locus-tag	class	description
SMULJ23_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SMULJ23_RS00010	COG0592	DNA-directed DNA polymerase activity
SMULJ23_RS00020	COG0012	GTP binding
SMULJ23_RS00025	COG0193	aminoacyl-tRNA hydrolase activity
SMULJ23_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMULJ23_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SMULJ23_RS00055	COG0037	tRNA processing
SMULJ23_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SMULJ23_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMULJ23_RS00070	COG0531	amino acid
SMULJ23_RS00180	COG1792	Involved in formation and maintenance of cell shape
SMULJ23_RS00190	COG3942	CHAP domain
SMULJ23_RS00195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMULJ23_RS00200	COG0436	Aminotransferase
SMULJ23_RS00205	COG1381	Involved in DNA repair and RecF pathway recombination
SMULJ23_RS00210	COG0416	fatty acid biosynthetic process
SMULJ23_RS00215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMULJ23_RS00220	COG2274	protein secretion by the type I secretion system
SMULJ23_RS00225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SMULJ23_RS00230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SMULJ23_RS00240	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SMULJ23_RS00250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SMULJ23_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
SMULJ23_RS00260	COG0138	bifunctional purine biosynthesis protein purh
SMULJ23_RS00310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SMULJ23_RS00325	COG1794	racemase activity, acting on amino acids and derivatives
SMULJ23_RS00345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SMULJ23_RS00365	COG2255	four-way junction helicase activity
SMULJ23_RS00370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SMULJ23_RS00390	COG0534	Mate efflux family protein
SMULJ23_RS00395	COG3830	Belongs to the UPF0237 family
SMULJ23_RS00400	COG2848	UPF0210 protein
SMULJ23_RS00415	COG1705	Flagellar rod assembly protein muramidase FlgJ
SMULJ23_RS00420	COG5492	domain, Protein
SMULJ23_RS00420	COG3583	domain protein
SMULJ23_RS00420	COG1621	beta-fructofuranosidase activity
SMULJ23_RS00430	COG1420	regulation of RNA biosynthetic process
SMULJ23_RS00435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SMULJ23_RS00445	COG0443	Heat shock 70 kDa protein
SMULJ23_RS00450	COG0484	heat shock protein binding
SMULJ23_RS00455	COG0101	tRNA pseudouridine synthase activity
SMULJ23_RS00460	COG0351	phosphomethylpyrimidine kinase
SMULJ23_RS00465	COG4720	Psort location CytoplasmicMembrane, score
SMULJ23_RS00470	COG4475	Protein of unknown function (DUF436)
SMULJ23_RS00475	COG0668	transmembrane transport
SMULJ23_RS00485	COG0544	peptidyl-prolyl cis-trans isomerase activity
SMULJ23_RS00495	COG3343	RNA polymerase activity
SMULJ23_RS00500	COG0504	CTP synthase activity
SMULJ23_RS00510	COG0191	fructose-bisphosphate aldolase activity
SMULJ23_RS00520	COG3715	PTS system
SMULJ23_RS00560	COG1396	sequence-specific DNA binding
SMULJ23_RS00570	COG1105	Belongs to the carbohydrate kinase PfkB family
SMULJ23_RS00575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMULJ23_RS00575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMULJ23_RS00575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMULJ23_RS00580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMULJ23_RS00580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMULJ23_RS00580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMULJ23_RS00585	COG3684	Belongs to the aldolase LacD family
SMULJ23_RS00600	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SMULJ23_RS00605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SMULJ23_RS00610	COG0534	Mate efflux family protein
SMULJ23_RS00615	COG2176	DNA-directed DNA polymerase activity
SMULJ23_RS00620	COG1846	Transcriptional regulator
SMULJ23_RS00625	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SMULJ23_RS00630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMULJ23_RS00635	COG0022	dehydrogenase e1 component
SMULJ23_RS00635	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMULJ23_RS00650	COG0095	Lipoate-protein ligase
SMULJ23_RS00655	COG1473	amidohydrolase
SMULJ23_RS00660	COG0477	Major facilitator Superfamily
SMULJ23_RS00665	COG1309	transcriptional regulator
SMULJ23_RS00670	COG0583	DNA-binding transcription factor activity
SMULJ23_RS00680	COG0281	malic enzyme
SMULJ23_RS00685	COG0679	Auxin Efflux Carrier
SMULJ23_RS00690	COG2140	Oxalate decarboxylase
SMULJ23_RS00705	COG0242	peptide deformylase activity
SMULJ23_RS00710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMULJ23_RS00720	COG1012	belongs to the aldehyde dehydrogenase family
SMULJ23_RS00720	COG1454	alcohol dehydrogenase
SMULJ23_RS00725	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMULJ23_RS00730	COG1185	polyribonucleotide nucleotidyltransferase activity
SMULJ23_RS00740	COG1045	serine acetyltransferase
SMULJ23_RS00745	COG0215	cysteine-tRNA ligase activity
SMULJ23_RS00750	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SMULJ23_RS00755	COG5504	Zn-dependent protease
SMULJ23_RS00775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMULJ23_RS00795	COG1476	TRANSCRIPTIONal
SMULJ23_RS00800	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SMULJ23_RS00805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMULJ23_RS00825	COG0492	ferredoxin-NADP+ reductase activity
SMULJ23_RS00835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMULJ23_RS00890	COG1028	Short-chain dehydrogenase reductase Sdr
SMULJ23_RS00890	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMULJ23_RS00890	COG4221	oxidoreductase activity
SMULJ23_RS00890	COG3321	synthase
SMULJ23_RS00895	COG1122	ATPase activity
SMULJ23_RS00910	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
SMULJ23_RS00935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMULJ23_RS00945	COG3976	FMN-binding domain protein
SMULJ23_RS00945	COG1053	succinate dehydrogenase
SMULJ23_RS00945	COG0431	NADPH-dependent FMN reductase
SMULJ23_RS00950	COG0431	NADPH-dependent FMN reductase
SMULJ23_RS00950	COG1053	succinate dehydrogenase
SMULJ23_RS00950	COG3976	FMN-binding domain protein
SMULJ23_RS00955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMULJ23_RS00970	COG0803	Belongs to the bacterial solute-binding protein 9 family
SMULJ23_RS00980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SMULJ23_RS00985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SMULJ23_RS01020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SMULJ23_RS01030	COG1121	(ABC) transporter
SMULJ23_RS01035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SMULJ23_RS01040	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SMULJ23_RS01045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMULJ23_RS01050	COG0085	RNA polymerase activity
SMULJ23_RS01055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMULJ23_RS01065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SMULJ23_RS01070	COG1459	type II secretion system
SMULJ23_RS01100	COG0827	DNA restriction-modification system
SMULJ23_RS01105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SMULJ23_RS01130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SMULJ23_RS01135	COG1363	Peptidase, m42
SMULJ23_RS01145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMULJ23_RS01150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMULJ23_RS01155	COG1846	Transcriptional regulator
SMULJ23_RS01175	COG4585	Histidine kinase
SMULJ23_RS01180	COG2197	response regulator
SMULJ23_RS01200	COG3715	PTS system
SMULJ23_RS01205	COG3716	PTS system mannose fructose sorbose family IID component
SMULJ23_RS01215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SMULJ23_RS01220	COG0459	protein refolding
SMULJ23_RS01230	COG0564	pseudouridine synthase activity
SMULJ23_RS01235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMULJ23_RS01265	COG0495	leucyl-tRNA aminoacylation
SMULJ23_RS01270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMULJ23_RS01275	COG1464	Belongs to the NlpA lipoprotein family
SMULJ23_RS01280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMULJ23_RS01285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SMULJ23_RS01295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SMULJ23_RS01305	COG4720	Psort location CytoplasmicMembrane, score
SMULJ23_RS01310	COG1122	ATPase activity
SMULJ23_RS01320	COG0357	Ribosomal RNA small subunit methyltransferase G
SMULJ23_RS01325	COG1704	LemA family
SMULJ23_RS01330	COG0501	Belongs to the peptidase M48B family
SMULJ23_RS01335	COG4591	ABC-type transport system involved in lipoprotein release permease component
SMULJ23_RS01340	COG1136	(ABC) transporter
SMULJ23_RS01355	COG0745	RESPONSE REGULATOR receiver
SMULJ23_RS01360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SMULJ23_RS01370	COG1484	DNA-dependent DNA replication
SMULJ23_RS01375	COG1160	GTP binding
SMULJ23_RS01385	COG0586	Pfam SNARE associated Golgi protein
SMULJ23_RS01395	COG3290	protein histidine kinase activity
SMULJ23_RS01470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMULJ23_RS01480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMULJ23_RS01495	COG3716	PTS system mannose fructose sorbose family IID component
SMULJ23_RS01500	COG3715	PTS system
SMULJ23_RS01515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SMULJ23_RS01520	COG0681	Belongs to the peptidase S26 family
SMULJ23_RS01525	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMULJ23_RS01540	COG1193	negative regulation of DNA recombination
SMULJ23_RS01545	COG3118	belongs to the thioredoxin family
SMULJ23_RS01550	COG1063	alcohol dehydrogenase
SMULJ23_RS01555	COG1194	a g-specific adenine glycosylase
SMULJ23_RS01565	COG0360	Binds together with S18 to 16S ribosomal RNA
SMULJ23_RS01570	COG0629	single-stranded DNA binding
SMULJ23_RS01575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SMULJ23_RS01615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SMULJ23_RS01620	COG0006	proline dipeptidase activity
SMULJ23_RS01625	COG2131	deaminase
SMULJ23_RS01630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SMULJ23_RS01635	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMULJ23_RS01645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMULJ23_RS01650	COG1609	Transcriptional regulator
SMULJ23_RS01655	COG1621	beta-fructofuranosidase activity
SMULJ23_RS01660	COG2190	(PTS) system
SMULJ23_RS01660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMULJ23_RS01660	COG1263	PTS System
SMULJ23_RS01665	COG1940	carbohydrate kinase activity
SMULJ23_RS01670	COG1482	cell wall glycoprotein biosynthetic process
SMULJ23_RS01675	COG0653	protein targeting
SMULJ23_RS01680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMULJ23_RS01685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
SMULJ23_RS01690	COG0736	holo-[acyl-carrier-protein] synthase activity
SMULJ23_RS01695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SMULJ23_RS01700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SMULJ23_RS01710	COG0252	asparaginase activity
SMULJ23_RS01715	COG0561	phosphatase activity
SMULJ23_RS01725	COG1268	BioY protein
SMULJ23_RS01730	COG0436	Aminotransferase
SMULJ23_RS01735	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SMULJ23_RS01740	COG1335	isochorismatase
SMULJ23_RS01745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMULJ23_RS01750	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMULJ23_RS01755	COG0154	amidase activity
SMULJ23_RS01760	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMULJ23_RS01770	COG1819	glycosyl
SMULJ23_RS01790	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SMULJ23_RS01795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMULJ23_RS01800	COG1534	Rna-binding protein
SMULJ23_RS01805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SMULJ23_RS01810	COG1713	HD superfamily hydrolase involved in NAD metabolism
SMULJ23_RS01815	COG0799	negative regulation of ribosome biogenesis
SMULJ23_RS01820	COG2226	methyltransferase
SMULJ23_RS01835	COG1323	Belongs to the UPF0348 family
SMULJ23_RS01840	COG0789	Transcriptional regulator
SMULJ23_RS01845	COG0217	transcriptional regulatory protein
SMULJ23_RS01855	COG1862	Preprotein translocase
SMULJ23_RS01860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMULJ23_RS01865	COG4589	Belongs to the CDS family
SMULJ23_RS01875	COG0442	prolyl-tRNA aminoacylation
SMULJ23_RS01930	COG3557	Belongs to the UPF0374 family
SMULJ23_RS01935	COG2137	regulation of response to DNA damage stimulus
SMULJ23_RS01940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMULJ23_RS01945	COG1780	Probably involved in ribonucleotide reductase function
SMULJ23_RS01980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SMULJ23_RS01990	COG0525	valine-tRNA ligase activity
SMULJ23_RS02035	COG1518	maintenance of DNA repeat elements
SMULJ23_RS02040	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMULJ23_RS02110	COG0527	aspartate kinase activity
SMULJ23_RS02115	COG0546	phosphoglycolate phosphatase activity
SMULJ23_RS02120	COG1024	Enoyl-CoA hydratase
SMULJ23_RS02125	COG1846	Transcriptional regulator
SMULJ23_RS02130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMULJ23_RS02145	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SMULJ23_RS02150	COG1028	Short-chain dehydrogenase reductase Sdr
SMULJ23_RS02155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SMULJ23_RS02165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SMULJ23_RS02170	COG0439	Biotin carboxylase
SMULJ23_RS02185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMULJ23_RS02195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SMULJ23_RS02205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SMULJ23_RS02210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SMULJ23_RS02215	COG0706	membrane insertase activity
SMULJ23_RS02220	COG1254	Belongs to the acylphosphatase family
SMULJ23_RS02225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SMULJ23_RS02240	COG0019	diaminopimelate decarboxylase activity
SMULJ23_RS02245	COG3763	UPF0154 protein
SMULJ23_RS02250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SMULJ23_RS02255	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMULJ23_RS02270	COG0582	viral genome integration into host DNA
SMULJ23_RS02275	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SMULJ23_RS02280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SMULJ23_RS02285	COG1187	pseudouridine synthase activity
SMULJ23_RS02290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SMULJ23_RS02295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMULJ23_RS02300	COG0569	domain protein
SMULJ23_RS02325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
SMULJ23_RS02330	COG0671	phosphoesterase, PA-phosphatase related
SMULJ23_RS02340	COG1346	cytolysis
SMULJ23_RS02345	COG1242	4 iron, 4 sulfur cluster binding
SMULJ23_RS02350	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SMULJ23_RS02355	COG1119	ATPase activity
SMULJ23_RS02360	COG0628	permease
SMULJ23_RS02365	COG1253	flavin adenine dinucleotide binding
SMULJ23_RS02370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMULJ23_RS02380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SMULJ23_RS02385	COG1696	Membrane protein involved in D-alanine export
SMULJ23_RS02390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SMULJ23_RS02395	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SMULJ23_RS02400	COG1227	inorganic diphosphatase activity
SMULJ23_RS02410	COG2378	regulation of single-species biofilm formation
SMULJ23_RS02415	COG0693	protein deglycase activity
SMULJ23_RS02440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SMULJ23_RS02445	COG2244	polysaccharide biosynthetic process
SMULJ23_RS02450	COG0626	cystathionine gamma-synthase activity
SMULJ23_RS02455	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SMULJ23_RS02460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMULJ23_RS02465	COG0740	serine-type endopeptidase activity
SMULJ23_RS02475	COG4471	UPF0298 protein
SMULJ23_RS02485	COG0559	Belongs to the binding-protein-dependent transport system permease family
SMULJ23_RS02505	COG0517	IMP dehydrogenase activity
SMULJ23_RS02510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMULJ23_RS02515	COG0470	DNA polymerase III
SMULJ23_RS02520	COG1774	PSP1 C-terminal conserved region
SMULJ23_RS02525	COG4467	Involved in initiation control of chromosome replication
SMULJ23_RS02535	COG0004	ammonium transporteR
SMULJ23_RS02540	COG0347	Belongs to the P(II) protein family
SMULJ23_RS02545	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SMULJ23_RS02555	COG0454	-acetyltransferase
SMULJ23_RS02560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SMULJ23_RS02565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SMULJ23_RS02570	COG1393	Belongs to the ArsC family
SMULJ23_RS02575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMULJ23_RS02580	COG0708	Exodeoxyribonuclease III
SMULJ23_RS02590	COG0640	Transcriptional regulator
SMULJ23_RS02625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMULJ23_RS02625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMULJ23_RS02640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SMULJ23_RS02665	COG1674	ftsk spoiiie
SMULJ23_RS02675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMULJ23_RS02680	COG0081	regulation of translation
SMULJ23_RS02685	COG0528	UMP kinase activity
SMULJ23_RS02690	COG0233	cytoplasmic translational termination
SMULJ23_RS02700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SMULJ23_RS02705	COG4479	Belongs to the UPF0346 family
SMULJ23_RS02710	COG1702	phosphate starvation-inducible protein PhoH
SMULJ23_RS02715	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SMULJ23_RS02720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SMULJ23_RS02725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SMULJ23_RS02740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SMULJ23_RS02745	COG0237	dephospho-CoA kinase activity
SMULJ23_RS02750	COG2814	Major facilitator Superfamily
SMULJ23_RS02755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMULJ23_RS02765	COG0557	exoribonuclease II activity
SMULJ23_RS02770	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SMULJ23_RS02775	COG0346	lactoylglutathione lyase activity
SMULJ23_RS02780	COG0778	Nitroreductase
SMULJ23_RS02790	COG2723	6-phospho-beta-galactosidase activity
SMULJ23_RS02795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMULJ23_RS02800	COG3711	transcriptional antiterminator
SMULJ23_RS02800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMULJ23_RS02805	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMULJ23_RS02815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMULJ23_RS02835	COG1609	Transcriptional regulator
SMULJ23_RS02850	COG0438	transferase activity, transferring glycosyl groups
SMULJ23_RS02860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMULJ23_RS02870	COG4716	Myosin-crossreactive antigen
SMULJ23_RS02875	COG1956	GAF domain-containing protein
SMULJ23_RS02880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SMULJ23_RS02905	COG0542	response to heat
SMULJ23_RS02920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SMULJ23_RS02925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMULJ23_RS02930	COG3842	ATPase activity
SMULJ23_RS02935	COG3833	ABC-type maltose transport systems, permease component
SMULJ23_RS02940	COG1175	transmembrane transport
SMULJ23_RS02950	COG1609	Transcriptional regulator
SMULJ23_RS02955	COG1640	4-alpha-glucanotransferase
SMULJ23_RS02960	COG0058	SHG alpha-glucan phosphorylase activity
SMULJ23_RS02965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SMULJ23_RS02970	COG0569	domain protein
SMULJ23_RS02990	COG4109	DRTGG domain
SMULJ23_RS03000	COG1295	ribonuclease BN
SMULJ23_RS03020	COG1131	(ABC) transporter
SMULJ23_RS03030	COG4585	Histidine kinase
SMULJ23_RS03035	COG2197	response regulator
SMULJ23_RS03045	COG4708	membrane
SMULJ23_RS03050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMULJ23_RS03055	COG1597	lipid kinase activity
SMULJ23_RS03060	COG1523	belongs to the glycosyl hydrolase 13 family
SMULJ23_RS03070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SMULJ23_RS03075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMULJ23_RS03080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SMULJ23_RS03085	COG0297	glycogen (starch) synthase activity
SMULJ23_RS03090	COG0058	SHG alpha-glucan phosphorylase activity
SMULJ23_RS03100	COG0356	it plays a direct role in the translocation of protons across the membrane
SMULJ23_RS03105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SMULJ23_RS03110	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SMULJ23_RS03115	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SMULJ23_RS03120	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SMULJ23_RS03125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SMULJ23_RS03130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SMULJ23_RS03140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SMULJ23_RS03155	COG0765	amino acid transport
SMULJ23_RS03160	COG0765	amino acid transport
SMULJ23_RS03165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMULJ23_RS03170	COG1126	abc transporter atp-binding protein
SMULJ23_RS03175	COG0745	RESPONSE REGULATOR receiver
SMULJ23_RS03180	COG5002	protein histidine kinase activity
SMULJ23_RS03185	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SMULJ23_RS03190	COG0571	ribonuclease III activity
SMULJ23_RS03195	COG1196	nuclear chromosome segregation
SMULJ23_RS03200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SMULJ23_RS03210	COG0072	phenylalanine-tRNA ligase activity
SMULJ23_RS03210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMULJ23_RS03215	COG1396	sequence-specific DNA binding
SMULJ23_RS03220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMULJ23_RS03245	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SMULJ23_RS03250	COG1074	ATP-dependent DNA helicase activity
SMULJ23_RS03255	COG1349	DNA-binding transcription factor activity
SMULJ23_RS03260	COG0698	ribose 5-phosphate isomerase
SMULJ23_RS03265	COG0698	ribose 5-phosphate isomerase
SMULJ23_RS03270	COG1105	Belongs to the carbohydrate kinase PfkB family
SMULJ23_RS03275	COG3684	Belongs to the aldolase LacD family
SMULJ23_RS03290	COG3775	system Galactitol-specific IIC component
SMULJ23_RS03295	COG1447	Phosphotransferase system cellobiose-specific component IIA
SMULJ23_RS03300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMULJ23_RS03300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SMULJ23_RS03305	COG2723	6-phospho-beta-galactosidase activity
SMULJ23_RS03330	COG1401	restriction endodeoxyribonuclease activity
SMULJ23_RS03360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SMULJ23_RS03365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMULJ23_RS03375	COG1234	tRNA 3'-trailer cleavage
SMULJ23_RS03380	COG0300	oxidoreductase activity
SMULJ23_RS03385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SMULJ23_RS03385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SMULJ23_RS03390	COG2378	regulation of single-species biofilm formation
SMULJ23_RS03410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMULJ23_RS03415	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
SMULJ23_RS03425	COG2384	SAM-dependent methyltransferase
SMULJ23_RS03435	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SMULJ23_RS03445	COG1088	dTDP-glucose 4,6-dehydratase activity
SMULJ23_RS03455	COG1051	belongs to the nudix hydrolase family
SMULJ23_RS03460	COG0628	permease
SMULJ23_RS03470	COG0028	Belongs to the TPP enzyme family
SMULJ23_RS03475	COG3527	Alpha-acetolactate decarboxylase
SMULJ23_RS03480	COG1113	amino acid transport
SMULJ23_RS03485	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SMULJ23_RS03520	COG4808	Protein conserved in bacteria
SMULJ23_RS03530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SMULJ23_RS03545	COG1215	transferase activity, transferring glycosyl groups
SMULJ23_RS03555	COG0488	(ABC) transporter
SMULJ23_RS03560	COG3442	glutamine amidotransferase
SMULJ23_RS03565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMULJ23_RS03570	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SMULJ23_RS03580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMULJ23_RS03585	COG0542	response to heat
SMULJ23_RS03595	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SMULJ23_RS03600	COG0022	dehydrogenase e1 component
SMULJ23_RS03605	COG0508	dehydrogenase complex catalyzes the overall conversion of
SMULJ23_RS03610	COG2249	NAD(P)H dehydrogenase (quinone) activity
SMULJ23_RS03620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SMULJ23_RS03630	COG1051	belongs to the nudix hydrolase family
SMULJ23_RS03635	COG0647	UMP catabolic process
SMULJ23_RS03645	COG1136	(ABC) transporter
SMULJ23_RS03645	COG0577	efflux transmembrane transporter activity
SMULJ23_RS03655	COG1053	succinate dehydrogenase
SMULJ23_RS03655	COG3976	FMN-binding domain protein
SMULJ23_RS03670	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SMULJ23_RS03675	COG1518	maintenance of DNA repeat elements
SMULJ23_RS03680	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMULJ23_RS03700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SMULJ23_RS03720	COG0481	GTPase activity
SMULJ23_RS03745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SMULJ23_RS03755	COG0673	inositol 2-dehydrogenase activity
SMULJ23_RS03760	COG0572	uridine kinase
SMULJ23_RS03770	COG0473	3-isopropylmalate dehydrogenase activity
SMULJ23_RS03775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SMULJ23_RS03780	COG0066	3-isopropylmalate dehydratase activity
SMULJ23_RS03795	COG0456	acetyltransferase
SMULJ23_RS03795	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SMULJ23_RS03805	COG2813	Specifically methylates the guanine in position
SMULJ23_RS03815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SMULJ23_RS03825	COG2884	Cell division ATP-binding protein ftsE
SMULJ23_RS03830	COG2177	Part of the ABC transporter FtsEX involved in
SMULJ23_RS03860	COG1122	ATPase activity
SMULJ23_RS03870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SMULJ23_RS03870	COG1199	ATP-dependent helicase activity
SMULJ23_RS03875	COG0436	Aminotransferase
SMULJ23_RS03880	COG0017	Asparaginyl-tRNA synthetase
SMULJ23_RS03885	COG0371	Dehydrogenase
SMULJ23_RS03890	COG0251	oxidation-reduction process
SMULJ23_RS03900	COG1660	Displays ATPase and GTPase activities
SMULJ23_RS03910	COG1481	regulation of sporulation
SMULJ23_RS03925	COG2226	methyltransferase
SMULJ23_RS03940	COG0254	rRNA binding
SMULJ23_RS03945	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SMULJ23_RS03950	COG0625	glutathione transferase activity
SMULJ23_RS03955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SMULJ23_RS03960	COG0716	FMN binding
SMULJ23_RS03975	COG0077	Prephenate dehydratase
SMULJ23_RS03975	COG1605	Chorismate mutase
SMULJ23_RS03980	COG0038	chloride channel
SMULJ23_RS03985	COG0038	chloride channel
SMULJ23_RS03990	COG0335	large ribosomal subunit rRNA binding
SMULJ23_RS04000	COG2814	Major facilitator Superfamily
SMULJ23_RS04025	COG0772	Belongs to the SEDS family
SMULJ23_RS04040	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SMULJ23_RS04060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SMULJ23_RS04065	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SMULJ23_RS04070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SMULJ23_RS04075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SMULJ23_RS04080	COG0560	Phosphoserine phosphatase
SMULJ23_RS04085	COG0131	Imidazoleglycerol-phosphate dehydratase
SMULJ23_RS04095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SMULJ23_RS04100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SMULJ23_RS04105	COG0107	imidazoleglycerol-phosphate synthase activity
SMULJ23_RS04110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SMULJ23_RS04150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMULJ23_RS04150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SMULJ23_RS04155	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMULJ23_RS04205	COG0148	phosphopyruvate hydratase activity
SMULJ23_RS04230	COG0322	excinuclease ABC activity
SMULJ23_RS04240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMULJ23_RS04245	COG1573	uracil-dna glycosylase
SMULJ23_RS04265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SMULJ23_RS04270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMULJ23_RS04275	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SMULJ23_RS04285	COG2267	carboxylic ester hydrolase activity
SMULJ23_RS04300	COG0813	purine-nucleoside phosphorylase activity
SMULJ23_RS04315	COG0543	2 iron, 2 sulfur cluster binding
SMULJ23_RS04320	COG0167	dihydroorotate dehydrogenase activity
SMULJ23_RS04325	COG0284	orotidine-5'-phosphate decarboxylase activity
SMULJ23_RS04330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMULJ23_RS04340	COG1881	PFAM PEBP family protein
SMULJ23_RS04345	COG2315	Protein conserved in bacteria
SMULJ23_RS04355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMULJ23_RS04360	COG0765	amino acid transport
SMULJ23_RS04365	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SMULJ23_RS04375	COG0737	Belongs to the 5'-nucleotidase family
SMULJ23_RS04380	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SMULJ23_RS04385	COG0187	DNA topoisomerase II activity
SMULJ23_RS04400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SMULJ23_RS04420	COG0539	negative regulation of cytoplasmic translation
SMULJ23_RS04445	COG1131	(ABC) transporter
SMULJ23_RS04450	COG1725	Transcriptional regulator
SMULJ23_RS04460	COG0205	6-phosphofructokinase activity
SMULJ23_RS04465	COG0469	pyruvate kinase activity
SMULJ23_RS04470	COG2261	transglycosylase associated protein
SMULJ23_RS04480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMULJ23_RS04485	COG2213	PTS system mannitol-specific
SMULJ23_RS04490	COG3711	transcriptional antiterminator
SMULJ23_RS04495	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMULJ23_RS04500	COG0246	Mannitol dehydrogenase
SMULJ23_RS04505	COG2824	Alkylphosphonate utilization operon protein PhnA
SMULJ23_RS04510	COG0765	amino acid transport
SMULJ23_RS04515	COG1126	abc transporter atp-binding protein
SMULJ23_RS04520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMULJ23_RS04525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SMULJ23_RS04530	COG1115	amino acid carrier protein
SMULJ23_RS04535	COG0210	DNA helicase
SMULJ23_RS04540	COG2873	o-acetylhomoserine
SMULJ23_RS04555	COG0785	Cytochrome C biogenesis protein
SMULJ23_RS04560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SMULJ23_RS04585	COG1132	(ABC) transporter
SMULJ23_RS04585	COG2375	cellular response to nickel ion
SMULJ23_RS04590	COG1132	(ABC) transporter
SMULJ23_RS04650	COG0745	RESPONSE REGULATOR receiver
SMULJ23_RS04655	COG2205	protein histidine kinase activity
SMULJ23_RS04660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SMULJ23_RS04665	COG0196	riboflavin kinase activity
SMULJ23_RS04670	COG1393	Belongs to the ArsC family
SMULJ23_RS04675	COG4476	Belongs to the UPF0223 family
SMULJ23_RS04680	COG0483	inositol monophosphate 1-phosphatase activity
SMULJ23_RS04685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMULJ23_RS04685	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SMULJ23_RS04695	COG0573	inorganic phosphate transmembrane transporter activity
SMULJ23_RS04700	COG0581	inorganic phosphate transmembrane transporter activity
SMULJ23_RS04705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMULJ23_RS04710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMULJ23_RS04715	COG0704	Plays a role in the regulation of phosphate uptake
SMULJ23_RS04730	COG0745	RESPONSE REGULATOR receiver
SMULJ23_RS04735	COG5002	protein histidine kinase activity
SMULJ23_RS04740	COG0268	Binds directly to 16S ribosomal RNA
SMULJ23_RS04745	COG1072	(Pantothenic acid kinase))
SMULJ23_RS04750	COG2813	Specifically methylates the guanine in position
SMULJ23_RS04755	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SMULJ23_RS04760	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMULJ23_RS04765	COG0295	cytidine deaminase activity
SMULJ23_RS04770	COG1744	ABC transporter substrate-binding protein PnrA-like
SMULJ23_RS04775	COG3845	ABC transporter
SMULJ23_RS04780	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMULJ23_RS04785	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMULJ23_RS04800	COG0039	L-malate dehydrogenase activity
SMULJ23_RS04810	COG3764	Sortase (surface protein transpeptidase)
SMULJ23_RS04815	COG0346	lactoylglutathione lyase activity
SMULJ23_RS04830	COG0561	phosphatase activity
SMULJ23_RS04850	COG0406	alpha-ribazole phosphatase activity
SMULJ23_RS04860	COG2723	6-phospho-beta-galactosidase activity
SMULJ23_RS04865	COG0628	permease
SMULJ23_RS04870	COG1063	alcohol dehydrogenase
SMULJ23_RS04885	COG1174	glycine betaine transport
SMULJ23_RS04890	COG1136	(ABC) transporter
SMULJ23_RS04895	COG0577	efflux transmembrane transporter activity
SMULJ23_RS04910	COG0431	NADPH-dependent FMN reductase
SMULJ23_RS04910	COG3976	FMN-binding domain protein
SMULJ23_RS04910	COG1053	succinate dehydrogenase
SMULJ23_RS04925	COG1942	4-Oxalocrotonate Tautomerase
SMULJ23_RS04930	COG1435	thymidine kinase activity
SMULJ23_RS04935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SMULJ23_RS04940	COG2890	protein-(glutamine-N5) methyltransferase activity
SMULJ23_RS04945	COG0009	L-threonylcarbamoyladenylate synthase
SMULJ23_RS04950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMULJ23_RS04965	COG1132	(ABC) transporter
SMULJ23_RS04970	COG1132	(ABC) transporter
SMULJ23_RS04975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMULJ23_RS04980	COG4684	Psort location CytoplasmicMembrane, score
SMULJ23_RS04985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMULJ23_RS04995	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SMULJ23_RS05000	COG1247	-acetyltransferase
SMULJ23_RS05020	COG1131	(ABC) transporter
SMULJ23_RS05030	COG0519	Catalyzes the synthesis of GMP from XMP
SMULJ23_RS05035	COG2188	Transcriptional regulator
SMULJ23_RS05045	COG4175	Glycine betaine
SMULJ23_RS05045	COG3448	diguanylate cyclase activity
SMULJ23_RS05055	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SMULJ23_RS05060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMULJ23_RS05085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SMULJ23_RS05090	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SMULJ23_RS05100	COG1104	cysteine desulfurase activity
SMULJ23_RS05105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMULJ23_RS05110	COG4116	CYTH
SMULJ23_RS05120	COG2357	RelA SpoT domain protein
SMULJ23_RS05125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMULJ23_RS05130	COG0564	pseudouridine synthase activity
SMULJ23_RS05135	COG0280	phosphate acetyltransferase
SMULJ23_RS05145	COG1131	(ABC) transporter
SMULJ23_RS05150	COG4221	oxidoreductase activity
SMULJ23_RS05155	COG1442	glycosyl transferase family 8
SMULJ23_RS05160	COG0745	RESPONSE REGULATOR receiver
SMULJ23_RS05165	COG5002	protein histidine kinase activity
SMULJ23_RS05175	COG1131	(ABC) transporter
SMULJ23_RS05180	COG4974	Belongs to the 'phage' integrase family
SMULJ23_RS05245	COG3052	prosthetic group binding
SMULJ23_RS05255	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SMULJ23_RS05260	COG0511	ligase activity, forming carbon-carbon bonds
SMULJ23_RS05270	COG2851	Citrate transporter
SMULJ23_RS05280	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SMULJ23_RS05285	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
SMULJ23_RS05290	COG0642	Histidine kinase
SMULJ23_RS05295	COG0745	RESPONSE REGULATOR receiver
SMULJ23_RS05305	COG1136	(ABC) transporter
SMULJ23_RS05310	COG5263	repeat protein
SMULJ23_RS05310	COG0366	Alpha amylase catalytic
SMULJ23_RS05315	COG5263	repeat protein
SMULJ23_RS05315	COG0366	Alpha amylase catalytic
SMULJ23_RS05320	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SMULJ23_RS05325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMULJ23_RS05330	COG0758	DNA mediated transformation
SMULJ23_RS05345	COG4607	ABC-type enterochelin transport system periplasmic component
SMULJ23_RS05350	COG4604	ABC transporter, ATP-binding protein
SMULJ23_RS05355	COG4605	iron ion homeostasis
SMULJ23_RS05360	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SMULJ23_RS05365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMULJ23_RS05370	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMULJ23_RS05385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SMULJ23_RS05390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SMULJ23_RS05400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SMULJ23_RS05405	COG4932	domain protein
SMULJ23_RS05435	COG1263	PTS System
SMULJ23_RS05435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMULJ23_RS05435	COG2190	(PTS) system
SMULJ23_RS05440	COG3711	transcriptional antiterminator
SMULJ23_RS05450	COG1177	transmembrane transport
SMULJ23_RS05455	COG1176	ABC-type spermidine putrescine transport system, permease component I
SMULJ23_RS05460	COG3842	ATPase activity
SMULJ23_RS05465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SMULJ23_RS05485	COG0302	gtp cyclohydrolase
SMULJ23_RS05490	COG0285	dihydrofolate synthase activity
SMULJ23_RS05495	COG0083	homoserine kinase activity
SMULJ23_RS05505	COG0726	polysaccharide deacetylase
SMULJ23_RS05510	COG1960	acyl-CoA dehydrogenase activity
SMULJ23_RS05520	COG0222	ribosome binding
SMULJ23_RS05525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SMULJ23_RS05545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMULJ23_RS05550	COG2040	homocysteine
SMULJ23_RS05555	COG0833	amino acid
SMULJ23_RS05560	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SMULJ23_RS05565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SMULJ23_RS05575	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SMULJ23_RS05580	COG3201	nicotinamide mononucleotide transporter
SMULJ23_RS05585	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SMULJ23_RS05590	COG3425	synthase
SMULJ23_RS05605	COG1272	protein, Hemolysin III
SMULJ23_RS05610	COG1304	FMN binding
SMULJ23_RS05625	COG1126	abc transporter atp-binding protein
SMULJ23_RS05630	COG0765	amino acid transport
SMULJ23_RS05635	COG0765	amino acid transport
SMULJ23_RS05640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMULJ23_RS05650	COG0583	DNA-binding transcription factor activity
SMULJ23_RS05655	COG3759	membrane
SMULJ23_RS05665	COG0745	RESPONSE REGULATOR receiver
SMULJ23_RS05670	COG2357	RelA SpoT domain protein
SMULJ23_RS05680	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SMULJ23_RS05685	COG1132	(ABC) transporter
SMULJ23_RS05700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SMULJ23_RS05710	COG0602	queuosine metabolic process
SMULJ23_RS05715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SMULJ23_RS05725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMULJ23_RS05735	COG0366	Alpha amylase catalytic
SMULJ23_RS05735	COG5263	repeat protein
SMULJ23_RS05745	COG1132	(ABC) transporter
SMULJ23_RS05760	COG0488	(ABC) transporter
SMULJ23_RS05765	COG0617	tRNA 3'-terminal CCA addition
SMULJ23_RS05770	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SMULJ23_RS05775	COG1307	EDD domain protein, DegV family
SMULJ23_RS05790	COG1131	(ABC) transporter
SMULJ23_RS05805	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMULJ23_RS05810	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SMULJ23_RS05815	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMULJ23_RS05820	COG1609	Transcriptional regulator
SMULJ23_RS05825	COG0366	Alpha amylase catalytic
SMULJ23_RS05830	COG3842	ATPase activity
SMULJ23_RS05835	COG0366	Alpha amylase catalytic
SMULJ23_RS05840	COG0395	ABC-type sugar transport system, permease component
SMULJ23_RS05845	COG1175	transmembrane transport
SMULJ23_RS05850	COG1653	transport
SMULJ23_RS05855	COG3345	alpha-galactosidase
SMULJ23_RS05860	COG2207	Transcriptional regulator
SMULJ23_RS05875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SMULJ23_RS05875	COG0646	methionine synthase
SMULJ23_RS05880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SMULJ23_RS05885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMULJ23_RS05885	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMULJ23_RS05885	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SMULJ23_RS05890	COG1105	Belongs to the carbohydrate kinase PfkB family
SMULJ23_RS05895	COG1349	DNA-binding transcription factor activity
SMULJ23_RS05900	COG0492	ferredoxin-NADP+ reductase activity
SMULJ23_RS05905	COG0336	Belongs to the RNA methyltransferase TrmD family
SMULJ23_RS05910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SMULJ23_RS05915	COG1837	Belongs to the UPF0109 family
SMULJ23_RS05920	COG0228	four-way junction DNA binding
SMULJ23_RS05925	COG0577	efflux transmembrane transporter activity
SMULJ23_RS05930	COG1136	(ABC) transporter
SMULJ23_RS05940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SMULJ23_RS05945	COG0505	Belongs to the CarA family
SMULJ23_RS05950	COG0540	Belongs to the ATCase OTCase family
SMULJ23_RS05960	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SMULJ23_RS05970	COG0564	pseudouridine synthase activity
SMULJ23_RS05975	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SMULJ23_RS05980	COG0583	DNA-binding transcription factor activity
SMULJ23_RS05985	COG2816	NAD+ diphosphatase activity
SMULJ23_RS05995	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SMULJ23_RS06005	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SMULJ23_RS06025	COG0301	tRNA thio-modification
SMULJ23_RS06030	COG1104	cysteine desulfurase activity
SMULJ23_RS06040	COG0285	dihydrofolate synthase activity
SMULJ23_RS06045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMULJ23_RS06050	COG0656	L-ascorbic acid biosynthetic process
SMULJ23_RS06055	COG3942	CHAP domain
SMULJ23_RS06080	COG0463	Glycosyl transferase, family 2
SMULJ23_RS06090	COG1368	sulfuric ester hydrolase activity
SMULJ23_RS06125	COG1091	dTDP-4-dehydrorhamnose reductase activity
SMULJ23_RS06130	COG0463	Glycosyl transferase, family 2
SMULJ23_RS06135	COG2151	metal-sulfur cluster biosynthetic enzyme
SMULJ23_RS06140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SMULJ23_RS06145	COG0358	DNA primase activity
SMULJ23_RS06155	COG1970	mechanosensitive ion channel activity
SMULJ23_RS06165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMULJ23_RS06175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SMULJ23_RS06200	COG0556	nucleotide-excision repair
SMULJ23_RS06215	COG1126	abc transporter atp-binding protein
SMULJ23_RS06220	COG0488	(ABC) transporter
SMULJ23_RS06230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMULJ23_RS06275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SMULJ23_RS06285	COG0077	Prephenate dehydratase
SMULJ23_RS06290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMULJ23_RS06295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SMULJ23_RS06300	COG3679	Belongs to the UPF0342 family
SMULJ23_RS06305	COG0287	Prephenate dehydrogenase
SMULJ23_RS06310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SMULJ23_RS06315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SMULJ23_RS06320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SMULJ23_RS06325	COG0710	3-dehydroquinate dehydratase activity
SMULJ23_RS06330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMULJ23_RS06335	COG1368	sulfuric ester hydrolase activity
SMULJ23_RS06345	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SMULJ23_RS06360	COG1914	H( )-stimulated, divalent metal cation uptake system
SMULJ23_RS06365	COG4443	Transcriptional Coactivator p15 (PC4)
SMULJ23_RS06380	COG0450	alkyl hydroperoxide reductase
SMULJ23_RS06385	COG0826	peptidase U32
SMULJ23_RS06410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SMULJ23_RS06415	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SMULJ23_RS06425	COG3091	SprT-like family
SMULJ23_RS06430	COG2183	response to ionizing radiation
SMULJ23_RS06445	COG0701	Predicted permease
SMULJ23_RS06450	COG3689	TIGRFAM TIGR03943 family protein
SMULJ23_RS06455	COG0477	Major facilitator Superfamily
SMULJ23_RS06460	COG0552	protein localization to endoplasmic reticulum
SMULJ23_RS06465	COG0561	phosphatase activity
SMULJ23_RS06470	COG0561	phosphatase activity
SMULJ23_RS06525	COG0604	alcohol dehydrogenase
SMULJ23_RS06540	COG0584	glycerophosphoryl diester phosphodiesterase
SMULJ23_RS06560	COG1078	dGTPase activity
SMULJ23_RS06570	COG2348	transferase activity, transferring amino-acyl groups
SMULJ23_RS06580	COG0149	triose-phosphate isomerase activity
SMULJ23_RS06585	COG2274	protein secretion by the type I secretion system
SMULJ23_RS06610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMULJ23_RS06615	COG0772	Belongs to the SEDS family
SMULJ23_RS06620	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SMULJ23_RS06640	COG3859	Proton-coupled thiamine transporter YuaJ
SMULJ23_RS06655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SMULJ23_RS06665	COG0588	phosphoglycerate mutase activity
SMULJ23_RS06670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SMULJ23_RS06675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SMULJ23_RS06680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SMULJ23_RS06685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SMULJ23_RS06705	COG2195	Cleaves the N-terminal amino acid of tripeptides
SMULJ23_RS06730	COG0656	L-ascorbic acid biosynthetic process
SMULJ23_RS06735	COG0656	L-ascorbic acid biosynthetic process
SMULJ23_RS06740	COG0789	Transcriptional regulator
SMULJ23_RS06745	COG1012	belongs to the aldehyde dehydrogenase family
SMULJ23_RS06750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMULJ23_RS06755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMULJ23_RS06765	COG0538	isocitrate dehydrogenase activity
SMULJ23_RS06770	COG0372	Belongs to the citrate synthase family
SMULJ23_RS06775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SMULJ23_RS06780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SMULJ23_RS06785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SMULJ23_RS06795	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SMULJ23_RS06800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SMULJ23_RS06805	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SMULJ23_RS06810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SMULJ23_RS06865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMULJ23_RS06875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SMULJ23_RS06880	COG4122	O-methyltransferase activity
SMULJ23_RS06885	COG0131	Imidazoleglycerol-phosphate dehydratase
SMULJ23_RS06885	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SMULJ23_RS06910	COG0604	alcohol dehydrogenase
SMULJ23_RS06910	COG3321	synthase
SMULJ23_RS06910	COG1028	Short-chain dehydrogenase reductase Sdr
SMULJ23_RS06915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMULJ23_RS06920	COG3153	acetyltransferase
SMULJ23_RS06925	COG1187	pseudouridine synthase activity
SMULJ23_RS06935	COG0363	glucosamine-6-phosphate deaminase activity
SMULJ23_RS06945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SMULJ23_RS06970	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SMULJ23_RS06985	COG0658	competence protein
SMULJ23_RS06985	COG2333	competence protein COMEC
SMULJ23_RS06990	COG1596	polysaccharide export
SMULJ23_RS06990	COG1555	photosystem II stabilization
SMULJ23_RS06995	COG0204	Acyl-transferase
SMULJ23_RS07000	COG0726	polysaccharide deacetylase
SMULJ23_RS07010	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SMULJ23_RS07045	COG0513	Belongs to the DEAD box helicase family
SMULJ23_RS07050	COG3064	Membrane
SMULJ23_RS07050	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SMULJ23_RS07060	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SMULJ23_RS07080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SMULJ23_RS07085	COG0385	Bile acid
SMULJ23_RS07095	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMULJ23_RS07100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SMULJ23_RS07105	COG0768	penicillin binding
SMULJ23_RS07110	COG0588	phosphoglycerate mutase activity
SMULJ23_RS07125	COG0735	belongs to the Fur family
SMULJ23_RS07145	COG0776	regulation of translation
SMULJ23_RS07155	COG2755	lipolytic protein G-D-S-L family
SMULJ23_RS07160	COG1307	EDD domain protein, DegV family
SMULJ23_RS07165	COG0497	DNA recombination
SMULJ23_RS07170	COG1438	arginine binding
SMULJ23_RS07175	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
SMULJ23_RS07185	COG1722	exodeoxyribonuclease VII activity
SMULJ23_RS07190	COG1570	exodeoxyribonuclease VII activity
SMULJ23_RS07195	COG3275	phosphorelay sensor kinase activity
SMULJ23_RS07200	COG3279	Response regulator of the LytR AlgR family
SMULJ23_RS07205	COG1380	Effector of murein hydrolase LrgA
SMULJ23_RS07210	COG1346	cytolysis
SMULJ23_RS07215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMULJ23_RS07220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMULJ23_RS07225	COG0300	oxidoreductase activity
SMULJ23_RS07230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SMULJ23_RS07240	COG0697	spore germination
SMULJ23_RS07245	COG1959	2 iron, 2 sulfur cluster binding
SMULJ23_RS07250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMULJ23_RS07255	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SMULJ23_RS07275	COG1126	abc transporter atp-binding protein
SMULJ23_RS07280	COG0765	amino acid transport
SMULJ23_RS07285	COG4703	Protein of unknown function (DUF1797)
SMULJ23_RS07290	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMULJ23_RS07295	COG0542	response to heat
SMULJ23_RS07315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMULJ23_RS07320	COG3599	regulation of cell shape
SMULJ23_RS07325	COG2302	S4 RNA-binding domain
SMULJ23_RS07335	COG1799	cell septum assembly
SMULJ23_RS07340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SMULJ23_RS07350	COG0849	cell division
SMULJ23_RS07360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SMULJ23_RS07365	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SMULJ23_RS07375	COG1217	gtp-binding protein TYPA
SMULJ23_RS07380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SMULJ23_RS07385	COG1940	carbohydrate kinase activity
SMULJ23_RS07395	COG0783	Belongs to the Dps family
SMULJ23_RS07405	COG0159	tryptophan synthase activity
SMULJ23_RS07410	COG0133	tryptophan synthase activity
SMULJ23_RS07415	COG0135	phosphoribosylanthranilate isomerase activity
SMULJ23_RS07420	COG0134	indole-3-glycerol-phosphate synthase activity
SMULJ23_RS07425	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SMULJ23_RS07430	COG0512	Glutamine amidotransferase of anthranilate synthase
SMULJ23_RS07435	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SMULJ23_RS07455	COG3804	dihydrodipicolinate reductase
SMULJ23_RS07460	COG0789	Transcriptional regulator
SMULJ23_RS07465	COG1132	(ABC) transporter
SMULJ23_RS07470	COG1132	(ABC) transporter
SMULJ23_RS07480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SMULJ23_RS07485	COG4470	Protein conserved in bacteria
SMULJ23_RS07490	COG0737	Belongs to the 5'-nucleotidase family
SMULJ23_RS07495	COG3480	Lon protease (S16) C-terminal proteolytic domain
SMULJ23_RS07500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMULJ23_RS07505	COG0742	ribosomal rna small subunit methyltransferase
SMULJ23_RS07510	COG4716	Myosin-crossreactive antigen
SMULJ23_RS07565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMULJ23_RS07575	COG0561	phosphatase activity
SMULJ23_RS07580	COG1349	DNA-binding transcription factor activity
SMULJ23_RS07625	COG1040	competence protein
SMULJ23_RS07630	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SMULJ23_RS07635	COG1739	Uncharacterized protein family UPF0029
SMULJ23_RS07655	COG1882	Formate acetyltransferase
SMULJ23_RS07660	COG1349	DNA-binding transcription factor activity
SMULJ23_RS07665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SMULJ23_RS07670	COG1098	S1 RNA binding domain
SMULJ23_RS07680	COG2197	response regulator
SMULJ23_RS07685	COG4585	Histidine kinase
SMULJ23_RS07705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMULJ23_RS07705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMULJ23_RS07710	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SMULJ23_RS07715	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SMULJ23_RS07720	COG1758	RNA polymerase activity
SMULJ23_RS07725	COG0194	GDP metabolic process
SMULJ23_RS07730	COG4372	Transposase
SMULJ23_RS07730	COG1418	mRNA catabolic process
SMULJ23_RS07735	COG1854	S-ribosylhomocysteine lyase activity
SMULJ23_RS07745	COG0116	Belongs to the methyltransferase superfamily
SMULJ23_RS07750	COG3599	regulation of cell shape
SMULJ23_RS07755	COG4474	Belongs to the UPF0398 family
SMULJ23_RS07760	COG3331	DNA recombination
SMULJ23_RS07765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SMULJ23_RS07770	COG3579	cysteine-type endopeptidase activity
SMULJ23_RS07775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMULJ23_RS07780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SMULJ23_RS07785	COG0492	ferredoxin-NADP+ reductase activity
SMULJ23_RS07795	COG1126	abc transporter atp-binding protein
SMULJ23_RS07810	COG0513	Belongs to the DEAD box helicase family
SMULJ23_RS07815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMULJ23_RS07820	COG0768	penicillin binding
SMULJ23_RS07825	COG4839	cell division protein FtsL
SMULJ23_RS07830	COG0275	rRNA processing
SMULJ23_RS07835	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SMULJ23_RS07840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SMULJ23_RS07850	COG4224	UPF0291 protein
SMULJ23_RS07855	COG0751	glycine-tRNA ligase activity
SMULJ23_RS07860	COG0752	glycyl-tRNA synthetase alpha subunit
SMULJ23_RS07865	COG1673	EVE domain
SMULJ23_RS07885	COG1924	4 iron, 4 sulfur cluster binding
SMULJ23_RS07910	COG1131	(ABC) transporter
SMULJ23_RS07920	COG0561	phosphatase activity
SMULJ23_RS07930	COG2217	Heavy metal translocating P-type atpase
SMULJ23_RS07945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SMULJ23_RS07950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SMULJ23_RS07960	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SMULJ23_RS07965	COG0195	Participates in both transcription termination and antitermination
SMULJ23_RS07970	COG0779	Required for maturation of 30S ribosomal subunits
SMULJ23_RS07980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SMULJ23_RS07990	COG4473	ABC transporter
SMULJ23_RS07995	COG1131	(ABC) transporter
SMULJ23_RS08000	COG0537	adenosine 5'-monophosphoramidase activity
SMULJ23_RS08010	COG1316	TRANSCRIPTIONal
SMULJ23_RS08015	COG0802	atpase or kinase
SMULJ23_RS08020	COG2252	PERMEase
SMULJ23_RS08030	COG0561	phosphatase activity
SMULJ23_RS08045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SMULJ23_RS08050	COG1882	Formate acetyltransferase
SMULJ23_RS08060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SMULJ23_RS08075	COG2936	dipeptidyl-peptidase activity
SMULJ23_RS08120	COG0582	viral genome integration into host DNA
SMULJ23_RS08125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SMULJ23_RS08135	COG2081	HI0933 family
SMULJ23_RS08155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SMULJ23_RS08160	COG0456	acetyltransferase
SMULJ23_RS08165	COG1214	PFAM Peptidase M22, glycoprotease
SMULJ23_RS08175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SMULJ23_RS08200	COG5503	Protein of unknown function (DUF1447)
SMULJ23_RS08210	COG3942	CHAP domain
SMULJ23_RS08215	COG0493	'glutamate synthase
SMULJ23_RS08220	COG0067	glutamate synthase
SMULJ23_RS08220	COG0070	glutamate synthase
SMULJ23_RS08220	COG0069	glutamate synthase activity
SMULJ23_RS08225	COG0174	glutamine synthetase
SMULJ23_RS08230	COG0789	Transcriptional regulator
SMULJ23_RS08240	COG0126	phosphoglycerate kinase activity
SMULJ23_RS08250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMULJ23_RS08255	COG0049	tRNA binding
SMULJ23_RS08260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SMULJ23_RS08265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMULJ23_RS08290	COG1162	GTPase activity
SMULJ23_RS08310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMULJ23_RS08325	COG0084	hydrolase, TatD family'
SMULJ23_RS08330	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SMULJ23_RS08345	COG0706	membrane insertase activity
SMULJ23_RS08350	COG0594	ribonuclease P activity
SMULJ23_RS08355	COG0165	Argininosuccinate lyase
SMULJ23_RS08360	COG0137	argininosuccinate synthase activity
SMULJ23_RS08375	COG1827	regulation of RNA biosynthetic process
SMULJ23_RS08380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMULJ23_RS08405	COG0756	dUTP diphosphatase activity
SMULJ23_RS08410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SMULJ23_RS08415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SMULJ23_RS08420	COG0705	Rhomboid family
SMULJ23_RS08420	COG0457	Tetratricopeptide repeat
SMULJ23_RS08425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SMULJ23_RS08435	COG1473	amidohydrolase
SMULJ23_RS08440	COG2171	N-acyltransferase activity
SMULJ23_RS08455	COG3732	PTS system glucitol sorbitol-specific
SMULJ23_RS08460	COG3730	PTS system glucitol sorbitol-specific
SMULJ23_RS08470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMULJ23_RS08470	COG3711	transcriptional antiterminator
SMULJ23_RS08480	COG0166	Belongs to the GPI family
SMULJ23_RS08495	COG1234	tRNA 3'-trailer cleavage
SMULJ23_RS08510	COG0343	queuine tRNA-ribosyltransferase activity
SMULJ23_RS08520	COG1832	CoA-binding protein
SMULJ23_RS08525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMULJ23_RS08525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMULJ23_RS08540	COG0583	DNA-binding transcription factor activity
SMULJ23_RS08570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SMULJ23_RS08590	COG2274	protein secretion by the type I secretion system
SMULJ23_RS08625	COG3623	hexulose-6-phosphate isomerase
SMULJ23_RS08635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SMULJ23_RS08650	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SMULJ23_RS08655	COG2918	glutathione biosynthetic process
SMULJ23_RS08655	COG1181	Belongs to the D-alanine--D-alanine ligase family
SMULJ23_RS08665	COG2957	Belongs to the agmatine deiminase family
SMULJ23_RS08670	COG0531	amino acid
SMULJ23_RS08675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMULJ23_RS08690	COG4608	Belongs to the ABC transporter superfamily
SMULJ23_RS08695	COG0444	Belongs to the ABC transporter superfamily
SMULJ23_RS08700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMULJ23_RS08705	COG0601	transmembrane transport
SMULJ23_RS08710	COG4166	transmembrane transport
SMULJ23_RS08725	COG0719	Fe-S assembly protein
SMULJ23_RS08735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMULJ23_RS08740	COG0719	Fe-S assembly protein
SMULJ23_RS08750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMULJ23_RS08755	COG4862	establishment of competence for transformation
SMULJ23_RS08760	COG1968	undecaprenyl-diphosphatase activity
SMULJ23_RS08770	COG0765	amino acid transport
SMULJ23_RS08775	COG1126	abc transporter atp-binding protein
SMULJ23_RS08785	COG1131	(ABC) transporter
SMULJ23_RS08795	COG1309	transcriptional regulator
SMULJ23_RS08805	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMULJ23_RS08810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SMULJ23_RS08815	COG0440	acetolactate synthase activity
SMULJ23_RS08820	COG0028	Belongs to the TPP enzyme family
SMULJ23_RS08945	COG0203	ribosomal protein L17
SMULJ23_RS08950	COG0202	RNA polymerase activity
SMULJ23_RS08955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMULJ23_RS08960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMULJ23_RS08970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SMULJ23_RS08975	COG0563	adenylate kinase activity
SMULJ23_RS08980	COG0201	protein transport
SMULJ23_RS08985	COG0200	Binds to the 23S rRNA
SMULJ23_RS08990	COG1841	ribosomal large subunit assembly
SMULJ23_RS08995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMULJ23_RS09005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMULJ23_RS09010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SMULJ23_RS09015	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SMULJ23_RS09020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMULJ23_RS09025	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SMULJ23_RS09030	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMULJ23_RS09035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SMULJ23_RS09040	COG0255	Belongs to the universal ribosomal protein uL29 family
SMULJ23_RS09045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMULJ23_RS09050	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMULJ23_RS09055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMULJ23_RS09065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SMULJ23_RS09070	COG0089	rRNA binding
SMULJ23_RS09080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMULJ23_RS09085	COG0051	transcription antitermination factor activity, RNA binding
SMULJ23_RS09095	COG1621	beta-fructofuranosidase activity
SMULJ23_RS09100	COG0542	response to heat
SMULJ23_RS09105	COG4463	regulation of RNA biosynthetic process
SMULJ23_RS09110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SMULJ23_RS09115	COG0052	Belongs to the universal ribosomal protein uS2 family
SMULJ23_RS09130	COG1619	proteins homologs of microcin C7 resistance protein MccF
SMULJ23_RS09135	COG3590	peptidase
SMULJ23_RS09145	COG0366	Alpha amylase catalytic
SMULJ23_RS09150	COG1263	PTS System
SMULJ23_RS09150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMULJ23_RS09155	COG2188	Transcriptional regulator
SMULJ23_RS09160	COG5297	Belongs to the glycosyl hydrolase family 6
SMULJ23_RS09165	COG1490	D-aminoacyl-tRNA deacylase activity
SMULJ23_RS09180	COG1263	PTS System
SMULJ23_RS09180	COG2190	(PTS) system
SMULJ23_RS09180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SMULJ23_RS09190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SMULJ23_RS09195	COG2264	protein methyltransferase activity
SMULJ23_RS09215	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMULJ23_RS09225	COG2217	Heavy metal translocating P-type atpase
SMULJ23_RS09235	COG2855	membrane
SMULJ23_RS09240	COG0583	DNA-binding transcription factor activity
SMULJ23_RS09250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SMULJ23_RS09260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMULJ23_RS09270	COG0463	Glycosyl transferase, family 2
SMULJ23_RS09285	COG4932	domain protein
SMULJ23_RS09285	COG1388	LysM domain
SMULJ23_RS09290	COG0428	transporter
SMULJ23_RS09295	COG3022	response to hydroperoxide
SMULJ23_RS09330	COG3906	Belongs to the UPF0473 family
SMULJ23_RS09335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SMULJ23_RS09340	COG4472	Bacterial protein of unknown function (DUF965)
SMULJ23_RS09360	COG1393	Belongs to the ArsC family
SMULJ23_RS09365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SMULJ23_RS09370	COG1058	Belongs to the CinA family
SMULJ23_RS09370	COG1546	Belongs to the CinA family
SMULJ23_RS09375	COG0519	Catalyzes the synthesis of GMP from XMP
SMULJ23_RS09380	COG0632	four-way junction helicase activity
SMULJ23_RS09385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SMULJ23_RS09395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SMULJ23_RS09405	COG1438	arginine binding
SMULJ23_RS09415	COG0549	Belongs to the carbamate kinase family
SMULJ23_RS09425	COG2235	arginine
SMULJ23_RS09450	COG0018	arginyl-trna synthetase
SMULJ23_RS09455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMULJ23_RS09460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SMULJ23_RS09465	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SMULJ23_RS09470	COG0124	histidyl-tRNA synthetase
SMULJ23_RS09475	COG0531	amino acid
SMULJ23_RS09485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SMULJ23_RS09500	COG0640	Transcriptional regulator
SMULJ23_RS09540	COG2801	Transposase and inactivated derivatives
SMULJ23_RS09550	COG2801	Transposase and inactivated derivatives
SMULJ23_RS09555	COG2801	Transposase and inactivated derivatives
SMULJ23_RS09560	COG0463	Glycosyl transferase, family 2
SMULJ23_RS09580	COG0789	Transcriptional regulator
SMULJ23_RS09585	COG1028	Short-chain dehydrogenase reductase Sdr
SMULJ23_RS09610	COG2094	Belongs to the DNA glycosylase MPG family
SMULJ23_RS09635	COG1012	belongs to the aldehyde dehydrogenase family
SMULJ23_RS09640	COG0129	dihydroxy-acid dehydratase activity
SMULJ23_RS09645	COG2151	metal-sulfur cluster biosynthetic enzyme
SMULJ23_RS09665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMULJ23_RS09675	COG0305	Participates in initiation and elongation during chromosome replication
SMULJ23_RS09680	COG0359	binds to the 23S rRNA
SMULJ23_RS09690	COG0445	tRNA wobble uridine modification
SMULJ23_RS09700	COG0482	sulfurtransferase activity
SMULJ23_RS09705	COG0741	lytic transglycosylase activity
SMULJ23_RS09715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SMULJ23_RS09720	COG1122	ATPase activity
SMULJ23_RS09725	COG1122	ATPase activity
SMULJ23_RS09730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMULJ23_RS09740	COG0612	Peptidase, M16
SMULJ23_RS09755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMULJ23_RS09760	COG0517	IMP dehydrogenase activity
SMULJ23_RS09760	COG0516	GMP reductase activity
SMULJ23_RS09765	COG0180	Tryptophanyl-tRNA synthetase
SMULJ23_RS09770	COG0488	(ABC) transporter
SMULJ23_RS09800	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SMULJ23_RS09805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SMULJ23_RS09810	COG1475	DNA binding