locus-tag	class	description
J4854_RS00005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
J4854_RS00010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4854_RS00015	COG1475	DNA binding
J4854_RS00025	COG0592	DNA-directed DNA polymerase activity
J4854_RS00040	COG0012	GTP binding
J4854_RS00050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J4854_RS00055	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
J4854_RS00070	COG0037	tRNA processing
J4854_RS00075	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J4854_RS00080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J4854_RS00205	COG1792	Involved in formation and maintenance of cell shape
J4854_RS00215	COG3942	CHAP domain
J4854_RS00220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J4854_RS00255	COG4509	Sortase family
J4854_RS00270	COG0436	Aminotransferase
J4854_RS00275	COG1381	Involved in DNA repair and RecF pathway recombination
J4854_RS00285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4854_RS00290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J4854_RS00295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J4854_RS00300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J4854_RS00310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J4854_RS00335	COG3942	CHAP domain
J4854_RS00340	COG0151	Belongs to the GarS family
J4854_RS00345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J4854_RS00360	COG0758	DNA mediated transformation
J4854_RS00370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J4854_RS00375	COG2188	Transcriptional regulator
J4854_RS00385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4854_RS00390	COG3715	PTS system
J4854_RS00395	COG3716	PTS system mannose fructose sorbose family IID component
J4854_RS00405	COG2222	sugar isomerase
J4854_RS00435	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J4854_RS00435	COG2755	lipolytic protein G-D-S-L family
J4854_RS00440	COG1454	alcohol dehydrogenase
J4854_RS00440	COG1012	belongs to the aldehyde dehydrogenase family
J4854_RS00465	COG1063	alcohol dehydrogenase
J4854_RS00500	COG0673	inositol 2-dehydrogenase activity
J4854_RS00515	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
J4854_RS00520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4854_RS00525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
J4854_RS00535	COG1737	Transcriptional regulator
J4854_RS00550	COG1269	ATP hydrolysis coupled proton transport
J4854_RS00555	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J4854_RS00565	COG1527	subunit (C
J4854_RS00570	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
J4854_RS00580	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
J4854_RS00585	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
J4854_RS00590	COG1394	ATPase activity, coupled to movement of substances
J4854_RS00595	COG5632	N-Acetylmuramoyl-L-alanine amidase
J4854_RS00595	COG3409	Peptidoglycan-binding domain 1 protein
J4854_RS00600	COG2807	transmembrane transport
J4854_RS00615	COG0640	Transcriptional regulator
J4854_RS00640	COG0789	Transcriptional regulator
J4854_RS00680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J4854_RS00705	COG0577	efflux transmembrane transporter activity
J4854_RS00710	COG1136	(ABC) transporter
J4854_RS00725	COG0505	Belongs to the CarA family
J4854_RS00735	COG2151	metal-sulfur cluster biosynthetic enzyme
J4854_RS00750	COG0534	Mate efflux family protein
J4854_RS00755	COG0131	Imidazoleglycerol-phosphate dehydratase
J4854_RS00755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
J4854_RS00765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4854_RS00765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
J4854_RS00770	COG1832	CoA-binding protein
J4854_RS00800	COG0088	Forms part of the polypeptide exit tunnel
J4854_RS00810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J4854_RS00815	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
J4854_RS00835	COG0255	Belongs to the universal ribosomal protein uL29 family
J4854_RS00840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J4854_RS00845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J4854_RS00850	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J4854_RS00855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
J4854_RS00860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J4854_RS00880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J4854_RS00885	COG1841	ribosomal large subunit assembly
J4854_RS00895	COG0201	protein transport
J4854_RS00905	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J4854_RS00910	COG0257	Belongs to the bacterial ribosomal protein bL36 family
J4854_RS00915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J4854_RS00920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J4854_RS00925	COG0202	RNA polymerase activity
J4854_RS00930	COG0203	ribosomal protein L17
J4854_RS01025	COG1846	Transcriptional regulator
J4854_RS01030	COG1121	(ABC) transporter
J4854_RS01035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4854_RS01040	COG0803	Belongs to the bacterial solute-binding protein 9 family
J4854_RS01040	COG3443	Belongs to the bacterial solute-binding protein 9 family
J4854_RS01050	COG0500	methyltransferase
J4854_RS01060	COG1733	regulation of RNA biosynthetic process
J4854_RS01075	COG3279	Response regulator of the LytR AlgR family
J4854_RS01090	COG4499	WXG100 protein secretion system (Wss), protein YukC
J4854_RS01090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4854_RS01095	COG0085	RNA polymerase activity
J4854_RS01100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J4854_RS01105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
J4854_RS01120	COG1215	transferase activity, transferring glycosyl groups
J4854_RS01125	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
J4854_RS01135	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
J4854_RS01140	COG1459	type II secretion system
J4854_RS01145	COG4537	Required for transformation and DNA binding
J4854_RS01170	COG0827	DNA restriction-modification system
J4854_RS01175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J4854_RS01180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
J4854_RS01185	COG0285	dihydrofolate synthase activity
J4854_RS01190	COG0302	gtp cyclohydrolase
J4854_RS01195	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
J4854_RS01195	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
J4854_RS01200	COG4868	Belongs to the UPF0371 family
J4854_RS01205	COG1363	Peptidase, m42
J4854_RS01215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4854_RS01220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4854_RS01230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J4854_RS01255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
J4854_RS01265	COG0494	nUDIX hydrolase
J4854_RS01280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
J4854_RS01350	COG3590	peptidase
J4854_RS01355	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J4854_RS01360	COG1349	DNA-binding transcription factor activity
J4854_RS01370	COG1447	Phosphotransferase system cellobiose-specific component IIA
J4854_RS01380	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4854_RS01385	COG1882	Formate acetyltransferase
J4854_RS01400	COG1686	Belongs to the peptidase S11 family
J4854_RS01415	COG1122	ATPase activity
J4854_RS01425	COG0310	cobalt ion transport
J4854_RS01430	COG1846	Transcriptional regulator
J4854_RS01445	COG1174	glycine betaine transport
J4854_RS01450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J4854_RS01455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J4854_RS01460	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
J4854_RS01480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4854_RS01485	COG0765	amino acid transport
J4854_RS01490	COG0765	amino acid transport
J4854_RS01495	COG1126	abc transporter atp-binding protein
J4854_RS01540	COG1862	Preprotein translocase
J4854_RS01545	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J4854_RS01550	COG4589	Belongs to the CDS family
J4854_RS01555	COG0750	zinc metalloprotease
J4854_RS01660	COG2176	DNA-directed DNA polymerase activity
J4854_RS01665	COG1396	sequence-specific DNA binding
J4854_RS01670	COG1132	(ABC) transporter
J4854_RS01680	COG0464	growth
J4854_RS01685	COG2309	aminopeptidase activity
J4854_RS01725	COG1187	pseudouridine synthase activity
J4854_RS01745	COG3118	belongs to the thioredoxin family
J4854_RS01755	COG1164	Oligoendopeptidase f
J4854_RS01775	COG1045	serine acetyltransferase
J4854_RS01785	COG0215	cysteine-tRNA ligase activity
J4854_RS01790	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
J4854_RS01800	COG3842	ATPase activity
J4854_RS01805	COG0366	Alpha amylase catalytic
J4854_RS01820	COG3688	RNA-binding protein containing a PIN domain
J4854_RS01830	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J4854_RS01865	COG1132	(ABC) transporter
J4854_RS01890	COG1396	sequence-specific DNA binding
J4854_RS01895	COG0542	response to heat
J4854_RS01905	COG3237	CsbD-like
J4854_RS01915	COG0604	alcohol dehydrogenase
J4854_RS01920	COG1309	transcriptional regulator
J4854_RS01930	COG0366	Alpha amylase catalytic
J4854_RS01935	COG3830	Belongs to the UPF0237 family
J4854_RS01950	COG0588	phosphoglycerate mutase activity
J4854_RS01955	COG1876	peptidase activity
J4854_RS01965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J4854_RS01975	COG0484	heat shock protein binding
J4854_RS01980	COG3583	domain protein
J4854_RS01980	COG3525	Glycosyl hydrolase, family 20, catalytic domain
J4854_RS01980	COG3064	Membrane
J4854_RS01990	COG0351	phosphomethylpyrimidine kinase
J4854_RS01995	COG4720	Psort location CytoplasmicMembrane, score
J4854_RS02000	COG4475	Protein of unknown function (DUF436)
J4854_RS02005	COG0544	peptidyl-prolyl cis-trans isomerase activity
J4854_RS02010	COG3343	RNA polymerase activity
J4854_RS02020	COG0504	CTP synthase activity
J4854_RS02035	COG0191	fructose-bisphosphate aldolase activity
J4854_RS02040	COG0596	Alpha beta hydrolase
J4854_RS02045	COG4555	ABC transporter
J4854_RS02090	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J4854_RS02120	COG1131	(ABC) transporter
J4854_RS02125	COG0842	Transport permease protein
J4854_RS02130	COG4585	Histidine kinase
J4854_RS02135	COG2197	response regulator
J4854_RS02140	COG0028	Belongs to the TPP enzyme family
J4854_RS02145	COG0440	acetolactate synthase activity
J4854_RS02150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
J4854_RS02155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J4854_RS02170	COG1126	abc transporter atp-binding protein
J4854_RS02175	COG0765	amino acid transport
J4854_RS02190	COG4862	establishment of competence for transformation
J4854_RS02195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4854_RS02205	COG0719	Fe-S assembly protein
J4854_RS02210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J4854_RS02220	COG0719	Fe-S assembly protein
J4854_RS02225	COG1686	Belongs to the peptidase S11 family
J4854_RS02230	COG4166	transmembrane transport
J4854_RS02235	COG0601	transmembrane transport
J4854_RS02240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4854_RS02245	COG0444	Belongs to the ABC transporter superfamily
J4854_RS02250	COG4608	Belongs to the ABC transporter superfamily
J4854_RS02280	COG0527	aspartate kinase activity
J4854_RS02285	COG1024	Enoyl-CoA hydratase
J4854_RS02290	COG1846	Transcriptional regulator
J4854_RS02295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4854_RS02305	COG2070	2-Nitropropane dioxygenase
J4854_RS02310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J4854_RS02315	COG1028	Short-chain dehydrogenase reductase Sdr
J4854_RS02320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J4854_RS02335	COG0439	Biotin carboxylase
J4854_RS02340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
J4854_RS02345	COG0825	malonyl-CoA metabolic process
J4854_RS02360	COG3716	PTS system mannose fructose sorbose family IID component
J4854_RS02365	COG3715	PTS system
J4854_RS02375	COG1064	alcohol dehydrogenase
J4854_RS02380	COG0561	phosphatase activity
J4854_RS02385	COG2252	PERMEase
J4854_RS02390	COG0802	atpase or kinase
J4854_RS02400	COG1316	TRANSCRIPTIONal
J4854_RS02410	COG0537	adenosine 5'-monophosphoramidase activity
J4854_RS02415	COG1131	(ABC) transporter
J4854_RS02430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J4854_RS02440	COG0195	Participates in both transcription termination and antitermination
J4854_RS02445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
J4854_RS02465	COG1283	sodium-dependent phosphate transmembrane transporter activity
J4854_RS02475	COG0656	L-ascorbic acid biosynthetic process
J4854_RS02505	COG1113	amino acid transport
J4854_RS02525	COG0768	penicillin binding
J4854_RS02535	COG0513	Belongs to the DEAD box helicase family
J4854_RS02540	COG0765	amino acid transport
J4854_RS02545	COG1126	abc transporter atp-binding protein
J4854_RS02560	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
J4854_RS02570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
J4854_RS02575	COG3579	cysteine-type endopeptidase activity
J4854_RS02580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4854_RS02585	COG3331	DNA recombination
J4854_RS02590	COG4474	Belongs to the UPF0398 family
J4854_RS02595	COG3599	regulation of cell shape
J4854_RS02605	COG0116	Belongs to the methyltransferase superfamily
J4854_RS02615	COG1854	S-ribosylhomocysteine lyase activity
J4854_RS02620	COG1418	mRNA catabolic process
J4854_RS02625	COG0194	GDP metabolic process
J4854_RS02630	COG1758	RNA polymerase activity
J4854_RS02635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J4854_RS02645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
J4854_RS02645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J4854_RS02650	COG0631	protein serine/threonine phosphatase activity
J4854_RS02655	COG0515	serine threonine protein kinase
J4854_RS02655	COG2815	serine threonine protein kinase
J4854_RS02665	COG4585	Histidine kinase
J4854_RS02670	COG2197	response regulator
J4854_RS02680	COG1098	S1 RNA binding domain
J4854_RS02690	COG1739	Uncharacterized protein family UPF0029
J4854_RS02695	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
J4854_RS02700	COG1040	competence protein
J4854_RS02780	COG3557	Belongs to the UPF0374 family
J4854_RS02790	COG3231	kanamycin kinase activity
J4854_RS02795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J4854_RS02825	COG0519	Catalyzes the synthesis of GMP from XMP
J4854_RS02840	COG1242	4 iron, 4 sulfur cluster binding
J4854_RS02845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
J4854_RS02855	COG0025	NhaP-type Na H and K H
J4854_RS02860	COG1119	ATPase activity
J4854_RS02865	COG0628	permease
J4854_RS02870	COG3711	transcriptional antiterminator
J4854_RS02875	COG1253	flavin adenine dinucleotide binding
J4854_RS02885	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
J4854_RS02890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
J4854_RS02895	COG1534	Rna-binding protein
J4854_RS02900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J4854_RS02905	COG1713	HD superfamily hydrolase involved in NAD metabolism
J4854_RS02910	COG1335	isochorismatase
J4854_RS02915	COG0799	negative regulation of ribosome biogenesis
J4854_RS02920	COG2226	methyltransferase
J4854_RS02945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4854_RS02950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J4854_RS02960	COG0742	ribosomal rna small subunit methyltransferase
J4854_RS02965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J4854_RS02970	COG3480	Lon protease (S16) C-terminal proteolytic domain
J4854_RS02985	COG0785	Cytochrome C biogenesis protein
J4854_RS03000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4854_RS03000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4854_RS03005	COG2207	Transcriptional regulator
J4854_RS03005	COG4753	response regulator
J4854_RS03010	COG2972	Histidine kinase
J4854_RS03015	COG4470	Protein conserved in bacteria
J4854_RS03020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J4854_RS03030	COG0133	tryptophan synthase activity
J4854_RS03045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
J4854_RS03055	COG1187	pseudouridine synthase activity
J4854_RS03060	COG1217	gtp-binding protein TYPA
J4854_RS03080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
J4854_RS03090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J4854_RS03095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J4854_RS03100	COG1799	cell septum assembly
J4854_RS03115	COG3599	regulation of cell shape
J4854_RS03120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J4854_RS03125	COG2153	protein acetylation
J4854_RS03135	COG0494	nUDIX hydrolase
J4854_RS03140	COG0542	response to heat
J4854_RS03145	COG4703	Protein of unknown function (DUF1797)
J4854_RS03150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J4854_RS03160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4854_RS03165	COG1570	exodeoxyribonuclease VII activity
J4854_RS03170	COG1722	exodeoxyribonuclease VII activity
J4854_RS03180	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
J4854_RS03185	COG1438	arginine binding
J4854_RS03190	COG0497	DNA recombination
J4854_RS03195	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J4854_RS03200	COG1307	EDD domain protein, DegV family
J4854_RS03205	COG0776	regulation of translation
J4854_RS03210	COG0735	belongs to the Fur family
J4854_RS03215	COG0588	phosphoglycerate mutase activity
J4854_RS03220	COG0420	3'-5' exonuclease activity
J4854_RS03225	COG0419	ATPase involved in DNA repair
J4854_RS03230	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4854_RS03230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4854_RS03235	COG3655	Transcriptional regulator
J4854_RS03250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
J4854_RS03260	COG0745	RESPONSE REGULATOR receiver
J4854_RS03265	COG2205	protein histidine kinase activity
J4854_RS03270	COG1136	(ABC) transporter
J4854_RS03275	COG0577	efflux transmembrane transporter activity
J4854_RS03295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
J4854_RS03305	COG0732	type I restriction modification DNA specificity domain
J4854_RS03350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4854_RS03370	COG1136	(ABC) transporter
J4854_RS03375	COG0577	efflux transmembrane transporter activity
J4854_RS03380	COG4166	transmembrane transport
J4854_RS03385	COG1695	Transcriptional regulator
J4854_RS03405	COG1028	Short-chain dehydrogenase reductase Sdr
J4854_RS03475	COG0791	NLP P60 protein
J4854_RS03475	COG0741	lytic transglycosylase activity
J4854_RS03505	COG2946	Replication initiation factor
J4854_RS03515	COG1674	ftsk spoiiie
J4854_RS03530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J4854_RS03535	COG0494	nUDIX hydrolase
J4854_RS03545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J4854_RS03550	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J4854_RS03555	COG4166	transmembrane transport
J4854_RS03565	COG0708	Exodeoxyribonuclease III
J4854_RS03575	COG2323	membrane
J4854_RS03580	COG0768	penicillin binding
J4854_RS03585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J4854_RS03595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J4854_RS03600	COG1051	belongs to the nudix hydrolase family
J4854_RS03620	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J4854_RS03635	COG0513	Belongs to the DEAD box helicase family
J4854_RS03645	COG2827	Endonuclease containing a URI domain
J4854_RS03650	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
J4854_RS03655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J4854_RS03660	COG0204	Acyl-transferase
J4854_RS03665	COG1596	polysaccharide export
J4854_RS03665	COG1555	photosystem II stabilization
J4854_RS03670	COG0658	competence protein
J4854_RS03670	COG2333	competence protein COMEC
J4854_RS03685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
J4854_RS03690	COG0433	COG0433 Predicted ATPase
J4854_RS03705	COG2235	arginine
J4854_RS03715	COG0549	Belongs to the carbamate kinase family
J4854_RS03720	COG1288	antiporter activity
J4854_RS03725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4854_RS03730	COG1438	arginine binding
J4854_RS03735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
J4854_RS03770	COG4122	O-methyltransferase activity
J4854_RS03775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
J4854_RS03785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J4854_RS03790	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4854_RS03795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
J4854_RS03800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
J4854_RS03805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4854_RS03815	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J4854_RS03825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J4854_RS03830	COG0297	glycogen (starch) synthase activity
J4854_RS03835	COG3064	Membrane
J4854_RS03845	COG0356	it plays a direct role in the translocation of protons across the membrane
J4854_RS03850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J4854_RS03855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J4854_RS03860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J4854_RS03865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J4854_RS03875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J4854_RS03885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J4854_RS03905	COG0488	(ABC) transporter
J4854_RS03925	COG3442	glutamine amidotransferase
J4854_RS03930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J4854_RS03935	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
J4854_RS03945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4854_RS03955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J4854_RS03965	COG0251	oxidation-reduction process
J4854_RS03970	COG1660	Displays ATPase and GTPase activities
J4854_RS03975	COG0391	Required for morphogenesis under gluconeogenic growth conditions
J4854_RS03980	COG1481	regulation of sporulation
J4854_RS03985	COG0492	ferredoxin-NADP+ reductase activity
J4854_RS03990	COG0828	Belongs to the bacterial ribosomal protein bS21 family
J4854_RS04010	COG1970	mechanosensitive ion channel activity
J4854_RS04015	COG0358	DNA primase activity
J4854_RS04020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J4854_RS04025	COG2151	metal-sulfur cluster biosynthetic enzyme
J4854_RS04030	COG1131	(ABC) transporter
J4854_RS04045	COG0582	viral genome integration into host DNA
J4854_RS04055	COG2176	DNA-directed DNA polymerase activity
J4854_RS04105	COG0305	Participates in initiation and elongation during chromosome replication
J4854_RS04150	COG1396	sequence-specific DNA binding
J4854_RS04195	COG0582	viral genome integration into host DNA
J4854_RS04355	COG0469	pyruvate kinase activity
J4854_RS04365	COG0765	amino acid transport
J4854_RS04370	COG1126	abc transporter atp-binding protein
J4854_RS04380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4854_RS04400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
J4854_RS04405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4854_RS04410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J4854_RS04415	COG0196	riboflavin kinase activity
J4854_RS04420	COG1393	Belongs to the ArsC family
J4854_RS04425	COG4476	Belongs to the UPF0223 family
J4854_RS04430	COG0483	inositol monophosphate 1-phosphatase activity
J4854_RS04435	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
J4854_RS04435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
J4854_RS04440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
J4854_RS04445	COG0573	inorganic phosphate transmembrane transporter activity
J4854_RS04450	COG0581	inorganic phosphate transmembrane transporter activity
J4854_RS04455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4854_RS04460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
J4854_RS04465	COG0704	Plays a role in the regulation of phosphate uptake
J4854_RS04480	COG3279	Response regulator of the LytR AlgR family
J4854_RS04485	COG1131	(ABC) transporter
J4854_RS04495	COG1268	BioY protein
J4854_RS04505	COG0745	RESPONSE REGULATOR receiver
J4854_RS04510	COG5002	protein histidine kinase activity
J4854_RS04520	COG0726	polysaccharide deacetylase
J4854_RS04525	COG0513	Belongs to the DEAD box helicase family
J4854_RS04530	COG0673	inositol 2-dehydrogenase activity
J4854_RS04535	COG0463	Glycosyl transferase, family 2
J4854_RS04545	COG1091	dTDP-4-dehydrorhamnose reductase activity
J4854_RS04555	COG1442	glycosyl transferase family 8
J4854_RS04555	COG1216	Glycosyl transferase, family 2
J4854_RS04560	COG1216	Glycosyl transferase, family 2
J4854_RS04565	COG0463	Glycosyl transferase, family 2
J4854_RS04585	COG1442	glycosyl transferase family 8
J4854_RS04585	COG1216	Glycosyl transferase, family 2
J4854_RS04605	COG1215	transferase activity, transferring glycosyl groups
J4854_RS04625	COG1368	sulfuric ester hydrolase activity
J4854_RS04645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
J4854_RS04655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J4854_RS04660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
J4854_RS04665	COG2131	deaminase
J4854_RS04685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J4854_RS04695	COG4109	DRTGG domain
J4854_RS04700	COG0024	Methionine aminopeptidase
J4854_RS04710	COG1846	Transcriptional regulator
J4854_RS04730	COG4708	membrane
J4854_RS04735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J4854_RS04740	COG1597	lipid kinase activity
J4854_RS04745	COG1523	belongs to the glycosyl hydrolase 13 family
J4854_RS04750	COG1368	sulfuric ester hydrolase activity
J4854_RS04755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4854_RS04760	COG0710	3-dehydroquinate dehydratase activity
J4854_RS04765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J4854_RS04775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J4854_RS04780	COG0287	Prephenate dehydrogenase
J4854_RS04785	COG3679	Belongs to the UPF0342 family
J4854_RS04795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J4854_RS04800	COG0077	Prephenate dehydratase
J4854_RS04810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
J4854_RS04870	COG1045	serine acetyltransferase
J4854_RS04935	COG2337	Toxic component of a toxin-antitoxin (TA) module
J4854_RS04995	COG0740	serine-type endopeptidase activity
J4854_RS05065	COG1388	LysM domain
J4854_RS05065	COG3942	CHAP domain
J4854_RS05145	COG1131	(ABC) transporter
J4854_RS05150	COG1132	(ABC) transporter
J4854_RS05205	COG0366	Alpha amylase catalytic
J4854_RS05250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
J4854_RS05280	COG0716	FMN binding
J4854_RS05285	COG1605	Chorismate mutase
J4854_RS05285	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
J4854_RS05290	COG0038	chloride channel
J4854_RS05295	COG0335	large ribosomal subunit rRNA binding
J4854_RS05305	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
J4854_RS05310	COG1518	maintenance of DNA repeat elements
J4854_RS05340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
J4854_RS05345	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
J4854_RS05355	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
J4854_RS05360	COG0038	chloride channel
J4854_RS05370	COG0813	purine-nucleoside phosphorylase activity
J4854_RS05385	COG0583	DNA-binding transcription factor activity
J4854_RS05395	COG0543	2 iron, 2 sulfur cluster binding
J4854_RS05400	COG0167	dihydroorotate dehydrogenase activity
J4854_RS05405	COG0284	orotidine-5'-phosphate decarboxylase activity
J4854_RS05435	COG1051	belongs to the nudix hydrolase family
J4854_RS05440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J4854_RS05445	COG2755	lipolytic protein G-D-S-L family
J4854_RS05475	COG0066	3-isopropylmalate dehydratase activity
J4854_RS05490	COG0187	DNA topoisomerase II activity
J4854_RS05505	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4854_RS05510	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4854_RS05530	COG0539	negative regulation of cytoplasmic translation
J4854_RS05540	COG0039	L-malate dehydrogenase activity
J4854_RS05545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4854_RS05550	COG3764	Sortase (surface protein transpeptidase)
J4854_RS05560	COG2003	Belongs to the UPF0758 family
J4854_RS05580	COG1104	cysteine desulfurase activity
J4854_RS05585	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
J4854_RS05595	COG2357	RelA SpoT domain protein
J4854_RS05605	COG0564	pseudouridine synthase activity
J4854_RS05610	COG0280	phosphate acetyltransferase
J4854_RS05625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4854_RS05630	COG4684	Psort location CytoplasmicMembrane, score
J4854_RS05635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4854_RS05660	COG1114	Component of the transport system for branched-chain amino acids
J4854_RS05665	COG0785	Cytochrome C biogenesis protein
J4854_RS05670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
J4854_RS05675	COG0431	NADPH-dependent FMN reductase
J4854_RS05675	COG1053	succinate dehydrogenase
J4854_RS05675	COG3976	FMN-binding domain protein
J4854_RS05695	COG0038	chloride channel
J4854_RS05700	COG2822	iron ion transport
J4854_RS05705	COG2837	iron assimilation
J4854_RS05710	COG0672	)-iron permease
J4854_RS05715	COG0805	protein transport
J4854_RS05720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4854_RS05740	COG2233	PERMEase
J4854_RS05745	COG0534	Mate efflux family protein
J4854_RS05750	COG0129	dihydroxy-acid dehydratase activity
J4854_RS05755	COG1942	4-Oxalocrotonate Tautomerase
J4854_RS05760	COG1435	thymidine kinase activity
J4854_RS05770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J4854_RS05775	COG2890	protein-(glutamine-N5) methyltransferase activity
J4854_RS05800	COG0741	lytic transglycosylase activity
J4854_RS05825	COG1401	restriction endodeoxyribonuclease activity
J4854_RS05825	COG1401	restriction endodeoxyribonuclease activity
J4854_RS05840	COG2188	Transcriptional regulator
J4854_RS05850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
J4854_RS05865	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4854_RS05875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J4854_RS05900	COG1131	(ABC) transporter
J4854_RS05925	COG0510	thiamine kinase activity
J4854_RS05990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4854_RS05995	COG0758	DNA mediated transformation
J4854_RS06005	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
J4854_RS06015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4854_RS06020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J4854_RS06025	COG1247	-acetyltransferase
J4854_RS06030	COG1132	(ABC) transporter
J4854_RS06055	COG0222	ribosome binding
J4854_RS06060	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J4854_RS06070	COG1388	LysM domain
J4854_RS06070	COG1705	Flagellar rod assembly protein muramidase FlgJ
J4854_RS06075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J4854_RS06085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
J4854_RS06100	COG1940	carbohydrate kinase activity
J4854_RS06110	COG0488	(ABC) transporter
J4854_RS06115	COG0617	tRNA 3'-terminal CCA addition
J4854_RS06120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J4854_RS06125	COG1307	EDD domain protein, DegV family
J4854_RS06145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4854_RS06145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4854_RS06145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4854_RS06150	COG1105	Belongs to the carbohydrate kinase PfkB family
J4854_RS06155	COG1349	DNA-binding transcription factor activity
J4854_RS06180	COG1837	Belongs to the UPF0109 family
J4854_RS06190	COG1011	Hydrolase
J4854_RS06210	COG0561	phosphatase activity
J4854_RS06215	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4854_RS06220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J4854_RS06225	COG0505	Belongs to the CarA family
J4854_RS06230	COG0540	Belongs to the ATCase OTCase family
J4854_RS06235	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J4854_RS06245	COG2824	Alkylphosphonate utilization operon protein PhnA
J4854_RS06265	COG4555	ABC transporter
J4854_RS06270	COG1051	belongs to the nudix hydrolase family
J4854_RS06300	COG1131	(ABC) transporter
J4854_RS06315	COG0765	amino acid transport
J4854_RS06320	COG1126	abc transporter atp-binding protein
J4854_RS06335	COG1132	(ABC) transporter
J4854_RS06340	COG1132	(ABC) transporter
J4854_RS06355	COG0017	Asparaginyl-tRNA synthetase
J4854_RS06360	COG0436	Aminotransferase
J4854_RS06370	COG1846	Transcriptional regulator
J4854_RS06375	COG3022	response to hydroperoxide
J4854_RS06385	COG1272	protein, Hemolysin III
J4854_RS06390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4854_RS06400	COG1132	(ABC) transporter
J4854_RS06405	COG1132	(ABC) transporter
J4854_RS06410	COG2315	Protein conserved in bacteria
J4854_RS06420	COG1079	Belongs to the binding-protein-dependent transport system permease family
J4854_RS06425	COG4603	Belongs to the binding-protein-dependent transport system permease family
J4854_RS06430	COG3845	ABC transporter
J4854_RS06435	COG1744	ABC transporter substrate-binding protein PnrA-like
J4854_RS06445	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J4854_RS06455	COG2813	Specifically methylates the guanine in position
J4854_RS06500	COG1573	uracil-dna glycosylase
J4854_RS06565	COG0647	UMP catabolic process
J4854_RS06580	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4854_RS06590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J4854_RS06595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J4854_RS06605	COG0564	pseudouridine synthase activity
J4854_RS06610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J4854_RS06615	COG0583	DNA-binding transcription factor activity
J4854_RS06620	COG3775	system Galactitol-specific IIC component
J4854_RS06635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J4854_RS06665	COG1104	cysteine desulfurase activity
J4854_RS06710	COG1177	transmembrane transport
J4854_RS06715	COG1177	transmembrane transport
J4854_RS06720	COG3842	ATPase activity
J4854_RS06740	COG0460	homoserine dehydrogenase
J4854_RS06750	COG1418	mRNA catabolic process
J4854_RS06770	COG1131	(ABC) transporter
J4854_RS06775	COG4187	Peptidase family M20/M25/M40
J4854_RS06785	COG3118	belongs to the thioredoxin family
J4854_RS06810	COG0137	argininosuccinate synthase activity
J4854_RS06815	COG4166	transmembrane transport
J4854_RS06820	COG1363	Peptidase, m42
J4854_RS06865	COG0745	RESPONSE REGULATOR receiver
J4854_RS06870	COG2205	protein histidine kinase activity
J4854_RS06900	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
J4854_RS06910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J4854_RS06925	COG1472	Belongs to the glycosyl hydrolase 3 family
J4854_RS06930	COG1609	Transcriptional regulator
J4854_RS06935	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
J4854_RS06935	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
J4854_RS06950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J4854_RS06960	COG0572	uridine kinase
J4854_RS06985	COG1088	dTDP-glucose 4,6-dehydratase activity
J4854_RS06995	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
J4854_RS07010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
J4854_RS07015	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
J4854_RS07020	COG2384	SAM-dependent methyltransferase
J4854_RS07025	COG0625	glutathione transferase activity
J4854_RS07030	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
J4854_RS07045	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
J4854_RS07050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J4854_RS07075	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
J4854_RS07075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
J4854_RS07115	COG2226	methyltransferase
J4854_RS07120	COG0300	oxidoreductase activity
J4854_RS07135	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J4854_RS07155	COG1074	ATP-dependent DNA helicase activity
J4854_RS07160	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
J4854_RS07165	COG0386	Belongs to the glutathione peroxidase family
J4854_RS07170	COG1132	(ABC) transporter
J4854_RS07175	COG1132	(ABC) transporter
J4854_RS07195	COG4989	oxidoreductase activity
J4854_RS07230	COG1668	transmembrane transport
J4854_RS07235	COG4152	abc transporter atp-binding protein
J4854_RS07245	COG1476	TRANSCRIPTIONal
J4854_RS07255	COG0072	phenylalanine-tRNA ligase activity
J4854_RS07255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4854_RS07280	COG1293	RNA-binding protein homologous to eukaryotic snRNP
J4854_RS07285	COG3527	Alpha-acetolactate decarboxylase
J4854_RS07290	COG0457	Tetratricopeptide repeat
J4854_RS07295	COG0628	permease
J4854_RS07300	COG2706	6-phosphogluconolactonase activity
J4854_RS07315	COG1959	2 iron, 2 sulfur cluster binding
J4854_RS07325	COG0698	ribose 5-phosphate isomerase
J4854_RS07330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4854_RS07335	COG0148	phosphopyruvate hydratase activity
J4854_RS07350	COG0560	Phosphoserine phosphatase
J4854_RS07355	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
J4854_RS07360	COG0187	DNA topoisomerase II activity
J4854_RS07365	COG0546	phosphoglycolate phosphatase activity
J4854_RS07370	COG0693	protein deglycase activity
J4854_RS07375	COG0772	Belongs to the SEDS family
J4854_RS07380	COG2855	membrane
J4854_RS07385	COG1199	ATP-dependent helicase activity
J4854_RS07385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
J4854_RS07395	COG2177	Part of the ABC transporter FtsEX involved in
J4854_RS07400	COG2884	Cell division ATP-binding protein ftsE
J4854_RS07415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J4854_RS07430	COG1078	dGTPase activity
J4854_RS07445	COG0149	triose-phosphate isomerase activity
J4854_RS07450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
J4854_RS07455	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J4854_RS07460	COG0772	Belongs to the SEDS family
J4854_RS07470	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J4854_RS07485	COG0577	efflux transmembrane transporter activity
J4854_RS07490	COG1136	(ABC) transporter
J4854_RS07500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4854_RS07505	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
J4854_RS07510	COG4443	Transcriptional Coactivator p15 (PC4)
J4854_RS07520	COG0826	peptidase U32
J4854_RS07550	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
J4854_RS07565	COG3091	SprT-like family
J4854_RS07570	COG2183	response to ionizing radiation
J4854_RS07580	COG0701	Predicted permease
J4854_RS07585	COG3689	TIGRFAM TIGR03943 family protein
J4854_RS07590	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
J4854_RS07595	COG0552	protein localization to endoplasmic reticulum
J4854_RS07600	COG0561	phosphatase activity
J4854_RS07605	COG0561	phosphatase activity
J4854_RS07610	COG1196	nuclear chromosome segregation
J4854_RS07615	COG0571	ribonuclease III activity
J4854_RS07620	COG2832	Protein of unknown function (DUF454)
J4854_RS07640	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J4854_RS07645	COG5002	protein histidine kinase activity
J4854_RS07650	COG0745	RESPONSE REGULATOR receiver
J4854_RS07670	COG0438	transferase activity, transferring glycosyl groups
J4854_RS07680	COG1609	Transcriptional regulator
J4854_RS07685	COG0006	proline dipeptidase activity
J4854_RS07695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4854_RS07700	COG0765	amino acid transport
J4854_RS07705	COG0765	amino acid transport
J4854_RS07710	COG1959	2 iron, 2 sulfur cluster binding
J4854_RS07720	COG1914	H( )-stimulated, divalent metal cation uptake system
J4854_RS07730	COG3615	Tellurite resistance protein tehB
J4854_RS07730	COG0500	methyltransferase
J4854_RS07735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J4854_RS07740	COG0557	exoribonuclease II activity
J4854_RS07750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J4854_RS07755	COG2814	Major facilitator Superfamily
J4854_RS07760	COG0237	dephospho-CoA kinase activity
J4854_RS07765	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
J4854_RS07775	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J4854_RS07785	COG1132	(ABC) transporter
J4854_RS07790	COG1132	(ABC) transporter
J4854_RS07805	COG1702	phosphate starvation-inducible protein PhoH
J4854_RS07825	COG0528	UMP kinase activity
J4854_RS07830	COG0081	regulation of translation
J4854_RS07835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J4854_RS07845	COG2274	protein secretion by the type I secretion system
J4854_RS07845	COG3271	cysteine-type peptidase activity
J4854_RS07855	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J4854_RS07860	COG0346	lactoylglutathione lyase activity
J4854_RS07865	COG0697	spore germination
J4854_RS07865	COG1674	ftsk spoiiie
J4854_RS07900	COG0488	(ABC) transporter
J4854_RS07905	COG1393	Belongs to the ArsC family
J4854_RS07910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
J4854_RS07925	COG4467	Involved in initiation control of chromosome replication
J4854_RS07930	COG0470	DNA polymerase III
J4854_RS07935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
J4854_RS07940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4854_RS07945	COG0517	IMP dehydrogenase activity
J4854_RS07955	COG1396	sequence-specific DNA binding
J4854_RS07995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
J4854_RS08000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J4854_RS08005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
J4854_RS08010	COG0626	cystathionine gamma-synthase activity
J4854_RS08015	COG2244	polysaccharide biosynthetic process
J4854_RS08020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
J4854_RS08040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J4854_RS08045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4854_RS08050	COG4120	Belongs to the binding-protein-dependent transport system permease family
J4854_RS08060	COG0671	phosphoesterase, PA-phosphatase related
J4854_RS08065	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
J4854_RS08075	COG0569	domain protein
J4854_RS08080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4854_RS08085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J4854_RS08090	COG1187	pseudouridine synthase activity
J4854_RS08095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J4854_RS08100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
J4854_RS08105	COG4974	Belongs to the 'phage' integrase family
J4854_RS08125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J4854_RS08150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
J4854_RS08155	COG1254	Belongs to the acylphosphatase family
J4854_RS08165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4854_RS08170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J4854_RS08190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
J4854_RS08210	COG0778	Nitroreductase
J4854_RS08215	COG1484	DNA-dependent DNA replication
J4854_RS08225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J4854_RS08235	COG2190	(PTS) system
J4854_RS08235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4854_RS08235	COG1263	PTS System
J4854_RS08240	COG0745	RESPONSE REGULATOR receiver
J4854_RS08245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
J4854_RS08250	COG2268	Band 7 protein
J4854_RS08280	COG0501	Belongs to the peptidase M48B family
J4854_RS08285	COG1704	LemA family
J4854_RS08290	COG0357	Ribosomal RNA small subunit methyltransferase G
J4854_RS08295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4854_RS08300	COG4221	oxidoreductase activity
J4854_RS08310	COG1122	ATPase activity
J4854_RS08360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4854_RS08375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4854_RS08380	COG1473	amidohydrolase
J4854_RS08395	COG3250	beta-galactosidase activity
J4854_RS08400	COG1063	alcohol dehydrogenase
J4854_RS08435	COG1216	Glycosyl transferase, family 2
J4854_RS08435	COG1442	glycosyl transferase family 8
J4854_RS08440	COG1442	glycosyl transferase family 8
J4854_RS08445	COG1335	isochorismatase
J4854_RS08450	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
J4854_RS08455	COG0436	Aminotransferase
J4854_RS08460	COG0589	response to stress
J4854_RS08465	COG0561	phosphatase activity
J4854_RS08470	COG0252	asparaginase activity
J4854_RS08475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J4854_RS08480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J4854_RS08485	COG0736	holo-[acyl-carrier-protein] synthase activity
J4854_RS08490	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J4854_RS08495	COG0653	protein targeting
J4854_RS08500	COG0531	amino acid
J4854_RS08505	COG0789	Transcriptional regulator
J4854_RS08510	COG1482	cell wall glycoprotein biosynthetic process
J4854_RS08515	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J4854_RS08530	COG1132	(ABC) transporter
J4854_RS08545	COG0242	peptide deformylase activity
J4854_RS08550	COG1940	carbohydrate kinase activity
J4854_RS08555	COG2190	(PTS) system
J4854_RS08555	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4854_RS08555	COG1263	PTS System
J4854_RS08560	COG1621	beta-fructofuranosidase activity
J4854_RS08565	COG1609	Transcriptional regulator
J4854_RS08570	COG1304	FMN binding
J4854_RS08600	COG0006	proline dipeptidase activity
J4854_RS08605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J4854_RS08620	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J4854_RS08625	COG0629	single-stranded DNA binding
J4854_RS08650	COG0737	Belongs to the 5'-nucleotidase family
J4854_RS08660	COG1268	BioY protein
J4854_RS08665	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
J4854_RS08685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4854_RS08710	COG3711	transcriptional antiterminator
J4854_RS08715	COG3684	Belongs to the aldolase LacD family
J4854_RS08720	COG1105	Belongs to the carbohydrate kinase PfkB family
J4854_RS08725	COG0698	ribose 5-phosphate isomerase
J4854_RS08735	COG1349	DNA-binding transcription factor activity
J4854_RS08740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4854_RS08745	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J4854_RS08765	COG0569	domain protein
J4854_RS08770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
J4854_RS08780	COG0110	maltose O-acetyltransferase activity
J4854_RS08805	COG0561	phosphatase activity
J4854_RS08810	COG0588	phosphoglycerate mutase activity
J4854_RS08815	COG3711	transcriptional antiterminator
J4854_RS08820	COG1263	PTS System
J4854_RS08820	COG2190	(PTS) system
J4854_RS08820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4854_RS08825	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
J4854_RS08830	COG2814	Major facilitator Superfamily
J4854_RS08835	COG0656	L-ascorbic acid biosynthetic process
J4854_RS08845	COG2211	Major facilitator Superfamily
J4854_RS08850	COG3842	ATPase activity
J4854_RS08855	COG1396	sequence-specific DNA binding
J4854_RS08860	COG1230	cation diffusion facilitator family transporter
J4854_RS08895	COG1122	ATPase activity
J4854_RS08900	COG1122	ATPase activity
J4854_RS08905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J4854_RS08935	COG2205	protein histidine kinase activity
J4854_RS08940	COG0745	RESPONSE REGULATOR receiver
J4854_RS08950	COG2723	6-phospho-beta-galactosidase activity
J4854_RS08960	COG0028	Belongs to the TPP enzyme family
J4854_RS09010	COG0561	phosphatase activity
J4854_RS09020	COG1811	Na channel or pump
J4854_RS09025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J4854_RS09035	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4854_RS09035	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
J4854_RS09040	COG0167	dihydroorotate dehydrogenase activity
J4854_RS09045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J4854_RS09055	COG0668	transmembrane transport
J4854_RS09060	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
J4854_RS09065	COG1115	amino acid carrier protein
J4854_RS09075	COG1193	negative regulation of DNA recombination
J4854_RS09095	COG0681	Belongs to the peptidase S26 family
J4854_RS09100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
J4854_RS09105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4854_RS09110	COG1882	Formate acetyltransferase
J4854_RS09130	COG3425	synthase
J4854_RS09170	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J4854_RS09205	COG1606	tRNA processing
J4854_RS09210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4854_RS09215	COG3875	lactate racemase activity
J4854_RS09220	COG1691	(AIR) carboxylase
J4854_RS09225	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
J4854_RS09230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
J4854_RS09235	COG2081	HI0933 family
J4854_RS09260	COG0366	Alpha amylase catalytic
J4854_RS09260	COG0366	Alpha amylase catalytic
J4854_RS09285	COG0456	acetyltransferase
J4854_RS09290	COG1214	PFAM Peptidase M22, glycoprotease
J4854_RS09295	COG5503	Protein of unknown function (DUF1447)
J4854_RS09305	COG0174	glutamine synthetase
J4854_RS09310	COG0789	Transcriptional regulator
J4854_RS09320	COG0126	phosphoglycerate kinase activity
J4854_RS09330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J4854_RS09350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J4854_RS09355	COG3481	metal-dependent phosphohydrolase, HD sub domain
J4854_RS09370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J4854_RS09375	COG1162	GTPase activity
J4854_RS09400	COG0084	hydrolase, TatD family'
J4854_RS09405	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J4854_RS09415	COG1847	R3H domain protein
J4854_RS09425	COG0594	ribonuclease P activity
J4854_RS09460	COG0653	protein targeting
J4854_RS09480	COG0201	protein transport
J4854_RS09535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4854_RS09555	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
J4854_RS09560	COG0756	dUTP diphosphatase activity
J4854_RS09570	COG4932	domain protein
J4854_RS09570	COG1388	LysM domain
J4854_RS09580	COG0463	Glycosyl transferase, family 2
J4854_RS09585	COG4932	domain protein
J4854_RS09585	COG1388	LysM domain
J4854_RS09595	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J4854_RS09600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J4854_RS09605	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J4854_RS09615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J4854_RS09655	COG0166	Belongs to the GPI family
J4854_RS09670	COG1132	(ABC) transporter
J4854_RS09685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
J4854_RS09695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4854_RS09715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J4854_RS09740	COG4463	regulation of RNA biosynthetic process
J4854_RS09755	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J4854_RS09785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J4854_RS09790	COG2321	neutral zinc metallopeptidase
J4854_RS09795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4854_RS09800	COG0564	pseudouridine synthase activity
J4854_RS09815	COG0438	transferase activity, transferring glycosyl groups
J4854_RS09825	COG0562	UDP-galactopyranose mutase
J4854_RS09840	COG1216	Glycosyl transferase, family 2
J4854_RS09840	COG1442	glycosyl transferase family 8
J4854_RS09855	COG0297	glycogen (starch) synthase activity
J4854_RS09865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J4854_RS09870	COG0489	protein tyrosine kinase activity
J4854_RS09875	COG3944	biosynthesis protein
J4854_RS09880	COG4464	protein tyrosine phosphatase activity
J4854_RS09885	COG1316	TRANSCRIPTIONal
J4854_RS09890	COG0602	queuosine metabolic process
J4854_RS09905	COG1328	CTP reductase activity
J4854_RS09915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
J4854_RS09925	COG0285	dihydrofolate synthase activity
J4854_RS09930	COG3906	Belongs to the UPF0473 family
J4854_RS09935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J4854_RS09940	COG4472	Bacterial protein of unknown function (DUF965)
J4854_RS09950	COG1393	Belongs to the ArsC family
J4854_RS09960	COG1058	Belongs to the CinA family
J4854_RS09960	COG1546	Belongs to the CinA family
J4854_RS09970	COG0519	Catalyzes the synthesis of GMP from XMP
J4854_RS09980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
J4854_RS09995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
J4854_RS10000	COG1438	arginine binding
J4854_RS10005	COG0018	arginyl-trna synthetase
J4854_RS10010	COG1780	Probably involved in ribonucleotide reductase function
J4854_RS10025	COG0058	SHG alpha-glucan phosphorylase activity
J4854_RS10030	COG1640	4-alpha-glucanotransferase
J4854_RS10035	COG2182	Extracellular solute-binding protein
J4854_RS10040	COG1175	transmembrane transport
J4854_RS10045	COG3833	ABC-type maltose transport systems, permease component
J4854_RS10050	COG5521	maltodextrose utilization protein MalA
J4854_RS10055	COG1609	Transcriptional regulator
J4854_RS10060	COG1523	belongs to the glycosyl hydrolase 13 family
J4854_RS10065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4854_RS10080	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
J4854_RS10090	COG1696	Membrane protein involved in D-alanine export
J4854_RS10130	COG1511	domain protein
J4854_RS10130	COG1511	domain protein
J4854_RS10140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J4854_RS10145	COG1116	anion transmembrane transporter activity
J4854_RS10150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J4854_RS10155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J4854_RS10165	COG0305	Participates in initiation and elongation during chromosome replication
J4854_RS10170	COG0359	binds to the 23S rRNA
J4854_RS10180	COG0445	tRNA wobble uridine modification
J4854_RS10200	COG1760	l-serine dehydratase
J4854_RS10205	COG1760	l-serine dehydratase
J4854_RS10215	COG0741	lytic transglycosylase activity
J4854_RS10220	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J4854_RS10225	COG1122	ATPase activity
J4854_RS10230	COG1122	ATPase activity
J4854_RS10235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J4854_RS10245	COG0612	Peptidase, M16
J4854_RS10250	COG0612	Peptidase, M16
J4854_RS10260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J4854_RS10265	COG0517	IMP dehydrogenase activity
J4854_RS10265	COG0516	GMP reductase activity
J4854_RS10270	COG0180	Tryptophanyl-tRNA synthetase
J4854_RS10275	COG0488	(ABC) transporter
J4854_RS10300	COG3290	protein histidine kinase activity