locus-tag	class	description
SITYG_RS00010	COG0592	DNA-directed DNA polymerase activity
SITYG_RS00025	COG0012	GTP binding
SITYG_RS00030	COG0193	aminoacyl-tRNA hydrolase activity
SITYG_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SITYG_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SITYG_RS00060	COG0037	tRNA processing
SITYG_RS00065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SITYG_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SITYG_RS00190	COG1792	Involved in formation and maintenance of cell shape
SITYG_RS00200	COG3942	CHAP domain
SITYG_RS00205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SITYG_RS00210	COG0436	Aminotransferase
SITYG_RS00215	COG1381	Involved in DNA repair and RecF pathway recombination
SITYG_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SITYG_RS00230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SITYG_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SITYG_RS00245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SITYG_RS00250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SITYG_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SITYG_RS00260	COG2176	DNA-directed DNA polymerase activity
SITYG_RS00270	COG0138	bifunctional purine biosynthesis protein purh
SITYG_RS00275	COG3942	CHAP domain
SITYG_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SITYG_RS00335	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SITYG_RS00350	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SITYG_RS00360	COG3716	PTS system mannose fructose sorbose family IID component
SITYG_RS00370	COG2222	sugar isomerase
SITYG_RS00390	COG2255	four-way junction helicase activity
SITYG_RS00510	COG0551	DNA topoisomerase type I activity
SITYG_RS00510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SITYG_RS00515	COG0542	response to heat
SITYG_RS00655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SITYG_RS00670	COG1454	alcohol dehydrogenase
SITYG_RS00670	COG1012	belongs to the aldehyde dehydrogenase family
SITYG_RS00675	COG4842	Belongs to the WXG100 family
SITYG_RS00690	COG4499	WXG100 protein secretion system (Wss), protein YukC
SITYG_RS00695	COG1674	ftsk spoiiie
SITYG_RS00885	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SITYG_RS00895	COG1175	transmembrane transport
SITYG_RS00900	COG0395	ABC-type sugar transport system, permease component
SITYG_RS00905	COG2731	YhcH YjgK YiaL family protein
SITYG_RS00915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SITYG_RS00935	COG1263	PTS System
SITYG_RS00935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SITYG_RS00940	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SITYG_RS00955	COG1269	ATP hydrolysis coupled proton transport
SITYG_RS00960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SITYG_RS00970	COG1527	subunit (C
SITYG_RS00980	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SITYG_RS00985	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SITYG_RS00990	COG1394	ATPase activity, coupled to movement of substances
SITYG_RS01000	COG0534	Mate efflux family protein
SITYG_RS01015	COG4932	domain protein
SITYG_RS01015	COG1388	LysM domain
SITYG_RS01030	COG1846	Transcriptional regulator
SITYG_RS01035	COG1121	(ABC) transporter
SITYG_RS01040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SITYG_RS01045	COG0803	Belongs to the bacterial solute-binding protein 9 family
SITYG_RS01045	COG3443	Belongs to the bacterial solute-binding protein 9 family
SITYG_RS01055	COG2217	Heavy metal translocating P-type atpase
SITYG_RS01065	COG0564	pseudouridine synthase activity
SITYG_RS01070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SITYG_RS01075	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SITYG_RS01100	COG0052	Belongs to the universal ribosomal protein uS2 family
SITYG_RS01105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SITYG_RS01115	COG4463	regulation of RNA biosynthetic process
SITYG_RS01130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SITYG_RS01135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SITYG_RS01155	COG1396	sequence-specific DNA binding
SITYG_RS01200	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SITYG_RS01235	COG0166	Belongs to the GPI family
SITYG_RS01245	COG0594	ribonuclease P activity
SITYG_RS01270	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SITYG_RS01275	COG0084	hydrolase, TatD family'
SITYG_RS01295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SITYG_RS01310	COG1162	GTPase activity
SITYG_RS01320	COG1564	THIamine pyrophosphokinase
SITYG_RS01330	COG3481	metal-dependent phosphohydrolase, HD sub domain
SITYG_RS01335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SITYG_RS01345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SITYG_RS01350	COG0049	tRNA binding
SITYG_RS01355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SITYG_RS01375	COG1214	PFAM Peptidase M22, glycoprotease
SITYG_RS01385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SITYG_RS01400	COG1396	sequence-specific DNA binding
SITYG_RS01430	COG0789	Transcriptional regulator
SITYG_RS01440	COG2081	HI0933 family
SITYG_RS01455	COG0584	glycerophosphoryl diester phosphodiesterase
SITYG_RS01460	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SITYG_RS01465	COG2936	dipeptidyl-peptidase activity
SITYG_RS01470	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SITYG_RS01505	COG1304	FMN binding
SITYG_RS01515	COG3425	synthase
SITYG_RS01530	COG1882	Formate acetyltransferase
SITYG_RS01540	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SITYG_RS01545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SITYG_RS01550	COG0681	Belongs to the peptidase S26 family
SITYG_RS01570	COG1193	negative regulation of DNA recombination
SITYG_RS01580	COG3118	belongs to the thioredoxin family
SITYG_RS01585	COG0531	amino acid
SITYG_RS01590	COG0668	transmembrane transport
SITYG_RS01600	COG5504	Zn-dependent protease
SITYG_RS01610	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SITYG_RS01615	COG0167	dihydroorotate dehydrogenase activity
SITYG_RS01620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SITYG_RS01620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SITYG_RS01625	COG0402	S-adenosylhomocysteine deaminase activity
SITYG_RS01635	COG1940	carbohydrate kinase activity
SITYG_RS01640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SITYG_RS01655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SITYG_RS01660	COG1447	Phosphotransferase system cellobiose-specific component IIA
SITYG_RS01665	COG1309	transcriptional regulator
SITYG_RS01690	COG0346	lactoylglutathione lyase activity
SITYG_RS01705	COG1401	restriction endodeoxyribonuclease activity
SITYG_RS01725	COG0745	RESPONSE REGULATOR receiver
SITYG_RS01730	COG5002	protein histidine kinase activity
SITYG_RS01745	COG0366	Alpha amylase catalytic
SITYG_RS01755	COG1122	ATPase activity
SITYG_RS01765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SITYG_RS01775	COG2134	cdp-diacylglycerol pyrophosphatase
SITYG_RS01810	COG0629	single-stranded DNA binding
SITYG_RS01815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SITYG_RS01835	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SITYG_RS01845	COG0006	proline dipeptidase activity
SITYG_RS01850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SITYG_RS01895	COG0527	aspartate kinase activity
SITYG_RS01900	COG1024	Enoyl-CoA hydratase
SITYG_RS01910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SITYG_RS01920	COG2070	2-Nitropropane dioxygenase
SITYG_RS01925	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SITYG_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
SITYG_RS01935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SITYG_RS01945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SITYG_RS01950	COG0439	Biotin carboxylase
SITYG_RS01955	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SITYG_RS01960	COG0825	malonyl-CoA metabolic process
SITYG_RS01965	COG0586	Pfam SNARE associated Golgi protein
SITYG_RS01980	COG3716	PTS system mannose fructose sorbose family IID component
SITYG_RS01985	COG3715	PTS system
SITYG_RS01995	COG1064	alcohol dehydrogenase
SITYG_RS02000	COG0561	phosphatase activity
SITYG_RS02010	COG2252	PERMEase
SITYG_RS02020	COG0802	atpase or kinase
SITYG_RS02030	COG1316	TRANSCRIPTIONal
SITYG_RS02040	COG0537	adenosine 5'-monophosphoramidase activity
SITYG_RS02045	COG1131	(ABC) transporter
SITYG_RS02055	COG0510	thiamine kinase activity
SITYG_RS02060	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SITYG_RS02070	COG0779	Required for maturation of 30S ribosomal subunits
SITYG_RS02075	COG0195	Participates in both transcription termination and antitermination
SITYG_RS02080	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SITYG_RS02095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SITYG_RS02100	COG1283	sodium-dependent phosphate transmembrane transporter activity
SITYG_RS02125	COG1673	EVE domain
SITYG_RS02130	COG0752	glycyl-tRNA synthetase alpha subunit
SITYG_RS02135	COG0751	glycine-tRNA ligase activity
SITYG_RS02150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SITYG_RS02175	COG0768	penicillin binding
SITYG_RS02180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SITYG_RS02185	COG4166	transmembrane transport
SITYG_RS02195	COG0504	CTP synthase activity
SITYG_RS02210	COG0191	fructose-bisphosphate aldolase activity
SITYG_RS02230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SITYG_RS02240	COG1461	Dihydroxyacetone kinase
SITYG_RS02245	COG1131	(ABC) transporter
SITYG_RS02250	COG0842	Transport permease protein
SITYG_RS02255	COG4585	Histidine kinase
SITYG_RS02260	COG2197	response regulator
SITYG_RS02275	COG1126	abc transporter atp-binding protein
SITYG_RS02280	COG0765	amino acid transport
SITYG_RS02290	COG1968	undecaprenyl-diphosphatase activity
SITYG_RS02295	COG4862	establishment of competence for transformation
SITYG_RS02300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SITYG_RS02310	COG0719	Fe-S assembly protein
SITYG_RS02315	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SITYG_RS02325	COG1686	Belongs to the peptidase S11 family
SITYG_RS02330	COG0513	Belongs to the DEAD box helicase family
SITYG_RS02340	COG1126	abc transporter atp-binding protein
SITYG_RS02350	COG0492	ferredoxin-NADP+ reductase activity
SITYG_RS02355	COG1113	amino acid transport
SITYG_RS02370	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SITYG_RS02375	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SITYG_RS02380	COG3579	cysteine-type endopeptidase activity
SITYG_RS02385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SITYG_RS02390	COG3331	DNA recombination
SITYG_RS02395	COG4474	Belongs to the UPF0398 family
SITYG_RS02400	COG3599	regulation of cell shape
SITYG_RS02410	COG0116	Belongs to the methyltransferase superfamily
SITYG_RS02420	COG0450	alkyl hydroperoxide reductase
SITYG_RS02425	COG3634	alkyl hydroperoxide reductase activity
SITYG_RS02435	COG1418	mRNA catabolic process
SITYG_RS02440	COG0194	GDP metabolic process
SITYG_RS02445	COG1758	RNA polymerase activity
SITYG_RS02450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SITYG_RS02455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SITYG_RS02460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SITYG_RS02460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SITYG_RS02465	COG0631	protein serine/threonine phosphatase activity
SITYG_RS02470	COG2815	serine threonine protein kinase
SITYG_RS02470	COG0515	serine threonine protein kinase
SITYG_RS02480	COG4585	Histidine kinase
SITYG_RS02495	COG1185	polyribonucleotide nucleotidyltransferase activity
SITYG_RS02505	COG3557	Belongs to the UPF0374 family
SITYG_RS02510	COG2137	regulation of response to DNA damage stimulus
SITYG_RS02515	COG3231	kanamycin kinase activity
SITYG_RS02520	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SITYG_RS02550	COG0519	Catalyzes the synthesis of GMP from XMP
SITYG_RS02560	COG0525	valine-tRNA ligase activity
SITYG_RS02595	COG1739	Uncharacterized protein family UPF0029
SITYG_RS02600	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SITYG_RS02605	COG1040	competence protein
SITYG_RS02615	COG0742	ribosomal rna small subunit methyltransferase
SITYG_RS02620	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SITYG_RS02625	COG3480	Lon protease (S16) C-terminal proteolytic domain
SITYG_RS02630	COG4470	Protein conserved in bacteria
SITYG_RS02635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SITYG_RS02645	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SITYG_RS02665	COG1187	pseudouridine synthase activity
SITYG_RS02670	COG1217	gtp-binding protein TYPA
SITYG_RS02680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SITYG_RS02685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SITYG_RS02690	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SITYG_RS02705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SITYG_RS02710	COG1799	cell septum assembly
SITYG_RS02725	COG3599	regulation of cell shape
SITYG_RS02730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SITYG_RS02740	COG0628	permease
SITYG_RS02750	COG1253	flavin adenine dinucleotide binding
SITYG_RS02755	COG2188	Transcriptional regulator
SITYG_RS02760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SITYG_RS02760	COG1263	PTS System
SITYG_RS02765	COG0366	Alpha amylase catalytic
SITYG_RS02775	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SITYG_RS02805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SITYG_RS02810	COG2244	polysaccharide biosynthetic process
SITYG_RS02820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SITYG_RS02825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SITYG_RS02830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SITYG_RS02835	COG0740	serine-type endopeptidase activity
SITYG_RS02840	COG4471	UPF0298 protein
SITYG_RS02850	COG0559	Belongs to the binding-protein-dependent transport system permease family
SITYG_RS02870	COG0517	IMP dehydrogenase activity
SITYG_RS02875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SITYG_RS02880	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SITYG_RS02885	COG0470	DNA polymerase III
SITYG_RS02890	COG4467	Involved in initiation control of chromosome replication
SITYG_RS02900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SITYG_RS02905	COG1393	Belongs to the ArsC family
SITYG_RS02910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SITYG_RS02920	COG0708	Exodeoxyribonuclease III
SITYG_RS02935	COG0640	Transcriptional regulator
SITYG_RS02965	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SITYG_RS02965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SITYG_RS02975	COG0745	RESPONSE REGULATOR receiver
SITYG_RS02990	COG1136	(ABC) transporter
SITYG_RS02995	COG0577	efflux transmembrane transporter activity
SITYG_RS03010	COG3279	Response regulator of the LytR AlgR family
SITYG_RS03025	COG1136	(ABC) transporter
SITYG_RS03030	COG0577	efflux transmembrane transporter activity
SITYG_RS03035	COG0531	amino acid
SITYG_RS03065	COG1028	Short-chain dehydrogenase reductase Sdr
SITYG_RS03090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SITYG_RS03105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SITYG_RS03115	COG0488	(ABC) transporter
SITYG_RS03130	COG1983	PspC domain protein
SITYG_RS03135	COG0697	spore germination
SITYG_RS03135	COG1674	ftsk spoiiie
SITYG_RS03140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SITYG_RS03150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SITYG_RS03155	COG0081	regulation of translation
SITYG_RS03160	COG0528	UMP kinase activity
SITYG_RS03165	COG0233	cytoplasmic translational termination
SITYG_RS03170	COG2996	Protein conserved in bacteria
SITYG_RS03180	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SITYG_RS03195	COG2274	protein secretion by the type I secretion system
SITYG_RS03200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SITYG_RS03290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SITYG_RS03295	COG0549	Belongs to the carbamate kinase family
SITYG_RS03300	COG1288	antiporter activity
SITYG_RS03305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SITYG_RS03310	COG1438	arginine binding
SITYG_RS03315	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SITYG_RS03320	COG0363	glucosamine-6-phosphate deaminase activity
SITYG_RS03335	COG2723	6-phospho-beta-galactosidase activity
SITYG_RS03340	COG4095	Psort location CytoplasmicMembrane, score
SITYG_RS03350	COG3711	transcriptional antiterminator
SITYG_RS03350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SITYG_RS03355	COG1447	Phosphotransferase system cellobiose-specific component IIA
SITYG_RS03365	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SITYG_RS03380	COG4122	O-methyltransferase activity
SITYG_RS03385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SITYG_RS03400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SITYG_RS03405	COG3842	ATPase activity
SITYG_RS03415	COG2348	transferase activity, transferring amino-acyl groups
SITYG_RS03425	COG1078	dGTPase activity
SITYG_RS03445	COG2884	Cell division ATP-binding protein ftsE
SITYG_RS03450	COG2177	Part of the ABC transporter FtsEX involved in
SITYG_RS03460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SITYG_RS03460	COG1199	ATP-dependent helicase activity
SITYG_RS03470	COG0772	Belongs to the SEDS family
SITYG_RS03475	COG0693	protein deglycase activity
SITYG_RS03485	COG0187	DNA topoisomerase II activity
SITYG_RS03490	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SITYG_RS03495	COG2706	6-phosphogluconolactonase activity
SITYG_RS03500	COG0745	RESPONSE REGULATOR receiver
SITYG_RS03505	COG3850	Histidine kinase
SITYG_RS03505	COG5002	protein histidine kinase activity
SITYG_RS03520	COG1309	transcriptional regulator
SITYG_RS03545	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SITYG_RS03550	COG1349	DNA-binding transcription factor activity
SITYG_RS03560	COG1447	Phosphotransferase system cellobiose-specific component IIA
SITYG_RS03570	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SITYG_RS03575	COG1882	Formate acetyltransferase
SITYG_RS03635	COG3537	Alpha-1,2-mannosidase
SITYG_RS03645	COG0383	alpha-mannosidase activity
SITYG_RS03660	COG4209	transmembrane transport
SITYG_RS03665	COG0395	ABC-type sugar transport system, permease component
SITYG_RS03670	COG1653	transport
SITYG_RS03680	COG2972	Histidine kinase
SITYG_RS03685	COG2207	Transcriptional regulator
SITYG_RS03685	COG4753	response regulator
SITYG_RS03695	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SITYG_RS03710	COG4974	Belongs to the 'phage' integrase family
SITYG_RS03715	COG0732	type I restriction modification DNA specificity domain
SITYG_RS03730	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SITYG_RS03735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SITYG_RS03740	COG0406	alpha-ribazole phosphatase activity
SITYG_RS03745	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SITYG_RS03755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SITYG_RS03760	COG0204	Acyl-transferase
SITYG_RS03795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SITYG_RS03805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SITYG_RS03810	COG0322	excinuclease ABC activity
SITYG_RS03820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SITYG_RS03835	COG1573	uracil-dna glycosylase
SITYG_RS03845	COG1174	glycine betaine transport
SITYG_RS03850	COG1125	glycine betaine transport
SITYG_RS03865	COG0772	Belongs to the SEDS family
SITYG_RS03870	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SITYG_RS03875	COG1191	sigma factor activity
SITYG_RS03885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SITYG_RS03915	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SITYG_RS03920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SITYG_RS03940	COG1368	sulfuric ester hydrolase activity
SITYG_RS03945	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SITYG_RS03950	COG0710	3-dehydroquinate dehydratase activity
SITYG_RS03955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SITYG_RS03960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SITYG_RS03965	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SITYG_RS03970	COG0730	response to heat
SITYG_RS03980	COG0287	Prephenate dehydrogenase
SITYG_RS03985	COG3679	Belongs to the UPF0342 family
SITYG_RS03995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SITYG_RS04005	COG0077	Prephenate dehydratase
SITYG_RS04015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SITYG_RS04025	COG0477	Major facilitator Superfamily
SITYG_RS04040	COG0656	L-ascorbic acid biosynthetic process
SITYG_RS04060	COG1132	(ABC) transporter
SITYG_RS04135	COG1442	glycosyl transferase family 8
SITYG_RS04135	COG1216	Glycosyl transferase, family 2
SITYG_RS04150	COG0463	Glycosyl transferase, family 2
SITYG_RS04155	COG1091	dTDP-4-dehydrorhamnose reductase activity
SITYG_RS04195	COG2384	SAM-dependent methyltransferase
SITYG_RS04200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SITYG_RS04205	COG0494	nUDIX hydrolase
SITYG_RS04210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SITYG_RS04220	COG1088	dTDP-glucose 4,6-dehydratase activity
SITYG_RS04225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SITYG_RS04230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SITYG_RS04235	COG0006	proline dipeptidase activity
SITYG_RS04240	COG1609	Transcriptional regulator
SITYG_RS04250	COG0438	transferase activity, transferring glycosyl groups
SITYG_RS04260	COG0745	RESPONSE REGULATOR receiver
SITYG_RS04265	COG5002	protein histidine kinase activity
SITYG_RS04270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SITYG_RS04275	COG2832	Protein of unknown function (DUF454)
SITYG_RS04280	COG0571	ribonuclease III activity
SITYG_RS04285	COG1196	nuclear chromosome segregation
SITYG_RS04290	COG0561	phosphatase activity
SITYG_RS04295	COG0561	phosphatase activity
SITYG_RS04300	COG0552	protein localization to endoplasmic reticulum
SITYG_RS04310	COG0574	Belongs to the PEP-utilizing enzyme family
SITYG_RS04310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SITYG_RS04315	COG0517	IMP dehydrogenase activity
SITYG_RS04320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SITYG_RS04325	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SITYG_RS04330	COG1104	cysteine desulfurase activity
SITYG_RS04335	COG0301	tRNA thio-modification
SITYG_RS04345	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SITYG_RS04355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SITYG_RS04365	COG0446	pyridine nucleotide-disulphide oxidoreductase
SITYG_RS04390	COG0583	DNA-binding transcription factor activity
SITYG_RS04395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SITYG_RS04400	COG0564	pseudouridine synthase activity
SITYG_RS04405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SITYG_RS04415	COG2824	Alkylphosphonate utilization operon protein PhnA
SITYG_RS04435	COG0038	chloride channel
SITYG_RS04440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SITYG_RS04450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SITYG_RS04460	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SITYG_RS04465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SITYG_RS04470	COG1388	LysM domain
SITYG_RS04470	COG1705	Flagellar rod assembly protein muramidase FlgJ
SITYG_RS04485	COG1132	(ABC) transporter
SITYG_RS04490	COG0488	(ABC) transporter
SITYG_RS04505	COG0556	nucleotide-excision repair
SITYG_RS04525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SITYG_RS04535	COG1051	belongs to the nudix hydrolase family
SITYG_RS04540	COG0647	UMP catabolic process
SITYG_RS04560	COG1660	Displays ATPase and GTPase activities
SITYG_RS04565	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SITYG_RS04570	COG1481	regulation of sporulation
SITYG_RS04580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SITYG_RS04590	COG0540	Belongs to the ATCase OTCase family
SITYG_RS04595	COG0505	Belongs to the CarA family
SITYG_RS04600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SITYG_RS04605	COG1940	carbohydrate kinase activity
SITYG_RS04660	COG0745	RESPONSE REGULATOR receiver
SITYG_RS04665	COG5002	protein histidine kinase activity
SITYG_RS04685	COG1072	(Pantothenic acid kinase))
SITYG_RS04690	COG2813	Specifically methylates the guanine in position
SITYG_RS04700	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SITYG_RS04705	COG0295	cytidine deaminase activity
SITYG_RS04710	COG1744	ABC transporter substrate-binding protein PnrA-like
SITYG_RS04715	COG3845	ABC transporter
SITYG_RS04720	COG4603	Belongs to the binding-protein-dependent transport system permease family
SITYG_RS04725	COG1079	Belongs to the binding-protein-dependent transport system permease family
SITYG_RS04730	COG1272	protein, Hemolysin III
SITYG_RS04740	COG3022	response to hydroperoxide
SITYG_RS04750	COG1846	Transcriptional regulator
SITYG_RS04760	COG0436	Aminotransferase
SITYG_RS04770	COG0017	Asparaginyl-tRNA synthetase
SITYG_RS04775	COG2814	Major facilitator Superfamily
SITYG_RS04830	COG1309	transcriptional regulator
SITYG_RS04835	COG2131	deaminase
SITYG_RS04845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SITYG_RS04850	COG0187	DNA topoisomerase II activity
SITYG_RS04870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SITYG_RS04875	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SITYG_RS04895	COG0539	negative regulation of cytoplasmic translation
SITYG_RS04905	COG0494	nUDIX hydrolase
SITYG_RS04910	COG0039	L-malate dehydrogenase activity
SITYG_RS04915	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SITYG_RS04920	COG3764	Sortase (surface protein transpeptidase)
SITYG_RS04925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SITYG_RS04930	COG1970	mechanosensitive ion channel activity
SITYG_RS04935	COG0358	DNA primase activity
SITYG_RS04940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SITYG_RS04945	COG2151	metal-sulfur cluster biosynthetic enzyme
SITYG_RS04955	COG0785	Cytochrome C biogenesis protein
SITYG_RS04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SITYG_RS04965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SITYG_RS04965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SITYG_RS04970	COG2207	Transcriptional regulator
SITYG_RS04970	COG4753	response regulator
SITYG_RS04975	COG2972	Histidine kinase
SITYG_RS04990	COG4555	ABC transporter
SITYG_RS04995	COG3976	FMN-binding domain protein
SITYG_RS04995	COG1053	succinate dehydrogenase
SITYG_RS04995	COG0431	NADPH-dependent FMN reductase
SITYG_RS05035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SITYG_RS05040	COG2233	PERMEase
SITYG_RS05045	COG0534	Mate efflux family protein
SITYG_RS05050	COG1942	4-Oxalocrotonate Tautomerase
SITYG_RS05055	COG1435	thymidine kinase activity
SITYG_RS05060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SITYG_RS05065	COG2890	protein-(glutamine-N5) methyltransferase activity
SITYG_RS05070	COG0009	L-threonylcarbamoyladenylate synthase
SITYG_RS05075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SITYG_RS05085	COG0741	lytic transglycosylase activity
SITYG_RS05100	COG2188	Transcriptional regulator
SITYG_RS05110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SITYG_RS05115	COG4974	Belongs to the 'phage' integrase family
SITYG_RS05135	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SITYG_RS05140	COG0135	phosphoribosylanthranilate isomerase activity
SITYG_RS05145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SITYG_RS05150	COG0758	DNA mediated transformation
SITYG_RS05285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SITYG_RS05300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SITYG_RS05315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SITYG_RS05320	COG1132	(ABC) transporter
SITYG_RS05325	COG1132	(ABC) transporter
SITYG_RS05330	COG2315	Protein conserved in bacteria
SITYG_RS05335	COG3142	Participates in the control of copper homeostasis
SITYG_RS05350	COG1827	regulation of RNA biosynthetic process
SITYG_RS05355	COG1837	Belongs to the UPF0109 family
SITYG_RS05360	COG0228	four-way junction DNA binding
SITYG_RS05365	COG1523	belongs to the glycosyl hydrolase 13 family
SITYG_RS05370	COG1597	lipid kinase activity
SITYG_RS05375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SITYG_RS05380	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SITYG_RS05390	COG4708	membrane
SITYG_RS05405	COG1846	Transcriptional regulator
SITYG_RS05420	COG4109	DRTGG domain
SITYG_RS05425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SITYG_RS05430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SITYG_RS05435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SITYG_RS05440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SITYG_RS05445	COG1051	belongs to the nudix hydrolase family
SITYG_RS05450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SITYG_RS05465	COG0658	competence protein
SITYG_RS05465	COG2333	competence protein COMEC
SITYG_RS05475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SITYG_RS05480	COG0557	exoribonuclease II activity
SITYG_RS05595	COG0542	response to heat
SITYG_RS05600	COG0551	DNA topoisomerase type I activity
SITYG_RS05600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SITYG_RS05715	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SITYG_RS05720	COG2814	Major facilitator Superfamily
SITYG_RS05725	COG0237	dephospho-CoA kinase activity
SITYG_RS05730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SITYG_RS05755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SITYG_RS05765	COG1132	(ABC) transporter
SITYG_RS05770	COG1132	(ABC) transporter
SITYG_RS05785	COG0686	Belongs to the AlaDH PNT family
SITYG_RS05805	COG1702	phosphate starvation-inducible protein PhoH
SITYG_RS05810	COG4479	Belongs to the UPF0346 family
SITYG_RS05815	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SITYG_RS05825	COG0284	orotidine-5'-phosphate decarboxylase activity
SITYG_RS05830	COG0167	dihydroorotate dehydrogenase activity
SITYG_RS05835	COG0543	2 iron, 2 sulfur cluster binding
SITYG_RS05845	COG2814	Major facilitator Superfamily
SITYG_RS05875	COG0726	polysaccharide deacetylase
SITYG_RS05885	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SITYG_RS05900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SITYG_RS05905	COG1609	Transcriptional regulator
SITYG_RS05910	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SITYG_RS05910	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SITYG_RS05920	COG2860	membrane
SITYG_RS05930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SITYG_RS05935	COG0626	cystathionine gamma-synthase activity
SITYG_RS05940	COG0251	oxidation-reduction process
SITYG_RS05950	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SITYG_RS05955	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SITYG_RS05960	COG1956	GAF domain-containing protein
SITYG_RS05980	COG0803	Belongs to the bacterial solute-binding protein 9 family
SITYG_RS05980	COG3443	Belongs to the bacterial solute-binding protein 9 family
SITYG_RS05985	COG0336	Belongs to the RNA methyltransferase TrmD family
SITYG_RS05990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SITYG_RS06005	COG0222	ribosome binding
SITYG_RS06010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SITYG_RS06015	COG2207	Transcriptional regulator
SITYG_RS06015	COG3708	Transcriptional regulator
SITYG_RS06030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SITYG_RS06035	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SITYG_RS06050	COG1177	transmembrane transport
SITYG_RS06055	COG1176	ABC-type spermidine putrescine transport system, permease component I
SITYG_RS06060	COG3842	ATPase activity
SITYG_RS06065	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SITYG_RS06070	COG0481	GTPase activity
SITYG_RS06075	COG0561	phosphatase activity
SITYG_RS06085	COG2195	Cleaves the N-terminal amino acid of tripeptides
SITYG_RS06090	COG0572	uridine kinase
SITYG_RS06095	COG0673	inositol 2-dehydrogenase activity
SITYG_RS06105	COG0726	polysaccharide deacetylase
SITYG_RS06120	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SITYG_RS06130	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SITYG_RS06155	COG0560	Phosphoserine phosphatase
SITYG_RS06160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SITYG_RS06170	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SITYG_RS06175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SITYG_RS06180	COG3442	glutamine amidotransferase
SITYG_RS06190	COG0488	(ABC) transporter
SITYG_RS06215	COG0826	peptidase U32
SITYG_RS06240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SITYG_RS06245	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SITYG_RS06250	COG1051	belongs to the nudix hydrolase family
SITYG_RS06260	COG3091	SprT-like family
SITYG_RS06265	COG2183	response to ionizing radiation
SITYG_RS06275	COG0701	Predicted permease
SITYG_RS06280	COG3689	TIGRFAM TIGR03943 family protein
SITYG_RS06285	COG0477	Major facilitator Superfamily
SITYG_RS06290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SITYG_RS06340	COG0281	malic enzyme
SITYG_RS06350	COG0583	DNA-binding transcription factor activity
SITYG_RS06365	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SITYG_RS06380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SITYG_RS06385	COG4684	Psort location CytoplasmicMembrane, score
SITYG_RS06390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SITYG_RS06400	COG1194	a g-specific adenine glycosylase
SITYG_RS06405	COG0280	phosphate acetyltransferase
SITYG_RS06410	COG0564	pseudouridine synthase activity
SITYG_RS06420	COG2357	RelA SpoT domain protein
SITYG_RS06430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SITYG_RS06435	COG1104	cysteine desulfurase activity
SITYG_RS06455	COG2003	Belongs to the UPF0758 family
SITYG_RS06460	COG0704	Plays a role in the regulation of phosphate uptake
SITYG_RS06465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SITYG_RS06470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SITYG_RS06475	COG0581	inorganic phosphate transmembrane transporter activity
SITYG_RS06480	COG0573	inorganic phosphate transmembrane transporter activity
SITYG_RS06490	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SITYG_RS06490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SITYG_RS06495	COG0483	inositol monophosphate 1-phosphatase activity
SITYG_RS06500	COG4476	Belongs to the UPF0223 family
SITYG_RS06505	COG1393	Belongs to the ArsC family
SITYG_RS06510	COG0196	riboflavin kinase activity
SITYG_RS06515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SITYG_RS06545	COG1132	(ABC) transporter
SITYG_RS06550	COG1132	(ABC) transporter
SITYG_RS06550	COG2375	cellular response to nickel ion
SITYG_RS06560	COG0494	nUDIX hydrolase
SITYG_RS06565	COG0210	DNA helicase
SITYG_RS06570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SITYG_RS06585	COG0469	pyruvate kinase activity
SITYG_RS06590	COG0205	6-phosphofructokinase activity
SITYG_RS06605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SITYG_RS06605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SITYG_RS06620	COG0300	oxidoreductase activity
SITYG_RS06640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SITYG_RS06645	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SITYG_RS06655	COG0577	efflux transmembrane transporter activity
SITYG_RS06660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SITYG_RS06665	COG1268	BioY protein
SITYG_RS06670	COG0072	phenylalanine-tRNA ligase activity
SITYG_RS06670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SITYG_RS06685	COG0488	(ABC) transporter
SITYG_RS06690	COG0617	tRNA 3'-terminal CCA addition
SITYG_RS06695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SITYG_RS06700	COG1307	EDD domain protein, DegV family
SITYG_RS06710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SITYG_RS06710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SITYG_RS06710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SITYG_RS06715	COG1105	Belongs to the carbohydrate kinase PfkB family
SITYG_RS06720	COG1349	DNA-binding transcription factor activity
SITYG_RS06730	COG0492	ferredoxin-NADP+ reductase activity
SITYG_RS06735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SITYG_RS06750	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SITYG_RS06760	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SITYG_RS06765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SITYG_RS06770	COG1346	cytolysis
SITYG_RS06795	COG1132	(ABC) transporter
SITYG_RS06815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SITYG_RS06835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SITYG_RS06840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SITYG_RS06845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SITYG_RS06850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SITYG_RS06855	COG0356	it plays a direct role in the translocation of protons across the membrane
SITYG_RS06865	COG0058	SHG alpha-glucan phosphorylase activity
SITYG_RS06870	COG0297	glycogen (starch) synthase activity
SITYG_RS06885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SITYG_RS06890	COG1074	ATP-dependent DNA helicase activity
SITYG_RS06895	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SITYG_RS06900	COG1668	transmembrane transport
SITYG_RS06905	COG4152	abc transporter atp-binding protein
SITYG_RS06965	COG4443	Transcriptional Coactivator p15 (PC4)
SITYG_RS06975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SITYG_RS06990	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SITYG_RS06995	COG3527	Alpha-acetolactate decarboxylase
SITYG_RS07000	COG0028	Belongs to the TPP enzyme family
SITYG_RS07010	COG0628	permease
SITYG_RS07020	COG0716	FMN binding
SITYG_RS07025	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SITYG_RS07030	COG0254	rRNA binding
SITYG_RS07035	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SITYG_RS07040	COG2827	Endonuclease containing a URI domain
SITYG_RS07045	COG1755	Isoprenylcysteine carboxyl methyltransferase
SITYG_RS07050	COG2723	6-phospho-beta-galactosidase activity
SITYG_RS07055	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SITYG_RS07055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SITYG_RS07060	COG1447	Phosphotransferase system cellobiose-specific component IIA
SITYG_RS07065	COG3711	transcriptional antiterminator
SITYG_RS07070	COG3064	Membrane
SITYG_RS07070	COG3583	domain protein
SITYG_RS07070	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SITYG_RS07075	COG1105	Belongs to the carbohydrate kinase PfkB family
SITYG_RS07080	COG3775	system Galactitol-specific IIC component
SITYG_RS07100	COG0698	ribose 5-phosphate isomerase
SITYG_RS07115	COG0513	Belongs to the DEAD box helicase family
SITYG_RS07130	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SITYG_RS07140	COG3620	sequence-specific DNA binding
SITYG_RS07220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SITYG_RS07225	COG1181	Belongs to the D-alanine--D-alanine ligase family
SITYG_RS07230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SITYG_RS07235	COG0768	penicillin binding
SITYG_RS07240	COG0588	phosphoglycerate mutase activity
SITYG_RS07245	COG0735	belongs to the Fur family
SITYG_RS07255	COG1307	EDD domain protein, DegV family
SITYG_RS07260	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SITYG_RS07265	COG4605	iron ion homeostasis
SITYG_RS07270	COG4604	ABC transporter, ATP-binding protein
SITYG_RS07280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SITYG_RS07285	COG0497	DNA recombination
SITYG_RS07290	COG1438	arginine binding
SITYG_RS07295	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SITYG_RS07300	COG0142	geranyltranstransferase activity
SITYG_RS07305	COG1722	exodeoxyribonuclease VII activity
SITYG_RS07310	COG1570	exodeoxyribonuclease VII activity
SITYG_RS07325	COG1621	beta-fructofuranosidase activity
SITYG_RS07330	COG0395	ABC-type sugar transport system, permease component
SITYG_RS07335	COG1175	transmembrane transport
SITYG_RS07350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SITYG_RS07355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SITYG_RS07360	COG0577	efflux transmembrane transporter activity
SITYG_RS07365	COG1136	(ABC) transporter
SITYG_RS07400	COG4703	Protein of unknown function (DUF1797)
SITYG_RS07405	COG0542	response to heat
SITYG_RS07415	COG2378	regulation of single-species biofilm formation
SITYG_RS07420	COG0494	nUDIX hydrolase
SITYG_RS07430	COG0025	NhaP-type Na H and K H
SITYG_RS07440	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SITYG_RS07445	COG1242	4 iron, 4 sulfur cluster binding
SITYG_RS07455	COG0671	phosphoesterase, PA-phosphatase related
SITYG_RS07460	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SITYG_RS07470	COG0569	domain protein
SITYG_RS07475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SITYG_RS07485	COG1187	pseudouridine synthase activity
SITYG_RS07495	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SITYG_RS07500	COG4974	Belongs to the 'phage' integrase family
SITYG_RS07505	COG0517	IMP dehydrogenase activity
SITYG_RS07515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SITYG_RS07520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SITYG_RS07545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SITYG_RS07550	COG1254	Belongs to the acylphosphatase family
SITYG_RS07570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SITYG_RS07585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SITYG_RS07595	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SITYG_RS07600	COG1160	GTP binding
SITYG_RS07630	COG1484	DNA-dependent DNA replication
SITYG_RS07640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SITYG_RS07655	COG1263	PTS System
SITYG_RS07655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SITYG_RS07655	COG2190	(PTS) system
SITYG_RS07660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SITYG_RS07660	COG2190	(PTS) system
SITYG_RS07660	COG1263	PTS System
SITYG_RS07665	COG0745	RESPONSE REGULATOR receiver
SITYG_RS07670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SITYG_RS07685	COG0501	Belongs to the peptidase M48B family
SITYG_RS07690	COG1704	LemA family
SITYG_RS07695	COG0357	Ribosomal RNA small subunit methyltransferase G
SITYG_RS07705	COG4221	oxidoreductase activity
SITYG_RS07715	COG1122	ATPase activity
SITYG_RS07750	COG4720	Psort location CytoplasmicMembrane, score
SITYG_RS07840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SITYG_RS07845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SITYG_RS07850	COG1464	Belongs to the NlpA lipoprotein family
SITYG_RS07855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SITYG_RS07870	COG1323	Belongs to the UPF0348 family
SITYG_RS07875	COG2226	methyltransferase
SITYG_RS07880	COG0799	negative regulation of ribosome biogenesis
SITYG_RS07885	COG1335	isochorismatase
SITYG_RS07890	COG1713	HD superfamily hydrolase involved in NAD metabolism
SITYG_RS07895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SITYG_RS07900	COG1534	Rna-binding protein
SITYG_RS07905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SITYG_RS07910	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SITYG_RS07925	COG1063	alcohol dehydrogenase
SITYG_RS07930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SITYG_RS07935	COG0154	amidase activity
SITYG_RS07940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SITYG_RS07945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SITYG_RS07950	COG1335	isochorismatase
SITYG_RS07955	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SITYG_RS07960	COG0436	Aminotransferase
SITYG_RS07965	COG0589	response to stress
SITYG_RS07970	COG0561	phosphatase activity
SITYG_RS07975	COG0252	asparaginase activity
SITYG_RS07980	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SITYG_RS07985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SITYG_RS07990	COG0736	holo-[acyl-carrier-protein] synthase activity
SITYG_RS07995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SITYG_RS08005	COG0531	amino acid
SITYG_RS08010	COG1482	cell wall glycoprotein biosynthetic process
SITYG_RS08015	COG2188	Transcriptional regulator
SITYG_RS08020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SITYG_RS08025	COG2723	6-phospho-beta-galactosidase activity
SITYG_RS08035	COG1132	(ABC) transporter
SITYG_RS08050	COG1902	pentaerythritol trinitrate reductase activity
SITYG_RS08055	COG0242	peptide deformylase activity
SITYG_RS08060	COG1940	carbohydrate kinase activity
SITYG_RS08065	COG1263	PTS System
SITYG_RS08065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SITYG_RS08065	COG2190	(PTS) system
SITYG_RS08070	COG1621	beta-fructofuranosidase activity
SITYG_RS08075	COG1609	Transcriptional regulator
SITYG_RS08080	COG0561	phosphatase activity
SITYG_RS08085	COG4608	Belongs to the ABC transporter superfamily
SITYG_RS08090	COG0444	Belongs to the ABC transporter superfamily
SITYG_RS08095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SITYG_RS08100	COG0601	transmembrane transport
SITYG_RS08105	COG4166	transmembrane transport
SITYG_RS08110	COG4166	transmembrane transport
SITYG_RS08120	COG0504	CTP synthase activity
SITYG_RS08125	COG3343	RNA polymerase activity
SITYG_RS08130	COG0544	peptidyl-prolyl cis-trans isomerase activity
SITYG_RS08135	COG4475	Protein of unknown function (DUF436)
SITYG_RS08140	COG4720	Psort location CytoplasmicMembrane, score
SITYG_RS08145	COG0351	phosphomethylpyrimidine kinase
SITYG_RS08150	COG0101	tRNA pseudouridine synthase activity
SITYG_RS08160	COG0484	heat shock protein binding
SITYG_RS08165	COG0443	Heat shock 70 kDa protein
SITYG_RS08170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SITYG_RS08175	COG1420	regulation of RNA biosynthetic process
SITYG_RS08215	COG2848	UPF0210 protein
SITYG_RS08220	COG3830	Belongs to the UPF0237 family
SITYG_RS08225	COG1609	Transcriptional regulator
SITYG_RS08240	COG3716	PTS system mannose fructose sorbose family IID component
SITYG_RS08245	COG3715	PTS system
SITYG_RS08250	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SITYG_RS08255	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
SITYG_RS08265	COG1028	Short-chain dehydrogenase reductase Sdr
SITYG_RS08290	COG5492	domain, Protein
SITYG_RS08295	COG0386	Belongs to the glutathione peroxidase family
SITYG_RS08335	COG1131	(ABC) transporter
SITYG_RS08370	COG2217	Heavy metal translocating P-type atpase
SITYG_RS08390	COG0842	Transport permease protein
SITYG_RS08395	COG1131	(ABC) transporter
SITYG_RS08405	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SITYG_RS08415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SITYG_RS08435	COG3328	transposase activity
SITYG_RS08485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SITYG_RS08490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SITYG_RS08505	COG3842	ATPase activity
SITYG_RS08515	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SITYG_RS08520	COG0215	cysteine-tRNA ligase activity
SITYG_RS08535	COG1045	serine acetyltransferase
SITYG_RS08540	COG1185	polyribonucleotide nucleotidyltransferase activity
SITYG_RS08545	COG1164	Oligoendopeptidase f
SITYG_RS08560	COG1187	pseudouridine synthase activity
SITYG_RS08625	COG2309	aminopeptidase activity
SITYG_RS08630	COG2176	DNA-directed DNA polymerase activity
SITYG_RS08635	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SITYG_RS08640	COG1523	belongs to the glycosyl hydrolase 13 family
SITYG_RS08650	COG3590	peptidase
SITYG_RS08685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SITYG_RS08700	COG1051	belongs to the nudix hydrolase family
SITYG_RS08710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SITYG_RS08730	COG0459	protein refolding
SITYG_RS08745	COG3716	PTS system mannose fructose sorbose family IID component
SITYG_RS08750	COG3715	PTS system
SITYG_RS08770	COG2197	response regulator
SITYG_RS08775	COG4585	Histidine kinase
SITYG_RS08790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SITYG_RS08795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SITYG_RS08805	COG1363	Peptidase, m42
SITYG_RS08885	COG0285	dihydrofolate synthase activity
SITYG_RS08935	COG0442	prolyl-tRNA aminoacylation
SITYG_RS08940	COG0750	zinc metalloprotease
SITYG_RS08945	COG4589	Belongs to the CDS family
SITYG_RS08950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SITYG_RS08965	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SITYG_RS08995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SITYG_RS09005	COG3037	sugar-specific permease SgaT UlaA
SITYG_RS09080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SITYG_RS09110	COG4537	Required for transformation and DNA binding
SITYG_RS09115	COG1459	type II secretion system
SITYG_RS09120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SITYG_RS09140	COG0174	glutamine synthetase
SITYG_RS09145	COG0789	Transcriptional regulator
SITYG_RS09155	COG3942	CHAP domain
SITYG_RS09165	COG0126	phosphoglycerate kinase activity
SITYG_RS09170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SITYG_RS09175	COG0085	RNA polymerase activity
SITYG_RS09180	COG4499	WXG100 protein secretion system (Wss), protein YukC
SITYG_RS09180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SITYG_RS09190	COG0500	methyltransferase
SITYG_RS09200	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SITYG_RS09205	COG1473	amidohydrolase
SITYG_RS09210	COG2171	N-acyltransferase activity
SITYG_RS09215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SITYG_RS09230	COG0756	dUTP diphosphatase activity
SITYG_RS09240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SITYG_RS09245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SITYG_RS09360	COG0203	ribosomal protein L17
SITYG_RS09365	COG0202	RNA polymerase activity
SITYG_RS09370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SITYG_RS09375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SITYG_RS09380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SITYG_RS09385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SITYG_RS09390	COG0563	adenylate kinase activity
SITYG_RS09395	COG0201	protein transport
SITYG_RS09400	COG0200	Binds to the 23S rRNA
SITYG_RS09405	COG1841	ribosomal large subunit assembly
SITYG_RS09410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SITYG_RS09420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SITYG_RS09425	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SITYG_RS09430	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SITYG_RS09435	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SITYG_RS09440	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SITYG_RS09445	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SITYG_RS09450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SITYG_RS09455	COG0255	Belongs to the universal ribosomal protein uL29 family
SITYG_RS09460	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SITYG_RS09465	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SITYG_RS09470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SITYG_RS09480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SITYG_RS09485	COG0089	rRNA binding
SITYG_RS09490	COG0088	Forms part of the polypeptide exit tunnel
SITYG_RS09495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SITYG_RS09500	COG0051	transcription antitermination factor activity, RNA binding
SITYG_RS09510	COG0343	queuine tRNA-ribosyltransferase activity
SITYG_RS09525	COG1832	CoA-binding protein
SITYG_RS09530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SITYG_RS09530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SITYG_RS09560	COG5002	protein histidine kinase activity
SITYG_RS09590	COG1216	Glycosyl transferase, family 2
SITYG_RS09595	COG0438	transferase activity, transferring glycosyl groups
SITYG_RS09605	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SITYG_RS09610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SITYG_RS09625	COG3944	biosynthesis protein
SITYG_RS09630	COG4464	protein tyrosine phosphatase activity
SITYG_RS09670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SITYG_RS09690	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SITYG_RS09695	COG4472	Bacterial protein of unknown function (DUF965)
SITYG_RS09705	COG1393	Belongs to the ArsC family
SITYG_RS09710	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SITYG_RS09715	COG1546	Belongs to the CinA family
SITYG_RS09715	COG1058	Belongs to the CinA family
SITYG_RS09725	COG2818	Glycosylase
SITYG_RS09730	COG0632	four-way junction helicase activity
SITYG_RS09735	COG1395	domain, Protein
SITYG_RS09745	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SITYG_RS09760	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SITYG_RS09765	COG1438	arginine binding
SITYG_RS09770	COG0018	arginyl-trna synthetase
SITYG_RS09775	COG1780	Probably involved in ribonucleotide reductase function
SITYG_RS09785	COG0058	SHG alpha-glucan phosphorylase activity
SITYG_RS09790	COG1640	4-alpha-glucanotransferase
SITYG_RS09800	COG2182	Extracellular solute-binding protein
SITYG_RS09805	COG1175	transmembrane transport
SITYG_RS09810	COG3833	ABC-type maltose transport systems, permease component
SITYG_RS09815	COG5521	maltodextrose utilization protein MalA
SITYG_RS09820	COG1609	Transcriptional regulator
SITYG_RS09825	COG1523	belongs to the glycosyl hydrolase 13 family
SITYG_RS09830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SITYG_RS09845	COG0124	histidyl-tRNA synthetase
SITYG_RS09850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SITYG_RS09855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SITYG_RS09875	COG2946	Replication initiation factor
SITYG_RS09885	COG1674	ftsk spoiiie
SITYG_RS09885	COG1196	nuclear chromosome segregation
SITYG_RS09915	COG1396	sequence-specific DNA binding
SITYG_RS09925	COG2217	Heavy metal translocating P-type atpase
SITYG_RS09935	COG1230	cation diffusion facilitator family transporter
SITYG_RS09945	COG2807	transmembrane transport
SITYG_RS09950	COG2094	Belongs to the DNA glycosylase MPG family
SITYG_RS09960	COG0561	phosphatase activity
SITYG_RS09970	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SITYG_RS09975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SITYG_RS09980	COG1696	Membrane protein involved in D-alanine export
SITYG_RS10050	COG0561	phosphatase activity
SITYG_RS10065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SITYG_RS10070	COG1011	Hydrolase
SITYG_RS10080	COG0305	Participates in initiation and elongation during chromosome replication
SITYG_RS10085	COG0359	binds to the 23S rRNA
SITYG_RS10095	COG0445	tRNA wobble uridine modification
SITYG_RS10100	COG0482	sulfurtransferase activity
SITYG_RS10110	COG1760	l-serine dehydratase
SITYG_RS10115	COG1760	l-serine dehydratase
SITYG_RS10125	COG0741	lytic transglycosylase activity
SITYG_RS10130	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SITYG_RS10135	COG1122	ATPase activity
SITYG_RS10140	COG1122	ATPase activity
SITYG_RS10145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SITYG_RS10155	COG0612	Peptidase, M16
SITYG_RS10160	COG0612	Peptidase, M16
SITYG_RS10170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SITYG_RS10175	COG0517	IMP dehydrogenase activity
SITYG_RS10175	COG0516	GMP reductase activity
SITYG_RS10180	COG0180	Tryptophanyl-tRNA synthetase
SITYG_RS10185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SITYG_RS10190	COG0149	triose-phosphate isomerase activity
SITYG_RS10200	COG0488	(ABC) transporter
SITYG_RS10225	COG4191	Histidine kinase
SITYG_RS10240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SITYG_RS10245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SITYG_RS10250	COG1475	DNA binding