locus-tag	class	description
SM12261_RS00010	COG0592	DNA-directed DNA polymerase activity
SM12261_RS00020	COG0012	GTP binding
SM12261_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SM12261_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SM12261_RS00055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SM12261_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SM12261_RS00120	COG0756	dUTP diphosphatase activity
SM12261_RS00130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SM12261_RS00145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SM12261_RS00190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SM12261_RS00190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SM12261_RS00195	COG1832	CoA-binding protein
SM12261_RS00205	COG2855	membrane
SM12261_RS00210	COG0436	Aminotransferase
SM12261_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SM12261_RS00275	COG2274	protein secretion by the type I secretion system
SM12261_RS00280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
SM12261_RS00295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SM12261_RS00300	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SM12261_RS00305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SM12261_RS00310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SM12261_RS00315	COG0138	bifunctional purine biosynthesis protein purh
SM12261_RS00320	COG0151	Belongs to the GarS family
SM12261_RS00330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SM12261_RS00345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SM12261_RS00360	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SM12261_RS00365	COG3715	PTS system
SM12261_RS00370	COG3716	PTS system mannose fructose sorbose family IID component
SM12261_RS00380	COG2222	sugar isomerase
SM12261_RS00400	COG3583	domain protein
SM12261_RS00410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SM12261_RS00430	COG2514	catechol 2,3-dioxygenase activity
SM12261_RS00435	COG0110	maltose O-acetyltransferase activity
SM12261_RS00445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SM12261_RS00450	COG0569	domain protein
SM12261_RS00455	COG1215	transferase activity, transferring glycosyl groups
SM12261_RS00470	COG5002	protein histidine kinase activity
SM12261_RS00490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SM12261_RS00515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SM12261_RS00530	COG3959	Transketolase, thiamine diphosphate binding domain
SM12261_RS00535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SM12261_RS00550	COG2151	metal-sulfur cluster biosynthetic enzyme
SM12261_RS00585	COG1476	TRANSCRIPTIONal
SM12261_RS00615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SM12261_RS00620	COG1609	Transcriptional regulator
SM12261_RS00625	COG5521	maltodextrose utilization protein MalA
SM12261_RS00630	COG3833	ABC-type maltose transport systems, permease component
SM12261_RS00635	COG1175	transmembrane transport
SM12261_RS00640	COG2182	Extracellular solute-binding protein
SM12261_RS00645	COG1640	4-alpha-glucanotransferase
SM12261_RS00650	COG0058	SHG alpha-glucan phosphorylase activity
SM12261_RS00665	COG2226	methyltransferase
SM12261_RS00680	COG2217	Heavy metal translocating P-type atpase
SM12261_RS00690	COG4499	WXG100 protein secretion system (Wss), protein YukC
SM12261_RS00690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SM12261_RS00695	COG0697	spore germination
SM12261_RS00710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SM12261_RS00720	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SM12261_RS00740	COG1438	arginine binding
SM12261_RS00750	COG1132	(ABC) transporter
SM12261_RS00755	COG1132	(ABC) transporter
SM12261_RS00760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SM12261_RS00770	COG0166	Belongs to the GPI family
SM12261_RS00880	COG0534	Mate efflux family protein
SM12261_RS00910	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SM12261_RS00935	COG1063	alcohol dehydrogenase
SM12261_RS00945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SM12261_RS00950	COG1459	type II secretion system
SM12261_RS00955	COG4537	Required for transformation and DNA binding
SM12261_RS01000	COG0706	membrane insertase activity
SM12261_RS01015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SM12261_RS01025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SM12261_RS01035	COG1012	belongs to the aldehyde dehydrogenase family
SM12261_RS01035	COG1454	alcohol dehydrogenase
SM12261_RS01050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SM12261_RS01055	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SM12261_RS01160	COG1131	(ABC) transporter
SM12261_RS01165	COG0842	Transport permease protein
SM12261_RS01170	COG4585	Histidine kinase
SM12261_RS01175	COG2197	response regulator
SM12261_RS01200	COG2176	DNA-directed DNA polymerase activity
SM12261_RS01210	COG2309	aminopeptidase activity
SM12261_RS01215	COG2261	transglycosylase associated protein
SM12261_RS01225	COG1187	pseudouridine synthase activity
SM12261_RS01260	COG3716	PTS system mannose fructose sorbose family IID component
SM12261_RS01265	COG3715	PTS system
SM12261_RS01275	COG1064	alcohol dehydrogenase
SM12261_RS01280	COG0561	phosphatase activity
SM12261_RS01285	COG2252	PERMEase
SM12261_RS01295	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SM12261_RS01300	COG0285	dihydrofolate synthase activity
SM12261_RS01310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SM12261_RS01310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SM12261_RS01320	COG1609	Transcriptional regulator
SM12261_RS01325	COG0252	asparaginase activity
SM12261_RS01330	COG0561	phosphatase activity
SM12261_RS01335	COG0589	response to stress
SM12261_RS01345	COG0436	Aminotransferase
SM12261_RS01355	COG4166	transmembrane transport
SM12261_RS01365	COG0531	amino acid
SM12261_RS01375	COG0084	hydrolase, TatD family'
SM12261_RS01390	COG1162	GTPase activity
SM12261_RS01400	COG1564	THIamine pyrophosphokinase
SM12261_RS01410	COG3481	metal-dependent phosphohydrolase, HD sub domain
SM12261_RS01415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SM12261_RS01425	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SM12261_RS01435	COG1254	Belongs to the acylphosphatase family
SM12261_RS01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SM12261_RS01460	COG0742	ribosomal rna small subunit methyltransferase
SM12261_RS01470	COG3480	Lon protease (S16) C-terminal proteolytic domain
SM12261_RS01480	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SM12261_RS01500	COG1253	flavin adenine dinucleotide binding
SM12261_RS01510	COG4166	transmembrane transport
SM12261_RS01515	COG0601	transmembrane transport
SM12261_RS01520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SM12261_RS01525	COG0444	Belongs to the ABC transporter superfamily
SM12261_RS01530	COG4608	Belongs to the ABC transporter superfamily
SM12261_RS01540	COG0583	DNA-binding transcription factor activity
SM12261_RS01550	COG0281	malic enzyme
SM12261_RS01570	COG4120	Belongs to the binding-protein-dependent transport system permease family
SM12261_RS01575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SM12261_RS01590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SM12261_RS01620	COG1187	pseudouridine synthase activity
SM12261_RS01630	COG4607	ABC-type enterochelin transport system periplasmic component
SM12261_RS01635	COG4604	ABC transporter, ATP-binding protein
SM12261_RS01640	COG4605	iron ion homeostasis
SM12261_RS01645	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SM12261_RS01650	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SM12261_RS01655	COG1363	Peptidase, m42
SM12261_RS01685	COG0789	Transcriptional regulator
SM12261_RS01690	COG0174	glutamine synthetase
SM12261_RS01715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SM12261_RS01740	COG0484	heat shock protein binding
SM12261_RS01750	COG0537	adenosine 5'-monophosphoramidase activity
SM12261_RS01755	COG1131	(ABC) transporter
SM12261_RS01760	COG4473	ABC transporter
SM12261_RS01820	COG1266	CAAX protease self-immunity
SM12261_RS01845	COG0195	Participates in both transcription termination and antitermination
SM12261_RS01850	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SM12261_RS01900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SM12261_RS01910	COG0525	valine-tRNA ligase activity
SM12261_RS01920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SM12261_RS01945	COG0504	CTP synthase activity
SM12261_RS01965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SM12261_RS01970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SM12261_RS01975	COG4221	oxidoreductase activity
SM12261_RS02010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SM12261_RS02130	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SM12261_RS02130	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SM12261_RS02135	COG2207	Transcriptional regulator
SM12261_RS02140	COG3345	alpha-galactosidase
SM12261_RS02145	COG1653	transport
SM12261_RS02150	COG1175	transmembrane transport
SM12261_RS02155	COG0395	ABC-type sugar transport system, permease component
SM12261_RS02165	COG0366	Alpha amylase catalytic
SM12261_RS02175	COG1846	Transcriptional regulator
SM12261_RS02185	COG1125	glycine betaine transport
SM12261_RS02185	COG0517	IMP dehydrogenase activity
SM12261_RS02190	COG1174	glycine betaine transport
SM12261_RS02200	COG1230	cation diffusion facilitator family transporter
SM12261_RS02205	COG0789	Transcriptional regulator
SM12261_RS02210	COG1063	alcohol dehydrogenase
SM12261_RS02215	COG1609	Transcriptional regulator
SM12261_RS02220	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SM12261_RS02225	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SM12261_RS02235	COG2233	PERMEase
SM12261_RS02255	COG0708	Exodeoxyribonuclease III
SM12261_RS02270	COG1132	(ABC) transporter
SM12261_RS02275	COG1132	(ABC) transporter
SM12261_RS02280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SM12261_RS02290	COG0133	tryptophan synthase activity
SM12261_RS02295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SM12261_RS02300	COG0512	Glutamine amidotransferase of anthranilate synthase
SM12261_RS02315	COG0135	phosphoribosylanthranilate isomerase activity
SM12261_RS02330	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SM12261_RS02345	COG3237	CsbD-like
SM12261_RS02375	COG1609	Transcriptional regulator
SM12261_RS02385	COG1175	transmembrane transport
SM12261_RS02390	COG0395	ABC-type sugar transport system, permease component
SM12261_RS02395	COG1621	beta-fructofuranosidase activity
SM12261_RS02405	COG0596	Alpha beta hydrolase
SM12261_RS02410	COG0604	alcohol dehydrogenase
SM12261_RS02410	COG1028	Short-chain dehydrogenase reductase Sdr
SM12261_RS02410	COG3321	synthase
SM12261_RS02415	COG1959	2 iron, 2 sulfur cluster binding
SM12261_RS02465	COG1051	belongs to the nudix hydrolase family
SM12261_RS02470	COG2264	protein methyltransferase activity
SM12261_RS02475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SM12261_RS02480	COG1164	Oligoendopeptidase f
SM12261_RS02490	COG1733	regulation of RNA biosynthetic process
SM12261_RS02505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SM12261_RS02525	COG0720	synthase
SM12261_RS02535	COG3118	belongs to the thioredoxin family
SM12261_RS02555	COG1346	cytolysis
SM12261_RS02590	COG1131	(ABC) transporter
SM12261_RS02595	COG1725	Transcriptional regulator
SM12261_RS02610	COG1484	DNA-dependent DNA replication
SM12261_RS02645	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SM12261_RS02650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SM12261_RS02665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SM12261_RS02675	COG3458	cephalosporin-C deacetylase activity
SM12261_RS02685	COG1263	PTS System
SM12261_RS02685	COG2190	(PTS) system
SM12261_RS02685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SM12261_RS02695	COG1175	transmembrane transport
SM12261_RS02700	COG0395	ABC-type sugar transport system, permease component
SM12261_RS02705	COG2731	YhcH YjgK YiaL family protein
SM12261_RS02715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SM12261_RS02740	COG0768	penicillin binding
SM12261_RS02755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SM12261_RS02775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SM12261_RS02795	COG3599	regulation of cell shape
SM12261_RS02825	COG0577	efflux transmembrane transporter activity
SM12261_RS02825	COG1136	(ABC) transporter
SM12261_RS02835	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SM12261_RS02865	COG0860	N-Acetylmuramoyl-L-alanine amidase
SM12261_RS02865	COG2247	cell wall binding repeat
SM12261_RS02910	COG1959	2 iron, 2 sulfur cluster binding
SM12261_RS02925	COG0745	RESPONSE REGULATOR receiver
SM12261_RS02930	COG5002	protein histidine kinase activity
SM12261_RS02940	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
SM12261_RS02990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SM12261_RS02995	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SM12261_RS03010	COG0204	Acyl-transferase
SM12261_RS03015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SM12261_RS03020	COG2384	SAM-dependent methyltransferase
SM12261_RS03025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SM12261_RS03030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SM12261_RS03040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SM12261_RS03045	COG0463	Glycosyl transferase, family 2
SM12261_RS03065	COG2824	Alkylphosphonate utilization operon protein PhnA
SM12261_RS03085	COG0351	phosphomethylpyrimidine kinase
SM12261_RS03090	COG4720	Psort location CytoplasmicMembrane, score
SM12261_RS03095	COG0006	proline dipeptidase activity
SM12261_RS03100	COG3442	glutamine amidotransferase
SM12261_RS03105	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SM12261_RS03110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SM12261_RS03115	COG0513	Belongs to the DEAD box helicase family
SM12261_RS03125	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SM12261_RS03140	COG0577	efflux transmembrane transporter activity
SM12261_RS03145	COG1136	(ABC) transporter
SM12261_RS03150	COG0577	efflux transmembrane transporter activity
SM12261_RS03155	COG0745	RESPONSE REGULATOR receiver
SM12261_RS03160	COG5002	protein histidine kinase activity
SM12261_RS03165	COG0191	fructose-bisphosphate aldolase activity
SM12261_RS03170	COG4555	ABC transporter
SM12261_RS03195	COG3250	beta-galactosidase activity
SM12261_RS03205	COG1242	4 iron, 4 sulfur cluster binding
SM12261_RS03210	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SM12261_RS03220	COG0025	NhaP-type Na H and K H
SM12261_RS03245	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SM12261_RS03250	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SM12261_RS03270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SM12261_RS03280	COG0647	UMP catabolic process
SM12261_RS03290	COG1393	Belongs to the ArsC family
SM12261_RS03300	COG0483	inositol monophosphate 1-phosphatase activity
SM12261_RS03305	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SM12261_RS03305	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SM12261_RS03310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SM12261_RS03315	COG0573	inorganic phosphate transmembrane transporter activity
SM12261_RS03320	COG0581	inorganic phosphate transmembrane transporter activity
SM12261_RS03325	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SM12261_RS03330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SM12261_RS03335	COG0704	Plays a role in the regulation of phosphate uptake
SM12261_RS03340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SM12261_RS03350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SM12261_RS03355	COG3527	Alpha-acetolactate decarboxylase
SM12261_RS03370	COG3842	ATPase activity
SM12261_RS03375	COG1177	transmembrane transport
SM12261_RS03390	COG1002	Type II restriction enzyme, methylase subunits
SM12261_RS03395	COG1061	Type III restriction enzyme res subunit
SM12261_RS03400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SM12261_RS03425	COG4555	ABC transporter
SM12261_RS03435	COG1368	sulfuric ester hydrolase activity
SM12261_RS03440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SM12261_RS03465	COG0287	Prephenate dehydrogenase
SM12261_RS03480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SM12261_RS03485	COG0077	Prephenate dehydratase
SM12261_RS03495	COG3475	LICD family
SM12261_RS03505	COG1215	transferase activity, transferring glycosyl groups
SM12261_RS03535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SM12261_RS03535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SM12261_RS03540	COG1132	(ABC) transporter
SM12261_RS03545	COG1132	(ABC) transporter
SM12261_RS03550	COG0402	S-adenosylhomocysteine deaminase activity
SM12261_RS03560	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SM12261_RS03570	COG1396	sequence-specific DNA binding
SM12261_RS03575	COG0542	response to heat
SM12261_RS03590	COG2946	Replication initiation factor
SM12261_RS03600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SM12261_RS03630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SM12261_RS03655	COG3843	relaxase mobilization nuclease domain protein
SM12261_RS03670	COG1132	(ABC) transporter
SM12261_RS03680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SM12261_RS03685	COG0167	dihydroorotate dehydrogenase activity
SM12261_RS03700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SM12261_RS03705	COG4470	Protein conserved in bacteria
SM12261_RS03710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SM12261_RS03720	COG0488	(ABC) transporter
SM12261_RS03770	COG1328	CTP reductase activity
SM12261_RS03770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SM12261_RS03780	COG4443	Transcriptional Coactivator p15 (PC4)
SM12261_RS03785	COG1268	BioY protein
SM12261_RS03800	COG1136	(ABC) transporter
SM12261_RS03805	COG0577	efflux transmembrane transporter activity
SM12261_RS03810	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SM12261_RS03810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SM12261_RS03825	COG4989	oxidoreductase activity
SM12261_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
SM12261_RS03850	COG0745	RESPONSE REGULATOR receiver
SM12261_RS03855	COG5002	protein histidine kinase activity
SM12261_RS03875	COG0772	Belongs to the SEDS family
SM12261_RS03880	COG0693	protein deglycase activity
SM12261_RS03890	COG0187	DNA topoisomerase II activity
SM12261_RS03895	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SM12261_RS03925	COG0542	response to heat
SM12261_RS03935	COG4703	Protein of unknown function (DUF1797)
SM12261_RS03940	COG0765	amino acid transport
SM12261_RS03945	COG1126	abc transporter atp-binding protein
SM12261_RS03950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SM12261_RS03960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SM12261_RS03985	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SM12261_RS03995	COG0813	purine-nucleoside phosphorylase activity
SM12261_RS04025	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SM12261_RS04035	COG0295	cytidine deaminase activity
SM12261_RS04040	COG1744	ABC transporter substrate-binding protein PnrA-like
SM12261_RS04045	COG3845	ABC transporter
SM12261_RS04050	COG4603	Belongs to the binding-protein-dependent transport system permease family
SM12261_RS04055	COG1079	Belongs to the binding-protein-dependent transport system permease family
SM12261_RS04065	COG0187	DNA topoisomerase II activity
SM12261_RS04075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SM12261_RS04080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SM12261_RS04085	COG4166	transmembrane transport
SM12261_RS04105	COG0539	negative regulation of cytoplasmic translation
SM12261_RS04110	COG1956	GAF domain-containing protein
SM12261_RS04115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SM12261_RS04130	COG0719	Fe-S assembly protein
SM12261_RS04135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SM12261_RS04145	COG0719	Fe-S assembly protein
SM12261_RS04150	COG1686	Belongs to the peptidase S11 family
SM12261_RS04155	COG0628	permease
SM12261_RS04200	COG0583	DNA-binding transcription factor activity
SM12261_RS04205	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SM12261_RS04210	COG0564	pseudouridine synthase activity
SM12261_RS04215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SM12261_RS04230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SM12261_RS04240	COG0470	DNA polymerase III
SM12261_RS04265	COG0528	UMP kinase activity
SM12261_RS04275	COG2996	Protein conserved in bacteria
SM12261_RS04285	COG1702	phosphate starvation-inducible protein PhoH
SM12261_RS04290	COG0686	Belongs to the AlaDH PNT family
SM12261_RS04295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SM12261_RS04300	COG1596	polysaccharide export
SM12261_RS04300	COG1555	photosystem II stabilization
SM12261_RS04305	COG2333	competence protein COMEC
SM12261_RS04305	COG0658	competence protein
SM12261_RS04325	COG0443	Heat shock 70 kDa protein
SM12261_RS04330	COG2214	Heat shock protein DnaJ domain protein
SM12261_RS04340	COG0543	2 iron, 2 sulfur cluster binding
SM12261_RS04345	COG0167	dihydroorotate dehydrogenase activity
SM12261_RS04350	COG5263	repeat protein
SM12261_RS04350	COG4193	domain, Protein
SM12261_RS04355	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SM12261_RS04365	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SM12261_RS04375	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SM12261_RS04380	COG0237	dephospho-CoA kinase activity
SM12261_RS04385	COG2814	Major facilitator Superfamily
SM12261_RS04390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SM12261_RS04400	COG0557	exoribonuclease II activity
SM12261_RS04410	COG0500	methyltransferase
SM12261_RS04410	COG3615	Tellurite resistance protein tehB
SM12261_RS04425	COG4122	O-methyltransferase activity
SM12261_RS04435	COG0772	Belongs to the SEDS family
SM12261_RS04440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SM12261_RS04460	COG0358	DNA primase activity
SM12261_RS04465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SM12261_RS04470	COG2151	metal-sulfur cluster biosynthetic enzyme
SM12261_RS04475	COG0438	transferase activity, transferring glycosyl groups
SM12261_RS04480	COG0438	transferase activity, transferring glycosyl groups
SM12261_RS04485	COG1983	PspC domain protein
SM12261_RS04505	COG1438	arginine binding
SM12261_RS04510	COG2936	dipeptidyl-peptidase activity
SM12261_RS04530	COG0469	pyruvate kinase activity
SM12261_RS04540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SM12261_RS04545	COG3764	Sortase (surface protein transpeptidase)
SM12261_RS04575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SM12261_RS04600	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SM12261_RS04605	COG1438	arginine binding
SM12261_RS04610	COG0497	DNA recombination
SM12261_RS04615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SM12261_RS04635	COG3775	system Galactitol-specific IIC component
SM12261_RS04660	COG3684	Belongs to the aldolase LacD family
SM12261_RS04665	COG3711	transcriptional antiterminator
SM12261_RS04680	COG2723	6-phospho-beta-galactosidase activity
SM12261_RS04695	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SM12261_RS04700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SM12261_RS04705	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SM12261_RS04710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SM12261_RS04730	COG2376	Dihydroxyacetone kinase
SM12261_RS04735	COG1309	transcriptional regulator
SM12261_RS04740	COG2376	Dihydroxyacetone kinase
SM12261_RS04745	COG1461	Dihydroxyacetone kinase
SM12261_RS04750	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SM12261_RS04770	COG1011	Hydrolase
SM12261_RS04780	COG1051	belongs to the nudix hydrolase family
SM12261_RS04785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SM12261_RS04790	COG0534	Mate efflux family protein
SM12261_RS04795	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SM12261_RS04800	COG0022	dehydrogenase e1 component
SM12261_RS04805	COG0508	dehydrogenase complex catalyzes the overall conversion of
SM12261_RS04810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SM12261_RS04815	COG0095	Lipoate-protein ligase
SM12261_RS04830	COG0038	chloride channel
SM12261_RS04840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SM12261_RS04860	COG0561	phosphatase activity
SM12261_RS04865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SM12261_RS04885	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SM12261_RS04890	COG1982	Orn Lys Arg decarboxylase major
SM12261_RS04900	COG0577	efflux transmembrane transporter activity
SM12261_RS04905	COG1136	(ABC) transporter
SM12261_RS04915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SM12261_RS04930	COG2183	response to ionizing radiation
SM12261_RS04950	COG0701	Predicted permease
SM12261_RS04955	COG3689	TIGRFAM TIGR03943 family protein
SM12261_RS04970	COG0366	Alpha amylase catalytic
SM12261_RS04980	COG1597	lipid kinase activity
SM12261_RS05030	COG0741	lytic transglycosylase activity
SM12261_RS05055	COG2890	protein-(glutamine-N5) methyltransferase activity
SM12261_RS05065	COG1435	thymidine kinase activity
SM12261_RS05070	COG1942	4-Oxalocrotonate Tautomerase
SM12261_RS05075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SM12261_RS05085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SM12261_RS05095	COG4708	membrane
SM12261_RS05105	COG1970	mechanosensitive ion channel activity
SM12261_RS05110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SM12261_RS05115	COG2195	Cleaves the N-terminal amino acid of tripeptides
SM12261_RS05130	COG0803	Belongs to the bacterial solute-binding protein 9 family
SM12261_RS05130	COG3443	Belongs to the bacterial solute-binding protein 9 family
SM12261_RS05135	COG0531	amino acid
SM12261_RS05140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SM12261_RS05145	COG0785	Cytochrome C biogenesis protein
SM12261_RS05155	COG1307	EDD domain protein, DegV family
SM12261_RS05160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SM12261_RS05170	COG0024	Methionine aminopeptidase
SM12261_RS05175	COG4109	DRTGG domain
SM12261_RS05185	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SM12261_RS05210	COG0560	Phosphoserine phosphatase
SM12261_RS05220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SM12261_RS05230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SM12261_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
SM12261_RS05240	COG1523	belongs to the glycosyl hydrolase 13 family
SM12261_RS05260	COG0488	(ABC) transporter
SM12261_RS05265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SM12261_RS05275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SM12261_RS05290	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SM12261_RS05300	COG0745	RESPONSE REGULATOR receiver
SM12261_RS05305	COG1194	a g-specific adenine glycosylase
SM12261_RS05315	COG0280	phosphate acetyltransferase
SM12261_RS05320	COG0564	pseudouridine synthase activity
SM12261_RS05330	COG2357	RelA SpoT domain protein
SM12261_RS05340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SM12261_RS05345	COG1104	cysteine desulfurase activity
SM12261_RS05365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SM12261_RS05390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SM12261_RS05395	COG4684	Psort location CytoplasmicMembrane, score
SM12261_RS05405	COG1827	regulation of RNA biosynthetic process
SM12261_RS05415	COG1879	ABC-type sugar transport system periplasmic component
SM12261_RS05420	COG1172	Belongs to the binding-protein-dependent transport system permease family
SM12261_RS05430	COG1869	D-ribose catabolic process
SM12261_RS05435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SM12261_RS05440	COG1609	Transcriptional regulator
SM12261_RS05455	COG0556	nucleotide-excision repair
SM12261_RS05465	COG0765	amino acid transport
SM12261_RS05470	COG1126	abc transporter atp-binding protein
SM12261_RS05475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SM12261_RS05480	COG0552	protein localization to endoplasmic reticulum
SM12261_RS05485	COG0561	phosphatase activity
SM12261_RS05490	COG0561	phosphatase activity
SM12261_RS05495	COG1196	nuclear chromosome segregation
SM12261_RS05535	COG0473	3-isopropylmalate dehydrogenase activity
SM12261_RS05550	COG3142	Participates in the control of copper homeostasis
SM12261_RS05555	COG2832	Protein of unknown function (DUF454)
SM12261_RS05560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SM12261_RS05565	COG0758	DNA mediated transformation
SM12261_RS05570	COG4750	Nucleotidyl transferase
SM12261_RS05585	COG1063	alcohol dehydrogenase
SM12261_RS05600	COG3475	LICD family
SM12261_RS05605	COG3475	LICD family
SM12261_RS05615	COG0505	Belongs to the CarA family
SM12261_RS05630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SM12261_RS05645	COG0488	(ABC) transporter
SM12261_RS05655	COG1704	LemA family
SM12261_RS05675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SM12261_RS05690	COG1078	dGTPase activity
SM12261_RS05735	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SM12261_RS05740	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SM12261_RS05745	COG1605	Chorismate mutase
SM12261_RS05745	COG0077	Prephenate dehydratase
SM12261_RS05750	COG0716	FMN binding
SM12261_RS05755	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SM12261_RS05780	COG0584	glycerophosphoryl diester phosphodiesterase
SM12261_RS05785	COG2176	DNA-directed DNA polymerase activity
SM12261_RS05795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SM12261_RS05805	COG0494	nUDIX hydrolase
SM12261_RS05810	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SM12261_RS05825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SM12261_RS05845	COG1126	abc transporter atp-binding protein
SM12261_RS05860	COG0628	permease
SM12261_RS05865	COG2706	6-phosphogluconolactonase activity
SM12261_RS05900	COG0356	it plays a direct role in the translocation of protons across the membrane
SM12261_RS05910	COG0826	peptidase U32
SM12261_RS05930	COG2188	Transcriptional regulator
SM12261_RS05935	COG0697	spore germination
SM12261_RS05940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SM12261_RS05950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SM12261_RS05975	COG1104	cysteine desulfurase activity
SM12261_RS05985	COG1674	ftsk spoiiie
SM12261_RS05985	COG0697	spore germination
SM12261_RS05990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SM12261_RS05990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SM12261_RS05990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SM12261_RS05995	COG1105	Belongs to the carbohydrate kinase PfkB family
SM12261_RS06000	COG1349	DNA-binding transcription factor activity
SM12261_RS06015	COG1914	H( )-stimulated, divalent metal cation uptake system
SM12261_RS06030	COG0561	phosphatase activity
SM12261_RS06050	COG0492	ferredoxin-NADP+ reductase activity
SM12261_RS06060	COG1126	abc transporter atp-binding protein
SM12261_RS06065	COG0765	amino acid transport
SM12261_RS06070	COG1393	Belongs to the ArsC family
SM12261_RS06090	COG1272	protein, Hemolysin III
SM12261_RS06120	COG0431	NADPH-dependent FMN reductase
SM12261_RS06120	COG3976	FMN-binding domain protein
SM12261_RS06120	COG1053	succinate dehydrogenase
SM12261_RS06145	COG0656	L-ascorbic acid biosynthetic process
SM12261_RS06150	COG0726	polysaccharide deacetylase
SM12261_RS06210	COG0513	Belongs to the DEAD box helicase family
SM12261_RS06220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SM12261_RS06220	COG1263	PTS System
SM12261_RS06220	COG2190	(PTS) system
SM12261_RS06225	COG2177	Part of the ABC transporter FtsEX involved in
SM12261_RS06230	COG2884	Cell division ATP-binding protein ftsE
SM12261_RS06245	COG0617	tRNA 3'-terminal CCA addition
SM12261_RS06245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SM12261_RS06245	COG0517	IMP dehydrogenase activity
SM12261_RS06290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SM12261_RS06295	COG2131	deaminase
SM12261_RS06305	COG1307	EDD domain protein, DegV family
SM12261_RS06310	COG2081	HI0933 family
SM12261_RS06320	COG0789	Transcriptional regulator
SM12261_RS06330	COG0733	neurotransmitter:sodium symporter activity
SM12261_RS06335	COG1482	cell wall glycoprotein biosynthetic process
SM12261_RS06340	COG2723	6-phospho-beta-galactosidase activity
SM12261_RS06360	COG0028	Belongs to the TPP enzyme family
SM12261_RS06365	COG2217	Heavy metal translocating P-type atpase
SM12261_RS06385	COG0352	thiamine-phosphate diphosphorylase activity
SM12261_RS06400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SM12261_RS06410	COG4172	Belongs to the ABC transporter superfamily
SM12261_RS06420	COG0352	thiamine-phosphate diphosphorylase activity
SM12261_RS06435	COG1304	FMN binding
SM12261_RS06455	COG1335	isochorismatase
SM12261_RS06470	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SM12261_RS06490	COG1217	gtp-binding protein TYPA
SM12261_RS06495	COG1187	pseudouridine synthase activity
SM12261_RS06505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SM12261_RS06520	COG2197	response regulator
SM12261_RS06535	COG1136	(ABC) transporter
SM12261_RS06560	COG0300	oxidoreductase activity
SM12261_RS06570	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SM12261_RS06575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SM12261_RS06595	COG1940	carbohydrate kinase activity
SM12261_RS06610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SM12261_RS06620	COG3064	Membrane
SM12261_RS06630	COG2972	Histidine kinase
SM12261_RS06635	COG4753	response regulator
SM12261_RS06635	COG2207	Transcriptional regulator
SM12261_RS06640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SM12261_RS06640	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SM12261_RS06645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SM12261_RS06650	COG0785	Cytochrome C biogenesis protein
SM12261_RS06655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SM12261_RS06665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SM12261_RS06690	COG1113	amino acid transport
SM12261_RS06700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SM12261_RS06725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SM12261_RS06730	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SM12261_RS06735	COG0626	cystathionine gamma-synthase activity
SM12261_RS06745	COG4166	transmembrane transport
SM12261_RS06755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SM12261_RS06790	COG2827	Endonuclease containing a URI domain
SM12261_RS06795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SM12261_RS06800	COG1098	S1 RNA binding domain
SM12261_RS06815	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SM12261_RS06820	COG0629	single-stranded DNA binding
SM12261_RS06840	COG0017	Asparaginyl-tRNA synthetase
SM12261_RS06845	COG0436	Aminotransferase
SM12261_RS06915	COG3711	transcriptional antiterminator
SM12261_RS06935	COG0242	peptide deformylase activity
SM12261_RS06950	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SM12261_RS06955	COG0488	(ABC) transporter
SM12261_RS06960	COG0617	tRNA 3'-terminal CCA addition
SM12261_RS06970	COG1307	EDD domain protein, DegV family
SM12261_RS06990	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SM12261_RS06995	COG0492	ferredoxin-NADP+ reductase activity
SM12261_RS07005	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SM12261_RS07015	COG0251	oxidation-reduction process
SM12261_RS07035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SM12261_RS07045	COG4193	domain, Protein
SM12261_RS07045	COG5263	repeat protein
SM12261_RS07055	COG3935	DnaD domain protein
SM12261_RS07100	COG1363	Peptidase, m42
SM12261_RS07105	COG1114	Component of the transport system for branched-chain amino acids
SM12261_RS07120	COG1573	uracil-dna glycosylase
SM12261_RS07180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SM12261_RS07185	COG0765	amino acid transport
SM12261_RS07190	COG0765	amino acid transport
SM12261_RS07195	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SM12261_RS07200	COG3842	ATPase activity
SM12261_RS07210	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SM12261_RS07215	COG0215	cysteine-tRNA ligase activity
SM12261_RS07225	COG0456	acetyltransferase
SM12261_RS07230	COG1045	serine acetyltransferase
SM12261_RS07235	COG1185	polyribonucleotide nucleotidyltransferase activity
SM12261_RS07250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SM12261_RS07255	COG3620	sequence-specific DNA binding
SM12261_RS07260	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
SM12261_RS07290	COG0732	type I restriction modification DNA specificity domain
SM12261_RS07290	COG0732	type I restriction modification DNA specificity domain
SM12261_RS07300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SM12261_RS07310	COG1940	carbohydrate kinase activity
SM12261_RS07320	COG2190	(PTS) system
SM12261_RS07320	COG1263	PTS System
SM12261_RS07320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SM12261_RS07335	COG1621	beta-fructofuranosidase activity
SM12261_RS07340	COG1609	Transcriptional regulator
SM12261_RS07355	COG3425	synthase
SM12261_RS07370	COG0515	serine threonine protein kinase
SM12261_RS07370	COG2815	serine threonine protein kinase
SM12261_RS07375	COG0631	protein serine/threonine phosphatase activity
SM12261_RS07380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SM12261_RS07380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SM12261_RS07390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SM12261_RS07400	COG0194	GDP metabolic process
SM12261_RS07420	COG0799	negative regulation of ribosome biogenesis
SM12261_RS07425	COG1713	HD superfamily hydrolase involved in NAD metabolism
SM12261_RS07430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SM12261_RS07435	COG1534	Rna-binding protein
SM12261_RS07440	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SM12261_RS07460	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
SM12261_RS07470	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SM12261_RS07490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SM12261_RS07495	COG1063	alcohol dehydrogenase
SM12261_RS07525	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SM12261_RS07530	COG0439	Biotin carboxylase
SM12261_RS07545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SM12261_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
SM12261_RS07555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SM12261_RS07565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SM12261_RS07580	COG1024	Enoyl-CoA hydratase
SM12261_RS07585	COG0527	aspartate kinase activity
SM12261_RS07610	COG1115	amino acid carrier protein
SM12261_RS07635	COG0681	Belongs to the peptidase S26 family
SM12261_RS07645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SM12261_RS07660	COG2197	response regulator
SM12261_RS07665	COG4585	Histidine kinase
SM12261_RS07705	COG0745	RESPONSE REGULATOR receiver
SM12261_RS07710	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SM12261_RS07720	COG0116	Belongs to the methyltransferase superfamily
SM12261_RS07750	COG4166	transmembrane transport
SM12261_RS07755	COG1091	dTDP-4-dehydrorhamnose reductase activity
SM12261_RS07760	COG1088	dTDP-glucose 4,6-dehydratase activity
SM12261_RS07770	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SM12261_RS07775	COG0438	transferase activity, transferring glycosyl groups
SM12261_RS07785	COG0562	UDP-galactopyranose mutase
SM12261_RS07800	COG1216	Glycosyl transferase, family 2
SM12261_RS07805	COG1442	glycosyl transferase family 8
SM12261_RS07805	COG1216	Glycosyl transferase, family 2
SM12261_RS07815	COG0297	glycogen (starch) synthase activity
SM12261_RS07825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SM12261_RS07830	COG0489	protein tyrosine kinase activity
SM12261_RS07835	COG3944	biosynthesis protein
SM12261_RS07850	COG4166	transmembrane transport
SM12261_RS07855	COG0366	Alpha amylase catalytic
SM12261_RS07880	COG0768	penicillin binding
SM12261_RS07885	COG4839	cell division protein FtsL
SM12261_RS07915	COG0386	Belongs to the glutathione peroxidase family
SM12261_RS07925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SM12261_RS07930	COG3620	sequence-specific DNA binding
SM12261_RS07950	COG1653	transport
SM12261_RS07955	COG0395	ABC-type sugar transport system, permease component
SM12261_RS07960	COG4209	transmembrane transport
SM12261_RS07970	COG2169	Transcriptional regulator
SM12261_RS07975	COG1373	ATPase (AAA superfamily
SM12261_RS08000	COG2826	transposase and inactivated derivatives, IS30 family
SM12261_RS08100	COG1396	sequence-specific DNA binding
SM12261_RS08105	COG0582	viral genome integration into host DNA
SM12261_RS08110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SM12261_RS08115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SM12261_RS08120	COG1668	transmembrane transport
SM12261_RS08125	COG4152	abc transporter atp-binding protein
SM12261_RS08130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SM12261_RS08130	COG0072	phenylalanine-tRNA ligase activity
SM12261_RS08135	COG0456	acetyltransferase
SM12261_RS08150	COG0671	phosphoesterase, PA-phosphatase related
SM12261_RS08155	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SM12261_RS08170	COG1122	ATPase activity
SM12261_RS08185	COG0569	domain protein
SM12261_RS08190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SM12261_RS08195	COG1882	Formate acetyltransferase
SM12261_RS08200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SM12261_RS08220	COG0765	amino acid transport
SM12261_RS08235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SM12261_RS08245	COG0440	acetolactate synthase activity
SM12261_RS08250	COG0028	Belongs to the TPP enzyme family
SM12261_RS08255	COG1461	Dihydroxyacetone kinase
SM12261_RS08265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SM12261_RS08285	COG1132	(ABC) transporter
SM12261_RS08325	COG1316	TRANSCRIPTIONal
SM12261_RS08335	COG0802	atpase or kinase
SM12261_RS08360	COG1523	belongs to the glycosyl hydrolase 13 family
SM12261_RS08370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SM12261_RS08375	COG2723	6-phospho-beta-galactosidase activity
SM12261_RS08385	COG0750	zinc metalloprotease
SM12261_RS08390	COG4589	Belongs to the CDS family
SM12261_RS08395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SM12261_RS08435	COG2972	Histidine kinase
SM12261_RS08440	COG4753	response regulator
SM12261_RS08440	COG2207	Transcriptional regulator
SM12261_RS08445	COG1840	ABC-type Fe3 transport system, periplasmic component
SM12261_RS08450	COG1840	ABC-type Fe3 transport system, periplasmic component
SM12261_RS08455	COG3842	ATPase activity
SM12261_RS08460	COG1178	ABC-type Fe3 transport system permease component
SM12261_RS08470	COG2848	UPF0210 protein
SM12261_RS08475	COG3830	Belongs to the UPF0237 family
SM12261_RS08485	COG0202	RNA polymerase activity
SM12261_RS08490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SM12261_RS08500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SM12261_RS08505	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SM12261_RS08515	COG0201	protein transport
SM12261_RS08530	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SM12261_RS08550	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SM12261_RS08570	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SM12261_RS08595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SM12261_RS08625	COG0602	queuosine metabolic process
SM12261_RS08655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SM12261_RS08665	COG0285	dihydrofolate synthase activity
SM12261_RS08690	COG1393	Belongs to the ArsC family
SM12261_RS08700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SM12261_RS08705	COG0006	proline dipeptidase activity
SM12261_RS08710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SM12261_RS08735	COG2818	Glycosylase
SM12261_RS08765	COG1780	Probably involved in ribonucleotide reductase function
SM12261_RS08775	COG2207	Transcriptional regulator
SM12261_RS08775	COG4753	response regulator
SM12261_RS08780	COG2972	Histidine kinase
SM12261_RS08800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SM12261_RS08805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SM12261_RS08810	COG1464	Belongs to the NlpA lipoprotein family
SM12261_RS08815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SM12261_RS08830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SM12261_RS08840	COG1214	PFAM Peptidase M22, glycoprotease
SM12261_RS08860	COG0445	tRNA wobble uridine modification
SM12261_RS08865	COG0494	nUDIX hydrolase
SM12261_RS08870	COG0494	nUDIX hydrolase
SM12261_RS08895	COG1705	Flagellar rod assembly protein muramidase FlgJ
SM12261_RS08895	COG1388	LysM domain
SM12261_RS08900	COG1760	l-serine dehydratase
SM12261_RS08905	COG1760	l-serine dehydratase
SM12261_RS08925	COG1216	Glycosyl transferase, family 2
SM12261_RS08935	COG1695	Transcriptional regulator
SM12261_RS08975	COG1653	transport
SM12261_RS08980	COG0395	ABC-type sugar transport system, permease component
SM12261_RS08985	COG4209	transmembrane transport
SM12261_RS09000	COG0383	alpha-mannosidase activity
SM12261_RS09010	COG3537	Alpha-1,2-mannosidase
SM12261_RS09020	COG3250	beta-galactosidase activity
SM12261_RS09030	COG0803	Belongs to the bacterial solute-binding protein 9 family
SM12261_RS09030	COG3443	Belongs to the bacterial solute-binding protein 9 family
SM12261_RS09035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SM12261_RS09040	COG1121	(ABC) transporter
SM12261_RS09045	COG1846	Transcriptional regulator
SM12261_RS09065	COG1216	Glycosyl transferase, family 2
SM12261_RS09065	COG0463	Glycosyl transferase, family 2
SM12261_RS09070	COG1088	dTDP-glucose 4,6-dehydratase activity
SM12261_RS09085	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SM12261_RS09095	COG1696	Membrane protein involved in D-alanine export
SM12261_RS09110	COG2211	Major facilitator Superfamily
SM12261_RS09115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SM12261_RS09120	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SM12261_RS09140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SM12261_RS09165	COG3201	nicotinamide mononucleotide transporter
SM12261_RS09170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SM12261_RS09175	COG0542	response to heat
SM12261_RS09180	COG4463	regulation of RNA biosynthetic process
SM12261_RS09185	COG1116	anion transmembrane transporter activity
SM12261_RS09190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SM12261_RS09195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SM12261_RS09215	COG0305	Participates in initiation and elongation during chromosome replication
SM12261_RS09235	COG1040	competence protein
SM12261_RS09240	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SM12261_RS09245	COG1739	Uncharacterized protein family UPF0029
SM12261_RS09270	COG3942	CHAP domain
SM12261_RS09280	COG1792	Involved in formation and maintenance of cell shape
SM12261_RS09285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SM12261_RS09290	COG1122	ATPase activity
SM12261_RS09295	COG1122	ATPase activity
SM12261_RS09300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SM12261_RS09310	COG0612	Peptidase, M16
SM12261_RS09315	COG0612	Peptidase, M16
SM12261_RS09320	COG2501	S4 domain
SM12261_RS09330	COG0516	GMP reductase activity
SM12261_RS09330	COG0517	IMP dehydrogenase activity
SM12261_RS09335	COG0180	Tryptophanyl-tRNA synthetase
SM12261_RS09340	COG0488	(ABC) transporter
SM12261_RS09350	COG1511	domain protein
SM12261_RS09350	COG1511	domain protein
SM12261_RS09395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SM12261_RS09400	COG1475	DNA binding