locus-tag	class	description
M594_RS00010	COG0592	DNA-directed DNA polymerase activity
M594_RS00020	COG0012	GTP binding
M594_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M594_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M594_RS00060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M594_RS00120	COG0756	dUTP diphosphatase activity
M594_RS00130	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M594_RS00145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M594_RS00150	COG1832	CoA-binding protein
M594_RS00155	COG2855	membrane
M594_RS00160	COG0436	Aminotransferase
M594_RS00175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M594_RS00195	COG2274	protein secretion by the type I secretion system
M594_RS00200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M594_RS00210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M594_RS00220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M594_RS00225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M594_RS00235	COG0138	bifunctional purine biosynthesis protein purh
M594_RS00240	COG0151	Belongs to the GarS family
M594_RS00245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M594_RS00275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M594_RS00280	COG3583	domain protein
M594_RS00280	COG3525	Glycosyl hydrolase, family 20, catalytic domain
M594_RS00280	COG3064	Membrane
M594_RS00295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M594_RS00300	COG3715	PTS system
M594_RS00305	COG3716	PTS system mannose fructose sorbose family IID component
M594_RS00315	COG2222	sugar isomerase
M594_RS00330	COG1937	Protein conserved in bacteria
M594_RS00340	COG0446	pyridine nucleotide-disulphide oxidoreductase
M594_RS00345	COG0425	Belongs to the sulfur carrier protein TusA family
M594_RS00345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M594_RS00350	COG0110	maltose O-acetyltransferase activity
M594_RS00370	COG0784	Response regulator, receiver
M594_RS00370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M594_RS00390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M594_RS00395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M594_RS00410	COG5002	protein histidine kinase activity
M594_RS00475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
M594_RS00500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M594_RS00515	COG2151	metal-sulfur cluster biosynthetic enzyme
M594_RS00530	COG0124	histidyl-tRNA synthetase
M594_RS00540	COG1476	TRANSCRIPTIONal
M594_RS00590	COG1609	Transcriptional regulator
M594_RS00595	COG5521	maltodextrose utilization protein MalA
M594_RS00600	COG3833	ABC-type maltose transport systems, permease component
M594_RS00605	COG1175	transmembrane transport
M594_RS00610	COG2182	Extracellular solute-binding protein
M594_RS00615	COG1640	4-alpha-glucanotransferase
M594_RS00620	COG0058	SHG alpha-glucan phosphorylase activity
M594_RS00645	COG2226	methyltransferase
M594_RS00655	COG2217	Heavy metal translocating P-type atpase
M594_RS00665	COG4499	WXG100 protein secretion system (Wss), protein YukC
M594_RS00665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M594_RS00670	COG0697	spore germination
M594_RS00685	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M594_RS00700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M594_RS00710	COG1132	(ABC) transporter
M594_RS00715	COG1132	(ABC) transporter
M594_RS00720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M594_RS00725	COG0166	Belongs to the GPI family
M594_RS00835	COG0534	Mate efflux family protein
M594_RS00840	COG0546	phosphoglycolate phosphatase activity
M594_RS00855	COG3759	membrane
M594_RS00860	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
M594_RS00890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M594_RS00895	COG1459	type II secretion system
M594_RS00900	COG4537	Required for transformation and DNA binding
M594_RS00925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M594_RS00945	COG0706	membrane insertase activity
M594_RS00950	COG1847	R3H domain protein
M594_RS00960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M594_RS00970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M594_RS00980	COG1012	belongs to the aldehyde dehydrogenase family
M594_RS00980	COG1454	alcohol dehydrogenase
M594_RS00990	COG1136	(ABC) transporter
M594_RS00995	COG0577	efflux transmembrane transporter activity
M594_RS01005	COG0564	pseudouridine synthase activity
M594_RS01010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M594_RS01015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M594_RS01115	COG2176	DNA-directed DNA polymerase activity
M594_RS01140	COG2309	aminopeptidase activity
M594_RS01145	COG2261	transglycosylase associated protein
M594_RS01150	COG1187	pseudouridine synthase activity
M594_RS01155	COG3579	cysteine-type endopeptidase activity
M594_RS01160	COG3716	PTS system mannose fructose sorbose family IID component
M594_RS01165	COG3715	PTS system
M594_RS01175	COG1064	alcohol dehydrogenase
M594_RS01180	COG0561	phosphatase activity
M594_RS01185	COG2252	PERMEase
M594_RS01195	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M594_RS01200	COG0285	dihydrofolate synthase activity
M594_RS01210	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M594_RS01210	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M594_RS01220	COG1609	Transcriptional regulator
M594_RS01225	COG0252	asparaginase activity
M594_RS01230	COG0561	phosphatase activity
M594_RS01235	COG0589	response to stress
M594_RS01245	COG0436	Aminotransferase
M594_RS01255	COG4166	transmembrane transport
M594_RS01260	COG0531	amino acid
M594_RS01265	COG0084	hydrolase, TatD family'
M594_RS01280	COG1162	GTPase activity
M594_RS01290	COG1564	THIamine pyrophosphokinase
M594_RS01300	COG3481	metal-dependent phosphohydrolase, HD sub domain
M594_RS01305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M594_RS01315	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
M594_RS01350	COG1254	Belongs to the acylphosphatase family
M594_RS01355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M594_RS01370	COG0742	ribosomal rna small subunit methyltransferase
M594_RS01380	COG3480	Lon protease (S16) C-terminal proteolytic domain
M594_RS01390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M594_RS01405	COG1253	flavin adenine dinucleotide binding
M594_RS01415	COG4166	transmembrane transport
M594_RS01420	COG0601	transmembrane transport
M594_RS01425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M594_RS01430	COG0444	Belongs to the ABC transporter superfamily
M594_RS01435	COG4608	Belongs to the ABC transporter superfamily
M594_RS01440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M594_RS01445	COG0569	domain protein
M594_RS01460	COG1122	ATPase activity
M594_RS01475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M594_RS01480	COG0671	phosphoesterase, PA-phosphatase related
M594_RS01490	COG1247	-acetyltransferase
M594_RS01500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M594_RS01500	COG0072	phenylalanine-tRNA ligase activity
M594_RS01505	COG4152	abc transporter atp-binding protein
M594_RS01510	COG1668	transmembrane transport
M594_RS01515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M594_RS01525	COG0582	viral genome integration into host DNA
M594_RS01530	COG1396	sequence-specific DNA binding
M594_RS01565	COG1051	belongs to the nudix hydrolase family
M594_RS01575	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M594_RS01585	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M594_RS01625	COG4555	ABC transporter
M594_RS01655	COG1122	ATPase activity
M594_RS01685	COG3620	sequence-specific DNA binding
M594_RS01690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M594_RS01710	COG0366	Alpha amylase catalytic
M594_RS01715	COG0386	Belongs to the glutathione peroxidase family
M594_RS01745	COG4839	cell division protein FtsL
M594_RS01750	COG0768	penicillin binding
M594_RS01780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M594_RS01810	COG1187	pseudouridine synthase activity
M594_RS01820	COG4607	ABC-type enterochelin transport system periplasmic component
M594_RS01830	COG4605	iron ion homeostasis
M594_RS01835	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M594_RS01840	COG1363	Peptidase, m42
M594_RS01850	COG1283	sodium-dependent phosphate transmembrane transporter activity
M594_RS01870	COG0789	Transcriptional regulator
M594_RS01875	COG0174	glutamine synthetase
M594_RS01905	COG0732	type I restriction modification DNA specificity domain
M594_RS01950	COG0484	heat shock protein binding
M594_RS01960	COG0537	adenosine 5'-monophosphoramidase activity
M594_RS01965	COG1131	(ABC) transporter
M594_RS01985	COG3290	protein histidine kinase activity
M594_RS02005	COG1266	CAAX protease self-immunity
M594_RS02025	COG0195	Participates in both transcription termination and antitermination
M594_RS02030	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M594_RS02080	COG0519	Catalyzes the synthesis of GMP from XMP
M594_RS02090	COG0525	valine-tRNA ligase activity
M594_RS02110	COG0504	CTP synthase activity
M594_RS02125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M594_RS02130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M594_RS02135	COG4221	oxidoreductase activity
M594_RS02175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M594_RS02290	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M594_RS02290	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M594_RS02310	COG1125	glycine betaine transport
M594_RS02310	COG0517	IMP dehydrogenase activity
M594_RS02315	COG1174	glycine betaine transport
M594_RS02325	COG1230	cation diffusion facilitator family transporter
M594_RS02330	COG1609	Transcriptional regulator
M594_RS02335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M594_RS02340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M594_RS02355	COG2233	PERMEase
M594_RS02370	COG0708	Exodeoxyribonuclease III
M594_RS02380	COG0640	Transcriptional regulator
M594_RS02400	COG1132	(ABC) transporter
M594_RS02405	COG1132	(ABC) transporter
M594_RS02410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M594_RS02415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M594_RS02420	COG0133	tryptophan synthase activity
M594_RS02425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M594_RS02430	COG0512	Glutamine amidotransferase of anthranilate synthase
M594_RS02445	COG0135	phosphoribosylanthranilate isomerase activity
M594_RS02460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M594_RS02480	COG0628	permease
M594_RS02500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M594_RS02515	COG1051	belongs to the nudix hydrolase family
M594_RS02525	COG2264	protein methyltransferase activity
M594_RS02530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M594_RS02535	COG1164	Oligoendopeptidase f
M594_RS02550	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M594_RS02565	COG0720	synthase
M594_RS02575	COG3118	belongs to the thioredoxin family
M594_RS02595	COG1346	cytolysis
M594_RS02625	COG1131	(ABC) transporter
M594_RS02630	COG1725	Transcriptional regulator
M594_RS02645	COG1484	DNA-dependent DNA replication
M594_RS02650	COG0778	Nitroreductase
M594_RS02675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M594_RS02680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
M594_RS02695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M594_RS02700	COG3458	cephalosporin-C deacetylase activity
M594_RS02720	COG1175	transmembrane transport
M594_RS02725	COG0395	ABC-type sugar transport system, permease component
M594_RS02730	COG2731	YhcH YjgK YiaL family protein
M594_RS02740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M594_RS02755	COG0768	penicillin binding
M594_RS02770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M594_RS02775	COG1051	belongs to the nudix hydrolase family
M594_RS02795	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M594_RS02815	COG3599	regulation of cell shape
M594_RS02830	COG3583	domain protein
M594_RS02830	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
M594_RS02840	COG0577	efflux transmembrane transporter activity
M594_RS02840	COG1136	(ABC) transporter
M594_RS02860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M594_RS02880	COG0204	Acyl-transferase
M594_RS02885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M594_RS02890	COG2384	SAM-dependent methyltransferase
M594_RS02895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M594_RS02900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M594_RS02905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M594_RS02910	COG0463	Glycosyl transferase, family 2
M594_RS02930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M594_RS02950	COG0251	oxidation-reduction process
M594_RS02960	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M594_RS02970	COG0492	ferredoxin-NADP+ reductase activity
M594_RS02975	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M594_RS02995	COG1307	EDD domain protein, DegV family
M594_RS03005	COG0617	tRNA 3'-terminal CCA addition
M594_RS03010	COG0488	(ABC) transporter
M594_RS03015	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M594_RS03025	COG0242	peptide deformylase activity
M594_RS03040	COG3711	transcriptional antiterminator
M594_RS03065	COG0436	Aminotransferase
M594_RS03070	COG0017	Asparaginyl-tRNA synthetase
M594_RS03085	COG0629	single-stranded DNA binding
M594_RS03090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M594_RS03105	COG1098	S1 RNA binding domain
M594_RS03110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M594_RS03115	COG2827	Endonuclease containing a URI domain
M594_RS03140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M594_RS03145	COG2244	polysaccharide biosynthetic process
M594_RS03150	COG4166	transmembrane transport
M594_RS03160	COG0626	cystathionine gamma-synthase activity
M594_RS03165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M594_RS03170	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M594_RS03195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M594_RS03205	COG1113	amino acid transport
M594_RS03215	COG1131	(ABC) transporter
M594_RS03235	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M594_RS03245	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M594_RS03250	COG0785	Cytochrome C biogenesis protein
M594_RS03255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M594_RS03260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M594_RS03260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M594_RS03265	COG4753	response regulator
M594_RS03265	COG2207	Transcriptional regulator
M594_RS03270	COG2972	Histidine kinase
M594_RS03280	COG3064	Membrane
M594_RS03305	COG1940	carbohydrate kinase activity
M594_RS03325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M594_RS03330	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M594_RS03340	COG0300	oxidoreductase activity
M594_RS03355	COG1242	4 iron, 4 sulfur cluster binding
M594_RS03360	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M594_RS03370	COG0025	NhaP-type Na H and K H
M594_RS03390	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M594_RS03415	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M594_RS03425	COG0647	UMP catabolic process
M594_RS03435	COG1393	Belongs to the ArsC family
M594_RS03445	COG0483	inositol monophosphate 1-phosphatase activity
M594_RS03450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M594_RS03450	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
M594_RS03455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M594_RS03460	COG0573	inorganic phosphate transmembrane transporter activity
M594_RS03465	COG0581	inorganic phosphate transmembrane transporter activity
M594_RS03470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M594_RS03475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M594_RS03480	COG0704	Plays a role in the regulation of phosphate uptake
M594_RS03485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M594_RS03490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M594_RS03495	COG3527	Alpha-acetolactate decarboxylase
M594_RS03510	COG3842	ATPase activity
M594_RS03530	COG1002	Type II restriction enzyme, methylase subunits
M594_RS03535	COG1061	Type III restriction enzyme res subunit
M594_RS03540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M594_RS03565	COG4555	ABC transporter
M594_RS03575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M594_RS03600	COG0287	Prephenate dehydrogenase
M594_RS03615	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M594_RS03620	COG0077	Prephenate dehydratase
M594_RS03630	COG3475	LICD family
M594_RS03635	COG1216	Glycosyl transferase, family 2
M594_RS03635	COG1442	glycosyl transferase family 8
M594_RS03640	COG3475	LICD family
M594_RS03645	COG3475	LICD family
M594_RS03675	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M594_RS03675	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M594_RS03680	COG1132	(ABC) transporter
M594_RS03690	COG0402	S-adenosylhomocysteine deaminase activity
M594_RS03695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M594_RS03725	COG1131	(ABC) transporter
M594_RS03745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M594_RS03750	COG0167	dihydroorotate dehydrogenase activity
M594_RS03760	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M594_RS03765	COG4470	Protein conserved in bacteria
M594_RS03770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M594_RS03780	COG0488	(ABC) transporter
M594_RS03835	COG1328	CTP reductase activity
M594_RS03835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M594_RS03845	COG4443	Transcriptional Coactivator p15 (PC4)
M594_RS03850	COG1268	BioY protein
M594_RS03855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M594_RS03860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M594_RS03865	COG1136	(ABC) transporter
M594_RS03870	COG0577	efflux transmembrane transporter activity
M594_RS03875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M594_RS03875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M594_RS03900	COG2813	Specifically methylates the guanine in position
M594_RS03905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M594_RS03915	COG0295	cytidine deaminase activity
M594_RS03920	COG1744	ABC transporter substrate-binding protein PnrA-like
M594_RS03950	COG0187	DNA topoisomerase II activity
M594_RS03975	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M594_RS03980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M594_RS04000	COG0539	negative regulation of cytoplasmic translation
M594_RS04005	COG1956	GAF domain-containing protein
M594_RS04010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M594_RS04025	COG0719	Fe-S assembly protein
M594_RS04030	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M594_RS04040	COG0719	Fe-S assembly protein
M594_RS04045	COG0531	amino acid
M594_RS04050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M594_RS04055	COG1307	EDD domain protein, DegV family
M594_RS04065	COG0039	L-malate dehydrogenase activity
M594_RS04070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M594_RS04075	COG3764	Sortase (surface protein transpeptidase)
M594_RS04110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M594_RS04135	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M594_RS04140	COG1438	arginine binding
M594_RS04145	COG0497	DNA recombination
M594_RS04150	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M594_RS04160	COG0758	DNA mediated transformation
M594_RS04165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M594_RS04170	COG2832	Protein of unknown function (DUF454)
M594_RS04175	COG3142	Participates in the control of copper homeostasis
M594_RS04190	COG0473	3-isopropylmalate dehydrogenase activity
M594_RS04215	COG1401	restriction endodeoxyribonuclease activity
M594_RS04235	COG2188	Transcriptional regulator
M594_RS04250	COG0356	it plays a direct role in the translocation of protons across the membrane
M594_RS04285	COG2706	6-phosphogluconolactonase activity
M594_RS04290	COG0628	permease
M594_RS04300	COG0765	amino acid transport
M594_RS04305	COG1126	abc transporter atp-binding protein
M594_RS04325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M594_RS04340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M594_RS04345	COG0494	nUDIX hydrolase
M594_RS04355	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M594_RS04365	COG2176	DNA-directed DNA polymerase activity
M594_RS04370	COG0584	glycerophosphoryl diester phosphodiesterase
M594_RS04435	COG1063	alcohol dehydrogenase
M594_RS04450	COG4750	Nucleotidyl transferase
M594_RS04465	COG3775	system Galactitol-specific IIC component
M594_RS04490	COG3684	Belongs to the aldolase LacD family
M594_RS04500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M594_RS04505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M594_RS04510	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M594_RS04515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M594_RS04525	COG3443	Belongs to the bacterial solute-binding protein 9 family
M594_RS04525	COG0803	Belongs to the bacterial solute-binding protein 9 family
M594_RS04540	COG3443	Belongs to the bacterial solute-binding protein 9 family
M594_RS04540	COG0803	Belongs to the bacterial solute-binding protein 9 family
M594_RS04550	COG2195	Cleaves the N-terminal amino acid of tripeptides
M594_RS04560	COG1970	mechanosensitive ion channel activity
M594_RS04570	COG4708	membrane
M594_RS04580	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M594_RS04590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M594_RS04595	COG1942	4-Oxalocrotonate Tautomerase
M594_RS04600	COG1435	thymidine kinase activity
M594_RS04610	COG2890	protein-(glutamine-N5) methyltransferase activity
M594_RS04635	COG0741	lytic transglycosylase activity
M594_RS04645	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M594_RS04660	COG0270	DNA (cytosine-5-)-methyltransferase activity
M594_RS04685	COG1737	Transcriptional regulator
M594_RS04690	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
M594_RS04695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M594_RS04700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M594_RS04715	COG0673	inositol 2-dehydrogenase activity
M594_RS04730	COG1269	ATP hydrolysis coupled proton transport
M594_RS04735	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M594_RS04830	COG1881	PFAM PEBP family protein
M594_RS04835	COG0583	DNA-binding transcription factor activity
M594_RS04955	COG1396	sequence-specific DNA binding
M594_RS04960	COG0542	response to heat
M594_RS05030	COG1131	(ABC) transporter
M594_RS05070	COG1597	lipid kinase activity
M594_RS05075	COG0135	phosphoribosylanthranilate isomerase activity
M594_RS05080	COG0366	Alpha amylase catalytic
M594_RS05105	COG1982	Orn Lys Arg decarboxylase major
M594_RS05110	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M594_RS05130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M594_RS05135	COG0745	RESPONSE REGULATOR receiver
M594_RS05140	COG2205	protein histidine kinase activity
M594_RS05150	COG1131	(ABC) transporter
M594_RS05155	COG0561	phosphatase activity
M594_RS05175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M594_RS05185	COG0489	protein tyrosine kinase activity
M594_RS05200	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M594_RS05205	COG0438	transferase activity, transferring glycosyl groups
M594_RS05215	COG1216	Glycosyl transferase, family 2
M594_RS05220	COG1215	transferase activity, transferring glycosyl groups
M594_RS05225	COG1216	Glycosyl transferase, family 2
M594_RS05230	COG1215	transferase activity, transferring glycosyl groups
M594_RS05250	COG0438	transferase activity, transferring glycosyl groups
M594_RS05265	COG0270	DNA (cytosine-5-)-methyltransferase activity
M594_RS05295	COG1131	(ABC) transporter
M594_RS05385	COG1881	PFAM PEBP family protein
M594_RS05400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M594_RS05405	COG0583	DNA-binding transcription factor activity
M594_RS05480	COG1131	(ABC) transporter
M594_RS05495	COG1396	sequence-specific DNA binding
M594_RS05500	COG0542	response to heat
M594_RS05515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M594_RS05545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M594_RS05570	COG3843	relaxase mobilization nuclease domain protein
M594_RS05580	COG1396	sequence-specific DNA binding
M594_RS05590	COG0535	radical SAM domain protein
M594_RS05610	COG1131	(ABC) transporter
M594_RS05615	COG1396	sequence-specific DNA binding
M594_RS05625	COG0582	viral genome integration into host DNA
M594_RS05630	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M594_RS05640	COG0038	chloride channel
M594_RS05660	COG0095	Lipoate-protein ligase
M594_RS05665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M594_RS05670	COG0508	dehydrogenase complex catalyzes the overall conversion of
M594_RS05675	COG0022	dehydrogenase e1 component
M594_RS05680	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M594_RS05685	COG0534	Mate efflux family protein
M594_RS05690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M594_RS05695	COG1051	belongs to the nudix hydrolase family
M594_RS05705	COG1011	Hydrolase
M594_RS05710	COG0556	nucleotide-excision repair
M594_RS05760	COG0560	Phosphoserine phosphatase
M594_RS05770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M594_RS05780	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M594_RS05785	COG1012	belongs to the aldehyde dehydrogenase family
M594_RS05790	COG1523	belongs to the glycosyl hydrolase 13 family
M594_RS05800	COG2814	Major facilitator Superfamily
M594_RS05810	COG0488	(ABC) transporter
M594_RS05815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M594_RS05825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M594_RS05835	COG0745	RESPONSE REGULATOR receiver
M594_RS05840	COG1194	a g-specific adenine glycosylase
M594_RS05845	COG0280	phosphate acetyltransferase
M594_RS05850	COG0564	pseudouridine synthase activity
M594_RS05860	COG2357	RelA SpoT domain protein
M594_RS05870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M594_RS05875	COG1104	cysteine desulfurase activity
M594_RS05895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M594_RS05915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M594_RS05920	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M594_RS05925	COG4684	Psort location CytoplasmicMembrane, score
M594_RS05935	COG1827	regulation of RNA biosynthetic process
M594_RS05945	COG1879	ABC-type sugar transport system periplasmic component
M594_RS05950	COG1172	Belongs to the binding-protein-dependent transport system permease family
M594_RS05960	COG1869	D-ribose catabolic process
M594_RS05965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M594_RS05970	COG1609	Transcriptional regulator
M594_RS05985	COG0556	nucleotide-excision repair
M594_RS05995	COG0765	amino acid transport
M594_RS06000	COG1126	abc transporter atp-binding protein
M594_RS06005	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M594_RS06010	COG0552	protein localization to endoplasmic reticulum
M594_RS06015	COG0561	phosphatase activity
M594_RS06020	COG0561	phosphatase activity
M594_RS06030	COG0577	efflux transmembrane transporter activity
M594_RS06035	COG1136	(ABC) transporter
M594_RS06060	COG2183	response to ionizing radiation
M594_RS06070	COG0701	Predicted permease
M594_RS06075	COG3689	TIGRFAM TIGR03943 family protein
M594_RS06090	COG0196	riboflavin kinase activity
M594_RS06095	COG1196	nuclear chromosome segregation
M594_RS06115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M594_RS06130	COG0628	permease
M594_RS06135	COG1686	Belongs to the peptidase S11 family
M594_RS06140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M594_RS06145	COG0785	Cytochrome C biogenesis protein
M594_RS06150	COG0024	Methionine aminopeptidase
M594_RS06155	COG4109	DRTGG domain
M594_RS06165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M594_RS06170	COG0469	pyruvate kinase activity
M594_RS06185	COG2936	dipeptidyl-peptidase activity
M594_RS06190	COG1438	arginine binding
M594_RS06210	COG1983	PspC domain protein
M594_RS06215	COG0438	transferase activity, transferring glycosyl groups
M594_RS06220	COG0438	transferase activity, transferring glycosyl groups
M594_RS06225	COG2151	metal-sulfur cluster biosynthetic enzyme
M594_RS06230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M594_RS06235	COG0358	DNA primase activity
M594_RS06240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M594_RS06255	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
M594_RS06260	COG0772	Belongs to the SEDS family
M594_RS06270	COG4122	O-methyltransferase activity
M594_RS06285	COG0500	methyltransferase
M594_RS06285	COG3615	Tellurite resistance protein tehB
M594_RS06295	COG0557	exoribonuclease II activity
M594_RS06305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M594_RS06310	COG2814	Major facilitator Superfamily
M594_RS06315	COG0237	dephospho-CoA kinase activity
M594_RS06320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M594_RS06330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M594_RS06340	COG1293	RNA-binding protein homologous to eukaryotic snRNP
M594_RS06355	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M594_RS06380	COG1136	(ABC) transporter
M594_RS06385	COG0577	efflux transmembrane transporter activity
M594_RS06395	COG5002	protein histidine kinase activity
M594_RS06400	COG0745	RESPONSE REGULATOR receiver
M594_RS06415	COG1028	Short-chain dehydrogenase reductase Sdr
M594_RS06425	COG4989	oxidoreductase activity
M594_RS06445	COG4193	domain, Protein
M594_RS06445	COG5263	repeat protein
M594_RS06450	COG0167	dihydroorotate dehydrogenase activity
M594_RS06455	COG0543	2 iron, 2 sulfur cluster binding
M594_RS06485	COG1131	(ABC) transporter
M594_RS06490	COG2333	competence protein COMEC
M594_RS06490	COG0658	competence protein
M594_RS06495	COG1555	photosystem II stabilization
M594_RS06495	COG1596	polysaccharide export
M594_RS06500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M594_RS06505	COG0686	Belongs to the AlaDH PNT family
M594_RS06510	COG1702	phosphate starvation-inducible protein PhoH
M594_RS06520	COG0456	acetyltransferase
M594_RS06520	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M594_RS06525	COG2996	Protein conserved in bacteria
M594_RS06535	COG0528	UMP kinase activity
M594_RS06555	COG0470	DNA polymerase III
M594_RS06565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M594_RS06580	COG0564	pseudouridine synthase activity
M594_RS06585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M594_RS06590	COG0583	DNA-binding transcription factor activity
M594_RS06625	COG0513	Belongs to the DEAD box helicase family
M594_RS06635	COG1078	dGTPase activity
M594_RS06655	COG1518	maintenance of DNA repeat elements
M594_RS06675	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M594_RS06680	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M594_RS06685	COG0077	Prephenate dehydratase
M594_RS06685	COG1605	Chorismate mutase
M594_RS06690	COG0716	FMN binding
M594_RS06695	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M594_RS06715	COG0505	Belongs to the CarA family
M594_RS06730	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M594_RS06745	COG0488	(ABC) transporter
M594_RS06755	COG1704	LemA family
M594_RS06775	COG0697	spore germination
M594_RS06780	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M594_RS06790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M594_RS06825	COG1104	cysteine desulfurase activity
M594_RS06835	COG0697	spore germination
M594_RS06835	COG1674	ftsk spoiiie
M594_RS06840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M594_RS06840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M594_RS06840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M594_RS06845	COG1105	Belongs to the carbohydrate kinase PfkB family
M594_RS06850	COG1349	DNA-binding transcription factor activity
M594_RS06860	COG1914	H( )-stimulated, divalent metal cation uptake system
M594_RS06875	COG0561	phosphatase activity
M594_RS06895	COG0492	ferredoxin-NADP+ reductase activity
M594_RS06905	COG1126	abc transporter atp-binding protein
M594_RS06915	COG1393	Belongs to the ArsC family
M594_RS06920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M594_RS06935	COG1272	protein, Hemolysin III
M594_RS06965	COG3976	FMN-binding domain protein
M594_RS06965	COG0431	NADPH-dependent FMN reductase
M594_RS06965	COG1053	succinate dehydrogenase
M594_RS06990	COG0726	polysaccharide deacetylase
M594_RS07000	COG0187	DNA topoisomerase II activity
M594_RS07010	COG0693	protein deglycase activity
M594_RS07015	COG0772	Belongs to the SEDS family
M594_RS07020	COG1199	ATP-dependent helicase activity
M594_RS07020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M594_RS07030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M594_RS07035	COG3250	beta-galactosidase activity
M594_RS07040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M594_RS07045	COG1126	abc transporter atp-binding protein
M594_RS07050	COG0765	amino acid transport
M594_RS07055	COG4703	Protein of unknown function (DUF1797)
M594_RS07060	COG0542	response to heat
M594_RS07085	COG0513	Belongs to the DEAD box helicase family
M594_RS07095	COG1263	PTS System
M594_RS07095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M594_RS07095	COG2190	(PTS) system
M594_RS07100	COG2177	Part of the ABC transporter FtsEX involved in
M594_RS07105	COG2884	Cell division ATP-binding protein ftsE
M594_RS07115	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M594_RS07115	COG0617	tRNA 3'-terminal CCA addition
M594_RS07115	COG0517	IMP dehydrogenase activity
M594_RS07130	COG4750	Nucleotidyl transferase
M594_RS07170	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M594_RS07175	COG2131	deaminase
M594_RS07185	COG1307	EDD domain protein, DegV family
M594_RS07190	COG2081	HI0933 family
M594_RS07200	COG0789	Transcriptional regulator
M594_RS07205	COG0733	neurotransmitter:sodium symporter activity
M594_RS07210	COG1482	cell wall glycoprotein biosynthetic process
M594_RS07215	COG2723	6-phospho-beta-galactosidase activity
M594_RS07235	COG0028	Belongs to the TPP enzyme family
M594_RS07240	COG2217	Heavy metal translocating P-type atpase
M594_RS07260	COG0352	thiamine-phosphate diphosphorylase activity
M594_RS07275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M594_RS07285	COG4172	Belongs to the ABC transporter superfamily
M594_RS07295	COG0352	thiamine-phosphate diphosphorylase activity
M594_RS07310	COG1304	FMN binding
M594_RS07325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M594_RS07340	COG1136	(ABC) transporter
M594_RS07360	COG1187	pseudouridine synthase activity
M594_RS07370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M594_RS07380	COG2197	response regulator
M594_RS07395	COG1136	(ABC) transporter
M594_RS07415	COG0583	DNA-binding transcription factor activity
M594_RS07420	COG0860	N-Acetylmuramoyl-L-alanine amidase
M594_RS07435	COG1404	Belongs to the peptidase S8 family
M594_RS07450	COG4555	ABC transporter
M594_RS07485	COG0191	fructose-bisphosphate aldolase activity
M594_RS07490	COG5002	protein histidine kinase activity
M594_RS07495	COG0745	RESPONSE REGULATOR receiver
M594_RS07500	COG0577	efflux transmembrane transporter activity
M594_RS07505	COG1136	(ABC) transporter
M594_RS07510	COG0577	efflux transmembrane transporter activity
M594_RS07520	COG1335	isochorismatase
M594_RS07525	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M594_RS07530	COG0513	Belongs to the DEAD box helicase family
M594_RS07535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M594_RS07540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M594_RS07545	COG3442	glutamine amidotransferase
M594_RS07550	COG0006	proline dipeptidase activity
M594_RS07555	COG4720	Psort location CytoplasmicMembrane, score
M594_RS07560	COG0351	phosphomethylpyrimidine kinase
M594_RS07580	COG2824	Alkylphosphonate utilization operon protein PhnA
M594_RS07600	COG3935	DnaD domain protein
M594_RS07615	COG2226	methyltransferase
M594_RS07640	COG1363	Peptidase, m42
M594_RS07645	COG1114	Component of the transport system for branched-chain amino acids
M594_RS07655	COG1573	uracil-dna glycosylase
M594_RS07700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M594_RS07700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M594_RS07710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M594_RS07715	COG0765	amino acid transport
M594_RS07720	COG0765	amino acid transport
M594_RS07725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M594_RS07730	COG1959	2 iron, 2 sulfur cluster binding
M594_RS07750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M594_RS07770	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M594_RS07775	COG5002	protein histidine kinase activity
M594_RS07780	COG0745	RESPONSE REGULATOR receiver
M594_RS07805	COG3590	peptidase
M594_RS07825	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M594_RS07860	COG3842	ATPase activity
M594_RS07870	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M594_RS07875	COG0215	cysteine-tRNA ligase activity
M594_RS07890	COG1045	serine acetyltransferase
M594_RS07905	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M594_RS07950	COG0732	type I restriction modification DNA specificity domain
M594_RS07975	COG1940	carbohydrate kinase activity
M594_RS07980	COG2190	(PTS) system
M594_RS07980	COG1263	PTS System
M594_RS07980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M594_RS07985	COG1621	beta-fructofuranosidase activity
M594_RS07990	COG1609	Transcriptional regulator
M594_RS08000	COG3425	synthase
M594_RS08015	COG0515	serine threonine protein kinase
M594_RS08015	COG2815	serine threonine protein kinase
M594_RS08020	COG0631	protein serine/threonine phosphatase activity
M594_RS08025	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M594_RS08025	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M594_RS08035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M594_RS08045	COG0194	GDP metabolic process
M594_RS08065	COG2226	methyltransferase
M594_RS08070	COG0799	negative regulation of ribosome biogenesis
M594_RS08075	COG1713	HD superfamily hydrolase involved in NAD metabolism
M594_RS08080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M594_RS08085	COG1534	Rna-binding protein
M594_RS08090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M594_RS08105	COG0668	transmembrane transport
M594_RS08110	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
M594_RS08130	COG0438	transferase activity, transferring glycosyl groups
M594_RS08135	COG0438	transferase activity, transferring glycosyl groups
M594_RS08140	COG0653	protein targeting
M594_RS08175	COG1442	glycosyl transferase family 8
M594_RS08180	COG1442	glycosyl transferase family 8
M594_RS08185	COG1442	glycosyl transferase family 8
M594_RS08190	COG1215	transferase activity, transferring glycosyl groups
M594_RS08215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
M594_RS08230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M594_RS08265	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M594_RS08270	COG0439	Biotin carboxylase
M594_RS08285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M594_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
M594_RS08295	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M594_RS08305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M594_RS08320	COG1024	Enoyl-CoA hydratase
M594_RS08325	COG0527	aspartate kinase activity
M594_RS08350	COG1115	amino acid carrier protein
M594_RS08375	COG0681	Belongs to the peptidase S26 family
M594_RS08380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M594_RS08395	COG2197	response regulator
M594_RS08400	COG4585	Histidine kinase
M594_RS08440	COG0745	RESPONSE REGULATOR receiver
M594_RS08445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M594_RS08455	COG0116	Belongs to the methyltransferase superfamily
M594_RS08490	COG0366	Alpha amylase catalytic
M594_RS08490	COG0366	Alpha amylase catalytic
M594_RS08490	COG0366	Alpha amylase catalytic
M594_RS08495	COG4166	transmembrane transport
M594_RS08500	COG0438	transferase activity, transferring glycosyl groups
M594_RS08505	COG0562	UDP-galactopyranose mutase
M594_RS08520	COG1442	glycosyl transferase family 8
M594_RS08520	COG1216	Glycosyl transferase, family 2
M594_RS08525	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M594_RS08530	COG0438	transferase activity, transferring glycosyl groups
M594_RS08535	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M594_RS08540	COG3475	LICD family
M594_RS08550	COG0489	protein tyrosine kinase activity
M594_RS08555	COG3944	biosynthesis protein
M594_RS08560	COG4464	protein tyrosine phosphatase activity
M594_RS08570	COG4166	transmembrane transport
M594_RS08575	COG4166	transmembrane transport
M594_RS08580	COG0366	Alpha amylase catalytic
M594_RS08600	COG1882	Formate acetyltransferase
M594_RS08605	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M594_RS08620	COG0765	amino acid transport
M594_RS08635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M594_RS08645	COG0440	acetolactate synthase activity
M594_RS08650	COG0028	Belongs to the TPP enzyme family
M594_RS08670	COG2197	response regulator
M594_RS08675	COG4585	Histidine kinase
M594_RS08680	COG0842	Transport permease protein
M594_RS08685	COG1131	(ABC) transporter
M594_RS08700	COG1461	Dihydroxyacetone kinase
M594_RS08710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M594_RS08735	COG3843	relaxase mobilization nuclease domain protein
M594_RS08785	COG3942	CHAP domain
M594_RS08785	COG1388	LysM domain
M594_RS08840	COG3620	sequence-specific DNA binding
M594_RS08875	COG1132	(ABC) transporter
M594_RS08910	COG1316	TRANSCRIPTIONal
M594_RS08915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M594_RS08920	COG0802	atpase or kinase
M594_RS08945	COG1523	belongs to the glycosyl hydrolase 13 family
M594_RS08955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M594_RS08960	COG2723	6-phospho-beta-galactosidase activity
M594_RS08970	COG0750	zinc metalloprotease
M594_RS08975	COG4589	Belongs to the CDS family
M594_RS08980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M594_RS09045	COG0745	RESPONSE REGULATOR receiver
M594_RS09050	COG2205	protein histidine kinase activity
M594_RS09090	COG2848	UPF0210 protein
M594_RS09095	COG3830	Belongs to the UPF0237 family
M594_RS09105	COG0202	RNA polymerase activity
M594_RS09110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M594_RS09120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M594_RS09125	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M594_RS09135	COG0201	protein transport
M594_RS09150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M594_RS09170	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M594_RS09190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M594_RS09215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M594_RS09245	COG0602	queuosine metabolic process
M594_RS09270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M594_RS09280	COG0285	dihydrofolate synthase activity
M594_RS09305	COG1393	Belongs to the ArsC family
M594_RS09310	COG0006	proline dipeptidase activity
M594_RS09315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M594_RS09340	COG2818	Glycosylase
M594_RS09370	COG1438	arginine binding
M594_RS09385	COG1780	Probably involved in ribonucleotide reductase function
M594_RS09400	COG2972	Histidine kinase
M594_RS09420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M594_RS09425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M594_RS09430	COG1464	Belongs to the NlpA lipoprotein family
M594_RS09435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M594_RS09475	COG1396	sequence-specific DNA binding
M594_RS09480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M594_RS09490	COG1214	PFAM Peptidase M22, glycoprotease
M594_RS09510	COG0445	tRNA wobble uridine modification
M594_RS09515	COG0494	nUDIX hydrolase
M594_RS09520	COG0494	nUDIX hydrolase
M594_RS09550	COG1388	LysM domain
M594_RS09550	COG1705	Flagellar rod assembly protein muramidase FlgJ
M594_RS09555	COG1760	l-serine dehydratase
M594_RS09560	COG1760	l-serine dehydratase
M594_RS09575	COG1216	Glycosyl transferase, family 2
M594_RS09590	COG1695	Transcriptional regulator
M594_RS09635	COG0395	ABC-type sugar transport system, permease component
M594_RS09640	COG4209	transmembrane transport
M594_RS09655	COG0383	alpha-mannosidase activity
M594_RS09665	COG3537	Alpha-1,2-mannosidase
M594_RS09675	COG1454	alcohol dehydrogenase
M594_RS09680	COG0803	Belongs to the bacterial solute-binding protein 9 family
M594_RS09680	COG3443	Belongs to the bacterial solute-binding protein 9 family
M594_RS09685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M594_RS09690	COG1121	(ABC) transporter
M594_RS09695	COG1846	Transcriptional regulator
M594_RS09705	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M594_RS09715	COG1696	Membrane protein involved in D-alanine export
M594_RS09730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M594_RS09735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M594_RS09755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M594_RS09775	COG3201	nicotinamide mononucleotide transporter
M594_RS09780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M594_RS09785	COG0542	response to heat
M594_RS09790	COG4463	regulation of RNA biosynthetic process
M594_RS09795	COG1116	anion transmembrane transporter activity
M594_RS09800	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M594_RS09805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M594_RS09815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M594_RS09815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M594_RS09835	COG0305	Participates in initiation and elongation during chromosome replication
M594_RS09855	COG1040	competence protein
M594_RS09860	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M594_RS09865	COG1739	Uncharacterized protein family UPF0029
M594_RS09890	COG3942	CHAP domain
M594_RS09900	COG1792	Involved in formation and maintenance of cell shape
M594_RS09905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M594_RS09910	COG1122	ATPase activity
M594_RS09915	COG1122	ATPase activity
M594_RS09920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M594_RS09930	COG0612	Peptidase, M16
M594_RS09935	COG0612	Peptidase, M16
M594_RS09940	COG2501	S4 domain
M594_RS09950	COG0517	IMP dehydrogenase activity
M594_RS09950	COG0516	GMP reductase activity
M594_RS09955	COG0180	Tryptophanyl-tRNA synthetase
M594_RS09960	COG0488	(ABC) transporter
M594_RS09970	COG1511	domain protein
M594_RS09970	COG1511	domain protein
M594_RS10015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M594_RS10020	COG1475	DNA binding