locus-tag	class	description
FNL60_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FNL60_RS00010	COG0592	DNA-directed DNA polymerase activity
FNL60_RS00020	COG0012	GTP binding
FNL60_RS00025	COG0193	aminoacyl-tRNA hydrolase activity
FNL60_RS00030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FNL60_RS00035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FNL60_RS00055	COG0037	tRNA processing
FNL60_RS00060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FNL60_RS00065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FNL60_RS00070	COG0531	amino acid
FNL60_RS00185	COG1792	Involved in formation and maintenance of cell shape
FNL60_RS00195	COG3942	CHAP domain
FNL60_RS00200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FNL60_RS00205	COG0436	Aminotransferase
FNL60_RS00210	COG1381	Involved in DNA repair and RecF pathway recombination
FNL60_RS00215	COG0416	fatty acid biosynthetic process
FNL60_RS00220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNL60_RS00225	COG2274	protein secretion by the type I secretion system
FNL60_RS00230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FNL60_RS00235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FNL60_RS00245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FNL60_RS00250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FNL60_RS00255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FNL60_RS00265	COG0138	bifunctional purine biosynthesis protein purh
FNL60_RS00285	COG0653	protein targeting
FNL60_RS00305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FNL60_RS00320	COG1794	racemase activity, acting on amino acids and derivatives
FNL60_RS00345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FNL60_RS00390	COG2255	four-way junction helicase activity
FNL60_RS00395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FNL60_RS00430	COG0534	Mate efflux family protein
FNL60_RS00435	COG3830	Belongs to the UPF0237 family
FNL60_RS00440	COG2848	UPF0210 protein
FNL60_RS00455	COG1705	Flagellar rod assembly protein muramidase FlgJ
FNL60_RS00465	COG3583	domain protein
FNL60_RS00465	COG5492	domain, Protein
FNL60_RS00465	COG1621	beta-fructofuranosidase activity
FNL60_RS00475	COG1420	regulation of RNA biosynthetic process
FNL60_RS00480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FNL60_RS00490	COG0443	Heat shock 70 kDa protein
FNL60_RS00495	COG0484	heat shock protein binding
FNL60_RS00500	COG0101	tRNA pseudouridine synthase activity
FNL60_RS00505	COG0351	phosphomethylpyrimidine kinase
FNL60_RS00510	COG4720	Psort location CytoplasmicMembrane, score
FNL60_RS00515	COG4475	Protein of unknown function (DUF436)
FNL60_RS00520	COG0668	transmembrane transport
FNL60_RS00530	COG0544	peptidyl-prolyl cis-trans isomerase activity
FNL60_RS00540	COG3343	RNA polymerase activity
FNL60_RS00545	COG0504	CTP synthase activity
FNL60_RS00555	COG0191	fructose-bisphosphate aldolase activity
FNL60_RS00565	COG3715	PTS system
FNL60_RS00615	COG1396	sequence-specific DNA binding
FNL60_RS00625	COG1105	Belongs to the carbohydrate kinase PfkB family
FNL60_RS00630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNL60_RS00630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNL60_RS00630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNL60_RS00635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNL60_RS00635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNL60_RS00635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNL60_RS00640	COG3684	Belongs to the aldolase LacD family
FNL60_RS00655	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
FNL60_RS00660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FNL60_RS00665	COG0534	Mate efflux family protein
FNL60_RS00670	COG2176	DNA-directed DNA polymerase activity
FNL60_RS00675	COG1846	Transcriptional regulator
FNL60_RS00680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FNL60_RS00685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FNL60_RS00690	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNL60_RS00690	COG0022	dehydrogenase e1 component
FNL60_RS00705	COG0095	Lipoate-protein ligase
FNL60_RS00710	COG1473	amidohydrolase
FNL60_RS00715	COG0477	Major facilitator Superfamily
FNL60_RS00720	COG1309	transcriptional regulator
FNL60_RS00725	COG0583	DNA-binding transcription factor activity
FNL60_RS00735	COG0281	malic enzyme
FNL60_RS00740	COG0679	Auxin Efflux Carrier
FNL60_RS00745	COG2140	Oxalate decarboxylase
FNL60_RS00760	COG0242	peptide deformylase activity
FNL60_RS00765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNL60_RS00775	COG1454	alcohol dehydrogenase
FNL60_RS00775	COG1012	belongs to the aldehyde dehydrogenase family
FNL60_RS00805	COG1733	regulation of RNA biosynthetic process
FNL60_RS00810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FNL60_RS00815	COG1185	polyribonucleotide nucleotidyltransferase activity
FNL60_RS00825	COG1045	serine acetyltransferase
FNL60_RS00830	COG0215	cysteine-tRNA ligase activity
FNL60_RS00835	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FNL60_RS00840	COG5504	Zn-dependent protease
FNL60_RS00860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FNL60_RS00880	COG1476	TRANSCRIPTIONal
FNL60_RS00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FNL60_RS00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FNL60_RS00900	COG4974	Belongs to the 'phage' integrase family
FNL60_RS00920	COG3942	CHAP domain
FNL60_RS00920	COG1705	Flagellar rod assembly protein muramidase FlgJ
FNL60_RS00935	COG0433	COG0433 Predicted ATPase
FNL60_RS00975	COG4115	mRNA cleavage
FNL60_RS00985	COG1674	ftsk spoiiie
FNL60_RS01025	COG1396	sequence-specific DNA binding
FNL60_RS01090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FNL60_RS01100	COG3976	FMN-binding domain protein
FNL60_RS01100	COG1053	succinate dehydrogenase
FNL60_RS01100	COG0431	NADPH-dependent FMN reductase
FNL60_RS01105	COG0431	NADPH-dependent FMN reductase
FNL60_RS01105	COG3976	FMN-binding domain protein
FNL60_RS01105	COG1053	succinate dehydrogenase
FNL60_RS01110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FNL60_RS01125	COG0803	Belongs to the bacterial solute-binding protein 9 family
FNL60_RS01135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FNL60_RS01140	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FNL60_RS01180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FNL60_RS01190	COG1121	(ABC) transporter
FNL60_RS01195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FNL60_RS01200	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FNL60_RS01205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNL60_RS01210	COG0085	RNA polymerase activity
FNL60_RS01215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FNL60_RS01225	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FNL60_RS01230	COG1459	type II secretion system
FNL60_RS01260	COG0827	DNA restriction-modification system
FNL60_RS01265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FNL60_RS01285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FNL60_RS01290	COG1363	Peptidase, m42
FNL60_RS01300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FNL60_RS01305	COG0072	phenylalanine-tRNA ligase activity
FNL60_RS01305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNL60_RS01310	COG1846	Transcriptional regulator
FNL60_RS01330	COG4585	Histidine kinase
FNL60_RS01335	COG2197	response regulator
FNL60_RS01365	COG3715	PTS system
FNL60_RS01370	COG3716	PTS system mannose fructose sorbose family IID component
FNL60_RS01380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FNL60_RS01385	COG0459	protein refolding
FNL60_RS01395	COG0564	pseudouridine synthase activity
FNL60_RS01400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNL60_RS01430	COG0495	leucyl-tRNA aminoacylation
FNL60_RS01435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNL60_RS01440	COG1464	Belongs to the NlpA lipoprotein family
FNL60_RS01445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNL60_RS01450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FNL60_RS01460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FNL60_RS01470	COG4720	Psort location CytoplasmicMembrane, score
FNL60_RS01475	COG1122	ATPase activity
FNL60_RS01485	COG0357	Ribosomal RNA small subunit methyltransferase G
FNL60_RS01490	COG1704	LemA family
FNL60_RS01495	COG0501	Belongs to the peptidase M48B family
FNL60_RS01500	COG4591	ABC-type transport system involved in lipoprotein release permease component
FNL60_RS01505	COG1136	(ABC) transporter
FNL60_RS01520	COG0745	RESPONSE REGULATOR receiver
FNL60_RS01525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FNL60_RS01535	COG1484	DNA-dependent DNA replication
FNL60_RS01540	COG1160	GTP binding
FNL60_RS01550	COG0586	Pfam SNARE associated Golgi protein
FNL60_RS01560	COG3290	protein histidine kinase activity
FNL60_RS01640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FNL60_RS01660	COG3716	PTS system mannose fructose sorbose family IID component
FNL60_RS01665	COG3715	PTS system
FNL60_RS01680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FNL60_RS01685	COG0681	Belongs to the peptidase S26 family
FNL60_RS01690	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FNL60_RS01705	COG1193	negative regulation of DNA recombination
FNL60_RS01710	COG3118	belongs to the thioredoxin family
FNL60_RS01715	COG1063	alcohol dehydrogenase
FNL60_RS01720	COG1194	a g-specific adenine glycosylase
FNL60_RS01735	COG0360	Binds together with S18 to 16S ribosomal RNA
FNL60_RS01740	COG0629	single-stranded DNA binding
FNL60_RS01745	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FNL60_RS01780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FNL60_RS01785	COG0006	proline dipeptidase activity
FNL60_RS01790	COG2131	deaminase
FNL60_RS01795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FNL60_RS01800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FNL60_RS01810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FNL60_RS01815	COG1609	Transcriptional regulator
FNL60_RS01820	COG1621	beta-fructofuranosidase activity
FNL60_RS01825	COG2190	(PTS) system
FNL60_RS01825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FNL60_RS01825	COG1263	PTS System
FNL60_RS01830	COG1940	carbohydrate kinase activity
FNL60_RS01835	COG1482	cell wall glycoprotein biosynthetic process
FNL60_RS01840	COG0653	protein targeting
FNL60_RS01845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FNL60_RS01850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FNL60_RS01855	COG0736	holo-[acyl-carrier-protein] synthase activity
FNL60_RS01860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FNL60_RS01865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FNL60_RS01875	COG0252	asparaginase activity
FNL60_RS01880	COG0561	phosphatase activity
FNL60_RS01890	COG1268	BioY protein
FNL60_RS01895	COG0436	Aminotransferase
FNL60_RS01900	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FNL60_RS01905	COG1335	isochorismatase
FNL60_RS01910	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FNL60_RS01915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FNL60_RS01920	COG0154	amidase activity
FNL60_RS01925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FNL60_RS01930	COG0697	spore germination
FNL60_RS01935	COG1819	glycosyl
FNL60_RS01955	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FNL60_RS01960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FNL60_RS01965	COG1534	Rna-binding protein
FNL60_RS01970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FNL60_RS01975	COG1713	HD superfamily hydrolase involved in NAD metabolism
FNL60_RS01980	COG0799	negative regulation of ribosome biogenesis
FNL60_RS01985	COG2226	methyltransferase
FNL60_RS02000	COG1323	Belongs to the UPF0348 family
FNL60_RS02005	COG0789	Transcriptional regulator
FNL60_RS02010	COG0217	transcriptional regulatory protein
FNL60_RS02020	COG1862	Preprotein translocase
FNL60_RS02025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FNL60_RS02030	COG4589	Belongs to the CDS family
FNL60_RS02040	COG0442	prolyl-tRNA aminoacylation
FNL60_RS02095	COG3557	Belongs to the UPF0374 family
FNL60_RS02100	COG2137	regulation of response to DNA damage stimulus
FNL60_RS02105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FNL60_RS02110	COG1780	Probably involved in ribonucleotide reductase function
FNL60_RS02160	COG0525	valine-tRNA ligase activity
FNL60_RS02215	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FNL60_RS02300	COG0527	aspartate kinase activity
FNL60_RS02305	COG0546	phosphoglycolate phosphatase activity
FNL60_RS02310	COG1024	Enoyl-CoA hydratase
FNL60_RS02315	COG1846	Transcriptional regulator
FNL60_RS02320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FNL60_RS02335	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FNL60_RS02340	COG1028	Short-chain dehydrogenase reductase Sdr
FNL60_RS02345	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FNL60_RS02355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FNL60_RS02360	COG0439	Biotin carboxylase
FNL60_RS02375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FNL60_RS02385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FNL60_RS02395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FNL60_RS02400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FNL60_RS02405	COG0706	membrane insertase activity
FNL60_RS02410	COG1254	Belongs to the acylphosphatase family
FNL60_RS02415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FNL60_RS02430	COG0019	diaminopimelate decarboxylase activity
FNL60_RS02435	COG3763	UPF0154 protein
FNL60_RS02440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FNL60_RS02445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FNL60_RS02460	COG0582	viral genome integration into host DNA
FNL60_RS02465	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FNL60_RS02470	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FNL60_RS02475	COG1187	pseudouridine synthase activity
FNL60_RS02480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FNL60_RS02485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FNL60_RS02490	COG0569	domain protein
FNL60_RS02515	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
FNL60_RS02520	COG0671	phosphoesterase, PA-phosphatase related
FNL60_RS02530	COG1346	cytolysis
FNL60_RS02535	COG1242	4 iron, 4 sulfur cluster binding
FNL60_RS02540	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FNL60_RS02545	COG1119	ATPase activity
FNL60_RS02550	COG0628	permease
FNL60_RS02555	COG1253	flavin adenine dinucleotide binding
FNL60_RS02560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FNL60_RS02570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FNL60_RS02575	COG1696	Membrane protein involved in D-alanine export
FNL60_RS02580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FNL60_RS02585	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FNL60_RS02590	COG1227	inorganic diphosphatase activity
FNL60_RS02600	COG2378	regulation of single-species biofilm formation
FNL60_RS02605	COG0693	protein deglycase activity
FNL60_RS02630	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FNL60_RS02635	COG2244	polysaccharide biosynthetic process
FNL60_RS02640	COG0626	cystathionine gamma-synthase activity
FNL60_RS02645	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
FNL60_RS02650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FNL60_RS02655	COG0740	serine-type endopeptidase activity
FNL60_RS02665	COG4471	UPF0298 protein
FNL60_RS02675	COG0559	Belongs to the binding-protein-dependent transport system permease family
FNL60_RS02695	COG0517	IMP dehydrogenase activity
FNL60_RS02700	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FNL60_RS02705	COG0470	DNA polymerase III
FNL60_RS02710	COG1774	PSP1 C-terminal conserved region
FNL60_RS02715	COG4467	Involved in initiation control of chromosome replication
FNL60_RS02725	COG0004	ammonium transporteR
FNL60_RS02730	COG0347	Belongs to the P(II) protein family
FNL60_RS02735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FNL60_RS02750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FNL60_RS02755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FNL60_RS02760	COG1393	Belongs to the ArsC family
FNL60_RS02765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FNL60_RS02770	COG0708	Exodeoxyribonuclease III
FNL60_RS02780	COG0640	Transcriptional regulator
FNL60_RS02820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNL60_RS02820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNL60_RS02835	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FNL60_RS02860	COG1674	ftsk spoiiie
FNL60_RS02870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FNL60_RS02875	COG0081	regulation of translation
FNL60_RS02880	COG0528	UMP kinase activity
FNL60_RS02885	COG0233	cytoplasmic translational termination
FNL60_RS02895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FNL60_RS02900	COG4479	Belongs to the UPF0346 family
FNL60_RS02905	COG1702	phosphate starvation-inducible protein PhoH
FNL60_RS02910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FNL60_RS02915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FNL60_RS02920	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FNL60_RS02935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FNL60_RS02940	COG0237	dephospho-CoA kinase activity
FNL60_RS02945	COG2814	Major facilitator Superfamily
FNL60_RS02950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FNL60_RS02960	COG0557	exoribonuclease II activity
FNL60_RS02965	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FNL60_RS02970	COG0346	lactoylglutathione lyase activity
FNL60_RS02975	COG0778	Nitroreductase
FNL60_RS02985	COG2723	6-phospho-beta-galactosidase activity
FNL60_RS02990	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FNL60_RS02995	COG3711	transcriptional antiterminator
FNL60_RS02995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNL60_RS03000	COG1447	Phosphotransferase system cellobiose-specific component IIA
FNL60_RS03010	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FNL60_RS03030	COG1609	Transcriptional regulator
FNL60_RS03045	COG0438	transferase activity, transferring glycosyl groups
FNL60_RS03060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FNL60_RS03070	COG4716	Myosin-crossreactive antigen
FNL60_RS03075	COG1956	GAF domain-containing protein
FNL60_RS03080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FNL60_RS03135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FNL60_RS03140	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FNL60_RS03145	COG3842	ATPase activity
FNL60_RS03150	COG3833	ABC-type maltose transport systems, permease component
FNL60_RS03155	COG1175	transmembrane transport
FNL60_RS03165	COG1609	Transcriptional regulator
FNL60_RS03170	COG1640	4-alpha-glucanotransferase
FNL60_RS03175	COG0058	SHG alpha-glucan phosphorylase activity
FNL60_RS03180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FNL60_RS03185	COG0569	domain protein
FNL60_RS03205	COG4109	DRTGG domain
FNL60_RS03210	COG0024	Methionine aminopeptidase
FNL60_RS03215	COG1295	ribonuclease BN
FNL60_RS03235	COG1131	(ABC) transporter
FNL60_RS03245	COG4585	Histidine kinase
FNL60_RS03250	COG2197	response regulator
FNL60_RS03260	COG4708	membrane
FNL60_RS03265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FNL60_RS03270	COG1597	lipid kinase activity
FNL60_RS03275	COG1523	belongs to the glycosyl hydrolase 13 family
FNL60_RS03280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FNL60_RS03285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FNL60_RS03290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FNL60_RS03295	COG0297	glycogen (starch) synthase activity
FNL60_RS03300	COG0058	SHG alpha-glucan phosphorylase activity
FNL60_RS03310	COG0356	it plays a direct role in the translocation of protons across the membrane
FNL60_RS03315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FNL60_RS03320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FNL60_RS03325	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FNL60_RS03330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FNL60_RS03335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FNL60_RS03340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FNL60_RS03350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FNL60_RS03365	COG0765	amino acid transport
FNL60_RS03370	COG0765	amino acid transport
FNL60_RS03375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNL60_RS03380	COG1126	abc transporter atp-binding protein
FNL60_RS03385	COG0745	RESPONSE REGULATOR receiver
FNL60_RS03390	COG5002	protein histidine kinase activity
FNL60_RS03395	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FNL60_RS03400	COG0571	ribonuclease III activity
FNL60_RS03405	COG1196	nuclear chromosome segregation
FNL60_RS03410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FNL60_RS03420	COG0072	phenylalanine-tRNA ligase activity
FNL60_RS03420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNL60_RS03425	COG1396	sequence-specific DNA binding
FNL60_RS03445	COG0072	phenylalanine-tRNA ligase activity
FNL60_RS03445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FNL60_RS03460	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FNL60_RS03465	COG1074	ATP-dependent DNA helicase activity
FNL60_RS03470	COG1349	DNA-binding transcription factor activity
FNL60_RS03475	COG0698	ribose 5-phosphate isomerase
FNL60_RS03480	COG0698	ribose 5-phosphate isomerase
FNL60_RS03485	COG1105	Belongs to the carbohydrate kinase PfkB family
FNL60_RS03490	COG3684	Belongs to the aldolase LacD family
FNL60_RS03505	COG3775	system Galactitol-specific IIC component
FNL60_RS03510	COG1447	Phosphotransferase system cellobiose-specific component IIA
FNL60_RS03515	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FNL60_RS03515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
FNL60_RS03520	COG2723	6-phospho-beta-galactosidase activity
FNL60_RS03580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FNL60_RS03585	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FNL60_RS03595	COG1234	tRNA 3'-trailer cleavage
FNL60_RS03600	COG0300	oxidoreductase activity
FNL60_RS03605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FNL60_RS03605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FNL60_RS03610	COG2378	regulation of single-species biofilm formation
FNL60_RS03630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FNL60_RS03635	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FNL60_RS03645	COG2384	SAM-dependent methyltransferase
FNL60_RS03655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FNL60_RS03660	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FNL60_RS03675	COG1088	dTDP-glucose 4,6-dehydratase activity
FNL60_RS03685	COG1051	belongs to the nudix hydrolase family
FNL60_RS03690	COG0628	permease
FNL60_RS03700	COG0028	Belongs to the TPP enzyme family
FNL60_RS03705	COG3527	Alpha-acetolactate decarboxylase
FNL60_RS03710	COG1113	amino acid transport
FNL60_RS03715	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FNL60_RS03730	COG3842	ATPase activity
FNL60_RS03755	COG4808	Protein conserved in bacteria
FNL60_RS03765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FNL60_RS03780	COG1215	transferase activity, transferring glycosyl groups
FNL60_RS03790	COG0488	(ABC) transporter
FNL60_RS03795	COG3442	glutamine amidotransferase
FNL60_RS03800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FNL60_RS03805	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FNL60_RS03815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FNL60_RS03820	COG0542	response to heat
FNL60_RS03830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FNL60_RS03835	COG0022	dehydrogenase e1 component
FNL60_RS03840	COG0508	dehydrogenase complex catalyzes the overall conversion of
FNL60_RS03845	COG2249	NAD(P)H dehydrogenase (quinone) activity
FNL60_RS03855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FNL60_RS03865	COG1051	belongs to the nudix hydrolase family
FNL60_RS03870	COG0647	UMP catabolic process
FNL60_RS03880	COG0577	efflux transmembrane transporter activity
FNL60_RS03880	COG1136	(ABC) transporter
FNL60_RS03890	COG3976	FMN-binding domain protein
FNL60_RS03890	COG1053	succinate dehydrogenase
FNL60_RS03905	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
FNL60_RS03910	COG1518	maintenance of DNA repeat elements
FNL60_RS03915	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FNL60_RS03940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FNL60_RS03965	COG0481	GTPase activity
FNL60_RS03990	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FNL60_RS04000	COG0673	inositol 2-dehydrogenase activity
FNL60_RS04005	COG0572	uridine kinase
FNL60_RS04015	COG0473	3-isopropylmalate dehydrogenase activity
FNL60_RS04020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FNL60_RS04025	COG0066	3-isopropylmalate dehydratase activity
FNL60_RS04040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
FNL60_RS04040	COG0456	acetyltransferase
FNL60_RS04060	COG2801	Transposase and inactivated derivatives
FNL60_RS04075	COG2226	methyltransferase
FNL60_RS04080	COG1136	(ABC) transporter
FNL60_RS04100	COG1309	transcriptional regulator
FNL60_RS04135	COG1136	(ABC) transporter
FNL60_RS04225	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FNL60_RS04235	COG2884	Cell division ATP-binding protein ftsE
FNL60_RS04240	COG2177	Part of the ABC transporter FtsEX involved in
FNL60_RS04285	COG1122	ATPase activity
FNL60_RS04295	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FNL60_RS04295	COG1199	ATP-dependent helicase activity
FNL60_RS04300	COG0436	Aminotransferase
FNL60_RS04305	COG0017	Asparaginyl-tRNA synthetase
FNL60_RS04315	COG0371	Dehydrogenase
FNL60_RS04320	COG0251	oxidation-reduction process
FNL60_RS04330	COG1660	Displays ATPase and GTPase activities
FNL60_RS04340	COG1481	regulation of sporulation
FNL60_RS04355	COG2226	methyltransferase
FNL60_RS04370	COG0254	rRNA binding
FNL60_RS04375	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FNL60_RS04380	COG0625	glutathione transferase activity
FNL60_RS04385	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FNL60_RS04390	COG0716	FMN binding
FNL60_RS04405	COG1605	Chorismate mutase
FNL60_RS04405	COG0077	Prephenate dehydratase
FNL60_RS04410	COG0038	chloride channel
FNL60_RS04415	COG0038	chloride channel
FNL60_RS04420	COG0335	large ribosomal subunit rRNA binding
FNL60_RS04430	COG2814	Major facilitator Superfamily
FNL60_RS04455	COG0772	Belongs to the SEDS family
FNL60_RS04470	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FNL60_RS04480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FNL60_RS04485	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FNL60_RS04490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FNL60_RS04495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FNL60_RS04500	COG0560	Phosphoserine phosphatase
FNL60_RS04505	COG0131	Imidazoleglycerol-phosphate dehydratase
FNL60_RS04515	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FNL60_RS04520	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FNL60_RS04525	COG0107	imidazoleglycerol-phosphate synthase activity
FNL60_RS04530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FNL60_RS04600	COG0148	phosphopyruvate hydratase activity
FNL60_RS04610	COG1011	Hydrolase
FNL60_RS04620	COG0322	excinuclease ABC activity
FNL60_RS04630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FNL60_RS04635	COG1573	uracil-dna glycosylase
FNL60_RS04655	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FNL60_RS04660	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FNL60_RS04665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FNL60_RS04695	COG0813	purine-nucleoside phosphorylase activity
FNL60_RS04710	COG0543	2 iron, 2 sulfur cluster binding
FNL60_RS04715	COG0167	dihydroorotate dehydrogenase activity
FNL60_RS04720	COG0284	orotidine-5'-phosphate decarboxylase activity
FNL60_RS04725	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FNL60_RS04735	COG1881	PFAM PEBP family protein
FNL60_RS04740	COG2315	Protein conserved in bacteria
FNL60_RS04750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNL60_RS04755	COG0765	amino acid transport
FNL60_RS04760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FNL60_RS04770	COG0737	Belongs to the 5'-nucleotidase family
FNL60_RS04775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FNL60_RS04780	COG0187	DNA topoisomerase II activity
FNL60_RS04795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FNL60_RS04815	COG0539	negative regulation of cytoplasmic translation
FNL60_RS04845	COG1131	(ABC) transporter
FNL60_RS04850	COG1725	Transcriptional regulator
FNL60_RS04860	COG0205	6-phosphofructokinase activity
FNL60_RS04865	COG0469	pyruvate kinase activity
FNL60_RS04870	COG2261	transglycosylase associated protein
FNL60_RS04880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FNL60_RS04885	COG2213	PTS system mannitol-specific
FNL60_RS04890	COG3711	transcriptional antiterminator
FNL60_RS04895	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNL60_RS04900	COG0246	Mannitol dehydrogenase
FNL60_RS04905	COG2824	Alkylphosphonate utilization operon protein PhnA
FNL60_RS04910	COG0765	amino acid transport
FNL60_RS04915	COG1126	abc transporter atp-binding protein
FNL60_RS04920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNL60_RS04925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FNL60_RS04930	COG1115	amino acid carrier protein
FNL60_RS04935	COG0210	DNA helicase
FNL60_RS04940	COG2873	o-acetylhomoserine
FNL60_RS04955	COG0785	Cytochrome C biogenesis protein
FNL60_RS04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FNL60_RS04985	COG2375	cellular response to nickel ion
FNL60_RS04985	COG1132	(ABC) transporter
FNL60_RS04990	COG1132	(ABC) transporter
FNL60_RS05060	COG0745	RESPONSE REGULATOR receiver
FNL60_RS05065	COG2205	protein histidine kinase activity
FNL60_RS05070	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FNL60_RS05075	COG0196	riboflavin kinase activity
FNL60_RS05080	COG1393	Belongs to the ArsC family
FNL60_RS05085	COG4476	Belongs to the UPF0223 family
FNL60_RS05090	COG0483	inositol monophosphate 1-phosphatase activity
FNL60_RS05095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FNL60_RS05095	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
FNL60_RS05105	COG0573	inorganic phosphate transmembrane transporter activity
FNL60_RS05110	COG0581	inorganic phosphate transmembrane transporter activity
FNL60_RS05115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FNL60_RS05120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FNL60_RS05125	COG0704	Plays a role in the regulation of phosphate uptake
FNL60_RS05140	COG0745	RESPONSE REGULATOR receiver
FNL60_RS05145	COG5002	protein histidine kinase activity
FNL60_RS05150	COG0268	Binds directly to 16S ribosomal RNA
FNL60_RS05155	COG1072	(Pantothenic acid kinase))
FNL60_RS05160	COG2813	Specifically methylates the guanine in position
FNL60_RS05165	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FNL60_RS05170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FNL60_RS05175	COG0295	cytidine deaminase activity
FNL60_RS05180	COG1744	ABC transporter substrate-binding protein PnrA-like
FNL60_RS05185	COG3845	ABC transporter
FNL60_RS05190	COG4603	Belongs to the binding-protein-dependent transport system permease family
FNL60_RS05195	COG1079	Belongs to the binding-protein-dependent transport system permease family
FNL60_RS05210	COG0039	L-malate dehydrogenase activity
FNL60_RS05220	COG3764	Sortase (surface protein transpeptidase)
FNL60_RS05225	COG0346	lactoylglutathione lyase activity
FNL60_RS05240	COG0561	phosphatase activity
FNL60_RS05250	COG0346	lactoylglutathione lyase activity
FNL60_RS05260	COG0406	alpha-ribazole phosphatase activity
FNL60_RS05270	COG2723	6-phospho-beta-galactosidase activity
FNL60_RS05275	COG0628	permease
FNL60_RS05280	COG1063	alcohol dehydrogenase
FNL60_RS05295	COG1174	glycine betaine transport
FNL60_RS05300	COG1136	(ABC) transporter
FNL60_RS05305	COG0577	efflux transmembrane transporter activity
FNL60_RS05315	COG3976	FMN-binding domain protein
FNL60_RS05315	COG0431	NADPH-dependent FMN reductase
FNL60_RS05315	COG1053	succinate dehydrogenase
FNL60_RS05330	COG1942	4-Oxalocrotonate Tautomerase
FNL60_RS05335	COG1435	thymidine kinase activity
FNL60_RS05340	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FNL60_RS05345	COG2890	protein-(glutamine-N5) methyltransferase activity
FNL60_RS05350	COG0009	L-threonylcarbamoyladenylate synthase
FNL60_RS05355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FNL60_RS05370	COG1132	(ABC) transporter
FNL60_RS05375	COG1132	(ABC) transporter
FNL60_RS05380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FNL60_RS05385	COG4684	Psort location CytoplasmicMembrane, score
FNL60_RS05390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FNL60_RS05400	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FNL60_RS05405	COG1247	-acetyltransferase
FNL60_RS05425	COG1131	(ABC) transporter
FNL60_RS05435	COG0519	Catalyzes the synthesis of GMP from XMP
FNL60_RS05440	COG2188	Transcriptional regulator
FNL60_RS05450	COG3448	diguanylate cyclase activity
FNL60_RS05450	COG4175	Glycine betaine
FNL60_RS05460	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FNL60_RS05465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FNL60_RS05495	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FNL60_RS05500	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FNL60_RS05510	COG1104	cysteine desulfurase activity
FNL60_RS05515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FNL60_RS05520	COG4116	CYTH
FNL60_RS05535	COG2357	RelA SpoT domain protein
FNL60_RS05540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FNL60_RS05545	COG0564	pseudouridine synthase activity
FNL60_RS05550	COG0280	phosphate acetyltransferase
FNL60_RS05560	COG1131	(ABC) transporter
FNL60_RS05565	COG4221	oxidoreductase activity
FNL60_RS05570	COG1442	glycosyl transferase family 8
FNL60_RS05575	COG0745	RESPONSE REGULATOR receiver
FNL60_RS05580	COG5002	protein histidine kinase activity
FNL60_RS05590	COG1131	(ABC) transporter
FNL60_RS05595	COG4974	Belongs to the 'phage' integrase family
FNL60_RS05625	COG3052	prosthetic group binding
FNL60_RS05630	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FNL60_RS05635	COG0511	ligase activity, forming carbon-carbon bonds
FNL60_RS05645	COG2851	Citrate transporter
FNL60_RS05655	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
FNL60_RS05660	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
FNL60_RS05665	COG0642	Histidine kinase
FNL60_RS05670	COG0745	RESPONSE REGULATOR receiver
FNL60_RS05680	COG1136	(ABC) transporter
FNL60_RS05685	COG0366	Alpha amylase catalytic
FNL60_RS05685	COG5263	repeat protein
FNL60_RS05695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FNL60_RS05700	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FNL60_RS05705	COG0758	DNA mediated transformation
FNL60_RS05720	COG4607	ABC-type enterochelin transport system periplasmic component
FNL60_RS05725	COG4604	ABC transporter, ATP-binding protein
FNL60_RS05730	COG4605	iron ion homeostasis
FNL60_RS05735	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FNL60_RS05740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FNL60_RS05745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FNL60_RS05760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FNL60_RS05765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FNL60_RS05775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FNL60_RS05780	COG4932	domain protein
FNL60_RS05810	COG1263	PTS System
FNL60_RS05810	COG2190	(PTS) system
FNL60_RS05810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FNL60_RS05815	COG3711	transcriptional antiterminator
FNL60_RS05820	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FNL60_RS05825	COG1177	transmembrane transport
FNL60_RS05830	COG1176	ABC-type spermidine putrescine transport system, permease component I
FNL60_RS05835	COG3842	ATPase activity
FNL60_RS05840	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FNL60_RS05860	COG0302	gtp cyclohydrolase
FNL60_RS05865	COG0285	dihydrofolate synthase activity
FNL60_RS05870	COG0083	homoserine kinase activity
FNL60_RS05880	COG0726	polysaccharide deacetylase
FNL60_RS05885	COG1960	acyl-CoA dehydrogenase activity
FNL60_RS05895	COG0222	ribosome binding
FNL60_RS05900	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FNL60_RS05925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNL60_RS05930	COG2040	homocysteine
FNL60_RS05940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FNL60_RS05945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FNL60_RS05955	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FNL60_RS05960	COG3201	nicotinamide mononucleotide transporter
FNL60_RS05965	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FNL60_RS05970	COG3425	synthase
FNL60_RS05985	COG1272	protein, Hemolysin III
FNL60_RS05990	COG1304	FMN binding
FNL60_RS06005	COG1126	abc transporter atp-binding protein
FNL60_RS06010	COG0765	amino acid transport
FNL60_RS06015	COG0765	amino acid transport
FNL60_RS06020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNL60_RS06030	COG0583	DNA-binding transcription factor activity
FNL60_RS06035	COG3759	membrane
FNL60_RS06045	COG0745	RESPONSE REGULATOR receiver
FNL60_RS06050	COG2357	RelA SpoT domain protein
FNL60_RS06060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FNL60_RS06065	COG1132	(ABC) transporter
FNL60_RS06080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FNL60_RS06090	COG0602	queuosine metabolic process
FNL60_RS06095	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FNL60_RS06105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FNL60_RS06115	COG0366	Alpha amylase catalytic
FNL60_RS06115	COG5263	repeat protein
FNL60_RS06125	COG1132	(ABC) transporter
FNL60_RS06135	COG0488	(ABC) transporter
FNL60_RS06140	COG0617	tRNA 3'-terminal CCA addition
FNL60_RS06145	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FNL60_RS06150	COG1307	EDD domain protein, DegV family
FNL60_RS06165	COG1131	(ABC) transporter
FNL60_RS06185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FNL60_RS06190	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
FNL60_RS06195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FNL60_RS06200	COG1609	Transcriptional regulator
FNL60_RS06205	COG0366	Alpha amylase catalytic
FNL60_RS06210	COG3842	ATPase activity
FNL60_RS06215	COG0366	Alpha amylase catalytic
FNL60_RS06220	COG0395	ABC-type sugar transport system, permease component
FNL60_RS06225	COG1175	transmembrane transport
FNL60_RS06230	COG1653	transport
FNL60_RS06235	COG3345	alpha-galactosidase
FNL60_RS06240	COG2207	Transcriptional regulator
FNL60_RS06255	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FNL60_RS06255	COG0646	methionine synthase
FNL60_RS06260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FNL60_RS06265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNL60_RS06265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FNL60_RS06265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNL60_RS06270	COG1105	Belongs to the carbohydrate kinase PfkB family
FNL60_RS06275	COG1349	DNA-binding transcription factor activity
FNL60_RS06280	COG0492	ferredoxin-NADP+ reductase activity
FNL60_RS06285	COG0336	Belongs to the RNA methyltransferase TrmD family
FNL60_RS06290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FNL60_RS06295	COG1837	Belongs to the UPF0109 family
FNL60_RS06300	COG0228	four-way junction DNA binding
FNL60_RS06305	COG0577	efflux transmembrane transporter activity
FNL60_RS06310	COG1136	(ABC) transporter
FNL60_RS06320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FNL60_RS06325	COG0505	Belongs to the CarA family
FNL60_RS06330	COG0540	Belongs to the ATCase OTCase family
FNL60_RS06340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FNL60_RS06350	COG0564	pseudouridine synthase activity
FNL60_RS06355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FNL60_RS06360	COG0583	DNA-binding transcription factor activity
FNL60_RS06365	COG2816	NAD+ diphosphatase activity
FNL60_RS06375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FNL60_RS06385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FNL60_RS06405	COG0301	tRNA thio-modification
FNL60_RS06410	COG1104	cysteine desulfurase activity
FNL60_RS06420	COG0285	dihydrofolate synthase activity
FNL60_RS06425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FNL60_RS06430	COG0656	L-ascorbic acid biosynthetic process
FNL60_RS06435	COG3942	CHAP domain
FNL60_RS06450	COG0463	Glycosyl transferase, family 2
FNL60_RS06460	COG1368	sulfuric ester hydrolase activity
FNL60_RS06495	COG1091	dTDP-4-dehydrorhamnose reductase activity
FNL60_RS06500	COG2151	metal-sulfur cluster biosynthetic enzyme
FNL60_RS06505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FNL60_RS06510	COG0358	DNA primase activity
FNL60_RS06520	COG1970	mechanosensitive ion channel activity
FNL60_RS06530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNL60_RS06540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FNL60_RS06545	COG1051	belongs to the nudix hydrolase family
FNL60_RS06565	COG0556	nucleotide-excision repair
FNL60_RS06580	COG1126	abc transporter atp-binding protein
FNL60_RS06585	COG0488	(ABC) transporter
FNL60_RS06595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FNL60_RS06660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FNL60_RS06670	COG0077	Prephenate dehydratase
FNL60_RS06675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FNL60_RS06680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FNL60_RS06685	COG3679	Belongs to the UPF0342 family
FNL60_RS06690	COG0287	Prephenate dehydrogenase
FNL60_RS06695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FNL60_RS06700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FNL60_RS06705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FNL60_RS06710	COG0710	3-dehydroquinate dehydratase activity
FNL60_RS06715	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FNL60_RS06720	COG1368	sulfuric ester hydrolase activity
FNL60_RS06740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FNL60_RS06745	COG5263	repeat protein
FNL60_RS06745	COG0366	Alpha amylase catalytic
FNL60_RS06755	COG1914	H( )-stimulated, divalent metal cation uptake system
FNL60_RS06760	COG4443	Transcriptional Coactivator p15 (PC4)
FNL60_RS06775	COG0450	alkyl hydroperoxide reductase
FNL60_RS06780	COG0826	peptidase U32
FNL60_RS06805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FNL60_RS06810	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FNL60_RS06820	COG3091	SprT-like family
FNL60_RS06825	COG2183	response to ionizing radiation
FNL60_RS06840	COG0701	Predicted permease
FNL60_RS06845	COG3689	TIGRFAM TIGR03943 family protein
FNL60_RS06850	COG0477	Major facilitator Superfamily
FNL60_RS06855	COG0552	protein localization to endoplasmic reticulum
FNL60_RS06860	COG0561	phosphatase activity
FNL60_RS06865	COG0561	phosphatase activity
FNL60_RS06915	COG1131	(ABC) transporter
FNL60_RS06925	COG0604	alcohol dehydrogenase
FNL60_RS06940	COG0584	glycerophosphoryl diester phosphodiesterase
FNL60_RS06965	COG1078	dGTPase activity
FNL60_RS06975	COG2348	transferase activity, transferring amino-acyl groups
FNL60_RS06985	COG0149	triose-phosphate isomerase activity
FNL60_RS06990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FNL60_RS06995	COG0772	Belongs to the SEDS family
FNL60_RS07005	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FNL60_RS07025	COG3859	Proton-coupled thiamine transporter YuaJ
FNL60_RS07040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FNL60_RS07050	COG0588	phosphoglycerate mutase activity
FNL60_RS07055	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FNL60_RS07060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FNL60_RS07065	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FNL60_RS07070	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FNL60_RS07090	COG2195	Cleaves the N-terminal amino acid of tripeptides
FNL60_RS07145	COG0656	L-ascorbic acid biosynthetic process
FNL60_RS07150	COG0656	L-ascorbic acid biosynthetic process
FNL60_RS07155	COG0789	Transcriptional regulator
FNL60_RS07160	COG1012	belongs to the aldehyde dehydrogenase family
FNL60_RS07165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FNL60_RS07170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNL60_RS07180	COG0538	isocitrate dehydrogenase activity
FNL60_RS07190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FNL60_RS07195	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FNL60_RS07200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FNL60_RS07210	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FNL60_RS07215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FNL60_RS07220	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FNL60_RS07225	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FNL60_RS07265	COG1131	(ABC) transporter
FNL60_RS07285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FNL60_RS07295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FNL60_RS07300	COG4122	O-methyltransferase activity
FNL60_RS07305	COG0131	Imidazoleglycerol-phosphate dehydratase
FNL60_RS07305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FNL60_RS07340	COG0604	alcohol dehydrogenase
FNL60_RS07340	COG1028	Short-chain dehydrogenase reductase Sdr
FNL60_RS07340	COG3321	synthase
FNL60_RS07345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FNL60_RS07355	COG1187	pseudouridine synthase activity
FNL60_RS07365	COG0363	glucosamine-6-phosphate deaminase activity
FNL60_RS07375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FNL60_RS07400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FNL60_RS07415	COG2333	competence protein COMEC
FNL60_RS07415	COG0658	competence protein
FNL60_RS07420	COG1596	polysaccharide export
FNL60_RS07420	COG1555	photosystem II stabilization
FNL60_RS07425	COG0204	Acyl-transferase
FNL60_RS07430	COG0726	polysaccharide deacetylase
FNL60_RS07440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FNL60_RS07480	COG0513	Belongs to the DEAD box helicase family
FNL60_RS07485	COG3064	Membrane
FNL60_RS07485	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FNL60_RS07495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FNL60_RS07515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FNL60_RS07520	COG0385	Bile acid
FNL60_RS07530	COG1181	Belongs to the D-alanine--D-alanine ligase family
FNL60_RS07535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FNL60_RS07540	COG0768	penicillin binding
FNL60_RS07545	COG0588	phosphoglycerate mutase activity
FNL60_RS07560	COG0735	belongs to the Fur family
FNL60_RS07575	COG2801	Transposase and inactivated derivatives
FNL60_RS07580	COG0776	regulation of translation
FNL60_RS07590	COG2755	lipolytic protein G-D-S-L family
FNL60_RS07595	COG1307	EDD domain protein, DegV family
FNL60_RS07600	COG0497	DNA recombination
FNL60_RS07605	COG1438	arginine binding
FNL60_RS07610	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FNL60_RS07620	COG1722	exodeoxyribonuclease VII activity
FNL60_RS07625	COG1570	exodeoxyribonuclease VII activity
FNL60_RS07630	COG3275	phosphorelay sensor kinase activity
FNL60_RS07635	COG3279	Response regulator of the LytR AlgR family
FNL60_RS07640	COG1380	Effector of murein hydrolase LrgA
FNL60_RS07645	COG1346	cytolysis
FNL60_RS07650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FNL60_RS07655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FNL60_RS07675	COG1126	abc transporter atp-binding protein
FNL60_RS07680	COG0765	amino acid transport
FNL60_RS07685	COG4703	Protein of unknown function (DUF1797)
FNL60_RS07690	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FNL60_RS07695	COG0542	response to heat
FNL60_RS07710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FNL60_RS07715	COG3599	regulation of cell shape
FNL60_RS07720	COG2302	S4 RNA-binding domain
FNL60_RS07730	COG1799	cell septum assembly
FNL60_RS07735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FNL60_RS07745	COG0849	cell division
FNL60_RS07755	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FNL60_RS07760	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FNL60_RS07770	COG1217	gtp-binding protein TYPA
FNL60_RS07780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FNL60_RS07785	COG1940	carbohydrate kinase activity
FNL60_RS07795	COG0783	Belongs to the Dps family
FNL60_RS07805	COG0159	tryptophan synthase activity
FNL60_RS07810	COG0133	tryptophan synthase activity
FNL60_RS07815	COG0135	phosphoribosylanthranilate isomerase activity
FNL60_RS07820	COG0134	indole-3-glycerol-phosphate synthase activity
FNL60_RS07825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FNL60_RS07830	COG0512	Glutamine amidotransferase of anthranilate synthase
FNL60_RS07835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FNL60_RS07855	COG3804	dihydrodipicolinate reductase
FNL60_RS07865	COG1132	(ABC) transporter
FNL60_RS07870	COG1132	(ABC) transporter
FNL60_RS07880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FNL60_RS07885	COG4470	Protein conserved in bacteria
FNL60_RS07890	COG0737	Belongs to the 5'-nucleotidase family
FNL60_RS07895	COG3480	Lon protease (S16) C-terminal proteolytic domain
FNL60_RS07900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FNL60_RS07905	COG0742	ribosomal rna small subunit methyltransferase
FNL60_RS07910	COG4716	Myosin-crossreactive antigen
FNL60_RS07930	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FNL60_RS07965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNL60_RS07975	COG0561	phosphatase activity
FNL60_RS07980	COG1349	DNA-binding transcription factor activity
FNL60_RS08025	COG1040	competence protein
FNL60_RS08030	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FNL60_RS08035	COG1739	Uncharacterized protein family UPF0029
FNL60_RS08055	COG1882	Formate acetyltransferase
FNL60_RS08060	COG1349	DNA-binding transcription factor activity
FNL60_RS08065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FNL60_RS08070	COG1098	S1 RNA binding domain
FNL60_RS08080	COG2197	response regulator
FNL60_RS08085	COG4585	Histidine kinase
FNL60_RS08105	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FNL60_RS08105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FNL60_RS08110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FNL60_RS08115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FNL60_RS08120	COG1758	RNA polymerase activity
FNL60_RS08125	COG0194	GDP metabolic process
FNL60_RS08130	COG4372	Transposase
FNL60_RS08130	COG1418	mRNA catabolic process
FNL60_RS08135	COG1854	S-ribosylhomocysteine lyase activity
FNL60_RS08145	COG0116	Belongs to the methyltransferase superfamily
FNL60_RS08155	COG3599	regulation of cell shape
FNL60_RS08160	COG4474	Belongs to the UPF0398 family
FNL60_RS08165	COG3331	DNA recombination
FNL60_RS08170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FNL60_RS08175	COG3579	cysteine-type endopeptidase activity
FNL60_RS08185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FNL60_RS08190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FNL60_RS08195	COG0492	ferredoxin-NADP+ reductase activity
FNL60_RS08205	COG1126	abc transporter atp-binding protein
FNL60_RS08220	COG0513	Belongs to the DEAD box helicase family
FNL60_RS08230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FNL60_RS08235	COG0768	penicillin binding
FNL60_RS08240	COG4839	cell division protein FtsL
FNL60_RS08245	COG0275	rRNA processing
FNL60_RS08255	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FNL60_RS08260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FNL60_RS08270	COG4224	UPF0291 protein
FNL60_RS08275	COG0751	glycine-tRNA ligase activity
FNL60_RS08280	COG0752	glycyl-tRNA synthetase alpha subunit
FNL60_RS08290	COG1673	EVE domain
FNL60_RS08310	COG1924	4 iron, 4 sulfur cluster binding
FNL60_RS08340	COG1131	(ABC) transporter
FNL60_RS08350	COG0561	phosphatase activity
FNL60_RS08360	COG2217	Heavy metal translocating P-type atpase
FNL60_RS08375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FNL60_RS08380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FNL60_RS08390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FNL60_RS08395	COG0195	Participates in both transcription termination and antitermination
FNL60_RS08400	COG0779	Required for maturation of 30S ribosomal subunits
FNL60_RS08410	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FNL60_RS08420	COG4473	ABC transporter
FNL60_RS08425	COG1131	(ABC) transporter
FNL60_RS08430	COG0537	adenosine 5'-monophosphoramidase activity
FNL60_RS08440	COG1316	TRANSCRIPTIONal
FNL60_RS08445	COG0802	atpase or kinase
FNL60_RS08450	COG2252	PERMEase
FNL60_RS08460	COG0561	phosphatase activity
FNL60_RS08475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FNL60_RS08480	COG1882	Formate acetyltransferase
FNL60_RS08490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FNL60_RS08505	COG2936	dipeptidyl-peptidase activity
FNL60_RS08510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FNL60_RS08515	COG1733	regulation of RNA biosynthetic process
FNL60_RS08520	COG0778	Nitroreductase
FNL60_RS08530	COG2081	HI0933 family
FNL60_RS08550	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FNL60_RS08555	COG0456	acetyltransferase
FNL60_RS08560	COG1214	PFAM Peptidase M22, glycoprotease
FNL60_RS08570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FNL60_RS08575	COG0667	Aldo Keto reductase
FNL60_RS08595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FNL60_RS08610	COG2226	methyltransferase
FNL60_RS08630	COG5503	Protein of unknown function (DUF1447)
FNL60_RS08640	COG3942	CHAP domain
FNL60_RS08645	COG0493	'glutamate synthase
FNL60_RS08650	COG0067	glutamate synthase
FNL60_RS08650	COG0070	glutamate synthase
FNL60_RS08650	COG0069	glutamate synthase activity
FNL60_RS08655	COG0174	glutamine synthetase
FNL60_RS08660	COG0789	Transcriptional regulator
FNL60_RS08670	COG0126	phosphoglycerate kinase activity
FNL60_RS08680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FNL60_RS08685	COG0049	tRNA binding
FNL60_RS08690	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FNL60_RS08700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FNL60_RS08725	COG1162	GTPase activity
FNL60_RS08745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FNL60_RS08780	COG0084	hydrolase, TatD family'
FNL60_RS08785	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FNL60_RS08800	COG0706	membrane insertase activity
FNL60_RS08805	COG0594	ribonuclease P activity
FNL60_RS08810	COG0165	Argininosuccinate lyase
FNL60_RS08815	COG0137	argininosuccinate synthase activity
FNL60_RS08830	COG1827	regulation of RNA biosynthetic process
FNL60_RS08835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FNL60_RS08860	COG0756	dUTP diphosphatase activity
FNL60_RS08865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FNL60_RS08870	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FNL60_RS08875	COG0457	Tetratricopeptide repeat
FNL60_RS08875	COG0705	Rhomboid family
FNL60_RS08880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FNL60_RS08885	COG1473	amidohydrolase
FNL60_RS08890	COG2171	N-acyltransferase activity
FNL60_RS08905	COG3732	PTS system glucitol sorbitol-specific
FNL60_RS08910	COG3730	PTS system glucitol sorbitol-specific
FNL60_RS08920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNL60_RS08920	COG3711	transcriptional antiterminator
FNL60_RS08930	COG0166	Belongs to the GPI family
FNL60_RS08960	COG1234	tRNA 3'-trailer cleavage
FNL60_RS08975	COG0343	queuine tRNA-ribosyltransferase activity
FNL60_RS08985	COG1832	CoA-binding protein
FNL60_RS08990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNL60_RS08990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FNL60_RS09020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FNL60_RS09040	COG2274	protein secretion by the type I secretion system
FNL60_RS09100	COG3623	hexulose-6-phosphate isomerase
FNL60_RS09110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FNL60_RS09125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FNL60_RS09130	COG2918	glutathione biosynthetic process
FNL60_RS09130	COG1181	Belongs to the D-alanine--D-alanine ligase family
FNL60_RS09140	COG2957	Belongs to the agmatine deiminase family
FNL60_RS09145	COG0531	amino acid
FNL60_RS09150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FNL60_RS09165	COG4608	Belongs to the ABC transporter superfamily
FNL60_RS09170	COG0444	Belongs to the ABC transporter superfamily
FNL60_RS09175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FNL60_RS09180	COG0601	transmembrane transport
FNL60_RS09185	COG4166	transmembrane transport
FNL60_RS09200	COG0719	Fe-S assembly protein
FNL60_RS09210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FNL60_RS09215	COG0719	Fe-S assembly protein
FNL60_RS09225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FNL60_RS09230	COG4862	establishment of competence for transformation
FNL60_RS09235	COG1968	undecaprenyl-diphosphatase activity
FNL60_RS09245	COG0765	amino acid transport
FNL60_RS09250	COG1126	abc transporter atp-binding protein
FNL60_RS09260	COG1131	(ABC) transporter
FNL60_RS09270	COG1309	transcriptional regulator
FNL60_RS09280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FNL60_RS09285	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FNL60_RS09290	COG0440	acetolactate synthase activity
FNL60_RS09295	COG0028	Belongs to the TPP enzyme family
FNL60_RS09300	COG1461	Dihydroxyacetone kinase
FNL60_RS09340	COG0582	viral genome integration into host DNA
FNL60_RS09435	COG0203	ribosomal protein L17
FNL60_RS09440	COG0202	RNA polymerase activity
FNL60_RS09445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FNL60_RS09450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FNL60_RS09460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FNL60_RS09465	COG0563	adenylate kinase activity
FNL60_RS09470	COG0201	protein transport
FNL60_RS09475	COG0200	Binds to the 23S rRNA
FNL60_RS09480	COG1841	ribosomal large subunit assembly
FNL60_RS09485	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FNL60_RS09495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FNL60_RS09500	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FNL60_RS09505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FNL60_RS09510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FNL60_RS09515	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FNL60_RS09520	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FNL60_RS09525	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FNL60_RS09530	COG0255	Belongs to the universal ribosomal protein uL29 family
FNL60_RS09535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FNL60_RS09540	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FNL60_RS09545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FNL60_RS09555	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FNL60_RS09560	COG0089	rRNA binding
FNL60_RS09570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FNL60_RS09575	COG0051	transcription antitermination factor activity, RNA binding
FNL60_RS09585	COG1621	beta-fructofuranosidase activity
FNL60_RS09590	COG0542	response to heat
FNL60_RS09595	COG4463	regulation of RNA biosynthetic process
FNL60_RS09600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FNL60_RS09605	COG0052	Belongs to the universal ribosomal protein uS2 family
FNL60_RS09620	COG1619	proteins homologs of microcin C7 resistance protein MccF
FNL60_RS09625	COG3590	peptidase
FNL60_RS09635	COG0366	Alpha amylase catalytic
FNL60_RS09640	COG1263	PTS System
FNL60_RS09640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FNL60_RS09645	COG2188	Transcriptional regulator
FNL60_RS09650	COG5297	Belongs to the glycosyl hydrolase family 6
FNL60_RS09655	COG1490	D-aminoacyl-tRNA deacylase activity
FNL60_RS09670	COG2190	(PTS) system
FNL60_RS09670	COG1263	PTS System
FNL60_RS09670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FNL60_RS09685	COG1609	Transcriptional regulator
FNL60_RS09690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FNL60_RS09695	COG2264	protein methyltransferase activity
FNL60_RS09715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FNL60_RS09730	COG2217	Heavy metal translocating P-type atpase
FNL60_RS09750	COG0577	efflux transmembrane transporter activity
FNL60_RS09750	COG1136	(ABC) transporter
FNL60_RS09760	COG1396	sequence-specific DNA binding
FNL60_RS09775	COG1250	3-hydroxyacyl-CoA dehydrogenase
FNL60_RS09780	COG0577	efflux transmembrane transporter activity
FNL60_RS09780	COG1136	(ABC) transporter
FNL60_RS09795	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
FNL60_RS09820	COG2855	membrane
FNL60_RS09825	COG0583	DNA-binding transcription factor activity
FNL60_RS09835	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FNL60_RS09845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FNL60_RS09855	COG0463	Glycosyl transferase, family 2
FNL60_RS09860	COG0428	transporter
FNL60_RS09865	COG3022	response to hydroperoxide
FNL60_RS09900	COG3906	Belongs to the UPF0473 family
FNL60_RS09905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FNL60_RS09910	COG4472	Bacterial protein of unknown function (DUF965)
FNL60_RS09935	COG1393	Belongs to the ArsC family
FNL60_RS09940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FNL60_RS09945	COG1058	Belongs to the CinA family
FNL60_RS09945	COG1546	Belongs to the CinA family
FNL60_RS09950	COG0519	Catalyzes the synthesis of GMP from XMP
FNL60_RS09955	COG0632	four-way junction helicase activity
FNL60_RS09960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FNL60_RS09970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FNL60_RS09980	COG1438	arginine binding
FNL60_RS10000	COG0018	arginyl-trna synthetase
FNL60_RS10005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FNL60_RS10010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FNL60_RS10015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FNL60_RS10020	COG0124	histidyl-tRNA synthetase
FNL60_RS10025	COG0531	amino acid
FNL60_RS10030	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FNL60_RS10035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FNL60_RS10060	COG2814	Major facilitator Superfamily
FNL60_RS10080	COG0789	Transcriptional regulator
FNL60_RS10085	COG1028	Short-chain dehydrogenase reductase Sdr
FNL60_RS10110	COG2094	Belongs to the DNA glycosylase MPG family
FNL60_RS10125	COG1733	regulation of RNA biosynthetic process
FNL60_RS10135	COG1012	belongs to the aldehyde dehydrogenase family
FNL60_RS10140	COG0129	dihydroxy-acid dehydratase activity
FNL60_RS10145	COG2151	metal-sulfur cluster biosynthetic enzyme
FNL60_RS10170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FNL60_RS10185	COG0305	Participates in initiation and elongation during chromosome replication
FNL60_RS10190	COG0359	binds to the 23S rRNA
FNL60_RS10200	COG0445	tRNA wobble uridine modification
FNL60_RS10210	COG0482	sulfurtransferase activity
FNL60_RS10215	COG0741	lytic transglycosylase activity
FNL60_RS10225	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FNL60_RS10230	COG1122	ATPase activity
FNL60_RS10235	COG1122	ATPase activity
FNL60_RS10240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FNL60_RS10250	COG0612	Peptidase, M16
FNL60_RS10265	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FNL60_RS10270	COG0516	GMP reductase activity
FNL60_RS10270	COG0517	IMP dehydrogenase activity
FNL60_RS10275	COG0180	Tryptophanyl-tRNA synthetase
FNL60_RS10280	COG0488	(ABC) transporter
FNL60_RS10310	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FNL60_RS10315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FNL60_RS10320	COG1475	DNA binding