locus-tag	class	description
smi_0002	COG0592	DNA-directed DNA polymerase activity
smi_0004	COG0012	GTP binding
smi_0006	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
smi_0007	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
smi_0011	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
smi_0012	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
smi_0014	COG2826	transposase and inactivated derivatives, IS30 family
smi_0026	COG0756	dUTP diphosphatase activity
smi_0028	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
smi_0032	COG2826	transposase and inactivated derivatives, IS30 family
smi_0033	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
smi_0041	COG4372	Transposase
smi_0042	COG2826	transposase and inactivated derivatives, IS30 family
smi_0046	COG3335	DDE superfamily endonuclease
smi_0048	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
smi_0048	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
smi_0049	COG1832	CoA-binding protein
smi_0050	COG2855	membrane
smi_0051	COG0436	Aminotransferase
smi_0054	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
smi_0064	COG2274	protein secretion by the type I secretion system
smi_0065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
smi_0067	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
smi_0068	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
smi_0069	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
smi_0070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
smi_0072	COG0138	bifunctional purine biosynthesis protein purh
smi_0073	COG0151	Belongs to the GarS family
smi_0074	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
smi_0076	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
smi_0080	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
smi_0082	COG3716	PTS system mannose fructose sorbose family IID component
smi_0084	COG2222	sugar isomerase
smi_0088	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
smi_0089	COG0569	domain protein
smi_0090	COG1215	transferase activity, transferring glycosyl groups
smi_0093	COG5002	protein histidine kinase activity
smi_0105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
smi_0107	COG2826	transposase and inactivated derivatives, IS30 family
smi_0108	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
smi_0111	COG3959	Transketolase, thiamine diphosphate binding domain
smi_0112	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
smi_0114	COG2151	metal-sulfur cluster biosynthetic enzyme
smi_0120	COG1476	TRANSCRIPTIONal
smi_0128	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
smi_0129	COG1609	Transcriptional regulator
smi_0130	COG5521	maltodextrose utilization protein MalA
smi_0131	COG3833	ABC-type maltose transport systems, permease component
smi_0132	COG1175	transmembrane transport
smi_0133	COG2182	Extracellular solute-binding protein
smi_0134	COG1640	4-alpha-glucanotransferase
smi_0135	COG0058	SHG alpha-glucan phosphorylase activity
smi_0136	COG2226	methyltransferase
smi_0138	COG2217	Heavy metal translocating P-type atpase
smi_0140	COG2826	transposase and inactivated derivatives, IS30 family
smi_0142	COG0697	spore germination
smi_0145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
smi_0147	COG1210	Utp--glucose-1-phosphate uridylyltransferase
smi_0151	COG1438	arginine binding
smi_0153	COG1132	(ABC) transporter
smi_0154	COG1132	(ABC) transporter
smi_0155	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
smi_0157	COG0166	Belongs to the GPI family
smi_0180	COG0582	viral genome integration into host DNA
smi_0186	COG1674	ftsk spoiiie
smi_0194	COG0534	Mate efflux family protein
smi_0195	COG0546	phosphoglycolate phosphatase activity
smi_0197	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
smi_0201	COG2826	transposase and inactivated derivatives, IS30 family
smi_0203	COG1063	alcohol dehydrogenase
smi_0205	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
smi_0206	COG1459	type II secretion system
smi_0207	COG4537	Required for transformation and DNA binding
smi_0216	COG0706	membrane insertase activity
smi_0219	COG3037	sugar-specific permease SgaT UlaA
smi_0221	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
smi_0223	COG3623	hexulose-6-phosphate isomerase
smi_0227	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
smi_0229	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
smi_0231	COG1012	belongs to the aldehyde dehydrogenase family
smi_0231	COG1454	alcohol dehydrogenase
smi_0234	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
smi_0235	COG2826	transposase and inactivated derivatives, IS30 family
smi_0236	COG0267	Belongs to the bacterial ribosomal protein bL33 family
smi_0240	COG2826	transposase and inactivated derivatives, IS30 family
smi_0256	COG1131	(ABC) transporter
smi_0257	COG0842	Transport permease protein
smi_0258	COG4585	Histidine kinase
smi_0259	COG2197	response regulator
smi_0260	COG2826	transposase and inactivated derivatives, IS30 family
smi_0264	COG2176	DNA-directed DNA polymerase activity
smi_0265	COG3041	Addiction module toxin RelE StbE family
smi_0266	COG2309	aminopeptidase activity
smi_0267	COG1187	pseudouridine synthase activity
smi_0268	COG3579	cysteine-type endopeptidase activity
smi_0272	COG3716	PTS system mannose fructose sorbose family IID component
smi_0273	COG3715	PTS system
smi_0275	COG1064	alcohol dehydrogenase
smi_0276	COG0561	phosphatase activity
smi_0277	COG2252	PERMEase
smi_0279	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
smi_0280	COG0285	dihydrofolate synthase activity
smi_0282	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
smi_0282	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
smi_0284	COG1609	Transcriptional regulator
smi_0285	COG0252	asparaginase activity
smi_0286	COG0561	phosphatase activity
smi_0287	COG0589	response to stress
smi_0289	COG0436	Aminotransferase
smi_0291	COG4166	transmembrane transport
smi_0292	COG0531	amino acid
smi_0293	COG0084	hydrolase, TatD family'
smi_0296	COG1162	GTPase activity
smi_0298	COG1564	THIamine pyrophosphokinase
smi_0301	COG2826	transposase and inactivated derivatives, IS30 family
smi_0302	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
smi_0304	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
smi_0311	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
smi_0314	COG0742	ribosomal rna small subunit methyltransferase
smi_0316	COG3480	Lon protease (S16) C-terminal proteolytic domain
smi_0317	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
smi_0320	COG1253	flavin adenine dinucleotide binding
smi_0322	COG4166	transmembrane transport
smi_0323	COG0601	transmembrane transport
smi_0324	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
smi_0325	COG0444	Belongs to the ABC transporter superfamily
smi_0326	COG4608	Belongs to the ABC transporter superfamily
smi_0328	COG4120	Belongs to the binding-protein-dependent transport system permease family
smi_0329	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
smi_0339	COG1187	pseudouridine synthase activity
smi_0341	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
smi_0342	COG1363	Peptidase, m42
smi_0348	COG0789	Transcriptional regulator
smi_0349	COG0174	glutamine synthetase
smi_0357	COG0484	heat shock protein binding
smi_0360	COG0537	adenosine 5'-monophosphoramidase activity
smi_0361	COG1131	(ABC) transporter
smi_0366	COG3290	protein histidine kinase activity
smi_0376	COG0195	Participates in both transcription termination and antitermination
smi_0377	COG2740	Nucleic-acid-binding protein implicated in transcription termination
smi_0389	COG0525	valine-tRNA ligase activity
smi_0399	COG2826	transposase and inactivated derivatives, IS30 family
smi_0401	COG0504	CTP synthase activity
smi_0404	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
smi_0405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
smi_0406	COG4221	oxidoreductase activity
smi_0422	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
smi_0442	COG3728	DNA packaging
smi_0442	COG5484	DNA packaging
smi_0467	COG3299	homolog of phage Mu protein gp47
smi_0478	COG5263	repeat protein
smi_0478	COG5632	N-Acetylmuramoyl-L-alanine amidase
smi_0488	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
smi_0511	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
smi_0511	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
smi_0512	COG2826	transposase and inactivated derivatives, IS30 family
smi_0515	COG0517	IMP dehydrogenase activity
smi_0515	COG1125	glycine betaine transport
smi_0516	COG1174	glycine betaine transport
smi_0518	COG1230	cation diffusion facilitator family transporter
smi_0519	COG1609	Transcriptional regulator
smi_0520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
smi_0521	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
smi_0527	COG2233	PERMEase
smi_0530	COG0708	Exodeoxyribonuclease III
smi_0532	COG0640	Transcriptional regulator
smi_0535	COG2323	membrane
smi_0536	COG1132	(ABC) transporter
smi_0537	COG1132	(ABC) transporter
smi_0538	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
smi_0539	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
smi_0541	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
smi_0542	COG0512	Glutamine amidotransferase of anthranilate synthase
smi_0545	COG0135	phosphoribosylanthranilate isomerase activity
smi_0548	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
smi_0550	COG3237	CsbD-like
smi_0554	COG2261	transglycosylase associated protein
smi_0555	COG3711	transcriptional antiterminator
smi_0557	COG1028	Short-chain dehydrogenase reductase Sdr
smi_0557	COG3321	synthase
smi_0557	COG0604	alcohol dehydrogenase
smi_0558	COG1959	2 iron, 2 sulfur cluster binding
smi_0560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
smi_0562	COG1051	belongs to the nudix hydrolase family
smi_0563	COG2264	protein methyltransferase activity
smi_0564	COG1385	rRNA (uridine-N3-)-methyltransferase activity
smi_0565	COG1164	Oligoendopeptidase f
smi_0568	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
smi_0571	COG0720	synthase
smi_0573	COG3118	belongs to the thioredoxin family
smi_0576	COG1380	Effector of murein hydrolase LrgA
smi_0577	COG1346	cytolysis
smi_0578	COG1136	(ABC) transporter
smi_0580	COG1131	(ABC) transporter
smi_0581	COG1725	Transcriptional regulator
smi_0584	COG1484	DNA-dependent DNA replication
smi_0589	COG0653	protein targeting
smi_0590	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
smi_0591	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
smi_0594	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
smi_0599	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
smi_0600	COG3458	cephalosporin-C deacetylase activity
smi_0604	COG1175	transmembrane transport
smi_0605	COG0395	ABC-type sugar transport system, permease component
smi_0606	COG2731	YhcH YjgK YiaL family protein
smi_0608	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
smi_0613	COG0768	penicillin binding
smi_0616	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
smi_0618	COG2826	transposase and inactivated derivatives, IS30 family
smi_0619	COG2826	transposase and inactivated derivatives, IS30 family
smi_0622	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
smi_0626	COG3599	regulation of cell shape
smi_0631	COG0577	efflux transmembrane transporter activity
smi_0631	COG1136	(ABC) transporter
smi_0633	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
smi_0637	COG2814	Major facilitator Superfamily
smi_0639	COG3590	peptidase
smi_0647	COG1959	2 iron, 2 sulfur cluster binding
smi_0649	COG0745	RESPONSE REGULATOR receiver
smi_0650	COG5002	protein histidine kinase activity
smi_0651	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
smi_0653	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
smi_0657	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
smi_0661	COG0204	Acyl-transferase
smi_0662	COG2826	transposase and inactivated derivatives, IS30 family
smi_0663	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
smi_0664	COG2384	SAM-dependent methyltransferase
smi_0665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
smi_0666	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
smi_0667	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
smi_0668	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
smi_0669	COG0463	Glycosyl transferase, family 2
smi_0673	COG2824	Alkylphosphonate utilization operon protein PhnA
smi_0677	COG0351	phosphomethylpyrimidine kinase
smi_0678	COG4720	Psort location CytoplasmicMembrane, score
smi_0679	COG0006	proline dipeptidase activity
smi_0680	COG3442	glutamine amidotransferase
smi_0681	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
smi_0682	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
smi_0683	COG0004	ammonium transporteR
smi_0685	COG0513	Belongs to the DEAD box helicase family
smi_0686	COG2826	transposase and inactivated derivatives, IS30 family
smi_0687	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
smi_0688	COG1335	isochorismatase
smi_0690	COG0577	efflux transmembrane transporter activity
smi_0691	COG1136	(ABC) transporter
smi_0692	COG0577	efflux transmembrane transporter activity
smi_0693	COG0745	RESPONSE REGULATOR receiver
smi_0694	COG5002	protein histidine kinase activity
smi_0695	COG0191	fructose-bisphosphate aldolase activity
smi_0699	COG0596	Alpha beta hydrolase
smi_0701	COG4555	ABC transporter
smi_0705	COG1404	Belongs to the peptidase S8 family
smi_0708	COG1242	4 iron, 4 sulfur cluster binding
smi_0709	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
smi_0711	COG0025	NhaP-type Na H and K H
smi_0715	COG0828	Belongs to the bacterial ribosomal protein bS21 family
smi_0720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
smi_0722	COG0647	UMP catabolic process
smi_0724	COG1396	sequence-specific DNA binding
smi_0728	COG1393	Belongs to the ArsC family
smi_0730	COG0483	inositol monophosphate 1-phosphatase activity
smi_0731	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
smi_0731	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
smi_0732	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
smi_0733	COG0573	inorganic phosphate transmembrane transporter activity
smi_0734	COG0581	inorganic phosphate transmembrane transporter activity
smi_0735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
smi_0736	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
smi_0737	COG0704	Plays a role in the regulation of phosphate uptake
smi_0738	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
smi_0739	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
smi_0740	COG3527	Alpha-acetolactate decarboxylase
smi_0743	COG3842	ATPase activity
smi_0747	COG2826	transposase and inactivated derivatives, IS30 family
smi_0751	COG4555	ABC transporter
smi_0753	COG1368	sulfuric ester hydrolase activity
smi_0754	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
smi_0759	COG0287	Prephenate dehydrogenase
smi_0765	COG0077	Prephenate dehydratase
smi_0767	COG3475	LICD family
smi_0769	COG1215	transferase activity, transferring glycosyl groups
smi_0775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
smi_0775	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
smi_0776	COG1132	(ABC) transporter
smi_0777	COG1132	(ABC) transporter
smi_0778	COG0402	S-adenosylhomocysteine deaminase activity
smi_0779	COG2826	transposase and inactivated derivatives, IS30 family
smi_0780	COG2826	transposase and inactivated derivatives, IS30 family
smi_0781	COG2826	transposase and inactivated derivatives, IS30 family
smi_0782	COG2826	transposase and inactivated derivatives, IS30 family
smi_0783	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
smi_0787	COG0270	DNA (cytosine-5-)-methyltransferase activity
smi_0792	COG1737	Transcriptional regulator
smi_0793	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
smi_0794	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
smi_0795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
smi_0797	COG0673	inositol 2-dehydrogenase activity
smi_0800	COG1269	ATP hydrolysis coupled proton transport
smi_0801	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
smi_0814	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
smi_0815	COG0167	dihydroorotate dehydrogenase activity
smi_0817	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
smi_0818	COG4470	Protein conserved in bacteria
smi_0819	COG0820	rRNA (adenine-C2-)-methyltransferase activity
smi_0821	COG0488	(ABC) transporter
smi_0831	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
smi_0831	COG1328	CTP reductase activity
smi_0834	COG1268	BioY protein
smi_0836	COG1136	(ABC) transporter
smi_0838	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
smi_0839	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
smi_0840	COG1136	(ABC) transporter
smi_0841	COG0577	efflux transmembrane transporter activity
smi_0842	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
smi_0842	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
smi_0843	COG4989	oxidoreductase activity
smi_0845	COG1028	Short-chain dehydrogenase reductase Sdr
smi_0851	COG0745	RESPONSE REGULATOR receiver
smi_0852	COG5002	protein histidine kinase activity
smi_0855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
smi_0855	COG1199	ATP-dependent helicase activity
smi_0856	COG0772	Belongs to the SEDS family
smi_0857	COG0693	protein deglycase activity
smi_0858	COG2826	transposase and inactivated derivatives, IS30 family
smi_0860	COG0187	DNA topoisomerase II activity
smi_0861	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
smi_0865	COG0542	response to heat
smi_0866	COG4703	Protein of unknown function (DUF1797)
smi_0867	COG0765	amino acid transport
smi_0868	COG1126	abc transporter atp-binding protein
smi_0869	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
smi_0871	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
smi_0876	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
smi_0879	COG0813	purine-nucleoside phosphorylase activity
smi_0882	COG0268	Binds directly to 16S ribosomal RNA
smi_0888	COG2813	Specifically methylates the guanine in position
smi_0889	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
smi_0891	COG0295	cytidine deaminase activity
smi_0892	COG1744	ABC transporter substrate-binding protein PnrA-like
smi_0893	COG3845	ABC transporter
smi_0894	COG4603	Belongs to the binding-protein-dependent transport system permease family
smi_0895	COG1079	Belongs to the binding-protein-dependent transport system permease family
smi_0897	COG0187	DNA topoisomerase II activity
smi_0905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
smi_0906	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
smi_0907	COG4166	transmembrane transport
smi_0911	COG0539	negative regulation of cytoplasmic translation
smi_0912	COG1956	GAF domain-containing protein
smi_0913	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
smi_0916	COG0719	Fe-S assembly protein
smi_0917	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
smi_0919	COG0719	Fe-S assembly protein
smi_0920	COG1686	Belongs to the peptidase S11 family
smi_0921	COG0628	permease
smi_0923	COG0513	Belongs to the DEAD box helicase family
smi_0925	COG2826	transposase and inactivated derivatives, IS30 family
smi_0928	COG0211	Belongs to the bacterial ribosomal protein bL27 family
smi_0929	COG2826	transposase and inactivated derivatives, IS30 family
smi_0930	COG0583	DNA-binding transcription factor activity
smi_0931	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
smi_0932	COG0564	pseudouridine synthase activity
smi_0933	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
smi_0934	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
smi_0937	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
smi_0939	COG0470	DNA polymerase III
smi_0949	COG0528	UMP kinase activity
smi_0951	COG2996	Protein conserved in bacteria
smi_0953	COG1702	phosphate starvation-inducible protein PhoH
smi_0954	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
smi_0955	COG1596	polysaccharide export
smi_0955	COG1555	photosystem II stabilization
smi_0956	COG2333	competence protein COMEC
smi_0956	COG0658	competence protein
smi_0957	COG1131	(ABC) transporter
smi_0963	COG2826	transposase and inactivated derivatives, IS30 family
smi_0964	COG0543	2 iron, 2 sulfur cluster binding
smi_0965	COG0167	dihydroorotate dehydrogenase activity
smi_0966	COG4193	domain, Protein
smi_0966	COG5263	repeat protein
smi_0967	COG1293	RNA-binding protein homologous to eukaryotic snRNP
smi_0969	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
smi_0971	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
smi_0972	COG0237	dephospho-CoA kinase activity
smi_0973	COG2814	Major facilitator Superfamily
smi_0974	COG0267	Belongs to the bacterial ribosomal protein bL33 family
smi_0976	COG0557	exoribonuclease II activity
smi_0978	COG0500	methyltransferase
smi_0978	COG3615	Tellurite resistance protein tehB
smi_0982	COG4122	O-methyltransferase activity
smi_0984	COG0772	Belongs to the SEDS family
smi_0985	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
smi_0986	COG2826	transposase and inactivated derivatives, IS30 family
smi_0987	COG2826	transposase and inactivated derivatives, IS30 family
smi_0991	COG0358	DNA primase activity
smi_0992	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
smi_0993	COG2151	metal-sulfur cluster biosynthetic enzyme
smi_0994	COG0438	transferase activity, transferring glycosyl groups
smi_0995	COG0438	transferase activity, transferring glycosyl groups
smi_1000	COG1438	arginine binding
smi_1001	COG2936	dipeptidyl-peptidase activity
smi_1005	COG0469	pyruvate kinase activity
smi_1007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
smi_1008	COG3764	Sortase (surface protein transpeptidase)
smi_1012	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
smi_1017	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
smi_1018	COG1438	arginine binding
smi_1019	COG0497	DNA recombination
smi_1020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
smi_1024	COG3775	system Galactitol-specific IIC component
smi_1029	COG3684	Belongs to the aldolase LacD family
smi_1030	COG0698	ribose 5-phosphate isomerase
smi_1032	COG1959	2 iron, 2 sulfur cluster binding
smi_1033	COG0697	spore germination
smi_1034	COG2226	methyltransferase
smi_1036	COG3711	transcriptional antiterminator
smi_1042	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
smi_1043	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
smi_1044	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
smi_1045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
smi_1049	COG2376	Dihydroxyacetone kinase
smi_1050	COG1309	transcriptional regulator
smi_1051	COG2376	Dihydroxyacetone kinase
smi_1052	COG1461	Dihydroxyacetone kinase
smi_1053	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
smi_1054	COG1011	Hydrolase
smi_1056	COG1051	belongs to the nudix hydrolase family
smi_1057	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
smi_1058	COG0534	Mate efflux family protein
smi_1061	COG0038	chloride channel
smi_1063	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
smi_1068	COG2826	transposase and inactivated derivatives, IS30 family
smi_1069	COG0561	phosphatase activity
smi_1070	COG1131	(ABC) transporter
smi_1072	COG2205	protein histidine kinase activity
smi_1073	COG0745	RESPONSE REGULATOR receiver
smi_1075	COG0577	efflux transmembrane transporter activity
smi_1076	COG1136	(ABC) transporter
smi_1081	COG2183	response to ionizing radiation
smi_1084	COG0701	Predicted permease
smi_1085	COG3689	TIGRFAM TIGR03943 family protein
smi_1087	COG2826	transposase and inactivated derivatives, IS30 family
smi_1090	COG0210	DNA helicase
smi_1097	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
smi_1101	COG0542	response to heat
smi_1102	COG1396	sequence-specific DNA binding
smi_1104	COG0366	Alpha amylase catalytic
smi_1105	COG1597	lipid kinase activity
smi_1109	COG2814	Major facilitator Superfamily
smi_1119	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
smi_1121	COG0741	lytic transglycosylase activity
smi_1126	COG2890	protein-(glutamine-N5) methyltransferase activity
smi_1127	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
smi_1129	COG1435	thymidine kinase activity
smi_1130	COG1942	4-Oxalocrotonate Tautomerase
smi_1131	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
smi_1133	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
smi_1135	COG4708	membrane
smi_1137	COG1970	mechanosensitive ion channel activity
smi_1139	COG2195	Cleaves the N-terminal amino acid of tripeptides
smi_1140	COG3344	reverse transcriptase
smi_1143	COG0803	Belongs to the bacterial solute-binding protein 9 family
smi_1143	COG3443	Belongs to the bacterial solute-binding protein 9 family
smi_1144	COG0531	amino acid
smi_1145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
smi_1146	COG0785	Cytochrome C biogenesis protein
smi_1149	COG0785	Cytochrome C biogenesis protein
smi_1151	COG1307	EDD domain protein, DegV family
smi_1152	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
smi_1153	COG0196	riboflavin kinase activity
smi_1154	COG0024	Methionine aminopeptidase
smi_1155	COG4109	DRTGG domain
smi_1157	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
smi_1158	COG2826	transposase and inactivated derivatives, IS30 family
smi_1162	COG0560	Phosphoserine phosphatase
smi_1164	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
smi_1166	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
smi_1167	COG2826	transposase and inactivated derivatives, IS30 family
smi_1168	COG1523	belongs to the glycosyl hydrolase 13 family
smi_1172	COG0488	(ABC) transporter
smi_1173	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
smi_1175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
smi_1177	COG0745	RESPONSE REGULATOR receiver
smi_1178	COG1194	a g-specific adenine glycosylase
smi_1179	COG0280	phosphate acetyltransferase
smi_1180	COG0564	pseudouridine synthase activity
smi_1182	COG2357	RelA SpoT domain protein
smi_1184	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
smi_1185	COG1104	cysteine desulfurase activity
smi_1189	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
smi_1194	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
smi_1195	COG4684	Psort location CytoplasmicMembrane, score
smi_1197	COG1827	regulation of RNA biosynthetic process
smi_1198	COG2816	NAD+ diphosphatase activity
smi_1201	COG0556	nucleotide-excision repair
smi_1203	COG0765	amino acid transport
smi_1204	COG1126	abc transporter atp-binding protein
smi_1205	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
smi_1206	COG0552	protein localization to endoplasmic reticulum
smi_1207	COG0561	phosphatase activity
smi_1208	COG0561	phosphatase activity
smi_1209	COG1196	nuclear chromosome segregation
smi_1217	COG0473	3-isopropylmalate dehydrogenase activity
smi_1220	COG3142	Participates in the control of copper homeostasis
smi_1221	COG2832	Protein of unknown function (DUF454)
smi_1222	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
smi_1223	COG0758	DNA mediated transformation
smi_1224	COG4750	Nucleotidyl transferase
smi_1227	COG1063	alcohol dehydrogenase
smi_1230	COG3475	LICD family
smi_1231	COG3475	LICD family
smi_1232	COG1914	H( )-stimulated, divalent metal cation uptake system
smi_1234	COG0505	Belongs to the CarA family
smi_1237	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
smi_1240	COG0488	(ABC) transporter
smi_1242	COG1704	LemA family
smi_1251	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
smi_1252	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
smi_1255	COG1078	dGTPase activity
smi_1266	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
smi_1267	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
smi_1268	COG1605	Chorismate mutase
smi_1268	COG0077	Prephenate dehydratase
smi_1269	COG0716	FMN binding
smi_1270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
smi_1274	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
smi_1275	COG0805	protein transport
smi_1276	COG0672	)-iron permease
smi_1277	COG2837	iron assimilation
smi_1278	COG2822	iron ion transport
smi_1284	COG0584	glycerophosphoryl diester phosphodiesterase
smi_1285	COG2176	DNA-directed DNA polymerase activity
smi_1288	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
smi_1290	COG0494	nUDIX hydrolase
smi_1291	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
smi_1294	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
smi_1298	COG1126	abc transporter atp-binding protein
smi_1301	COG0628	permease
smi_1302	COG4166	transmembrane transport
smi_1303	COG2826	transposase and inactivated derivatives, IS30 family
smi_1304	COG2706	6-phosphogluconolactonase activity
smi_1316	COG0826	peptidase U32
smi_1317	COG3064	Membrane
smi_1323	COG1674	ftsk spoiiie
smi_1324	COG2946	Replication initiation factor
smi_1332	COG0791	NLP P60 protein
smi_1332	COG0741	lytic transglycosylase activity
smi_1341	COG0582	viral genome integration into host DNA
smi_1343	COG2188	Transcriptional regulator
smi_1344	COG0697	spore germination
smi_1345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
smi_1347	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
smi_1354	COG1104	cysteine desulfurase activity
smi_1356	COG1674	ftsk spoiiie
smi_1356	COG0697	spore germination
smi_1357	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
smi_1357	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
smi_1357	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
smi_1358	COG1105	Belongs to the carbohydrate kinase PfkB family
smi_1365	COG2801	Transposase and inactivated derivatives
smi_1375	COG0561	phosphatase activity
smi_1379	COG0492	ferredoxin-NADP+ reductase activity
smi_1381	COG1126	abc transporter atp-binding protein
smi_1383	COG1393	Belongs to the ArsC family
smi_1387	COG1272	protein, Hemolysin III
smi_1393	COG1053	succinate dehydrogenase
smi_1393	COG3976	FMN-binding domain protein
smi_1393	COG0431	NADPH-dependent FMN reductase
smi_1395	COG0751	glycine-tRNA ligase activity
smi_1399	COG0726	polysaccharide deacetylase
smi_1402	COG0513	Belongs to the DEAD box helicase family
smi_1404	COG1263	PTS System
smi_1404	COG2190	(PTS) system
smi_1404	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
smi_1405	COG2826	transposase and inactivated derivatives, IS30 family
smi_1406	COG2177	Part of the ABC transporter FtsEX involved in
smi_1407	COG2884	Cell division ATP-binding protein ftsE
smi_1408	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
smi_1409	COG2826	transposase and inactivated derivatives, IS30 family
smi_1410	COG0517	IMP dehydrogenase activity
smi_1410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
smi_1410	COG0617	tRNA 3'-terminal CCA addition
smi_1418	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
smi_1419	COG2826	transposase and inactivated derivatives, IS30 family
smi_1420	COG2131	deaminase
smi_1422	COG1307	EDD domain protein, DegV family
smi_1423	COG2081	HI0933 family
smi_1425	COG0789	Transcriptional regulator
smi_1426	COG0733	neurotransmitter:sodium symporter activity
smi_1427	COG1482	cell wall glycoprotein biosynthetic process
smi_1429	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
smi_1431	COG0028	Belongs to the TPP enzyme family
smi_1432	COG2217	Heavy metal translocating P-type atpase
smi_1435	COG1304	FMN binding
smi_1437	COG0765	amino acid transport
smi_1438	COG1126	abc transporter atp-binding protein
smi_1439	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
smi_1440	COG1131	(ABC) transporter
smi_1447	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
smi_1450	COG1136	(ABC) transporter
smi_1453	COG1217	gtp-binding protein TYPA
smi_1454	COG1187	pseudouridine synthase activity
smi_1455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
smi_1457	COG2197	response regulator
smi_1460	COG1136	(ABC) transporter
smi_1463	COG0464	growth
smi_1467	COG5263	repeat protein
smi_1467	COG4193	domain, Protein
smi_1471	COG0300	oxidoreductase activity
smi_1473	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
smi_1474	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
smi_1478	COG1940	carbohydrate kinase activity
smi_1481	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
smi_1482	COG3064	Membrane
smi_1484	COG2972	Histidine kinase
smi_1485	COG4753	response regulator
smi_1485	COG2207	Transcriptional regulator
smi_1486	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
smi_1486	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
smi_1487	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
smi_1488	COG0785	Cytochrome C biogenesis protein
smi_1490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
smi_1492	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
smi_1497	COG1113	amino acid transport
smi_1499	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
smi_1504	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
smi_1507	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
smi_1508	COG0626	cystathionine gamma-synthase activity
smi_1510	COG4166	transmembrane transport
smi_1511	COG2244	polysaccharide biosynthetic process
smi_1512	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
smi_1517	COG2827	Endonuclease containing a URI domain
smi_1518	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
smi_1519	COG1098	S1 RNA binding domain
smi_1521	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
smi_1522	COG0629	single-stranded DNA binding
smi_1523	COG0360	Binds together with S18 to 16S ribosomal RNA
smi_1524	COG2826	transposase and inactivated derivatives, IS30 family
smi_1525	COG0017	Asparaginyl-tRNA synthetase
smi_1527	COG0436	Aminotransferase
smi_1532	COG3711	transcriptional antiterminator
smi_1534	COG3250	beta-galactosidase activity
smi_1538	COG0366	Alpha amylase catalytic
smi_1538	COG0366	Alpha amylase catalytic
smi_1542	COG0242	peptide deformylase activity
smi_1544	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
smi_1545	COG0488	(ABC) transporter
smi_1546	COG0617	tRNA 3'-terminal CCA addition
smi_1548	COG1307	EDD domain protein, DegV family
smi_1552	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
smi_1553	COG0492	ferredoxin-NADP+ reductase activity
smi_1555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
smi_1557	COG0251	oxidation-reduction process
smi_1561	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
smi_1565	COG3935	DnaD domain protein
smi_1568	COG2226	methyltransferase
smi_1573	COG1363	Peptidase, m42
smi_1574	COG1114	Component of the transport system for branched-chain amino acids
smi_1576	COG1573	uracil-dna glycosylase
smi_1579	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
smi_1587	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
smi_1587	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
smi_1589	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
smi_1590	COG0765	amino acid transport
smi_1591	COG0765	amino acid transport
smi_1592	COG3842	ATPase activity
smi_1594	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
smi_1595	COG0215	cysteine-tRNA ligase activity
smi_1596	COG0456	acetyltransferase
smi_1597	COG1045	serine acetyltransferase
smi_1600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
smi_1614	COG1940	carbohydrate kinase activity
smi_1615	COG1263	PTS System
smi_1615	COG2190	(PTS) system
smi_1615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
smi_1616	COG1621	beta-fructofuranosidase activity
smi_1617	COG1609	Transcriptional regulator
smi_1619	COG3425	synthase
smi_1622	COG2815	serine threonine protein kinase
smi_1622	COG0515	serine threonine protein kinase
smi_1623	COG0631	protein serine/threonine phosphatase activity
smi_1624	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
smi_1624	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
smi_1626	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
smi_1628	COG0194	GDP metabolic process
smi_1633	COG2226	methyltransferase
smi_1634	COG0799	negative regulation of ribosome biogenesis
smi_1636	COG1713	HD superfamily hydrolase involved in NAD metabolism
smi_1637	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
smi_1638	COG1534	Rna-binding protein
smi_1639	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
smi_1642	COG0668	transmembrane transport
smi_1643	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
smi_1647	COG0438	transferase activity, transferring glycosyl groups
smi_1648	COG0438	transferase activity, transferring glycosyl groups
smi_1649	COG0653	protein targeting
smi_1653	COG0201	protein transport
smi_1654	COG1215	transferase activity, transferring glycosyl groups
smi_1655	COG1442	glycosyl transferase family 8
smi_1656	COG1442	glycosyl transferase family 8
smi_1657	COG1442	glycosyl transferase family 8
smi_1657	COG1216	Glycosyl transferase, family 2
smi_1658	COG1442	glycosyl transferase family 8
smi_1659	COG0438	transferase activity, transferring glycosyl groups
smi_1660	COG1442	glycosyl transferase family 8
smi_1661	COG1216	Glycosyl transferase, family 2
smi_1661	COG1442	glycosyl transferase family 8
smi_1663	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
smi_1675	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
smi_1676	COG0439	Biotin carboxylase
smi_1679	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
smi_1680	COG1028	Short-chain dehydrogenase reductase Sdr
smi_1681	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
smi_1683	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
smi_1686	COG1024	Enoyl-CoA hydratase
smi_1687	COG0527	aspartate kinase activity
smi_1695	COG0791	NLP P60 protein
smi_1695	COG0741	lytic transglycosylase activity
smi_1697	COG2207	Transcriptional regulator
smi_1697	COG3708	Transcriptional regulator
smi_1698	COG1132	(ABC) transporter
smi_1698	COG2375	cellular response to nickel ion
smi_1705	COG0456	acetyltransferase
smi_1707	COG2378	regulation of single-species biofilm formation
smi_1709	COG0456	acetyltransferase
smi_1711	COG2226	methyltransferase
smi_1713	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
smi_1718	COG1131	(ABC) transporter
smi_1722	COG1115	amino acid carrier protein
smi_1724	COG5263	repeat protein
smi_1724	COG4193	domain, Protein
smi_1725	COG4193	domain, Protein
smi_1725	COG5263	repeat protein
smi_1728	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
smi_1730	COG0443	Heat shock 70 kDa protein
smi_1737	COG0681	Belongs to the peptidase S26 family
smi_1738	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
smi_1741	COG2197	response regulator
smi_1742	COG4585	Histidine kinase
smi_1749	COG0745	RESPONSE REGULATOR receiver
smi_1750	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
smi_1752	COG0116	Belongs to the methyltransferase superfamily
smi_1757	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
smi_1758	COG4166	transmembrane transport
smi_1759	COG0562	UDP-galactopyranose mutase
smi_1761	COG0366	Alpha amylase catalytic
smi_1764	COG3344	reverse transcriptase
smi_1767	COG0768	penicillin binding
smi_1768	COG4839	cell division protein FtsL
smi_1774	COG0386	Belongs to the glutathione peroxidase family
smi_1777	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
smi_1778	COG3620	sequence-specific DNA binding
smi_1779	COG3104	oligopeptide transport
smi_1780	COG1373	ATPase (AAA superfamily
smi_1784	COG0477	Major facilitator Superfamily
smi_1789	COG1674	ftsk spoiiie
smi_1796	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
smi_1797	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
smi_1798	COG2826	transposase and inactivated derivatives, IS30 family
smi_1799	COG1668	transmembrane transport
smi_1800	COG4152	abc transporter atp-binding protein
smi_1801	COG0072	phenylalanine-tRNA ligase activity
smi_1801	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
smi_1806	COG0671	phosphoesterase, PA-phosphatase related
smi_1807	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
smi_1810	COG1122	ATPase activity
smi_1813	COG0569	domain protein
smi_1814	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
smi_1815	COG1882	Formate acetyltransferase
smi_1816	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
smi_1819	COG0765	amino acid transport
smi_1822	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
smi_1824	COG0440	acetolactate synthase activity
smi_1825	COG0028	Belongs to the TPP enzyme family
smi_1826	COG1461	Dihydroxyacetone kinase
smi_1828	COG0227	Belongs to the bacterial ribosomal protein bL28 family
smi_1829	COG2826	transposase and inactivated derivatives, IS30 family
smi_1830	COG2826	transposase and inactivated derivatives, IS30 family
smi_1834	COG1132	(ABC) transporter
smi_1841	COG1316	TRANSCRIPTIONal
smi_1843	COG0802	atpase or kinase
smi_1848	COG1523	belongs to the glycosyl hydrolase 13 family
smi_1850	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
smi_1851	COG2723	6-phospho-beta-galactosidase activity
smi_1853	COG0750	zinc metalloprotease
smi_1854	COG4589	Belongs to the CDS family
smi_1855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
smi_1856	COG2826	transposase and inactivated derivatives, IS30 family
smi_1869	COG3279	Response regulator of the LytR AlgR family
smi_1876	COG2848	UPF0210 protein
smi_1877	COG3830	Belongs to the UPF0237 family
smi_1879	COG0202	RNA polymerase activity
smi_1880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
smi_1882	COG0257	Belongs to the bacterial ribosomal protein bL36 family
smi_1883	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
smi_1885	COG0201	protein transport
smi_1888	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
smi_1892	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
smi_1896	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
smi_1901	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
smi_1902	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
smi_1907	COG2826	transposase and inactivated derivatives, IS30 family
smi_1909	COG0602	queuosine metabolic process
smi_1915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
smi_1917	COG0285	dihydrofolate synthase activity
smi_1922	COG1393	Belongs to the ArsC family
smi_1923	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
smi_1924	COG0006	proline dipeptidase activity
smi_1925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
smi_1929	COG2818	Glycosylase
smi_1935	COG1780	Probably involved in ribonucleotide reductase function
smi_1937	COG4753	response regulator
smi_1937	COG2207	Transcriptional regulator
smi_1938	COG2972	Histidine kinase
smi_1942	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
smi_1943	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
smi_1944	COG1464	Belongs to the NlpA lipoprotein family
smi_1945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
smi_1946	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
smi_1950	COG1396	sequence-specific DNA binding
smi_1951	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
smi_1953	COG1214	PFAM Peptidase M22, glycoprotease
smi_1954	COG2826	transposase and inactivated derivatives, IS30 family
smi_1961	COG0445	tRNA wobble uridine modification
smi_1962	COG0494	nUDIX hydrolase
smi_1964	COG2826	transposase and inactivated derivatives, IS30 family
smi_1968	COG0137	argininosuccinate synthase activity
smi_1969	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
smi_1973	COG1131	(ABC) transporter
smi_1978	COG1705	Flagellar rod assembly protein muramidase FlgJ
smi_1978	COG1388	LysM domain
smi_1979	COG1760	l-serine dehydratase
smi_1980	COG1760	l-serine dehydratase
smi_1983	COG1216	Glycosyl transferase, family 2
smi_1985	COG1695	Transcriptional regulator
smi_1993	COG1653	transport
smi_1994	COG0395	ABC-type sugar transport system, permease component
smi_1995	COG4209	transmembrane transport
smi_1998	COG0383	alpha-mannosidase activity
smi_2017	COG0582	viral genome integration into host DNA
smi_2018	COG3537	Alpha-1,2-mannosidase
smi_2021	COG3250	beta-galactosidase activity
smi_2023	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
smi_2024	COG0803	Belongs to the bacterial solute-binding protein 9 family
smi_2024	COG3443	Belongs to the bacterial solute-binding protein 9 family
smi_2025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
smi_2026	COG1121	(ABC) transporter
smi_2027	COG1846	Transcriptional regulator
smi_2028	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
smi_2030	COG1696	Membrane protein involved in D-alanine export
smi_2032	COG2211	Major facilitator Superfamily
smi_2033	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
smi_2034	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
smi_2038	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
smi_2043	COG3201	nicotinamide mononucleotide transporter
smi_2045	COG0542	response to heat
smi_2046	COG4463	regulation of RNA biosynthetic process
smi_2047	COG1116	anion transmembrane transporter activity
smi_2048	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
smi_2049	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
smi_2053	COG0305	Participates in initiation and elongation during chromosome replication
smi_2057	COG1040	competence protein
smi_2058	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
smi_2059	COG1739	Uncharacterized protein family UPF0029
smi_2063	COG3942	CHAP domain
smi_2065	COG1792	Involved in formation and maintenance of cell shape
smi_2066	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
smi_2067	COG1122	ATPase activity
smi_2068	COG1122	ATPase activity
smi_2069	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
smi_2071	COG0612	Peptidase, M16
smi_2072	COG0612	Peptidase, M16
smi_2073	COG2501	S4 domain
smi_2075	COG0516	GMP reductase activity
smi_2075	COG0517	IMP dehydrogenase activity
smi_2076	COG0180	Tryptophanyl-tRNA synthetase
smi_2077	COG0488	(ABC) transporter
smi_2079	COG1511	domain protein
smi_2079	COG1511	domain protein
smi_2088	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
smi_2089	COG1475	DNA binding