locus-tag class description M594_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) M594_RS00020 ENOG4105C3G gtp-binding protein M594_RS00030 ENOG4108JA2 transcriptioN-repair coupling factor M594_RS00035 ENOG41082I2 s4 domain protein M594_RS00055 ENOG4108UGV hypoxanthine phosphoribosyltransferase M594_RS00060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) M594_RS00120 ENOG4107Z0P This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) M594_RS00130 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) M594_RS00145 ENOG4105C5T Phosphoribosyl pyrophosphate synthase M594_RS00150 ENOG4105K4P CoA-binding domain protein M594_RS00155 ENOG4105HMI Membrane M594_RS00160 ENOG4105CHM Aminotransferase M594_RS00175 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) M594_RS00195 ENOG4108JJA ABC, transporter M594_RS00200 ENOG4107VK6 Transport protein ComB M594_RS00210 ENOG4107QIK phosphoribosylformylglycinamidine synthase M594_RS00215 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase M594_RS00220 ENOG4105CXB phosphoribosylaminoimidazole synthetase M594_RS00225 ENOG4108V3E phosphoribosylglycinamide formyltransferase M594_RS00235 ENOG4105DC1 bifunctional purine biosynthesis protein purh M594_RS00240 ENOG4105C12 Phosphoribosylglycinamide synthetase M594_RS00245 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) M594_RS00250 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit M594_RS00275 ENOG4105C83 adenylosuccinate lyase M594_RS00280 ENOG41069UX Beta-N-acetyl-hexosaminidase M594_RS00285 ENOG4105FDP GntR family transcriptional regulator M594_RS00295 ENOG4108IQ3 PTS system M594_RS00300 ENOG4105ETZ PTS System M594_RS00305 ENOG4105F3R pts system mannose fructose sorbose family iid M594_RS00315 ENOG4105E70 isomerase M594_RS00320 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) M594_RS00330 ENOG4105VPX protein, conserved in bacteria M594_RS00340 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase M594_RS00345 ENOG4105VFE sira family M594_RS00350 ENOG4108UW5 maltose o-acetyltransferase M594_RS00390 ENOG4105CZN Potassium uptake protein M594_RS00395 ENOG4105C5I Dehydrogenase M594_RS00410 ENOG4108YBA Histidine kinase M594_RS00475 ENOG4105DZR Type I site-specific deoxyribonuclease M594_RS00515 ENOG4105VG1 fes assembly suf system protein M594_RS00530 ENOG4105CUT histidyl-tRNA synthetase M594_RS00540 ENOG4105VZ8 Transcriptional regulator M594_RS00590 ENOG4105FKQ transcriptional regulator M594_RS00595 ENOG4108VP7 maltodextrose utilization protein MalA M594_RS00600 ENOG4105EG2 ABC transporter, permease M594_RS00605 ENOG4105D56 permease protein M594_RS00610 ENOG4107FKK extracellular solute-binding protein family 1 M594_RS00615 ENOG4107SBB 4-alpha-glucanotransferase (EC 2.4.1.25) M594_RS00620 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) M594_RS00645 ENOG4105DHI Methyltransferase M594_RS00665 ENOG4105BZ4 penicillin-binding protein M594_RS00670 ENOG4108UZ3 Transporter M594_RS00685 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase M594_RS00700 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase M594_RS00710 ENOG4105BZ1 (ABC) transporter M594_RS00715 ENOG4105BZ1 (ABC) transporter M594_RS00725 ENOG4107QYV phosphohexose isomerase M594_RS00830 ENOG4105D98 threonine synthase M594_RS00835 ENOG4105UQX Mate efflux family protein M594_RS00855 ENOG4105KA3 membrAne M594_RS00860 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) M594_RS00880 ENOG4105CE4 GlcNAc 6-P deacetylase M594_RS00925 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) M594_RS00945 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins M594_RS00960 ENOG4105CV1 Transketolase (EC 2.2.1.1) M594_RS00970 ENOG4105KJF protein tyrosine phosphatase M594_RS00980 ENOG4105C0A alcohol dehydrogenase M594_RS00990 ENOG4105C19 ABC transporter M594_RS00995 ENOG4107RBB ABC transporter, permease M594_RS01000 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase M594_RS01010 ENOG4105BZ4 penicillin-binding protein M594_RS01115 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) M594_RS01140 ENOG4105C88 aminopeptidase M594_RS01145 ENOG4107BMA Transglycosylase associated protein M594_RS01155 ENOG4105CTZ aminopeptidase c M594_RS01160 ENOG4105F3R pts system mannose fructose sorbose family iid M594_RS01165 ENOG4105ETZ PTS System M594_RS01180 ENOG4105DQF Hydrolase M594_RS01185 ENOG4105C7N Xanthine uracil vitamin C permease M594_RS01195 ENOG4105EEI dihydropteroate synthase M594_RS01200 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase M594_RS01210 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase M594_RS01220 ENOG4105ETE Transcriptional regulator (LacI family M594_RS01225 ENOG4107RB3 L-asparaginase M594_RS01230 ENOG4108X4Q Hydrolase M594_RS01235 ENOG4107YZX Universal stress protein M594_RS01245 ENOG4105CHM Aminotransferase M594_RS01255 ENOG4105DIB Oligopeptide-binding protein M594_RS01260 ENOG4105C0X amino acid M594_RS01265 ENOG4105F8V Hydrolase, tatD family M594_RS01280 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) M594_RS01285 ENOG4105DJV ribulose-phosphate 3-epimerase M594_RS01290 ENOG4105FJ0 thiamine M594_RS01300 ENOG4105EQI Metal Dependent Phosphohydrolase M594_RS01305 ENOG4105DFT pur operon repressor M594_RS01315 ENOG4105F1A Pyruvate formate-lyase M594_RS01355 ENOG4108RWN rrna methyltransferase M594_RS01360 ENOG4105HFZ Membrane M594_RS01370 ENOG4106H78 methyltransferase M594_RS01380 ENOG41063PX domain protein M594_RS01390 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) M594_RS01400 ENOG4105ZT7 DNA-entry nuclease M594_RS01415 ENOG4105DIB Oligopeptide-binding protein M594_RS01420 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component M594_RS01425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component M594_RS01430 ENOG4105C3U ABC transporter M594_RS01435 ENOG4108JQ7 (ABC) transporter M594_RS01440 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) M594_RS01445 ENOG4105C1A potassium transporter peripheral membrane M594_RS01460 ENOG4108JJB ABC transporter M594_RS01475 ENOG4108SAX Membrane M594_RS01480 ENOG410841Q phosphoesterase PA-phosphatase related protein M594_RS01490 ENOG4108Z7F N-acetyltransferase M594_RS01500 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) M594_RS01505 ENOG4108IUX (ABC) transporter M594_RS01510 ENOG4105RHA ABC transporter, permease M594_RS01515 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) M594_RS01530 ENOG4108IMY Transcriptional regulator M594_RS01565 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) M594_RS01575 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) M594_RS01585 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) M594_RS01625 ENOG4108IUW ABC transporter M594_RS01655 ENOG4108JJB ABC transporter M594_RS01685 ENOG41067QW Transcriptional regulator M594_RS01690 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) M594_RS01710 ENOG4105ESP cell wall surface anchor family protein M594_RS01715 ENOG4108V06 Glutathione peroxidase M594_RS01745 ENOG41068DC Essential cell division protein (By similarity) M594_RS01750 ENOG4105CJN penicillin-binding protein M594_RS01780 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) M594_RS01800 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) M594_RS01810 ENOG4105FE9 pseudouridine synthase M594_RS01830 ENOG4105CM4 permease protein M594_RS01835 ENOG4105DHS permease protein M594_RS01840 ENOG4105CN9 Peptidase m42 family protein M594_RS01870 ENOG4105KV4 Transcriptional regulator M594_RS01875 ENOG4105C5F glutamine synthetase M594_RS01905 ENOG4107QTH restriction modification system DNA specificity domain M594_RS01915 ENOG4108F3G Type I restriction-modification system, R subunit M594_RS01950 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) M594_RS01960 ENOG4105K59 histidine triad (HIT) protein M594_RS02005 ENOG4108IW0 caax amino terminal protease family protein M594_RS02025 ENOG4105CHV Transcription elongation factor NusA M594_RS02030 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination M594_RS02080 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) M594_RS02090 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) M594_RS02110 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) M594_RS02130 ENOG4108VDD TRNA binding domain protein M594_RS02135 ENOG4105EMU Dehydrogenase M594_RS02160 ENOG4105WPN DNA integration recombination invertion protein M594_RS02175 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) M594_RS02290 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase M594_RS02310 ENOG4108IJ8 ABC transporter M594_RS02315 ENOG4105E90 ABC transporter M594_RS02325 ENOG4105PGM cation diffusion facilitator family transporter M594_RS02330 ENOG4105CQ4 Transcriptional regulator M594_RS02335 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) M594_RS02340 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 M594_RS02355 ENOG4105C2W permease M594_RS02370 ENOG4105CGK Exodeoxyribonuclease III M594_RS02380 ENOG41082BM Transcriptional regulator, arsr family M594_RS02400 ENOG4105BZ1 (ABC) transporter M594_RS02405 ENOG4105BZ1 (ABC) transporter M594_RS02410 ENOG4105D3Q Sugar transferase M594_RS02415 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase M594_RS02420 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) M594_RS02425 ENOG4105CRQ synthase (Component I) M594_RS02430 ENOG4105DDQ anthranilate synthase M594_RS02445 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase M594_RS02460 ENOG4106A3R peptidase M594_RS02500 ENOG4105D1H recombination factor protein RarA M594_RS02515 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) M594_RS02525 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) M594_RS02530 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) M594_RS02535 ENOG4105DPN Oligoendopeptidase f M594_RS02550 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) M594_RS02560 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) M594_RS02565 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase M594_RS02575 ENOG4105K63 Thioredoxin M594_RS02590 ENOG4105VAW lrga family M594_RS02595 ENOG41067MG lrgb family M594_RS02625 ENOG4105CZV ABC transporter M594_RS02630 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family M594_RS02650 ENOG4108DBC nitroreductase M594_RS02675 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) M594_RS02680 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) M594_RS02695 ENOG4105CB5 ATP-dependent DNA helicase recG M594_RS02700 ENOG4105I82 acetyl xylan esterase M594_RS02705 ENOG4108478 ec 3.2.1.18 M594_RS02720 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component M594_RS02725 ENOG4105DRS transport system, permease M594_RS02730 ENOG4108R66 Conserved Protein M594_RS02755 ENOG4107RF6 penicillin-binding protein M594_RS02770 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) M594_RS02795 ENOG4105DFA alanine racemase domain protein M594_RS02815 ENOG4105MMF Cell division protein DIVIVA M594_RS02830 ENOG4105MYU Immunoglobulin A1 protease M594_RS02840 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) M594_RS02860 ENOG4105EHG Permease protein M594_RS02880 ENOG4105F6E Acyl-transferase M594_RS02885 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic M594_RS02895 ENOG4105EGD dinuclear metal center protein, YbgI family M594_RS02900 ENOG4107VFR oxidoreductase M594_RS02905 ENOG4105CMR udp-glucose 4-epimerase M594_RS02910 ENOG4105CKK Glycosyl transferase, family 2 M594_RS02930 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) M594_RS02950 ENOG4105KME endoribonuclease L-psp M594_RS02960 ENOG4105CHW UPF0052 protein M594_RS02970 ENOG4105CAY ferredoxin--nadp reductase M594_RS02975 ENOG4105C8B TIGR00159 family M594_RS02995 ENOG4105EPR degv family M594_RS03005 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate M594_RS03010 ENOG4105C5H ABC transporter M594_RS03025 ENOG4107YDN peptide deformylase M594_RS03065 ENOG4105CHM Aminotransferase M594_RS03070 ENOG4105C5S asparaginyl-tRNA synthetase M594_RS03085 ENOG4108UUM single-stranded DNA-binding protein M594_RS03090 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) M594_RS03105 ENOG41060GV RNA binding s1 domain protein M594_RS03110 ENOG41060K3 Methyltransferase M594_RS03115 ENOG4105VC4 domain protein M594_RS03140 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) M594_RS03150 ENOG4105DIB Oligopeptide-binding protein M594_RS03160 ENOG4105C28 cystathionine M594_RS03165 ENOG4105C87 Aminotransferase class I and II M594_RS03170 ENOG4105C0D helicase M594_RS03205 ENOG4105C85 amino acid M594_RS03215 ENOG4105CJ1 ABC, transporter M594_RS03225 ENOG41067QW Transcriptional regulator M594_RS03235 ENOG4105DAP Nicotinate phosphoribosyltransferase M594_RS03245 ENOG4105D9U N-acetyltransferase M594_RS03250 ENOG4107QIV Cytochrome c biogenesis protein M594_RS03255 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M594_RS03260 ENOG4105E0X reductase M594_RS03265 ENOG4105EQD regulatoR M594_RS03270 ENOG4105C2F Histidine kinase M594_RS03305 ENOG4105DKQ ROK family M594_RS03325 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) M594_RS03330 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase M594_RS03340 ENOG4108IXY short-chain dehydrogenase reductase M594_RS03355 ENOG4105N5T Radical SAM Protein M594_RS03370 ENOG4107SUZ Sodium/hydrogen exchanger family M594_RS03390 ENOG4105VCC 30S ribosomal protein S21 M594_RS03415 ENOG4105CSA Coproporphyrinogen iii oxidase M594_RS03425 ENOG4105D4U had-superfamily hydrolase, subfamily iia M594_RS03435 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) M594_RS03445 ENOG4105ECY inositol monophosphatase M594_RS03450 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B M594_RS03455 ENOG4105CVA phosphate M594_RS03460 ENOG4105C8U phosphate abc transporter M594_RS03465 ENOG4105E2Z phosphate ABC transporter (Permease M594_RS03470 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) M594_RS03475 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) M594_RS03480 ENOG4108UTW Plays a role in the regulation of phosphate uptake M594_RS03485 ENOG4106PMH Extracellular solute-binding protein family 3 M594_RS03495 ENOG4107FQX Alpha-acetolactate decarboxylase M594_RS03510 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) M594_RS03525 ENOG4108HM4 ABC transporter M594_RS03530 ENOG4105D85 methylase M594_RS03535 ENOG4105F6A helicase M594_RS03540 ENOG4105ECI YeeC-like protein M594_RS03565 ENOG4108IUW ABC transporter M594_RS03575 ENOG4105DR4 Methyltransferase M594_RS03600 ENOG4105EVN Prephenate dehydrogenase M594_RS03615 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) M594_RS03620 ENOG4105CQC Prephenate dehydratase M594_RS03625 ENOG4108RCF TRANSCRIPTIONal M594_RS03630 ENOG4105KPE licD family M594_RS03640 ENOG4105KPE licD family M594_RS03645 ENOG4105KPE licD family M594_RS03665 ENOG4105D6E homoserine dehydrogenase M594_RS03675 ENOG4105E0X reductase M594_RS03680 ENOG4105BZ1 (ABC) transporter M594_RS03690 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) M594_RS03695 ENOG4108VZM 50s ribosomal protein L10 M594_RS03725 ENOG4105DA5 (ABC) transporter M594_RS03745 ENOG4107R37 Glutamate dehydrogenase M594_RS03750 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) M594_RS03760 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) M594_RS03765 ENOG4105MMD transcriptional regulator M594_RS03770 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs M594_RS03780 ENOG4105C5H ABC transporter M594_RS03810 ENOG4105VB6 UPF0109 protein M594_RS03835 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase M594_RS03845 ENOG4105VEM Conserved domain protein M594_RS03850 ENOG4105VKD bioY protein M594_RS03855 ENOG4105DC8 reductase M594_RS03860 ENOG4107X8C Efflux transporter RND family MFP subunit M594_RS03865 ENOG4105C19 ABC transporter M594_RS03870 ENOG4107RBB ABC transporter, permease M594_RS03875 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) M594_RS03900 ENOG4107Y49 methyltransferase M594_RS03905 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) M594_RS03915 ENOG4105KG3 cytidine deaminase M594_RS03920 ENOG4105DIH basic membrane M594_RS03925 ENOG4108JQ9 ABC transporter M594_RS03930 ENOG4105UIB (ABC) transporter M594_RS03950 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M594_RS03965 ENOG41075D4 Aminoglycoside 6-adenylyltransferase M594_RS03975 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M594_RS03980 ENOG4105CM2 brancheD-chain amino acid aminotransferase M594_RS04000 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) M594_RS04005 ENOG4108ZGC gaf domain protein M594_RS04010 ENOG4105C6E dna polymerase iii M594_RS04025 ENOG4105JRK feS assembly protein SufD M594_RS04030 ENOG4105C9B Cysteine desulfurase M594_RS04035 ENOG4108UNV SUF system FeS assembly protein, NifU family M594_RS04040 ENOG4105DIW FeS assembly protein SUFB M594_RS04045 ENOG4105CUB amino acid M594_RS04050 ENOG4108JYZ YitT family M594_RS04055 ENOG4108RCR degv family M594_RS04060 ENOG4105K70 DNA-binding protein M594_RS04065 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) M594_RS04070 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M594_RS04075 ENOG4108Z6X (sortase) family M594_RS04110 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) M594_RS04135 ENOG4105DX0 Hemolysin A M594_RS04140 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) M594_RS04145 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) M594_RS04150 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) M594_RS04160 ENOG4105C79 DNA protecting protein DprA M594_RS04165 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) M594_RS04170 ENOG4105WD1 Membrane M594_RS04175 ENOG4106N3A copper homeostasis protein cutc M594_RS04190 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) M594_RS04215 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 M594_RS04240 ENOG4105CFP Peptidase U32 M594_RS04250 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) M594_RS04285 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) M594_RS04305 ENOG4105CDA abc transporter atp-binding protein M594_RS04325 ENOG4108Z66 YbaK ebsC protein M594_RS04340 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) M594_RS04345 ENOG4108YZ4 nudix hydrolase M594_RS04355 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) M594_RS04365 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) M594_RS04370 ENOG4108QXE glycerophosphoryl diester phosphodiesterase M594_RS04435 ENOG4105EJJ Dehydrogenase M594_RS04440 ENOG4108KN0 Choline kinase M594_RS04465 ENOG4105DT3 PTS system, galactitol-specific IIc component M594_RS04490 ENOG4105D2M Aldolase M594_RS04500 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M594_RS04505 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) M594_RS04510 ENOG4105WAZ (Glutaredoxin-like protein) NrdH M594_RS04515 ENOG4105KRI phosphocarrier protein (HPr M594_RS04520 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) M594_RS04525 ENOG4105DSE periplasmic solute binding protein M594_RS04540 ENOG4105DSE periplasmic solute binding protein M594_RS04550 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) M594_RS04555 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) M594_RS04560 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) M594_RS04570 ENOG410807C QueT transporter M594_RS04580 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) M594_RS04590 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) M594_RS04595 ENOG41069HH 4-oxalocrotonate tautomerase M594_RS04600 ENOG4107104 thymidine kinase M594_RS04610 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) M594_RS04635 ENOG41065S2 pneumococcal vaccine antigen M594_RS04645 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) M594_RS04660 ENOG4105DVF Cytosine-specific methyltransferase M594_RS04685 ENOG4105QEK Transcriptional regulator M594_RS04690 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) M594_RS04700 ENOG4107RJ1 sodium solute M594_RS04715 ENOG4105CK5 oxidoreductase M594_RS04830 ENOG4105KIS phospholipid-binding protein M594_RS04835 ENOG4105C5Q Transcriptional regulator M594_RS04960 ENOG4108WZA zeta toxin M594_RS05025 ENOG4108IG5 Transcriptional regulator M594_RS05070 ENOG4106ZEE Diacylglycerol kinase M594_RS05075 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase M594_RS05080 ENOG4108IUK alpha amylase, catalytic M594_RS05105 ENOG4105CXN decarboxylase M594_RS05110 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) M594_RS05135 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M594_RS05155 ENOG410667J hydrolase M594_RS05185 ENOG4107YJ4 chain length determinant protein M594_RS05200 ENOG4107YSK Glycerol-3-phosphate cytidylyltransferase M594_RS05205 ENOG4108KMV Glycosyl transferase (Group 1 M594_RS05215 ENOG4107QRS glycosyltransferase group 2 family protein M594_RS05225 ENOG4107QRS glycosyltransferase group 2 family protein M594_RS05250 ENOG4108KMV Glycosyl transferase (Group 1 M594_RS05265 ENOG4105DVF Cytosine-specific methyltransferase M594_RS05295 ENOG4108RDQ ABC transporter M594_RS05335 ENOG4105EKQ RNA-directed DNA polymerase M594_RS05385 ENOG4105KIS phospholipid-binding protein M594_RS05400 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) M594_RS05405 ENOG4105C5Q Transcriptional regulator M594_RS05480 ENOG4108RDQ ABC transporter M594_RS05500 ENOG4108WZA zeta toxin M594_RS05515 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) M594_RS05545 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) M594_RS05570 ENOG4105MU5 relaxase mobilization nuclease domain protein M594_RS05580 ENOG4105WT3 Transcriptional regulator M594_RS05590 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E M594_RS05610 ENOG4105DVE abc transporter atp-binding protein M594_RS05615 ENOG4108IMY Transcriptional regulator M594_RS05630 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) M594_RS05640 ENOG4105CMQ Chloride channel M594_RS05660 ENOG4105DF9 Lipoate-protein, ligase M594_RS05670 ENOG4105C7S Dehydrogenase M594_RS05675 ENOG4105CPP Dehydrogenase, E1 component M594_RS05680 ENOG4107RUY (E1 component), alpha subunit M594_RS05685 ENOG4107QMU Mate efflux family protein M594_RS05690 ENOG4105CD3 dihydroorotase M594_RS05695 ENOG4108Z4K mutator MutT protein M594_RS05710 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) M594_RS05755 ENOG4105BZW Glycerate kinase M594_RS05760 ENOG4105EAC phosphoserine phosphatase M594_RS05780 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) M594_RS05785 ENOG4105C26 Dehydrogenase M594_RS05790 ENOG4108IUM Glycogen debranching enzyme M594_RS05810 ENOG4105C5H ABC transporter M594_RS05825 ENOG4105Q2H domain protein M594_RS05835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M594_RS05840 ENOG4105CEN a g-specific adenine glycosylase M594_RS05845 ENOG4108IJ2 phosphate acetyltransferase M594_RS05850 ENOG4105EMS pseudouridine synthase M594_RS05870 ENOG4105C5T Phosphoribosyl pyrophosphate synthase M594_RS05875 ENOG4105C3J Cysteine desulfurase M594_RS05905 ENOG4105C4R Atp-dependent dna helicase M594_RS05920 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase M594_RS05925 ENOG4105FH5 Membrane M594_RS05930 ENOG4105RNB M594_RS05935 ENOG4108Z3G 3H domain protein M594_RS05945 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator M594_RS05950 ENOG4105CNN ABC, transporter M594_RS05960 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) M594_RS05965 ENOG4108RVA ribokinase M594_RS05970 ENOG4105ETE Transcriptional regulator (LacI family M594_RS05985 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) M594_RS05995 ENOG4105E5Q amino acid AbC transporter M594_RS06000 ENOG4105CDA abc transporter atp-binding protein M594_RS06005 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase M594_RS06010 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) M594_RS06015 ENOG410667J hydrolase M594_RS06020 ENOG4108HCJ Hydrolase M594_RS06035 ENOG4105C19 ABC transporter M594_RS06070 ENOG4108PJD permease M594_RS06075 ENOG4108NNR transporter substrate-binding protein M594_RS06090 ENOG4105DTN riboflavin biosynthesis protein ribF M594_RS06095 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) M594_RS06115 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY M594_RS06130 ENOG4105C02 permease M594_RS06140 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen M594_RS06145 ENOG4107QIV Cytochrome c biogenesis protein M594_RS06150 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) M594_RS06170 ENOG4105CA9 Pyruvate kinase M594_RS06185 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) M594_RS06190 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) M594_RS06210 ENOG4105FM1 phage shock protein C M594_RS06215 ENOG4105BZF Glycosyl transferase (Group 1 M594_RS06220 ENOG4105W2C Glycosyl transferase M594_RS06225 ENOG4105VG1 fes assembly suf system protein M594_RS06230 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) M594_RS06235 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) M594_RS06240 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) M594_RS06255 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) M594_RS06260 ENOG4105CNI cell division protein FtsW M594_RS06285 ENOG41088CC tellurite resistance protein tehB M594_RS06295 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) M594_RS06305 ENOG410861F 50S ribosomal protein L33 M594_RS06310 ENOG4105C6X Major Facilitator M594_RS06315 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) M594_RS06320 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) M594_RS06330 ENOG4107YR5 Diacylglycerol kinase M594_RS06355 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) M594_RS06380 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) M594_RS06385 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) M594_RS06395 ENOG4105US7 Histidine kinase M594_RS06400 ENOG4108STX response regulator M594_RS06415 ENOG41061TZ Short-chain dehydrogenase reductase Sdr M594_RS06425 ENOG4107RGM aldo keto reductase M594_RS06445 ENOG4105IEH endo-beta-N-acetylglucosaminidase M594_RS06450 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) M594_RS06455 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) M594_RS06485 ENOG4105DA5 (ABC) transporter M594_RS06490 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 M594_RS06495 ENOG4105KQC Competence protein M594_RS06500 ENOG41068WN M594_RS06505 ENOG4105DCF alanine dehydrogenase M594_RS06510 ENOG4105C9A Phoh family M594_RS06520 ENOG4105RHY Pfam:UPF0157 M594_RS06525 ENOG4105QNR S1 RNA binding domain protein M594_RS06535 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) M594_RS06545 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) M594_RS06555 ENOG4105FA2 dna polymerase iii M594_RS06565 ENOG4105II7 pyrroline-5-carboxylate reductase M594_RS06580 ENOG4105C34 Pseudouridine synthase M594_RS06585 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) M594_RS06595 ENOG4108RS6 transposase M594_RS06625 ENOG4105FDU atp-dependent rna helicase M594_RS06635 ENOG4105DCI Phosphohydrolase M594_RS06650 ENOG4105WKZ CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) M594_RS06675 ENOG4106A8V Protein CrcB homolog M594_RS06685 ENOG4105CQC Prephenate dehydratase M594_RS06695 ENOG4105SFS phosphoesterase RecJ domain protein M594_RS06715 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain M594_RS06730 ENOG4105CSM endonuclease III M594_RS06745 ENOG4105C5H ABC transporter M594_RS06755 ENOG4108V0P LemA family M594_RS06775 ENOG4108UZ3 Transporter M594_RS06780 ENOG4107QK9 Beta-lactamase M594_RS06790 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) M594_RS06825 ENOG4105C3J Cysteine desulfurase M594_RS06835 ENOG4105CNU cell division protein FtsK M594_RS06840 ENOG4105DM4 PTS System M594_RS06845 ENOG4105DE4 1-phosphofructokinase M594_RS06850 ENOG4105E98 transcriptional regulator DeoR family M594_RS06860 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) M594_RS06875 ENOG4108HCJ Hydrolase M594_RS06890 ENOG4105C2N RNA methyltransferase TrmH family group 3 M594_RS06895 ENOG4105C3M thioredoxin reductase M594_RS06905 ENOG4105CDA abc transporter atp-binding protein M594_RS06910 ENOG4105E5Q amino acid AbC transporter M594_RS06915 ENOG41080E8 Transcriptional regulator, Spx MgsR family M594_RS06920 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) M594_RS06935 ENOG4108UT2 hemolysin iii M594_RS06965 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) M594_RS06990 ENOG4108ZJ4 polysaccharide deacetylase M594_RS07000 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) M594_RS07010 ENOG4108Z0Z intracellular protease Pfpi family M594_RS07020 ENOG4105DVT helicase M594_RS07030 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) M594_RS07035 ENOG4105CNT hydrolase family 2 M594_RS07040 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) M594_RS07045 ENOG4105CDA abc transporter atp-binding protein M594_RS07050 ENOG4105E5Q amino acid AbC transporter M594_RS07055 ENOG4107IN1 Protein of unknown function (DUF1797) M594_RS07060 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M594_RS07085 ENOG4105C1J atp-dependent rna helicase M594_RS07095 ENOG4105CI1 PTS System M594_RS07100 ENOG4105CRP Part of the ABC transporter FtsEX involved in M594_RS07105 ENOG4105CAK Cell division ATP-binding protein ftsE M594_RS07135 ENOG4108IV0 ABC, transporter M594_RS07140 ENOG4105C0Z ABC transporter M594_RS07145 ENOG4105CF8 branched-chain amino acid ABC transporter, permease M594_RS07150 ENOG4105C32 Amino acid ABC transporter (Permease) M594_RS07170 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) M594_RS07175 ENOG4108UK2 deaminase M594_RS07185 ENOG4108S8M degv family M594_RS07190 ENOG4105CBX hi0933 family M594_RS07200 ENOG4107TXC Transcriptional regulator M594_RS07205 ENOG4105C8J )-transporter M594_RS07210 ENOG4105DG6 mannose-6-phosphate isomerase M594_RS07215 ENOG4105CS2 ec 3.2.1.21 M594_RS07235 ENOG4105C7K acetolactate synthase M594_RS07240 ENOG4105C59 p-type ATPase M594_RS07250 ENOG4105NA0 Transcriptional regulator M594_RS07260 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) M594_RS07275 ENOG4105ETU transcriptional activator (TenA M594_RS07285 ENOG4108JJB ABC transporter M594_RS07295 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) M594_RS07325 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) M594_RS07340 ENOG4105C19 ABC transporter M594_RS07355 ENOG4105CI3 gtp-binding protein typa M594_RS07370 ENOG4105WZW rhodanese family M594_RS07380 ENOG4105WH1 Two component transcriptional regulator luxr family M594_RS07395 ENOG4105C19 ABC transporter M594_RS07415 ENOG4107RSM transcriptional regulator M594_RS07420 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase M594_RS07435 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin M594_RS07450 ENOG4108IUW ABC transporter M594_RS07485 ENOG4105D2N Aldolase M594_RS07490 ENOG4105BZU Histidine kinase M594_RS07495 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M594_RS07500 ENOG4107WD8 ABC transporter, permease M594_RS07510 ENOG4107WD8 ABC transporter, permease M594_RS07525 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) M594_RS07530 ENOG4105C1J atp-dependent rna helicase M594_RS07535 ENOG4107QN2 dihydrolipoyl dehydrogenase M594_RS07540 ENOG4105DMS mur ligase M594_RS07545 ENOG4105F1K Glutamine amidotransferase M594_RS07550 ENOG4105DC7 peptidase M24 M594_RS07555 ENOG4105PUK Membrane M594_RS07560 ENOG4105DWF phosphomethylpyrimidine kinase M594_RS07580 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA M594_RS07615 ENOG4105DVA methyltransferase M594_RS07640 ENOG4105DER m42 family M594_RS07645 ENOG4105CWM branched-chain amino acid transport system II carrier protein M594_RS07650 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) M594_RS07655 ENOG4108RG0 uracil-dna glycosylase M594_RS07685 ENOG4107UWA esterase M594_RS07700 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) M594_RS07710 ENOG4107RP9 extracellular solute-binding protein, family 3 M594_RS07715 ENOG4105EAD ABC transporter M594_RS07720 ENOG4105DRP amino acid AbC transporter M594_RS07725 ENOG4105E3J oxidoreductase M594_RS07730 ENOG4108Z40 Transcriptional regulator M594_RS07750 ENOG4107PBV potassium channel M594_RS07770 ENOG4107T0D ABC, transporter M594_RS07775 ENOG4105EWM Histidine kinase M594_RS07780 ENOG4105CJZ response regulator M594_RS07805 ENOG4105C9K Endothelin-converting enzyme 1 M594_RS07810 ENOG4105DIK (ABC) transporter M594_RS07815 ENOG4105CC5 ABC transporter M594_RS07825 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) M594_RS07860 ENOG4108IJ9 (ABC) transporter M594_RS07870 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) M594_RS07875 ENOG4105C8N cysteinyl-tRNA synthetase M594_RS07890 ENOG4105D7W serine acetyltransferase M594_RS07900 ENOG4105SYT Methylenetetrahydrofolate reductase M594_RS07905 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) M594_RS07950 ENOG41082EK Restriction modification system DNA (Specificity M594_RS07975 ENOG4105EVU fructokinase M594_RS07980 ENOG4105C5Y PTS System M594_RS07990 ENOG4105ETE Transcriptional regulator (LacI family M594_RS08000 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase M594_RS08015 ENOG4105D9P serine threonine protein kinase M594_RS08020 ENOG4108ZF3 Phosphatase M594_RS08025 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B M594_RS08035 ENOG4105C25 Primosomal protein n' M594_RS08045 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) M594_RS08065 ENOG4105DXX methyltransferase M594_RS08070 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) M594_RS08075 ENOG4108WF2 Metal Dependent Phosphohydrolase M594_RS08080 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) M594_RS08085 ENOG410812S Rna-binding protein M594_RS08090 ENOG4105CQW ribosome biogenesis GTPase YqeH M594_RS08105 ENOG4105D8X mechanosensitive ion channel M594_RS08140 ENOG4108MGR Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) M594_RS08165 ENOG4105GH9 galactofuranosyltransferase M594_RS08215 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) M594_RS08230 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) M594_RS08265 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) M594_RS08270 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase M594_RS08290 ENOG4105CHR reductase M594_RS08295 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase M594_RS08300 ENOG4105EA8 2-Nitropropane dioxygenase M594_RS08320 ENOG4105CGU Enoyl-CoA hydratase M594_RS08325 ENOG4105CFH Aspartokinase M594_RS08350 ENOG4105BZG amino acid carrier protein M594_RS08375 ENOG4105C3F Signal peptidase i M594_RS08380 ENOG4105C7H Helicase, RecD TraA family M594_RS08395 ENOG4105WH1 Two component transcriptional regulator luxr family M594_RS08400 ENOG4105ENE Histidine kinase M594_RS08440 ENOG4105CK6 Two component transcriptional regulator (Winged helix family M594_RS08445 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) M594_RS08450 ENOG41070VT M594_RS08455 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) M594_RS08490 ENOG4105ESP cell wall surface anchor family protein M594_RS08490 ENOG4105ESP cell wall surface anchor family protein M594_RS08490 ENOG4105ESP cell wall surface anchor family protein M594_RS08495 ENOG4105DIB Oligopeptide-binding protein M594_RS08500 ENOG4105GH9 galactofuranosyltransferase M594_RS08505 ENOG4105D5D udp-galactopyranose mutase M594_RS08525 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase M594_RS08530 ENOG4107TYR Glycosyl Transferase M594_RS08540 ENOG4105KPE licD family M594_RS08550 ENOG4105D75 Capsular exopolysaccharide family M594_RS08555 ENOG4105HTX biosynthesis protein M594_RS08560 ENOG4108RB3 Capsular polysaccharide biosynthesis protein M594_RS08570 ENOG4105DIB Oligopeptide-binding protein M594_RS08575 ENOG4105DIB Oligopeptide-binding protein M594_RS08580 ENOG4105CG3 alpha amylase, catalytic region M594_RS08600 ENOG4105C6N Formate acetyltransferase M594_RS08605 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) M594_RS08620 ENOG4105E5Q amino acid AbC transporter M594_RS08635 ENOG4105C7B Threonine dehydratase M594_RS08645 ENOG4108ZP8 Acetolactate synthase small subunit M594_RS08675 ENOG4105BZU Histidine kinase M594_RS08680 ENOG4105KCT ABC transporter M594_RS08685 ENOG4108M15 ABC transporter M594_RS08700 ENOG4105DP4 dak2 domain fusion protein ylov M594_RS08710 ENOG4105VB9 50S ribosomal protein l28 M594_RS08735 ENOG4105MU5 relaxase mobilization nuclease domain protein M594_RS08785 ENOG41068JE domain protein M594_RS08840 ENOG41067QW Transcriptional regulator M594_RS08875 ENOG4105BZ1 (ABC) transporter M594_RS08910 ENOG4108KGH TRANSCRIPTIONal M594_RS08915 ENOG4108MK9 spermidine N(1)-acetyltransferase M594_RS08920 ENOG4105K8N protein family UPF0079, ATPase M594_RS08945 ENOG4108IUM Glycogen debranching enzyme M594_RS08955 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) M594_RS08960 ENOG4105CS2 ec 3.2.1.21 M594_RS08970 ENOG4105DZP Membrane-associated zinc metalloprotease M594_RS08975 ENOG4105KNE Phosphatidate cytidylyltransferase M594_RS08980 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) M594_RS09045 ENOG4105DPZ Two component transcriptional regulator (Winged helix family M594_RS09090 ENOG4105CAG UPF0210 protein M594_RS09095 ENOG4105VUC UPF0237 protein M594_RS09105 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) M594_RS09110 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) M594_RS09125 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) M594_RS09135 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) M594_RS09150 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) M594_RS09170 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) M594_RS09190 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal M594_RS09215 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) M594_RS09245 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) M594_RS09260 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase M594_RS09270 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) M594_RS09280 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase M594_RS09305 ENOG410888K transcriptional regulator, Spx M594_RS09310 ENOG4105DC7 peptidase M24 M594_RS09315 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) M594_RS09340 ENOG4108R3E Dna-3-methyladenine glycosylase i M594_RS09370 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) M594_RS09385 ENOG4105MTF NrdI protein M594_RS09400 ENOG4105C2F Histidine kinase M594_RS09420 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) M594_RS09425 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) M594_RS09430 ENOG4105D01 (LipO)protein M594_RS09435 ENOG4105EAB amino acid AbC transporter M594_RS09475 ENOG4105WT3 Transcriptional regulator M594_RS09480 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) M594_RS09490 ENOG41072GX Peptidase M22 Glycoprotease M594_RS09510 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) M594_RS09515 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) M594_RS09520 ENOG4105M6F mutator MutT protein M594_RS09560 ENOG4105EJQ L-serine dehydratase M594_RS09565 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) M594_RS09575 ENOG4108RYC glycosyltransferase M594_RS09590 ENOG4105U3E Transcriptional regulator M594_RS09635 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component M594_RS09655 ENOG4105C8I hydrolase, family 38 M594_RS09665 ENOG4105CWX Alpha-1,2-mannosidase M594_RS09675 ENOG4105C0A alcohol dehydrogenase M594_RS09680 ENOG4105DSE periplasmic solute binding protein M594_RS09690 ENOG4105FDK ABC transporter M594_RS09695 ENOG41067TZ transcriptional regulator, MarR family M594_RS09705 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD M594_RS09715 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein M594_RS09730 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) M594_RS09735 ENOG4105C6V Glycerol-3-phosphate dehydrogenase M594_RS09755 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) M594_RS09780 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) M594_RS09785 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit M594_RS09805 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component M594_RS09815 ENOG4105C2M dna polymerase I M594_RS09835 ENOG4105CDU Replicative dna helicase M594_RS09855 ENOG4105MJ2 Competence protein M594_RS09865 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein M594_RS09890 ENOG41068JE domain protein M594_RS09900 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) M594_RS09905 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) M594_RS09910 ENOG4108JJB ABC transporter M594_RS09915 ENOG4108JJB ABC transporter M594_RS09920 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase M594_RS09935 ENOG4105C1V Peptidase, M16 M594_RS09940 ENOG410848D S4 domain protein YaaA M594_RS09950 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) M594_RS09955 ENOG4105C31 Tryptophanyl-tRNA synthetase M594_RS09960 ENOG4105C5H ABC transporter M594_RS09970 ENOG4105ECB domain protein M594_RS09970 ENOG4105ECB domain protein M594_RS10015 ENOG4105C0H protease M594_RS10020 ENOG4105FA0 parb-like partition protein