6J72_RS05085	COG2376	Dihydroxyacetone kinase
A6J72_RS05095	COG2376	Dihydroxyacetone kinase
A6J72_RS05100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J72_RS05125	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J72_RS05135	COG3942	CHAP domain
A6J72_RS05140	COG0138	bifunctional purine biosynthesis protein purh
A6J72_RS05155	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J72_RS05160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6J72_RS05165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J72_RS05175	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J72_RS05180	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6J72_RS05185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J72_RS05195	COG1381	Involved in DNA repair and RecF pathway recombination
A6J72_RS05200	COG0436	Aminotransferase
A6J72_RS05205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J72_RS05210	COG3942	CHAP domain
A6J72_RS05220	COG1792	Involved in formation and maintenance of cell shape
A6J72_RS05340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J72_RS05345	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6J72_RS05350	COG0037	tRNA processing
A6J72_RS05365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J72_RS05370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J72_RS05375	COG0193	aminoacyl-tRNA hydrolase activity
A6J72_RS05380	COG0012	GTP binding
A6J72_RS05395	COG0592	DNA-directed DNA polymerase activity
A6J72_RS05405	COG1475	DNA binding
A6J72_RS05410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J72_RS05415	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6J72_RS05430	COG4191	Histidine kinase
A6J72_RS05455	COG0488	(ABC) transporter
A6J72_RS05465	COG0149	triose-phosphate isomerase activity
A6J72_RS05470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J72_RS05475	COG0180	Tryptophanyl-tRNA synthetase
A6J72_RS05480	COG0517	IMP dehydrogenase activity
A6J72_RS05480	COG0516	GMP reductase activity
A6J72_RS05485	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6J72_RS05495	COG0612	Peptidase, M16
A6J72_RS05500	COG0612	Peptidase, M16
A6J72_RS05510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6J72_RS05515	COG1122	ATPase activity
A6J72_RS05520	COG1122	ATPase activity
A6J72_RS05525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A6J72_RS05530	COG0741	lytic transglycosylase activity
A6J72_RS05540	COG1760	l-serine dehydratase
A6J72_RS05545	COG1760	l-serine dehydratase
A6J72_RS05555	COG0482	sulfurtransferase activity
A6J72_RS05560	COG0445	tRNA wobble uridine modification
A6J72_RS05575	COG0305	Participates in initiation and elongation during chromosome replication
A6J72_RS05585	COG1011	Hydrolase
A6J72_RS05590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6J72_RS05605	COG0561	phosphatase activity
A6J72_RS05675	COG1696	Membrane protein involved in D-alanine export
A6J72_RS05680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J72_RS05685	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6J72_RS05695	COG0561	phosphatase activity
A6J72_RS05705	COG2094	Belongs to the DNA glycosylase MPG family
A6J72_RS05710	COG2807	transmembrane transport
A6J72_RS05730	COG2217	Heavy metal translocating P-type atpase
A6J72_RS05735	COG1396	sequence-specific DNA binding
A6J72_RS05805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J72_RS05810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6J72_RS05815	COG0124	histidyl-tRNA synthetase
A6J72_RS05830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6J72_RS05835	COG1523	belongs to the glycosyl hydrolase 13 family
A6J72_RS05840	COG1609	Transcriptional regulator
A6J72_RS05845	COG5521	maltodextrose utilization protein MalA
A6J72_RS05850	COG3833	ABC-type maltose transport systems, permease component
A6J72_RS05855	COG1175	transmembrane transport
A6J72_RS05860	COG2182	Extracellular solute-binding protein
A6J72_RS05870	COG1640	4-alpha-glucanotransferase
A6J72_RS05875	COG0058	SHG alpha-glucan phosphorylase activity
A6J72_RS05885	COG1780	Probably involved in ribonucleotide reductase function
A6J72_RS05890	COG0018	arginyl-trna synthetase
A6J72_RS05895	COG1438	arginine binding
A6J72_RS05900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6J72_RS05915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6J72_RS05925	COG1395	domain, Protein
A6J72_RS05930	COG0632	four-way junction helicase activity
A6J72_RS05935	COG2818	Glycosylase
A6J72_RS05945	COG1546	Belongs to the CinA family
A6J72_RS05945	COG1058	Belongs to the CinA family
A6J72_RS05950	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6J72_RS05955	COG1393	Belongs to the ArsC family
A6J72_RS05965	COG4472	Bacterial protein of unknown function (DUF965)
A6J72_RS05970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6J72_RS05990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6J72_RS06015	COG0602	queuosine metabolic process
A6J72_RS06025	COG4464	protein tyrosine phosphatase activity
A6J72_RS06030	COG3944	biosynthesis protein
A6J72_RS06045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J72_RS06050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J72_RS06060	COG0438	transferase activity, transferring glycosyl groups
A6J72_RS06080	COG0438	transferase activity, transferring glycosyl groups
A6J72_RS06085	COG1215	transferase activity, transferring glycosyl groups
A6J72_RS06100	COG4750	Nucleotidyl transferase
A6J72_RS06130	COG5002	protein histidine kinase activity
A6J72_RS06160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J72_RS06160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6J72_RS06165	COG1832	CoA-binding protein
A6J72_RS06180	COG0343	queuine tRNA-ribosyltransferase activity
A6J72_RS06190	COG0051	transcription antitermination factor activity, RNA binding
A6J72_RS06195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6J72_RS06200	COG0088	Forms part of the polypeptide exit tunnel
A6J72_RS06205	COG0089	rRNA binding
A6J72_RS06210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6J72_RS06220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6J72_RS06225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6J72_RS06230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6J72_RS06235	COG0255	Belongs to the universal ribosomal protein uL29 family
A6J72_RS06240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6J72_RS06245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6J72_RS06250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6J72_RS06255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6J72_RS06260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6J72_RS06265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6J72_RS06270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6J72_RS06280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6J72_RS06285	COG1841	ribosomal large subunit assembly
A6J72_RS06290	COG0200	Binds to the 23S rRNA
A6J72_RS06295	COG0201	protein transport
A6J72_RS06300	COG0563	adenylate kinase activity
A6J72_RS06305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6J72_RS06310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J72_RS06315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6J72_RS06320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6J72_RS06325	COG0202	RNA polymerase activity
A6J72_RS06330	COG0203	ribosomal protein L17
A6J72_RS06445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6J72_RS06450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6J72_RS06460	COG0756	dUTP diphosphatase activity
A6J72_RS06475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J72_RS06480	COG2171	N-acyltransferase activity
A6J72_RS06485	COG1473	amidohydrolase
A6J72_RS06490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6J72_RS06500	COG0500	methyltransferase
A6J72_RS06510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6J72_RS06510	COG4499	WXG100 protein secretion system (Wss), protein YukC
A6J72_RS06515	COG0085	RNA polymerase activity
A6J72_RS06520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6J72_RS06525	COG0126	phosphoglycerate kinase activity
A6J72_RS06535	COG3942	CHAP domain
A6J72_RS06545	COG0789	Transcriptional regulator
A6J72_RS06550	COG0174	glutamine synthetase
A6J72_RS06560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J72_RS06565	COG1459	type II secretion system
A6J72_RS06570	COG4537	Required for transformation and DNA binding
A6J72_RS06600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6J72_RS06660	COG3037	sugar-specific permease SgaT UlaA
A6J72_RS06670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J72_RS06680	COG3623	hexulose-6-phosphate isomerase
A6J72_RS06700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6J72_RS06715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6J72_RS06720	COG4589	Belongs to the CDS family
A6J72_RS06725	COG0750	zinc metalloprotease
A6J72_RS06730	COG0442	prolyl-tRNA aminoacylation
A6J72_RS06790	COG0285	dihydrofolate synthase activity
A6J72_RS06850	COG1363	Peptidase, m42
A6J72_RS06860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6J72_RS06865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J72_RS06880	COG4585	Histidine kinase
A6J72_RS06885	COG2197	response regulator
A6J72_RS06905	COG3715	PTS system
A6J72_RS06910	COG3716	PTS system mannose fructose sorbose family IID component
A6J72_RS06925	COG0459	protein refolding
A6J72_RS06945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J72_RS06970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J72_RS07005	COG3590	peptidase
A6J72_RS07015	COG1523	belongs to the glycosyl hydrolase 13 family
A6J72_RS07020	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6J72_RS07025	COG2176	DNA-directed DNA polymerase activity
A6J72_RS07030	COG2309	aminopeptidase activity
A6J72_RS07095	COG1187	pseudouridine synthase activity
A6J72_RS07110	COG1164	Oligoendopeptidase f
A6J72_RS07115	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J72_RS07120	COG1045	serine acetyltransferase
A6J72_RS07130	COG0215	cysteine-tRNA ligase activity
A6J72_RS07135	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A6J72_RS07145	COG3842	ATPase activity
A6J72_RS07165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J72_RS07170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6J72_RS07195	COG1674	ftsk spoiiie
A6J72_RS07230	COG2946	Replication initiation factor
A6J72_RS07270	COG1132	(ABC) transporter
A6J72_RS07275	COG2184	nucleotidyltransferase activity
A6J72_RS07305	COG2217	Heavy metal translocating P-type atpase
A6J72_RS07340	COG1131	(ABC) transporter
A6J72_RS07395	COG0386	Belongs to the glutathione peroxidase family
A6J72_RS07400	COG5492	domain, Protein
A6J72_RS07425	COG1028	Short-chain dehydrogenase reductase Sdr
A6J72_RS07435	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A6J72_RS07440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J72_RS07445	COG3715	PTS system
A6J72_RS07450	COG3716	PTS system mannose fructose sorbose family IID component
A6J72_RS07465	COG1609	Transcriptional regulator
A6J72_RS07470	COG3830	Belongs to the UPF0237 family
A6J72_RS07475	COG2848	UPF0210 protein
A6J72_RS07490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J72_RS07500	COG3037	sugar-specific permease SgaT UlaA
A6J72_RS07505	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6J72_RS07510	COG1420	regulation of RNA biosynthetic process
A6J72_RS07515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6J72_RS07525	COG0484	heat shock protein binding
A6J72_RS07535	COG0101	tRNA pseudouridine synthase activity
A6J72_RS07540	COG0351	phosphomethylpyrimidine kinase
A6J72_RS07545	COG4720	Psort location CytoplasmicMembrane, score
A6J72_RS07550	COG4475	Protein of unknown function (DUF436)
A6J72_RS07555	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6J72_RS07560	COG3343	RNA polymerase activity
A6J72_RS07565	COG0504	CTP synthase activity
A6J72_RS07580	COG4166	transmembrane transport
A6J72_RS07585	COG4166	transmembrane transport
A6J72_RS07590	COG0601	transmembrane transport
A6J72_RS07595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J72_RS07600	COG0444	Belongs to the ABC transporter superfamily
A6J72_RS07605	COG4608	Belongs to the ABC transporter superfamily
A6J72_RS07610	COG0561	phosphatase activity
A6J72_RS07615	COG1609	Transcriptional regulator
A6J72_RS07620	COG1621	beta-fructofuranosidase activity
A6J72_RS07630	COG2190	(PTS) system
A6J72_RS07630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J72_RS07630	COG1263	PTS System
A6J72_RS07635	COG1940	carbohydrate kinase activity
A6J72_RS07640	COG0242	peptide deformylase activity
A6J72_RS07645	COG1902	pentaerythritol trinitrate reductase activity
A6J72_RS07660	COG1132	(ABC) transporter
A6J72_RS07670	COG2723	6-phospho-beta-galactosidase activity
A6J72_RS07675	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J72_RS07680	COG2188	Transcriptional regulator
A6J72_RS07685	COG1482	cell wall glycoprotein biosynthetic process
A6J72_RS07690	COG0531	amino acid
A6J72_RS07700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6J72_RS07705	COG0736	holo-[acyl-carrier-protein] synthase activity
A6J72_RS07710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J72_RS07715	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J72_RS07720	COG0252	asparaginase activity
A6J72_RS07725	COG0561	phosphatase activity
A6J72_RS07730	COG0589	response to stress
A6J72_RS07735	COG0436	Aminotransferase
A6J72_RS07740	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A6J72_RS07745	COG1335	isochorismatase
A6J72_RS07750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6J72_RS07755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6J72_RS07760	COG0154	amidase activity
A6J72_RS07765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6J72_RS07770	COG1063	alcohol dehydrogenase
A6J72_RS07785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A6J72_RS07790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6J72_RS07795	COG1534	Rna-binding protein
A6J72_RS07800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6J72_RS07805	COG1713	HD superfamily hydrolase involved in NAD metabolism
A6J72_RS07815	COG0799	negative regulation of ribosome biogenesis
A6J72_RS07825	COG2226	methyltransferase
A6J72_RS07830	COG1323	Belongs to the UPF0348 family
A6J72_RS07845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J72_RS07850	COG1464	Belongs to the NlpA lipoprotein family
A6J72_RS07855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J72_RS07860	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J72_RS07950	COG4720	Psort location CytoplasmicMembrane, score
A6J72_RS07980	COG1122	ATPase activity
A6J72_RS07995	COG1442	glycosyl transferase family 8
A6J72_RS08005	COG0357	Ribosomal RNA small subunit methyltransferase G
A6J72_RS08010	COG1704	LemA family
A6J72_RS08015	COG0501	Belongs to the peptidase M48B family
A6J72_RS08045	COG1131	(ABC) transporter
A6J72_RS08055	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6J72_RS08060	COG0745	RESPONSE REGULATOR receiver
A6J72_RS08065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J72_RS08065	COG1263	PTS System
A6J72_RS08065	COG2190	(PTS) system
A6J72_RS08070	COG2190	(PTS) system
A6J72_RS08070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6J72_RS08070	COG1263	PTS System
A6J72_RS08085	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6J72_RS08095	COG1484	DNA-dependent DNA replication
A6J72_RS08130	COG1160	GTP binding
A6J72_RS08135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6J72_RS08145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J72_RS08160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6J72_RS08180	COG1254	Belongs to the acylphosphatase family
A6J72_RS08185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J72_RS08210	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J72_RS08215	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6J72_RS08225	COG0517	IMP dehydrogenase activity
A6J72_RS08230	COG4974	Belongs to the 'phage' integrase family
A6J72_RS08235	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6J72_RS08245	COG1187	pseudouridine synthase activity
A6J72_RS08255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J72_RS08260	COG0569	domain protein
A6J72_RS08270	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A6J72_RS08275	COG0671	phosphoesterase, PA-phosphatase related
A6J72_RS08285	COG1242	4 iron, 4 sulfur cluster binding
A6J72_RS08290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6J72_RS08300	COG0025	NhaP-type Na H and K H
A6J72_RS08310	COG0494	nUDIX hydrolase
A6J72_RS08315	COG2378	regulation of single-species biofilm formation
A6J72_RS08325	COG0542	response to heat
A6J72_RS08330	COG4703	Protein of unknown function (DUF1797)
A6J72_RS08350	COG1136	(ABC) transporter
A6J72_RS08355	COG0577	efflux transmembrane transporter activity
A6J72_RS08360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6J72_RS08365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6J72_RS08370	COG1570	exodeoxyribonuclease VII activity
A6J72_RS08375	COG1722	exodeoxyribonuclease VII activity
A6J72_RS08385	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6J72_RS08390	COG1438	arginine binding
A6J72_RS08395	COG0497	DNA recombination
A6J72_RS08400	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6J72_RS08410	COG4604	ABC transporter, ATP-binding protein
A6J72_RS08415	COG4605	iron ion homeostasis
A6J72_RS08420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J72_RS08425	COG1307	EDD domain protein, DegV family
A6J72_RS08435	COG0735	belongs to the Fur family
A6J72_RS08440	COG0588	phosphoglycerate mutase activity
A6J72_RS08445	COG0768	penicillin binding
A6J72_RS08450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6J72_RS08465	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J72_RS08470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J72_RS08500	COG3620	sequence-specific DNA binding
A6J72_RS08510	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6J72_RS08525	COG0513	Belongs to the DEAD box helicase family
A6J72_RS08540	COG0698	ribose 5-phosphate isomerase
A6J72_RS08560	COG3775	system Galactitol-specific IIC component
A6J72_RS08565	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J72_RS08570	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A6J72_RS08570	COG3583	domain protein
A6J72_RS08570	COG3064	Membrane
A6J72_RS08575	COG3711	transcriptional antiterminator
A6J72_RS08580	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6J72_RS08585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J72_RS08585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6J72_RS08590	COG2723	6-phospho-beta-galactosidase activity
A6J72_RS08595	COG1755	Isoprenylcysteine carboxyl methyltransferase
A6J72_RS08600	COG2827	Endonuclease containing a URI domain
A6J72_RS08605	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6J72_RS08610	COG0254	rRNA binding
A6J72_RS08615	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6J72_RS08620	COG0716	FMN binding
A6J72_RS08630	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A6J72_RS08635	COG1518	maintenance of DNA repeat elements
A6J72_RS08640	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A6J72_RS08650	COG0628	permease
A6J72_RS08660	COG0028	Belongs to the TPP enzyme family
A6J72_RS08665	COG3527	Alpha-acetolactate decarboxylase
A6J72_RS08670	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A6J72_RS08685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J72_RS08695	COG4443	Transcriptional Coactivator p15 (PC4)
A6J72_RS08740	COG4152	abc transporter atp-binding protein
A6J72_RS08745	COG1668	transmembrane transport
A6J72_RS08750	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A6J72_RS08755	COG1074	ATP-dependent DNA helicase activity
A6J72_RS08760	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A6J72_RS08770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A6J72_RS08775	COG0297	glycogen (starch) synthase activity
A6J72_RS08780	COG0058	SHG alpha-glucan phosphorylase activity
A6J72_RS08825	COG0356	it plays a direct role in the translocation of protons across the membrane
A6J72_RS08830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6J72_RS08835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J72_RS08840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6J72_RS08845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6J72_RS08865	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J72_RS08885	COG1132	(ABC) transporter
A6J72_RS08910	COG1346	cytolysis
A6J72_RS08915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J72_RS08930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J72_RS08935	COG0492	ferredoxin-NADP+ reductase activity
A6J72_RS08945	COG1349	DNA-binding transcription factor activity
A6J72_RS08950	COG1105	Belongs to the carbohydrate kinase PfkB family
A6J72_RS08955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6J72_RS08955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J72_RS08955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6J72_RS08965	COG1307	EDD domain protein, DegV family
A6J72_RS08970	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6J72_RS08975	COG0617	tRNA 3'-terminal CCA addition
A6J72_RS08980	COG0488	(ABC) transporter
A6J72_RS08995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J72_RS08995	COG0072	phenylalanine-tRNA ligase activity
A6J72_RS09000	COG1268	BioY protein
A6J72_RS09005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6J72_RS09010	COG0577	efflux transmembrane transporter activity
A6J72_RS09020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6J72_RS09025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6J72_RS09045	COG0300	oxidoreductase activity
A6J72_RS09060	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6J72_RS09060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6J72_RS09080	COG0205	6-phosphofructokinase activity
A6J72_RS09085	COG0469	pyruvate kinase activity
A6J72_RS09095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J72_RS09100	COG0210	DNA helicase
A6J72_RS09105	COG0494	nUDIX hydrolase
A6J72_RS09120	COG2375	cellular response to nickel ion
A6J72_RS09120	COG1132	(ABC) transporter
A6J72_RS09125	COG1132	(ABC) transporter
A6J72_RS09155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6J72_RS09160	COG0196	riboflavin kinase activity
A6J72_RS09165	COG1393	Belongs to the ArsC family
A6J72_RS09170	COG4476	Belongs to the UPF0223 family
A6J72_RS09175	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A6J72_RS09175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6J72_RS09185	COG0573	inorganic phosphate transmembrane transporter activity
A6J72_RS09190	COG0581	inorganic phosphate transmembrane transporter activity
A6J72_RS09195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J72_RS09200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J72_RS09205	COG0704	Plays a role in the regulation of phosphate uptake
A6J72_RS09210	COG2003	Belongs to the UPF0758 family
A6J72_RS09230	COG1104	cysteine desulfurase activity
A6J72_RS09235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J72_RS09245	COG2357	RelA SpoT domain protein
A6J72_RS09255	COG0564	pseudouridine synthase activity
A6J72_RS09260	COG0280	phosphate acetyltransferase
A6J72_RS09265	COG1194	a g-specific adenine glycosylase
A6J72_RS09280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J72_RS09285	COG4684	Psort location CytoplasmicMembrane, score
A6J72_RS09290	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6J72_RS09305	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A6J72_RS09320	COG0583	DNA-binding transcription factor activity
A6J72_RS09330	COG0281	malic enzyme
A6J72_RS09380	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6J72_RS09385	COG0477	Major facilitator Superfamily
A6J72_RS09390	COG3689	TIGRFAM TIGR03943 family protein
A6J72_RS09395	COG0701	Predicted permease
A6J72_RS09405	COG2183	response to ionizing radiation
A6J72_RS09410	COG3091	SprT-like family
A6J72_RS09425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A6J72_RS09430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6J72_RS09455	COG0826	peptidase U32
A6J72_RS09480	COG0488	(ABC) transporter
A6J72_RS09505	COG3442	glutamine amidotransferase
A6J72_RS09510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6J72_RS09515	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A6J72_RS09525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J72_RS09530	COG0560	Phosphoserine phosphatase
A6J72_RS09555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6J72_RS09565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6J72_RS09580	COG0726	polysaccharide deacetylase
A6J72_RS09590	COG0673	inositol 2-dehydrogenase activity
A6J72_RS09595	COG0572	uridine kinase
A6J72_RS09600	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J72_RS09610	COG0561	phosphatase activity
A6J72_RS09615	COG0481	GTPase activity
A6J72_RS09620	COG0812	UDP-N-acetylmuramate dehydrogenase activity