locus-tag	class	description
CO204_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO204_RS00010	COG0592	DNA-directed DNA polymerase activity
CO204_RS00020	COG0012	GTP binding
CO204_RS00025	COG0193	aminoacyl-tRNA hydrolase activity
CO204_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CO204_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CO204_RS00055	COG0037	tRNA processing
CO204_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CO204_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO204_RS00070	COG0531	amino acid
CO204_RS00185	COG1792	Involved in formation and maintenance of cell shape
CO204_RS00195	COG3942	CHAP domain
CO204_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO204_RS00205	COG0436	Aminotransferase
CO204_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
CO204_RS00215	COG0416	fatty acid biosynthetic process
CO204_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO204_RS00225	COG2274	protein secretion by the type I secretion system
CO204_RS00230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CO204_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO204_RS00245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CO204_RS00250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO204_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CO204_RS00270	COG0138	bifunctional purine biosynthesis protein purh
CO204_RS00295	COG0151	Belongs to the GarS family
CO204_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CO204_RS00325	COG1794	racemase activity, acting on amino acids and derivatives
CO204_RS00340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO204_RS00360	COG2255	four-way junction helicase activity
CO204_RS00365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CO204_RS00400	COG0534	Mate efflux family protein
CO204_RS00405	COG3830	Belongs to the UPF0237 family
CO204_RS00410	COG2848	UPF0210 protein
CO204_RS00425	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO204_RS00435	COG5492	domain, Protein
CO204_RS00435	COG3583	domain protein
CO204_RS00435	COG1621	beta-fructofuranosidase activity
CO204_RS00445	COG1420	regulation of RNA biosynthetic process
CO204_RS00450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO204_RS00460	COG0443	Heat shock 70 kDa protein
CO204_RS00465	COG0484	heat shock protein binding
CO204_RS00470	COG0101	tRNA pseudouridine synthase activity
CO204_RS00475	COG0351	phosphomethylpyrimidine kinase
CO204_RS00480	COG4720	Psort location CytoplasmicMembrane, score
CO204_RS00485	COG4475	Protein of unknown function (DUF436)
CO204_RS00490	COG0668	transmembrane transport
CO204_RS00500	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO204_RS00510	COG3343	RNA polymerase activity
CO204_RS00515	COG0504	CTP synthase activity
CO204_RS00525	COG0191	fructose-bisphosphate aldolase activity
CO204_RS00535	COG3715	PTS system
CO204_RS00585	COG1396	sequence-specific DNA binding
CO204_RS00595	COG1105	Belongs to the carbohydrate kinase PfkB family
CO204_RS00600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO204_RS00600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO204_RS00600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO204_RS00605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO204_RS00605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO204_RS00605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO204_RS00610	COG3684	Belongs to the aldolase LacD family
CO204_RS00630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CO204_RS00635	COG0534	Mate efflux family protein
CO204_RS00640	COG2176	DNA-directed DNA polymerase activity
CO204_RS00645	COG1846	Transcriptional regulator
CO204_RS00650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CO204_RS00660	COG0022	dehydrogenase e1 component
CO204_RS00660	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO204_RS00675	COG0095	Lipoate-protein ligase
CO204_RS00680	COG1473	amidohydrolase
CO204_RS00685	COG0477	Major facilitator Superfamily
CO204_RS00690	COG1309	transcriptional regulator
CO204_RS00695	COG0583	DNA-binding transcription factor activity
CO204_RS00705	COG0281	malic enzyme
CO204_RS00710	COG0679	Auxin Efflux Carrier
CO204_RS00715	COG2140	Oxalate decarboxylase
CO204_RS00730	COG0242	peptide deformylase activity
CO204_RS00735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO204_RS00745	COG1454	alcohol dehydrogenase
CO204_RS00745	COG1012	belongs to the aldehyde dehydrogenase family
CO204_RS00750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CO204_RS00770	COG1185	polyribonucleotide nucleotidyltransferase activity
CO204_RS00780	COG1045	serine acetyltransferase
CO204_RS00785	COG0215	cysteine-tRNA ligase activity
CO204_RS00790	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CO204_RS00795	COG5504	Zn-dependent protease
CO204_RS00815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO204_RS00835	COG1476	TRANSCRIPTIONal
CO204_RS00845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO204_RS00850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CO204_RS00855	COG4974	Belongs to the 'phage' integrase family
CO204_RS00875	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO204_RS00875	COG3942	CHAP domain
CO204_RS00890	COG0433	COG0433 Predicted ATPase
CO204_RS00930	COG4115	mRNA cleavage
CO204_RS00940	COG1674	ftsk spoiiie
CO204_RS00980	COG1396	sequence-specific DNA binding
CO204_RS01045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO204_RS01055	COG3976	FMN-binding domain protein
CO204_RS01055	COG1053	succinate dehydrogenase
CO204_RS01055	COG0431	NADPH-dependent FMN reductase
CO204_RS01060	COG3976	FMN-binding domain protein
CO204_RS01060	COG1053	succinate dehydrogenase
CO204_RS01060	COG0431	NADPH-dependent FMN reductase
CO204_RS01065	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO204_RS01080	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO204_RS01090	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO204_RS01095	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CO204_RS01135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CO204_RS01145	COG1121	(ABC) transporter
CO204_RS01150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO204_RS01155	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CO204_RS01160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO204_RS01165	COG0085	RNA polymerase activity
CO204_RS01170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CO204_RS01180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CO204_RS01185	COG1459	type II secretion system
CO204_RS01215	COG0827	DNA restriction-modification system
CO204_RS01220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CO204_RS01250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CO204_RS01255	COG1363	Peptidase, m42
CO204_RS01265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO204_RS01270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO204_RS01275	COG1846	Transcriptional regulator
CO204_RS01295	COG4585	Histidine kinase
CO204_RS01300	COG2197	response regulator
CO204_RS01330	COG3715	PTS system
CO204_RS01335	COG3716	PTS system mannose fructose sorbose family IID component
CO204_RS01345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CO204_RS01350	COG0459	protein refolding
CO204_RS01360	COG0564	pseudouridine synthase activity
CO204_RS01365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO204_RS01395	COG0495	leucyl-tRNA aminoacylation
CO204_RS01400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO204_RS01405	COG1464	Belongs to the NlpA lipoprotein family
CO204_RS01410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO204_RS01415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO204_RS01425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CO204_RS01435	COG4720	Psort location CytoplasmicMembrane, score
CO204_RS01440	COG1122	ATPase activity
CO204_RS01450	COG0357	Ribosomal RNA small subunit methyltransferase G
CO204_RS01455	COG1704	LemA family
CO204_RS01460	COG0501	Belongs to the peptidase M48B family
CO204_RS01465	COG4591	ABC-type transport system involved in lipoprotein release permease component
CO204_RS01470	COG1136	(ABC) transporter
CO204_RS01485	COG0745	RESPONSE REGULATOR receiver
CO204_RS01490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CO204_RS01500	COG1484	DNA-dependent DNA replication
CO204_RS01505	COG1160	GTP binding
CO204_RS01515	COG0586	Pfam SNARE associated Golgi protein
CO204_RS01540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO204_RS01560	COG3716	PTS system mannose fructose sorbose family IID component
CO204_RS01565	COG3715	PTS system
CO204_RS01580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO204_RS01585	COG0681	Belongs to the peptidase S26 family
CO204_RS01590	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO204_RS01610	COG1193	negative regulation of DNA recombination
CO204_RS01615	COG3118	belongs to the thioredoxin family
CO204_RS01620	COG1063	alcohol dehydrogenase
CO204_RS01625	COG1194	a g-specific adenine glycosylase
CO204_RS01640	COG0360	Binds together with S18 to 16S ribosomal RNA
CO204_RS01645	COG0629	single-stranded DNA binding
CO204_RS01650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CO204_RS01685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO204_RS01690	COG0006	proline dipeptidase activity
CO204_RS01695	COG2131	deaminase
CO204_RS01700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO204_RS01705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CO204_RS01715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO204_RS01720	COG1609	Transcriptional regulator
CO204_RS01725	COG1621	beta-fructofuranosidase activity
CO204_RS01730	COG2190	(PTS) system
CO204_RS01730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO204_RS01730	COG1263	PTS System
CO204_RS01735	COG1940	carbohydrate kinase activity
CO204_RS01740	COG1482	cell wall glycoprotein biosynthetic process
CO204_RS01745	COG0653	protein targeting
CO204_RS01750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CO204_RS01760	COG0736	holo-[acyl-carrier-protein] synthase activity
CO204_RS01765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CO204_RS01770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CO204_RS01780	COG0252	asparaginase activity
CO204_RS01785	COG0561	phosphatase activity
CO204_RS01795	COG1268	BioY protein
CO204_RS01800	COG0436	Aminotransferase
CO204_RS01805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CO204_RS01810	COG1335	isochorismatase
CO204_RS01815	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO204_RS01820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO204_RS01825	COG0154	amidase activity
CO204_RS01830	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO204_RS01840	COG3344	reverse transcriptase
CO204_RS01855	COG0745	RESPONSE REGULATOR receiver
CO204_RS01865	COG5002	protein histidine kinase activity
CO204_RS01925	COG0697	spore germination
CO204_RS01930	COG1819	glycosyl
CO204_RS01940	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CO204_RS01945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO204_RS01950	COG1534	Rna-binding protein
CO204_RS01955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CO204_RS01960	COG1713	HD superfamily hydrolase involved in NAD metabolism
CO204_RS01965	COG0799	negative regulation of ribosome biogenesis
CO204_RS01970	COG2226	methyltransferase
CO204_RS01985	COG1323	Belongs to the UPF0348 family
CO204_RS01990	COG0789	Transcriptional regulator
CO204_RS01995	COG0217	transcriptional regulatory protein
CO204_RS02005	COG1862	Preprotein translocase
CO204_RS02010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CO204_RS02015	COG4589	Belongs to the CDS family
CO204_RS02025	COG0442	prolyl-tRNA aminoacylation
CO204_RS02085	COG3557	Belongs to the UPF0374 family
CO204_RS02090	COG2137	regulation of response to DNA damage stimulus
CO204_RS02095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO204_RS02100	COG1780	Probably involved in ribonucleotide reductase function
CO204_RS02135	COG0525	valine-tRNA ligase activity
CO204_RS02220	COG0527	aspartate kinase activity
CO204_RS02225	COG0546	phosphoglycolate phosphatase activity
CO204_RS02230	COG1024	Enoyl-CoA hydratase
CO204_RS02235	COG1846	Transcriptional regulator
CO204_RS02240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO204_RS02255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CO204_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
CO204_RS02265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO204_RS02275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO204_RS02280	COG0439	Biotin carboxylase
CO204_RS02295	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CO204_RS02305	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CO204_RS02315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CO204_RS02320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO204_RS02325	COG0706	membrane insertase activity
CO204_RS02330	COG1254	Belongs to the acylphosphatase family
CO204_RS02335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO204_RS02350	COG0019	diaminopimelate decarboxylase activity
CO204_RS02355	COG3763	UPF0154 protein
CO204_RS02360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CO204_RS02365	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CO204_RS02380	COG0582	viral genome integration into host DNA
CO204_RS02385	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CO204_RS02390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CO204_RS02395	COG1187	pseudouridine synthase activity
CO204_RS02400	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CO204_RS02405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO204_RS02410	COG0569	domain protein
CO204_RS02435	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CO204_RS02440	COG0671	phosphoesterase, PA-phosphatase related
CO204_RS02450	COG1346	cytolysis
CO204_RS02455	COG1242	4 iron, 4 sulfur cluster binding
CO204_RS02460	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CO204_RS02465	COG1119	ATPase activity
CO204_RS02470	COG0628	permease
CO204_RS02475	COG1253	flavin adenine dinucleotide binding
CO204_RS02480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CO204_RS02490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CO204_RS02495	COG1696	Membrane protein involved in D-alanine export
CO204_RS02500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO204_RS02505	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CO204_RS02510	COG1227	inorganic diphosphatase activity
CO204_RS02520	COG2378	regulation of single-species biofilm formation
CO204_RS02525	COG0693	protein deglycase activity
CO204_RS02550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CO204_RS02555	COG2244	polysaccharide biosynthetic process
CO204_RS02560	COG0626	cystathionine gamma-synthase activity
CO204_RS02565	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CO204_RS02570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CO204_RS02575	COG0740	serine-type endopeptidase activity
CO204_RS02585	COG4471	UPF0298 protein
CO204_RS02595	COG0559	Belongs to the binding-protein-dependent transport system permease family
CO204_RS02615	COG0517	IMP dehydrogenase activity
CO204_RS02620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CO204_RS02625	COG0470	DNA polymerase III
CO204_RS02630	COG1774	PSP1 C-terminal conserved region
CO204_RS02635	COG4467	Involved in initiation control of chromosome replication
CO204_RS02645	COG0004	ammonium transporteR
CO204_RS02650	COG0347	Belongs to the P(II) protein family
CO204_RS02655	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CO204_RS02670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO204_RS02675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO204_RS02680	COG1393	Belongs to the ArsC family
CO204_RS02685	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CO204_RS02690	COG0708	Exodeoxyribonuclease III
CO204_RS02700	COG0640	Transcriptional regulator
CO204_RS02740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO204_RS02740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO204_RS02760	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO204_RS02785	COG1674	ftsk spoiiie
CO204_RS02795	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CO204_RS02800	COG0081	regulation of translation
CO204_RS02805	COG0528	UMP kinase activity
CO204_RS02810	COG0233	cytoplasmic translational termination
CO204_RS02820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO204_RS02825	COG4479	Belongs to the UPF0346 family
CO204_RS02830	COG1702	phosphate starvation-inducible protein PhoH
CO204_RS02835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CO204_RS02840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CO204_RS02845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CO204_RS02860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CO204_RS02865	COG0237	dephospho-CoA kinase activity
CO204_RS02870	COG2264	protein methyltransferase activity
CO204_RS02875	COG2814	Major facilitator Superfamily
CO204_RS02880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO204_RS02890	COG0557	exoribonuclease II activity
CO204_RS02895	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CO204_RS02900	COG2814	Major facilitator Superfamily
CO204_RS02910	COG0346	lactoylglutathione lyase activity
CO204_RS02915	COG0778	Nitroreductase
CO204_RS02925	COG2723	6-phospho-beta-galactosidase activity
CO204_RS02930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO204_RS02935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO204_RS02935	COG3711	transcriptional antiterminator
CO204_RS02940	COG1447	Phosphotransferase system cellobiose-specific component IIA
CO204_RS02950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO204_RS02970	COG1609	Transcriptional regulator
CO204_RS02985	COG0438	transferase activity, transferring glycosyl groups
CO204_RS03000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO204_RS03005	COG1956	GAF domain-containing protein
CO204_RS03010	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO204_RS03025	COG5290	Psort location Cytoplasmic, score
CO204_RS03045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO204_RS03050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO204_RS03055	COG3842	ATPase activity
CO204_RS03060	COG3833	ABC-type maltose transport systems, permease component
CO204_RS03065	COG1175	transmembrane transport
CO204_RS03135	COG1609	Transcriptional regulator
CO204_RS03140	COG1640	4-alpha-glucanotransferase
CO204_RS03145	COG0058	SHG alpha-glucan phosphorylase activity
CO204_RS03150	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CO204_RS03155	COG0569	domain protein
CO204_RS03175	COG4109	DRTGG domain
CO204_RS03185	COG1295	ribonuclease BN
CO204_RS03205	COG1131	(ABC) transporter
CO204_RS03215	COG4585	Histidine kinase
CO204_RS03220	COG2197	response regulator
CO204_RS03230	COG4708	membrane
CO204_RS03235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CO204_RS03240	COG1597	lipid kinase activity
CO204_RS03245	COG1523	belongs to the glycosyl hydrolase 13 family
CO204_RS03250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CO204_RS03255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CO204_RS03260	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CO204_RS03265	COG0297	glycogen (starch) synthase activity
CO204_RS03270	COG0058	SHG alpha-glucan phosphorylase activity
CO204_RS03280	COG0356	it plays a direct role in the translocation of protons across the membrane
CO204_RS03285	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO204_RS03290	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO204_RS03295	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CO204_RS03300	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CO204_RS03305	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CO204_RS03310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CO204_RS03320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO204_RS03335	COG0765	amino acid transport
CO204_RS03340	COG0765	amino acid transport
CO204_RS03345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO204_RS03350	COG1126	abc transporter atp-binding protein
CO204_RS03355	COG0745	RESPONSE REGULATOR receiver
CO204_RS03360	COG5002	protein histidine kinase activity
CO204_RS03365	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CO204_RS03370	COG0571	ribonuclease III activity
CO204_RS03375	COG1196	nuclear chromosome segregation
CO204_RS03380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CO204_RS03390	COG0072	phenylalanine-tRNA ligase activity
CO204_RS03390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO204_RS03395	COG1396	sequence-specific DNA binding
CO204_RS03400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CO204_RS03430	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CO204_RS03435	COG1074	ATP-dependent DNA helicase activity
CO204_RS03440	COG1349	DNA-binding transcription factor activity
CO204_RS03445	COG0698	ribose 5-phosphate isomerase
CO204_RS03450	COG0698	ribose 5-phosphate isomerase
CO204_RS03455	COG1105	Belongs to the carbohydrate kinase PfkB family
CO204_RS03460	COG3684	Belongs to the aldolase LacD family
CO204_RS03475	COG3775	system Galactitol-specific IIC component
CO204_RS03480	COG1447	Phosphotransferase system cellobiose-specific component IIA
CO204_RS03485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO204_RS03485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CO204_RS03490	COG2723	6-phospho-beta-galactosidase activity
CO204_RS03515	COG1401	restriction endodeoxyribonuclease activity
CO204_RS03545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CO204_RS03550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CO204_RS03560	COG1234	tRNA 3'-trailer cleavage
CO204_RS03565	COG0300	oxidoreductase activity
CO204_RS03570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CO204_RS03570	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CO204_RS03575	COG2378	regulation of single-species biofilm formation
CO204_RS03590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO204_RS03595	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CO204_RS03605	COG2384	SAM-dependent methyltransferase
CO204_RS03615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO204_RS03620	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CO204_RS03635	COG1088	dTDP-glucose 4,6-dehydratase activity
CO204_RS03645	COG1051	belongs to the nudix hydrolase family
CO204_RS03650	COG0628	permease
CO204_RS03660	COG0028	Belongs to the TPP enzyme family
CO204_RS03665	COG3527	Alpha-acetolactate decarboxylase
CO204_RS03670	COG1113	amino acid transport
CO204_RS03675	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CO204_RS03715	COG4808	Protein conserved in bacteria
CO204_RS03725	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CO204_RS03740	COG1215	transferase activity, transferring glycosyl groups
CO204_RS03750	COG0488	(ABC) transporter
CO204_RS03755	COG3442	glutamine amidotransferase
CO204_RS03760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO204_RS03765	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CO204_RS03775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO204_RS03780	COG0542	response to heat
CO204_RS03790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CO204_RS03795	COG0022	dehydrogenase e1 component
CO204_RS03800	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO204_RS03805	COG2249	NAD(P)H dehydrogenase (quinone) activity
CO204_RS03815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO204_RS03825	COG1051	belongs to the nudix hydrolase family
CO204_RS03830	COG0647	UMP catabolic process
CO204_RS03840	COG1136	(ABC) transporter
CO204_RS03840	COG0577	efflux transmembrane transporter activity
CO204_RS03850	COG1053	succinate dehydrogenase
CO204_RS03850	COG3976	FMN-binding domain protein
CO204_RS03865	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CO204_RS03870	COG1518	maintenance of DNA repeat elements
CO204_RS03875	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CO204_RS03895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO204_RS03920	COG0481	GTPase activity
CO204_RS03945	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CO204_RS03955	COG0673	inositol 2-dehydrogenase activity
CO204_RS03960	COG0572	uridine kinase
CO204_RS03970	COG0473	3-isopropylmalate dehydrogenase activity
CO204_RS03975	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CO204_RS03980	COG0066	3-isopropylmalate dehydratase activity
CO204_RS03995	COG0456	acetyltransferase
CO204_RS03995	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
CO204_RS04040	COG2226	methyltransferase
CO204_RS04045	COG1136	(ABC) transporter
CO204_RS04055	COG1309	transcriptional regulator
CO204_RS04075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CO204_RS04085	COG2884	Cell division ATP-binding protein ftsE
CO204_RS04090	COG2177	Part of the ABC transporter FtsEX involved in
CO204_RS04130	COG1122	ATPase activity
CO204_RS04140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO204_RS04140	COG1199	ATP-dependent helicase activity
CO204_RS04145	COG0436	Aminotransferase
CO204_RS04150	COG0017	Asparaginyl-tRNA synthetase
CO204_RS04160	COG0371	Dehydrogenase
CO204_RS04165	COG0251	oxidation-reduction process
CO204_RS04175	COG1660	Displays ATPase and GTPase activities
CO204_RS04185	COG1481	regulation of sporulation
CO204_RS04200	COG2226	methyltransferase
CO204_RS04215	COG0254	rRNA binding
CO204_RS04220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO204_RS04225	COG0625	glutathione transferase activity
CO204_RS04230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CO204_RS04235	COG0716	FMN binding
CO204_RS04250	COG1605	Chorismate mutase
CO204_RS04250	COG0077	Prephenate dehydratase
CO204_RS04255	COG0038	chloride channel
CO204_RS04260	COG0038	chloride channel
CO204_RS04265	COG0335	large ribosomal subunit rRNA binding
CO204_RS04275	COG2814	Major facilitator Superfamily
CO204_RS04300	COG0772	Belongs to the SEDS family
CO204_RS04315	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CO204_RS04330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CO204_RS04335	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CO204_RS04340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CO204_RS04345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CO204_RS04350	COG0560	Phosphoserine phosphatase
CO204_RS04355	COG0131	Imidazoleglycerol-phosphate dehydratase
CO204_RS04365	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CO204_RS04370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CO204_RS04375	COG0107	imidazoleglycerol-phosphate synthase activity
CO204_RS04380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CO204_RS04405	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CO204_RS04415	COG0732	type I restriction modification DNA specificity domain
CO204_RS04425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CO204_RS04475	COG0148	phosphopyruvate hydratase activity
CO204_RS04485	COG1011	Hydrolase
CO204_RS04495	COG0322	excinuclease ABC activity
CO204_RS04505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO204_RS04510	COG1573	uracil-dna glycosylase
CO204_RS04530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CO204_RS04535	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CO204_RS04540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CO204_RS04560	COG0813	purine-nucleoside phosphorylase activity
CO204_RS04575	COG0543	2 iron, 2 sulfur cluster binding
CO204_RS04580	COG0167	dihydroorotate dehydrogenase activity
CO204_RS04585	COG0284	orotidine-5'-phosphate decarboxylase activity
CO204_RS04590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CO204_RS04600	COG1881	PFAM PEBP family protein
CO204_RS04605	COG2315	Protein conserved in bacteria
CO204_RS04615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO204_RS04620	COG0765	amino acid transport
CO204_RS04625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CO204_RS04635	COG0737	Belongs to the 5'-nucleotidase family
CO204_RS04640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CO204_RS04645	COG0187	DNA topoisomerase II activity
CO204_RS04665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO204_RS04685	COG0539	negative regulation of cytoplasmic translation
CO204_RS04715	COG1131	(ABC) transporter
CO204_RS04720	COG1725	Transcriptional regulator
CO204_RS04730	COG0205	6-phosphofructokinase activity
CO204_RS04735	COG0469	pyruvate kinase activity
CO204_RS04740	COG2261	transglycosylase associated protein
CO204_RS04750	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO204_RS04755	COG2213	PTS system mannitol-specific
CO204_RS04760	COG3711	transcriptional antiterminator
CO204_RS04765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO204_RS04770	COG0246	Mannitol dehydrogenase
CO204_RS04775	COG2824	Alkylphosphonate utilization operon protein PhnA
CO204_RS04780	COG0765	amino acid transport
CO204_RS04785	COG1126	abc transporter atp-binding protein
CO204_RS04790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO204_RS04795	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CO204_RS04800	COG1115	amino acid carrier protein
CO204_RS04805	COG0210	DNA helicase
CO204_RS04810	COG2873	o-acetylhomoserine
CO204_RS04825	COG0785	Cytochrome C biogenesis protein
CO204_RS04830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO204_RS04855	COG2375	cellular response to nickel ion
CO204_RS04855	COG1132	(ABC) transporter
CO204_RS04860	COG1132	(ABC) transporter
CO204_RS04930	COG0745	RESPONSE REGULATOR receiver
CO204_RS04935	COG2205	protein histidine kinase activity
CO204_RS04940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO204_RS04945	COG0196	riboflavin kinase activity
CO204_RS04950	COG1393	Belongs to the ArsC family
CO204_RS04955	COG4476	Belongs to the UPF0223 family
CO204_RS04960	COG0483	inositol monophosphate 1-phosphatase activity
CO204_RS04965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO204_RS04965	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CO204_RS04975	COG0573	inorganic phosphate transmembrane transporter activity
CO204_RS04980	COG0581	inorganic phosphate transmembrane transporter activity
CO204_RS04985	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO204_RS04990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO204_RS04995	COG0704	Plays a role in the regulation of phosphate uptake
CO204_RS05010	COG0745	RESPONSE REGULATOR receiver
CO204_RS05015	COG5002	protein histidine kinase activity
CO204_RS05020	COG0268	Binds directly to 16S ribosomal RNA
CO204_RS05025	COG1072	(Pantothenic acid kinase))
CO204_RS05030	COG2813	Specifically methylates the guanine in position
CO204_RS05035	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CO204_RS05040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CO204_RS05045	COG0295	cytidine deaminase activity
CO204_RS05050	COG1744	ABC transporter substrate-binding protein PnrA-like
CO204_RS05055	COG3845	ABC transporter
CO204_RS05060	COG4603	Belongs to the binding-protein-dependent transport system permease family
CO204_RS05065	COG1079	Belongs to the binding-protein-dependent transport system permease family
CO204_RS05080	COG0039	L-malate dehydrogenase activity
CO204_RS05090	COG3764	Sortase (surface protein transpeptidase)
CO204_RS05095	COG0346	lactoylglutathione lyase activity
CO204_RS05110	COG0561	phosphatase activity
CO204_RS05120	COG0346	lactoylglutathione lyase activity
CO204_RS05130	COG0406	alpha-ribazole phosphatase activity
CO204_RS05140	COG2723	6-phospho-beta-galactosidase activity
CO204_RS05145	COG0628	permease
CO204_RS05150	COG1063	alcohol dehydrogenase
CO204_RS05165	COG1174	glycine betaine transport
CO204_RS05170	COG1136	(ABC) transporter
CO204_RS05175	COG0577	efflux transmembrane transporter activity
CO204_RS05185	COG3976	FMN-binding domain protein
CO204_RS05185	COG0431	NADPH-dependent FMN reductase
CO204_RS05185	COG1053	succinate dehydrogenase
CO204_RS05200	COG1942	4-Oxalocrotonate Tautomerase
CO204_RS05205	COG1435	thymidine kinase activity
CO204_RS05210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CO204_RS05215	COG2890	protein-(glutamine-N5) methyltransferase activity
CO204_RS05220	COG0009	L-threonylcarbamoyladenylate synthase
CO204_RS05225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO204_RS05240	COG1132	(ABC) transporter
CO204_RS05245	COG1132	(ABC) transporter
CO204_RS05250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO204_RS05255	COG4684	Psort location CytoplasmicMembrane, score
CO204_RS05260	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO204_RS05270	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO204_RS05275	COG1247	-acetyltransferase
CO204_RS05295	COG1131	(ABC) transporter
CO204_RS05305	COG0519	Catalyzes the synthesis of GMP from XMP
CO204_RS05310	COG2188	Transcriptional regulator
CO204_RS05320	COG4175	Glycine betaine
CO204_RS05320	COG3448	diguanylate cyclase activity
CO204_RS05330	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CO204_RS05335	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO204_RS05365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CO204_RS05370	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CO204_RS05380	COG1104	cysteine desulfurase activity
CO204_RS05385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO204_RS05390	COG4116	CYTH
CO204_RS05405	COG2357	RelA SpoT domain protein
CO204_RS05410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CO204_RS05415	COG0564	pseudouridine synthase activity
CO204_RS05420	COG0280	phosphate acetyltransferase
CO204_RS05430	COG1131	(ABC) transporter
CO204_RS05435	COG4221	oxidoreductase activity
CO204_RS05440	COG1442	glycosyl transferase family 8
CO204_RS05445	COG0745	RESPONSE REGULATOR receiver
CO204_RS05450	COG5002	protein histidine kinase activity
CO204_RS05460	COG1131	(ABC) transporter
CO204_RS05465	COG4974	Belongs to the 'phage' integrase family
CO204_RS05470	COG2801	Transposase and inactivated derivatives
CO204_RS05495	COG3052	prosthetic group binding
CO204_RS05500	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CO204_RS05505	COG0511	ligase activity, forming carbon-carbon bonds
CO204_RS05515	COG2851	Citrate transporter
CO204_RS05525	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CO204_RS05530	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CO204_RS05535	COG0642	Histidine kinase
CO204_RS05540	COG0745	RESPONSE REGULATOR receiver
CO204_RS05550	COG1136	(ABC) transporter
CO204_RS05555	COG0366	Alpha amylase catalytic
CO204_RS05555	COG5263	repeat protein
CO204_RS05560	COG0366	Alpha amylase catalytic
CO204_RS05560	COG5263	repeat protein
CO204_RS05565	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CO204_RS05570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO204_RS05575	COG0758	DNA mediated transformation
CO204_RS05590	COG4607	ABC-type enterochelin transport system periplasmic component
CO204_RS05595	COG4604	ABC transporter, ATP-binding protein
CO204_RS05600	COG4605	iron ion homeostasis
CO204_RS05605	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO204_RS05610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO204_RS05615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO204_RS05630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO204_RS05635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO204_RS05645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO204_RS05650	COG4932	domain protein
CO204_RS05680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO204_RS05680	COG2190	(PTS) system
CO204_RS05680	COG1263	PTS System
CO204_RS05685	COG3711	transcriptional antiterminator
CO204_RS05695	COG1177	transmembrane transport
CO204_RS05700	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO204_RS05705	COG3842	ATPase activity
CO204_RS05710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CO204_RS05730	COG0302	gtp cyclohydrolase
CO204_RS05735	COG0285	dihydrofolate synthase activity
CO204_RS05740	COG0083	homoserine kinase activity
CO204_RS05750	COG0726	polysaccharide deacetylase
CO204_RS05755	COG1960	acyl-CoA dehydrogenase activity
CO204_RS05765	COG0222	ribosome binding
CO204_RS05770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO204_RS05795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO204_RS05800	COG2040	homocysteine
CO204_RS05805	COG0833	amino acid
CO204_RS05810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CO204_RS05815	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CO204_RS05825	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CO204_RS05830	COG3201	nicotinamide mononucleotide transporter
CO204_RS05835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CO204_RS05840	COG3425	synthase
CO204_RS05855	COG1272	protein, Hemolysin III
CO204_RS05860	COG1304	FMN binding
CO204_RS05875	COG1126	abc transporter atp-binding protein
CO204_RS05880	COG0765	amino acid transport
CO204_RS05885	COG0765	amino acid transport
CO204_RS05890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO204_RS05900	COG0583	DNA-binding transcription factor activity
CO204_RS05905	COG3759	membrane
CO204_RS05915	COG0745	RESPONSE REGULATOR receiver
CO204_RS05920	COG2357	RelA SpoT domain protein
CO204_RS05930	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CO204_RS05935	COG1132	(ABC) transporter
CO204_RS05950	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CO204_RS05960	COG0602	queuosine metabolic process
CO204_RS05965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CO204_RS05975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CO204_RS05985	COG0366	Alpha amylase catalytic
CO204_RS05985	COG5263	repeat protein
CO204_RS05995	COG1132	(ABC) transporter
CO204_RS06005	COG0488	(ABC) transporter
CO204_RS06010	COG0617	tRNA 3'-terminal CCA addition
CO204_RS06015	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CO204_RS06020	COG1307	EDD domain protein, DegV family
CO204_RS06035	COG1131	(ABC) transporter
CO204_RS06055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO204_RS06060	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CO204_RS06065	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO204_RS06070	COG1609	Transcriptional regulator
CO204_RS06075	COG0366	Alpha amylase catalytic
CO204_RS06080	COG3842	ATPase activity
CO204_RS06085	COG0366	Alpha amylase catalytic
CO204_RS06090	COG0395	ABC-type sugar transport system, permease component
CO204_RS06095	COG1175	transmembrane transport
CO204_RS06100	COG1653	transport
CO204_RS06105	COG3345	alpha-galactosidase
CO204_RS06110	COG2207	Transcriptional regulator
CO204_RS06125	COG0646	methionine synthase
CO204_RS06125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CO204_RS06130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO204_RS06135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO204_RS06135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO204_RS06135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO204_RS06140	COG1105	Belongs to the carbohydrate kinase PfkB family
CO204_RS06145	COG1349	DNA-binding transcription factor activity
CO204_RS06150	COG0492	ferredoxin-NADP+ reductase activity
CO204_RS06155	COG0336	Belongs to the RNA methyltransferase TrmD family
CO204_RS06160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CO204_RS06165	COG1837	Belongs to the UPF0109 family
CO204_RS06170	COG0228	four-way junction DNA binding
CO204_RS06175	COG0577	efflux transmembrane transporter activity
CO204_RS06180	COG1136	(ABC) transporter
CO204_RS06190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO204_RS06235	COG0505	Belongs to the CarA family
CO204_RS06240	COG0540	Belongs to the ATCase OTCase family
CO204_RS06250	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CO204_RS06260	COG0564	pseudouridine synthase activity
CO204_RS06265	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CO204_RS06270	COG0583	DNA-binding transcription factor activity
CO204_RS06275	COG2816	NAD+ diphosphatase activity
CO204_RS06285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CO204_RS06295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CO204_RS06315	COG0301	tRNA thio-modification
CO204_RS06320	COG1104	cysteine desulfurase activity
CO204_RS06330	COG0285	dihydrofolate synthase activity
CO204_RS06335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO204_RS06340	COG0656	L-ascorbic acid biosynthetic process
CO204_RS06345	COG3942	CHAP domain
CO204_RS06365	COG1368	sulfuric ester hydrolase activity
CO204_RS06400	COG1091	dTDP-4-dehydrorhamnose reductase activity
CO204_RS06405	COG2151	metal-sulfur cluster biosynthetic enzyme
CO204_RS06410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO204_RS06415	COG0358	DNA primase activity
CO204_RS06425	COG1970	mechanosensitive ion channel activity
CO204_RS06435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO204_RS06445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO204_RS06475	COG0556	nucleotide-excision repair
CO204_RS06490	COG1126	abc transporter atp-binding protein
CO204_RS06495	COG0488	(ABC) transporter
CO204_RS06505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO204_RS06565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO204_RS06575	COG0077	Prephenate dehydratase
CO204_RS06580	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CO204_RS06585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CO204_RS06590	COG3679	Belongs to the UPF0342 family
CO204_RS06595	COG0287	Prephenate dehydrogenase
CO204_RS06600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CO204_RS06605	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CO204_RS06610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO204_RS06615	COG0710	3-dehydroquinate dehydratase activity
CO204_RS06620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CO204_RS06625	COG1368	sulfuric ester hydrolase activity
CO204_RS06635	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CO204_RS06640	COG0366	Alpha amylase catalytic
CO204_RS06640	COG5263	repeat protein
CO204_RS06650	COG1914	H( )-stimulated, divalent metal cation uptake system
CO204_RS06655	COG4443	Transcriptional Coactivator p15 (PC4)
CO204_RS06670	COG0450	alkyl hydroperoxide reductase
CO204_RS06675	COG0826	peptidase U32
CO204_RS06700	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CO204_RS06705	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CO204_RS06715	COG3091	SprT-like family
CO204_RS06720	COG2183	response to ionizing radiation
CO204_RS06735	COG0701	Predicted permease
CO204_RS06740	COG3689	TIGRFAM TIGR03943 family protein
CO204_RS06745	COG0477	Major facilitator Superfamily
CO204_RS06750	COG0552	protein localization to endoplasmic reticulum
CO204_RS06755	COG0561	phosphatase activity
CO204_RS06760	COG0561	phosphatase activity
CO204_RS06810	COG1131	(ABC) transporter
CO204_RS06820	COG0604	alcohol dehydrogenase
CO204_RS06835	COG0584	glycerophosphoryl diester phosphodiesterase
CO204_RS06860	COG1078	dGTPase activity
CO204_RS06870	COG2348	transferase activity, transferring amino-acyl groups
CO204_RS06880	COG0149	triose-phosphate isomerase activity
CO204_RS06885	COG2274	protein secretion by the type I secretion system
CO204_RS06915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO204_RS06920	COG0772	Belongs to the SEDS family
CO204_RS06930	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CO204_RS06950	COG3859	Proton-coupled thiamine transporter YuaJ
CO204_RS06965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CO204_RS06975	COG0588	phosphoglycerate mutase activity
CO204_RS06980	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO204_RS06985	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO204_RS06990	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CO204_RS06995	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CO204_RS07015	COG2195	Cleaves the N-terminal amino acid of tripeptides
CO204_RS07040	COG0656	L-ascorbic acid biosynthetic process
CO204_RS07045	COG0656	L-ascorbic acid biosynthetic process
CO204_RS07050	COG0789	Transcriptional regulator
CO204_RS07055	COG1012	belongs to the aldehyde dehydrogenase family
CO204_RS07060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO204_RS07065	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO204_RS07080	COG0538	isocitrate dehydrogenase activity
CO204_RS07085	COG0372	Belongs to the citrate synthase family
CO204_RS07090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CO204_RS07095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CO204_RS07100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO204_RS07110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CO204_RS07115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CO204_RS07120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CO204_RS07125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CO204_RS07160	COG1136	(ABC) transporter
CO204_RS07175	COG1131	(ABC) transporter
CO204_RS07180	COG1132	(ABC) transporter
CO204_RS07215	COG1396	sequence-specific DNA binding
CO204_RS07220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO204_RS07230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO204_RS07235	COG4122	O-methyltransferase activity
CO204_RS07240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CO204_RS07240	COG0131	Imidazoleglycerol-phosphate dehydratase
CO204_RS07270	COG0604	alcohol dehydrogenase
CO204_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
CO204_RS07270	COG3321	synthase
CO204_RS07275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO204_RS07285	COG1187	pseudouridine synthase activity
CO204_RS07295	COG0363	glucosamine-6-phosphate deaminase activity
CO204_RS07305	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CO204_RS07330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CO204_RS07345	COG0658	competence protein
CO204_RS07345	COG2333	competence protein COMEC
CO204_RS07350	COG1596	polysaccharide export
CO204_RS07350	COG1555	photosystem II stabilization
CO204_RS07355	COG0204	Acyl-transferase
CO204_RS07360	COG0726	polysaccharide deacetylase
CO204_RS07370	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CO204_RS07390	COG0513	Belongs to the DEAD box helicase family
CO204_RS07395	COG3064	Membrane
CO204_RS07395	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CO204_RS07405	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CO204_RS07425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO204_RS07430	COG0385	Bile acid
CO204_RS07440	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO204_RS07445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CO204_RS07450	COG0768	penicillin binding
CO204_RS07455	COG0588	phosphoglycerate mutase activity
CO204_RS07470	COG0735	belongs to the Fur family
CO204_RS07485	COG2801	Transposase and inactivated derivatives
CO204_RS07490	COG0776	regulation of translation
CO204_RS07500	COG2755	lipolytic protein G-D-S-L family
CO204_RS07505	COG1307	EDD domain protein, DegV family
CO204_RS07510	COG0497	DNA recombination
CO204_RS07515	COG1438	arginine binding
CO204_RS07520	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CO204_RS07530	COG1722	exodeoxyribonuclease VII activity
CO204_RS07535	COG1570	exodeoxyribonuclease VII activity
CO204_RS07540	COG3275	phosphorelay sensor kinase activity
CO204_RS07545	COG3279	Response regulator of the LytR AlgR family
CO204_RS07550	COG1380	Effector of murein hydrolase LrgA
CO204_RS07555	COG1346	cytolysis
CO204_RS07560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CO204_RS07565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO204_RS07585	COG1126	abc transporter atp-binding protein
CO204_RS07590	COG0765	amino acid transport
CO204_RS07595	COG4703	Protein of unknown function (DUF1797)
CO204_RS07600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CO204_RS07605	COG0542	response to heat
CO204_RS07620	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO204_RS07625	COG3599	regulation of cell shape
CO204_RS07630	COG2302	S4 RNA-binding domain
CO204_RS07640	COG1799	cell septum assembly
CO204_RS07645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CO204_RS07655	COG0849	cell division
CO204_RS07665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CO204_RS07670	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CO204_RS07680	COG1217	gtp-binding protein TYPA
CO204_RS07690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO204_RS07695	COG1940	carbohydrate kinase activity
CO204_RS07705	COG0783	Belongs to the Dps family
CO204_RS07715	COG0159	tryptophan synthase activity
CO204_RS07720	COG0133	tryptophan synthase activity
CO204_RS07725	COG0135	phosphoribosylanthranilate isomerase activity
CO204_RS07730	COG0134	indole-3-glycerol-phosphate synthase activity
CO204_RS07735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CO204_RS07740	COG0512	Glutamine amidotransferase of anthranilate synthase
CO204_RS07745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CO204_RS07765	COG3804	dihydrodipicolinate reductase
CO204_RS07775	COG1132	(ABC) transporter
CO204_RS07780	COG1132	(ABC) transporter
CO204_RS07790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CO204_RS07795	COG4470	Protein conserved in bacteria
CO204_RS07800	COG0737	Belongs to the 5'-nucleotidase family
CO204_RS07805	COG3480	Lon protease (S16) C-terminal proteolytic domain
CO204_RS07810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CO204_RS07815	COG0742	ribosomal rna small subunit methyltransferase
CO204_RS07820	COG4716	Myosin-crossreactive antigen
CO204_RS07875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO204_RS07885	COG0561	phosphatase activity
CO204_RS07890	COG1349	DNA-binding transcription factor activity
CO204_RS07935	COG1040	competence protein
CO204_RS07940	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CO204_RS07945	COG1739	Uncharacterized protein family UPF0029
CO204_RS07965	COG1882	Formate acetyltransferase
CO204_RS07970	COG1349	DNA-binding transcription factor activity
CO204_RS07975	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CO204_RS07980	COG1098	S1 RNA binding domain
CO204_RS07990	COG2197	response regulator
CO204_RS07995	COG4585	Histidine kinase
CO204_RS08015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO204_RS08015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO204_RS08020	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO204_RS08025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CO204_RS08030	COG1758	RNA polymerase activity
CO204_RS08035	COG0194	GDP metabolic process
CO204_RS08040	COG4372	Transposase
CO204_RS08040	COG1418	mRNA catabolic process
CO204_RS08045	COG1854	S-ribosylhomocysteine lyase activity
CO204_RS08055	COG0116	Belongs to the methyltransferase superfamily
CO204_RS08065	COG3599	regulation of cell shape
CO204_RS08070	COG4474	Belongs to the UPF0398 family
CO204_RS08075	COG3331	DNA recombination
CO204_RS08080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO204_RS08085	COG3579	cysteine-type endopeptidase activity
CO204_RS08090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CO204_RS08095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO204_RS08100	COG0492	ferredoxin-NADP+ reductase activity
CO204_RS08110	COG1126	abc transporter atp-binding protein
CO204_RS08125	COG0513	Belongs to the DEAD box helicase family
CO204_RS08135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO204_RS08140	COG0768	penicillin binding
CO204_RS08145	COG4839	cell division protein FtsL
CO204_RS08150	COG0275	rRNA processing
CO204_RS08160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CO204_RS08165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CO204_RS08175	COG4224	UPF0291 protein
CO204_RS08180	COG0751	glycine-tRNA ligase activity
CO204_RS08185	COG0752	glycyl-tRNA synthetase alpha subunit
CO204_RS08195	COG1673	EVE domain
CO204_RS08215	COG1924	4 iron, 4 sulfur cluster binding
CO204_RS08270	COG1131	(ABC) transporter
CO204_RS08280	COG0561	phosphatase activity
CO204_RS08290	COG2217	Heavy metal translocating P-type atpase
CO204_RS08305	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CO204_RS08310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CO204_RS08320	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CO204_RS08325	COG0195	Participates in both transcription termination and antitermination
CO204_RS08330	COG0779	Required for maturation of 30S ribosomal subunits
CO204_RS08340	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO204_RS08350	COG4473	ABC transporter
CO204_RS08355	COG1131	(ABC) transporter
CO204_RS08360	COG0537	adenosine 5'-monophosphoramidase activity
CO204_RS08370	COG1316	TRANSCRIPTIONal
CO204_RS08375	COG0802	atpase or kinase
CO204_RS08380	COG2252	PERMEase
CO204_RS08390	COG0561	phosphatase activity
CO204_RS08405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO204_RS08410	COG1882	Formate acetyltransferase
CO204_RS08425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO204_RS08440	COG2936	dipeptidyl-peptidase activity
CO204_RS08470	COG0582	viral genome integration into host DNA
CO204_RS08475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CO204_RS08485	COG2081	HI0933 family
CO204_RS08505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CO204_RS08515	COG1214	PFAM Peptidase M22, glycoprotease
CO204_RS08525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CO204_RS08535	COG0667	Aldo Keto reductase
CO204_RS08555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CO204_RS08570	COG2226	methyltransferase
CO204_RS08590	COG5503	Protein of unknown function (DUF1447)
CO204_RS08600	COG3942	CHAP domain
CO204_RS08605	COG0493	'glutamate synthase
CO204_RS08610	COG0069	glutamate synthase activity
CO204_RS08610	COG0070	glutamate synthase
CO204_RS08610	COG0067	glutamate synthase
CO204_RS08615	COG0174	glutamine synthetase
CO204_RS08620	COG0789	Transcriptional regulator
CO204_RS08630	COG0126	phosphoglycerate kinase activity
CO204_RS08640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO204_RS08645	COG0049	tRNA binding
CO204_RS08650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CO204_RS08660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO204_RS08685	COG1162	GTPase activity
CO204_RS08705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO204_RS08725	COG0084	hydrolase, TatD family'
CO204_RS08730	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CO204_RS08745	COG0706	membrane insertase activity
CO204_RS08750	COG0594	ribonuclease P activity
CO204_RS08755	COG0165	Argininosuccinate lyase
CO204_RS08760	COG0137	argininosuccinate synthase activity
CO204_RS08795	COG1827	regulation of RNA biosynthetic process
CO204_RS08800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CO204_RS08825	COG0756	dUTP diphosphatase activity
CO204_RS08830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO204_RS08835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CO204_RS08840	COG0457	Tetratricopeptide repeat
CO204_RS08840	COG0705	Rhomboid family
CO204_RS08845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CO204_RS08850	COG1473	amidohydrolase
CO204_RS08855	COG2171	N-acyltransferase activity
CO204_RS08895	COG3732	PTS system glucitol sorbitol-specific
CO204_RS08900	COG3730	PTS system glucitol sorbitol-specific
CO204_RS08910	COG3711	transcriptional antiterminator
CO204_RS08910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO204_RS08920	COG0166	Belongs to the GPI family
CO204_RS08935	COG1028	Short-chain dehydrogenase reductase Sdr
CO204_RS08940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO204_RS08960	COG1136	(ABC) transporter
CO204_RS08980	COG1131	(ABC) transporter
CO204_RS08990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO204_RS09030	COG1234	tRNA 3'-trailer cleavage
CO204_RS09045	COG0343	queuine tRNA-ribosyltransferase activity
CO204_RS09055	COG1832	CoA-binding protein
CO204_RS09060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO204_RS09060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO204_RS09090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CO204_RS09135	COG2274	protein secretion by the type I secretion system
CO204_RS09195	COG3623	hexulose-6-phosphate isomerase
CO204_RS09205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO204_RS09220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CO204_RS09225	COG2918	glutathione biosynthetic process
CO204_RS09225	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO204_RS09235	COG2957	Belongs to the agmatine deiminase family
CO204_RS09240	COG0531	amino acid
CO204_RS09245	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CO204_RS09260	COG4608	Belongs to the ABC transporter superfamily
CO204_RS09265	COG0444	Belongs to the ABC transporter superfamily
CO204_RS09270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO204_RS09275	COG0601	transmembrane transport
CO204_RS09280	COG4166	transmembrane transport
CO204_RS09295	COG0719	Fe-S assembly protein
CO204_RS09305	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CO204_RS09310	COG0719	Fe-S assembly protein
CO204_RS09320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO204_RS09325	COG4862	establishment of competence for transformation
CO204_RS09330	COG1968	undecaprenyl-diphosphatase activity
CO204_RS09340	COG0765	amino acid transport
CO204_RS09345	COG1126	abc transporter atp-binding protein
CO204_RS09355	COG1131	(ABC) transporter
CO204_RS09365	COG1309	transcriptional regulator
CO204_RS09375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CO204_RS09380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CO204_RS09385	COG0440	acetolactate synthase activity
CO204_RS09390	COG0028	Belongs to the TPP enzyme family
CO204_RS09395	COG1461	Dihydroxyacetone kinase
CO204_RS09530	COG0203	ribosomal protein L17
CO204_RS09535	COG0202	RNA polymerase activity
CO204_RS09540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO204_RS09545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO204_RS09555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CO204_RS09560	COG0563	adenylate kinase activity
CO204_RS09565	COG0201	protein transport
CO204_RS09570	COG0200	Binds to the 23S rRNA
CO204_RS09575	COG1841	ribosomal large subunit assembly
CO204_RS09580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO204_RS09590	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CO204_RS09595	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CO204_RS09600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO204_RS09605	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO204_RS09610	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CO204_RS09615	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CO204_RS09620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CO204_RS09625	COG0255	Belongs to the universal ribosomal protein uL29 family
CO204_RS09630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CO204_RS09635	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CO204_RS09640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CO204_RS09650	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO204_RS09655	COG0089	rRNA binding
CO204_RS09665	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CO204_RS09670	COG0051	transcription antitermination factor activity, RNA binding
CO204_RS09680	COG1621	beta-fructofuranosidase activity
CO204_RS09685	COG0542	response to heat
CO204_RS09690	COG4463	regulation of RNA biosynthetic process
CO204_RS09695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CO204_RS09700	COG0052	Belongs to the universal ribosomal protein uS2 family
CO204_RS09715	COG1619	proteins homologs of microcin C7 resistance protein MccF
CO204_RS09720	COG3590	peptidase
CO204_RS09760	COG0492	ferredoxin-NADP+ reductase activity
CO204_RS09770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO204_RS09790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO204_RS09795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CO204_RS09820	COG1396	sequence-specific DNA binding
CO204_RS09860	COG0366	Alpha amylase catalytic
CO204_RS09865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO204_RS09865	COG1263	PTS System
CO204_RS09870	COG2188	Transcriptional regulator
CO204_RS09875	COG5297	Belongs to the glycosyl hydrolase family 6
CO204_RS09880	COG1490	D-aminoacyl-tRNA deacylase activity
CO204_RS09895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO204_RS09895	COG2190	(PTS) system
CO204_RS09895	COG1263	PTS System
CO204_RS09910	COG1609	Transcriptional regulator
CO204_RS09915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CO204_RS09920	COG2264	protein methyltransferase activity
CO204_RS09940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO204_RS09955	COG2217	Heavy metal translocating P-type atpase
CO204_RS09965	COG2855	membrane
CO204_RS09970	COG0583	DNA-binding transcription factor activity
CO204_RS09980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CO204_RS09990	COG3942	CHAP domain
CO204_RS09990	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO204_RS10105	COG4499	WXG100 protein secretion system (Wss), protein YukC
CO204_RS10130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO204_RS10140	COG0463	Glycosyl transferase, family 2
CO204_RS10200	COG3906	Belongs to the UPF0473 family
CO204_RS10205	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CO204_RS10210	COG4472	Bacterial protein of unknown function (DUF965)
CO204_RS10235	COG1393	Belongs to the ArsC family
CO204_RS10240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CO204_RS10245	COG1058	Belongs to the CinA family
CO204_RS10245	COG1546	Belongs to the CinA family
CO204_RS10250	COG0519	Catalyzes the synthesis of GMP from XMP
CO204_RS10255	COG0632	four-way junction helicase activity
CO204_RS10260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CO204_RS10270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO204_RS10280	COG1438	arginine binding
CO204_RS10300	COG0018	arginyl-trna synthetase
CO204_RS10305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO204_RS10310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO204_RS10315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO204_RS10320	COG0124	histidyl-tRNA synthetase
CO204_RS10325	COG0531	amino acid
CO204_RS10330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CO204_RS10335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO204_RS10355	COG0640	Transcriptional regulator
CO204_RS10360	COG2814	Major facilitator Superfamily
CO204_RS10380	COG0789	Transcriptional regulator
CO204_RS10385	COG1028	Short-chain dehydrogenase reductase Sdr
CO204_RS10410	COG2094	Belongs to the DNA glycosylase MPG family
CO204_RS10430	COG1012	belongs to the aldehyde dehydrogenase family
CO204_RS10435	COG0129	dihydroxy-acid dehydratase activity
CO204_RS10440	COG2151	metal-sulfur cluster biosynthetic enzyme
CO204_RS10465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CO204_RS10480	COG0305	Participates in initiation and elongation during chromosome replication
CO204_RS10485	COG0359	binds to the 23S rRNA
CO204_RS10495	COG0445	tRNA wobble uridine modification
CO204_RS10505	COG0482	sulfurtransferase activity
CO204_RS10510	COG0741	lytic transglycosylase activity
CO204_RS10520	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CO204_RS10525	COG1122	ATPase activity
CO204_RS10530	COG1122	ATPase activity
CO204_RS10535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CO204_RS10545	COG0612	Peptidase, M16
CO204_RS10560	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO204_RS10565	COG0517	IMP dehydrogenase activity
CO204_RS10565	COG0516	GMP reductase activity
CO204_RS10570	COG0180	Tryptophanyl-tRNA synthetase
CO204_RS10575	COG0488	(ABC) transporter
CO204_RS10605	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CO204_RS10610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO204_RS10615	COG1475	DNA binding