locus-tag	class	description
IGS65_RS00050	COG0527	aspartate kinase activity
IGS65_RS00060	COG1024	Enoyl-CoA hydratase
IGS65_RS00065	COG1846	Transcriptional regulator
IGS65_RS00070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS65_RS00085	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IGS65_RS00090	COG1028	Short-chain dehydrogenase reductase Sdr
IGS65_RS00095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS65_RS00105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IGS65_RS00110	COG0439	Biotin carboxylase
IGS65_RS00125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS65_RS00135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IGS65_RS00145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IGS65_RS00150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGS65_RS00155	COG0706	membrane insertase activity
IGS65_RS00160	COG1254	Belongs to the acylphosphatase family
IGS65_RS00165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IGS65_RS00180	COG0019	diaminopimelate decarboxylase activity
IGS65_RS00185	COG3763	UPF0154 protein
IGS65_RS00190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IGS65_RS00195	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IGS65_RS00210	COG0582	viral genome integration into host DNA
IGS65_RS00215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IGS65_RS00220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IGS65_RS00225	COG1187	pseudouridine synthase activity
IGS65_RS00230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IGS65_RS00235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IGS65_RS00240	COG0569	domain protein
IGS65_RS00265	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IGS65_RS00270	COG0671	phosphoesterase, PA-phosphatase related
IGS65_RS00280	COG1346	cytolysis
IGS65_RS00285	COG1242	4 iron, 4 sulfur cluster binding
IGS65_RS00290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IGS65_RS00295	COG1119	ATPase activity
IGS65_RS00300	COG0628	permease
IGS65_RS00305	COG1253	flavin adenine dinucleotide binding
IGS65_RS00310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IGS65_RS00320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS65_RS00325	COG1696	Membrane protein involved in D-alanine export
IGS65_RS00330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS65_RS00335	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IGS65_RS00340	COG1227	inorganic diphosphatase activity
IGS65_RS00350	COG2378	regulation of single-species biofilm formation
IGS65_RS00355	COG0693	protein deglycase activity
IGS65_RS00380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IGS65_RS00385	COG2244	polysaccharide biosynthetic process
IGS65_RS00390	COG0626	cystathionine gamma-synthase activity
IGS65_RS00395	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IGS65_RS00400	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IGS65_RS00405	COG0740	serine-type endopeptidase activity
IGS65_RS00415	COG4471	UPF0298 protein
IGS65_RS00425	COG0559	Belongs to the binding-protein-dependent transport system permease family
IGS65_RS00445	COG0517	IMP dehydrogenase activity
IGS65_RS00450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGS65_RS00455	COG0470	DNA polymerase III
IGS65_RS00460	COG1774	PSP1 C-terminal conserved region
IGS65_RS00465	COG4467	Involved in initiation control of chromosome replication
IGS65_RS00475	COG0004	ammonium transporteR
IGS65_RS00480	COG0347	Belongs to the P(II) protein family
IGS65_RS00485	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IGS65_RS00500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGS65_RS00505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGS65_RS00510	COG1393	Belongs to the ArsC family
IGS65_RS00515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IGS65_RS00520	COG0708	Exodeoxyribonuclease III
IGS65_RS00530	COG0640	Transcriptional regulator
IGS65_RS00570	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS65_RS00570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS65_RS00585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IGS65_RS00610	COG1674	ftsk spoiiie
IGS65_RS00620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IGS65_RS00625	COG0081	regulation of translation
IGS65_RS00630	COG0528	UMP kinase activity
IGS65_RS00635	COG0233	cytoplasmic translational termination
IGS65_RS00645	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS65_RS00650	COG4479	Belongs to the UPF0346 family
IGS65_RS00655	COG1702	phosphate starvation-inducible protein PhoH
IGS65_RS00660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IGS65_RS00665	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IGS65_RS00670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IGS65_RS00685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGS65_RS00690	COG0237	dephospho-CoA kinase activity
IGS65_RS00695	COG2814	Major facilitator Superfamily
IGS65_RS00700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGS65_RS00710	COG0557	exoribonuclease II activity
IGS65_RS00715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IGS65_RS00720	COG0346	lactoylglutathione lyase activity
IGS65_RS00725	COG0778	Nitroreductase
IGS65_RS00735	COG2723	6-phospho-beta-galactosidase activity
IGS65_RS00740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IGS65_RS00745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS65_RS00745	COG3711	transcriptional antiterminator
IGS65_RS00750	COG1447	Phosphotransferase system cellobiose-specific component IIA
IGS65_RS00760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IGS65_RS00780	COG1609	Transcriptional regulator
IGS65_RS00795	COG0438	transferase activity, transferring glycosyl groups
IGS65_RS00810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGS65_RS00820	COG4716	Myosin-crossreactive antigen
IGS65_RS00825	COG1956	GAF domain-containing protein
IGS65_RS00830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IGS65_RS00870	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IGS65_RS00875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGS65_RS00880	COG3842	ATPase activity
IGS65_RS00885	COG3833	ABC-type maltose transport systems, permease component
IGS65_RS00890	COG1175	transmembrane transport
IGS65_RS00900	COG1609	Transcriptional regulator
IGS65_RS00905	COG1640	4-alpha-glucanotransferase
IGS65_RS00910	COG0058	SHG alpha-glucan phosphorylase activity
IGS65_RS00915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IGS65_RS00920	COG0569	domain protein
IGS65_RS00940	COG4109	DRTGG domain
IGS65_RS00950	COG1295	ribonuclease BN
IGS65_RS00970	COG1131	(ABC) transporter
IGS65_RS00980	COG4585	Histidine kinase
IGS65_RS00985	COG2197	response regulator
IGS65_RS00995	COG4708	membrane
IGS65_RS01000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS65_RS01005	COG1597	lipid kinase activity
IGS65_RS01010	COG1523	belongs to the glycosyl hydrolase 13 family
IGS65_RS01015	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGS65_RS01020	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IGS65_RS01025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IGS65_RS01030	COG0297	glycogen (starch) synthase activity
IGS65_RS01035	COG0058	SHG alpha-glucan phosphorylase activity
IGS65_RS01045	COG0356	it plays a direct role in the translocation of protons across the membrane
IGS65_RS01050	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IGS65_RS01055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS65_RS01060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IGS65_RS01065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IGS65_RS01070	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IGS65_RS01075	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IGS65_RS01085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGS65_RS01100	COG0765	amino acid transport
IGS65_RS01105	COG0765	amino acid transport
IGS65_RS01110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS65_RS01120	COG0745	RESPONSE REGULATOR receiver
IGS65_RS01125	COG5002	protein histidine kinase activity
IGS65_RS01130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IGS65_RS01135	COG0571	ribonuclease III activity
IGS65_RS01140	COG1196	nuclear chromosome segregation
IGS65_RS01145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IGS65_RS01155	COG0072	phenylalanine-tRNA ligase activity
IGS65_RS01155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS65_RS01170	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IGS65_RS01175	COG1074	ATP-dependent DNA helicase activity
IGS65_RS01180	COG1349	DNA-binding transcription factor activity
IGS65_RS01185	COG0698	ribose 5-phosphate isomerase
IGS65_RS01190	COG0698	ribose 5-phosphate isomerase
IGS65_RS01195	COG1105	Belongs to the carbohydrate kinase PfkB family
IGS65_RS01200	COG3684	Belongs to the aldolase LacD family
IGS65_RS01215	COG3775	system Galactitol-specific IIC component
IGS65_RS01220	COG1447	Phosphotransferase system cellobiose-specific component IIA
IGS65_RS01225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IGS65_RS01225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IGS65_RS01230	COG2723	6-phospho-beta-galactosidase activity
IGS65_RS01285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IGS65_RS01290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IGS65_RS01300	COG1234	tRNA 3'-trailer cleavage
IGS65_RS01305	COG0300	oxidoreductase activity
IGS65_RS01310	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IGS65_RS01310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IGS65_RS01315	COG2378	regulation of single-species biofilm formation
IGS65_RS01335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IGS65_RS01340	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IGS65_RS01350	COG2384	SAM-dependent methyltransferase
IGS65_RS01360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS65_RS01365	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IGS65_RS01380	COG1088	dTDP-glucose 4,6-dehydratase activity
IGS65_RS01385	COG1051	belongs to the nudix hydrolase family
IGS65_RS01390	COG0628	permease
IGS65_RS01400	COG0028	Belongs to the TPP enzyme family
IGS65_RS01405	COG3527	Alpha-acetolactate decarboxylase
IGS65_RS01410	COG1113	amino acid transport
IGS65_RS01415	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IGS65_RS01430	COG3842	ATPase activity
IGS65_RS01450	COG4808	Protein conserved in bacteria
IGS65_RS01460	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IGS65_RS01475	COG1215	transferase activity, transferring glycosyl groups
IGS65_RS01485	COG0488	(ABC) transporter
IGS65_RS01495	COG3442	glutamine amidotransferase
IGS65_RS01500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IGS65_RS01505	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IGS65_RS01515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS65_RS01520	COG0542	response to heat
IGS65_RS01530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IGS65_RS01535	COG0022	dehydrogenase e1 component
IGS65_RS01540	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS65_RS01545	COG2249	NAD(P)H dehydrogenase (quinone) activity
IGS65_RS01555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IGS65_RS01565	COG1051	belongs to the nudix hydrolase family
IGS65_RS01570	COG0647	UMP catabolic process
IGS65_RS01580	COG0577	efflux transmembrane transporter activity
IGS65_RS01580	COG1136	(ABC) transporter
IGS65_RS01590	COG1053	succinate dehydrogenase
IGS65_RS01590	COG3976	FMN-binding domain protein
IGS65_RS01605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IGS65_RS01620	COG0481	GTPase activity
IGS65_RS01645	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IGS65_RS01655	COG0673	inositol 2-dehydrogenase activity
IGS65_RS01660	COG0572	uridine kinase
IGS65_RS01670	COG0473	3-isopropylmalate dehydrogenase activity
IGS65_RS01675	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IGS65_RS01680	COG0066	3-isopropylmalate dehydratase activity
IGS65_RS01695	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IGS65_RS01695	COG0456	acetyltransferase
IGS65_RS01705	COG2813	Specifically methylates the guanine in position
IGS65_RS01715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IGS65_RS01725	COG2884	Cell division ATP-binding protein ftsE
IGS65_RS01730	COG2177	Part of the ABC transporter FtsEX involved in
IGS65_RS01760	COG1122	ATPase activity
IGS65_RS01770	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IGS65_RS01770	COG1199	ATP-dependent helicase activity
IGS65_RS01775	COG0436	Aminotransferase
IGS65_RS01780	COG0017	Asparaginyl-tRNA synthetase
IGS65_RS01785	COG0371	Dehydrogenase
IGS65_RS01790	COG0251	oxidation-reduction process
IGS65_RS01800	COG1660	Displays ATPase and GTPase activities
IGS65_RS01810	COG1481	regulation of sporulation
IGS65_RS01825	COG2226	methyltransferase
IGS65_RS01840	COG0254	rRNA binding
IGS65_RS01845	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IGS65_RS01850	COG0625	glutathione transferase activity
IGS65_RS01855	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IGS65_RS01860	COG0716	FMN binding
IGS65_RS01875	COG1605	Chorismate mutase
IGS65_RS01875	COG0077	Prephenate dehydratase
IGS65_RS01880	COG0038	chloride channel
IGS65_RS01885	COG0038	chloride channel
IGS65_RS01890	COG0335	large ribosomal subunit rRNA binding
IGS65_RS01900	COG2814	Major facilitator Superfamily
IGS65_RS01925	COG0772	Belongs to the SEDS family
IGS65_RS01940	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IGS65_RS01955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS65_RS01960	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IGS65_RS01965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IGS65_RS01970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IGS65_RS01975	COG0560	Phosphoserine phosphatase
IGS65_RS01980	COG0131	Imidazoleglycerol-phosphate dehydratase
IGS65_RS01990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IGS65_RS01995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IGS65_RS02000	COG0107	imidazoleglycerol-phosphate synthase activity
IGS65_RS02005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IGS65_RS02040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS65_RS02040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IGS65_RS02090	COG0148	phosphopyruvate hydratase activity
IGS65_RS02100	COG1011	Hydrolase
IGS65_RS02110	COG0322	excinuclease ABC activity
IGS65_RS02120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS65_RS02125	COG1573	uracil-dna glycosylase
IGS65_RS02145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IGS65_RS02150	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IGS65_RS02155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IGS65_RS02185	COG0813	purine-nucleoside phosphorylase activity
IGS65_RS02200	COG0543	2 iron, 2 sulfur cluster binding
IGS65_RS02205	COG0167	dihydroorotate dehydrogenase activity
IGS65_RS02210	COG0284	orotidine-5'-phosphate decarboxylase activity
IGS65_RS02215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IGS65_RS02220	COG1881	PFAM PEBP family protein
IGS65_RS02225	COG2315	Protein conserved in bacteria
IGS65_RS02235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS65_RS02240	COG0765	amino acid transport
IGS65_RS02245	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IGS65_RS02255	COG0737	Belongs to the 5'-nucleotidase family
IGS65_RS02260	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IGS65_RS02265	COG0187	DNA topoisomerase II activity
IGS65_RS02285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IGS65_RS02305	COG0539	negative regulation of cytoplasmic translation
IGS65_RS02335	COG1131	(ABC) transporter
IGS65_RS02340	COG1725	Transcriptional regulator
IGS65_RS02350	COG0205	6-phosphofructokinase activity
IGS65_RS02355	COG0469	pyruvate kinase activity
IGS65_RS02360	COG2261	transglycosylase associated protein
IGS65_RS02370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS65_RS02375	COG2213	PTS system mannitol-specific
IGS65_RS02380	COG3711	transcriptional antiterminator
IGS65_RS02385	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS65_RS02390	COG0246	Mannitol dehydrogenase
IGS65_RS02395	COG2824	Alkylphosphonate utilization operon protein PhnA
IGS65_RS02400	COG0765	amino acid transport
IGS65_RS02405	COG1126	abc transporter atp-binding protein
IGS65_RS02410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS65_RS02415	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IGS65_RS02420	COG1115	amino acid carrier protein
IGS65_RS02425	COG0210	DNA helicase
IGS65_RS02430	COG2873	o-acetylhomoserine
IGS65_RS02445	COG0785	Cytochrome C biogenesis protein
IGS65_RS02450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS65_RS02475	COG1132	(ABC) transporter
IGS65_RS02475	COG2375	cellular response to nickel ion
IGS65_RS02480	COG1132	(ABC) transporter
IGS65_RS02545	COG0745	RESPONSE REGULATOR receiver
IGS65_RS02550	COG2205	protein histidine kinase activity
IGS65_RS02555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IGS65_RS02560	COG0196	riboflavin kinase activity
IGS65_RS02565	COG1393	Belongs to the ArsC family
IGS65_RS02570	COG4476	Belongs to the UPF0223 family
IGS65_RS02575	COG0483	inositol monophosphate 1-phosphatase activity
IGS65_RS02580	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
IGS65_RS02580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IGS65_RS02590	COG0573	inorganic phosphate transmembrane transporter activity
IGS65_RS02595	COG0581	inorganic phosphate transmembrane transporter activity
IGS65_RS02600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGS65_RS02605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGS65_RS02610	COG0704	Plays a role in the regulation of phosphate uptake
IGS65_RS02625	COG0745	RESPONSE REGULATOR receiver
IGS65_RS02630	COG5002	protein histidine kinase activity
IGS65_RS02635	COG0268	Binds directly to 16S ribosomal RNA
IGS65_RS02640	COG1072	(Pantothenic acid kinase))
IGS65_RS02645	COG2813	Specifically methylates the guanine in position
IGS65_RS02650	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IGS65_RS02655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IGS65_RS02660	COG0295	cytidine deaminase activity
IGS65_RS02665	COG1744	ABC transporter substrate-binding protein PnrA-like
IGS65_RS02670	COG3845	ABC transporter
IGS65_RS02675	COG4603	Belongs to the binding-protein-dependent transport system permease family
IGS65_RS02680	COG1079	Belongs to the binding-protein-dependent transport system permease family
IGS65_RS02695	COG0039	L-malate dehydrogenase activity
IGS65_RS02705	COG3764	Sortase (surface protein transpeptidase)
IGS65_RS02710	COG0346	lactoylglutathione lyase activity
IGS65_RS02725	COG0561	phosphatase activity
IGS65_RS02740	COG0406	alpha-ribazole phosphatase activity
IGS65_RS02750	COG2723	6-phospho-beta-galactosidase activity
IGS65_RS02755	COG0628	permease
IGS65_RS02760	COG1063	alcohol dehydrogenase
IGS65_RS02775	COG1174	glycine betaine transport
IGS65_RS02780	COG1136	(ABC) transporter
IGS65_RS02785	COG0577	efflux transmembrane transporter activity
IGS65_RS02795	COG3976	FMN-binding domain protein
IGS65_RS02795	COG0431	NADPH-dependent FMN reductase
IGS65_RS02795	COG1053	succinate dehydrogenase
IGS65_RS02810	COG1942	4-Oxalocrotonate Tautomerase
IGS65_RS02815	COG1435	thymidine kinase activity
IGS65_RS02820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IGS65_RS02825	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS65_RS02830	COG0009	L-threonylcarbamoyladenylate synthase
IGS65_RS02835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS65_RS02850	COG1132	(ABC) transporter
IGS65_RS02855	COG1132	(ABC) transporter
IGS65_RS02860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS65_RS02865	COG4684	Psort location CytoplasmicMembrane, score
IGS65_RS02870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IGS65_RS02880	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IGS65_RS02890	COG1247	-acetyltransferase
IGS65_RS02910	COG1131	(ABC) transporter
IGS65_RS02920	COG0519	Catalyzes the synthesis of GMP from XMP
IGS65_RS02925	COG2188	Transcriptional regulator
IGS65_RS02935	COG4175	Glycine betaine
IGS65_RS02935	COG3448	diguanylate cyclase activity
IGS65_RS02945	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IGS65_RS02950	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IGS65_RS02975	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IGS65_RS02980	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IGS65_RS02990	COG1104	cysteine desulfurase activity
IGS65_RS02995	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IGS65_RS03000	COG4116	CYTH
IGS65_RS03010	COG2357	RelA SpoT domain protein
IGS65_RS03015	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IGS65_RS03020	COG0564	pseudouridine synthase activity
IGS65_RS03025	COG0280	phosphate acetyltransferase
IGS65_RS03035	COG1131	(ABC) transporter
IGS65_RS03040	COG4221	oxidoreductase activity
IGS65_RS03045	COG1442	glycosyl transferase family 8
IGS65_RS03050	COG0745	RESPONSE REGULATOR receiver
IGS65_RS03055	COG5002	protein histidine kinase activity
IGS65_RS03065	COG1131	(ABC) transporter
IGS65_RS03070	COG4974	Belongs to the 'phage' integrase family
IGS65_RS03145	COG3052	prosthetic group binding
IGS65_RS03150	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
IGS65_RS03155	COG0511	ligase activity, forming carbon-carbon bonds
IGS65_RS03165	COG2851	Citrate transporter
IGS65_RS03175	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
IGS65_RS03180	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
IGS65_RS03185	COG0642	Histidine kinase
IGS65_RS03190	COG0745	RESPONSE REGULATOR receiver
IGS65_RS03200	COG1136	(ABC) transporter
IGS65_RS03205	COG0366	Alpha amylase catalytic
IGS65_RS03205	COG5263	repeat protein
IGS65_RS03210	COG0366	Alpha amylase catalytic
IGS65_RS03210	COG5263	repeat protein
IGS65_RS03215	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IGS65_RS03220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IGS65_RS03225	COG0758	DNA mediated transformation
IGS65_RS03235	COG4607	ABC-type enterochelin transport system periplasmic component
IGS65_RS03240	COG4604	ABC transporter, ATP-binding protein
IGS65_RS03245	COG4605	iron ion homeostasis
IGS65_RS03250	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS65_RS03255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IGS65_RS03260	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IGS65_RS03275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS65_RS03280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IGS65_RS03290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGS65_RS03295	COG4932	domain protein
IGS65_RS03325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IGS65_RS03325	COG2190	(PTS) system
IGS65_RS03325	COG1263	PTS System
IGS65_RS03330	COG3711	transcriptional antiterminator
IGS65_RS03340	COG1177	transmembrane transport
IGS65_RS03345	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS65_RS03350	COG3842	ATPase activity
IGS65_RS03355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IGS65_RS03375	COG0302	gtp cyclohydrolase
IGS65_RS03380	COG0285	dihydrofolate synthase activity
IGS65_RS03385	COG0083	homoserine kinase activity
IGS65_RS03395	COG0726	polysaccharide deacetylase
IGS65_RS03400	COG1960	acyl-CoA dehydrogenase activity
IGS65_RS03410	COG0222	ribosome binding
IGS65_RS03415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IGS65_RS03435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS65_RS03440	COG2040	homocysteine
IGS65_RS03445	COG0833	amino acid
IGS65_RS03450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IGS65_RS03455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IGS65_RS03465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IGS65_RS03470	COG3201	nicotinamide mononucleotide transporter
IGS65_RS03475	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IGS65_RS03480	COG3425	synthase
IGS65_RS03495	COG1272	protein, Hemolysin III
IGS65_RS03505	COG1304	FMN binding
IGS65_RS03520	COG1126	abc transporter atp-binding protein
IGS65_RS03525	COG0765	amino acid transport
IGS65_RS03530	COG0765	amino acid transport
IGS65_RS03535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS65_RS03545	COG0583	DNA-binding transcription factor activity
IGS65_RS03560	COG0745	RESPONSE REGULATOR receiver
IGS65_RS03565	COG2357	RelA SpoT domain protein
IGS65_RS03575	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IGS65_RS03580	COG1132	(ABC) transporter
IGS65_RS03595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IGS65_RS03605	COG0602	queuosine metabolic process
IGS65_RS03610	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IGS65_RS03620	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IGS65_RS03630	COG0366	Alpha amylase catalytic
IGS65_RS03630	COG5263	repeat protein
IGS65_RS03640	COG1132	(ABC) transporter
IGS65_RS03650	COG0488	(ABC) transporter
IGS65_RS03655	COG0617	tRNA 3'-terminal CCA addition
IGS65_RS03660	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IGS65_RS03665	COG1307	EDD domain protein, DegV family
IGS65_RS03680	COG1131	(ABC) transporter
IGS65_RS03700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IGS65_RS03705	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IGS65_RS03710	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IGS65_RS03715	COG1609	Transcriptional regulator
IGS65_RS03720	COG0366	Alpha amylase catalytic
IGS65_RS03725	COG3842	ATPase activity
IGS65_RS03730	COG0366	Alpha amylase catalytic
IGS65_RS03735	COG0395	ABC-type sugar transport system, permease component
IGS65_RS03740	COG1175	transmembrane transport
IGS65_RS03745	COG1653	transport
IGS65_RS03750	COG3345	alpha-galactosidase
IGS65_RS03755	COG2207	Transcriptional regulator
IGS65_RS03765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IGS65_RS03765	COG0646	methionine synthase
IGS65_RS03770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IGS65_RS03775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS65_RS03775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS65_RS03775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS65_RS03780	COG1105	Belongs to the carbohydrate kinase PfkB family
IGS65_RS03785	COG1349	DNA-binding transcription factor activity
IGS65_RS03790	COG0492	ferredoxin-NADP+ reductase activity
IGS65_RS03795	COG0336	Belongs to the RNA methyltransferase TrmD family
IGS65_RS03800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IGS65_RS03805	COG1837	Belongs to the UPF0109 family
IGS65_RS03810	COG0228	four-way junction DNA binding
IGS65_RS03815	COG0577	efflux transmembrane transporter activity
IGS65_RS03820	COG1136	(ABC) transporter
IGS65_RS03830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IGS65_RS03835	COG0505	Belongs to the CarA family
IGS65_RS03840	COG0540	Belongs to the ATCase OTCase family
IGS65_RS03850	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IGS65_RS03860	COG0564	pseudouridine synthase activity
IGS65_RS03865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IGS65_RS03870	COG0583	DNA-binding transcription factor activity
IGS65_RS03875	COG2816	NAD+ diphosphatase activity
IGS65_RS03885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IGS65_RS03895	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IGS65_RS03915	COG0301	tRNA thio-modification
IGS65_RS03920	COG1104	cysteine desulfurase activity
IGS65_RS03930	COG0285	dihydrofolate synthase activity
IGS65_RS03935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS65_RS03940	COG0656	L-ascorbic acid biosynthetic process
IGS65_RS03945	COG3942	CHAP domain
IGS65_RS03960	COG0463	Glycosyl transferase, family 2
IGS65_RS03970	COG1368	sulfuric ester hydrolase activity
IGS65_RS03995	COG1215	transferase activity, transferring glycosyl groups
IGS65_RS04005	COG1091	dTDP-4-dehydrorhamnose reductase activity
IGS65_RS04010	COG2151	metal-sulfur cluster biosynthetic enzyme
IGS65_RS04015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS65_RS04020	COG0358	DNA primase activity
IGS65_RS04030	COG1970	mechanosensitive ion channel activity
IGS65_RS04040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS65_RS04050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS65_RS04075	COG0556	nucleotide-excision repair
IGS65_RS04090	COG1126	abc transporter atp-binding protein
IGS65_RS04095	COG0488	(ABC) transporter
IGS65_RS04105	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IGS65_RS04155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IGS65_RS04165	COG0077	Prephenate dehydratase
IGS65_RS04170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IGS65_RS04175	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IGS65_RS04180	COG3679	Belongs to the UPF0342 family
IGS65_RS04185	COG0287	Prephenate dehydrogenase
IGS65_RS04190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IGS65_RS04195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IGS65_RS04200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGS65_RS04205	COG0710	3-dehydroquinate dehydratase activity
IGS65_RS04210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IGS65_RS04215	COG1368	sulfuric ester hydrolase activity
IGS65_RS04225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IGS65_RS04230	COG0366	Alpha amylase catalytic
IGS65_RS04230	COG5263	repeat protein
IGS65_RS04235	COG1914	H( )-stimulated, divalent metal cation uptake system
IGS65_RS04240	COG4443	Transcriptional Coactivator p15 (PC4)
IGS65_RS04255	COG0450	alkyl hydroperoxide reductase
IGS65_RS04260	COG0826	peptidase U32
IGS65_RS04285	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IGS65_RS04290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IGS65_RS04300	COG3091	SprT-like family
IGS65_RS04305	COG2183	response to ionizing radiation
IGS65_RS04315	COG0701	Predicted permease
IGS65_RS04320	COG3689	TIGRFAM TIGR03943 family protein
IGS65_RS04325	COG0477	Major facilitator Superfamily
IGS65_RS04330	COG0552	protein localization to endoplasmic reticulum
IGS65_RS04335	COG0561	phosphatase activity
IGS65_RS04340	COG0561	phosphatase activity
IGS65_RS04395	COG0604	alcohol dehydrogenase
IGS65_RS04410	COG0584	glycerophosphoryl diester phosphodiesterase
IGS65_RS04430	COG1078	dGTPase activity
IGS65_RS04450	COG0149	triose-phosphate isomerase activity
IGS65_RS04460	COG2274	protein secretion by the type I secretion system
IGS65_RS04490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGS65_RS04495	COG0772	Belongs to the SEDS family
IGS65_RS04500	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IGS65_RS04520	COG3859	Proton-coupled thiamine transporter YuaJ
IGS65_RS04535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IGS65_RS04545	COG0588	phosphoglycerate mutase activity
IGS65_RS04550	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IGS65_RS04555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IGS65_RS04560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IGS65_RS04565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IGS65_RS04585	COG2195	Cleaves the N-terminal amino acid of tripeptides
IGS65_RS04610	COG0656	L-ascorbic acid biosynthetic process
IGS65_RS04615	COG0656	L-ascorbic acid biosynthetic process
IGS65_RS04620	COG0789	Transcriptional regulator
IGS65_RS04625	COG1012	belongs to the aldehyde dehydrogenase family
IGS65_RS04630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IGS65_RS04635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS65_RS04645	COG0538	isocitrate dehydrogenase activity
IGS65_RS04650	COG0372	Belongs to the citrate synthase family
IGS65_RS04655	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IGS65_RS04660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IGS65_RS04665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS65_RS04670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS65_RS04675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGS65_RS04680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IGS65_RS04685	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IGS65_RS04690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IGS65_RS04740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IGS65_RS04750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGS65_RS04755	COG4122	O-methyltransferase activity
IGS65_RS04760	COG0131	Imidazoleglycerol-phosphate dehydratase
IGS65_RS04760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IGS65_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
IGS65_RS04790	COG3321	synthase
IGS65_RS04790	COG0604	alcohol dehydrogenase
IGS65_RS04795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS65_RS04805	COG1187	pseudouridine synthase activity
IGS65_RS04815	COG0363	glucosamine-6-phosphate deaminase activity
IGS65_RS04825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IGS65_RS04850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IGS65_RS04865	COG2333	competence protein COMEC
IGS65_RS04865	COG0658	competence protein
IGS65_RS04870	COG1596	polysaccharide export
IGS65_RS04870	COG1555	photosystem II stabilization
IGS65_RS04875	COG0204	Acyl-transferase
IGS65_RS04880	COG0726	polysaccharide deacetylase
IGS65_RS04890	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IGS65_RS04930	COG0513	Belongs to the DEAD box helicase family
IGS65_RS04935	COG3064	Membrane
IGS65_RS04935	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IGS65_RS04945	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IGS65_RS04955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IGS65_RS04960	COG0385	Bile acid
IGS65_RS04970	COG1181	Belongs to the D-alanine--D-alanine ligase family
IGS65_RS04975	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IGS65_RS04980	COG0768	penicillin binding
IGS65_RS04985	COG0588	phosphoglycerate mutase activity
IGS65_RS05000	COG0735	belongs to the Fur family
IGS65_RS05015	COG2801	Transposase and inactivated derivatives
IGS65_RS05020	COG0776	regulation of translation
IGS65_RS05030	COG2755	lipolytic protein G-D-S-L family
IGS65_RS05035	COG1307	EDD domain protein, DegV family
IGS65_RS05040	COG0497	DNA recombination
IGS65_RS05045	COG1438	arginine binding
IGS65_RS05050	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IGS65_RS05060	COG1722	exodeoxyribonuclease VII activity
IGS65_RS05065	COG1570	exodeoxyribonuclease VII activity
IGS65_RS05070	COG3275	phosphorelay sensor kinase activity
IGS65_RS05075	COG3279	Response regulator of the LytR AlgR family
IGS65_RS05080	COG1380	Effector of murein hydrolase LrgA
IGS65_RS05085	COG1346	cytolysis
IGS65_RS05090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IGS65_RS05095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IGS65_RS05115	COG1126	abc transporter atp-binding protein
IGS65_RS05120	COG0765	amino acid transport
IGS65_RS05125	COG4703	Protein of unknown function (DUF1797)
IGS65_RS05130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGS65_RS05135	COG0542	response to heat
IGS65_RS05150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IGS65_RS05155	COG3599	regulation of cell shape
IGS65_RS05160	COG2302	S4 RNA-binding domain
IGS65_RS05170	COG1799	cell septum assembly
IGS65_RS05175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IGS65_RS05195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGS65_RS05200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IGS65_RS05210	COG1217	gtp-binding protein TYPA
IGS65_RS05215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IGS65_RS05220	COG1940	carbohydrate kinase activity
IGS65_RS05230	COG0783	Belongs to the Dps family
IGS65_RS05240	COG0159	tryptophan synthase activity
IGS65_RS05245	COG0133	tryptophan synthase activity
IGS65_RS05250	COG0135	phosphoribosylanthranilate isomerase activity
IGS65_RS05255	COG0134	indole-3-glycerol-phosphate synthase activity
IGS65_RS05260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IGS65_RS05265	COG0512	Glutamine amidotransferase of anthranilate synthase
IGS65_RS05270	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IGS65_RS05290	COG3804	dihydrodipicolinate reductase
IGS65_RS05300	COG1132	(ABC) transporter
IGS65_RS05305	COG1132	(ABC) transporter
IGS65_RS05315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IGS65_RS05320	COG4470	Protein conserved in bacteria
IGS65_RS05325	COG0737	Belongs to the 5'-nucleotidase family
IGS65_RS05330	COG3480	Lon protease (S16) C-terminal proteolytic domain
IGS65_RS05335	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IGS65_RS05340	COG0742	ribosomal rna small subunit methyltransferase
IGS65_RS05345	COG4716	Myosin-crossreactive antigen
IGS65_RS05380	COG0561	phosphatase activity
IGS65_RS05385	COG1349	DNA-binding transcription factor activity
IGS65_RS05430	COG1040	competence protein
IGS65_RS05435	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IGS65_RS05440	COG1739	Uncharacterized protein family UPF0029
IGS65_RS05460	COG1882	Formate acetyltransferase
IGS65_RS05465	COG1349	DNA-binding transcription factor activity
IGS65_RS05470	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IGS65_RS05475	COG1098	S1 RNA binding domain
IGS65_RS05485	COG2197	response regulator
IGS65_RS05490	COG4585	Histidine kinase
IGS65_RS05510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IGS65_RS05510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS65_RS05515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IGS65_RS05520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IGS65_RS05525	COG1758	RNA polymerase activity
IGS65_RS05530	COG0194	GDP metabolic process
IGS65_RS05535	COG4372	Transposase
IGS65_RS05535	COG1418	mRNA catabolic process
IGS65_RS05540	COG1854	S-ribosylhomocysteine lyase activity
IGS65_RS05550	COG0116	Belongs to the methyltransferase superfamily
IGS65_RS05560	COG3599	regulation of cell shape
IGS65_RS05565	COG4474	Belongs to the UPF0398 family
IGS65_RS05570	COG3331	DNA recombination
IGS65_RS05575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS65_RS05580	COG3579	cysteine-type endopeptidase activity
IGS65_RS05585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IGS65_RS05590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IGS65_RS05595	COG0492	ferredoxin-NADP+ reductase activity
IGS65_RS05605	COG1126	abc transporter atp-binding protein
IGS65_RS05620	COG0513	Belongs to the DEAD box helicase family
IGS65_RS05625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS65_RS05630	COG0768	penicillin binding
IGS65_RS05635	COG4839	cell division protein FtsL
IGS65_RS05640	COG0275	rRNA processing
IGS65_RS05645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IGS65_RS05650	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IGS65_RS05660	COG4224	UPF0291 protein
IGS65_RS05665	COG0751	glycine-tRNA ligase activity
IGS65_RS05670	COG0752	glycyl-tRNA synthetase alpha subunit
IGS65_RS05675	COG1673	EVE domain
IGS65_RS05695	COG1924	4 iron, 4 sulfur cluster binding
IGS65_RS05720	COG1131	(ABC) transporter
IGS65_RS05730	COG0561	phosphatase activity
IGS65_RS05740	COG2217	Heavy metal translocating P-type atpase
IGS65_RS05755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IGS65_RS05760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IGS65_RS05770	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IGS65_RS05775	COG0195	Participates in both transcription termination and antitermination
IGS65_RS05780	COG0779	Required for maturation of 30S ribosomal subunits
IGS65_RS05790	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IGS65_RS05800	COG4473	ABC transporter
IGS65_RS05805	COG1131	(ABC) transporter
IGS65_RS05810	COG0537	adenosine 5'-monophosphoramidase activity
IGS65_RS05820	COG1316	TRANSCRIPTIONal
IGS65_RS05825	COG0802	atpase or kinase
IGS65_RS05830	COG2252	PERMEase
IGS65_RS05840	COG0561	phosphatase activity
IGS65_RS05855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IGS65_RS05860	COG1882	Formate acetyltransferase
IGS65_RS05870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IGS65_RS05885	COG2936	dipeptidyl-peptidase activity
IGS65_RS05890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IGS65_RS05895	COG1733	regulation of RNA biosynthetic process
IGS65_RS05900	COG0778	Nitroreductase
IGS65_RS05910	COG2081	HI0933 family
IGS65_RS05930	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IGS65_RS05935	COG0456	acetyltransferase
IGS65_RS05940	COG1214	PFAM Peptidase M22, glycoprotease
IGS65_RS05950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS65_RS05955	COG0667	Aldo Keto reductase
IGS65_RS05980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS65_RS05995	COG2226	methyltransferase
IGS65_RS06015	COG5503	Protein of unknown function (DUF1447)
IGS65_RS06025	COG3942	CHAP domain
IGS65_RS06030	COG0493	'glutamate synthase
IGS65_RS06035	COG0070	glutamate synthase
IGS65_RS06035	COG0067	glutamate synthase
IGS65_RS06035	COG0069	glutamate synthase activity
IGS65_RS06040	COG0174	glutamine synthetase
IGS65_RS06045	COG0789	Transcriptional regulator
IGS65_RS06055	COG0126	phosphoglycerate kinase activity
IGS65_RS06065	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGS65_RS06070	COG0049	tRNA binding
IGS65_RS06075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IGS65_RS06080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IGS65_RS06105	COG1162	GTPase activity
IGS65_RS06125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IGS65_RS06160	COG0084	hydrolase, TatD family'
IGS65_RS06165	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IGS65_RS06180	COG0706	membrane insertase activity
IGS65_RS06185	COG0594	ribonuclease P activity
IGS65_RS06190	COG0165	Argininosuccinate lyase
IGS65_RS06195	COG0137	argininosuccinate synthase activity
IGS65_RS06215	COG1827	regulation of RNA biosynthetic process
IGS65_RS06220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS65_RS06245	COG0756	dUTP diphosphatase activity
IGS65_RS06250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IGS65_RS06255	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IGS65_RS06260	COG0457	Tetratricopeptide repeat
IGS65_RS06260	COG0705	Rhomboid family
IGS65_RS06265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IGS65_RS06270	COG1473	amidohydrolase
IGS65_RS06275	COG2171	N-acyltransferase activity
IGS65_RS06290	COG3732	PTS system glucitol sorbitol-specific
IGS65_RS06295	COG3730	PTS system glucitol sorbitol-specific
IGS65_RS06305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS65_RS06305	COG3711	transcriptional antiterminator
IGS65_RS06315	COG0166	Belongs to the GPI family
IGS65_RS06335	COG1234	tRNA 3'-trailer cleavage
IGS65_RS06350	COG0343	queuine tRNA-ribosyltransferase activity
IGS65_RS06360	COG1832	CoA-binding protein
IGS65_RS06365	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS65_RS06365	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS65_RS06380	COG0583	DNA-binding transcription factor activity
IGS65_RS06420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
IGS65_RS06430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IGS65_RS06450	COG2274	protein secretion by the type I secretion system
IGS65_RS06490	COG3623	hexulose-6-phosphate isomerase
IGS65_RS06500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS65_RS06510	COG3037	sugar-specific permease SgaT UlaA
IGS65_RS06515	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IGS65_RS06520	COG1181	Belongs to the D-alanine--D-alanine ligase family
IGS65_RS06520	COG2918	glutathione biosynthetic process
IGS65_RS06530	COG4608	Belongs to the ABC transporter superfamily
IGS65_RS06535	COG0444	Belongs to the ABC transporter superfamily
IGS65_RS06540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS65_RS06545	COG0601	transmembrane transport
IGS65_RS06550	COG4166	transmembrane transport
IGS65_RS06565	COG0719	Fe-S assembly protein
IGS65_RS06575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS65_RS06580	COG0719	Fe-S assembly protein
IGS65_RS06590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS65_RS06595	COG4862	establishment of competence for transformation
IGS65_RS06600	COG1968	undecaprenyl-diphosphatase activity
IGS65_RS06610	COG0765	amino acid transport
IGS65_RS06615	COG1126	abc transporter atp-binding protein
IGS65_RS06625	COG1131	(ABC) transporter
IGS65_RS06635	COG1309	transcriptional regulator
IGS65_RS06645	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS65_RS06650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IGS65_RS06655	COG0440	acetolactate synthase activity
IGS65_RS06660	COG0028	Belongs to the TPP enzyme family
IGS65_RS06690	COG2801	Transposase and inactivated derivatives
IGS65_RS06695	COG2801	Transposase and inactivated derivatives
IGS65_RS06800	COG0203	ribosomal protein L17
IGS65_RS06805	COG0202	RNA polymerase activity
IGS65_RS06810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IGS65_RS06815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IGS65_RS06825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IGS65_RS06830	COG0563	adenylate kinase activity
IGS65_RS06835	COG0201	protein transport
IGS65_RS06840	COG0200	Binds to the 23S rRNA
IGS65_RS06845	COG1841	ribosomal large subunit assembly
IGS65_RS06850	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IGS65_RS06860	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IGS65_RS06865	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IGS65_RS06870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IGS65_RS06875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IGS65_RS06880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IGS65_RS06885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IGS65_RS06890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IGS65_RS06895	COG0255	Belongs to the universal ribosomal protein uL29 family
IGS65_RS06900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IGS65_RS06905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IGS65_RS06910	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IGS65_RS06920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IGS65_RS06925	COG0089	rRNA binding
IGS65_RS06935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IGS65_RS06940	COG0051	transcription antitermination factor activity, RNA binding
IGS65_RS06950	COG1621	beta-fructofuranosidase activity
IGS65_RS06955	COG0542	response to heat
IGS65_RS06960	COG4463	regulation of RNA biosynthetic process
IGS65_RS06965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IGS65_RS06970	COG0052	Belongs to the universal ribosomal protein uS2 family
IGS65_RS06985	COG1619	proteins homologs of microcin C7 resistance protein MccF
IGS65_RS06990	COG3590	peptidase
IGS65_RS06995	COG0366	Alpha amylase catalytic
IGS65_RS07000	COG1263	PTS System
IGS65_RS07000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IGS65_RS07005	COG2188	Transcriptional regulator
IGS65_RS07010	COG5297	Belongs to the glycosyl hydrolase family 6
IGS65_RS07015	COG1490	D-aminoacyl-tRNA deacylase activity
IGS65_RS07030	COG1263	PTS System
IGS65_RS07030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IGS65_RS07030	COG2190	(PTS) system
IGS65_RS07040	COG1609	Transcriptional regulator
IGS65_RS07045	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IGS65_RS07050	COG2264	protein methyltransferase activity
IGS65_RS07070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IGS65_RS07085	COG2217	Heavy metal translocating P-type atpase
IGS65_RS07095	COG2855	membrane
IGS65_RS07100	COG0583	DNA-binding transcription factor activity
IGS65_RS07110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IGS65_RS07120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IGS65_RS07130	COG0463	Glycosyl transferase, family 2
IGS65_RS07135	COG0428	transporter
IGS65_RS07140	COG3022	response to hydroperoxide
IGS65_RS07165	COG3906	Belongs to the UPF0473 family
IGS65_RS07170	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IGS65_RS07175	COG4472	Bacterial protein of unknown function (DUF965)
IGS65_RS07200	COG1393	Belongs to the ArsC family
IGS65_RS07205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IGS65_RS07210	COG1058	Belongs to the CinA family
IGS65_RS07210	COG1546	Belongs to the CinA family
IGS65_RS07215	COG0519	Catalyzes the synthesis of GMP from XMP
IGS65_RS07220	COG0632	four-way junction helicase activity
IGS65_RS07225	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IGS65_RS07235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IGS65_RS07245	COG1438	arginine binding
IGS65_RS07265	COG0018	arginyl-trna synthetase
IGS65_RS07270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IGS65_RS07275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IGS65_RS07280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IGS65_RS07285	COG0124	histidyl-tRNA synthetase
IGS65_RS07290	COG0531	amino acid
IGS65_RS07295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IGS65_RS07300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGS65_RS07315	COG0640	Transcriptional regulator
IGS65_RS07375	COG0789	Transcriptional regulator
IGS65_RS07380	COG1028	Short-chain dehydrogenase reductase Sdr
IGS65_RS07405	COG2094	Belongs to the DNA glycosylase MPG family
IGS65_RS07420	COG1733	regulation of RNA biosynthetic process
IGS65_RS07430	COG1012	belongs to the aldehyde dehydrogenase family
IGS65_RS07435	COG0129	dihydroxy-acid dehydratase activity
IGS65_RS07440	COG2151	metal-sulfur cluster biosynthetic enzyme
IGS65_RS07460	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IGS65_RS07470	COG0305	Participates in initiation and elongation during chromosome replication
IGS65_RS07475	COG0359	binds to the 23S rRNA
IGS65_RS07485	COG0445	tRNA wobble uridine modification
IGS65_RS07495	COG0482	sulfurtransferase activity
IGS65_RS07500	COG0741	lytic transglycosylase activity
IGS65_RS07510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IGS65_RS07515	COG1122	ATPase activity
IGS65_RS07520	COG1122	ATPase activity
IGS65_RS07525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IGS65_RS07535	COG0612	Peptidase, M16
IGS65_RS07550	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IGS65_RS07555	COG0517	IMP dehydrogenase activity
IGS65_RS07555	COG0516	GMP reductase activity
IGS65_RS07560	COG0180	Tryptophanyl-tRNA synthetase
IGS65_RS07565	COG0488	(ABC) transporter
IGS65_RS07595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IGS65_RS07600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS65_RS07605	COG1475	DNA binding
IGS65_RS07610	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IGS65_RS07615	COG0592	DNA-directed DNA polymerase activity
IGS65_RS07625	COG0012	GTP binding
IGS65_RS07630	COG0193	aminoacyl-tRNA hydrolase activity
IGS65_RS07635	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IGS65_RS07640	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IGS65_RS07660	COG0037	tRNA processing
IGS65_RS07665	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IGS65_RS07670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IGS65_RS07675	COG0531	amino acid
IGS65_RS07785	COG1792	Involved in formation and maintenance of cell shape
IGS65_RS07795	COG3942	CHAP domain
IGS65_RS07800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IGS65_RS07805	COG0436	Aminotransferase
IGS65_RS07810	COG1381	Involved in DNA repair and RecF pathway recombination
IGS65_RS07815	COG0416	fatty acid biosynthetic process
IGS65_RS07820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS65_RS07825	COG2274	protein secretion by the type I secretion system
IGS65_RS07830	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IGS65_RS07835	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS65_RS07840	COG4335	DNA alkylation repair
IGS65_RS07845	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IGS65_RS07850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IGS65_RS07855	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IGS65_RS07865	COG0138	bifunctional purine biosynthesis protein purh
IGS65_RS07905	COG0151	Belongs to the GarS family
IGS65_RS07915	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IGS65_RS07930	COG1794	racemase activity, acting on amino acids and derivatives
IGS65_RS07950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGS65_RS07970	COG2255	four-way junction helicase activity
IGS65_RS07975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS65_RS07995	COG0534	Mate efflux family protein
IGS65_RS08000	COG3830	Belongs to the UPF0237 family
IGS65_RS08005	COG2848	UPF0210 protein
IGS65_RS08020	COG1705	Flagellar rod assembly protein muramidase FlgJ
IGS65_RS08025	COG3583	domain protein
IGS65_RS08025	COG5492	domain, Protein
IGS65_RS08025	COG1621	beta-fructofuranosidase activity
IGS65_RS08035	COG1420	regulation of RNA biosynthetic process
IGS65_RS08040	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IGS65_RS08050	COG0443	Heat shock 70 kDa protein
IGS65_RS08055	COG0484	heat shock protein binding
IGS65_RS08060	COG0101	tRNA pseudouridine synthase activity
IGS65_RS08065	COG0351	phosphomethylpyrimidine kinase
IGS65_RS08070	COG4720	Psort location CytoplasmicMembrane, score
IGS65_RS08075	COG4475	Protein of unknown function (DUF436)
IGS65_RS08080	COG0668	transmembrane transport
IGS65_RS08090	COG0544	peptidyl-prolyl cis-trans isomerase activity
IGS65_RS08100	COG2226	methyltransferase
IGS65_RS08105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IGS65_RS08110	COG1854	S-ribosylhomocysteine lyase activity
IGS65_RS08115	COG0697	spore germination
IGS65_RS08120	COG1959	2 iron, 2 sulfur cluster binding
IGS65_RS08155	COG3343	RNA polymerase activity
IGS65_RS08160	COG0504	CTP synthase activity
IGS65_RS08180	COG1396	sequence-specific DNA binding
IGS65_RS08215	COG0191	fructose-bisphosphate aldolase activity
IGS65_RS08230	COG1105	Belongs to the carbohydrate kinase PfkB family
IGS65_RS08235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS65_RS08235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS65_RS08235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS65_RS08240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS65_RS08240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IGS65_RS08240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS65_RS08245	COG3684	Belongs to the aldolase LacD family
IGS65_RS08265	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IGS65_RS08270	COG0534	Mate efflux family protein
IGS65_RS08275	COG2176	DNA-directed DNA polymerase activity
IGS65_RS08280	COG1846	Transcriptional regulator
IGS65_RS08285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IGS65_RS08290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IGS65_RS08295	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS65_RS08295	COG0022	dehydrogenase e1 component
IGS65_RS08310	COG0095	Lipoate-protein ligase
IGS65_RS08325	COG2856	Zn peptidase
IGS65_RS08335	COG1473	amidohydrolase
IGS65_RS08340	COG0477	Major facilitator Superfamily
IGS65_RS08345	COG1309	transcriptional regulator
IGS65_RS08350	COG0583	DNA-binding transcription factor activity
IGS65_RS08360	COG0281	malic enzyme
IGS65_RS08365	COG0679	Auxin Efflux Carrier
IGS65_RS08370	COG2140	Oxalate decarboxylase
IGS65_RS08385	COG0242	peptide deformylase activity
IGS65_RS08390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS65_RS08400	COG1454	alcohol dehydrogenase
IGS65_RS08400	COG1012	belongs to the aldehyde dehydrogenase family
IGS65_RS08405	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IGS65_RS08410	COG1185	polyribonucleotide nucleotidyltransferase activity
IGS65_RS08420	COG1045	serine acetyltransferase
IGS65_RS08425	COG0215	cysteine-tRNA ligase activity
IGS65_RS08430	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IGS65_RS08435	COG5504	Zn-dependent protease
IGS65_RS08455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IGS65_RS08475	COG1476	TRANSCRIPTIONal
IGS65_RS08480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IGS65_RS08485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IGS65_RS08530	COG3321	synthase
IGS65_RS08530	COG1028	Short-chain dehydrogenase reductase Sdr
IGS65_RS08530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IGS65_RS08530	COG4221	oxidoreductase activity
IGS65_RS08535	COG1122	ATPase activity
IGS65_RS08555	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IGS65_RS08575	COG2801	Transposase and inactivated derivatives
IGS65_RS08580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IGS65_RS08590	COG0431	NADPH-dependent FMN reductase
IGS65_RS08590	COG1053	succinate dehydrogenase
IGS65_RS08590	COG3976	FMN-binding domain protein
IGS65_RS08595	COG3976	FMN-binding domain protein
IGS65_RS08595	COG1053	succinate dehydrogenase
IGS65_RS08595	COG0431	NADPH-dependent FMN reductase
IGS65_RS08600	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IGS65_RS08615	COG0803	Belongs to the bacterial solute-binding protein 9 family
IGS65_RS08625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IGS65_RS08630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IGS65_RS08665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IGS65_RS08675	COG1121	(ABC) transporter
IGS65_RS08680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IGS65_RS08685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IGS65_RS08690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS65_RS08695	COG0085	RNA polymerase activity
IGS65_RS08700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IGS65_RS08710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IGS65_RS08715	COG1459	type II secretion system
IGS65_RS08745	COG0827	DNA restriction-modification system
IGS65_RS08750	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IGS65_RS08770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IGS65_RS08775	COG1363	Peptidase, m42
IGS65_RS08785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS65_RS08790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS65_RS08795	COG1846	Transcriptional regulator
IGS65_RS08815	COG4585	Histidine kinase
IGS65_RS08820	COG2197	response regulator
IGS65_RS08845	COG3715	PTS system
IGS65_RS08850	COG3716	PTS system mannose fructose sorbose family IID component
IGS65_RS08860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IGS65_RS08865	COG0459	protein refolding
IGS65_RS08875	COG0564	pseudouridine synthase activity
IGS65_RS08880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS65_RS08910	COG0495	leucyl-tRNA aminoacylation
IGS65_RS08915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS65_RS08920	COG1464	Belongs to the NlpA lipoprotein family
IGS65_RS08925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS65_RS08930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IGS65_RS08940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS65_RS08950	COG4720	Psort location CytoplasmicMembrane, score
IGS65_RS08955	COG1122	ATPase activity
IGS65_RS08965	COG0357	Ribosomal RNA small subunit methyltransferase G
IGS65_RS08970	COG1704	LemA family
IGS65_RS08975	COG0501	Belongs to the peptidase M48B family
IGS65_RS08980	COG4591	ABC-type transport system involved in lipoprotein release permease component
IGS65_RS08985	COG1136	(ABC) transporter
IGS65_RS09000	COG0745	RESPONSE REGULATOR receiver
IGS65_RS09005	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGS65_RS09015	COG1484	DNA-dependent DNA replication
IGS65_RS09020	COG1160	GTP binding
IGS65_RS09030	COG0586	Pfam SNARE associated Golgi protein
IGS65_RS09060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IGS65_RS09080	COG2274	protein secretion by the type I secretion system
IGS65_RS09085	COG3716	PTS system mannose fructose sorbose family IID component
IGS65_RS09090	COG3715	PTS system
IGS65_RS09105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IGS65_RS09110	COG0681	Belongs to the peptidase S26 family
IGS65_RS09115	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IGS65_RS09130	COG1193	negative regulation of DNA recombination
IGS65_RS09135	COG3118	belongs to the thioredoxin family
IGS65_RS09140	COG1063	alcohol dehydrogenase
IGS65_RS09145	COG1194	a g-specific adenine glycosylase
IGS65_RS09155	COG0360	Binds together with S18 to 16S ribosomal RNA
IGS65_RS09160	COG0629	single-stranded DNA binding
IGS65_RS09165	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IGS65_RS09200	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS65_RS09205	COG0006	proline dipeptidase activity
IGS65_RS09210	COG2131	deaminase
IGS65_RS09215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS65_RS09220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IGS65_RS09230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS65_RS09235	COG1609	Transcriptional regulator
IGS65_RS09240	COG1621	beta-fructofuranosidase activity
IGS65_RS09245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IGS65_RS09245	COG2190	(PTS) system
IGS65_RS09245	COG1263	PTS System
IGS65_RS09250	COG1940	carbohydrate kinase activity
IGS65_RS09255	COG1482	cell wall glycoprotein biosynthetic process
IGS65_RS09260	COG0653	protein targeting
IGS65_RS09265	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IGS65_RS09270	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IGS65_RS09275	COG0736	holo-[acyl-carrier-protein] synthase activity
IGS65_RS09280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IGS65_RS09285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IGS65_RS09295	COG0252	asparaginase activity
IGS65_RS09300	COG0561	phosphatase activity
IGS65_RS09310	COG1268	BioY protein
IGS65_RS09315	COG0436	Aminotransferase
IGS65_RS09320	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IGS65_RS09325	COG1335	isochorismatase
IGS65_RS09330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IGS65_RS09335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS65_RS09340	COG0154	amidase activity
IGS65_RS09345	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS65_RS09355	COG1819	glycosyl
IGS65_RS09370	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IGS65_RS09375	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IGS65_RS09380	COG1534	Rna-binding protein
IGS65_RS09385	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IGS65_RS09390	COG1713	HD superfamily hydrolase involved in NAD metabolism
IGS65_RS09395	COG0799	negative regulation of ribosome biogenesis
IGS65_RS09400	COG2226	methyltransferase
IGS65_RS09415	COG1323	Belongs to the UPF0348 family
IGS65_RS09420	COG0789	Transcriptional regulator
IGS65_RS09425	COG0217	transcriptional regulatory protein
IGS65_RS09435	COG1862	Preprotein translocase
IGS65_RS09440	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IGS65_RS09445	COG4589	Belongs to the CDS family
IGS65_RS09455	COG0442	prolyl-tRNA aminoacylation
IGS65_RS09515	COG3557	Belongs to the UPF0374 family
IGS65_RS09520	COG2137	regulation of response to DNA damage stimulus
IGS65_RS09525	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IGS65_RS09530	COG1780	Probably involved in ribonucleotide reductase function
IGS65_RS09590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGS65_RS09595	COG0525	valine-tRNA ligase activity
IGS65_RS09600	COG0232	Belongs to the dGTPase family. Type 2 subfamily