locus-tag	class	description
SMUGS5_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMUGS5_RS00010	COG0592	DNA-directed DNA polymerase activity
SMUGS5_RS00020	COG0012	GTP binding
SMUGS5_RS00025	COG0193	aminoacyl-tRNA hydrolase activity
SMUGS5_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMUGS5_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMUGS5_RS00055	COG0037	tRNA processing
SMUGS5_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SMUGS5_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMUGS5_RS00070	COG0531	amino acid
SMUGS5_RS00190	COG3942	CHAP domain
SMUGS5_RS00195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMUGS5_RS00200	COG0436	Aminotransferase
SMUGS5_RS00205	COG1381	Involved in DNA repair and RecF pathway recombination
SMUGS5_RS00210	COG0416	fatty acid biosynthetic process
SMUGS5_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMUGS5_RS00220	COG2274	protein secretion by the type I secretion system
SMUGS5_RS00225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMUGS5_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMUGS5_RS00240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMUGS5_RS00250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMUGS5_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMUGS5_RS00265	COG0138	bifunctional purine biosynthesis protein purh
SMUGS5_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMUGS5_RS00320	COG1794	racemase activity, acting on amino acids and derivatives
SMUGS5_RS00340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMUGS5_RS00360	COG2255	four-way junction helicase activity
SMUGS5_RS00365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMUGS5_RS00385	COG0534	Mate efflux family protein
SMUGS5_RS00390	COG3830	Belongs to the UPF0237 family
SMUGS5_RS00395	COG2848	UPF0210 protein
SMUGS5_RS00410	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMUGS5_RS00415	COG1621	beta-fructofuranosidase activity
SMUGS5_RS00415	COG3583	domain protein
SMUGS5_RS00415	COG5492	domain, Protein
SMUGS5_RS00425	COG1420	regulation of RNA biosynthetic process
SMUGS5_RS00430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMUGS5_RS00435	COG0443	Heat shock 70 kDa protein
SMUGS5_RS00440	COG0484	heat shock protein binding
SMUGS5_RS00445	COG0101	tRNA pseudouridine synthase activity
SMUGS5_RS00450	COG0351	phosphomethylpyrimidine kinase
SMUGS5_RS00455	COG4720	Psort location CytoplasmicMembrane, score
SMUGS5_RS00460	COG4475	Protein of unknown function (DUF436)
SMUGS5_RS00465	COG0668	transmembrane transport
SMUGS5_RS00475	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMUGS5_RS00480	COG3343	RNA polymerase activity
SMUGS5_RS00485	COG0504	CTP synthase activity
SMUGS5_RS00495	COG0191	fructose-bisphosphate aldolase activity
SMUGS5_RS00505	COG3715	PTS system
SMUGS5_RS00545	COG1396	sequence-specific DNA binding
SMUGS5_RS00555	COG1105	Belongs to the carbohydrate kinase PfkB family
SMUGS5_RS00560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUGS5_RS00560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUGS5_RS00560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUGS5_RS00565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUGS5_RS00565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUGS5_RS00565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUGS5_RS00570	COG3684	Belongs to the aldolase LacD family
SMUGS5_RS00590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMUGS5_RS00595	COG0534	Mate efflux family protein
SMUGS5_RS00600	COG2176	DNA-directed DNA polymerase activity
SMUGS5_RS00605	COG1846	Transcriptional regulator
SMUGS5_RS00610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMUGS5_RS00615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMUGS5_RS00620	COG0022	dehydrogenase e1 component
SMUGS5_RS00620	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMUGS5_RS00635	COG0095	Lipoate-protein ligase
SMUGS5_RS00640	COG1473	amidohydrolase
SMUGS5_RS00645	COG0477	Major facilitator Superfamily
SMUGS5_RS00650	COG1309	transcriptional regulator
SMUGS5_RS00655	COG0583	DNA-binding transcription factor activity
SMUGS5_RS00665	COG0281	malic enzyme
SMUGS5_RS00670	COG0679	Auxin Efflux Carrier
SMUGS5_RS00675	COG2140	Oxalate decarboxylase
SMUGS5_RS00690	COG0242	peptide deformylase activity
SMUGS5_RS00695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUGS5_RS00705	COG1012	belongs to the aldehyde dehydrogenase family
SMUGS5_RS00705	COG1454	alcohol dehydrogenase
SMUGS5_RS00730	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMUGS5_RS00735	COG1185	polyribonucleotide nucleotidyltransferase activity
SMUGS5_RS00745	COG1045	serine acetyltransferase
SMUGS5_RS00750	COG0215	cysteine-tRNA ligase activity
SMUGS5_RS00755	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SMUGS5_RS00760	COG5504	Zn-dependent protease
SMUGS5_RS00780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMUGS5_RS00800	COG1476	TRANSCRIPTIONal
SMUGS5_RS00805	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMUGS5_RS00810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMUGS5_RS00830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUGS5_RS00840	COG3976	FMN-binding domain protein
SMUGS5_RS00840	COG1053	succinate dehydrogenase
SMUGS5_RS00840	COG0431	NADPH-dependent FMN reductase
SMUGS5_RS00845	COG0431	NADPH-dependent FMN reductase
SMUGS5_RS00845	COG1053	succinate dehydrogenase
SMUGS5_RS00845	COG3976	FMN-binding domain protein
SMUGS5_RS00865	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMUGS5_RS00875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMUGS5_RS00880	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMUGS5_RS00970	COG0582	viral genome integration into host DNA
SMUGS5_RS01005	COG0028	Belongs to the TPP enzyme family
SMUGS5_RS01010	COG0440	acetolactate synthase activity
SMUGS5_RS01015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMUGS5_RS01020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMUGS5_RS01030	COG1309	transcriptional regulator
SMUGS5_RS01050	COG1126	abc transporter atp-binding protein
SMUGS5_RS01055	COG0765	amino acid transport
SMUGS5_RS01065	COG1968	undecaprenyl-diphosphatase activity
SMUGS5_RS01070	COG4862	establishment of competence for transformation
SMUGS5_RS01075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUGS5_RS01085	COG0719	Fe-S assembly protein
SMUGS5_RS01090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMUGS5_RS01100	COG0719	Fe-S assembly protein
SMUGS5_RS01115	COG4166	transmembrane transport
SMUGS5_RS01120	COG0601	transmembrane transport
SMUGS5_RS01125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMUGS5_RS01130	COG0444	Belongs to the ABC transporter superfamily
SMUGS5_RS01135	COG4608	Belongs to the ABC transporter superfamily
SMUGS5_RS01150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMUGS5_RS01155	COG0531	amino acid
SMUGS5_RS01160	COG2957	Belongs to the agmatine deiminase family
SMUGS5_RS01170	COG2918	glutathione biosynthetic process
SMUGS5_RS01170	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMUGS5_RS01175	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMUGS5_RS01190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUGS5_RS01200	COG3623	hexulose-6-phosphate isomerase
SMUGS5_RS01235	COG2274	protein secretion by the type I secretion system
SMUGS5_RS01255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMUGS5_RS01285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUGS5_RS01285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMUGS5_RS01290	COG1832	CoA-binding protein
SMUGS5_RS01300	COG0343	queuine tRNA-ribosyltransferase activity
SMUGS5_RS01315	COG1234	tRNA 3'-trailer cleavage
SMUGS5_RS01330	COG0166	Belongs to the GPI family
SMUGS5_RS01340	COG3711	transcriptional antiterminator
SMUGS5_RS01340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUGS5_RS01350	COG3730	PTS system glucitol sorbitol-specific
SMUGS5_RS01355	COG3732	PTS system glucitol sorbitol-specific
SMUGS5_RS01370	COG2171	N-acyltransferase activity
SMUGS5_RS01375	COG1473	amidohydrolase
SMUGS5_RS01380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMUGS5_RS01385	COG0705	Rhomboid family
SMUGS5_RS01385	COG0457	Tetratricopeptide repeat
SMUGS5_RS01390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMUGS5_RS01395	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMUGS5_RS01400	COG0756	dUTP diphosphatase activity
SMUGS5_RS01425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMUGS5_RS01430	COG1827	regulation of RNA biosynthetic process
SMUGS5_RS01445	COG0137	argininosuccinate synthase activity
SMUGS5_RS01450	COG0165	Argininosuccinate lyase
SMUGS5_RS01455	COG0594	ribonuclease P activity
SMUGS5_RS01460	COG0706	membrane insertase activity
SMUGS5_RS01475	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMUGS5_RS01485	COG0084	hydrolase, TatD family'
SMUGS5_RS01520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMUGS5_RS01540	COG1162	GTPase activity
SMUGS5_RS01565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMUGS5_RS01570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMUGS5_RS01575	COG0049	tRNA binding
SMUGS5_RS01580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMUGS5_RS01590	COG0126	phosphoglycerate kinase activity
SMUGS5_RS01600	COG0789	Transcriptional regulator
SMUGS5_RS01605	COG0174	glutamine synthetase
SMUGS5_RS01610	COG0069	glutamate synthase activity
SMUGS5_RS01610	COG0067	glutamate synthase
SMUGS5_RS01610	COG0070	glutamate synthase
SMUGS5_RS01615	COG0493	'glutamate synthase
SMUGS5_RS01620	COG3942	CHAP domain
SMUGS5_RS01630	COG5503	Protein of unknown function (DUF1447)
SMUGS5_RS01650	COG2226	methyltransferase
SMUGS5_RS01665	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SMUGS5_RS01680	COG0667	Aldo Keto reductase
SMUGS5_RS01685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMUGS5_RS01695	COG1214	PFAM Peptidase M22, glycoprotease
SMUGS5_RS01700	COG0456	acetyltransferase
SMUGS5_RS01705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMUGS5_RS01725	COG2081	HI0933 family
SMUGS5_RS01735	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMUGS5_RS01740	COG0582	viral genome integration into host DNA
SMUGS5_RS01755	COG2801	Transposase and inactivated derivatives
SMUGS5_RS01765	COG0583	DNA-binding transcription factor activity
SMUGS5_RS01770	COG1982	Orn Lys Arg decarboxylase major
SMUGS5_RS01775	COG0318	PFAM AMP-dependent synthetase and ligase
SMUGS5_RS01780	COG0697	spore germination
SMUGS5_RS01790	COG0166	Belongs to the GPI family
SMUGS5_RS01800	COG2936	dipeptidyl-peptidase activity
SMUGS5_RS01815	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMUGS5_RS01825	COG1882	Formate acetyltransferase
SMUGS5_RS01830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMUGS5_RS01845	COG0561	phosphatase activity
SMUGS5_RS01855	COG2252	PERMEase
SMUGS5_RS01860	COG0802	atpase or kinase
SMUGS5_RS01865	COG1316	TRANSCRIPTIONal
SMUGS5_RS01875	COG0537	adenosine 5'-monophosphoramidase activity
SMUGS5_RS01880	COG1131	(ABC) transporter
SMUGS5_RS01885	COG4473	ABC transporter
SMUGS5_RS01895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMUGS5_RS01905	COG0779	Required for maturation of 30S ribosomal subunits
SMUGS5_RS01910	COG0195	Participates in both transcription termination and antitermination
SMUGS5_RS01915	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SMUGS5_RS01925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMUGS5_RS01930	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMUGS5_RS01945	COG2217	Heavy metal translocating P-type atpase
SMUGS5_RS01955	COG0561	phosphatase activity
SMUGS5_RS01965	COG1131	(ABC) transporter
SMUGS5_RS01990	COG1924	4 iron, 4 sulfur cluster binding
SMUGS5_RS02010	COG1673	EVE domain
SMUGS5_RS02015	COG0752	glycyl-tRNA synthetase alpha subunit
SMUGS5_RS02020	COG0751	glycine-tRNA ligase activity
SMUGS5_RS02025	COG4224	UPF0291 protein
SMUGS5_RS02035	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMUGS5_RS02040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMUGS5_RS02045	COG0275	rRNA processing
SMUGS5_RS02050	COG4839	cell division protein FtsL
SMUGS5_RS02055	COG0768	penicillin binding
SMUGS5_RS02060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMUGS5_RS02070	COG0513	Belongs to the DEAD box helicase family
SMUGS5_RS02085	COG1126	abc transporter atp-binding protein
SMUGS5_RS02095	COG0492	ferredoxin-NADP+ reductase activity
SMUGS5_RS02100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SMUGS5_RS02105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMUGS5_RS02110	COG3579	cysteine-type endopeptidase activity
SMUGS5_RS02115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMUGS5_RS02120	COG3331	DNA recombination
SMUGS5_RS02125	COG4474	Belongs to the UPF0398 family
SMUGS5_RS02130	COG3599	regulation of cell shape
SMUGS5_RS02135	COG0116	Belongs to the methyltransferase superfamily
SMUGS5_RS02145	COG1854	S-ribosylhomocysteine lyase activity
SMUGS5_RS02150	COG4372	Transposase
SMUGS5_RS02150	COG1418	mRNA catabolic process
SMUGS5_RS02155	COG0194	GDP metabolic process
SMUGS5_RS02160	COG1758	RNA polymerase activity
SMUGS5_RS02165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMUGS5_RS02170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMUGS5_RS02175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMUGS5_RS02175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMUGS5_RS02200	COG2197	response regulator
SMUGS5_RS02210	COG1098	S1 RNA binding domain
SMUGS5_RS02215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMUGS5_RS02220	COG1349	DNA-binding transcription factor activity
SMUGS5_RS02225	COG1882	Formate acetyltransferase
SMUGS5_RS02245	COG1739	Uncharacterized protein family UPF0029
SMUGS5_RS02250	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SMUGS5_RS02255	COG1040	competence protein
SMUGS5_RS02300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUGS5_RS02355	COG4716	Myosin-crossreactive antigen
SMUGS5_RS02360	COG0742	ribosomal rna small subunit methyltransferase
SMUGS5_RS02365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMUGS5_RS02370	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMUGS5_RS02375	COG0737	Belongs to the 5'-nucleotidase family
SMUGS5_RS02380	COG4470	Protein conserved in bacteria
SMUGS5_RS02385	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMUGS5_RS02395	COG1132	(ABC) transporter
SMUGS5_RS02400	COG1132	(ABC) transporter
SMUGS5_RS02410	COG3804	dihydrodipicolinate reductase
SMUGS5_RS02430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMUGS5_RS02435	COG0512	Glutamine amidotransferase of anthranilate synthase
SMUGS5_RS02440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMUGS5_RS02445	COG0134	indole-3-glycerol-phosphate synthase activity
SMUGS5_RS02450	COG0135	phosphoribosylanthranilate isomerase activity
SMUGS5_RS02455	COG0133	tryptophan synthase activity
SMUGS5_RS02460	COG0159	tryptophan synthase activity
SMUGS5_RS02470	COG0783	Belongs to the Dps family
SMUGS5_RS02480	COG1940	carbohydrate kinase activity
SMUGS5_RS02485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMUGS5_RS02490	COG1217	gtp-binding protein TYPA
SMUGS5_RS02500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMUGS5_RS02505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMUGS5_RS02515	COG0849	cell division
SMUGS5_RS02525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMUGS5_RS02530	COG1799	cell septum assembly
SMUGS5_RS02540	COG2302	S4 RNA-binding domain
SMUGS5_RS02545	COG3599	regulation of cell shape
SMUGS5_RS02550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMUGS5_RS02570	COG0542	response to heat
SMUGS5_RS02575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMUGS5_RS02580	COG4703	Protein of unknown function (DUF1797)
SMUGS5_RS02585	COG0765	amino acid transport
SMUGS5_RS02590	COG1126	abc transporter atp-binding protein
SMUGS5_RS02610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMUGS5_RS02615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMUGS5_RS02620	COG1346	cytolysis
SMUGS5_RS02625	COG1380	Effector of murein hydrolase LrgA
SMUGS5_RS02630	COG3279	Response regulator of the LytR AlgR family
SMUGS5_RS02635	COG3275	phosphorelay sensor kinase activity
SMUGS5_RS02640	COG1570	exodeoxyribonuclease VII activity
SMUGS5_RS02645	COG1722	exodeoxyribonuclease VII activity
SMUGS5_RS02655	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SMUGS5_RS02660	COG1438	arginine binding
SMUGS5_RS02665	COG0497	DNA recombination
SMUGS5_RS02670	COG1307	EDD domain protein, DegV family
SMUGS5_RS02675	COG2755	lipolytic protein G-D-S-L family
SMUGS5_RS02685	COG0776	regulation of translation
SMUGS5_RS02700	COG0735	belongs to the Fur family
SMUGS5_RS02715	COG0588	phosphoglycerate mutase activity
SMUGS5_RS02720	COG0768	penicillin binding
SMUGS5_RS02725	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMUGS5_RS02730	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMUGS5_RS02740	COG0385	Bile acid
SMUGS5_RS02745	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMUGS5_RS02765	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMUGS5_RS02775	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMUGS5_RS02775	COG3064	Membrane
SMUGS5_RS02780	COG0513	Belongs to the DEAD box helicase family
SMUGS5_RS02805	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMUGS5_RS02815	COG0726	polysaccharide deacetylase
SMUGS5_RS02820	COG0204	Acyl-transferase
SMUGS5_RS02825	COG1555	photosystem II stabilization
SMUGS5_RS02825	COG1596	polysaccharide export
SMUGS5_RS02830	COG0658	competence protein
SMUGS5_RS02830	COG2333	competence protein COMEC
SMUGS5_RS02845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMUGS5_RS02870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMUGS5_RS02880	COG0363	glucosamine-6-phosphate deaminase activity
SMUGS5_RS02890	COG1187	pseudouridine synthase activity
SMUGS5_RS02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMUGS5_RS02905	COG1028	Short-chain dehydrogenase reductase Sdr
SMUGS5_RS02905	COG0604	alcohol dehydrogenase
SMUGS5_RS02905	COG3321	synthase
SMUGS5_RS02925	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMUGS5_RS02925	COG0131	Imidazoleglycerol-phosphate dehydratase
SMUGS5_RS02930	COG4122	O-methyltransferase activity
SMUGS5_RS02935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMUGS5_RS02945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMUGS5_RS02965	COG1131	(ABC) transporter
SMUGS5_RS03005	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMUGS5_RS03010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMUGS5_RS03015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMUGS5_RS03020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMUGS5_RS03025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMUGS5_RS03030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMUGS5_RS03035	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMUGS5_RS03040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMUGS5_RS03045	COG0372	Belongs to the citrate synthase family
SMUGS5_RS03050	COG0538	isocitrate dehydrogenase activity
SMUGS5_RS03060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUGS5_RS03065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMUGS5_RS03070	COG1012	belongs to the aldehyde dehydrogenase family
SMUGS5_RS03075	COG0789	Transcriptional regulator
SMUGS5_RS03080	COG0656	L-ascorbic acid biosynthetic process
SMUGS5_RS03085	COG0656	L-ascorbic acid biosynthetic process
SMUGS5_RS03100	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SMUGS5_RS03135	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMUGS5_RS03155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMUGS5_RS03160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMUGS5_RS03165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMUGS5_RS03170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMUGS5_RS03175	COG0588	phosphoglycerate mutase activity
SMUGS5_RS03185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMUGS5_RS03200	COG3859	Proton-coupled thiamine transporter YuaJ
SMUGS5_RS03220	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMUGS5_RS03225	COG0772	Belongs to the SEDS family
SMUGS5_RS03230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMUGS5_RS03235	COG0149	triose-phosphate isomerase activity
SMUGS5_RS03255	COG1078	dGTPase activity
SMUGS5_RS03275	COG0584	glycerophosphoryl diester phosphodiesterase
SMUGS5_RS03290	COG0604	alcohol dehydrogenase
SMUGS5_RS03340	COG0561	phosphatase activity
SMUGS5_RS03345	COG0561	phosphatase activity
SMUGS5_RS03350	COG0552	protein localization to endoplasmic reticulum
SMUGS5_RS03355	COG0477	Major facilitator Superfamily
SMUGS5_RS03360	COG3689	TIGRFAM TIGR03943 family protein
SMUGS5_RS03365	COG0701	Predicted permease
SMUGS5_RS03380	COG2183	response to ionizing radiation
SMUGS5_RS03385	COG3091	SprT-like family
SMUGS5_RS03395	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SMUGS5_RS03400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMUGS5_RS03425	COG0826	peptidase U32
SMUGS5_RS03430	COG0450	alkyl hydroperoxide reductase
SMUGS5_RS03445	COG4443	Transcriptional Coactivator p15 (PC4)
SMUGS5_RS03450	COG1914	H( )-stimulated, divalent metal cation uptake system
SMUGS5_RS03460	COG5263	repeat protein
SMUGS5_RS03460	COG0366	Alpha amylase catalytic
SMUGS5_RS03465	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMUGS5_RS03485	COG1368	sulfuric ester hydrolase activity
SMUGS5_RS03490	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMUGS5_RS03495	COG0710	3-dehydroquinate dehydratase activity
SMUGS5_RS03500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMUGS5_RS03505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMUGS5_RS03510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMUGS5_RS03515	COG0287	Prephenate dehydrogenase
SMUGS5_RS03520	COG3679	Belongs to the UPF0342 family
SMUGS5_RS03525	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMUGS5_RS03530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMUGS5_RS03535	COG0077	Prephenate dehydratase
SMUGS5_RS03545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMUGS5_RS03555	COG0477	Major facilitator Superfamily
SMUGS5_RS03570	COG0656	L-ascorbic acid biosynthetic process
SMUGS5_RS03575	COG2207	Transcriptional regulator
SMUGS5_RS03620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMUGS5_RS03630	COG0488	(ABC) transporter
SMUGS5_RS03635	COG1126	abc transporter atp-binding protein
SMUGS5_RS03650	COG0556	nucleotide-excision repair
SMUGS5_RS03670	COG1051	belongs to the nudix hydrolase family
SMUGS5_RS03675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUGS5_RS03685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUGS5_RS03695	COG1970	mechanosensitive ion channel activity
SMUGS5_RS03705	COG0358	DNA primase activity
SMUGS5_RS03710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMUGS5_RS03715	COG2151	metal-sulfur cluster biosynthetic enzyme
SMUGS5_RS03720	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMUGS5_RS03730	COG1216	Glycosyl transferase, family 2
SMUGS5_RS03755	COG1368	sulfuric ester hydrolase activity
SMUGS5_RS03765	COG0463	Glycosyl transferase, family 2
SMUGS5_RS03780	COG3942	CHAP domain
SMUGS5_RS03785	COG0656	L-ascorbic acid biosynthetic process
SMUGS5_RS03790	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMUGS5_RS03795	COG0285	dihydrofolate synthase activity
SMUGS5_RS03805	COG1104	cysteine desulfurase activity
SMUGS5_RS03810	COG0301	tRNA thio-modification
SMUGS5_RS03830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMUGS5_RS03840	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMUGS5_RS03850	COG2816	NAD+ diphosphatase activity
SMUGS5_RS03855	COG0583	DNA-binding transcription factor activity
SMUGS5_RS03860	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMUGS5_RS03865	COG0564	pseudouridine synthase activity
SMUGS5_RS03875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SMUGS5_RS03885	COG0540	Belongs to the ATCase OTCase family
SMUGS5_RS03890	COG0505	Belongs to the CarA family
SMUGS5_RS03895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMUGS5_RS03905	COG1136	(ABC) transporter
SMUGS5_RS03910	COG0577	efflux transmembrane transporter activity
SMUGS5_RS03915	COG0228	four-way junction DNA binding
SMUGS5_RS03920	COG1837	Belongs to the UPF0109 family
SMUGS5_RS03925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMUGS5_RS03930	COG0336	Belongs to the RNA methyltransferase TrmD family
SMUGS5_RS03935	COG0492	ferredoxin-NADP+ reductase activity
SMUGS5_RS03940	COG1349	DNA-binding transcription factor activity
SMUGS5_RS03945	COG1105	Belongs to the carbohydrate kinase PfkB family
SMUGS5_RS03950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUGS5_RS03950	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUGS5_RS03950	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMUGS5_RS03955	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMUGS5_RS03960	COG0646	methionine synthase
SMUGS5_RS03960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMUGS5_RS03965	COG2801	Transposase and inactivated derivatives
SMUGS5_RS03975	COG2207	Transcriptional regulator
SMUGS5_RS03980	COG3345	alpha-galactosidase
SMUGS5_RS03985	COG1653	transport
SMUGS5_RS03990	COG1175	transmembrane transport
SMUGS5_RS03995	COG0395	ABC-type sugar transport system, permease component
SMUGS5_RS04000	COG0366	Alpha amylase catalytic
SMUGS5_RS04005	COG3842	ATPase activity
SMUGS5_RS04010	COG0366	Alpha amylase catalytic
SMUGS5_RS04015	COG1609	Transcriptional regulator
SMUGS5_RS04020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMUGS5_RS04025	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SMUGS5_RS04030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMUGS5_RS04045	COG1131	(ABC) transporter
SMUGS5_RS04060	COG1307	EDD domain protein, DegV family
SMUGS5_RS04065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMUGS5_RS04070	COG0617	tRNA 3'-terminal CCA addition
SMUGS5_RS04075	COG0488	(ABC) transporter
SMUGS5_RS04100	COG5263	repeat protein
SMUGS5_RS04100	COG0366	Alpha amylase catalytic
SMUGS5_RS04110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMUGS5_RS04120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMUGS5_RS04125	COG0602	queuosine metabolic process
SMUGS5_RS04135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMUGS5_RS04150	COG1132	(ABC) transporter
SMUGS5_RS04155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMUGS5_RS04165	COG2357	RelA SpoT domain protein
SMUGS5_RS04170	COG0745	RESPONSE REGULATOR receiver
SMUGS5_RS04180	COG3759	membrane
SMUGS5_RS04185	COG0583	DNA-binding transcription factor activity
SMUGS5_RS04195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUGS5_RS04200	COG0765	amino acid transport
SMUGS5_RS04205	COG0765	amino acid transport
SMUGS5_RS04210	COG1126	abc transporter atp-binding protein
SMUGS5_RS04225	COG1304	FMN binding
SMUGS5_RS04230	COG1272	protein, Hemolysin III
SMUGS5_RS04245	COG3425	synthase
SMUGS5_RS04250	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMUGS5_RS04255	COG3201	nicotinamide mononucleotide transporter
SMUGS5_RS04260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMUGS5_RS04270	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMUGS5_RS04275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMUGS5_RS04280	COG0833	amino acid
SMUGS5_RS04285	COG2040	homocysteine
SMUGS5_RS04290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMUGS5_RS04310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMUGS5_RS04315	COG0222	ribosome binding
SMUGS5_RS04325	COG1960	acyl-CoA dehydrogenase activity
SMUGS5_RS04330	COG0726	polysaccharide deacetylase
SMUGS5_RS04340	COG0083	homoserine kinase activity
SMUGS5_RS04345	COG0285	dihydrofolate synthase activity
SMUGS5_RS04350	COG0302	gtp cyclohydrolase
SMUGS5_RS04370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMUGS5_RS04375	COG3842	ATPase activity
SMUGS5_RS04380	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMUGS5_RS04385	COG1177	transmembrane transport
SMUGS5_RS04395	COG3711	transcriptional antiterminator
SMUGS5_RS04400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUGS5_RS04400	COG1263	PTS System
SMUGS5_RS04400	COG2190	(PTS) system
SMUGS5_RS04430	COG4932	domain protein
SMUGS5_RS04435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMUGS5_RS04445	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMUGS5_RS04450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMUGS5_RS04465	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMUGS5_RS04470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMUGS5_RS04475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMUGS5_RS04480	COG4605	iron ion homeostasis
SMUGS5_RS04485	COG4604	ABC transporter, ATP-binding protein
SMUGS5_RS04490	COG4607	ABC-type enterochelin transport system periplasmic component
SMUGS5_RS04505	COG0758	DNA mediated transformation
SMUGS5_RS04510	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMUGS5_RS04515	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SMUGS5_RS04520	COG0366	Alpha amylase catalytic
SMUGS5_RS04520	COG5263	repeat protein
SMUGS5_RS04525	COG0366	Alpha amylase catalytic
SMUGS5_RS04525	COG5263	repeat protein
SMUGS5_RS04530	COG1136	(ABC) transporter
SMUGS5_RS04540	COG0745	RESPONSE REGULATOR receiver
SMUGS5_RS04545	COG0642	Histidine kinase
SMUGS5_RS04550	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMUGS5_RS04555	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SMUGS5_RS04565	COG2851	Citrate transporter
SMUGS5_RS04575	COG0511	ligase activity, forming carbon-carbon bonds
SMUGS5_RS04580	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SMUGS5_RS04590	COG3052	prosthetic group binding
SMUGS5_RS04615	COG4974	Belongs to the 'phage' integrase family
SMUGS5_RS04620	COG1131	(ABC) transporter
SMUGS5_RS04630	COG5002	protein histidine kinase activity
SMUGS5_RS04635	COG0745	RESPONSE REGULATOR receiver
SMUGS5_RS04640	COG1442	glycosyl transferase family 8
SMUGS5_RS04645	COG4221	oxidoreductase activity
SMUGS5_RS04650	COG1131	(ABC) transporter
SMUGS5_RS04660	COG0280	phosphate acetyltransferase
SMUGS5_RS04665	COG0564	pseudouridine synthase activity
SMUGS5_RS04670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMUGS5_RS04675	COG2357	RelA SpoT domain protein
SMUGS5_RS04685	COG4116	CYTH
SMUGS5_RS04690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMUGS5_RS04695	COG1104	cysteine desulfurase activity
SMUGS5_RS04705	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMUGS5_RS04710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMUGS5_RS04730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMUGS5_RS04735	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SMUGS5_RS04745	COG3448	diguanylate cyclase activity
SMUGS5_RS04745	COG4175	Glycine betaine
SMUGS5_RS04755	COG2188	Transcriptional regulator
SMUGS5_RS04760	COG0519	Catalyzes the synthesis of GMP from XMP
SMUGS5_RS04770	COG1131	(ABC) transporter
SMUGS5_RS04790	COG1247	-acetyltransferase
SMUGS5_RS04795	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SMUGS5_RS04805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMUGS5_RS04810	COG4684	Psort location CytoplasmicMembrane, score
SMUGS5_RS04815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUGS5_RS04820	COG1132	(ABC) transporter
SMUGS5_RS04825	COG1132	(ABC) transporter
SMUGS5_RS04840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMUGS5_RS04845	COG0009	L-threonylcarbamoyladenylate synthase
SMUGS5_RS04850	COG2890	protein-(glutamine-N5) methyltransferase activity
SMUGS5_RS04855	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMUGS5_RS04860	COG1435	thymidine kinase activity
SMUGS5_RS04865	COG1942	4-Oxalocrotonate Tautomerase
SMUGS5_RS04880	COG0431	NADPH-dependent FMN reductase
SMUGS5_RS04880	COG1053	succinate dehydrogenase
SMUGS5_RS04880	COG3976	FMN-binding domain protein
SMUGS5_RS04895	COG0577	efflux transmembrane transporter activity
SMUGS5_RS04900	COG1136	(ABC) transporter
SMUGS5_RS04905	COG1174	glycine betaine transport
SMUGS5_RS04920	COG1063	alcohol dehydrogenase
SMUGS5_RS04925	COG0628	permease
SMUGS5_RS04930	COG2723	6-phospho-beta-galactosidase activity
SMUGS5_RS04940	COG0406	alpha-ribazole phosphatase activity
SMUGS5_RS04960	COG0561	phosphatase activity
SMUGS5_RS04975	COG0346	lactoylglutathione lyase activity
SMUGS5_RS04980	COG3764	Sortase (surface protein transpeptidase)
SMUGS5_RS04990	COG0039	L-malate dehydrogenase activity
SMUGS5_RS05005	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMUGS5_RS05010	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMUGS5_RS05015	COG3845	ABC transporter
SMUGS5_RS05020	COG1744	ABC transporter substrate-binding protein PnrA-like
SMUGS5_RS05025	COG0295	cytidine deaminase activity
SMUGS5_RS05030	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMUGS5_RS05035	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SMUGS5_RS05040	COG2813	Specifically methylates the guanine in position
SMUGS5_RS05045	COG1072	(Pantothenic acid kinase))
SMUGS5_RS05050	COG0268	Binds directly to 16S ribosomal RNA
SMUGS5_RS05055	COG5002	protein histidine kinase activity
SMUGS5_RS05060	COG0745	RESPONSE REGULATOR receiver
SMUGS5_RS05075	COG0704	Plays a role in the regulation of phosphate uptake
SMUGS5_RS05080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMUGS5_RS05085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMUGS5_RS05090	COG0581	inorganic phosphate transmembrane transporter activity
SMUGS5_RS05095	COG0573	inorganic phosphate transmembrane transporter activity
SMUGS5_RS05105	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SMUGS5_RS05105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMUGS5_RS05110	COG0483	inositol monophosphate 1-phosphatase activity
SMUGS5_RS05115	COG4476	Belongs to the UPF0223 family
SMUGS5_RS05120	COG1393	Belongs to the ArsC family
SMUGS5_RS05125	COG0196	riboflavin kinase activity
SMUGS5_RS05130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMUGS5_RS05135	COG2205	protein histidine kinase activity
SMUGS5_RS05140	COG0745	RESPONSE REGULATOR receiver
SMUGS5_RS05205	COG1132	(ABC) transporter
SMUGS5_RS05235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMUGS5_RS05240	COG0785	Cytochrome C biogenesis protein
SMUGS5_RS05255	COG2873	o-acetylhomoserine
SMUGS5_RS05260	COG0210	DNA helicase
SMUGS5_RS05265	COG1115	amino acid carrier protein
SMUGS5_RS05270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMUGS5_RS05275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUGS5_RS05280	COG1126	abc transporter atp-binding protein
SMUGS5_RS05285	COG0765	amino acid transport
SMUGS5_RS05290	COG2824	Alkylphosphonate utilization operon protein PhnA
SMUGS5_RS05295	COG0246	Mannitol dehydrogenase
SMUGS5_RS05300	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUGS5_RS05305	COG3711	transcriptional antiterminator
SMUGS5_RS05315	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMUGS5_RS05325	COG2261	transglycosylase associated protein
SMUGS5_RS05330	COG0469	pyruvate kinase activity
SMUGS5_RS05335	COG0205	6-phosphofructokinase activity
SMUGS5_RS05345	COG1725	Transcriptional regulator
SMUGS5_RS05350	COG1131	(ABC) transporter
SMUGS5_RS05375	COG0539	negative regulation of cytoplasmic translation
SMUGS5_RS05395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMUGS5_RS05420	COG0187	DNA topoisomerase II activity
SMUGS5_RS05425	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMUGS5_RS05440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMUGS5_RS05445	COG0765	amino acid transport
SMUGS5_RS05450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUGS5_RS05460	COG2315	Protein conserved in bacteria
SMUGS5_RS05465	COG1881	PFAM PEBP family protein
SMUGS5_RS05475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMUGS5_RS05480	COG0284	orotidine-5'-phosphate decarboxylase activity
SMUGS5_RS05485	COG0167	dihydroorotate dehydrogenase activity
SMUGS5_RS05490	COG0543	2 iron, 2 sulfur cluster binding
SMUGS5_RS05505	COG0813	purine-nucleoside phosphorylase activity
SMUGS5_RS05535	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SMUGS5_RS05540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMUGS5_RS05545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMUGS5_RS05565	COG1573	uracil-dna glycosylase
SMUGS5_RS05570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMUGS5_RS05585	COG0322	excinuclease ABC activity
SMUGS5_RS05600	COG1011	Hydrolase
SMUGS5_RS05610	COG0148	phosphopyruvate hydratase activity
SMUGS5_RS05655	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMUGS5_RS05660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMUGS5_RS05705	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMUGS5_RS05710	COG0107	imidazoleglycerol-phosphate synthase activity
SMUGS5_RS05715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMUGS5_RS05720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMUGS5_RS05730	COG0131	Imidazoleglycerol-phosphate dehydratase
SMUGS5_RS05735	COG0560	Phosphoserine phosphatase
SMUGS5_RS05740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMUGS5_RS05745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMUGS5_RS05750	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMUGS5_RS05755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMUGS5_RS05765	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SMUGS5_RS05780	COG0772	Belongs to the SEDS family
SMUGS5_RS05805	COG2814	Major facilitator Superfamily
SMUGS5_RS05815	COG0335	large ribosomal subunit rRNA binding
SMUGS5_RS05820	COG0038	chloride channel
SMUGS5_RS05830	COG0077	Prephenate dehydratase
SMUGS5_RS05830	COG1605	Chorismate mutase
SMUGS5_RS05845	COG0716	FMN binding
SMUGS5_RS05850	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMUGS5_RS05855	COG0625	glutathione transferase activity
SMUGS5_RS05860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SMUGS5_RS05865	COG0254	rRNA binding
SMUGS5_RS05880	COG2226	methyltransferase
SMUGS5_RS05895	COG1481	regulation of sporulation
SMUGS5_RS05905	COG1660	Displays ATPase and GTPase activities
SMUGS5_RS05915	COG0251	oxidation-reduction process
SMUGS5_RS05920	COG0371	Dehydrogenase
SMUGS5_RS05925	COG0017	Asparaginyl-tRNA synthetase
SMUGS5_RS05930	COG0436	Aminotransferase
SMUGS5_RS05935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMUGS5_RS05935	COG1199	ATP-dependent helicase activity
SMUGS5_RS05945	COG1122	ATPase activity
SMUGS5_RS05985	COG2177	Part of the ABC transporter FtsEX involved in
SMUGS5_RS05990	COG2884	Cell division ATP-binding protein ftsE
SMUGS5_RS06000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMUGS5_RS06090	COG1136	(ABC) transporter
SMUGS5_RS06120	COG1309	transcriptional regulator
SMUGS5_RS06135	COG1136	(ABC) transporter
SMUGS5_RS06140	COG2226	methyltransferase
SMUGS5_RS06145	COG2801	Transposase and inactivated derivatives
SMUGS5_RS06175	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMUGS5_RS06175	COG0456	acetyltransferase
SMUGS5_RS06190	COG0066	3-isopropylmalate dehydratase activity
SMUGS5_RS06195	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMUGS5_RS06200	COG0473	3-isopropylmalate dehydrogenase activity
SMUGS5_RS06210	COG0572	uridine kinase
SMUGS5_RS06225	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMUGS5_RS06250	COG0481	GTPase activity
SMUGS5_RS06275	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMUGS5_RS06295	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMUGS5_RS06300	COG1518	maintenance of DNA repeat elements
SMUGS5_RS06305	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SMUGS5_RS06320	COG3976	FMN-binding domain protein
SMUGS5_RS06320	COG1053	succinate dehydrogenase
SMUGS5_RS06330	COG0577	efflux transmembrane transporter activity
SMUGS5_RS06330	COG1136	(ABC) transporter
SMUGS5_RS06340	COG0647	UMP catabolic process
SMUGS5_RS06345	COG1051	belongs to the nudix hydrolase family
SMUGS5_RS06355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMUGS5_RS06365	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMUGS5_RS06370	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMUGS5_RS06375	COG0022	dehydrogenase e1 component
SMUGS5_RS06380	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMUGS5_RS06390	COG0542	response to heat
SMUGS5_RS06395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMUGS5_RS06405	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SMUGS5_RS06410	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMUGS5_RS06415	COG3442	glutamine amidotransferase
SMUGS5_RS06420	COG0488	(ABC) transporter
SMUGS5_RS06430	COG1215	transferase activity, transferring glycosyl groups
SMUGS5_RS06445	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMUGS5_RS06455	COG4808	Protein conserved in bacteria
SMUGS5_RS06470	COG3842	ATPase activity
SMUGS5_RS06485	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SMUGS5_RS06495	COG3527	Alpha-acetolactate decarboxylase
SMUGS5_RS06500	COG0028	Belongs to the TPP enzyme family
SMUGS5_RS06510	COG0628	permease
SMUGS5_RS06515	COG1051	belongs to the nudix hydrolase family
SMUGS5_RS06525	COG1088	dTDP-glucose 4,6-dehydratase activity
SMUGS5_RS06535	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMUGS5_RS06545	COG2384	SAM-dependent methyltransferase
SMUGS5_RS06555	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SMUGS5_RS06560	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMUGS5_RS06580	COG2378	regulation of single-species biofilm formation
SMUGS5_RS06585	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SMUGS5_RS06585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMUGS5_RS06590	COG0300	oxidoreductase activity
SMUGS5_RS06595	COG1234	tRNA 3'-trailer cleavage
SMUGS5_RS06605	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMUGS5_RS06610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMUGS5_RS06665	COG2723	6-phospho-beta-galactosidase activity
SMUGS5_RS06670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUGS5_RS06670	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUGS5_RS06675	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMUGS5_RS06680	COG3684	Belongs to the aldolase LacD family
SMUGS5_RS06685	COG1105	Belongs to the carbohydrate kinase PfkB family
SMUGS5_RS06690	COG0698	ribose 5-phosphate isomerase
SMUGS5_RS06695	COG0698	ribose 5-phosphate isomerase
SMUGS5_RS06700	COG1349	DNA-binding transcription factor activity
SMUGS5_RS06705	COG1074	ATP-dependent DNA helicase activity
SMUGS5_RS06710	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SMUGS5_RS06720	COG1518	maintenance of DNA repeat elements
SMUGS5_RS06735	COG1857	crispr-associated protein
SMUGS5_RS06785	COG1396	sequence-specific DNA binding
SMUGS5_RS06790	COG0072	phenylalanine-tRNA ligase activity
SMUGS5_RS06790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUGS5_RS06800	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMUGS5_RS06805	COG1196	nuclear chromosome segregation
SMUGS5_RS06810	COG0571	ribonuclease III activity
SMUGS5_RS06815	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMUGS5_RS06820	COG5002	protein histidine kinase activity
SMUGS5_RS06825	COG0745	RESPONSE REGULATOR receiver
SMUGS5_RS06830	COG1126	abc transporter atp-binding protein
SMUGS5_RS06835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUGS5_RS06840	COG0765	amino acid transport
SMUGS5_RS06845	COG0765	amino acid transport
SMUGS5_RS06860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMUGS5_RS06870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMUGS5_RS06875	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMUGS5_RS06880	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMUGS5_RS06885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMUGS5_RS06890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMUGS5_RS06895	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMUGS5_RS06900	COG0356	it plays a direct role in the translocation of protons across the membrane
SMUGS5_RS06910	COG0058	SHG alpha-glucan phosphorylase activity
SMUGS5_RS06915	COG0297	glycogen (starch) synthase activity
SMUGS5_RS06920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMUGS5_RS06925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMUGS5_RS06930	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMUGS5_RS06940	COG1523	belongs to the glycosyl hydrolase 13 family
SMUGS5_RS06945	COG1597	lipid kinase activity
SMUGS5_RS06950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMUGS5_RS06955	COG4708	membrane
SMUGS5_RS06965	COG2197	response regulator
SMUGS5_RS06970	COG4585	Histidine kinase
SMUGS5_RS06980	COG1131	(ABC) transporter
SMUGS5_RS07000	COG1295	ribonuclease BN
SMUGS5_RS07010	COG4109	DRTGG domain
SMUGS5_RS07030	COG0569	domain protein
SMUGS5_RS07035	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMUGS5_RS07040	COG0058	SHG alpha-glucan phosphorylase activity
SMUGS5_RS07045	COG1640	4-alpha-glucanotransferase
SMUGS5_RS07050	COG1609	Transcriptional regulator
SMUGS5_RS07060	COG1175	transmembrane transport
SMUGS5_RS07065	COG3833	ABC-type maltose transport systems, permease component
SMUGS5_RS07070	COG3842	ATPase activity
SMUGS5_RS07075	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMUGS5_RS07080	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMUGS5_RS07120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMUGS5_RS07125	COG1956	GAF domain-containing protein
SMUGS5_RS07130	COG4716	Myosin-crossreactive antigen
SMUGS5_RS07140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMUGS5_RS07155	COG0438	transferase activity, transferring glycosyl groups
SMUGS5_RS07170	COG1609	Transcriptional regulator
SMUGS5_RS07190	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUGS5_RS07200	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMUGS5_RS07205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMUGS5_RS07205	COG3711	transcriptional antiterminator
SMUGS5_RS07210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMUGS5_RS07215	COG2723	6-phospho-beta-galactosidase activity
SMUGS5_RS07220	COG0778	Nitroreductase
SMUGS5_RS07225	COG0346	lactoylglutathione lyase activity
SMUGS5_RS07230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMUGS5_RS07235	COG0557	exoribonuclease II activity
SMUGS5_RS07245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMUGS5_RS07250	COG2814	Major facilitator Superfamily
SMUGS5_RS07255	COG2264	protein methyltransferase activity
SMUGS5_RS07260	COG0237	dephospho-CoA kinase activity
SMUGS5_RS07265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMUGS5_RS07280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMUGS5_RS07285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMUGS5_RS07290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMUGS5_RS07295	COG1702	phosphate starvation-inducible protein PhoH
SMUGS5_RS07300	COG4479	Belongs to the UPF0346 family
SMUGS5_RS07305	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMUGS5_RS07315	COG0233	cytoplasmic translational termination
SMUGS5_RS07320	COG0528	UMP kinase activity
SMUGS5_RS07325	COG0081	regulation of translation
SMUGS5_RS07330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMUGS5_RS07340	COG1674	ftsk spoiiie
SMUGS5_RS07365	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMUGS5_RS07380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUGS5_RS07380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUGS5_RS07415	COG0640	Transcriptional regulator
SMUGS5_RS07425	COG0708	Exodeoxyribonuclease III
SMUGS5_RS07430	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMUGS5_RS07435	COG1393	Belongs to the ArsC family
SMUGS5_RS07440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMUGS5_RS07445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMUGS5_RS07450	COG0454	-acetyltransferase
SMUGS5_RS07460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMUGS5_RS07465	COG0347	Belongs to the P(II) protein family
SMUGS5_RS07470	COG0004	ammonium transporteR
SMUGS5_RS07480	COG4467	Involved in initiation control of chromosome replication
SMUGS5_RS07485	COG1774	PSP1 C-terminal conserved region
SMUGS5_RS07490	COG0470	DNA polymerase III
SMUGS5_RS07495	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMUGS5_RS07500	COG0517	IMP dehydrogenase activity
SMUGS5_RS07520	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMUGS5_RS07530	COG4471	UPF0298 protein
SMUGS5_RS07540	COG0740	serine-type endopeptidase activity
SMUGS5_RS07545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMUGS5_RS07550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMUGS5_RS07560	COG2244	polysaccharide biosynthetic process
SMUGS5_RS07565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMUGS5_RS07590	COG0693	protein deglycase activity
SMUGS5_RS07595	COG2378	regulation of single-species biofilm formation
SMUGS5_RS07605	COG1227	inorganic diphosphatase activity
SMUGS5_RS07615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMUGS5_RS07620	COG1696	Membrane protein involved in D-alanine export
SMUGS5_RS07625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMUGS5_RS07630	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMUGS5_RS07635	COG1253	flavin adenine dinucleotide binding
SMUGS5_RS07640	COG0628	permease
SMUGS5_RS07645	COG1119	ATPase activity
SMUGS5_RS07650	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SMUGS5_RS07655	COG1242	4 iron, 4 sulfur cluster binding
SMUGS5_RS07660	COG1346	cytolysis
SMUGS5_RS07665	COG1380	Effector of murein hydrolase LrgA
SMUGS5_RS07670	COG0671	phosphoesterase, PA-phosphatase related
SMUGS5_RS07675	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SMUGS5_RS07700	COG0569	domain protein
SMUGS5_RS07705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMUGS5_RS07710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMUGS5_RS07715	COG1187	pseudouridine synthase activity
SMUGS5_RS07720	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMUGS5_RS07725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMUGS5_RS07750	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMUGS5_RS07755	COG3763	UPF0154 protein
SMUGS5_RS07760	COG0019	diaminopimelate decarboxylase activity
SMUGS5_RS07780	COG1254	Belongs to the acylphosphatase family
SMUGS5_RS07785	COG0706	membrane insertase activity
SMUGS5_RS07790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMUGS5_RS07805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMUGS5_RS07815	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMUGS5_RS07830	COG0439	Biotin carboxylase
SMUGS5_RS07835	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMUGS5_RS07845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMUGS5_RS07850	COG1028	Short-chain dehydrogenase reductase Sdr
SMUGS5_RS07855	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMUGS5_RS07870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMUGS5_RS07875	COG1846	Transcriptional regulator
SMUGS5_RS07880	COG1024	Enoyl-CoA hydratase
SMUGS5_RS07885	COG0546	phosphoglycolate phosphatase activity
SMUGS5_RS07890	COG0527	aspartate kinase activity
SMUGS5_RS07965	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMUGS5_RS08020	COG0525	valine-tRNA ligase activity
SMUGS5_RS08030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMUGS5_RS08055	COG1780	Probably involved in ribonucleotide reductase function
SMUGS5_RS08060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMUGS5_RS08065	COG2137	regulation of response to DNA damage stimulus
SMUGS5_RS08070	COG3557	Belongs to the UPF0374 family
SMUGS5_RS08125	COG0442	prolyl-tRNA aminoacylation
SMUGS5_RS08135	COG4589	Belongs to the CDS family
SMUGS5_RS08140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMUGS5_RS08145	COG1862	Preprotein translocase
SMUGS5_RS08155	COG0217	transcriptional regulatory protein
SMUGS5_RS08160	COG0789	Transcriptional regulator
SMUGS5_RS08165	COG1323	Belongs to the UPF0348 family
SMUGS5_RS08180	COG2226	methyltransferase
SMUGS5_RS08185	COG0799	negative regulation of ribosome biogenesis
SMUGS5_RS08190	COG1713	HD superfamily hydrolase involved in NAD metabolism
SMUGS5_RS08195	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMUGS5_RS08200	COG1534	Rna-binding protein
SMUGS5_RS08205	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMUGS5_RS08210	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SMUGS5_RS08230	COG1819	glycosyl
SMUGS5_RS08235	COG0697	spore germination
SMUGS5_RS08240	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMUGS5_RS08245	COG0154	amidase activity
SMUGS5_RS08250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMUGS5_RS08255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMUGS5_RS08260	COG1335	isochorismatase
SMUGS5_RS08265	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SMUGS5_RS08270	COG0436	Aminotransferase
SMUGS5_RS08275	COG1268	BioY protein
SMUGS5_RS08285	COG0561	phosphatase activity
SMUGS5_RS08290	COG0252	asparaginase activity
SMUGS5_RS08300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMUGS5_RS08305	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMUGS5_RS08310	COG0736	holo-[acyl-carrier-protein] synthase activity
SMUGS5_RS08315	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMUGS5_RS08320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMUGS5_RS08325	COG0653	protein targeting
SMUGS5_RS08330	COG1482	cell wall glycoprotein biosynthetic process
SMUGS5_RS08335	COG1940	carbohydrate kinase activity
SMUGS5_RS08340	COG1263	PTS System
SMUGS5_RS08340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUGS5_RS08340	COG2190	(PTS) system
SMUGS5_RS08350	COG1609	Transcriptional regulator
SMUGS5_RS08355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMUGS5_RS08365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMUGS5_RS08370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMUGS5_RS08375	COG2131	deaminase
SMUGS5_RS08380	COG0006	proline dipeptidase activity
SMUGS5_RS08420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMUGS5_RS08425	COG0629	single-stranded DNA binding
SMUGS5_RS08430	COG0360	Binds together with S18 to 16S ribosomal RNA
SMUGS5_RS08440	COG1194	a g-specific adenine glycosylase
SMUGS5_RS08445	COG1063	alcohol dehydrogenase
SMUGS5_RS08450	COG3118	belongs to the thioredoxin family
SMUGS5_RS08455	COG1193	negative regulation of DNA recombination
SMUGS5_RS08470	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMUGS5_RS08475	COG0681	Belongs to the peptidase S26 family
SMUGS5_RS08480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMUGS5_RS08495	COG3715	PTS system
SMUGS5_RS08500	COG3716	PTS system mannose fructose sorbose family IID component
SMUGS5_RS08505	COG2274	protein secretion by the type I secretion system
SMUGS5_RS08525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMUGS5_RS08590	COG3290	protein histidine kinase activity
SMUGS5_RS08600	COG0586	Pfam SNARE associated Golgi protein
SMUGS5_RS08610	COG1160	GTP binding
SMUGS5_RS08615	COG1484	DNA-dependent DNA replication
SMUGS5_RS08625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMUGS5_RS08630	COG0745	RESPONSE REGULATOR receiver
SMUGS5_RS08645	COG1136	(ABC) transporter
SMUGS5_RS08650	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMUGS5_RS08655	COG0501	Belongs to the peptidase M48B family
SMUGS5_RS08660	COG1704	LemA family
SMUGS5_RS08665	COG0357	Ribosomal RNA small subunit methyltransferase G
SMUGS5_RS08675	COG1122	ATPase activity
SMUGS5_RS08680	COG4720	Psort location CytoplasmicMembrane, score
SMUGS5_RS08690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMUGS5_RS08700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMUGS5_RS08705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMUGS5_RS08710	COG1464	Belongs to the NlpA lipoprotein family
SMUGS5_RS08715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMUGS5_RS08750	COG1131	(ABC) transporter
SMUGS5_RS08760	COG0495	leucyl-tRNA aminoacylation
SMUGS5_RS08790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMUGS5_RS08795	COG0564	pseudouridine synthase activity
SMUGS5_RS08805	COG0459	protein refolding
SMUGS5_RS08810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMUGS5_RS08820	COG3716	PTS system mannose fructose sorbose family IID component
SMUGS5_RS08825	COG3715	PTS system
SMUGS5_RS08845	COG2197	response regulator
SMUGS5_RS08850	COG4585	Histidine kinase
SMUGS5_RS08870	COG1846	Transcriptional regulator
SMUGS5_RS08875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMUGS5_RS08880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMUGS5_RS08890	COG1363	Peptidase, m42
SMUGS5_RS08895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMUGS5_RS08920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMUGS5_RS08925	COG0827	DNA restriction-modification system
SMUGS5_RS08955	COG1459	type II secretion system
SMUGS5_RS08960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMUGS5_RS08970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMUGS5_RS08975	COG0085	RNA polymerase activity
SMUGS5_RS08980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMUGS5_RS08985	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMUGS5_RS08990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMUGS5_RS08995	COG1121	(ABC) transporter
SMUGS5_RS09005	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMUGS5_RS09045	COG0203	ribosomal protein L17
SMUGS5_RS09050	COG0202	RNA polymerase activity
SMUGS5_RS09055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMUGS5_RS09060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMUGS5_RS09070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMUGS5_RS09075	COG0563	adenylate kinase activity
SMUGS5_RS09080	COG0201	protein transport
SMUGS5_RS09085	COG0200	Binds to the 23S rRNA
SMUGS5_RS09090	COG1841	ribosomal large subunit assembly
SMUGS5_RS09095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMUGS5_RS09105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMUGS5_RS09110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMUGS5_RS09115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMUGS5_RS09120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMUGS5_RS09125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMUGS5_RS09130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMUGS5_RS09135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMUGS5_RS09140	COG0255	Belongs to the universal ribosomal protein uL29 family
SMUGS5_RS09145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMUGS5_RS09150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMUGS5_RS09155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMUGS5_RS09165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMUGS5_RS09170	COG0089	rRNA binding
SMUGS5_RS09180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMUGS5_RS09185	COG0051	transcription antitermination factor activity, RNA binding
SMUGS5_RS09195	COG1621	beta-fructofuranosidase activity
SMUGS5_RS09200	COG0542	response to heat
SMUGS5_RS09205	COG4463	regulation of RNA biosynthetic process
SMUGS5_RS09210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMUGS5_RS09215	COG0052	Belongs to the universal ribosomal protein uS2 family
SMUGS5_RS09230	COG1619	proteins homologs of microcin C7 resistance protein MccF
SMUGS5_RS09235	COG3590	peptidase
SMUGS5_RS09240	COG0366	Alpha amylase catalytic
SMUGS5_RS09245	COG1263	PTS System
SMUGS5_RS09245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUGS5_RS09250	COG2188	Transcriptional regulator
SMUGS5_RS09255	COG5297	Belongs to the glycosyl hydrolase family 6
SMUGS5_RS09260	COG1490	D-aminoacyl-tRNA deacylase activity
SMUGS5_RS09275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMUGS5_RS09275	COG2190	(PTS) system
SMUGS5_RS09275	COG1263	PTS System
SMUGS5_RS09285	COG1609	Transcriptional regulator
SMUGS5_RS09290	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMUGS5_RS09295	COG2264	protein methyltransferase activity
SMUGS5_RS09315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMUGS5_RS09325	COG2217	Heavy metal translocating P-type atpase
SMUGS5_RS09335	COG2855	membrane
SMUGS5_RS09340	COG0583	DNA-binding transcription factor activity
SMUGS5_RS09350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMUGS5_RS09360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMUGS5_RS09370	COG0463	Glycosyl transferase, family 2
SMUGS5_RS09375	COG0428	transporter
SMUGS5_RS09380	COG3022	response to hydroperoxide
SMUGS5_RS09415	COG3906	Belongs to the UPF0473 family
SMUGS5_RS09420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMUGS5_RS09425	COG4472	Bacterial protein of unknown function (DUF965)
SMUGS5_RS09445	COG1393	Belongs to the ArsC family
SMUGS5_RS09450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMUGS5_RS09455	COG1546	Belongs to the CinA family
SMUGS5_RS09455	COG1058	Belongs to the CinA family
SMUGS5_RS09460	COG0519	Catalyzes the synthesis of GMP from XMP
SMUGS5_RS09465	COG0632	four-way junction helicase activity
SMUGS5_RS09470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMUGS5_RS09480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SMUGS5_RS09490	COG1438	arginine binding
SMUGS5_RS09510	COG0018	arginyl-trna synthetase
SMUGS5_RS09515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUGS5_RS09520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMUGS5_RS09525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMUGS5_RS09530	COG0124	histidyl-tRNA synthetase
SMUGS5_RS09535	COG0531	amino acid
SMUGS5_RS09540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SMUGS5_RS09545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMUGS5_RS09555	COG0640	Transcriptional regulator
SMUGS5_RS09580	COG0789	Transcriptional regulator
SMUGS5_RS09585	COG1028	Short-chain dehydrogenase reductase Sdr
SMUGS5_RS09610	COG2094	Belongs to the DNA glycosylase MPG family
SMUGS5_RS09625	COG1733	regulation of RNA biosynthetic process
SMUGS5_RS09635	COG1012	belongs to the aldehyde dehydrogenase family
SMUGS5_RS09640	COG0129	dihydroxy-acid dehydratase activity
SMUGS5_RS09645	COG2151	metal-sulfur cluster biosynthetic enzyme
SMUGS5_RS09665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMUGS5_RS09675	COG0305	Participates in initiation and elongation during chromosome replication
SMUGS5_RS09680	COG0359	binds to the 23S rRNA
SMUGS5_RS09690	COG0445	tRNA wobble uridine modification
SMUGS5_RS09700	COG0482	sulfurtransferase activity
SMUGS5_RS09705	COG0741	lytic transglycosylase activity
SMUGS5_RS09715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SMUGS5_RS09720	COG1122	ATPase activity
SMUGS5_RS09725	COG1122	ATPase activity
SMUGS5_RS09730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMUGS5_RS09740	COG0612	Peptidase, M16
SMUGS5_RS09755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMUGS5_RS09760	COG0517	IMP dehydrogenase activity
SMUGS5_RS09760	COG0516	GMP reductase activity
SMUGS5_RS09765	COG0180	Tryptophanyl-tRNA synthetase
SMUGS5_RS09770	COG0488	(ABC) transporter
SMUGS5_RS09800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA