locus-tag	class	description
I6L88_RS00005	COG0085	RNA polymerase activity
I6L88_RS00010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6L88_RS00020	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6L88_RS00025	COG1459	type II secretion system
I6L88_RS00055	COG0827	DNA restriction-modification system
I6L88_RS00060	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6L88_RS00080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6L88_RS00085	COG1363	Peptidase, m42
I6L88_RS00095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L88_RS00100	COG0072	phenylalanine-tRNA ligase activity
I6L88_RS00100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L88_RS00105	COG1846	Transcriptional regulator
I6L88_RS00125	COG4585	Histidine kinase
I6L88_RS00130	COG2197	response regulator
I6L88_RS00155	COG3715	PTS system
I6L88_RS00160	COG3716	PTS system mannose fructose sorbose family IID component
I6L88_RS00170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6L88_RS00175	COG0459	protein refolding
I6L88_RS00185	COG0564	pseudouridine synthase activity
I6L88_RS00190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L88_RS00220	COG0495	leucyl-tRNA aminoacylation
I6L88_RS00225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L88_RS00230	COG1464	Belongs to the NlpA lipoprotein family
I6L88_RS00235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L88_RS00240	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6L88_RS00250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6L88_RS00260	COG4720	Psort location CytoplasmicMembrane, score
I6L88_RS00265	COG1122	ATPase activity
I6L88_RS00275	COG0357	Ribosomal RNA small subunit methyltransferase G
I6L88_RS00280	COG1704	LemA family
I6L88_RS00285	COG0501	Belongs to the peptidase M48B family
I6L88_RS00290	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6L88_RS00295	COG1136	(ABC) transporter
I6L88_RS00310	COG0745	RESPONSE REGULATOR receiver
I6L88_RS00315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6L88_RS00325	COG1484	DNA-dependent DNA replication
I6L88_RS00330	COG1160	GTP binding
I6L88_RS00340	COG0586	Pfam SNARE associated Golgi protein
I6L88_RS00350	COG3290	protein histidine kinase activity
I6L88_RS00415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6L88_RS00430	COG3716	PTS system mannose fructose sorbose family IID component
I6L88_RS00435	COG3715	PTS system
I6L88_RS00450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6L88_RS00455	COG0681	Belongs to the peptidase S26 family
I6L88_RS00460	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L88_RS00475	COG1193	negative regulation of DNA recombination
I6L88_RS00480	COG3118	belongs to the thioredoxin family
I6L88_RS00485	COG1063	alcohol dehydrogenase
I6L88_RS00490	COG1194	a g-specific adenine glycosylase
I6L88_RS00505	COG0360	Binds together with S18 to 16S ribosomal RNA
I6L88_RS00510	COG0629	single-stranded DNA binding
I6L88_RS00515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6L88_RS00550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6L88_RS00555	COG0006	proline dipeptidase activity
I6L88_RS00560	COG2131	deaminase
I6L88_RS00565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L88_RS00570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6L88_RS00580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L88_RS00585	COG1609	Transcriptional regulator
I6L88_RS00590	COG1621	beta-fructofuranosidase activity
I6L88_RS00595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L88_RS00595	COG2190	(PTS) system
I6L88_RS00595	COG1263	PTS System
I6L88_RS00600	COG1940	carbohydrate kinase activity
I6L88_RS00605	COG1482	cell wall glycoprotein biosynthetic process
I6L88_RS00610	COG0653	protein targeting
I6L88_RS00615	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L88_RS00620	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6L88_RS00625	COG0736	holo-[acyl-carrier-protein] synthase activity
I6L88_RS00630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6L88_RS00635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6L88_RS00645	COG0252	asparaginase activity
I6L88_RS00650	COG0561	phosphatase activity
I6L88_RS00660	COG1268	BioY protein
I6L88_RS00665	COG0436	Aminotransferase
I6L88_RS00670	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6L88_RS00675	COG1335	isochorismatase
I6L88_RS00680	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L88_RS00685	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L88_RS00690	COG0154	amidase activity
I6L88_RS00695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6L88_RS00700	COG0697	spore germination
I6L88_RS00710	COG1309	transcriptional regulator
I6L88_RS00720	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6L88_RS00725	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6L88_RS00730	COG1534	Rna-binding protein
I6L88_RS00735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6L88_RS00740	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6L88_RS00745	COG0799	negative regulation of ribosome biogenesis
I6L88_RS00750	COG2226	methyltransferase
I6L88_RS00765	COG1323	Belongs to the UPF0348 family
I6L88_RS00770	COG0789	Transcriptional regulator
I6L88_RS00775	COG0217	transcriptional regulatory protein
I6L88_RS00785	COG1862	Preprotein translocase
I6L88_RS00790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6L88_RS00795	COG4589	Belongs to the CDS family
I6L88_RS00805	COG0442	prolyl-tRNA aminoacylation
I6L88_RS00865	COG3557	Belongs to the UPF0374 family
I6L88_RS00870	COG2137	regulation of response to DNA damage stimulus
I6L88_RS00875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L88_RS00880	COG1780	Probably involved in ribonucleotide reductase function
I6L88_RS00920	COG0525	valine-tRNA ligase activity
I6L88_RS00970	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6L88_RS01045	COG0527	aspartate kinase activity
I6L88_RS01050	COG0546	phosphoglycolate phosphatase activity
I6L88_RS01055	COG1024	Enoyl-CoA hydratase
I6L88_RS01060	COG1846	Transcriptional regulator
I6L88_RS01065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6L88_RS01080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6L88_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
I6L88_RS01090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6L88_RS01100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6L88_RS01105	COG0439	Biotin carboxylase
I6L88_RS01120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6L88_RS01130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6L88_RS01140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6L88_RS01145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6L88_RS01150	COG0706	membrane insertase activity
I6L88_RS01155	COG1254	Belongs to the acylphosphatase family
I6L88_RS01160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L88_RS01175	COG0019	diaminopimelate decarboxylase activity
I6L88_RS01180	COG3763	UPF0154 protein
I6L88_RS01185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6L88_RS01190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6L88_RS01205	COG0582	viral genome integration into host DNA
I6L88_RS01210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6L88_RS01215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6L88_RS01220	COG1187	pseudouridine synthase activity
I6L88_RS01225	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6L88_RS01230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6L88_RS01235	COG0569	domain protein
I6L88_RS01260	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I6L88_RS01265	COG0671	phosphoesterase, PA-phosphatase related
I6L88_RS01275	COG1346	cytolysis
I6L88_RS01280	COG1242	4 iron, 4 sulfur cluster binding
I6L88_RS01285	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6L88_RS01290	COG1119	ATPase activity
I6L88_RS01295	COG0628	permease
I6L88_RS01300	COG1253	flavin adenine dinucleotide binding
I6L88_RS01305	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L88_RS01315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6L88_RS01320	COG1696	Membrane protein involved in D-alanine export
I6L88_RS01325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L88_RS01330	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6L88_RS01335	COG1227	inorganic diphosphatase activity
I6L88_RS01345	COG2378	regulation of single-species biofilm formation
I6L88_RS01350	COG0693	protein deglycase activity
I6L88_RS01375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6L88_RS01380	COG2244	polysaccharide biosynthetic process
I6L88_RS01385	COG0626	cystathionine gamma-synthase activity
I6L88_RS01390	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6L88_RS01395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6L88_RS01400	COG0740	serine-type endopeptidase activity
I6L88_RS01410	COG4471	UPF0298 protein
I6L88_RS01420	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6L88_RS01440	COG0517	IMP dehydrogenase activity
I6L88_RS01445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6L88_RS01450	COG0470	DNA polymerase III
I6L88_RS01455	COG1774	PSP1 C-terminal conserved region
I6L88_RS01460	COG4467	Involved in initiation control of chromosome replication
I6L88_RS01470	COG0004	ammonium transporteR
I6L88_RS01475	COG0347	Belongs to the P(II) protein family
I6L88_RS01480	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6L88_RS01490	COG0454	-acetyltransferase
I6L88_RS01495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6L88_RS01500	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6L88_RS01505	COG1393	Belongs to the ArsC family
I6L88_RS01510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6L88_RS01515	COG0708	Exodeoxyribonuclease III
I6L88_RS01525	COG0640	Transcriptional regulator
I6L88_RS01565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L88_RS01565	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L88_RS01580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6L88_RS01605	COG1674	ftsk spoiiie
I6L88_RS01615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6L88_RS01620	COG0081	regulation of translation
I6L88_RS01625	COG0528	UMP kinase activity
I6L88_RS01630	COG0233	cytoplasmic translational termination
I6L88_RS01640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6L88_RS01645	COG4479	Belongs to the UPF0346 family
I6L88_RS01650	COG1702	phosphate starvation-inducible protein PhoH
I6L88_RS01655	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6L88_RS01660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6L88_RS01665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6L88_RS01680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6L88_RS01685	COG0237	dephospho-CoA kinase activity
I6L88_RS01695	COG2814	Major facilitator Superfamily
I6L88_RS01700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6L88_RS01710	COG0557	exoribonuclease II activity
I6L88_RS01715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6L88_RS01720	COG0346	lactoylglutathione lyase activity
I6L88_RS01725	COG0778	Nitroreductase
I6L88_RS01735	COG2723	6-phospho-beta-galactosidase activity
I6L88_RS01740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L88_RS01745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L88_RS01745	COG3711	transcriptional antiterminator
I6L88_RS01750	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6L88_RS01760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L88_RS01780	COG1609	Transcriptional regulator
I6L88_RS01795	COG0438	transferase activity, transferring glycosyl groups
I6L88_RS01810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6L88_RS01820	COG4716	Myosin-crossreactive antigen
I6L88_RS01825	COG1956	GAF domain-containing protein
I6L88_RS01830	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6L88_RS01880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6L88_RS01885	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L88_RS01890	COG3842	ATPase activity
I6L88_RS01895	COG3833	ABC-type maltose transport systems, permease component
I6L88_RS01900	COG1175	transmembrane transport
I6L88_RS01910	COG1609	Transcriptional regulator
I6L88_RS01915	COG1640	4-alpha-glucanotransferase
I6L88_RS01920	COG0058	SHG alpha-glucan phosphorylase activity
I6L88_RS01925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6L88_RS01930	COG0569	domain protein
I6L88_RS01950	COG4109	DRTGG domain
I6L88_RS01955	COG0024	Methionine aminopeptidase
I6L88_RS01960	COG1295	ribonuclease BN
I6L88_RS01980	COG1131	(ABC) transporter
I6L88_RS01990	COG4585	Histidine kinase
I6L88_RS01995	COG2197	response regulator
I6L88_RS02005	COG4708	membrane
I6L88_RS02010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6L88_RS02015	COG1597	lipid kinase activity
I6L88_RS02020	COG1523	belongs to the glycosyl hydrolase 13 family
I6L88_RS02025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6L88_RS02030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L88_RS02035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6L88_RS02040	COG0297	glycogen (starch) synthase activity
I6L88_RS02045	COG0058	SHG alpha-glucan phosphorylase activity
I6L88_RS02055	COG0356	it plays a direct role in the translocation of protons across the membrane
I6L88_RS02060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6L88_RS02065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6L88_RS02070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6L88_RS02075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6L88_RS02080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6L88_RS02085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6L88_RS02095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6L88_RS02110	COG0765	amino acid transport
I6L88_RS02115	COG0765	amino acid transport
I6L88_RS02120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L88_RS02125	COG1126	abc transporter atp-binding protein
I6L88_RS02130	COG0745	RESPONSE REGULATOR receiver
I6L88_RS02135	COG5002	protein histidine kinase activity
I6L88_RS02140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6L88_RS02145	COG0571	ribonuclease III activity
I6L88_RS02150	COG1196	nuclear chromosome segregation
I6L88_RS02155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6L88_RS02165	COG0072	phenylalanine-tRNA ligase activity
I6L88_RS02165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6L88_RS02170	COG1396	sequence-specific DNA binding
I6L88_RS02205	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6L88_RS02210	COG1074	ATP-dependent DNA helicase activity
I6L88_RS02215	COG1349	DNA-binding transcription factor activity
I6L88_RS02220	COG0698	ribose 5-phosphate isomerase
I6L88_RS02225	COG0698	ribose 5-phosphate isomerase
I6L88_RS02230	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L88_RS02235	COG3684	Belongs to the aldolase LacD family
I6L88_RS02250	COG3775	system Galactitol-specific IIC component
I6L88_RS02255	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6L88_RS02260	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L88_RS02260	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L88_RS02265	COG2723	6-phospho-beta-galactosidase activity
I6L88_RS02325	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6L88_RS02330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6L88_RS02340	COG1234	tRNA 3'-trailer cleavage
I6L88_RS02345	COG0300	oxidoreductase activity
I6L88_RS02350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6L88_RS02350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6L88_RS02355	COG2378	regulation of single-species biofilm formation
I6L88_RS02370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L88_RS02375	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I6L88_RS02385	COG2384	SAM-dependent methyltransferase
I6L88_RS02395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6L88_RS02400	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6L88_RS02415	COG1088	dTDP-glucose 4,6-dehydratase activity
I6L88_RS02420	COG1051	belongs to the nudix hydrolase family
I6L88_RS02425	COG0628	permease
I6L88_RS02435	COG0028	Belongs to the TPP enzyme family
I6L88_RS02440	COG3527	Alpha-acetolactate decarboxylase
I6L88_RS02445	COG1113	amino acid transport
I6L88_RS02450	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6L88_RS02465	COG3842	ATPase activity
I6L88_RS02485	COG4808	Protein conserved in bacteria
I6L88_RS02495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6L88_RS02510	COG1215	transferase activity, transferring glycosyl groups
I6L88_RS02520	COG0488	(ABC) transporter
I6L88_RS02525	COG3442	glutamine amidotransferase
I6L88_RS02530	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L88_RS02535	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6L88_RS02545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L88_RS02550	COG0542	response to heat
I6L88_RS02560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6L88_RS02565	COG0022	dehydrogenase e1 component
I6L88_RS02570	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L88_RS02575	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6L88_RS02585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6L88_RS02595	COG1051	belongs to the nudix hydrolase family
I6L88_RS02600	COG0647	UMP catabolic process
I6L88_RS02610	COG1136	(ABC) transporter
I6L88_RS02610	COG0577	efflux transmembrane transporter activity
I6L88_RS02620	COG3976	FMN-binding domain protein
I6L88_RS02620	COG1053	succinate dehydrogenase
I6L88_RS02635	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
I6L88_RS02640	COG1518	maintenance of DNA repeat elements
I6L88_RS02645	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
I6L88_RS02670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6L88_RS02685	COG0481	GTPase activity
I6L88_RS02710	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6L88_RS02720	COG0673	inositol 2-dehydrogenase activity
I6L88_RS02725	COG0572	uridine kinase
I6L88_RS02735	COG0473	3-isopropylmalate dehydrogenase activity
I6L88_RS02740	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6L88_RS02745	COG0066	3-isopropylmalate dehydratase activity
I6L88_RS02760	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I6L88_RS02760	COG0456	acetyltransferase
I6L88_RS02780	COG2801	Transposase and inactivated derivatives
I6L88_RS02785	COG2226	methyltransferase
I6L88_RS02790	COG1136	(ABC) transporter
I6L88_RS02805	COG1309	transcriptional regulator
I6L88_RS02830	COG1136	(ABC) transporter
I6L88_RS02920	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6L88_RS02930	COG2884	Cell division ATP-binding protein ftsE
I6L88_RS02935	COG2177	Part of the ABC transporter FtsEX involved in
I6L88_RS02975	COG1122	ATPase activity
I6L88_RS02985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6L88_RS02985	COG1199	ATP-dependent helicase activity
I6L88_RS02990	COG0436	Aminotransferase
I6L88_RS02995	COG0017	Asparaginyl-tRNA synthetase
I6L88_RS03000	COG0371	Dehydrogenase
I6L88_RS03005	COG0251	oxidation-reduction process
I6L88_RS03015	COG1660	Displays ATPase and GTPase activities
I6L88_RS03025	COG1481	regulation of sporulation
I6L88_RS03055	COG0254	rRNA binding
I6L88_RS03060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6L88_RS03065	COG0625	glutathione transferase activity
I6L88_RS03070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6L88_RS03075	COG0716	FMN binding
I6L88_RS03090	COG1605	Chorismate mutase
I6L88_RS03090	COG0077	Prephenate dehydratase
I6L88_RS03095	COG0038	chloride channel
I6L88_RS03100	COG0038	chloride channel
I6L88_RS03105	COG0335	large ribosomal subunit rRNA binding
I6L88_RS03115	COG2814	Major facilitator Superfamily
I6L88_RS03140	COG0772	Belongs to the SEDS family
I6L88_RS03155	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6L88_RS03160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6L88_RS03165	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6L88_RS03170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6L88_RS03175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6L88_RS03180	COG0560	Phosphoserine phosphatase
I6L88_RS03185	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L88_RS03195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6L88_RS03200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6L88_RS03205	COG0107	imidazoleglycerol-phosphate synthase activity
I6L88_RS03210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6L88_RS03275	COG0148	phosphopyruvate hydratase activity
I6L88_RS03285	COG1011	Hydrolase
I6L88_RS03295	COG0322	excinuclease ABC activity
I6L88_RS03305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6L88_RS03310	COG1573	uracil-dna glycosylase
I6L88_RS03330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6L88_RS03335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6L88_RS03340	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6L88_RS03370	COG0813	purine-nucleoside phosphorylase activity
I6L88_RS03385	COG0543	2 iron, 2 sulfur cluster binding
I6L88_RS03390	COG0167	dihydroorotate dehydrogenase activity
I6L88_RS03395	COG0284	orotidine-5'-phosphate decarboxylase activity
I6L88_RS03400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6L88_RS03405	COG1881	PFAM PEBP family protein
I6L88_RS03410	COG2315	Protein conserved in bacteria
I6L88_RS03420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L88_RS03425	COG0765	amino acid transport
I6L88_RS03430	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6L88_RS03440	COG0737	Belongs to the 5'-nucleotidase family
I6L88_RS03445	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6L88_RS03450	COG0187	DNA topoisomerase II activity
I6L88_RS03465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6L88_RS03485	COG0539	negative regulation of cytoplasmic translation
I6L88_RS03515	COG1131	(ABC) transporter
I6L88_RS03520	COG1725	Transcriptional regulator
I6L88_RS03530	COG0205	6-phosphofructokinase activity
I6L88_RS03535	COG0469	pyruvate kinase activity
I6L88_RS03540	COG2261	transglycosylase associated protein
I6L88_RS03550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6L88_RS03555	COG2213	PTS system mannitol-specific
I6L88_RS03560	COG3711	transcriptional antiterminator
I6L88_RS03565	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L88_RS03570	COG0246	Mannitol dehydrogenase
I6L88_RS03575	COG2824	Alkylphosphonate utilization operon protein PhnA
I6L88_RS03580	COG0765	amino acid transport
I6L88_RS03585	COG1126	abc transporter atp-binding protein
I6L88_RS03590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L88_RS03595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6L88_RS03600	COG1115	amino acid carrier protein
I6L88_RS03605	COG0210	DNA helicase
I6L88_RS03610	COG2873	o-acetylhomoserine
I6L88_RS03625	COG0785	Cytochrome C biogenesis protein
I6L88_RS03630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6L88_RS03655	COG2375	cellular response to nickel ion
I6L88_RS03655	COG1132	(ABC) transporter
I6L88_RS03660	COG1132	(ABC) transporter
I6L88_RS03720	COG0745	RESPONSE REGULATOR receiver
I6L88_RS03725	COG2205	protein histidine kinase activity
I6L88_RS03730	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6L88_RS03735	COG0196	riboflavin kinase activity
I6L88_RS03740	COG1393	Belongs to the ArsC family
I6L88_RS03745	COG4476	Belongs to the UPF0223 family
I6L88_RS03750	COG0483	inositol monophosphate 1-phosphatase activity
I6L88_RS03755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L88_RS03755	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I6L88_RS03765	COG0573	inorganic phosphate transmembrane transporter activity
I6L88_RS03770	COG0581	inorganic phosphate transmembrane transporter activity
I6L88_RS03775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L88_RS03780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6L88_RS03785	COG0704	Plays a role in the regulation of phosphate uptake
I6L88_RS03800	COG0745	RESPONSE REGULATOR receiver
I6L88_RS03805	COG5002	protein histidine kinase activity
I6L88_RS03810	COG0268	Binds directly to 16S ribosomal RNA
I6L88_RS03815	COG1072	(Pantothenic acid kinase))
I6L88_RS03820	COG2813	Specifically methylates the guanine in position
I6L88_RS03825	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6L88_RS03830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6L88_RS03835	COG0295	cytidine deaminase activity
I6L88_RS03840	COG1744	ABC transporter substrate-binding protein PnrA-like
I6L88_RS03845	COG3845	ABC transporter
I6L88_RS03850	COG4603	Belongs to the binding-protein-dependent transport system permease family
I6L88_RS03855	COG1079	Belongs to the binding-protein-dependent transport system permease family
I6L88_RS03870	COG0039	L-malate dehydrogenase activity
I6L88_RS03880	COG3764	Sortase (surface protein transpeptidase)
I6L88_RS03885	COG0346	lactoylglutathione lyase activity
I6L88_RS03900	COG0561	phosphatase activity
I6L88_RS03915	COG0406	alpha-ribazole phosphatase activity
I6L88_RS03925	COG2723	6-phospho-beta-galactosidase activity
I6L88_RS03930	COG0628	permease
I6L88_RS03935	COG1063	alcohol dehydrogenase
I6L88_RS03950	COG1174	glycine betaine transport
I6L88_RS03955	COG1136	(ABC) transporter
I6L88_RS03960	COG0577	efflux transmembrane transporter activity
I6L88_RS03970	COG3976	FMN-binding domain protein
I6L88_RS03970	COG1053	succinate dehydrogenase
I6L88_RS03970	COG0431	NADPH-dependent FMN reductase
I6L88_RS03985	COG1942	4-Oxalocrotonate Tautomerase
I6L88_RS03990	COG1435	thymidine kinase activity
I6L88_RS03995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6L88_RS04000	COG2890	protein-(glutamine-N5) methyltransferase activity
I6L88_RS04005	COG0009	L-threonylcarbamoyladenylate synthase
I6L88_RS04010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6L88_RS04025	COG1132	(ABC) transporter
I6L88_RS04030	COG1132	(ABC) transporter
I6L88_RS04035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6L88_RS04040	COG4684	Psort location CytoplasmicMembrane, score
I6L88_RS04045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6L88_RS04055	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6L88_RS04060	COG1247	-acetyltransferase
I6L88_RS04080	COG1131	(ABC) transporter
I6L88_RS04090	COG0519	Catalyzes the synthesis of GMP from XMP
I6L88_RS04095	COG2188	Transcriptional regulator
I6L88_RS04105	COG4175	Glycine betaine
I6L88_RS04105	COG3448	diguanylate cyclase activity
I6L88_RS04115	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6L88_RS04120	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6L88_RS04145	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6L88_RS04150	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6L88_RS04160	COG1104	cysteine desulfurase activity
I6L88_RS04165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L88_RS04170	COG4116	CYTH
I6L88_RS04180	COG2357	RelA SpoT domain protein
I6L88_RS04185	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6L88_RS04190	COG0564	pseudouridine synthase activity
I6L88_RS04195	COG0280	phosphate acetyltransferase
I6L88_RS04205	COG1131	(ABC) transporter
I6L88_RS04210	COG4221	oxidoreductase activity
I6L88_RS04215	COG1442	glycosyl transferase family 8
I6L88_RS04220	COG0745	RESPONSE REGULATOR receiver
I6L88_RS04225	COG5002	protein histidine kinase activity
I6L88_RS04235	COG1131	(ABC) transporter
I6L88_RS04240	COG4974	Belongs to the 'phage' integrase family
I6L88_RS04270	COG3052	prosthetic group binding
I6L88_RS04275	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
I6L88_RS04280	COG0511	ligase activity, forming carbon-carbon bonds
I6L88_RS04290	COG2851	Citrate transporter
I6L88_RS04300	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6L88_RS04305	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6L88_RS04310	COG0642	Histidine kinase
I6L88_RS04315	COG0745	RESPONSE REGULATOR receiver
I6L88_RS04325	COG1136	(ABC) transporter
I6L88_RS04330	COG0366	Alpha amylase catalytic
I6L88_RS04330	COG5263	repeat protein
I6L88_RS04335	COG0366	Alpha amylase catalytic
I6L88_RS04335	COG5263	repeat protein
I6L88_RS04340	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6L88_RS04345	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6L88_RS04350	COG0758	DNA mediated transformation
I6L88_RS04360	COG4607	ABC-type enterochelin transport system periplasmic component
I6L88_RS04365	COG4604	ABC transporter, ATP-binding protein
I6L88_RS04370	COG4605	iron ion homeostasis
I6L88_RS04375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6L88_RS04380	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6L88_RS04385	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6L88_RS04400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6L88_RS04405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6L88_RS04415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6L88_RS04420	COG4932	domain protein
I6L88_RS04450	COG1263	PTS System
I6L88_RS04450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L88_RS04450	COG2190	(PTS) system
I6L88_RS04455	COG3711	transcriptional antiterminator
I6L88_RS04460	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6L88_RS04465	COG1177	transmembrane transport
I6L88_RS04470	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6L88_RS04475	COG3842	ATPase activity
I6L88_RS04480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6L88_RS04500	COG0302	gtp cyclohydrolase
I6L88_RS04505	COG0285	dihydrofolate synthase activity
I6L88_RS04510	COG0083	homoserine kinase activity
I6L88_RS04520	COG0726	polysaccharide deacetylase
I6L88_RS04525	COG1960	acyl-CoA dehydrogenase activity
I6L88_RS04535	COG0222	ribosome binding
I6L88_RS04540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6L88_RS04560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L88_RS04565	COG2040	homocysteine
I6L88_RS04575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6L88_RS04580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6L88_RS04590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6L88_RS04595	COG3201	nicotinamide mononucleotide transporter
I6L88_RS04600	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6L88_RS04605	COG3425	synthase
I6L88_RS04620	COG1272	protein, Hemolysin III
I6L88_RS04625	COG1304	FMN binding
I6L88_RS04640	COG1126	abc transporter atp-binding protein
I6L88_RS04645	COG0765	amino acid transport
I6L88_RS04650	COG0765	amino acid transport
I6L88_RS04655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L88_RS04665	COG0583	DNA-binding transcription factor activity
I6L88_RS04670	COG3759	membrane
I6L88_RS04680	COG0745	RESPONSE REGULATOR receiver
I6L88_RS04685	COG2357	RelA SpoT domain protein
I6L88_RS04695	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6L88_RS04700	COG1132	(ABC) transporter
I6L88_RS04715	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6L88_RS04725	COG0602	queuosine metabolic process
I6L88_RS04730	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6L88_RS04740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6L88_RS04750	COG5263	repeat protein
I6L88_RS04750	COG0366	Alpha amylase catalytic
I6L88_RS04760	COG1132	(ABC) transporter
I6L88_RS04770	COG0488	(ABC) transporter
I6L88_RS04775	COG0617	tRNA 3'-terminal CCA addition
I6L88_RS04780	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6L88_RS04785	COG1307	EDD domain protein, DegV family
I6L88_RS04800	COG1131	(ABC) transporter
I6L88_RS04820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L88_RS04825	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6L88_RS04830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6L88_RS04835	COG1609	Transcriptional regulator
I6L88_RS04840	COG0366	Alpha amylase catalytic
I6L88_RS04845	COG3842	ATPase activity
I6L88_RS04850	COG0366	Alpha amylase catalytic
I6L88_RS04855	COG0395	ABC-type sugar transport system, permease component
I6L88_RS04860	COG1175	transmembrane transport
I6L88_RS04865	COG1653	transport
I6L88_RS04870	COG3345	alpha-galactosidase
I6L88_RS04875	COG2207	Transcriptional regulator
I6L88_RS04890	COG0646	methionine synthase
I6L88_RS04890	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6L88_RS04895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6L88_RS04900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L88_RS04900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L88_RS04900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L88_RS04905	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L88_RS04910	COG1349	DNA-binding transcription factor activity
I6L88_RS04915	COG0492	ferredoxin-NADP+ reductase activity
I6L88_RS04920	COG0336	Belongs to the RNA methyltransferase TrmD family
I6L88_RS04925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6L88_RS04930	COG1837	Belongs to the UPF0109 family
I6L88_RS04935	COG0228	four-way junction DNA binding
I6L88_RS04940	COG0577	efflux transmembrane transporter activity
I6L88_RS04945	COG1136	(ABC) transporter
I6L88_RS04955	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6L88_RS04960	COG0505	Belongs to the CarA family
I6L88_RS04965	COG0540	Belongs to the ATCase OTCase family
I6L88_RS04975	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6L88_RS04985	COG0564	pseudouridine synthase activity
I6L88_RS04990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6L88_RS04995	COG0583	DNA-binding transcription factor activity
I6L88_RS05000	COG2816	NAD+ diphosphatase activity
I6L88_RS05010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6L88_RS05020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6L88_RS05040	COG0301	tRNA thio-modification
I6L88_RS05045	COG1104	cysteine desulfurase activity
I6L88_RS05055	COG0285	dihydrofolate synthase activity
I6L88_RS05060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6L88_RS05065	COG0656	L-ascorbic acid biosynthetic process
I6L88_RS05070	COG3942	CHAP domain
I6L88_RS05085	COG0463	Glycosyl transferase, family 2
I6L88_RS05095	COG1368	sulfuric ester hydrolase activity
I6L88_RS05130	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6L88_RS05135	COG2151	metal-sulfur cluster biosynthetic enzyme
I6L88_RS05140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6L88_RS05145	COG0358	DNA primase activity
I6L88_RS05155	COG1970	mechanosensitive ion channel activity
I6L88_RS05165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L88_RS05175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6L88_RS05180	COG1051	belongs to the nudix hydrolase family
I6L88_RS05200	COG0556	nucleotide-excision repair
I6L88_RS05215	COG1126	abc transporter atp-binding protein
I6L88_RS05220	COG0488	(ABC) transporter
I6L88_RS05230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6L88_RS05285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6L88_RS05295	COG0077	Prephenate dehydratase
I6L88_RS05300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6L88_RS05305	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6L88_RS05310	COG3679	Belongs to the UPF0342 family
I6L88_RS05315	COG0287	Prephenate dehydrogenase
I6L88_RS05320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6L88_RS05325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6L88_RS05330	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6L88_RS05335	COG0710	3-dehydroquinate dehydratase activity
I6L88_RS05340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6L88_RS05345	COG1368	sulfuric ester hydrolase activity
I6L88_RS05365	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6L88_RS05370	COG5263	repeat protein
I6L88_RS05370	COG0366	Alpha amylase catalytic
I6L88_RS05375	COG1914	H( )-stimulated, divalent metal cation uptake system
I6L88_RS05380	COG4443	Transcriptional Coactivator p15 (PC4)
I6L88_RS05395	COG0450	alkyl hydroperoxide reductase
I6L88_RS05400	COG0826	peptidase U32
I6L88_RS05425	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6L88_RS05430	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6L88_RS05440	COG3091	SprT-like family
I6L88_RS05445	COG2183	response to ionizing radiation
I6L88_RS05450	COG0701	Predicted permease
I6L88_RS05455	COG3689	TIGRFAM TIGR03943 family protein
I6L88_RS05460	COG0477	Major facilitator Superfamily
I6L88_RS05465	COG0552	protein localization to endoplasmic reticulum
I6L88_RS05470	COG0561	phosphatase activity
I6L88_RS05475	COG0561	phosphatase activity
I6L88_RS05520	COG1131	(ABC) transporter
I6L88_RS05530	COG0604	alcohol dehydrogenase
I6L88_RS05545	COG0584	glycerophosphoryl diester phosphodiesterase
I6L88_RS05565	COG1078	dGTPase activity
I6L88_RS05575	COG2348	transferase activity, transferring amino-acyl groups
I6L88_RS05585	COG0149	triose-phosphate isomerase activity
I6L88_RS05590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6L88_RS05595	COG0772	Belongs to the SEDS family
I6L88_RS05600	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I6L88_RS05620	COG3859	Proton-coupled thiamine transporter YuaJ
I6L88_RS05635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6L88_RS05645	COG0588	phosphoglycerate mutase activity
I6L88_RS05650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6L88_RS05655	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6L88_RS05660	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6L88_RS05665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6L88_RS05685	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6L88_RS05740	COG0656	L-ascorbic acid biosynthetic process
I6L88_RS05745	COG0656	L-ascorbic acid biosynthetic process
I6L88_RS05750	COG0789	Transcriptional regulator
I6L88_RS05755	COG1012	belongs to the aldehyde dehydrogenase family
I6L88_RS05760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6L88_RS05765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L88_RS05775	COG0538	isocitrate dehydrogenase activity
I6L88_RS05785	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6L88_RS05790	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6L88_RS05795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6L88_RS05805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6L88_RS05810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6L88_RS05815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6L88_RS05820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6L88_RS05860	COG1131	(ABC) transporter
I6L88_RS05880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6L88_RS05890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6L88_RS05895	COG4122	O-methyltransferase activity
I6L88_RS05900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6L88_RS05900	COG0131	Imidazoleglycerol-phosphate dehydratase
I6L88_RS05930	COG3321	synthase
I6L88_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
I6L88_RS05930	COG0604	alcohol dehydrogenase
I6L88_RS05935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6L88_RS05945	COG1187	pseudouridine synthase activity
I6L88_RS05955	COG0363	glucosamine-6-phosphate deaminase activity
I6L88_RS05965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6L88_RS05990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6L88_RS06005	COG2333	competence protein COMEC
I6L88_RS06005	COG0658	competence protein
I6L88_RS06010	COG1596	polysaccharide export
I6L88_RS06010	COG1555	photosystem II stabilization
I6L88_RS06015	COG0204	Acyl-transferase
I6L88_RS06020	COG0726	polysaccharide deacetylase
I6L88_RS06030	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6L88_RS06055	COG0513	Belongs to the DEAD box helicase family
I6L88_RS06060	COG3064	Membrane
I6L88_RS06060	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6L88_RS06070	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6L88_RS06090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6L88_RS06095	COG0385	Bile acid
I6L88_RS06105	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L88_RS06110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6L88_RS06115	COG0768	penicillin binding
I6L88_RS06120	COG0588	phosphoglycerate mutase activity
I6L88_RS06135	COG0735	belongs to the Fur family
I6L88_RS06155	COG0776	regulation of translation
I6L88_RS06165	COG2755	lipolytic protein G-D-S-L family
I6L88_RS06170	COG1307	EDD domain protein, DegV family
I6L88_RS06175	COG0497	DNA recombination
I6L88_RS06180	COG1438	arginine binding
I6L88_RS06185	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I6L88_RS06195	COG1722	exodeoxyribonuclease VII activity
I6L88_RS06200	COG1570	exodeoxyribonuclease VII activity
I6L88_RS06205	COG3275	phosphorelay sensor kinase activity
I6L88_RS06210	COG3279	Response regulator of the LytR AlgR family
I6L88_RS06215	COG1380	Effector of murein hydrolase LrgA
I6L88_RS06220	COG1346	cytolysis
I6L88_RS06225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6L88_RS06230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6L88_RS06250	COG1126	abc transporter atp-binding protein
I6L88_RS06255	COG0765	amino acid transport
I6L88_RS06260	COG4703	Protein of unknown function (DUF1797)
I6L88_RS06265	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L88_RS06270	COG0542	response to heat
I6L88_RS06285	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6L88_RS06290	COG3599	regulation of cell shape
I6L88_RS06295	COG2302	S4 RNA-binding domain
I6L88_RS06305	COG1799	cell septum assembly
I6L88_RS06310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6L88_RS06320	COG0849	cell division
I6L88_RS06330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6L88_RS06335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6L88_RS06345	COG1217	gtp-binding protein TYPA
I6L88_RS06350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6L88_RS06355	COG1940	carbohydrate kinase activity
I6L88_RS06365	COG0783	Belongs to the Dps family
I6L88_RS06375	COG0159	tryptophan synthase activity
I6L88_RS06380	COG0133	tryptophan synthase activity
I6L88_RS06385	COG0135	phosphoribosylanthranilate isomerase activity
I6L88_RS06390	COG0134	indole-3-glycerol-phosphate synthase activity
I6L88_RS06395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6L88_RS06400	COG0512	Glutamine amidotransferase of anthranilate synthase
I6L88_RS06405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6L88_RS06425	COG3804	dihydrodipicolinate reductase
I6L88_RS06435	COG1132	(ABC) transporter
I6L88_RS06440	COG1132	(ABC) transporter
I6L88_RS06450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6L88_RS06455	COG4470	Protein conserved in bacteria
I6L88_RS06460	COG0737	Belongs to the 5'-nucleotidase family
I6L88_RS06465	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6L88_RS06470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6L88_RS06475	COG0742	ribosomal rna small subunit methyltransferase
I6L88_RS06480	COG4716	Myosin-crossreactive antigen
I6L88_RS06535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L88_RS06545	COG0561	phosphatase activity
I6L88_RS06550	COG1349	DNA-binding transcription factor activity
I6L88_RS06595	COG1040	competence protein
I6L88_RS06600	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6L88_RS06605	COG1739	Uncharacterized protein family UPF0029
I6L88_RS06625	COG1882	Formate acetyltransferase
I6L88_RS06630	COG1349	DNA-binding transcription factor activity
I6L88_RS06635	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6L88_RS06640	COG1098	S1 RNA binding domain
I6L88_RS06650	COG2197	response regulator
I6L88_RS06655	COG4585	Histidine kinase
I6L88_RS06675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6L88_RS06675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6L88_RS06680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6L88_RS06685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6L88_RS06690	COG1758	RNA polymerase activity
I6L88_RS06695	COG0194	GDP metabolic process
I6L88_RS06700	COG1418	mRNA catabolic process
I6L88_RS06700	COG4372	Transposase
I6L88_RS06705	COG1854	S-ribosylhomocysteine lyase activity
I6L88_RS06715	COG0116	Belongs to the methyltransferase superfamily
I6L88_RS06725	COG3599	regulation of cell shape
I6L88_RS06730	COG4474	Belongs to the UPF0398 family
I6L88_RS06735	COG3331	DNA recombination
I6L88_RS06740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L88_RS06745	COG3579	cysteine-type endopeptidase activity
I6L88_RS06750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6L88_RS06755	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6L88_RS06760	COG0492	ferredoxin-NADP+ reductase activity
I6L88_RS06770	COG1126	abc transporter atp-binding protein
I6L88_RS06785	COG0513	Belongs to the DEAD box helicase family
I6L88_RS06795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L88_RS06800	COG0768	penicillin binding
I6L88_RS06805	COG4839	cell division protein FtsL
I6L88_RS06810	COG0275	rRNA processing
I6L88_RS06815	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I6L88_RS06820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I6L88_RS06830	COG4224	UPF0291 protein
I6L88_RS06835	COG0751	glycine-tRNA ligase activity
I6L88_RS06840	COG0752	glycyl-tRNA synthetase alpha subunit
I6L88_RS06845	COG1673	EVE domain
I6L88_RS06865	COG1924	4 iron, 4 sulfur cluster binding
I6L88_RS06890	COG1131	(ABC) transporter
I6L88_RS06900	COG0561	phosphatase activity
I6L88_RS06910	COG2217	Heavy metal translocating P-type atpase
I6L88_RS06925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6L88_RS06930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6L88_RS06940	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6L88_RS06945	COG0195	Participates in both transcription termination and antitermination
I6L88_RS06950	COG0779	Required for maturation of 30S ribosomal subunits
I6L88_RS06960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6L88_RS06970	COG4473	ABC transporter
I6L88_RS06975	COG1131	(ABC) transporter
I6L88_RS06980	COG0537	adenosine 5'-monophosphoramidase activity
I6L88_RS06990	COG1316	TRANSCRIPTIONal
I6L88_RS06995	COG0802	atpase or kinase
I6L88_RS07000	COG2252	PERMEase
I6L88_RS07010	COG0561	phosphatase activity
I6L88_RS07025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6L88_RS07030	COG1882	Formate acetyltransferase
I6L88_RS07040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6L88_RS07055	COG2936	dipeptidyl-peptidase activity
I6L88_RS07060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6L88_RS07065	COG1733	regulation of RNA biosynthetic process
I6L88_RS07070	COG0778	Nitroreductase
I6L88_RS07080	COG2081	HI0933 family
I6L88_RS07100	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6L88_RS07105	COG0456	acetyltransferase
I6L88_RS07110	COG1214	PFAM Peptidase M22, glycoprotease
I6L88_RS07120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6L88_RS07125	COG0667	Aldo Keto reductase
I6L88_RS07150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6L88_RS07165	COG2226	methyltransferase
I6L88_RS07185	COG5503	Protein of unknown function (DUF1447)
I6L88_RS07195	COG3942	CHAP domain
I6L88_RS07200	COG0493	'glutamate synthase
I6L88_RS07205	COG0067	glutamate synthase
I6L88_RS07205	COG0069	glutamate synthase activity
I6L88_RS07205	COG0070	glutamate synthase
I6L88_RS07210	COG0174	glutamine synthetase
I6L88_RS07215	COG0789	Transcriptional regulator
I6L88_RS07225	COG0126	phosphoglycerate kinase activity
I6L88_RS07235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6L88_RS07240	COG0049	tRNA binding
I6L88_RS07245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6L88_RS07250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6L88_RS07275	COG1162	GTPase activity
I6L88_RS07295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6L88_RS07330	COG0084	hydrolase, TatD family'
I6L88_RS07335	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6L88_RS07350	COG0706	membrane insertase activity
I6L88_RS07355	COG0594	ribonuclease P activity
I6L88_RS07360	COG0165	Argininosuccinate lyase
I6L88_RS07365	COG0137	argininosuccinate synthase activity
I6L88_RS07380	COG1827	regulation of RNA biosynthetic process
I6L88_RS07385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6L88_RS07410	COG0756	dUTP diphosphatase activity
I6L88_RS07415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6L88_RS07420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6L88_RS07425	COG0457	Tetratricopeptide repeat
I6L88_RS07425	COG0705	Rhomboid family
I6L88_RS07430	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6L88_RS07435	COG1473	amidohydrolase
I6L88_RS07440	COG2171	N-acyltransferase activity
I6L88_RS07455	COG3732	PTS system glucitol sorbitol-specific
I6L88_RS07460	COG3730	PTS system glucitol sorbitol-specific
I6L88_RS07470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L88_RS07470	COG3711	transcriptional antiterminator
I6L88_RS07480	COG0166	Belongs to the GPI family
I6L88_RS07500	COG1234	tRNA 3'-trailer cleavage
I6L88_RS07515	COG0343	queuine tRNA-ribosyltransferase activity
I6L88_RS07525	COG1832	CoA-binding protein
I6L88_RS07530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L88_RS07530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6L88_RS07560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6L88_RS07580	COG2274	protein secretion by the type I secretion system
I6L88_RS07625	COG3623	hexulose-6-phosphate isomerase
I6L88_RS07635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L88_RS07650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6L88_RS07655	COG2918	glutathione biosynthetic process
I6L88_RS07655	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6L88_RS07665	COG2957	Belongs to the agmatine deiminase family
I6L88_RS07670	COG0531	amino acid
I6L88_RS07675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6L88_RS07690	COG4608	Belongs to the ABC transporter superfamily
I6L88_RS07695	COG0444	Belongs to the ABC transporter superfamily
I6L88_RS07700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6L88_RS07705	COG0601	transmembrane transport
I6L88_RS07710	COG4166	transmembrane transport
I6L88_RS07725	COG0719	Fe-S assembly protein
I6L88_RS07735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6L88_RS07740	COG0719	Fe-S assembly protein
I6L88_RS07750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6L88_RS07755	COG4862	establishment of competence for transformation
I6L88_RS07760	COG1968	undecaprenyl-diphosphatase activity
I6L88_RS07770	COG0765	amino acid transport
I6L88_RS07775	COG1126	abc transporter atp-binding protein
I6L88_RS07785	COG1131	(ABC) transporter
I6L88_RS07795	COG1309	transcriptional regulator
I6L88_RS07805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6L88_RS07810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6L88_RS07815	COG0440	acetolactate synthase activity
I6L88_RS07820	COG0028	Belongs to the TPP enzyme family
I6L88_RS07825	COG1461	Dihydroxyacetone kinase
I6L88_RS07860	COG0582	viral genome integration into host DNA
I6L88_RS07950	COG0203	ribosomal protein L17
I6L88_RS07955	COG0202	RNA polymerase activity
I6L88_RS07960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6L88_RS07965	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6L88_RS07975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6L88_RS07980	COG0563	adenylate kinase activity
I6L88_RS07985	COG0201	protein transport
I6L88_RS07990	COG0200	Binds to the 23S rRNA
I6L88_RS07995	COG1841	ribosomal large subunit assembly
I6L88_RS08000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6L88_RS08010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6L88_RS08015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6L88_RS08020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6L88_RS08025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6L88_RS08030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6L88_RS08035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6L88_RS08040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6L88_RS08045	COG0255	Belongs to the universal ribosomal protein uL29 family
I6L88_RS08050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6L88_RS08055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6L88_RS08060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6L88_RS08070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6L88_RS08075	COG0089	rRNA binding
I6L88_RS08085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6L88_RS08090	COG0051	transcription antitermination factor activity, RNA binding
I6L88_RS08100	COG1621	beta-fructofuranosidase activity
I6L88_RS08105	COG0542	response to heat
I6L88_RS08110	COG4463	regulation of RNA biosynthetic process
I6L88_RS08115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6L88_RS08120	COG0052	Belongs to the universal ribosomal protein uS2 family
I6L88_RS08135	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6L88_RS08140	COG3590	peptidase
I6L88_RS08150	COG0366	Alpha amylase catalytic
I6L88_RS08155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L88_RS08155	COG1263	PTS System
I6L88_RS08160	COG2188	Transcriptional regulator
I6L88_RS08170	COG5297	Belongs to the glycosyl hydrolase family 6
I6L88_RS08175	COG1490	D-aminoacyl-tRNA deacylase activity
I6L88_RS08190	COG2190	(PTS) system
I6L88_RS08190	COG1263	PTS System
I6L88_RS08190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6L88_RS08200	COG1609	Transcriptional regulator
I6L88_RS08205	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6L88_RS08210	COG2264	protein methyltransferase activity
I6L88_RS08230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6L88_RS08245	COG2217	Heavy metal translocating P-type atpase
I6L88_RS08265	COG0577	efflux transmembrane transporter activity
I6L88_RS08265	COG1136	(ABC) transporter
I6L88_RS08275	COG1396	sequence-specific DNA binding
I6L88_RS08290	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6L88_RS08295	COG0577	efflux transmembrane transporter activity
I6L88_RS08295	COG1136	(ABC) transporter
I6L88_RS08310	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6L88_RS08335	COG2855	membrane
I6L88_RS08340	COG0583	DNA-binding transcription factor activity
I6L88_RS08350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6L88_RS08360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6L88_RS08370	COG0463	Glycosyl transferase, family 2
I6L88_RS08375	COG0428	transporter
I6L88_RS08380	COG3022	response to hydroperoxide
I6L88_RS08410	COG3906	Belongs to the UPF0473 family
I6L88_RS08415	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6L88_RS08420	COG4472	Bacterial protein of unknown function (DUF965)
I6L88_RS08445	COG1393	Belongs to the ArsC family
I6L88_RS08450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6L88_RS08455	COG1546	Belongs to the CinA family
I6L88_RS08455	COG1058	Belongs to the CinA family
I6L88_RS08460	COG0519	Catalyzes the synthesis of GMP from XMP
I6L88_RS08465	COG0632	four-way junction helicase activity
I6L88_RS08470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6L88_RS08480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6L88_RS08490	COG1438	arginine binding
I6L88_RS08510	COG0018	arginyl-trna synthetase
I6L88_RS08515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6L88_RS08520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6L88_RS08525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6L88_RS08530	COG0124	histidyl-tRNA synthetase
I6L88_RS08535	COG0531	amino acid
I6L88_RS08540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6L88_RS08545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6L88_RS08565	COG2814	Major facilitator Superfamily
I6L88_RS08590	COG0789	Transcriptional regulator
I6L88_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
I6L88_RS08620	COG2094	Belongs to the DNA glycosylase MPG family
I6L88_RS08635	COG1733	regulation of RNA biosynthetic process
I6L88_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
I6L88_RS08650	COG0129	dihydroxy-acid dehydratase activity
I6L88_RS08655	COG2151	metal-sulfur cluster biosynthetic enzyme
I6L88_RS08675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6L88_RS08685	COG0305	Participates in initiation and elongation during chromosome replication
I6L88_RS08690	COG0359	binds to the 23S rRNA
I6L88_RS08700	COG0445	tRNA wobble uridine modification
I6L88_RS08710	COG0482	sulfurtransferase activity
I6L88_RS08715	COG0741	lytic transglycosylase activity
I6L88_RS08725	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6L88_RS08730	COG1122	ATPase activity
I6L88_RS08735	COG1122	ATPase activity
I6L88_RS08740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6L88_RS08750	COG0612	Peptidase, M16
I6L88_RS08765	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6L88_RS08770	COG0517	IMP dehydrogenase activity
I6L88_RS08770	COG0516	GMP reductase activity
I6L88_RS08775	COG0180	Tryptophanyl-tRNA synthetase
I6L88_RS08780	COG0488	(ABC) transporter
I6L88_RS08810	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6L88_RS08815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6L88_RS08820	COG1475	DNA binding
I6L88_RS08825	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6L88_RS08830	COG0592	DNA-directed DNA polymerase activity
I6L88_RS08840	COG0012	GTP binding
I6L88_RS08845	COG0193	aminoacyl-tRNA hydrolase activity
I6L88_RS08850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6L88_RS08855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6L88_RS08875	COG0037	tRNA processing
I6L88_RS08880	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6L88_RS08885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6L88_RS08890	COG0531	amino acid
I6L88_RS09000	COG1792	Involved in formation and maintenance of cell shape
I6L88_RS09010	COG3942	CHAP domain
I6L88_RS09015	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6L88_RS09020	COG0436	Aminotransferase
I6L88_RS09025	COG1381	Involved in DNA repair and RecF pathway recombination
I6L88_RS09030	COG0416	fatty acid biosynthetic process
I6L88_RS09035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6L88_RS09040	COG2274	protein secretion by the type I secretion system
I6L88_RS09045	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6L88_RS09050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6L88_RS09060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6L88_RS09065	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6L88_RS09070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6L88_RS09080	COG0138	bifunctional purine biosynthesis protein purh
I6L88_RS09095	COG0653	protein targeting
I6L88_RS09115	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6L88_RS09130	COG1794	racemase activity, acting on amino acids and derivatives
I6L88_RS09155	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6L88_RS09195	COG2255	four-way junction helicase activity
I6L88_RS09200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6L88_RS09220	COG0534	Mate efflux family protein
I6L88_RS09225	COG3830	Belongs to the UPF0237 family
I6L88_RS09230	COG2848	UPF0210 protein
I6L88_RS09245	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6L88_RS09250	COG1621	beta-fructofuranosidase activity
I6L88_RS09250	COG3583	domain protein
I6L88_RS09250	COG5492	domain, Protein
I6L88_RS09260	COG1420	regulation of RNA biosynthetic process
I6L88_RS09265	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6L88_RS09270	COG0443	Heat shock 70 kDa protein
I6L88_RS09275	COG0484	heat shock protein binding
I6L88_RS09280	COG0101	tRNA pseudouridine synthase activity
I6L88_RS09285	COG0351	phosphomethylpyrimidine kinase
I6L88_RS09290	COG4720	Psort location CytoplasmicMembrane, score
I6L88_RS09295	COG4475	Protein of unknown function (DUF436)
I6L88_RS09300	COG0668	transmembrane transport
I6L88_RS09310	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6L88_RS09315	COG3343	RNA polymerase activity
I6L88_RS09320	COG0504	CTP synthase activity
I6L88_RS09335	COG0191	fructose-bisphosphate aldolase activity
I6L88_RS09345	COG3715	PTS system
I6L88_RS09395	COG1396	sequence-specific DNA binding
I6L88_RS09405	COG1105	Belongs to the carbohydrate kinase PfkB family
I6L88_RS09410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L88_RS09410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L88_RS09410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L88_RS09415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L88_RS09415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6L88_RS09415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6L88_RS09420	COG3684	Belongs to the aldolase LacD family
I6L88_RS09435	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I6L88_RS09440	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6L88_RS09445	COG0534	Mate efflux family protein
I6L88_RS09450	COG2176	DNA-directed DNA polymerase activity
I6L88_RS09455	COG1846	Transcriptional regulator
I6L88_RS09460	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6L88_RS09465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6L88_RS09470	COG0022	dehydrogenase e1 component
I6L88_RS09470	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6L88_RS09485	COG0095	Lipoate-protein ligase
I6L88_RS09490	COG1473	amidohydrolase
I6L88_RS09495	COG0477	Major facilitator Superfamily
I6L88_RS09500	COG1309	transcriptional regulator
I6L88_RS09505	COG0583	DNA-binding transcription factor activity
I6L88_RS09515	COG0281	malic enzyme
I6L88_RS09520	COG0679	Auxin Efflux Carrier
I6L88_RS09525	COG2140	Oxalate decarboxylase
I6L88_RS09540	COG0242	peptide deformylase activity
I6L88_RS09545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6L88_RS09555	COG1012	belongs to the aldehyde dehydrogenase family
I6L88_RS09555	COG1454	alcohol dehydrogenase
I6L88_RS09585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6L88_RS09590	COG1185	polyribonucleotide nucleotidyltransferase activity
I6L88_RS09600	COG1045	serine acetyltransferase
I6L88_RS09605	COG0215	cysteine-tRNA ligase activity
I6L88_RS09610	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6L88_RS09615	COG5504	Zn-dependent protease
I6L88_RS09635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6L88_RS09655	COG1476	TRANSCRIPTIONal
I6L88_RS09660	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6L88_RS09665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6L88_RS09670	COG4974	Belongs to the 'phage' integrase family
I6L88_RS09690	COG3942	CHAP domain
I6L88_RS09690	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6L88_RS09705	COG0433	COG0433 Predicted ATPase
I6L88_RS09745	COG4115	mRNA cleavage
I6L88_RS09755	COG1674	ftsk spoiiie
I6L88_RS09790	COG1396	sequence-specific DNA binding
I6L88_RS09855	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6L88_RS09865	COG1053	succinate dehydrogenase
I6L88_RS09865	COG0431	NADPH-dependent FMN reductase
I6L88_RS09865	COG3976	FMN-binding domain protein
I6L88_RS09870	COG0431	NADPH-dependent FMN reductase
I6L88_RS09870	COG1053	succinate dehydrogenase
I6L88_RS09870	COG3976	FMN-binding domain protein
I6L88_RS09875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6L88_RS09890	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6L88_RS09900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6L88_RS09905	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6L88_RS09940	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6L88_RS09950	COG1121	(ABC) transporter
I6L88_RS09955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6L88_RS09960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6L88_RS09965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6L88_RS10025	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6L88_RS10070	COG1733	regulation of RNA biosynthetic process