locus-tag	class	description
A4H00_RS00010	COG2855	membrane
A4H00_RS00020	COG0560	Phosphoserine phosphatase
A4H00_RS00025	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A4H00_RS00030	COG0187	DNA topoisomerase II activity
A4H00_RS00035	COG0693	protein deglycase activity
A4H00_RS00040	COG0772	Belongs to the SEDS family
A4H00_RS00045	COG0254	rRNA binding
A4H00_RS00055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4H00_RS00060	COG0716	FMN binding
A4H00_RS00065	COG0038	chloride channel
A4H00_RS00080	COG0335	large ribosomal subunit rRNA binding
A4H00_RS00090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4H00_RS00110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4H00_RS00115	COG4122	O-methyltransferase activity
A4H00_RS00130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4H00_RS00130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4H00_RS00135	COG0708	Exodeoxyribonuclease III
A4H00_RS00150	COG2723	6-phospho-beta-galactosidase activity
A4H00_RS00160	COG1263	PTS System
A4H00_RS00160	COG2190	(PTS) system
A4H00_RS00160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4H00_RS00175	COG1393	Belongs to the ArsC family
A4H00_RS00190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4H00_RS00200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4H00_RS00210	COG4467	Involved in initiation control of chromosome replication
A4H00_RS00215	COG0470	DNA polymerase III
A4H00_RS00225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4H00_RS00230	COG0517	IMP dehydrogenase activity
A4H00_RS00230	COG1125	glycine betaine transport
A4H00_RS00240	COG1136	(ABC) transporter
A4H00_RS00240	COG0577	efflux transmembrane transporter activity
A4H00_RS00270	COG0559	Belongs to the binding-protein-dependent transport system permease family
A4H00_RS00275	COG0683	leucine binding
A4H00_RS00295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4H00_RS00300	COG0366	Alpha amylase catalytic
A4H00_RS00310	COG0366	Alpha amylase catalytic
A4H00_RS00315	COG0395	ABC-type sugar transport system, permease component
A4H00_RS00320	COG1175	transmembrane transport
A4H00_RS00325	COG1653	transport
A4H00_RS00335	COG2207	Transcriptional regulator
A4H00_RS00340	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A4H00_RS00340	COG3583	domain protein
A4H00_RS00340	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
A4H00_RS00340	COG3583	domain protein
A4H00_RS00355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4H00_RS00360	COG0626	cystathionine gamma-synthase activity
A4H00_RS00365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4H00_RS00370	COG1187	pseudouridine synthase activity
A4H00_RS00375	COG0363	glucosamine-6-phosphate deaminase activity
A4H00_RS00505	COG0582	viral genome integration into host DNA
A4H00_RS00510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4H00_RS00515	COG0436	Aminotransferase
A4H00_RS00520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4H00_RS00525	COG1466	dna polymerase III delta subunit
A4H00_RS00550	COG0318	PFAM AMP-dependent synthetase and ligase
A4H00_RS00555	COG2333	competence protein COMEC
A4H00_RS00555	COG0658	competence protein
A4H00_RS00560	COG1596	polysaccharide export
A4H00_RS00560	COG1555	photosystem II stabilization
A4H00_RS00565	COG0204	Acyl-transferase
A4H00_RS00570	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4H00_RS00605	COG0577	efflux transmembrane transporter activity
A4H00_RS00610	COG1136	(ABC) transporter
A4H00_RS00615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4H00_RS00625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4H00_RS00630	COG1268	BioY protein
A4H00_RS00635	COG4443	Transcriptional Coactivator p15 (PC4)
A4H00_RS00645	COG0826	peptidase U32
A4H00_RS00665	COG3716	PTS system mannose fructose sorbose family IID component
A4H00_RS00670	COG3715	PTS system
A4H00_RS00675	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4H00_RS00690	COG1070	Carbohydrate kinase
A4H00_RS00695	COG2115	Belongs to the xylose isomerase family
A4H00_RS00700	COG1846	Transcriptional regulator
A4H00_RS00700	COG1940	carbohydrate kinase activity
A4H00_RS00715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4H00_RS00720	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A4H00_RS00735	COG3091	SprT-like family
A4H00_RS00740	COG2183	response to ionizing radiation
A4H00_RS00745	COG4708	membrane
A4H00_RS00770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4H00_RS00775	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4H00_RS00790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4H00_RS00800	COG0066	3-isopropylmalate dehydratase activity
A4H00_RS00840	COG0726	polysaccharide deacetylase
A4H00_RS00860	COG3425	synthase
A4H00_RS00880	COG0776	regulation of translation
A4H00_RS00890	COG2755	lipolytic protein G-D-S-L family
A4H00_RS00895	COG1307	EDD domain protein, DegV family
A4H00_RS00905	COG0497	DNA recombination
A4H00_RS00910	COG1438	arginine binding
A4H00_RS00915	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A4H00_RS00925	COG1722	exodeoxyribonuclease VII activity
A4H00_RS00930	COG1570	exodeoxyribonuclease VII activity
A4H00_RS00935	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4H00_RS00950	COG3579	cysteine-type endopeptidase activity
A4H00_RS00965	COG4470	Protein conserved in bacteria
A4H00_RS00975	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4H00_RS00980	COG0742	ribosomal rna small subunit methyltransferase
A4H00_RS00990	COG4483	Protein conserved in bacteria
A4H00_RS01000	COG2197	response regulator
A4H00_RS01005	COG4585	Histidine kinase
A4H00_RS01010	COG0842	Transport permease protein
A4H00_RS01015	COG1131	(ABC) transporter
A4H00_RS01030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4H00_RS01040	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A4H00_RS01040	COG2755	lipolytic protein G-D-S-L family
A4H00_RS01055	COG0671	phosphoesterase, PA-phosphatase related
A4H00_RS01060	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A4H00_RS01070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4H00_RS01075	COG1187	pseudouridine synthase activity
A4H00_RS01080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4H00_RS01085	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4H00_RS01090	COG0582	viral genome integration into host DNA
A4H00_RS01115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4H00_RS01120	COG3763	UPF0154 protein
A4H00_RS01140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4H00_RS01145	COG1254	Belongs to the acylphosphatase family
A4H00_RS01155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4H00_RS01160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4H00_RS01170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4H00_RS01180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4H00_RS01200	COG1160	GTP binding
A4H00_RS01210	COG1484	DNA-dependent DNA replication
A4H00_RS01220	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4H00_RS01225	COG0628	permease
A4H00_RS01235	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4H00_RS01245	COG0492	ferredoxin-NADP+ reductase activity
A4H00_RS01255	COG0513	Belongs to the DEAD box helicase family
A4H00_RS01260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4H00_RS01265	COG0768	penicillin binding
A4H00_RS01275	COG0275	rRNA processing
A4H00_RS01305	COG1477	protein flavinylation
A4H00_RS01310	COG4939	FMN-binding domain protein
A4H00_RS01315	COG0142	geranyltranstransferase activity
A4H00_RS01320	COG1252	NADH dehydrogenase
A4H00_RS01330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4H00_RS01335	COG0569	domain protein
A4H00_RS01340	COG0534	Mate efflux family protein
A4H00_RS01345	COG4224	UPF0291 protein
A4H00_RS01350	COG0751	glycine-tRNA ligase activity
A4H00_RS01360	COG0656	L-ascorbic acid biosynthetic process
A4H00_RS01370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4H00_RS01375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4H00_RS01380	COG1464	Belongs to the NlpA lipoprotein family
A4H00_RS01395	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4H00_RS01400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4H00_RS01410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4H00_RS01435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4H00_RS01445	COG4473	ABC transporter
A4H00_RS01450	COG1131	(ABC) transporter
A4H00_RS01455	COG0537	adenosine 5'-monophosphoramidase activity
A4H00_RS01465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4H00_RS01480	COG2801	Transposase and inactivated derivatives
A4H00_RS01580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4H00_RS01585	COG0719	Fe-S assembly protein
A4H00_RS01595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4H00_RS01600	COG4862	establishment of competence for transformation
A4H00_RS01605	COG1968	undecaprenyl-diphosphatase activity
A4H00_RS01610	COG0765	amino acid transport
A4H00_RS01615	COG1126	abc transporter atp-binding protein
A4H00_RS01630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4H00_RS01635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4H00_RS01640	COG0440	acetolactate synthase activity
A4H00_RS01645	COG0028	Belongs to the TPP enzyme family
A4H00_RS01650	COG0129	dihydroxy-acid dehydratase activity
A4H00_RS01665	COG2801	Transposase and inactivated derivatives
A4H00_RS01675	COG2151	metal-sulfur cluster biosynthetic enzyme
A4H00_RS01680	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4H00_RS01685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4H00_RS01695	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A4H00_RS01700	COG0195	Participates in both transcription termination and antitermination
A4H00_RS01705	COG0779	Required for maturation of 30S ribosomal subunits
A4H00_RS01730	COG1316	TRANSCRIPTIONal
A4H00_RS01740	COG0802	atpase or kinase
A4H00_RS01745	COG2252	PERMEase
A4H00_RS01750	COG0561	phosphatase activity
A4H00_RS01760	COG3715	PTS system
A4H00_RS01765	COG3716	PTS system mannose fructose sorbose family IID component
A4H00_RS01790	COG0825	malonyl-CoA metabolic process
A4H00_RS01800	COG0439	Biotin carboxylase
A4H00_RS01805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4H00_RS01815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4H00_RS01820	COG1028	Short-chain dehydrogenase reductase Sdr
A4H00_RS01825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4H00_RS01840	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4H00_RS01850	COG0527	aspartate kinase activity
A4H00_RS01855	COG3684	Belongs to the aldolase LacD family
A4H00_RS01865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4H00_RS01870	COG0736	holo-[acyl-carrier-protein] synthase activity
A4H00_RS01880	COG1482	cell wall glycoprotein biosynthetic process
A4H00_RS01885	COG1940	carbohydrate kinase activity
A4H00_RS01890	COG1263	PTS System
A4H00_RS01890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4H00_RS01890	COG2190	(PTS) system
A4H00_RS01895	COG1621	beta-fructofuranosidase activity
A4H00_RS01900	COG1609	Transcriptional regulator
A4H00_RS01905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4H00_RS01920	COG0006	proline dipeptidase activity
A4H00_RS01935	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4H00_RS01940	COG0598	Magnesium transport protein CorA
A4H00_RS01950	COG1929	Belongs to the glycerate kinase type-1 family
A4H00_RS01975	COG2801	Transposase and inactivated derivatives
A4H00_RS02025	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4H00_RS02035	COG1132	(ABC) transporter
A4H00_RS02040	COG4475	Protein of unknown function (DUF436)
A4H00_RS02050	COG0351	phosphomethylpyrimidine kinase
A4H00_RS02075	COG0765	amino acid transport
A4H00_RS02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4H00_RS02110	COG0484	heat shock protein binding
A4H00_RS02120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4H00_RS02125	COG1420	regulation of RNA biosynthetic process
A4H00_RS02150	COG0588	phosphoglycerate mutase activity
A4H00_RS02160	COG3830	Belongs to the UPF0237 family
A4H00_RS02170	COG3804	dihydrodipicolinate reductase
A4H00_RS02175	COG0789	Transcriptional regulator
A4H00_RS02180	COG1304	FMN binding
A4H00_RS02195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4H00_RS02200	COG2918	glutathione biosynthetic process
A4H00_RS02200	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4H00_RS02205	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A4H00_RS02210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4H00_RS02215	COG0542	response to heat
A4H00_RS02230	COG1724	mRNA binding
A4H00_RS02335	COG4974	Belongs to the 'phage' integrase family
A4H00_RS02350	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4H00_RS02370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4H00_RS02405	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A4H00_RS02410	COG0215	cysteine-tRNA ligase activity
A4H00_RS02420	COG1045	serine acetyltransferase
A4H00_RS02430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4H00_RS02470	COG1187	pseudouridine synthase activity
A4H00_RS02475	COG0242	peptide deformylase activity
A4H00_RS02495	COG1098	S1 RNA binding domain
A4H00_RS02515	COG4585	Histidine kinase
A4H00_RS02525	COG0515	serine threonine protein kinase
A4H00_RS02525	COG2815	serine threonine protein kinase
A4H00_RS02530	COG0631	protein serine/threonine phosphatase activity
A4H00_RS02535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4H00_RS02535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4H00_RS02540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4H00_RS02545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4H00_RS02550	COG1758	RNA polymerase activity
A4H00_RS02555	COG0194	GDP metabolic process
A4H00_RS02560	COG1418	mRNA catabolic process
A4H00_RS02565	COG1854	S-ribosylhomocysteine lyase activity
A4H00_RS02575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4H00_RS02585	COG0116	Belongs to the methyltransferase superfamily
A4H00_RS02595	COG3599	regulation of cell shape
A4H00_RS02600	COG4474	Belongs to the UPF0398 family
A4H00_RS02605	COG3331	DNA recombination
A4H00_RS02610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4H00_RS02615	COG0357	Ribosomal RNA small subunit methyltransferase G
A4H00_RS02625	COG1122	ATPase activity
A4H00_RS02630	COG0436	Aminotransferase
A4H00_RS02640	COG0251	oxidation-reduction process
A4H00_RS02645	COG2964	Protein conserved in bacteria
A4H00_RS02650	COG1054	Belongs to the UPF0176 family
A4H00_RS02655	COG4720	Psort location CytoplasmicMembrane, score
A4H00_RS02665	COG0095	Lipoate-protein ligase
A4H00_RS02675	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4H00_RS02680	COG0022	dehydrogenase e1 component
A4H00_RS02680	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4H00_RS02685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4H00_RS02690	COG2860	membrane
A4H00_RS02695	COG1129	ABC transporter
A4H00_RS02710	COG1132	(ABC) transporter
A4H00_RS02715	COG4988	ABC transporter
A4H00_RS02725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4H00_RS02730	COG0629	single-stranded DNA binding
A4H00_RS02745	COG1621	beta-fructofuranosidase activity
A4H00_RS02755	COG0395	ABC-type sugar transport system, permease component
A4H00_RS02760	COG4209	transmembrane transport
A4H00_RS02765	COG1609	Transcriptional regulator
A4H00_RS02770	COG1461	Dihydroxyacetone kinase
A4H00_RS02780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4H00_RS02795	COG0191	fructose-bisphosphate aldolase activity
A4H00_RS02810	COG0504	CTP synthase activity
A4H00_RS02815	COG3343	RNA polymerase activity
A4H00_RS02820	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4H00_RS02825	COG2826	transposase and inactivated derivatives, IS30 family
A4H00_RS02845	COG3250	beta-galactosidase activity
A4H00_RS02870	COG2826	transposase and inactivated derivatives, IS30 family
A4H00_RS02905	COG0492	ferredoxin-NADP+ reductase activity
A4H00_RS02910	COG0564	pseudouridine synthase activity
A4H00_RS02930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4H00_RS02935	COG3481	metal-dependent phosphohydrolase, HD sub domain
A4H00_RS02945	COG1564	THIamine pyrophosphokinase
A4H00_RS02955	COG1162	GTPase activity
A4H00_RS02960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4H00_RS02975	COG0084	hydrolase, TatD family'
A4H00_RS02980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4H00_RS02995	COG0594	ribonuclease P activity
A4H00_RS03070	COG0756	dUTP diphosphatase activity
A4H00_RS03080	COG1132	(ABC) transporter
A4H00_RS03085	COG1132	(ABC) transporter
A4H00_RS03090	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4H00_RS03095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4H00_RS03110	COG0705	Rhomboid family
A4H00_RS03110	COG0457	Tetratricopeptide repeat
A4H00_RS03115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4H00_RS03120	COG1473	amidohydrolase
A4H00_RS03140	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4H00_RS03160	COG3623	hexulose-6-phosphate isomerase
A4H00_RS03180	COG3037	sugar-specific permease SgaT UlaA
A4H00_RS03215	COG1396	sequence-specific DNA binding
A4H00_RS03230	COG3590	peptidase
A4H00_RS03275	COG1490	D-aminoacyl-tRNA deacylase activity
A4H00_RS03290	COG1132	(ABC) transporter
A4H00_RS03305	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4H00_RS03310	COG2264	protein methyltransferase activity
A4H00_RS03345	COG1328	CTP reductase activity
A4H00_RS03380	COG0459	protein refolding
A4H00_RS03385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4H00_RS03395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4H00_RS03400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4H00_RS03410	COG1363	Peptidase, m42
A4H00_RS03450	COG4537	Required for transformation and DNA binding
A4H00_RS03455	COG1459	type II secretion system
A4H00_RS03460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4H00_RS03465	COG3906	Belongs to the UPF0473 family
A4H00_RS03470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4H00_RS03475	COG4472	Bacterial protein of unknown function (DUF965)
A4H00_RS03480	COG1393	Belongs to the ArsC family
A4H00_RS03505	COG2818	Glycosylase
A4H00_RS03510	COG0632	four-way junction helicase activity
A4H00_RS03515	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4H00_RS03545	COG1438	arginine binding
A4H00_RS03550	COG0018	arginyl-trna synthetase
A4H00_RS03570	COG1132	(ABC) transporter
A4H00_RS03590	COG1640	4-alpha-glucanotransferase
A4H00_RS03595	COG2182	Extracellular solute-binding protein
A4H00_RS03600	COG1175	transmembrane transport
A4H00_RS03605	COG3833	ABC-type maltose transport systems, permease component
A4H00_RS03610	COG5521	maltodextrose utilization protein MalA
A4H00_RS03615	COG1609	Transcriptional regulator
A4H00_RS03620	COG1523	belongs to the glycosyl hydrolase 13 family
A4H00_RS03635	COG1780	Probably involved in ribonucleotide reductase function
A4H00_RS03640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4H00_RS03645	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4H00_RS03650	COG4989	oxidoreductase activity
A4H00_RS03655	COG1216	Glycosyl transferase, family 2
A4H00_RS03660	COG1472	Belongs to the glycosyl hydrolase 3 family
A4H00_RS03695	COG3177	Filamentation induced by cAMP protein fic
A4H00_RS03715	COG1053	succinate dehydrogenase
A4H00_RS03725	COG0285	dihydrofolate synthase activity
A4H00_RS03745	COG0305	Participates in initiation and elongation during chromosome replication
A4H00_RS03750	COG0359	binds to the 23S rRNA
A4H00_RS03760	COG0445	tRNA wobble uridine modification
A4H00_RS03765	COG2816	NAD+ diphosphatase activity
A4H00_RS03775	COG0482	sulfurtransferase activity
A4H00_RS03780	COG1760	l-serine dehydratase
A4H00_RS03785	COG1760	l-serine dehydratase
A4H00_RS03795	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A4H00_RS03800	COG1122	ATPase activity
A4H00_RS03805	COG1122	ATPase activity
A4H00_RS03810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4H00_RS03820	COG0612	Peptidase, M16
A4H00_RS03825	COG0612	Peptidase, M16
A4H00_RS03830	COG2501	S4 domain
A4H00_RS03835	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4H00_RS03845	COG0517	IMP dehydrogenase activity
A4H00_RS03845	COG0516	GMP reductase activity
A4H00_RS03850	COG0180	Tryptophanyl-tRNA synthetase
A4H00_RS03855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4H00_RS03860	COG0488	(ABC) transporter
A4H00_RS03870	COG2826	transposase and inactivated derivatives, IS30 family
A4H00_RS03895	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4H00_RS03900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4H00_RS03905	COG1475	DNA binding
A4H00_RS03915	COG0592	DNA-directed DNA polymerase activity
A4H00_RS03935	COG0012	GTP binding
A4H00_RS03940	COG0193	aminoacyl-tRNA hydrolase activity
A4H00_RS03945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4H00_RS03950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4H00_RS03965	COG0037	tRNA processing
A4H00_RS03975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4H00_RS04105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4H00_RS04110	COG0436	Aminotransferase
A4H00_RS04115	COG1381	Involved in DNA repair and RecF pathway recombination
A4H00_RS04125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4H00_RS04145	COG0416	fatty acid biosynthetic process
A4H00_RS04150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4H00_RS04155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4H00_RS04160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4H00_RS04175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4H00_RS04210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4H00_RS04230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4H00_RS04235	COG2255	four-way junction helicase activity
A4H00_RS04240	COG0546	phosphoglycolate phosphatase activity
A4H00_RS04250	COG2826	transposase and inactivated derivatives, IS30 family
A4H00_RS04255	COG0051	transcription antitermination factor activity, RNA binding
A4H00_RS04260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4H00_RS04265	COG0088	Forms part of the polypeptide exit tunnel
A4H00_RS04270	COG0089	rRNA binding
A4H00_RS04275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4H00_RS04280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4H00_RS04285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4H00_RS04290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4H00_RS04300	COG0255	Belongs to the universal ribosomal protein uL29 family
A4H00_RS04305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4H00_RS04310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4H00_RS04315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4H00_RS04320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4H00_RS04325	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4H00_RS04330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4H00_RS04335	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4H00_RS04340	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4H00_RS04350	COG0200	Binds to the 23S rRNA
A4H00_RS04355	COG0201	protein transport
A4H00_RS04360	COG0563	adenylate kinase activity
A4H00_RS04365	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4H00_RS04370	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4H00_RS04380	COG0202	RNA polymerase activity
A4H00_RS04395	COG3335	DDE superfamily endonuclease
A4H00_RS04490	COG1846	Transcriptional regulator
A4H00_RS04495	COG1121	(ABC) transporter
A4H00_RS04500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4H00_RS04505	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4H00_RS04505	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4H00_RS04535	COG0085	RNA polymerase activity
A4H00_RS04540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4H00_RS04555	COG0049	tRNA binding
A4H00_RS04560	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4H00_RS04605	COG0126	phosphoglycerate kinase activity
A4H00_RS04615	COG0789	Transcriptional regulator
A4H00_RS04620	COG0174	glutamine synthetase
A4H00_RS04645	COG5503	Protein of unknown function (DUF1447)
A4H00_RS04980	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4H00_RS04980	COG1388	LysM domain
A4H00_RS04985	COG1214	PFAM Peptidase M22, glycoprotease
A4H00_RS04995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4H00_RS05025	COG1131	(ABC) transporter
A4H00_RS05030	COG2081	HI0933 family
A4H00_RS05060	COG2211	Major facilitator Superfamily
A4H00_RS05070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4H00_RS05085	COG3959	Transketolase, thiamine diphosphate binding domain
A4H00_RS05090	COG3958	Transketolase
A4H00_RS05110	COG1131	(ABC) transporter
A4H00_RS05145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4H00_RS05150	COG2222	sugar isomerase
A4H00_RS05175	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4H00_RS05180	COG1882	Formate acetyltransferase
A4H00_RS05215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4H00_RS05220	COG0681	Belongs to the peptidase S26 family
A4H00_RS05240	COG1193	negative regulation of DNA recombination
A4H00_RS05245	COG3583	domain protein
A4H00_RS05245	COG3525	Glycosyl hydrolase, family 20, catalytic domain
A4H00_RS05245	COG3064	Membrane
A4H00_RS05255	COG3118	belongs to the thioredoxin family
A4H00_RS05280	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4H00_RS05280	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4H00_RS05295	COG1846	Transcriptional regulator
A4H00_RS05300	COG1115	amino acid carrier protein
A4H00_RS05305	COG0668	transmembrane transport
A4H00_RS05320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4H00_RS05325	COG0167	dihydroorotate dehydrogenase activity
A4H00_RS05335	COG0561	phosphatase activity
A4H00_RS05355	COG4555	ABC transporter
A4H00_RS05370	COG1696	Membrane protein involved in D-alanine export
A4H00_RS05380	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A4H00_RS05405	COG1694	Mazg nucleotide pyrophosphohydrolase
A4H00_RS05425	COG1454	alcohol dehydrogenase
A4H00_RS05430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4H00_RS05435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A4H00_RS05460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4H00_RS05465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4H00_RS05480	COG0601	transmembrane transport
A4H00_RS05490	COG0444	Belongs to the ABC transporter superfamily
A4H00_RS05495	COG4608	Belongs to the ABC transporter superfamily
A4H00_RS05500	COG1454	alcohol dehydrogenase
A4H00_RS05500	COG1012	belongs to the aldehyde dehydrogenase family
A4H00_RS05505	COG3458	cephalosporin-C deacetylase activity
A4H00_RS05510	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A4H00_RS05520	COG1175	transmembrane transport
A4H00_RS05525	COG0395	ABC-type sugar transport system, permease component
A4H00_RS05540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4H00_RS05550	COG1737	Transcriptional regulator
A4H00_RS05555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4H00_RS05570	COG0534	Mate efflux family protein
A4H00_RS05575	COG0546	phosphoglycolate phosphatase activity
A4H00_RS05580	COG1846	Transcriptional regulator
A4H00_RS05585	COG3759	membrane
A4H00_RS05600	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4H00_RS05610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4H00_RS05615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4H00_RS05640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4H00_RS05645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4H00_RS05660	COG1862	Preprotein translocase
A4H00_RS05665	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4H00_RS05670	COG4589	Belongs to the CDS family
A4H00_RS05680	COG0442	prolyl-tRNA aminoacylation
A4H00_RS05685	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A4H00_RS05690	COG1461	Dihydroxyacetone kinase
A4H00_RS05695	COG2376	Dihydroxyacetone kinase
A4H00_RS05705	COG2376	Dihydroxyacetone kinase
A4H00_RS05710	COG2814	Major facilitator Superfamily
A4H00_RS05715	COG2176	DNA-directed DNA polymerase activity
A4H00_RS05720	COG1174	glycine betaine transport
A4H00_RS05730	COG2309	aminopeptidase activity
A4H00_RS05750	COG3335	DDE superfamily endonuclease
A4H00_RS05765	COG1739	Uncharacterized protein family UPF0029
A4H00_RS05770	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A4H00_RS05775	COG1040	competence protein
A4H00_RS05795	COG0747	negative chemotaxis
A4H00_RS05805	COG4608	Belongs to the ABC transporter superfamily
A4H00_RS05810	COG0601	transmembrane transport
A4H00_RS05815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4H00_RS05825	COG3335	DDE superfamily endonuclease
A4H00_RS05885	COG3557	Belongs to the UPF0374 family
A4H00_RS05890	COG2137	regulation of response to DNA damage stimulus
A4H00_RS05895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4H00_RS05905	COG1131	(ABC) transporter
A4H00_RS05935	COG2188	Transcriptional regulator
A4H00_RS05940	COG2188	Transcriptional regulator
A4H00_RS05950	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4H00_RS05955	COG3715	PTS system
A4H00_RS05960	COG3716	PTS system mannose fructose sorbose family IID component
A4H00_RS05970	COG2017	converts alpha-aldose to the beta-anomer
A4H00_RS05975	COG1113	amino acid transport
A4H00_RS06005	COG4988	ABC transporter
A4H00_RS06015	COG1396	sequence-specific DNA binding
A4H00_RS06030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4H00_RS06055	COG0519	Catalyzes the synthesis of GMP from XMP
A4H00_RS06075	COG0252	asparaginase activity
A4H00_RS06085	COG0589	response to stress
A4H00_RS06090	COG0436	Aminotransferase
A4H00_RS06095	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4H00_RS06100	COG1335	isochorismatase
A4H00_RS06105	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4H00_RS06110	COG0154	amidase activity
A4H00_RS06115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4H00_RS06120	COG0789	Transcriptional regulator
A4H00_RS06135	COG1609	Transcriptional regulator
A4H00_RS06140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4H00_RS06145	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A4H00_RS06150	COG0697	spore germination
A4H00_RS06155	COG3142	Participates in the control of copper homeostasis
A4H00_RS06160	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A4H00_RS06165	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A4H00_RS06170	COG1534	Rna-binding protein
A4H00_RS06175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4H00_RS06180	COG1713	HD superfamily hydrolase involved in NAD metabolism
A4H00_RS06185	COG0799	negative regulation of ribosome biogenesis
A4H00_RS06190	COG2226	methyltransferase
A4H00_RS06205	COG0242	peptide deformylase activity
A4H00_RS06210	COG2188	Transcriptional regulator
A4H00_RS06215	COG1640	4-alpha-glucanotransferase
A4H00_RS06220	COG0058	SHG alpha-glucan phosphorylase activity
A4H00_RS06230	COG2190	(PTS) system
A4H00_RS06230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4H00_RS06230	COG1263	PTS System
A4H00_RS06240	COG4619	ABC transporter
A4H00_RS06255	COG0217	transcriptional regulatory protein
A4H00_RS06280	COG1304	FMN binding
A4H00_RS06295	COG1846	Transcriptional regulator
A4H00_RS06305	COG1132	(ABC) transporter
A4H00_RS06310	COG1832	CoA-binding protein
A4H00_RS06325	COG2822	iron ion transport
A4H00_RS06330	COG2837	iron assimilation
A4H00_RS06335	COG0672	)-iron permease
A4H00_RS06340	COG0805	protein transport
A4H00_RS06345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4H00_RS06350	COG2315	Protein conserved in bacteria
A4H00_RS06360	COG3711	transcriptional antiterminator
A4H00_RS06360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4H00_RS06395	COG1217	gtp-binding protein TYPA
A4H00_RS06410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4H00_RS06430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4H00_RS06435	COG1799	cell septum assembly
A4H00_RS06445	COG2302	S4 RNA-binding domain
A4H00_RS06450	COG3599	regulation of cell shape
A4H00_RS06460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4H00_RS06470	COG0494	nUDIX hydrolase
A4H00_RS06475	COG0542	response to heat
A4H00_RS06480	COG4703	Protein of unknown function (DUF1797)
A4H00_RS06485	COG0765	amino acid transport
A4H00_RS06490	COG1126	abc transporter atp-binding protein
A4H00_RS06495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4H00_RS06500	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4H00_RS06505	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4H00_RS06510	COG1242	4 iron, 4 sulfur cluster binding
A4H00_RS06515	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4H00_RS06525	COG0025	NhaP-type Na H and K H
A4H00_RS06530	COG1846	Transcriptional regulator
A4H00_RS06540	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4H00_RS06545	COG1119	ATPase activity
A4H00_RS06550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4H00_RS06555	COG1253	flavin adenine dinucleotide binding
A4H00_RS06560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4H00_RS06580	COG1227	inorganic diphosphatase activity
A4H00_RS06590	COG1121	(ABC) transporter
A4H00_RS06610	COG5002	protein histidine kinase activity
A4H00_RS06615	COG1136	(ABC) transporter
A4H00_RS06620	COG0577	efflux transmembrane transporter activity
A4H00_RS06630	COG1028	Short-chain dehydrogenase reductase Sdr
A4H00_RS06640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4H00_RS06645	COG0494	nUDIX hydrolase
A4H00_RS06660	COG1442	glycosyl transferase family 8
A4H00_RS06675	COG0438	transferase activity, transferring glycosyl groups
A4H00_RS06680	COG0201	protein transport
A4H00_RS06700	COG0653	protein targeting
A4H00_RS06705	COG0438	transferase activity, transferring glycosyl groups
A4H00_RS06740	COG0697	spore germination
A4H00_RS06740	COG1674	ftsk spoiiie
A4H00_RS06745	COG0346	lactoylglutathione lyase activity
A4H00_RS06770	COG0625	glutathione transferase activity
A4H00_RS06780	COG2244	polysaccharide biosynthetic process
A4H00_RS06785	COG0528	UMP kinase activity
A4H00_RS06790	COG0233	cytoplasmic translational termination
A4H00_RS06795	COG2996	Protein conserved in bacteria
A4H00_RS06800	COG1686	Belongs to the peptidase S11 family
A4H00_RS06805	COG4479	Belongs to the UPF0346 family
A4H00_RS06810	COG1702	phosphate starvation-inducible protein PhoH
A4H00_RS06835	COG3711	transcriptional antiterminator
A4H00_RS06840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4H00_RS06840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4H00_RS06840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4H00_RS06845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4H00_RS06850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4H00_RS06860	COG1132	(ABC) transporter
A4H00_RS06865	COG1132	(ABC) transporter
A4H00_RS06875	COG2723	6-phospho-beta-galactosidase activity
A4H00_RS06885	COG3711	transcriptional antiterminator
A4H00_RS06895	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4H00_RS06905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4H00_RS06910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4H00_RS06925	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4H00_RS06930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4H00_RS06940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4H00_RS06945	COG0237	dephospho-CoA kinase activity
A4H00_RS06950	COG2814	Major facilitator Superfamily
A4H00_RS06960	COG0557	exoribonuclease II activity
A4H00_RS06965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4H00_RS06975	COG1621	beta-fructofuranosidase activity
A4H00_RS06985	COG2217	Heavy metal translocating P-type atpase
A4H00_RS06990	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4H00_RS06995	COG0577	efflux transmembrane transporter activity
A4H00_RS06995	COG1136	(ABC) transporter
A4H00_RS07025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4H00_RS07025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4H00_RS07030	COG2131	deaminase
A4H00_RS07035	COG4152	abc transporter atp-binding protein
A4H00_RS07040	COG1668	transmembrane transport
A4H00_RS07050	COG1363	Peptidase, m42
A4H00_RS07065	COG0343	queuine tRNA-ribosyltransferase activity
A4H00_RS07080	COG2910	NAD(P)H-binding
A4H00_RS07090	COG1846	Transcriptional regulator
A4H00_RS07095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4H00_RS07100	COG4221	oxidoreductase activity
A4H00_RS07105	COG3759	membrane
A4H00_RS07130	COG0438	transferase activity, transferring glycosyl groups
A4H00_RS07135	COG0438	transferase activity, transferring glycosyl groups
A4H00_RS07150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4H00_RS07160	COG1064	alcohol dehydrogenase
A4H00_RS07180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4H00_RS07245	COG0745	RESPONSE REGULATOR receiver
A4H00_RS07255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4H00_RS07260	COG0488	(ABC) transporter
A4H00_RS07265	COG0768	penicillin binding
A4H00_RS07270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4H00_RS07275	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4H00_RS07280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4H00_RS07290	COG2826	transposase and inactivated derivatives, IS30 family
A4H00_RS07295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4H00_RS07315	COG0513	Belongs to the DEAD box helicase family
A4H00_RS07325	COG1476	TRANSCRIPTIONal
A4H00_RS07355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4H00_RS07360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4H00_RS07365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A4H00_RS07370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4H00_RS07380	COG3118	belongs to the thioredoxin family
A4H00_RS07400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4H00_RS07420	COG1136	(ABC) transporter
A4H00_RS07425	COG0745	RESPONSE REGULATOR receiver
A4H00_RS07430	COG5002	protein histidine kinase activity
A4H00_RS07440	COG2807	transmembrane transport
A4H00_RS07480	COG1131	(ABC) transporter
A4H00_RS07485	COG1396	sequence-specific DNA binding
A4H00_RS07495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4H00_RS07500	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4H00_RS07510	COG1234	tRNA 3'-trailer cleavage
A4H00_RS07515	COG0300	oxidoreductase activity
A4H00_RS07520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4H00_RS07535	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A4H00_RS07535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4H00_RS07540	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4H00_RS07545	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4H00_RS07555	COG2384	SAM-dependent methyltransferase
A4H00_RS07565	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4H00_RS07580	COG1088	dTDP-glucose 4,6-dehydratase activity
A4H00_RS07590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4H00_RS07595	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4H00_RS07600	COG2884	Cell division ATP-binding protein ftsE
A4H00_RS07605	COG2177	Part of the ABC transporter FtsEX involved in
A4H00_RS07625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4H00_RS07625	COG1199	ATP-dependent helicase activity
A4H00_RS07650	COG4555	ABC transporter
A4H00_RS07665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4H00_RS07670	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4H00_RS07675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4H00_RS07705	COG1272	protein, Hemolysin III
A4H00_RS07735	COG5353	protein conserved in bacteria
A4H00_RS07740	COG0436	Aminotransferase
A4H00_RS07745	COG0017	Asparaginyl-tRNA synthetase
A4H00_RS07755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4H00_RS07765	COG0251	oxidation-reduction process
A4H00_RS07770	COG1660	Displays ATPase and GTPase activities
A4H00_RS07775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4H00_RS07780	COG1481	regulation of sporulation
A4H00_RS07785	COG4868	Belongs to the UPF0371 family
A4H00_RS07800	COG0561	phosphatase activity
A4H00_RS07805	COG0561	phosphatase activity
A4H00_RS07810	COG0552	protein localization to endoplasmic reticulum
A4H00_RS07815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4H00_RS07820	COG3689	TIGRFAM TIGR03943 family protein
A4H00_RS07825	COG0701	Predicted permease
A4H00_RS07835	COG1597	lipid kinase activity
A4H00_RS07845	COG0356	it plays a direct role in the translocation of protons across the membrane
A4H00_RS07850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4H00_RS07855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4H00_RS07860	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4H00_RS07865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4H00_RS07875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4H00_RS07880	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4H00_RS07910	COG2211	Major facilitator Superfamily
A4H00_RS07920	COG3250	beta-galactosidase activity
A4H00_RS07935	COG0800	Aldolase
A4H00_RS07945	COG1312	Catalyzes the dehydration of D-mannonate
A4H00_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
A4H00_RS07975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4H00_RS07975	COG0072	phenylalanine-tRNA ligase activity
A4H00_RS07985	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4H00_RS07990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4H00_RS08000	COG3859	Proton-coupled thiamine transporter YuaJ
A4H00_RS08020	COG0772	Belongs to the SEDS family
A4H00_RS08025	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
A4H00_RS08050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4H00_RS08055	COG0149	triose-phosphate isomerase activity
A4H00_RS08070	COG2348	transferase activity, transferring amino-acyl groups
A4H00_RS08090	COG1078	dGTPase activity
A4H00_RS08110	COG3177	Filamentation induced by cAMP protein fic
A4H00_RS08125	COG1091	dTDP-4-dehydrorhamnose reductase activity
A4H00_RS08135	COG1215	transferase activity, transferring glycosyl groups
A4H00_RS08150	COG1442	glycosyl transferase family 8
A4H00_RS08150	COG1216	Glycosyl transferase, family 2
A4H00_RS08200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4H00_RS08210	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4H00_RS08225	COG2706	6-phosphogluconolactonase activity
A4H00_RS08230	COG0628	permease
A4H00_RS08240	COG3527	Alpha-acetolactate decarboxylase
A4H00_RS08250	COG1051	belongs to the nudix hydrolase family
A4H00_RS08255	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A4H00_RS08275	COG0785	Cytochrome C biogenesis protein
A4H00_RS08280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4H00_RS08285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4H00_RS08285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4H00_RS08290	COG2197	response regulator
A4H00_RS08295	COG2972	Histidine kinase
A4H00_RS08310	COG0210	DNA helicase
A4H00_RS08315	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A4H00_RS08320	COG1074	ATP-dependent DNA helicase activity
A4H00_RS08345	COG0488	(ABC) transporter
A4H00_RS08360	COG4211	Belongs to the binding-protein-dependent transport system permease family
A4H00_RS08365	COG0481	GTPase activity
A4H00_RS08375	COG2217	Heavy metal translocating P-type atpase
A4H00_RS08380	COG1126	abc transporter atp-binding protein
A4H00_RS08385	COG0765	amino acid transport
A4H00_RS08395	COG0556	nucleotide-excision repair
A4H00_RS08400	COG1316	TRANSCRIPTIONal
A4H00_RS08405	COG4464	protein tyrosine phosphatase activity
A4H00_RS08410	COG3944	biosynthesis protein
A4H00_RS08425	COG1216	Glycosyl transferase, family 2
A4H00_RS08435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4H00_RS08440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4H00_RS08450	COG0438	transferase activity, transferring glycosyl groups
A4H00_RS08460	COG3475	LICD family
A4H00_RS08465	COG3475	LICD family
A4H00_RS08510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4H00_RS08520	COG0297	glycogen (starch) synthase activity
A4H00_RS08525	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4H00_RS08530	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4H00_RS08535	COG0583	DNA-binding transcription factor activity
A4H00_RS08540	COG0543	2 iron, 2 sulfur cluster binding
A4H00_RS08545	COG0167	dihydroorotate dehydrogenase activity
A4H00_RS08550	COG0284	orotidine-5'-phosphate decarboxylase activity
A4H00_RS08565	COG0463	Glycosyl transferase, family 2
A4H00_RS08570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4H00_RS08575	COG1051	belongs to the nudix hydrolase family
A4H00_RS08585	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A4H00_RS08590	COG0187	DNA topoisomerase II activity
A4H00_RS08595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4H00_RS08600	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4H00_RS08620	COG0539	negative regulation of cytoplasmic translation
A4H00_RS08640	COG1104	cysteine desulfurase activity
A4H00_RS08645	COG0301	tRNA thio-modification
A4H00_RS08660	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4H00_RS08665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4H00_RS08675	COG2207	Transcriptional regulator
A4H00_RS08680	COG1621	beta-fructofuranosidase activity
A4H00_RS08690	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4H00_RS08695	COG4988	ABC transporter
A4H00_RS08700	COG1294	oxidase, subunit
A4H00_RS08705	COG1271	oxidase subunit
A4H00_RS08710	COG1252	NADH dehydrogenase
A4H00_RS08735	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4H00_RS08740	COG0196	riboflavin kinase activity
A4H00_RS08745	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4H00_RS08750	COG1393	Belongs to the ArsC family
A4H00_RS08760	COG0483	inositol monophosphate 1-phosphatase activity
A4H00_RS08765	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A4H00_RS08765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4H00_RS08775	COG0573	inorganic phosphate transmembrane transporter activity
A4H00_RS08780	COG0581	inorganic phosphate transmembrane transporter activity
A4H00_RS08785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4H00_RS08790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4H00_RS08795	COG0704	Plays a role in the regulation of phosphate uptake
A4H00_RS08800	COG0745	RESPONSE REGULATOR receiver
A4H00_RS08815	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4H00_RS08815	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4H00_RS08825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4H00_RS08830	COG1349	DNA-binding transcription factor activity
A4H00_RS08835	COG1105	Belongs to the carbohydrate kinase PfkB family
A4H00_RS08840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4H00_RS08840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4H00_RS08840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4H00_RS08850	COG1307	EDD domain protein, DegV family
A4H00_RS08855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4H00_RS08860	COG0617	tRNA 3'-terminal CCA addition
A4H00_RS08865	COG0488	(ABC) transporter
A4H00_RS08875	COG1940	carbohydrate kinase activity
A4H00_RS08880	COG0583	DNA-binding transcription factor activity
A4H00_RS08890	COG0564	pseudouridine synthase activity
A4H00_RS08895	COG2824	Alkylphosphonate utilization operon protein PhnA
A4H00_RS08910	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A4H00_RS08915	COG0540	Belongs to the ATCase OTCase family
A4H00_RS08920	COG0505	Belongs to the CarA family
A4H00_RS08935	COG2136	Putative SAM-dependent methyltransferase
A4H00_RS08935	COG2521	methyltransferase
A4H00_RS08945	COG0228	four-way junction DNA binding
A4H00_RS08955	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4H00_RS08975	COG1072	(Pantothenic acid kinase))
A4H00_RS08980	COG2813	Specifically methylates the guanine in position
A4H00_RS08995	COG0295	cytidine deaminase activity
A4H00_RS09000	COG1744	ABC transporter substrate-binding protein PnrA-like
A4H00_RS09005	COG3845	ABC transporter
A4H00_RS09010	COG4603	Belongs to the binding-protein-dependent transport system permease family
A4H00_RS09015	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4H00_RS09020	COG0039	L-malate dehydrogenase activity
A4H00_RS09025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4H00_RS09030	COG3764	Sortase (surface protein transpeptidase)
A4H00_RS09040	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A4H00_RS09060	COG1104	cysteine desulfurase activity
A4H00_RS09075	COG2357	RelA SpoT domain protein
A4H00_RS09080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4H00_RS09085	COG0564	pseudouridine synthase activity
A4H00_RS09090	COG0280	phosphate acetyltransferase
A4H00_RS09095	COG1132	(ABC) transporter
A4H00_RS09100	COG1132	(ABC) transporter
A4H00_RS09125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4H00_RS09130	COG4684	Psort location CytoplasmicMembrane, score
A4H00_RS09135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4H00_RS09145	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A4H00_RS09170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4H00_RS09180	COG0789	Transcriptional regulator
A4H00_RS09185	COG1132	(ABC) transporter
A4H00_RS09195	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4H00_RS09205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4H00_RS09210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4H00_RS09215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4H00_RS09225	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4H00_RS09245	COG1164	Oligoendopeptidase f
A4H00_RS09265	COG3321	synthase
A4H00_RS09265	COG1028	Short-chain dehydrogenase reductase Sdr
A4H00_RS09265	COG0604	alcohol dehydrogenase
A4H00_RS09270	COG0596	Alpha beta hydrolase
A4H00_RS09275	COG4221	oxidoreductase activity
A4H00_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
A4H00_RS09285	COG1902	pentaerythritol trinitrate reductase activity
A4H00_RS09285	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4H00_RS09325	COG1960	acyl-CoA dehydrogenase activity
A4H00_RS09330	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4H00_RS09335	COG0183	Belongs to the thiolase family
A4H00_RS09360	COG2184	nucleotidyltransferase activity
A4H00_RS09365	COG2801	Transposase and inactivated derivatives
A4H00_RS09375	COG1024	Enoyl-CoA hydratase
A4H00_RS09380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4H00_RS09385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4H00_RS09390	COG0583	DNA-binding transcription factor activity
A4H00_RS09395	COG1960	acyl-CoA dehydrogenase activity
A4H00_RS09400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4H00_RS09420	COG3243	poly(R)-hydroxyalkanoic acid synthase
A4H00_RS09430	COG2030	dehydratase
A4H00_RS09440	COG2826	transposase and inactivated derivatives, IS30 family
A4H00_RS09475	COG2801	Transposase and inactivated derivatives
A4H00_RS09485	COG0583	DNA-binding transcription factor activity
A4H00_RS09495	COG1476	TRANSCRIPTIONal
A4H00_RS09510	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A4H00_RS09515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4H00_RS09520	COG0110	maltose O-acetyltransferase activity
A4H00_RS09525	COG0758	DNA mediated transformation
A4H00_RS09530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4H00_RS09535	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A4H00_RS09540	COG0789	Transcriptional regulator
A4H00_RS09560	COG3711	transcriptional antiterminator
A4H00_RS09565	COG1263	PTS System
A4H00_RS09565	COG2190	(PTS) system
A4H00_RS09565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4H00_RS09590	COG1136	(ABC) transporter
A4H00_RS09600	COG0745	RESPONSE REGULATOR receiver
A4H00_RS09625	COG4974	Belongs to the 'phage' integrase family
A4H00_RS09635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4H00_RS09645	COG2188	Transcriptional regulator
A4H00_RS09660	COG4221	oxidoreductase activity
A4H00_RS09675	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4H00_RS09685	COG2890	protein-(glutamine-N5) methyltransferase activity
A4H00_RS09690	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4H00_RS09695	COG1435	thymidine kinase activity
A4H00_RS09700	COG1942	4-Oxalocrotonate Tautomerase
A4H00_RS09705	COG0534	Mate efflux family protein
A4H00_RS09710	COG5002	protein histidine kinase activity
A4H00_RS09735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4H00_RS09740	COG0577	efflux transmembrane transporter activity
A4H00_RS09740	COG1136	(ABC) transporter
A4H00_RS09760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4H00_RS09765	COG1177	transmembrane transport
A4H00_RS09770	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4H00_RS09780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4H00_RS09790	COG0083	homoserine kinase activity
A4H00_RS09795	COG0460	homoserine dehydrogenase
A4H00_RS09800	COG0726	polysaccharide deacetylase
A4H00_RS09840	COG4869	propanediol catabolic process
A4H00_RS09845	COG1454	alcohol dehydrogenase
A4H00_RS09845	COG1012	belongs to the aldehyde dehydrogenase family
A4H00_RS09860	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A4H00_RS09890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4H00_RS09895	COG1882	Formate acetyltransferase
A4H00_RS09900	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4H00_RS09905	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A4H00_RS09910	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
A4H00_RS09930	COG0789	Transcriptional regulator
A4H00_RS09930	COG4978	Transcriptional regulator
A4H00_RS09935	COG1454	alcohol dehydrogenase
A4H00_RS09940	COG0235	Class ii aldolase
A4H00_RS09960	COG2211	Major facilitator Superfamily
A4H00_RS09960	COG2190	(PTS) system
A4H00_RS09965	COG3250	beta-galactosidase activity
A4H00_RS09970	COG3408	Glycogen debranching enzyme
A4H00_RS09980	COG1472	Belongs to the glycosyl hydrolase 3 family
A4H00_RS09995	COG3250	beta-galactosidase activity
A4H00_RS10005	COG2211	Major facilitator Superfamily
A4H00_RS10010	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4H00_RS10015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4H00_RS10020	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4H00_RS10025	COG2723	6-phospho-beta-galactosidase activity
A4H00_RS10045	COG2801	Transposase and inactivated derivatives
A4H00_RS10075	COG3507	Belongs to the glycosyl hydrolase 43 family
A4H00_RS10105	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4H00_RS10115	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A4H00_RS10125	COG0395	ABC-type sugar transport system, permease component
A4H00_RS10140	COG2207	Transcriptional regulator
A4H00_RS10145	COG0142	geranyltranstransferase activity
A4H00_RS10165	COG0745	RESPONSE REGULATOR receiver
A4H00_RS10165	COG3292	Two component regulator propeller
A4H00_RS10165	COG2205	protein histidine kinase activity
A4H00_RS10170	COG0561	phosphatase activity
A4H00_RS10175	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4H00_RS10180	COG1476	TRANSCRIPTIONal
A4H00_RS10205	COG0577	efflux transmembrane transporter activity
A4H00_RS10205	COG1136	(ABC) transporter
A4H00_RS10215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4H00_RS10225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4H00_RS10230	COG1126	abc transporter atp-binding protein
A4H00_RS10235	COG0765	amino acid transport
A4H00_RS10240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4H00_RS10250	COG2755	lipolytic protein G-D-S-L family
A4H00_RS10250	COG0657	acetylesterase activity
A4H00_RS10255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4H00_RS10275	COG0469	pyruvate kinase activity
A4H00_RS10280	COG0205	6-phosphofructokinase activity
A4H00_RS10295	COG1131	(ABC) transporter
A4H00_RS10305	COG1523	belongs to the glycosyl hydrolase 13 family
A4H00_RS10310	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4H00_RS10335	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4H00_RS10335	COG1388	LysM domain
A4H00_RS10505	COG0582	viral genome integration into host DNA
A4H00_RS10600	COG3561	AntA/AntB antirepressor
A4H00_RS10625	COG3645	SOS response
A4H00_RS10630	COG0582	viral genome integration into host DNA
A4H00_RS10645	COG2151	metal-sulfur cluster biosynthetic enzyme
A4H00_RS10650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4H00_RS10655	COG0358	DNA primase activity
A4H00_RS10660	COG1970	mechanosensitive ion channel activity
A4H00_RS10665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4H00_RS10670	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4H00_RS10680	COG0647	UMP catabolic process
A4H00_RS10740	COG2274	protein secretion by the type I secretion system
A4H00_RS10745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4H00_RS10750	COG3290	protein histidine kinase activity
A4H00_RS10770	COG1051	belongs to the nudix hydrolase family
A4H00_RS10780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4H00_RS10785	COG0058	SHG alpha-glucan phosphorylase activity
A4H00_RS10790	COG0813	purine-nucleoside phosphorylase activity
A4H00_RS10805	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A4H00_RS10810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A4H00_RS10815	COG1704	LemA family
A4H00_RS10825	COG1573	uracil-dna glycosylase
A4H00_RS10835	COG0488	(ABC) transporter
A4H00_RS10840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4H00_RS10845	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4H00_RS10850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4H00_RS10855	COG3442	glutamine amidotransferase
A4H00_RS10860	COG5416	Lipopolysaccharide assembly protein A domain
A4H00_RS10865	COG0488	(ABC) transporter
A4H00_RS10890	COG1011	Hydrolase
A4H00_RS10910	COG2801	Transposase and inactivated derivatives
A4H00_RS10920	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4H00_RS10925	COG1937	Protein conserved in bacteria
A4H00_RS10935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4H00_RS10940	COG2873	o-acetylhomoserine
A4H00_RS10950	COG0534	Mate efflux family protein
A4H00_RS10965	COG1132	(ABC) transporter
A4H00_RS11030	COG1136	(ABC) transporter
A4H00_RS11035	COG1196	nuclear chromosome segregation
A4H00_RS11095	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4H00_RS11115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4H00_RS11125	COG0077	Prephenate dehydratase
A4H00_RS11145	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4H00_RS11150	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4H00_RS11155	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4H00_RS11160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4H00_RS11170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4H00_RS11175	COG4120	Belongs to the binding-protein-dependent transport system permease family
A4H00_RS11190	COG3679	Belongs to the UPF0342 family
A4H00_RS11195	COG0287	Prephenate dehydrogenase
A4H00_RS11200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4H00_RS11210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4H00_RS11215	COG1368	sulfuric ester hydrolase activity