locus-tag	class	description
SMA_RS00010	COG0592	DNA-directed DNA polymerase activity
SMA_RS00015	COG1597	lipid kinase activity
SMA_RS00025	COG0012	GTP binding
SMA_RS00035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMA_RS00040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMA_RS00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMA_RS00200	COG1792	Involved in formation and maintenance of cell shape
SMA_RS00210	COG3942	CHAP domain
SMA_RS00220	COG0436	Aminotransferase
SMA_RS00230	COG0416	fatty acid biosynthetic process
SMA_RS00235	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMA_RS00240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMA_RS00245	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMA_RS00255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMA_RS00260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMA_RS00285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMA_RS00305	COG0534	Mate efflux family protein
SMA_RS00320	COG2197	response regulator
SMA_RS00335	COG0051	transcription antitermination factor activity, RNA binding
SMA_RS00345	COG0088	Forms part of the polypeptide exit tunnel
SMA_RS00350	COG0089	rRNA binding
SMA_RS00380	COG0255	Belongs to the universal ribosomal protein uL29 family
SMA_RS00395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMA_RS00405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMA_RS00425	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMA_RS00430	COG1841	ribosomal large subunit assembly
SMA_RS00435	COG0200	Binds to the 23S rRNA
SMA_RS00440	COG0201	protein transport
SMA_RS00445	COG0563	adenylate kinase activity
SMA_RS00460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMA_RS00465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMA_RS00470	COG0202	RNA polymerase activity
SMA_RS00475	COG0203	ribosomal protein L17
SMA_RS00645	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMA_RS00655	COG1121	(ABC) transporter
SMA_RS00660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMA_RS00690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMA_RS00695	COG1459	type II secretion system
SMA_RS00700	COG4537	Required for transformation and DNA binding
SMA_RS00750	COG1266	CAAX protease self-immunity
SMA_RS00760	COG0151	Belongs to the GarS family
SMA_RS00765	COG1683	Conserved Protein
SMA_RS00770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMA_RS00785	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMA_RS00790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMA_RS00795	COG1363	Peptidase, m42
SMA_RS00805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMA_RS00810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMA_RS00820	COG2391	methyltransferase activity
SMA_RS00825	COG0425	Belongs to the sulfur carrier protein TusA family
SMA_RS00830	COG0561	phosphatase activity
SMA_RS00840	COG4585	Histidine kinase
SMA_RS00845	COG2197	response regulator
SMA_RS00865	COG3715	PTS system
SMA_RS00870	COG3716	PTS system mannose fructose sorbose family IID component
SMA_RS00880	COG4120	Belongs to the binding-protein-dependent transport system permease family
SMA_RS00885	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMA_RS00895	COG0459	protein refolding
SMA_RS00900	COG1396	sequence-specific DNA binding
SMA_RS00915	COG0564	pseudouridine synthase activity
SMA_RS00930	COG2223	nitrite transmembrane transporter activity
SMA_RS00945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMA_RS00965	COG4667	esterase of the alpha-beta hydrolase superfamily
SMA_RS00985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMA_RS00995	COG0436	Aminotransferase
SMA_RS01040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMA_RS01065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMA_RS01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMA_RS01075	COG2190	(PTS) system
SMA_RS01075	COG1263	PTS System
SMA_RS01085	COG1363	Peptidase, m42
SMA_RS01110	COG2188	Transcriptional regulator
SMA_RS01115	COG1482	cell wall glycoprotein biosynthetic process
SMA_RS01130	COG0395	ABC-type sugar transport system, permease component
SMA_RS01145	COG2188	Transcriptional regulator
SMA_RS01180	COG3842	ATPase activity
SMA_RS01190	COG0698	ribose 5-phosphate isomerase
SMA_RS01220	COG3775	system Galactitol-specific IIC component
SMA_RS01230	COG3711	transcriptional antiterminator
SMA_RS01235	COG2723	6-phospho-beta-galactosidase activity
SMA_RS01240	COG3711	transcriptional antiterminator
SMA_RS01270	COG2207	Transcriptional regulator
SMA_RS01275	COG3345	alpha-galactosidase
SMA_RS01280	COG1653	transport
SMA_RS01285	COG1175	transmembrane transport
SMA_RS01290	COG0395	ABC-type sugar transport system, permease component
SMA_RS01295	COG0366	Alpha amylase catalytic
SMA_RS01300	COG0366	Alpha amylase catalytic
SMA_RS01305	COG1609	Transcriptional regulator
SMA_RS01310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMA_RS01315	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SMA_RS01320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMA_RS01330	COG1862	Preprotein translocase
SMA_RS01335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMA_RS01340	COG4589	Belongs to the CDS family
SMA_RS01370	COG0242	peptide deformylase activity
SMA_RS01385	COG0346	lactoylglutathione lyase activity
SMA_RS01415	COG1185	polyribonucleotide nucleotidyltransferase activity
SMA_RS01425	COG1045	serine acetyltransferase
SMA_RS01435	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SMA_RS01460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMA_RS01485	COG5290	Psort location Cytoplasmic, score
SMA_RS01505	COG2801	Transposase and inactivated derivatives
SMA_RS01520	COG2217	Heavy metal translocating P-type atpase
SMA_RS01525	COG2217	Heavy metal translocating P-type atpase
SMA_RS01575	COG3830	Belongs to the UPF0237 family
SMA_RS01580	COG2848	UPF0210 protein
SMA_RS01585	COG0588	phosphoglycerate mutase activity
SMA_RS01595	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMA_RS01605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMA_RS01625	COG0352	thiamine-phosphate diphosphorylase activity
SMA_RS01625	COG0351	phosphomethylpyrimidine kinase
SMA_RS01640	COG0668	transmembrane transport
SMA_RS01655	COG0504	CTP synthase activity
SMA_RS01675	COG0191	fructose-bisphosphate aldolase activity
SMA_RS01700	COG0582	viral genome integration into host DNA
SMA_RS01725	COG2217	Heavy metal translocating P-type atpase
SMA_RS01745	COG0640	Transcriptional regulator
SMA_RS01750	COG2217	Heavy metal translocating P-type atpase
SMA_RS01760	COG3237	CsbD-like
SMA_RS01780	COG2261	transglycosylase associated protein
SMA_RS01810	COG1611	Belongs to the LOG family
SMA_RS01825	COG1174	glycine betaine transport
SMA_RS01840	COG3328	transposase activity
SMA_RS01850	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMA_RS01860	COG1461	Dihydroxyacetone kinase
SMA_RS01865	COG0129	dihydroxy-acid dehydratase activity
SMA_RS01870	COG0028	Belongs to the TPP enzyme family
SMA_RS01875	COG0440	acetolactate synthase activity
SMA_RS01880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMA_RS01885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMA_RS01900	COG1126	abc transporter atp-binding protein
SMA_RS01905	COG0765	amino acid transport
SMA_RS01925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMA_RS01935	COG0719	Fe-S assembly protein
SMA_RS01940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMA_RS01950	COG0719	Fe-S assembly protein
SMA_RS01955	COG1686	Belongs to the peptidase S11 family
SMA_RS01960	COG4166	transmembrane transport
SMA_RS01965	COG0601	transmembrane transport
SMA_RS01970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMA_RS01975	COG0444	Belongs to the ABC transporter superfamily
SMA_RS01980	COG4608	Belongs to the ABC transporter superfamily
SMA_RS02015	COG0527	aspartate kinase activity
SMA_RS02020	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SMA_RS02025	COG1024	Enoyl-CoA hydratase
SMA_RS02035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMA_RS02045	COG2070	2-Nitropropane dioxygenase
SMA_RS02050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMA_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
SMA_RS02060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMA_RS02075	COG0439	Biotin carboxylase
SMA_RS02090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMA_RS02100	COG3716	PTS system mannose fructose sorbose family IID component
SMA_RS02105	COG3715	PTS system
SMA_RS02115	COG0561	phosphatase activity
SMA_RS02130	COG2252	PERMEase
SMA_RS02135	COG0802	atpase or kinase
SMA_RS02145	COG1316	TRANSCRIPTIONal
SMA_RS02155	COG0537	adenosine 5'-monophosphoramidase activity
SMA_RS02160	COG1131	(ABC) transporter
SMA_RS02165	COG4473	ABC transporter
SMA_RS02175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMA_RS02205	COG0195	Participates in both transcription termination and antitermination
SMA_RS02210	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SMA_RS02220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMA_RS02225	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMA_RS02245	COG2217	Heavy metal translocating P-type atpase
SMA_RS02255	COG2860	membrane
SMA_RS02260	COG0561	phosphatase activity
SMA_RS02330	COG1131	(ABC) transporter
SMA_RS02340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMA_RS02360	COG0768	penicillin binding
SMA_RS02365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMA_RS02375	COG0513	Belongs to the DEAD box helicase family
SMA_RS02385	COG0765	amino acid transport
SMA_RS02390	COG1126	abc transporter atp-binding protein
SMA_RS02405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SMA_RS02410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMA_RS02415	COG3579	cysteine-type endopeptidase activity
SMA_RS02420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMA_RS02425	COG3331	DNA recombination
SMA_RS02440	COG0116	Belongs to the methyltransferase superfamily
SMA_RS02465	COG1854	S-ribosylhomocysteine lyase activity
SMA_RS02485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMA_RS02495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMA_RS02495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMA_RS02505	COG0515	serine threonine protein kinase
SMA_RS02505	COG2815	serine threonine protein kinase
SMA_RS02515	COG4585	Histidine kinase
SMA_RS02520	COG2197	response regulator
SMA_RS02530	COG1098	S1 RNA binding domain
SMA_RS02540	COG1739	Uncharacterized protein family UPF0029
SMA_RS02545	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SMA_RS02550	COG1040	competence protein
SMA_RS02620	COG3557	Belongs to the UPF0374 family
SMA_RS02625	COG2137	regulation of response to DNA damage stimulus
SMA_RS02635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMA_RS02655	COG2217	Heavy metal translocating P-type atpase
SMA_RS02665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMA_RS02685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMA_RS02690	COG1780	Probably involved in ribonucleotide reductase function
SMA_RS02695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMA_RS02720	COG1247	-acetyltransferase
SMA_RS02735	COG1428	Deoxynucleoside kinase
SMA_RS02765	COG0519	Catalyzes the synthesis of GMP from XMP
SMA_RS02775	COG0525	valine-tRNA ligase activity
SMA_RS02815	COG0742	ribosomal rna small subunit methyltransferase
SMA_RS02820	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMA_RS02825	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMA_RS02850	COG0737	Belongs to the 5'-nucleotidase family
SMA_RS02855	COG4470	Protein conserved in bacteria
SMA_RS02870	COG1132	(ABC) transporter
SMA_RS02875	COG1132	(ABC) transporter
SMA_RS02880	COG1131	(ABC) transporter
SMA_RS02890	COG4585	Histidine kinase
SMA_RS02895	COG2197	response regulator
SMA_RS02915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMA_RS02920	COG0512	Glutamine amidotransferase of anthranilate synthase
SMA_RS02930	COG0134	indole-3-glycerol-phosphate synthase activity
SMA_RS02935	COG0135	phosphoribosylanthranilate isomerase activity
SMA_RS02940	COG0133	tryptophan synthase activity
SMA_RS02945	COG0159	tryptophan synthase activity
SMA_RS02950	COG1914	H( )-stimulated, divalent metal cation uptake system
SMA_RS02960	COG0783	Belongs to the Dps family
SMA_RS02970	COG1940	carbohydrate kinase activity
SMA_RS03005	COG1217	gtp-binding protein TYPA
SMA_RS03040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMA_RS03045	COG1799	cell septum assembly
SMA_RS03060	COG3599	regulation of cell shape
SMA_RS03080	COG0542	response to heat
SMA_RS03090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMA_RS03095	COG4703	Protein of unknown function (DUF1797)
SMA_RS03100	COG0765	amino acid transport
SMA_RS03105	COG1126	abc transporter atp-binding protein
SMA_RS03130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMA_RS03160	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SMA_RS03165	COG1438	arginine binding
SMA_RS03170	COG0497	DNA recombination
SMA_RS03175	COG1307	EDD domain protein, DegV family
SMA_RS03180	COG2755	lipolytic protein G-D-S-L family
SMA_RS03185	COG4698	Protein conserved in bacteria
SMA_RS03200	COG3104	oligopeptide transport
SMA_RS03205	COG0167	dihydroorotate dehydrogenase activity
SMA_RS03215	COG0640	Transcriptional regulator
SMA_RS03220	COG2217	Heavy metal translocating P-type atpase
SMA_RS03225	COG2076	Multidrug Resistance protein
SMA_RS03235	COG1827	regulation of RNA biosynthetic process
SMA_RS03245	COG0768	penicillin binding
SMA_RS03250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMA_RS03255	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMA_RS03265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMA_RS03280	COG0513	Belongs to the DEAD box helicase family
SMA_RS03290	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMA_RS03295	COG0204	Acyl-transferase
SMA_RS03300	COG1596	polysaccharide export
SMA_RS03300	COG1555	photosystem II stabilization
SMA_RS03305	COG2333	competence protein COMEC
SMA_RS03305	COG0658	competence protein
SMA_RS03310	COG1466	dna polymerase III delta subunit
SMA_RS03315	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMA_RS03320	COG0217	transcriptional regulatory protein
SMA_RS03335	COG0363	glucosamine-6-phosphate deaminase activity
SMA_RS03340	COG1187	pseudouridine synthase activity
SMA_RS03360	COG0546	phosphoglycolate phosphatase activity
SMA_RS03365	COG4122	O-methyltransferase activity
SMA_RS03375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMA_RS03390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMA_RS03395	COG0436	Aminotransferase
SMA_RS03405	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMA_RS03410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMA_RS03415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMA_RS03430	COG3859	Proton-coupled thiamine transporter YuaJ
SMA_RS03435	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMA_RS03440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMA_RS03445	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMA_RS03450	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMA_RS03455	COG0372	Belongs to the citrate synthase family
SMA_RS03475	COG1609	Transcriptional regulator
SMA_RS03485	COG0251	oxidation-reduction process
SMA_RS03495	COG1309	transcriptional regulator
SMA_RS03510	COG1660	Displays ATPase and GTPase activities
SMA_RS03565	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMA_RS03565	COG1388	LysM domain
SMA_RS03580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SMA_RS03620	COG0513	Belongs to the DEAD box helicase family
SMA_RS03645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMA_RS03650	COG0066	3-isopropylmalate dehydratase activity
SMA_RS03655	COG1956	GAF domain-containing protein
SMA_RS03660	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMA_RS03670	COG2801	Transposase and inactivated derivatives
SMA_RS03680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMA_RS03685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMA_RS03695	COG4109	DRTGG domain
SMA_RS03700	COG0024	Methionine aminopeptidase
SMA_RS03710	COG2246	polysaccharide biosynthetic process
SMA_RS03715	COG4708	membrane
SMA_RS03720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMA_RS03725	COG1597	lipid kinase activity
SMA_RS03740	COG0058	SHG alpha-glucan phosphorylase activity
SMA_RS03750	COG0356	it plays a direct role in the translocation of protons across the membrane
SMA_RS03775	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMA_RS03790	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMA_RS03810	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMA_RS03815	COG0456	acetyltransferase
SMA_RS03825	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SMA_RS03830	COG1074	ATP-dependent DNA helicase activity
SMA_RS03850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMA_RS03865	COG0300	oxidoreductase activity
SMA_RS03870	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMA_RS03870	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SMA_RS03915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMA_RS03920	COG2384	SAM-dependent methyltransferase
SMA_RS03930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SMA_RS03935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMA_RS03945	COG1088	dTDP-glucose 4,6-dehydratase activity
SMA_RS03955	COG1051	belongs to the nudix hydrolase family
SMA_RS03960	COG0628	permease
SMA_RS03965	COG0457	Tetratricopeptide repeat
SMA_RS03975	COG0640	Transcriptional regulator
SMA_RS03980	COG1902	pentaerythritol trinitrate reductase activity
SMA_RS03985	COG0028	Belongs to the TPP enzyme family
SMA_RS03990	COG3527	Alpha-acetolactate decarboxylase
SMA_RS03995	COG0531	amino acid
SMA_RS04000	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SMA_RS04005	COG0583	DNA-binding transcription factor activity
SMA_RS04010	COG1126	abc transporter atp-binding protein
SMA_RS04015	COG0765	amino acid transport
SMA_RS04020	COG4187	Peptidase family M20/M25/M40
SMA_RS04030	COG4120	Belongs to the binding-protein-dependent transport system permease family
SMA_RS04035	COG3842	ATPase activity
SMA_RS04060	COG0488	(ABC) transporter
SMA_RS04085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMA_RS04090	COG0022	dehydrogenase e1 component
SMA_RS04090	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMA_RS04125	COG0095	Lipoate-protein ligase
SMA_RS04155	COG1937	Protein conserved in bacteria
SMA_RS04165	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMA_RS04175	COG1418	mRNA catabolic process
SMA_RS04190	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMA_RS04225	COG1011	Hydrolase
SMA_RS04235	COG0583	DNA-binding transcription factor activity
SMA_RS04240	COG2855	membrane
SMA_RS04245	COG1012	belongs to the aldehyde dehydrogenase family
SMA_RS04255	COG0322	excinuclease ABC activity
SMA_RS04285	COG1573	uracil-dna glycosylase
SMA_RS04290	COG0577	efflux transmembrane transporter activity
SMA_RS04295	COG1136	(ABC) transporter
SMA_RS04300	COG1573	uracil-dna glycosylase
SMA_RS04320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SMA_RS04325	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMA_RS04360	COG1316	TRANSCRIPTIONal
SMA_RS04370	COG3944	biosynthesis protein
SMA_RS04385	COG2244	polysaccharide biosynthetic process
SMA_RS04390	COG0562	UDP-galactopyranose mutase
SMA_RS04400	COG0297	glycogen (starch) synthase activity
SMA_RS04415	COG0438	transferase activity, transferring glycosyl groups
SMA_RS04445	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMA_RS04460	COG0167	dihydroorotate dehydrogenase activity
SMA_RS04465	COG0284	orotidine-5'-phosphate decarboxylase activity
SMA_RS04470	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMA_RS04480	COG1881	PFAM PEBP family protein
SMA_RS04500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMA_RS04505	COG0187	DNA topoisomerase II activity
SMA_RS04510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SMA_RS04515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMA_RS04535	COG0539	negative regulation of cytoplasmic translation
SMA_RS04545	COG1346	cytolysis
SMA_RS04550	COG1380	Effector of murein hydrolase LrgA
SMA_RS04565	COG1131	(ABC) transporter
SMA_RS04570	COG1725	Transcriptional regulator
SMA_RS04580	COG0205	6-phosphofructokinase activity
SMA_RS04585	COG0469	pyruvate kinase activity
SMA_RS04625	COG4720	Psort location CytoplasmicMembrane, score
SMA_RS04630	COG1054	Belongs to the UPF0176 family
SMA_RS04635	COG1122	ATPase activity
SMA_RS04655	COG3711	transcriptional antiterminator
SMA_RS04660	COG2824	Alkylphosphonate utilization operon protein PhnA
SMA_RS04665	COG0765	amino acid transport
SMA_RS04670	COG1126	abc transporter atp-binding protein
SMA_RS04680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMA_RS04690	COG1115	amino acid carrier protein
SMA_RS04705	COG0406	alpha-ribazole phosphatase activity
SMA_RS04715	COG0628	permease
SMA_RS04720	COG1442	glycosyl transferase family 8
SMA_RS04730	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMA_RS04740	COG1104	cysteine desulfurase activity
SMA_RS04755	COG2357	RelA SpoT domain protein
SMA_RS04765	COG0564	pseudouridine synthase activity
SMA_RS04770	COG0280	phosphate acetyltransferase
SMA_RS04775	COG4221	oxidoreductase activity
SMA_RS04815	COG0516	GMP reductase activity
SMA_RS04830	COG2233	PERMEase
SMA_RS04860	COG2890	protein-(glutamine-N5) methyltransferase activity
SMA_RS04865	COG0009	L-threonylcarbamoyladenylate synthase
SMA_RS04885	COG1132	(ABC) transporter
SMA_RS04890	COG1132	(ABC) transporter
SMA_RS04910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SMA_RS04910	COG0519	Catalyzes the synthesis of GMP from XMP
SMA_RS04915	COG2189	Belongs to the N(4) N(6)-methyltransferase family
SMA_RS04920	COG3421	Type III restriction
SMA_RS04975	COG0534	Mate efflux family protein
SMA_RS04990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMA_RS05005	COG2188	Transcriptional regulator
SMA_RS05020	COG4115	mRNA cleavage
SMA_RS05030	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SMA_RS05035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMA_RS05050	COG4974	Belongs to the 'phage' integrase family
SMA_RS05060	COG5002	protein histidine kinase activity
SMA_RS05065	COG0745	RESPONSE REGULATOR receiver
SMA_RS05070	COG0577	efflux transmembrane transporter activity
SMA_RS05075	COG1136	(ABC) transporter
SMA_RS05085	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SMA_RS05100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMA_RS05105	COG0758	DNA mediated transformation
SMA_RS05110	COG0110	maltose O-acetyltransferase activity
SMA_RS05115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMA_RS05120	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMA_RS05140	COG0488	(ABC) transporter
SMA_RS05155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMA_RS05160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMA_RS05165	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMA_RS05170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMA_RS05185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMA_RS05190	COG4684	Psort location CytoplasmicMembrane, score
SMA_RS05195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMA_RS05210	COG0346	lactoylglutathione lyase activity
SMA_RS05215	COG3764	Sortase (surface protein transpeptidase)
SMA_RS05250	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMA_RS05255	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMA_RS05260	COG3845	ABC transporter
SMA_RS05265	COG1744	ABC transporter substrate-binding protein PnrA-like
SMA_RS05270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMA_RS05275	COG2813	Specifically methylates the guanine in position
SMA_RS05280	COG1072	(Pantothenic acid kinase))
SMA_RS05290	COG5002	protein histidine kinase activity
SMA_RS05295	COG0745	RESPONSE REGULATOR receiver
SMA_RS05310	COG0704	Plays a role in the regulation of phosphate uptake
SMA_RS05315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMA_RS05320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMA_RS05325	COG0581	inorganic phosphate transmembrane transporter activity
SMA_RS05330	COG0573	inorganic phosphate transmembrane transporter activity
SMA_RS05350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMA_RS05370	COG0519	Catalyzes the synthesis of GMP from XMP
SMA_RS05375	COG0483	inositol monophosphate 1-phosphatase activity
SMA_RS05380	COG4476	Belongs to the UPF0223 family
SMA_RS05385	COG1393	Belongs to the ArsC family
SMA_RS05390	COG0196	riboflavin kinase activity
SMA_RS05395	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMA_RS05450	COG2873	o-acetylhomoserine
SMA_RS05480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMA_RS05485	COG1115	amino acid carrier protein
SMA_RS05510	COG0561	phosphatase activity
SMA_RS05515	COG0110	maltose O-acetyltransferase activity
SMA_RS05550	COG2801	Transposase and inactivated derivatives
SMA_RS05560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMA_RS05560	COG2190	(PTS) system
SMA_RS05560	COG1263	PTS System
SMA_RS05575	COG1177	transmembrane transport
SMA_RS05580	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMA_RS05590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMA_RS05615	COG0285	dihydrofolate synthase activity
SMA_RS05620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMA_RS05625	COG1126	abc transporter atp-binding protein
SMA_RS05630	COG4215	(ABC) transporter
SMA_RS05645	COG2962	Rard protein
SMA_RS05660	COG0726	polysaccharide deacetylase
SMA_RS05680	COG4974	Belongs to the 'phage' integrase family
SMA_RS05720	COG1105	Belongs to the carbohydrate kinase PfkB family
SMA_RS05725	COG0698	ribose 5-phosphate isomerase
SMA_RS05730	COG0698	ribose 5-phosphate isomerase
SMA_RS05735	COG1940	carbohydrate kinase activity
SMA_RS05755	COG4974	Belongs to the 'phage' integrase family
SMA_RS05800	COG2040	homocysteine
SMA_RS05805	COG0833	amino acid
SMA_RS05825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMA_RS05835	COG3425	synthase
SMA_RS05850	COG1272	protein, Hemolysin III
SMA_RS05855	COG1304	FMN binding
SMA_RS05870	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMA_RS05875	COG0435	Glutathione S-transferase
SMA_RS05880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMA_RS05885	COG1126	abc transporter atp-binding protein
SMA_RS05890	COG0765	amino acid transport
SMA_RS05895	COG0765	amino acid transport
SMA_RS05900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMA_RS05910	COG0583	DNA-binding transcription factor activity
SMA_RS05915	COG0656	L-ascorbic acid biosynthetic process
SMA_RS05945	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMA_RS05965	COG0745	RESPONSE REGULATOR receiver
SMA_RS05970	COG2357	RelA SpoT domain protein
SMA_RS06005	COG1132	(ABC) transporter
SMA_RS06020	COG0242	peptide deformylase activity
SMA_RS06030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMA_RS06040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMA_RS06045	COG0602	queuosine metabolic process
SMA_RS06050	COG0720	synthase
SMA_RS06055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMA_RS06060	COG1132	(ABC) transporter
SMA_RS06070	COG0488	(ABC) transporter
SMA_RS06075	COG0617	tRNA 3'-terminal CCA addition
SMA_RS06095	COG3942	CHAP domain
SMA_RS06095	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMA_RS06105	COG0646	methionine synthase
SMA_RS06105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMA_RS06110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMA_RS06115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMA_RS06115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMA_RS06115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMA_RS06120	COG1105	Belongs to the carbohydrate kinase PfkB family
SMA_RS06125	COG1349	DNA-binding transcription factor activity
SMA_RS06130	COG0492	ferredoxin-NADP+ reductase activity
SMA_RS06135	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMA_RS06140	COG0336	Belongs to the RNA methyltransferase TrmD family
SMA_RS06145	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMA_RS06160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMA_RS06165	COG1837	Belongs to the UPF0109 family
SMA_RS06195	COG0577	efflux transmembrane transporter activity
SMA_RS06200	COG1136	(ABC) transporter
SMA_RS06215	COG0505	Belongs to the CarA family
SMA_RS06220	COG0540	Belongs to the ATCase OTCase family
SMA_RS06235	COG0564	pseudouridine synthase activity
SMA_RS06245	COG0583	DNA-binding transcription factor activity
SMA_RS06250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMA_RS06275	COG0301	tRNA thio-modification
SMA_RS06280	COG1104	cysteine desulfurase activity
SMA_RS06290	COG0285	dihydrofolate synthase activity
SMA_RS06305	COG0287	Prephenate dehydrogenase
SMA_RS06315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMA_RS06320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMA_RS06330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMA_RS06345	COG1368	sulfuric ester hydrolase activity
SMA_RS06350	COG3344	reverse transcriptase
SMA_RS06355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMA_RS06360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMA_RS06365	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMA_RS06385	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMA_RS06400	COG3942	CHAP domain
SMA_RS06405	COG0463	Glycosyl transferase, family 2
SMA_RS06420	COG1368	sulfuric ester hydrolase activity
SMA_RS06425	COG1442	glycosyl transferase family 8
SMA_RS06425	COG1216	Glycosyl transferase, family 2
SMA_RS06430	COG1216	Glycosyl transferase, family 2
SMA_RS06450	COG1216	Glycosyl transferase, family 2
SMA_RS06480	COG1442	glycosyl transferase family 8
SMA_RS06480	COG1216	Glycosyl transferase, family 2
SMA_RS06490	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMA_RS06495	COG2151	metal-sulfur cluster biosynthetic enzyme
SMA_RS06500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMA_RS06505	COG0358	DNA primase activity
SMA_RS06510	COG1970	mechanosensitive ion channel activity
SMA_RS06525	COG2801	Transposase and inactivated derivatives
SMA_RS06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMA_RS06535	COG0436	Aminotransferase
SMA_RS06540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMA_RS06550	COG0058	SHG alpha-glucan phosphorylase activity
SMA_RS06555	COG1640	4-alpha-glucanotransferase
SMA_RS06560	COG1609	Transcriptional regulator
SMA_RS06570	COG1175	transmembrane transport
SMA_RS06575	COG3833	ABC-type maltose transport systems, permease component
SMA_RS06580	COG2816	NAD+ diphosphatase activity
SMA_RS06585	COG0556	nucleotide-excision repair
SMA_RS06590	COG0765	amino acid transport
SMA_RS06595	COG1126	abc transporter atp-binding protein
SMA_RS06615	COG1187	pseudouridine synthase activity
SMA_RS06620	COG4166	transmembrane transport
SMA_RS06635	COG2801	Transposase and inactivated derivatives
SMA_RS06650	COG2217	Heavy metal translocating P-type atpase
SMA_RS06655	COG1597	lipid kinase activity
SMA_RS06675	COG4619	ABC transporter
SMA_RS06680	COG0390	transport system, permease component
SMA_RS06690	COG2801	Transposase and inactivated derivatives
SMA_RS06730	COG1396	sequence-specific DNA binding
SMA_RS06770	COG3328	transposase activity
SMA_RS06780	COG2205	protein histidine kinase activity
SMA_RS06785	COG3843	relaxase mobilization nuclease domain protein
SMA_RS06800	COG4991	sh3 domain protein
SMA_RS06800	COG0515	serine threonine protein kinase
SMA_RS06800	COG3064	Membrane
SMA_RS06810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMA_RS06860	COG2197	response regulator
SMA_RS07005	COG0270	DNA (cytosine-5-)-methyltransferase activity
SMA_RS07020	COG1316	TRANSCRIPTIONal
SMA_RS07025	COG0077	Prephenate dehydratase
SMA_RS07030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMA_RS07035	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMA_RS07040	COG0481	GTPase activity
SMA_RS07055	COG1518	maintenance of DNA repeat elements
SMA_RS07080	COG0647	UMP catabolic process
SMA_RS07095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMA_RS07105	COG2801	Transposase and inactivated derivatives
SMA_RS07110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMA_RS07120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SMA_RS07125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMA_RS07130	COG3442	glutamine amidotransferase
SMA_RS07140	COG0148	phosphopyruvate hydratase activity
SMA_RS07160	COG1523	belongs to the glycosyl hydrolase 13 family
SMA_RS07180	COG0107	imidazoleglycerol-phosphate synthase activity
SMA_RS07190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMA_RS07200	COG0560	Phosphoserine phosphatase
SMA_RS07205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMA_RS07215	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMA_RS07235	COG0187	DNA topoisomerase II activity
SMA_RS07245	COG0772	Belongs to the SEDS family
SMA_RS07260	COG0038	chloride channel
SMA_RS07265	COG0287	Prephenate dehydrogenase
SMA_RS07265	COG1605	Chorismate mutase
SMA_RS07280	COG0716	FMN binding
SMA_RS07290	COG0017	Asparaginyl-tRNA synthetase
SMA_RS07300	COG0436	Aminotransferase
SMA_RS07310	COG1199	ATP-dependent helicase activity
SMA_RS07310	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMA_RS07345	COG2177	Part of the ABC transporter FtsEX involved in
SMA_RS07350	COG2884	Cell division ATP-binding protein ftsE
SMA_RS07355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SMA_RS07385	COG1078	dGTPase activity
SMA_RS07415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMA_RS07435	COG0772	Belongs to the SEDS family
SMA_RS07445	COG1164	Oligoendopeptidase f
SMA_RS07450	COG0386	Belongs to the glutathione peroxidase family
SMA_RS07470	COG0588	phosphoglycerate mutase activity
SMA_RS07485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMA_RS07505	COG1268	BioY protein
SMA_RS07510	COG4443	Transcriptional Coactivator p15 (PC4)
SMA_RS07525	COG0826	peptidase U32
SMA_RS07570	COG2183	response to ionizing radiation
SMA_RS07580	COG0701	Predicted permease
SMA_RS07585	COG3689	TIGRFAM TIGR03943 family protein
SMA_RS07600	COG0552	protein localization to endoplasmic reticulum
SMA_RS07605	COG0561	phosphatase activity
SMA_RS07610	COG0561	phosphatase activity
SMA_RS07620	COG0494	nUDIX hydrolase
SMA_RS07625	COG1196	nuclear chromosome segregation
SMA_RS07635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMA_RS07640	COG5002	protein histidine kinase activity
SMA_RS07645	COG0745	RESPONSE REGULATOR receiver
SMA_RS07650	COG1126	abc transporter atp-binding protein
SMA_RS07655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMA_RS07660	COG0765	amino acid transport
SMA_RS07665	COG0765	amino acid transport
SMA_RS07685	COG5002	protein histidine kinase activity
SMA_RS07700	COG0745	RESPONSE REGULATOR receiver
SMA_RS07715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMA_RS07720	COG0438	transferase activity, transferring glycosyl groups
SMA_RS07730	COG1609	Transcriptional regulator
SMA_RS07735	COG0006	proline dipeptidase activity
SMA_RS07755	COG0778	Nitroreductase
SMA_RS07785	COG0557	exoribonuclease II activity
SMA_RS07805	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMA_RS07815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMA_RS07820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMA_RS07835	COG1702	phosphate starvation-inducible protein PhoH
SMA_RS07845	COG4479	Belongs to the UPF0346 family
SMA_RS07855	COG2996	Protein conserved in bacteria
SMA_RS07890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SMA_RS07915	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMA_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
SMA_RS07950	COG1695	Transcriptional regulator
SMA_RS07980	COG0640	Transcriptional regulator
SMA_RS07985	COG0708	Exodeoxyribonuclease III
SMA_RS08000	COG1393	Belongs to the ArsC family
SMA_RS08005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMA_RS08015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMA_RS08035	COG0347	Belongs to the P(II) protein family
SMA_RS08040	COG0004	ammonium transporteR
SMA_RS08055	COG1774	PSP1 C-terminal conserved region
SMA_RS08060	COG0470	DNA polymerase III
SMA_RS08070	COG1227	inorganic diphosphatase activity
SMA_RS08070	COG0517	IMP dehydrogenase activity
SMA_RS08120	COG0583	DNA-binding transcription factor activity
SMA_RS08125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMA_RS08130	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMA_RS08135	COG0626	cystathionine gamma-synthase activity
SMA_RS08140	COG2244	polysaccharide biosynthetic process
SMA_RS08145	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMA_RS08150	COG1120	ATPase activity
SMA_RS08155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMA_RS08160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMA_RS08165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMA_RS08205	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMA_RS08210	COG1253	flavin adenine dinucleotide binding
SMA_RS08215	COG1119	ATPase activity
SMA_RS08220	COG0025	NhaP-type Na H and K H
SMA_RS08230	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SMA_RS08235	COG1242	4 iron, 4 sulfur cluster binding
SMA_RS08240	COG0671	phosphoesterase, PA-phosphatase related
SMA_RS08250	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SMA_RS08275	COG0531	amino acid
SMA_RS08280	COG0569	domain protein
SMA_RS08285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMA_RS08290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMA_RS08295	COG1187	pseudouridine synthase activity
SMA_RS08310	COG0582	viral genome integration into host DNA
SMA_RS08330	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMA_RS08335	COG3763	UPF0154 protein
SMA_RS08340	COG2826	transposase and inactivated derivatives, IS30 family
SMA_RS08360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMA_RS08365	COG1254	Belongs to the acylphosphatase family
SMA_RS08375	COG2826	transposase and inactivated derivatives, IS30 family
SMA_RS08385	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMA_RS08400	COG4372	Transposase
SMA_RS08450	COG1484	DNA-dependent DNA replication
SMA_RS08465	COG5002	protein histidine kinase activity
SMA_RS08470	COG0745	RESPONSE REGULATOR receiver
SMA_RS08480	COG0501	Belongs to the peptidase M48B family
SMA_RS08485	COG1704	LemA family
SMA_RS08495	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMA_RS08500	COG0569	domain protein
SMA_RS08510	COG1122	ATPase activity
SMA_RS08530	COG1114	Component of the transport system for branched-chain amino acids
SMA_RS08535	COG2910	NAD(P)H-binding
SMA_RS08540	COG1959	2 iron, 2 sulfur cluster binding
SMA_RS08565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMA_RS08570	COG1473	amidohydrolase
SMA_RS08575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMA_RS08580	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMA_RS08585	COG0217	transcriptional regulatory protein
SMA_RS08595	COG0789	Transcriptional regulator
SMA_RS08600	COG1323	Belongs to the UPF0348 family
SMA_RS08615	COG2226	methyltransferase
SMA_RS08620	COG0799	negative regulation of ribosome biogenesis
SMA_RS08625	COG1713	HD superfamily hydrolase involved in NAD metabolism
SMA_RS08630	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMA_RS08635	COG1534	Rna-binding protein
SMA_RS08640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMA_RS08645	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SMA_RS08650	COG2814	Major facilitator Superfamily
SMA_RS08655	COG1846	Transcriptional regulator
SMA_RS08660	COG0697	spore germination
SMA_RS08670	COG0154	amidase activity
SMA_RS08675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMA_RS08685	COG1335	isochorismatase
SMA_RS08690	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SMA_RS08700	COG0436	Aminotransferase
SMA_RS08710	COG0589	response to stress
SMA_RS08715	COG0561	phosphatase activity
SMA_RS08720	COG0252	asparaginase activity
SMA_RS08725	COG3655	Transcriptional regulator
SMA_RS08745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMA_RS08760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMA_RS08765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMA_RS08775	COG1940	carbohydrate kinase activity
SMA_RS08780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMA_RS08780	COG2190	(PTS) system
SMA_RS08780	COG1263	PTS System
SMA_RS08785	COG1621	beta-fructofuranosidase activity
SMA_RS08790	COG1609	Transcriptional regulator
SMA_RS08795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMA_RS08805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMA_RS08810	COG2131	deaminase
SMA_RS08815	COG0006	proline dipeptidase activity
SMA_RS08825	COG0598	Magnesium transport protein CorA
SMA_RS08840	COG3655	Transcriptional regulator
SMA_RS08850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMA_RS08855	COG0629	single-stranded DNA binding
SMA_RS08870	COG2963	transposase activity
SMA_RS08895	COG1194	a g-specific adenine glycosylase
SMA_RS08930	COG1063	alcohol dehydrogenase
SMA_RS08935	COG3118	belongs to the thioredoxin family
SMA_RS08940	COG0157	Belongs to the NadC ModD family
SMA_RS08975	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMA_RS08980	COG0681	Belongs to the peptidase S26 family
SMA_RS08985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMA_RS09000	COG1882	Formate acetyltransferase
SMA_RS09015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMA_RS09030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SMA_RS09040	COG5002	protein histidine kinase activity
SMA_RS09050	COG0704	Plays a role in the regulation of phosphate uptake
SMA_RS09055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMA_RS09060	COG0581	inorganic phosphate transmembrane transporter activity
SMA_RS09065	COG0573	inorganic phosphate transmembrane transporter activity
SMA_RS09080	COG0789	Transcriptional regulator
SMA_RS09095	COG2081	HI0933 family
SMA_RS09115	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SMA_RS09130	COG1214	PFAM Peptidase M22, glycoprotease
SMA_RS09135	COG5503	Protein of unknown function (DUF1447)
SMA_RS09150	COG0493	'glutamate synthase
SMA_RS09155	COG0067	glutamate synthase
SMA_RS09155	COG0069	glutamate synthase activity
SMA_RS09155	COG0070	glutamate synthase
SMA_RS09160	COG0174	glutamine synthetase
SMA_RS09165	COG0789	Transcriptional regulator
SMA_RS09175	COG0126	phosphoglycerate kinase activity
SMA_RS09200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMA_RS09280	COG2801	Transposase and inactivated derivatives
SMA_RS09285	COG2963	transposase activity
SMA_RS09295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SMA_RS09335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SMA_RS09355	COG0084	hydrolase, TatD family'
SMA_RS09365	COG2217	Heavy metal translocating P-type atpase
SMA_RS09385	COG0681	Belongs to the peptidase S26 family
SMA_RS09415	COG0281	malic enzyme
SMA_RS09420	COG0583	DNA-binding transcription factor activity
SMA_RS09425	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SMA_RS09430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMA_RS09435	COG1696	Membrane protein involved in D-alanine export
SMA_RS09455	COG1394	ATPase activity, coupled to movement of substances
SMA_RS09460	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
SMA_RS09485	COG3177	Filamentation induced by cAMP protein fic
SMA_RS09490	COG2801	Transposase and inactivated derivatives
SMA_RS09500	COG2217	Heavy metal translocating P-type atpase
SMA_RS09505	COG2217	Heavy metal translocating P-type atpase
SMA_RS09510	COG2217	Heavy metal translocating P-type atpase
SMA_RS09520	COG2217	Heavy metal translocating P-type atpase
SMA_RS09525	COG2217	Heavy metal translocating P-type atpase
SMA_RS09540	COG0798	PFAM Bile acid sodium symporter
SMA_RS09545	COG2801	Transposase and inactivated derivatives
SMA_RS09550	COG2963	transposase activity
SMA_RS09555	COG3843	relaxase mobilization nuclease domain protein
SMA_RS09570	COG3344	reverse transcriptase
SMA_RS09605	COG2801	Transposase and inactivated derivatives
SMA_RS09640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SMA_RS09650	COG3843	relaxase mobilization nuclease domain protein
SMA_RS09675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMA_RS09675	COG0551	DNA topoisomerase type I activity
SMA_RS09705	COG0629	single-stranded DNA binding
SMA_RS09795	COG1131	(ABC) transporter
SMA_RS09810	COG0594	ribonuclease P activity
SMA_RS09825	COG2807	transmembrane transport
SMA_RS09830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMA_RS09870	COG0756	dUTP diphosphatase activity
SMA_RS09890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMA_RS09895	COG0457	Tetratricopeptide repeat
SMA_RS09895	COG0705	Rhomboid family
SMA_RS09900	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMA_RS09910	COG2171	N-acyltransferase activity
SMA_RS09935	COG0166	Belongs to the GPI family
SMA_RS09945	COG1234	tRNA 3'-trailer cleavage
SMA_RS09950	COG1268	BioY protein
SMA_RS09955	COG0343	queuine tRNA-ribosyltransferase activity
SMA_RS09970	COG3479	Phenolic acid decarboxylase
SMA_RS09980	COG1832	CoA-binding protein
SMA_RS09985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMA_RS09985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMA_RS10010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMA_RS10015	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMA_RS10015	COG2918	glutathione biosynthetic process
SMA_RS10030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMA_RS10035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMA_RS10040	COG0542	response to heat
SMA_RS10045	COG4463	regulation of RNA biosynthetic process
SMA_RS10060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMA_RS10075	COG1619	proteins homologs of microcin C7 resistance protein MccF
SMA_RS10085	COG3590	peptidase
SMA_RS10095	COG0366	Alpha amylase catalytic
SMA_RS10105	COG2255	four-way junction helicase activity
SMA_RS10110	COG0602	queuosine metabolic process
SMA_RS10120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMA_RS10120	COG1328	CTP reductase activity
SMA_RS10140	COG4472	Bacterial protein of unknown function (DUF965)
SMA_RS10145	COG1393	Belongs to the ArsC family
SMA_RS10155	COG1546	Belongs to the CinA family
SMA_RS10155	COG1058	Belongs to the CinA family
SMA_RS10180	COG0632	four-way junction helicase activity
SMA_RS10220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMA_RS10225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMA_RS10240	COG2151	metal-sulfur cluster biosynthetic enzyme
SMA_RS10245	COG0129	dihydroxy-acid dehydratase activity
SMA_RS10255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMA_RS10260	COG2261	transglycosylase associated protein
SMA_RS10310	COG3759	membrane
SMA_RS10315	COG1511	domain protein
SMA_RS10320	COG1309	transcriptional regulator
SMA_RS10335	COG4466	Protein conserved in bacteria
SMA_RS10340	COG0305	Participates in initiation and elongation during chromosome replication
SMA_RS10355	COG0445	tRNA wobble uridine modification
SMA_RS10365	COG1760	l-serine dehydratase
SMA_RS10370	COG1760	l-serine dehydratase
SMA_RS10375	COG0546	phosphoglycolate phosphatase activity
SMA_RS10380	COG0741	lytic transglycosylase activity
SMA_RS10395	COG1122	ATPase activity
SMA_RS10400	COG1122	ATPase activity
SMA_RS10405	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMA_RS10415	COG0612	Peptidase, M16
SMA_RS10420	COG0612	Peptidase, M16
SMA_RS10475	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMA_RS10485	COG0517	IMP dehydrogenase activity
SMA_RS10485	COG0516	GMP reductase activity
SMA_RS10495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMA_RS10500	COG0488	(ABC) transporter
SMA_RS10535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMA_RS10540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMA_RS10545	COG1475	DNA binding
SMA_RS10635	COG0582	viral genome integration into host DNA