locus-tag	class	description
I6J15_RS00005	COG0024	Methionine aminopeptidase
I6J15_RS00010	COG4109	DRTGG domain
I6J15_RS00015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6J15_RS00020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J15_RS00035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6J15_RS00050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6J15_RS00055	COG1956	GAF domain-containing protein
I6J15_RS00060	COG0066	3-isopropylmalate dehydratase activity
I6J15_RS00065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6J15_RS00090	COG0513	Belongs to the DEAD box helicase family
I6J15_RS00095	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6J15_RS00125	COG0372	Belongs to the citrate synthase family
I6J15_RS00130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6J15_RS00135	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6J15_RS00140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J15_RS00145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6J15_RS00150	COG3859	Proton-coupled thiamine transporter YuaJ
I6J15_RS00160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J15_RS00160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6J15_RS00170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J15_RS00170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6J15_RS00175	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6J15_RS00180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6J15_RS00185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6J15_RS00190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6J15_RS00205	COG0436	Aminotransferase
I6J15_RS00210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6J15_RS00215	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6J15_RS00225	COG4122	O-methyltransferase activity
I6J15_RS00230	COG0546	phosphoglycolate phosphatase activity
I6J15_RS00250	COG1187	pseudouridine synthase activity
I6J15_RS00255	COG0363	glucosamine-6-phosphate deaminase activity
I6J15_RS00265	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6J15_RS00270	COG0217	transcriptional regulatory protein
I6J15_RS00275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6J15_RS00280	COG1466	dna polymerase III delta subunit
I6J15_RS00290	COG1555	photosystem II stabilization
I6J15_RS00290	COG1596	polysaccharide export
I6J15_RS00295	COG0204	Acyl-transferase
I6J15_RS00300	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6J15_RS00310	COG0513	Belongs to the DEAD box helicase family
I6J15_RS00335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J15_RS00345	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J15_RS00355	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6J15_RS00360	COG0768	penicillin binding
I6J15_RS00370	COG1827	regulation of RNA biosynthetic process
I6J15_RS00375	COG0588	phosphoglycerate mutase activity
I6J15_RS00380	COG2217	Heavy metal translocating P-type atpase
I6J15_RS00385	COG0640	Transcriptional regulator
I6J15_RS00390	COG0167	dihydroorotate dehydrogenase activity
I6J15_RS00395	COG3104	oligopeptide transport
I6J15_RS00410	COG4698	Protein conserved in bacteria
I6J15_RS00415	COG2755	lipolytic protein G-D-S-L family
I6J15_RS00420	COG1307	EDD domain protein, DegV family
I6J15_RS00425	COG0497	DNA recombination
I6J15_RS00430	COG1438	arginine binding
I6J15_RS00435	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6J15_RS00455	COG1376	ErfK ybiS ycfS ynhG family protein
I6J15_RS00465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6J15_RS00480	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6J15_RS00480	COG1918	ferrous iron import across plasma membrane
I6J15_RS00495	COG0765	amino acid transport
I6J15_RS00500	COG4703	Protein of unknown function (DUF1797)
I6J15_RS00505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6J15_RS00525	COG0542	response to heat
I6J15_RS00545	COG3599	regulation of cell shape
I6J15_RS00560	COG1799	cell septum assembly
I6J15_RS00565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6J15_RS00625	COG1217	gtp-binding protein TYPA
I6J15_RS00635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J15_RS00640	COG1940	carbohydrate kinase activity
I6J15_RS00650	COG0783	Belongs to the Dps family
I6J15_RS00660	COG1914	H( )-stimulated, divalent metal cation uptake system
I6J15_RS00675	COG0135	phosphoribosylanthranilate isomerase activity
I6J15_RS00680	COG0134	indole-3-glycerol-phosphate synthase activity
I6J15_RS00720	COG4470	Protein conserved in bacteria
I6J15_RS00725	COG0737	Belongs to the 5'-nucleotidase family
I6J15_RS00735	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6J15_RS00740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6J15_RS00745	COG0742	ribosomal rna small subunit methyltransferase
I6J15_RS00770	COG2801	Transposase and inactivated derivatives
I6J15_RS00780	COG4716	Myosin-crossreactive antigen
I6J15_RS00790	COG0525	valine-tRNA ligase activity
I6J15_RS00815	COG1428	Deoxynucleoside kinase
I6J15_RS00830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6J15_RS00840	COG2137	regulation of response to DNA damage stimulus
I6J15_RS00845	COG3557	Belongs to the UPF0374 family
I6J15_RS00915	COG1040	competence protein
I6J15_RS00920	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6J15_RS00925	COG1739	Uncharacterized protein family UPF0029
I6J15_RS00935	COG1098	S1 RNA binding domain
I6J15_RS00945	COG2197	response regulator
I6J15_RS00950	COG4585	Histidine kinase
I6J15_RS00960	COG2815	serine threonine protein kinase
I6J15_RS00960	COG0515	serine threonine protein kinase
I6J15_RS00970	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J15_RS00970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J15_RS00980	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6J15_RS01000	COG1854	S-ribosylhomocysteine lyase activity
I6J15_RS01015	COG0116	Belongs to the methyltransferase superfamily
I6J15_RS01025	COG3599	regulation of cell shape
I6J15_RS01035	COG3331	DNA recombination
I6J15_RS01040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J15_RS01045	COG3579	cysteine-type endopeptidase activity
I6J15_RS01055	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6J15_RS01060	COG0492	ferredoxin-NADP+ reductase activity
I6J15_RS01070	COG1126	abc transporter atp-binding protein
I6J15_RS01085	COG0513	Belongs to the DEAD box helicase family
I6J15_RS01090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J15_RS01095	COG0768	penicillin binding
I6J15_RS01105	COG0275	rRNA processing
I6J15_RS01115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6J15_RS01125	COG1131	(ABC) transporter
I6J15_RS01170	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6J15_RS01195	COG0561	phosphatase activity
I6J15_RS01200	COG2860	membrane
I6J15_RS01210	COG2217	Heavy metal translocating P-type atpase
I6J15_RS01225	COG1611	Belongs to the LOG family
I6J15_RS01230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6J15_RS01235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6J15_RS01245	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6J15_RS01250	COG0195	Participates in both transcription termination and antitermination
I6J15_RS01270	COG0463	Glycosyl transferase, family 2
I6J15_RS01275	COG3447	MASE1 domain protein
I6J15_RS01275	COG5002	protein histidine kinase activity
I6J15_RS01275	COG5001	Diguanylate cyclase
I6J15_RS01285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6J15_RS01295	COG4473	ABC transporter
I6J15_RS01300	COG1131	(ABC) transporter
I6J15_RS01305	COG0537	adenosine 5'-monophosphoramidase activity
I6J15_RS01315	COG1316	TRANSCRIPTIONal
I6J15_RS01325	COG0802	atpase or kinase
I6J15_RS01330	COG2252	PERMEase
I6J15_RS01345	COG0561	phosphatase activity
I6J15_RS01355	COG3715	PTS system
I6J15_RS01360	COG3716	PTS system mannose fructose sorbose family IID component
I6J15_RS01370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6J15_RS01385	COG0439	Biotin carboxylase
I6J15_RS01400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6J15_RS01405	COG1028	Short-chain dehydrogenase reductase Sdr
I6J15_RS01410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6J15_RS01415	COG2070	2-Nitropropane dioxygenase
I6J15_RS01425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6J15_RS01435	COG1024	Enoyl-CoA hydratase
I6J15_RS01440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J15_RS01445	COG0527	aspartate kinase activity
I6J15_RS01490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J15_RS01495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6J15_RS01510	COG3715	PTS system
I6J15_RS01530	COG4608	Belongs to the ABC transporter superfamily
I6J15_RS01535	COG0444	Belongs to the ABC transporter superfamily
I6J15_RS01540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6J15_RS01545	COG0601	transmembrane transport
I6J15_RS01550	COG4166	transmembrane transport
I6J15_RS01555	COG1686	Belongs to the peptidase S11 family
I6J15_RS01560	COG0719	Fe-S assembly protein
I6J15_RS01570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6J15_RS01575	COG0719	Fe-S assembly protein
I6J15_RS01585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6J15_RS01605	COG0765	amino acid transport
I6J15_RS01610	COG1126	abc transporter atp-binding protein
I6J15_RS01625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6J15_RS01635	COG0440	acetolactate synthase activity
I6J15_RS01640	COG0028	Belongs to the TPP enzyme family
I6J15_RS01645	COG0129	dihydroxy-acid dehydratase activity
I6J15_RS01655	COG1461	Dihydroxyacetone kinase
I6J15_RS01665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6J15_RS01690	COG0504	CTP synthase activity
I6J15_RS01705	COG0668	transmembrane transport
I6J15_RS01735	COG0443	Heat shock 70 kDa protein
I6J15_RS01750	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J15_RS01755	COG1876	peptidase activity
I6J15_RS01770	COG3830	Belongs to the UPF0237 family
I6J15_RS01810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6J15_RS01840	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6J15_RS01850	COG1045	serine acetyltransferase
I6J15_RS01860	COG1185	polyribonucleotide nucleotidyltransferase activity
I6J15_RS01870	COG1454	alcohol dehydrogenase
I6J15_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
I6J15_RS01895	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6J15_RS01900	COG1846	Transcriptional regulator
I6J15_RS01920	COG4589	Belongs to the CDS family
I6J15_RS01925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6J15_RS01930	COG1862	Preprotein translocase
I6J15_RS01940	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6J15_RS01945	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6J15_RS01950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J15_RS01955	COG1609	Transcriptional regulator
I6J15_RS01960	COG0366	Alpha amylase catalytic
I6J15_RS01965	COG0366	Alpha amylase catalytic
I6J15_RS01970	COG0395	ABC-type sugar transport system, permease component
I6J15_RS01975	COG1175	transmembrane transport
I6J15_RS01980	COG1653	transport
I6J15_RS01985	COG3345	alpha-galactosidase
I6J15_RS01990	COG2207	Transcriptional regulator
I6J15_RS02030	COG2723	6-phospho-beta-galactosidase activity
I6J15_RS02035	COG3711	transcriptional antiterminator
I6J15_RS02060	COG0698	ribose 5-phosphate isomerase
I6J15_RS02070	COG3842	ATPase activity
I6J15_RS02095	COG1940	carbohydrate kinase activity
I6J15_RS02100	COG2188	Transcriptional regulator
I6J15_RS02110	COG1482	cell wall glycoprotein biosynthetic process
I6J15_RS02115	COG2188	Transcriptional regulator
I6J15_RS02120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J15_RS02125	COG2723	6-phospho-beta-galactosidase activity
I6J15_RS02130	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J15_RS02135	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J15_RS02150	COG3842	ATPase activity
I6J15_RS02165	COG1653	transport
I6J15_RS02170	COG1609	Transcriptional regulator
I6J15_RS02175	COG1363	Peptidase, m42
I6J15_RS02190	COG2190	(PTS) system
I6J15_RS02190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J15_RS02190	COG1263	PTS System
I6J15_RS02200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6J15_RS02225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6J15_RS02240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J15_RS02250	COG2017	converts alpha-aldose to the beta-anomer
I6J15_RS02260	COG4667	esterase of the alpha-beta hydrolase superfamily
I6J15_RS02285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6J15_RS02290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J15_RS02300	COG2223	nitrite transmembrane transporter activity
I6J15_RS02315	COG0564	pseudouridine synthase activity
I6J15_RS02340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6J15_RS02345	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6J15_RS02385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6J15_RS02390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6J15_RS02400	COG1363	Peptidase, m42
I6J15_RS02405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6J15_RS02460	COG4537	Required for transformation and DNA binding
I6J15_RS02465	COG1459	type II secretion system
I6J15_RS02470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6J15_RS02500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6J15_RS02505	COG1121	(ABC) transporter
I6J15_RS02515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6J15_RS02630	COG0203	ribosomal protein L17
I6J15_RS02635	COG0202	RNA polymerase activity
I6J15_RS02640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6J15_RS02665	COG0201	protein transport
I6J15_RS02675	COG1841	ribosomal large subunit assembly
I6J15_RS02680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6J15_RS02700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6J15_RS02710	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6J15_RS02725	COG0255	Belongs to the universal ribosomal protein uL29 family
I6J15_RS02755	COG0089	rRNA binding
I6J15_RS02760	COG0088	Forms part of the polypeptide exit tunnel
I6J15_RS02770	COG0051	transcription antitermination factor activity, RNA binding
I6J15_RS02775	COG0534	Mate efflux family protein
I6J15_RS02790	COG2755	lipolytic protein G-D-S-L family
I6J15_RS02790	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6J15_RS02800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6J15_RS02810	COG2255	four-way junction helicase activity
I6J15_RS02820	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6J15_RS02830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6J15_RS02835	COG1683	Conserved Protein
I6J15_RS02840	COG0151	Belongs to the GarS family
I6J15_RS02850	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6J15_RS02855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6J15_RS02865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6J15_RS02870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6J15_RS02875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J15_RS02880	COG0416	fatty acid biosynthetic process
I6J15_RS02890	COG0436	Aminotransferase
I6J15_RS02900	COG3942	CHAP domain
I6J15_RS02910	COG1792	Involved in formation and maintenance of cell shape
I6J15_RS03085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6J15_RS03115	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6J15_RS03125	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6J15_RS03135	COG0012	GTP binding
I6J15_RS03150	COG0592	DNA-directed DNA polymerase activity
I6J15_RS03160	COG1475	DNA binding
I6J15_RS03165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6J15_RS03200	COG0488	(ABC) transporter
I6J15_RS03215	COG0517	IMP dehydrogenase activity
I6J15_RS03215	COG0516	GMP reductase activity
I6J15_RS03225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6J15_RS03235	COG0612	Peptidase, M16
I6J15_RS03240	COG0612	Peptidase, M16
I6J15_RS03250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6J15_RS03260	COG1122	ATPase activity
I6J15_RS03330	COG1396	sequence-specific DNA binding
I6J15_RS03345	COG0741	lytic transglycosylase activity
I6J15_RS03355	COG1760	l-serine dehydratase
I6J15_RS03360	COG1760	l-serine dehydratase
I6J15_RS03370	COG0445	tRNA wobble uridine modification
I6J15_RS03385	COG0305	Participates in initiation and elongation during chromosome replication
I6J15_RS03390	COG4466	Protein conserved in bacteria
I6J15_RS03400	COG1309	transcriptional regulator
I6J15_RS03405	COG1511	domain protein
I6J15_RS03410	COG3759	membrane
I6J15_RS03420	COG3237	CsbD-like
I6J15_RS03440	COG2261	transglycosylase associated protein
I6J15_RS03455	COG1597	lipid kinase activity
I6J15_RS03495	COG4974	Belongs to the 'phage' integrase family
I6J15_RS03540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6J15_RS03560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J15_RS03565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6J15_RS03605	COG0519	Catalyzes the synthesis of GMP from XMP
I6J15_RS03615	COG1546	Belongs to the CinA family
I6J15_RS03615	COG1058	Belongs to the CinA family
I6J15_RS03625	COG1393	Belongs to the ArsC family
I6J15_RS03630	COG4472	Bacterial protein of unknown function (DUF965)
I6J15_RS03650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6J15_RS03650	COG1328	CTP reductase activity
I6J15_RS03665	COG0602	queuosine metabolic process
I6J15_RS03700	COG3590	peptidase
I6J15_RS03705	COG1396	sequence-specific DNA binding
I6J15_RS03735	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6J15_RS03750	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6J15_RS03760	COG4463	regulation of RNA biosynthetic process
I6J15_RS03765	COG0542	response to heat
I6J15_RS03770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6J15_RS03775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6J15_RS03790	COG2918	glutathione biosynthetic process
I6J15_RS03790	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6J15_RS03810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J15_RS03810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6J15_RS03815	COG1832	CoA-binding protein
I6J15_RS03830	COG0343	queuine tRNA-ribosyltransferase activity
I6J15_RS03835	COG1268	BioY protein
I6J15_RS03840	COG1234	tRNA 3'-trailer cleavage
I6J15_RS03855	COG0166	Belongs to the GPI family
I6J15_RS03890	COG2171	N-acyltransferase activity
I6J15_RS03900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6J15_RS03910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6J15_RS03925	COG0756	dUTP diphosphatase activity
I6J15_RS03940	COG4989	oxidoreductase activity
I6J15_RS03950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6J15_RS03955	COG2807	transmembrane transport
I6J15_RS03960	COG0137	argininosuccinate synthase activity
I6J15_RS03970	COG0594	ribonuclease P activity
I6J15_RS03990	COG1131	(ABC) transporter
I6J15_RS04020	COG2273	Hydrolase Family 16
I6J15_RS04045	COG0395	ABC-type sugar transport system, permease component
I6J15_RS04055	COG2273	Hydrolase Family 16
I6J15_RS04060	COG2207	Transcriptional regulator
I6J15_RS04065	COG0745	RESPONSE REGULATOR receiver
I6J15_RS04070	COG5002	protein histidine kinase activity
I6J15_RS04085	COG1696	Membrane protein involved in D-alanine export
I6J15_RS04090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6J15_RS04095	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6J15_RS04100	COG0583	DNA-binding transcription factor activity
I6J15_RS04105	COG0281	malic enzyme
I6J15_RS04150	COG0084	hydrolase, TatD family'
I6J15_RS04180	COG3290	protein histidine kinase activity
I6J15_RS04200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6J15_RS04205	COG1564	THIamine pyrophosphokinase
I6J15_RS04225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6J15_RS04235	COG0049	tRNA binding
I6J15_RS04240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6J15_RS04255	COG0126	phosphoglycerate kinase activity
I6J15_RS04265	COG0789	Transcriptional regulator
I6J15_RS04270	COG0174	glutamine synthetase
I6J15_RS04275	COG0067	glutamate synthase
I6J15_RS04275	COG0070	glutamate synthase
I6J15_RS04275	COG0069	glutamate synthase activity
I6J15_RS04280	COG0493	'glutamate synthase
I6J15_RS04305	COG1214	PFAM Peptidase M22, glycoprotease
I6J15_RS04310	COG0456	acetyltransferase
I6J15_RS04335	COG2081	HI0933 family
I6J15_RS04350	COG0789	Transcriptional regulator
I6J15_RS04365	COG0573	inorganic phosphate transmembrane transporter activity
I6J15_RS04370	COG0581	inorganic phosphate transmembrane transporter activity
I6J15_RS04375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J15_RS04380	COG0704	Plays a role in the regulation of phosphate uptake
I6J15_RS04390	COG5002	protein histidine kinase activity
I6J15_RS04410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6J15_RS04425	COG1882	Formate acetyltransferase
I6J15_RS04440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6J15_RS04445	COG0681	Belongs to the peptidase S26 family
I6J15_RS04450	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J15_RS04470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I6J15_RS04480	COG0157	Belongs to the NadC ModD family
I6J15_RS04490	COG3118	belongs to the thioredoxin family
I6J15_RS04515	COG1194	a g-specific adenine glycosylase
I6J15_RS04560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6J15_RS04575	COG3655	Transcriptional regulator
I6J15_RS04605	COG0006	proline dipeptidase activity
I6J15_RS04615	COG2131	deaminase
I6J15_RS04620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6J15_RS04630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6J15_RS04635	COG1609	Transcriptional regulator
I6J15_RS04640	COG1621	beta-fructofuranosidase activity
I6J15_RS04645	COG2190	(PTS) system
I6J15_RS04645	COG1263	PTS System
I6J15_RS04645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6J15_RS04650	COG1940	carbohydrate kinase activity
I6J15_RS04660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J15_RS04665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6J15_RS04670	COG0736	holo-[acyl-carrier-protein] synthase activity
I6J15_RS04675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6J15_RS04680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6J15_RS04700	COG3655	Transcriptional regulator
I6J15_RS04705	COG0252	asparaginase activity
I6J15_RS04710	COG0561	phosphatase activity
I6J15_RS04725	COG0436	Aminotransferase
I6J15_RS04730	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6J15_RS04735	COG1335	isochorismatase
I6J15_RS04740	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6J15_RS04745	COG0154	amidase activity
I6J15_RS04760	COG0697	spore germination
I6J15_RS04770	COG0477	Major facilitator Superfamily
I6J15_RS04780	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6J15_RS04785	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6J15_RS04790	COG1534	Rna-binding protein
I6J15_RS04795	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6J15_RS04800	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6J15_RS04805	COG1335	isochorismatase
I6J15_RS04810	COG0799	negative regulation of ribosome biogenesis
I6J15_RS04815	COG2226	methyltransferase
I6J15_RS04830	COG0217	transcriptional regulatory protein
I6J15_RS04835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6J15_RS04840	COG1473	amidohydrolase
I6J15_RS04845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J15_RS04870	COG1114	Component of the transport system for branched-chain amino acids
I6J15_RS04875	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6J15_RS04885	COG1122	ATPase activity
I6J15_RS04900	COG0569	domain protein
I6J15_RS04905	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J15_RS04915	COG1704	LemA family
I6J15_RS04920	COG0501	Belongs to the peptidase M48B family
I6J15_RS04930	COG0745	RESPONSE REGULATOR receiver
I6J15_RS04935	COG5002	protein histidine kinase activity
I6J15_RS04950	COG1484	DNA-dependent DNA replication
I6J15_RS04970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6J15_RS04980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6J15_RS05000	COG1254	Belongs to the acylphosphatase family
I6J15_RS05020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6J15_RS05040	COG3763	UPF0154 protein
I6J15_RS05045	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6J15_RS05065	COG0582	viral genome integration into host DNA
I6J15_RS05080	COG1187	pseudouridine synthase activity
I6J15_RS05085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6J15_RS05090	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6J15_RS05095	COG0569	domain protein
I6J15_RS05100	COG0531	amino acid
I6J15_RS05110	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6J15_RS05115	COG0671	phosphoesterase, PA-phosphatase related
I6J15_RS05120	COG1242	4 iron, 4 sulfur cluster binding
I6J15_RS05125	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6J15_RS05130	COG1119	ATPase activity
I6J15_RS05140	COG1253	flavin adenine dinucleotide binding
I6J15_RS05145	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6J15_RS05185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J15_RS05190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6J15_RS05195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6J15_RS05200	COG1120	ATPase activity
I6J15_RS05210	COG2244	polysaccharide biosynthetic process
I6J15_RS05215	COG0626	cystathionine gamma-synthase activity
I6J15_RS05220	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6J15_RS05235	COG0583	DNA-binding transcription factor activity
I6J15_RS05255	COG4471	UPF0298 protein
I6J15_RS05285	COG1227	inorganic diphosphatase activity
I6J15_RS05285	COG0517	IMP dehydrogenase activity
I6J15_RS05295	COG0470	DNA polymerase III
I6J15_RS05300	COG1774	PSP1 C-terminal conserved region
I6J15_RS05315	COG0004	ammonium transporteR
I6J15_RS05335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6J15_RS05340	COG1393	Belongs to the ArsC family
I6J15_RS05360	COG0708	Exodeoxyribonuclease III
I6J15_RS05365	COG0640	Transcriptional regulator
I6J15_RS05395	COG1028	Short-chain dehydrogenase reductase Sdr
I6J15_RS05410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6J15_RS05440	COG1674	ftsk spoiiie
I6J15_RS05470	COG2996	Protein conserved in bacteria
I6J15_RS05485	COG4479	Belongs to the UPF0346 family
I6J15_RS05490	COG1702	phosphate starvation-inducible protein PhoH
I6J15_RS05510	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6J15_RS05515	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6J15_RS05525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6J15_RS05530	COG0237	dephospho-CoA kinase activity
I6J15_RS05535	COG2814	Major facilitator Superfamily
I6J15_RS05550	COG0557	exoribonuclease II activity
I6J15_RS05565	COG1846	Transcriptional regulator
I6J15_RS05580	COG0778	Nitroreductase
I6J15_RS05600	COG0006	proline dipeptidase activity
I6J15_RS05605	COG1609	Transcriptional regulator
I6J15_RS05615	COG0438	transferase activity, transferring glycosyl groups
I6J15_RS05620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6J15_RS05630	COG4716	Myosin-crossreactive antigen
I6J15_RS05650	COG0745	RESPONSE REGULATOR receiver
I6J15_RS05655	COG5002	protein histidine kinase activity
I6J15_RS05655	COG3850	Histidine kinase
I6J15_RS05670	COG0765	amino acid transport
I6J15_RS05675	COG0765	amino acid transport
I6J15_RS05680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J15_RS05685	COG1126	abc transporter atp-binding protein
I6J15_RS05690	COG0745	RESPONSE REGULATOR receiver
I6J15_RS05695	COG5002	protein histidine kinase activity
I6J15_RS05700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6J15_RS05710	COG1196	nuclear chromosome segregation
I6J15_RS05720	COG0561	phosphatase activity
I6J15_RS05725	COG0561	phosphatase activity
I6J15_RS05730	COG0552	protein localization to endoplasmic reticulum
I6J15_RS05740	COG3689	TIGRFAM TIGR03943 family protein
I6J15_RS05745	COG0701	Predicted permease
I6J15_RS05755	COG2183	response to ionizing radiation
I6J15_RS05800	COG0826	peptidase U32
I6J15_RS05810	COG4443	Transcriptional Coactivator p15 (PC4)
I6J15_RS05820	COG1136	(ABC) transporter
I6J15_RS05820	COG0577	efflux transmembrane transporter activity
I6J15_RS05830	COG0745	RESPONSE REGULATOR receiver
I6J15_RS05855	COG0588	phosphoglycerate mutase activity
I6J15_RS05875	COG0386	Belongs to the glutathione peroxidase family
I6J15_RS05880	COG1164	Oligoendopeptidase f
I6J15_RS05890	COG0772	Belongs to the SEDS family
I6J15_RS05895	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6J15_RS05920	COG1078	dGTPase activity
I6J15_RS05945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6J15_RS05955	COG2884	Cell division ATP-binding protein ftsE
I6J15_RS05960	COG2177	Part of the ABC transporter FtsEX involved in
I6J15_RS05975	COG1199	ATP-dependent helicase activity
I6J15_RS05975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6J15_RS05985	COG0436	Aminotransferase
I6J15_RS05995	COG0017	Asparaginyl-tRNA synthetase
I6J15_RS06015	COG0251	oxidation-reduction process
I6J15_RS06025	COG1309	transcriptional regulator
I6J15_RS06035	COG1660	Displays ATPase and GTPase activities
I6J15_RS06065	COG1388	LysM domain
I6J15_RS06065	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J15_RS06075	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6J15_RS06090	COG0716	FMN binding
I6J15_RS06100	COG0398	Pfam SNARE associated Golgi protein
I6J15_RS06105	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6J15_RS06105	COG1605	Chorismate mutase
I6J15_RS06110	COG0038	chloride channel
I6J15_RS06125	COG0772	Belongs to the SEDS family
I6J15_RS06135	COG0187	DNA topoisomerase II activity
I6J15_RS06150	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6J15_RS06160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6J15_RS06165	COG0560	Phosphoserine phosphatase
I6J15_RS06175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6J15_RS06185	COG0107	imidazoleglycerol-phosphate synthase activity
I6J15_RS06205	COG1523	belongs to the glycosyl hydrolase 13 family
I6J15_RS06220	COG0148	phosphopyruvate hydratase activity
I6J15_RS06225	COG3442	glutamine amidotransferase
I6J15_RS06230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6J15_RS06235	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6J15_RS06250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6J15_RS06260	COG0647	UMP catabolic process
I6J15_RS06290	COG1518	maintenance of DNA repeat elements
I6J15_RS06305	COG0481	GTPase activity
I6J15_RS06310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6J15_RS06315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6J15_RS06320	COG0077	Prephenate dehydratase
I6J15_RS06325	COG1316	TRANSCRIPTIONal
I6J15_RS06335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6J15_RS06350	COG2608	mercury ion transmembrane transporter activity
I6J15_RS06370	COG0456	acetyltransferase
I6J15_RS06395	COG0590	tRNA wobble adenosine to inosine editing
I6J15_RS06410	COG0659	secondary active sulfate transmembrane transporter activity
I6J15_RS06415	COG4166	transmembrane transport
I6J15_RS06420	COG4166	transmembrane transport
I6J15_RS06425	COG1187	pseudouridine synthase activity
I6J15_RS06450	COG1126	abc transporter atp-binding protein
I6J15_RS06455	COG0765	amino acid transport
I6J15_RS06460	COG0556	nucleotide-excision repair
I6J15_RS06470	COG3833	ABC-type maltose transport systems, permease component
I6J15_RS06475	COG1175	transmembrane transport
I6J15_RS06485	COG1609	Transcriptional regulator
I6J15_RS06490	COG1640	4-alpha-glucanotransferase
I6J15_RS06495	COG0058	SHG alpha-glucan phosphorylase activity
I6J15_RS06505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J15_RS06530	COG1970	mechanosensitive ion channel activity
I6J15_RS06535	COG0358	DNA primase activity
I6J15_RS06540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6J15_RS06545	COG2151	metal-sulfur cluster biosynthetic enzyme
I6J15_RS06555	COG1216	Glycosyl transferase, family 2
I6J15_RS06555	COG1442	glycosyl transferase family 8
I6J15_RS06570	COG1216	Glycosyl transferase, family 2
I6J15_RS06570	COG1442	glycosyl transferase family 8
I6J15_RS06580	COG1368	sulfuric ester hydrolase activity
I6J15_RS06595	COG0463	Glycosyl transferase, family 2
I6J15_RS06615	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6J15_RS06640	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6J15_RS06645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6J15_RS06650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6J15_RS06655	COG1368	sulfuric ester hydrolase activity
I6J15_RS06660	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6J15_RS06670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6J15_RS06675	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6J15_RS06685	COG0287	Prephenate dehydrogenase
I6J15_RS06700	COG0285	dihydrofolate synthase activity
I6J15_RS06710	COG1104	cysteine desulfurase activity
I6J15_RS06715	COG0301	tRNA thio-modification
I6J15_RS06740	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6J15_RS06745	COG0583	DNA-binding transcription factor activity
I6J15_RS06755	COG0564	pseudouridine synthase activity
I6J15_RS06770	COG0540	Belongs to the ATCase OTCase family
I6J15_RS06775	COG0505	Belongs to the CarA family
I6J15_RS06790	COG1136	(ABC) transporter
I6J15_RS06795	COG0577	efflux transmembrane transporter activity
I6J15_RS06820	COG1837	Belongs to the UPF0109 family
I6J15_RS06835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6J15_RS06845	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6J15_RS06850	COG0492	ferredoxin-NADP+ reductase activity
I6J15_RS06855	COG1349	DNA-binding transcription factor activity
I6J15_RS06860	COG1105	Belongs to the carbohydrate kinase PfkB family
I6J15_RS06865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J15_RS06865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J15_RS06865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6J15_RS06870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6J15_RS06875	COG0646	methionine synthase
I6J15_RS06875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6J15_RS06880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6J15_RS06885	COG1388	LysM domain
I6J15_RS06885	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6J15_RS06910	COG0488	(ABC) transporter
I6J15_RS06925	COG1132	(ABC) transporter
I6J15_RS06945	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6J15_RS06955	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6J15_RS06965	COG0242	peptide deformylase activity
I6J15_RS06980	COG1132	(ABC) transporter
I6J15_RS06985	COG2357	RelA SpoT domain protein
I6J15_RS06990	COG0745	RESPONSE REGULATOR receiver
I6J15_RS06995	COG5002	protein histidine kinase activity
I6J15_RS07000	COG0656	L-ascorbic acid biosynthetic process
I6J15_RS07005	COG0583	DNA-binding transcription factor activity
I6J15_RS07015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6J15_RS07020	COG0765	amino acid transport
I6J15_RS07025	COG0765	amino acid transport
I6J15_RS07030	COG1126	abc transporter atp-binding protein
I6J15_RS07035	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6J15_RS07055	COG1272	protein, Hemolysin III
I6J15_RS07070	COG3425	synthase
I6J15_RS07075	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6J15_RS07080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6J15_RS07120	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6J15_RS07155	COG2962	Rard protein
I6J15_RS07165	COG0285	dihydrofolate synthase activity
I6J15_RS07185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6J15_RS07190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6J15_RS07200	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6J15_RS07205	COG1177	transmembrane transport
I6J15_RS07235	COG2207	Transcriptional regulator
I6J15_RS07250	COG2723	6-phospho-beta-galactosidase activity
I6J15_RS07275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J15_RS07280	COG3711	transcriptional antiterminator
I6J15_RS07280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6J15_RS07285	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6J15_RS07295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6J15_RS07300	COG0561	phosphatase activity
I6J15_RS07325	COG0577	efflux transmembrane transporter activity
I6J15_RS07330	COG1136	(ABC) transporter
I6J15_RS07335	COG0577	efflux transmembrane transporter activity
I6J15_RS07340	COG0745	RESPONSE REGULATOR receiver
I6J15_RS07345	COG5002	protein histidine kinase activity
I6J15_RS07360	COG0561	phosphatase activity
I6J15_RS07365	COG1115	amino acid carrier protein
I6J15_RS07385	COG0210	DNA helicase
I6J15_RS07410	COG0577	efflux transmembrane transporter activity
I6J15_RS07410	COG1136	(ABC) transporter
I6J15_RS07440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6J15_RS07445	COG0196	riboflavin kinase activity
I6J15_RS07450	COG1393	Belongs to the ArsC family
I6J15_RS07460	COG0483	inositol monophosphate 1-phosphatase activity
I6J15_RS07480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6J15_RS07485	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6J15_RS07485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6J15_RS07495	COG0573	inorganic phosphate transmembrane transporter activity
I6J15_RS07500	COG0581	inorganic phosphate transmembrane transporter activity
I6J15_RS07505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J15_RS07510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6J15_RS07515	COG0704	Plays a role in the regulation of phosphate uptake
I6J15_RS07525	COG0745	RESPONSE REGULATOR receiver
I6J15_RS07530	COG5002	protein histidine kinase activity
I6J15_RS07545	COG1072	(Pantothenic acid kinase))
I6J15_RS07550	COG2813	Specifically methylates the guanine in position
I6J15_RS07560	COG1744	ABC transporter substrate-binding protein PnrA-like
I6J15_RS07565	COG3845	ABC transporter
I6J15_RS07570	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6J15_RS07575	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6J15_RS07595	COG3764	Sortase (surface protein transpeptidase)
I6J15_RS07600	COG0346	lactoylglutathione lyase activity
I6J15_RS07620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6J15_RS07625	COG4684	Psort location CytoplasmicMembrane, score
I6J15_RS07630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J15_RS07635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6J15_RS07645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6J15_RS07650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6J15_RS07655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6J15_RS07660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6J15_RS07675	COG0488	(ABC) transporter
I6J15_RS07680	COG1131	(ABC) transporter
I6J15_RS07720	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6J15_RS07725	COG0110	maltose O-acetyltransferase activity
I6J15_RS07730	COG0758	DNA mediated transformation
I6J15_RS07735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6J15_RS07760	COG1136	(ABC) transporter
I6J15_RS07765	COG0577	efflux transmembrane transporter activity
I6J15_RS07770	COG0745	RESPONSE REGULATOR receiver
I6J15_RS07775	COG2205	protein histidine kinase activity
I6J15_RS07780	COG1395	domain, Protein
I6J15_RS07785	COG4974	Belongs to the 'phage' integrase family
I6J15_RS07810	COG2720	vancomycin resistance protein
I6J15_RS07825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6J15_RS07835	COG2188	Transcriptional regulator
I6J15_RS07865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6J15_RS07890	COG0534	Mate efflux family protein
I6J15_RS07910	COG0519	Catalyzes the synthesis of GMP from XMP
I6J15_RS07910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6J15_RS07920	COG1418	mRNA catabolic process
I6J15_RS07925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6J15_RS07955	COG0095	Lipoate-protein ligase
I6J15_RS07975	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J15_RS07980	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6J15_RS07980	COG0022	dehydrogenase e1 component
I6J15_RS07985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6J15_RS08000	COG1132	(ABC) transporter
I6J15_RS08020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6J15_RS08025	COG0009	L-threonylcarbamoyladenylate synthase
I6J15_RS08030	COG2890	protein-(glutamine-N5) methyltransferase activity
I6J15_RS08035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6J15_RS08060	COG2233	PERMEase
I6J15_RS08080	COG1136	(ABC) transporter
I6J15_RS08085	COG2723	6-phospho-beta-galactosidase activity
I6J15_RS08090	COG0561	phosphatase activity
I6J15_RS08100	COG4221	oxidoreductase activity
I6J15_RS08105	COG0280	phosphate acetyltransferase
I6J15_RS08110	COG0564	pseudouridine synthase activity
I6J15_RS08120	COG2357	RelA SpoT domain protein
I6J15_RS08125	COG4116	CYTH
I6J15_RS08135	COG1104	cysteine desulfurase activity
I6J15_RS08155	COG0628	permease
I6J15_RS08170	COG1115	amino acid carrier protein
I6J15_RS08175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6J15_RS08185	COG1126	abc transporter atp-binding protein
I6J15_RS08190	COG0765	amino acid transport
I6J15_RS08195	COG2824	Alkylphosphonate utilization operon protein PhnA
I6J15_RS08205	COG0681	Belongs to the peptidase S26 family
I6J15_RS08210	COG0469	pyruvate kinase activity
I6J15_RS08215	COG0205	6-phosphofructokinase activity
I6J15_RS08225	COG1725	Transcriptional regulator
I6J15_RS08230	COG1131	(ABC) transporter
I6J15_RS08250	COG1380	Effector of murein hydrolase LrgA
I6J15_RS08255	COG1346	cytolysis
I6J15_RS08265	COG0539	negative regulation of cytoplasmic translation
I6J15_RS08285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6J15_RS08290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6J15_RS08295	COG0187	DNA topoisomerase II activity
I6J15_RS08315	COG1881	PFAM PEBP family protein
I6J15_RS08325	COG0284	orotidine-5'-phosphate decarboxylase activity
I6J15_RS08330	COG0167	dihydroorotate dehydrogenase activity
I6J15_RS08355	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6J15_RS08370	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J15_RS08380	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J15_RS08390	COG2244	polysaccharide biosynthetic process
I6J15_RS08405	COG0463	Glycosyl transferase, family 2
I6J15_RS08410	COG0438	transferase activity, transferring glycosyl groups
I6J15_RS08425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6J15_RS08435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6J15_RS08455	COG1316	TRANSCRIPTIONal
I6J15_RS08480	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6J15_RS08500	COG1573	uracil-dna glycosylase
I6J15_RS08525	COG0322	excinuclease ABC activity
I6J15_RS08530	COG1012	belongs to the aldehyde dehydrogenase family
I6J15_RS08535	COG2855	membrane
I6J15_RS08540	COG0583	DNA-binding transcription factor activity
I6J15_RS08550	COG1011	Hydrolase
I6J15_RS08555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6J15_RS08560	COG1136	(ABC) transporter
I6J15_RS08590	COG0789	Transcriptional regulator
I6J15_RS08600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6J15_RS08610	COG2814	Major facilitator Superfamily
I6J15_RS08620	COG1132	(ABC) transporter
I6J15_RS08625	COG1132	(ABC) transporter
I6J15_RS08635	COG0488	(ABC) transporter
I6J15_RS08650	COG3842	ATPase activity
I6J15_RS08655	COG4120	Belongs to the binding-protein-dependent transport system permease family
I6J15_RS08675	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6J15_RS08680	COG0531	amino acid
I6J15_RS08685	COG3527	Alpha-acetolactate decarboxylase
I6J15_RS08690	COG0028	Belongs to the TPP enzyme family
I6J15_RS08700	COG0457	Tetratricopeptide repeat
I6J15_RS08705	COG0628	permease
I6J15_RS08710	COG1051	belongs to the nudix hydrolase family
I6J15_RS08715	COG1088	dTDP-glucose 4,6-dehydratase activity
I6J15_RS08725	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6J15_RS08735	COG2384	SAM-dependent methyltransferase
I6J15_RS08740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6J15_RS08760	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6J15_RS08765	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6J15_RS08765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6J15_RS08770	COG0300	oxidoreductase activity
I6J15_RS08785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6J15_RS08820	COG1074	ATP-dependent DNA helicase activity
I6J15_RS08825	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6J15_RS08840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6J15_RS08855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6J15_RS08905	COG1597	lipid kinase activity
I6J15_RS08910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6J15_RS08915	COG4708	membrane
I6J15_RS08920	COG2246	polysaccharide biosynthetic process